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2201, 2206, 2317, 2423, 2475, 2560, 2599, 2641, 2673, 2720, 2806, 2912, 2941, 3142], 'angioplasty': [110, 223, 2202, 2360, 2596, 2674, 2721, 2978, 2990], '(PTCA)': [111], 'in': [112, 168, 290, 319, 358, 374, 385, 388, 406, 482, 490, 595, 605, 670, 724, 778, 782, 794, 803, 805, 815, 846, 856, 919, 988, 1013, 1017, 1058, 1132, 1236, 1260, 1330, 1383, 1433, 1441, 1473, 1499, 1533, 1558, 1626, 1641, 1707, 1715, 1751, 1806, 1961, 1968, 1995, 2031, 2076, 2204, 2218, 2258, 2361, 2397, 2467, 2597, 2638, 2675, 2803, 2908, 2943, 2991, 3027, 3052, 3059, 3099, 3120, 3149, 3274, 3284, 3362], 'treating': [113], 'severely': [114], 'narrowed': [115], 'blood': [116, 313], 'vessels,': [117], 'long-term': [118, 941, 1374], 'success': [119], 'is': [120, 126, 214, 298, 493, 539, 575, 612, 640, 797, 1004, 1054, 1097, 1222, 1298, 1450, 1464, 1483, 1492, 1511, 1657, 1661, 1665, 1684, 1702, 1738, 1773, 1797, 1917, 1942, 1981, 2039, 3379], 'often': [121], 'compromised': [122], 'by': [123, 195, 227, 419, 683, 748, 881, 1043, 1048, 1171, 1175, 1195, 1300, 1312, 1394, 1415, 1424, 1605, 1792, 1813, 1822, 1974, 2601, 2706, 2752, 2791, 2866, 3087, 3278, 3320, 3343], 'restenosis.': [124, 623, 700, 810, 860, 2221, 2644, 2811], 'It': [125, 1221, 1339, 1581, 1656], 'unclear': [127], 'what': [128], 'mechanisms': [129], 'cause': [130], 'vessels': [131, 589, 1603, 2048], 'renarrow,': [133, 2049], 'despite': [134], 'numerous': [135], 'studies': [136, 196, 397, 1366, 2009], 'involving': [137], 'patients': [138, 714], 'experimental': [140], 'animal': [141, 359, 627, 807, 857, 921], 'models': [142, 360, 582, 628, 858, 922, 2034], 'arterial': [144, 159, 261, 1207, 1579, 2840, 2934], 'injury.': [145, 1682, 2841], 'Although': [146, 784, 977, 1971], 'neointimal': [147, 204, 243, 746, 762, 770, 836, 854, 1199, 1285, 2354, 2636, 2837, 3022, 3176], 'thickening': [148, 205, 2593, 2838, 3177], 'was': [149, 764, 1201, 1243, 1317, 1413, 1436, 1572, 1644, 1717], 'initially': [150, 981], 'considered': [151], 'major': [153], 'cause,': [154], 'recent': [155, 378], 'evidence': [156, 509, 669], 'suggests': [157], 'that': [158, 210, 233, 520, 541, 642, 688, 734, 895, 927, 997, 1025, 1102, 1343, 1526, 1659, 1664, 2059], 'constriction,': [160], 'adventitial': [161], 'thickening,': [162], 'or': [163, 361, 664, 940, 973, 1079, 1238, 1723, 1767, 1853, 2086, 2093, 2112, 2123, 2519, 2800, 2980], 'both': [164, 1668, 1832, 1857], 'may': [165, 391, 411, 548, 633, 866, 943, 1144, 1152, 1214, 1678, 1760, 1846, 2053], 'be': [166, 323, 399, 417, 549, 570, 634, 1046, 1145, 1153, 1215, 1264, 1368, 1531, 1584, 1636, 1762, 1787, 1820, 2006, 2071, 2108], 'critical': [167, 475, 852], 'restenosis': [170, 191, 259, 321, 372, 492, 584, 703, 1231, 1628, 1994, 2036, 2315, 2471, 2525, 2558, 2881, 2939], 'process.': [171, 3418], 'The': [172, 185, 555, 838, 1040, 1505, 1622, 1638, 3077], 'geometric': [173], 'changes': [174], 'vessel': [176, 263, 307, 2801], 'expansion': [177], 'contraction': [179], 'constitute': [180], 'definition': [182], 'remodeling.': [184], 'present': [186], 'emphasis': [187, 467], 'on': [188, 468, 622, 1111, 1138, 1156, 1230, 1379, 1902, 1993, 2021, 2311, 2524, 2712, 3081], 'remodeling': [189, 235, 2169, 2203, 2664], 'has': [192, 704, 790, 885, 1340, 1815, 1837, 1896], 'been': [193, 356, 791, 886, 1341, 1816, 1839, 1897], 'driven': [194], 'failing': [197], 'show': [199, 507, 733], 'direct': [201], 'correlation': [202], 'between': [203, 303, 1334, 1831, 1946], 'lumen': [207], 'size,': [208], 'suggesting': [209], 'intimal': [211, 463, 2256, 2592], 'mass': [212, 1435], 'alone': [213, 1745], 'insufficient': [215, 553], 'explain': [217], 'narrowing.1': [218], 'Analyses': [219], 'human': [221, 403, 491, 681, 2205, 2867, 2873, 3285], 'sites': [224], 'at': [225, 480, 500, 1203, 1211, 1319, 3243], 'autopsy': [226, 678], 'our': [228, 1986], 'laboratory': [229], 'support': [230, 671], 'thesis': [232], 'constrictive': [234], 'initial': [238], 'plaque': [239, 620, 1536, 1556], 'burden,': [240], 'rather': [241, 425, 717], 'than': [242, 426, 657, 718], 'formation,': [244], 'are': [245, 384, 529, 992, 1023, 1068, 2079, 2097, 2105, 2936, 3309], 'responsible': [246], 'failure': [249, 395], 'angioplasty.2': [251], 'Other': [252, 1841], 'potential': [253, 787], 'contributors': [254], 'pathophysiology': [257], 'include': [260, 1115], 'spasm,': [262], 'recoil,': [264], 'platelet': [265, 1172, 2701], 'aggregation,': [266], 'thrombus': [268], 'formation.Arterial': [269], 'injury': [270, 755, 1165, 1600, 3026], 'evokes': [271], 'sequence': [273], 'events,': [275], 'consisting': [276, 1612], 'medial': [278, 772], 'smooth': [279, 526, 559, 873, 1184, 1619, 1808, 2355, 2759, 2869, 3062, 3083], 'muscle': [280, 527, 560, 874, 1185, 1620, 2216, 2356, 2760, 2870, 3063, 3084], 'cell': [281, 488, 512, 561, 875, 1125, 1139, 1642, 1652, 1736, 1931, 1938, 2028, 2357, 2606, 2761, 3085, 3122, 3179, 3270], 'activation,': [282], 'migration': [283, 562, 876, 1180, 2217, 3058], 'proliferation,': [285, 3303], 'matrix': [287, 1190], 'secretion': [288], 'culminating': [289], 'thickened': [292], 'neointima.3': [293], 'This': [294, 415, 514, 1128, 1412, 1543, 1700], 'series': [295], 'events': [297, 1472], 'linked': [299, 1898], 'complex': [301, 2033], 'interactions': [302], 'cells': [304, 314, 528, 2871, 3318], 'within': [305, 591], 'wall': [308], 'as': [309, 311, 333, 457, 615, 766, 831, 879, 884, 983, 994, 1072, 1271, 1279, 1281, 1405, 1407, 1732, 1747, 1871, 2110], 'well': [310, 495, 1280, 1587, 1739], 'circulating': [312], 'cytokines.': [316], 'At': [317], 'least': [318, 481], 'theory,': [320], 'should': [322, 430, 916, 1367], 'treatable': [325], 'process': [326, 598], 'with': [327, 465, 644, 662, 695, 889, 937, 1218, 1277, 1438, 1456, 1480, 1517, 1630, 1720, 1894, 2026, 2051, 2415, 2979], 'adjunctive': [328], 'pharmacotherapy.': [329], 'Several': [330], 'agents,': [331, 380], 'such': [332, 1071, 1270, 1870], 'vascular': [334, 469, 872, 1059, 1778, 1807, 1969, 2001, 2248, 2758, 2868, 3061, 3082, 3102, 3121, 3143], 'endothelial': [335, 2249], 'growth': [336, 456, 878, 1939, 2250, 2832], 'factor,4': [337], 'heparin,5': [338], 'paclitaxel,67': [339], 'urokinase,8': [340], 'recombinant': [341, 2463], 'hirudin,9': [342], 'colchicine,1011': [343], 'rapamycin': [344], 'sirolimus,1213': [345], 'cytochalasin': [346, 2670], 'B,14': [347], 'IIb': [348], 'IIIa': [350], 'inhibitors,15': [351], 'antisense': [353, 2754, 2789, 2864, 2878], 'oligomers,16171819': [354], 'have': [355, 367, 449, 1562, 1679], 'tested': [357], 'patients.': [362], 'Most': [363], 'these': [365, 447, 841, 978, 1521], 'agents': [366, 448, 3280], 'failed': [368], 'solve': [370], 'problem': [373], 'humans,': [375, 596], 'but': [376, 1445, 1758, 3383], 'two': [377], 'promising': [379], 'paclitaxel': [381, 2386, 3174], 'rapamycin,': [383], 'trials': [387, 918], 'Europe.Several': [389], 'factors': [390], 'contribute': [392], 'translated': [400], 'into': [401], 'successful': [402], 'trials.': [404], 'Difficulties': [405], 'achieving': [407], 'appropriate': [409], 'dose': [410], 'offer': [412], 'one': [413, 1523], 'explanation.': [414], 'can': [416, 1045, 1130, 1263, 1351, 1590, 1743, 1862, 2064, 3239], 'remedied': [418], 'localized': [420, 1428, 1549, 1567], 'delivery': [421, 736, 1550, 1568, 2246, 2387, 2513, 2634, 2668, 2786, 3172], 'drug': [424, 1219, 2530], 'systemic': [427], 'administration,': [428], 'which': [429, 547, 558, 1053, 1114, 1143, 1212, 1259, 1350], 'help': [431, 2054], 'attain': [432], 'high': [433], 'concentrations': [434], 'while': [435], 'limiting': [436], 'side': [438], 'effects': [439, 1093, 1135, 1149, 1227, 1347, 1375, 1400, 1623, 1866, 1901, 1965, 2394, 2523, 3078], 'potentially': [441], 'toxic': [442], 'agents.': [443], 'Alternatively,': [444], 'most': [445], 'generally': [450, 585], 'targeted': [451], 'reduction': [453, 781, 1235], 'tissue': [455], 'means': [459], 'suppressing': [461], 'hyperplasia,': [464], 'little': [466, 613, 1705], 'remodeling,': [470], 'factor': [472, 2251, 2833], 'perhaps': [473], 'more': [474, 654, 1363, 1540, 2032], 'restenotic': [478, 535, 566, 2911], 'process,': [479], 'PTCA.': [483], 'Moreover,': [484, 1485, 1827, 1944], 'importance': [486, 845, 1706], 'proliferation': [489, 521, 1182, 1643, 1932, 2637, 2762], 'not': [494, 518, 523, 899, 1253, 1446, 1718, 2080, 2106, 2796, 3310, 3384], 'supported;': [496], 'atherectomy': [498, 2913], 'specimens': [499], 'various': [501, 990], 'intervals': [502], 'after': [503, 752, 1206, 1289, 1307, 1325, 1410, 1427, 2170, 2316, 2359, 2420, 2472, 2559, 2594, 2672, 2717, 2839, 2882, 2940, 3024], 'PTCA': [504, 719], 'fail': [505], 'increased': [511, 650, 1512, 2416], 'proliferation.20': [513], 'observation,': [515], 'however,': [516], 'does': [517, 522, 2795], 'mean': [519], 'occur.': [524], 'Obviously,': [525, 1770], 'dominant': [531], 'cellular': [532, 1000, 1106, 1353, 1471, 1681], 'element': [533], 'lesions;': [536], 'hence,': [537], 'it': [538, 639, 1759], 'conceivable': [540, 641], 'replication': [542, 1670], 'occurs': [543], 'transient': [545], 'periods,': [546], 'overlooked': [550], 'because': [551, 710, 1689, 1712], 'sampling.': [554], 'extent': [556, 1160], 'contributes': [563], 'lesion': [567, 3249], 'must': [568], 'also': [569, 944, 1055, 1388, 1685, 1761, 1838, 1863], 'weighed.Another': [571], 'point': [572], 'consider': [574], 'course': [577], 'disease.': [580], 'Animal': [581], 'consist': [586, 958], 'nonatherosclerotic': [588], 'studied': [590, 1202], 'weeks': [592, 751, 1205], 'injury;': [594, 1326], 'this': [597, 673, 725, 796, 914, 1296, 1331, 1459, 1980, 2077], 'typically': [599], 'develops': [600], 'over': [601], '6': [602, 1305], 'months.': [603], 'Finally,': [604, 1566, 1890], 'reference': [606], 'underlying': [609, 630, 1631], 'disease,': [610], 'there': [611, 1067], 'information': [614], 'influence': [618], 'substrate': [621, 2932], 'In': [624, 930, 1061, 1192, 1309, 1391, 1789], 'other': [625, 1765, 1878, 1952], 'words,': [626], 'without': [629, 2981], 'atherosclerotic': [631, 1481, 1490, 1594, 1632, 2874, 3248], 'disease': [632, 1482, 1633], 'overly': [635], 'simplistic.': [636], 'For': [637], 'example,': [638, 1258], 'plaques': [643, 661], 'large': [646], 'lipid': [647, 666, 689], 'core': [648, 690], 'inflammation': [651, 693, 1316, 1354, 1380], 'provide': [652], 'reactive': [655], 'environment': [656], 'relatively': [658, 1615], 'acellular': [659], 'fibrous': [660, 1541], 'small': [663], 'absent': [665], 'cores.': [667], 'Preliminary': [668], 'hypothesis': [674], 'comes': [675], 'from': [676, 1033, 1099, 1501, 1930], 'an': [677, 706, 804, 816, 906, 910, 965, 1439, 1477, 1647, 1694, 1713, 1828], 'study': [679, 722, 800, 915, 1194, 1311, 1973], 'stents': [682, 716, 3148], 'et': [685, 731, 1197, 1314, 1396, 1607, 1794, 1976], 'al,21': [686], 'demonstrating': [687, 801], 'size': [691, 2802], 'correlate': [694], 'neointima': [696, 1237, 1611, 2764, 2798], 'formation': [697, 1200, 1286, 2799], 'greater': [699, 938, 1532], 'Today,': [701], 'in-stent': [702], 'become': [705], 'emerging': [707], 'problem,': [709], '≈80%': [711], 'receive': [715], 'alone.22In': [720], 'published': [723], 'issue': [726], 'Circulation': [728], 'Research,': [729], 'Charles': [730, 1196, 1313, 1395, 1606, 1793, 1975, 3002], 'al23': [732, 1608, 1977], 'local': [735, 2667, 2785], 'C6-ceramide,': [738], 'cell-permeable': [740, 1069], 'bioactive': [741], 'analog': [742, 1423], 'ceramide,': [744, 1066], 'reduces': [745, 2635, 2836], 'hyperplasia': [747, 855, 2257, 3023], '50%': [749, 1417], '2': [750, 1204], 'balloon': [753, 1599, 2318, 2595, 2793, 3019], 'stretch': [754, 3025], 'rabbit': [758, 1292, 1598], 'carotid': [759, 1709, 2261, 3028], 'artery.23': [760], 'When': [761], 'stenosis': [763], 'quantified': [765], 'ratio': [768], 'cross-sectional': [773], 'areas,': [774], 'ceramide': [775, 789, 813, 896, 1003, 1027, 1086, 1109, 1137, 1151, 1229, 1377, 1387, 1402, 1422, 1434, 1463, 1487, 1506, 1528, 1553, 1560, 1571, 1589, 1625, 1731, 1744, 1771, 1796, 1814, 1844, 1895, 1916, 1967, 1992, 2004, 2025], 'treatment': [776, 897, 1378], 'resulted': [777, 814], '92%': [780], 'stenosis.': [783], 'growth-arresting': [786], 'shown': [792, 887, 1342, 1818], 'previously': [793], 'culture,': [795], 'first': [799, 1983], 'efficacy': [802, 2396, 2427], 'vitro': [806], 'model': [808, 1332, 1596, 1629, 2642, 2808], 'Administration': [811], 'early': [817, 1406], 'inhibition': [818, 1848, 1936], 'extracellular': [820, 3200], 'signal–related': [821], 'kinase': [822, 828, 1050, 1360, 1855, 3202, 3206, 3341, 3377], '(ERK)': [823], 'phosphorylation': [825], 'protein': [827, 1359, 1663, 1854, 3205, 3340], 'B': [829, 2671], '(PKB/Akt)': [830], 'mechanism': [833], 'decreased': [835], 'formation.': [837, 2765], 'downregulation': [839], 'activities': [842], 'highlights': [843], 'their': [844], 'mitogenic': [848], 'cell-survival': [850], 'pathways': [851, 870, 1836, 1842, 1954, 2058], 'Activation': [861], 'PKB/Akt': [863, 1802, 1812], 'ERK': [865, 1804, 1835], 'represent': [867, 1232], 'common': [868], 'signaling': [869, 1399, 1737, 1772, 1805, 1845, 1953, 2057, 3123], 'shared': [880], 'several': [882], 'agonists,': [883], 'recently': [888, 1817], 'angiotensin': [890, 3088], 'II.2425': [891], 'Pathological': [892, 1241], 'analysis': [893], 'demonstrated': [894], 'did': [898], 'provoke': [900], 'inflammation,': [901, 1176], 'desirable': [903], 'property': [904], 'antirestenotic': [907], 'drug.': [908], 'As': [909], 'important': [911], 'practical': [912], 'application,': [913], 'prompt': [917], 'larger': [920], 'restenosis,': [924], 'including': [925, 1881], 'those': [926, 2082], 'involve': [928, 1847], 'stents.': [929], 'addition,': [931], 'development': [933, 2066], 'ceramide-like': [935], 'analogs': [936, 1087], 'potency': [939], 'retention': [942], 'prove': [945], 'beneficial.Ceramide:': [946], 'Metabolism': [947], 'CatabolismCeramide': [949], 'forms': [950], 'central': [952], 'molecule': [953, 1914], 'all': [955, 1575], 'sphingolipids.2627': [956], 'Sphingolipids': [957, 3098], 'long-chain': [961], 'amino-dialcohol': [962], 'base': [963, 1036], '(sphingoid),': [964], 'amide-linked': [966], 'fatty': [967, 1031], 'acyl': [968], 'group,': [969], 'polar': [972], 'glycosidic': [974], 'head': [975], 'group.': [976], 'molecules': [979], 'were': [980, 1252, 1403], 'characterized': [982], 'serving': [984], 'structural': [986, 1766], 'role': [987, 3047], 'membranes,': [989], 'derivatives': [991], 'recognized': [993, 1658], 'second': [995, 1749], 'messengers': [996], 'possess': [998], 'diverse': [999], 'responses.': [1001], 'Endogenous': [1002], 'generated': [1005], 'through': [1006, 2008], 'activation': [1008, 1356, 1876, 1908, 3086, 3388], 'distinct': [1010], 'sphingomyelinases': [1011], 'residing': [1012], 'separate': [1014], 'subcellular': [1015], 'compartments': [1016], 'response': [1018, 1169, 1329, 1752, 3144], 'specific': [1020, 1964, 2027], 'stimuli.': [1021], 'Ceramidases': [1022], 'enzymes': [1024], 'hydrolyze': [1026, 3240], 'liberate': [1029], 'acid': [1032, 3236], 'sphingoid': [1035], 'form': [1038], 'sphingosine.': [1039], 'sphingosine': [1041, 1049, 1449], 'released': [1042], 'ceramidases': [1044], 'phosphorylated': [1047, 1448], 'sphingosine-1-phosphate,': [1052], 'biologically': [1056, 1452], 'active': [1057, 1453], 'cells.': [1060, 1621, 3064], 'addition': [1062], 'parent': [1065, 1421], 'analogs,': [1070], 'C2-ceramide': [1073], '(d-erythro-sphingosine,': [1074, 1077, 1081], 'N-acetyl),': [1075], 'C6-ceramide': [1076], 'N-hexanoyl),': [1078], 'C8-ceramide': [1080], 'N-octanoly).': [1082], 'These': [1083], 'exogenous': [1084, 1552, 1588], 'cell-permeant': [1085], 'mimic': [1088, 1345, 1864], 'many': [1089, 1112, 1781, 1922], 'biological': [1092, 2393], 'natural': [1095, 1559], 'ceramide.It': [1096], 'apparent': [1098, 1404, 1829], 'literature': [1101], 'specificity': [1104], 'responses': [1107, 1928], 'depends': [1110], 'factors,': [1113], 'nature': [1117], 'stimulus,': [1120], 'costimulatory': [1121], 'signals,': [1122], 'type': [1126], 'involved.': [1127], 'diversity': [1129, 1729], 'result': [1131], 'varied': [1134], 'function,': [1140], 'some': [1141, 1261, 1998], 'proatherogenic.2627': [1146], 'Therefore,': [1147, 1362], 'differential': [1148], 'observed,': [1154], 'depending': [1155], 'dosing': [1158, 1385], 'hypercholesterolemia.Healing': [1162], 'RestenosisArterial': [1164], 'produces': [1166, 1609], 'wound-healing': [1168], 'initiated': [1170], 'deposition': [1173], 'followed': [1174], 'angiogenesis,': [1177], 'granulation': [1178], 'tissue,': [1179], 'cells,': [1186], 'synthesis': [1188, 3056], 'molecules.': [1191, 1769], 'al,23': [1198, 1315, 1397, 1795], 'injury,': [1208], 'time': [1210], 'healing': [1213, 1302, 1382], 'incomplete,': [1216], 'especially': [1217, 2030], 'treatment.': [1220], 'unknown': [1223], 'whether': [1224, 1548], 'beneficial': [1226], 'true': [1234], 'delayed': [1239], 'healing.': [1240], 'examination': [1242], 'restricted': [1244], 'hematoxylin': [1246], 'eosin–stained': [1248], 'slides;': [1249], 'special': [1250], 'stains': [1251], 'done': [1254], 'fibrin,': [1256], 'instances': [1262], 'mistaken': [1265], 'collagen.28Other': [1267], 'antiproliferative': [1268, 1278, 2917], 'drugs,': [1269], 'paclitaxel,': [1272], 'novel': [1274], 'antimicrotubular': [1275], 'agent': [1276], 'antimigratory': [1282], 'properties,': [1283], 'decreases': [1284], '28': [1287], 'days': [1288], 'stenting': [1290, 2942], 'iliac': [1293], 'arteries.': [1294, 2207, 3029], 'However,': [1295], 'effect': [1297, 1701], 'accompanied': [1299, 1414], 'incomplete': [1301], 'up': [1303, 1321], 'months': [1306], 'stenting.29': [1308], 'assessed': [1318], 'only': [1320, 1742, 2062], '60': [1323, 1425], 'minutes': [1324, 1409, 1426], 'inflammatory': [1328], 'peaks': [1333], '3': [1335], '5': [1337], 'days.23': [1338], 'ceramides': [1344], 'cytokines,': [1349, 1869], 'induce': [1352, 1693], 'via': [1355], 'stress-activated': [1358, 3204], 'cascades.30': [1361], 'detailed': [1364], 'pathological': [1365], 'carried': [1369], 'out': [1370], 'determine': [1372], 'vivo.The': [1384], 'deserves': [1389], 'comment.': [1390], 'report': [1393], '15': [1408], 'dosing.': [1411], 'loss': [1418], 'delivery.': [1429, 2531], 'Curiously,': [1430], 'decrease': [1432, 1640], 'associated': [1437, 1455, 1719, 1893], 'increase': [1440, 1714], 'gangliosides': [1442], 'cerebrosides': [1444], 'sphingosines;': [1447], 'metabolite': [1454], 'prothrombogenic': [1457], 'effects.27Whether': [1458], 'short': [1460], 'half-life': [1461], 'enough': [1465], 'sustain': [1467], 'wave': [1469], 'presence': [1475], 'injured': [1478], 'artery': [1479, 2807], 'debatable.': [1484], 'content': [1488], 'lesions': [1491], 'markedly': [1493], 'elevated': [1494], 'relative': [1495, 1537], 'normal': [1497, 1602], 'arteries,': [1498], 'part': [1500], 'LDL': [1503, 1510], 'content.': [1504], 'concentration': [1507], 'lesional': [1509], '10-': [1513], '50-fold': [1515], 'compared': [1516], 'plasma': [1518], 'LDL.31': [1519], 'data,': [1522], 'would': [1524, 1530, 1561], 'assume': [1525], 'levels': [1529], 'lipid-rich': [1535], 'lesion.': [1542], 'poses': [1544], 'question': [1546], 'abundant': [1557], 'any': [1563], 'additional': [1564], 'effects.': [1565], 'radiolabeled': [1570], 'observed': [1573], 'throughout': [1574], 'layers': [1576], 'media.': [1580], 'remains': [1582], 'determined': [1585], 'how': [1586, 2047], 'penetrate': [1591], 'well-collagenized': [1593], 'plaque.The': [1595], 'used': [1604], 'homogeneous': [1616], 'population': [1617], 'need': [1634, 1785], 'explored.': [1637], 'ceramide-induced': [1639, 1947, 3382], 'measured': [1645], 'using': [1646, 2010, 2037], 'antibody': [1648, 2710], 'directed': [1649], 'against': [1650], 'proliferating': [1651, 3269], 'nuclear': [1653, 1882, 3271], 'antigen': [1654, 3272], '(PCNA).': [1655], 'PCNA': [1660, 1676, 1683], 'required': [1666, 3311, 3380], 'DNA': [1669, 1672, 1690, 1697, 3055, 3275, 3304], 'repair32': [1673], ';': [1674], 'positive': [1675], 'staining': [1677], 'represented': [1680], 'upregulated': [1686], 'during': [1687, 3415], 'apoptosis,': [1688], 'strand': [1691], 'breaks': [1692], 'ultimately': [1695], 'futile': [1696], 'repair': [1698, 3276], 'process.33': [1699], 'probably': [1703], 'stretch-injury': [1710], 'model,': [1711], 'apoptosis': [1716, 1941], 'either': [1721], 'control': [1722], 'ceramide-treated': [1724], 'animals.Ceramide': [1725], 'Intracellular': [1727], 'SignalingThe': [1728], 'messenger': [1734, 1750], 'established.': [1740], 'Not': [1741], 'serve': [1746], 'variety': [1755], 'stimuli,': [1757], 'converted': [1763], 'effector': [1768], 'nascent': [1775], 'area': [1776], 'research,': [1779], 'its': [1783, 1900], 'actions': [1784, 1990], 'identified.': [1788], 'article': [1791], 'potent': [1799], 'inhibitor': [1800], 'muscle.': [1809], 'Inhibition': [1810, 2590], 'mediated': [1821], 'dephosphorylation': [1823, 3345], 'serine': [1825, 3347], '473.34': [1826], 'crosstalk': [1830, 1945], 'PKB/Ark': [1833], 'recognized.35': [1840], 'Ca2+-activated': [1850], 'K+': [1851], 'channels': [1852], 'C,': [1856, 2161, 2230, 2232, 2283, 2292, 2370], 'promoters': [1858], 'vasodilation.': [1860], 'certain': [1868], 'tumor': [1872, 3385], 'necrosis': [1873, 3386], 'factor-α,': [1874], 'causing': [1875], 'regulatory': [1879], 'mediators,': [1880], 'factor-κB,': [1883], 'activator': [1884], 'protein-1,': [1885], 'c-Jun': [1887], 'N-terminal': [1888], 'kinase.36': [1889], 'cytotoxicity': [1892], 'mitochondrial': [1903], 'membrane': [1904, 3413], 'permeability': [1905], 'downstream': [1907], 'caspases.37SummaryHow': [1910], 'structurally': [1912], 'simple': [1913], 'like': [1915], 'able': [1918], 'mediate': [1920], 'so': [1921], 'different,': [1923], 'sometimes': [1925], 'paradoxical,': [1926], 'physiological': [1927], 'ranging': [1929], 'differentiation': [1934], 'unknown.': [1943], 'signal': [1948], 'transduction': [1949], 'cascades': [1950], 'will': [1955], 'add': [1956], 'inherent': [1959], 'difficulty': [1960], 'distinguishing': [1962], 'biology.': [1970, 3103], 'shows': [1978], 'promise,': [1979], 'step': [1984], 'toward': [1985], 'understanding': [1987, 2045], 'vivo.': [1996, 2398], 'Clearly,': [1997], 'targets': [2002], 'could': [2005], 'clarified': [2007], 'animals': [2011], 'harboring': [2012], 'disrupted': [2013], 'genes': [2014], 'sphingolipid': [2016], 'metabolism.': [2017], 'More': [2018, 2041], 'extensive': [2019], 'research': [2020], 'interaction': [2023], 'types,': [2029], 'stents,': [2038, 2052], 'needed.': [2040], 'importantly,': [2042], 'clearer': [2044], 'particularly': [2050], 'decipher': [2055], 'promote': [2060], 'restenosis;': [2061], 'then': [2063], 'new': [2068], 'therapeutic': [2069], 'strategies': [2070], 'clinically': [2072], 'effective.The': [2073], 'opinions': [2074, 2092], 'expressed': [2075], 'editorial': [2078], 'necessarily': [2081], 'editors': [2085], 'American': [2089, 3443], 'Heart': [2090, 2209, 2433, 2493, 3444], 'Association.The': [2091], 'assertions': [2094], 'contained': [2095], 'herein': [2096], 'private': [2099], 'views': [2100, 2114], 'authors': [2103], 'construed': [2109], 'official': [2111], 'reflecting': [2113], 'Departments': [2117], 'Army,': [2120], 'Air': [2121], 'Force,': [2122], 'Defense.FootnotesCorrespondence': [2124], 'Virmani,': [2127], 'MD,': [2128], '6825': [2138], '16th': [2139], 'St': [2140], 'NW,': [2141], 'DC': [2143], '20306-6000.': [2144], 'E-mail': [2145], '[email': [2146], 'protected]': [2147], 'References': [2148], '1': [2149], 'Mintz': [2150], 'GS,': [2151], 'Popma': [2152, 2655], 'JJ,': [2153, 2448, 2656], 'Pichard': [2154], 'AD,': [2155], 'Kent': [2156], 'KM,': [2157, 2692, 3333], 'Satler': [2158], 'LF,': [2159], 'Wong': [2160], 'Hong': [2162], 'MK,': [2163], 'Kovach': [2164], 'JA,': [2165, 2658], 'Leon': [2166, 2629], 'MB.': [2167, 2630], 'Arterial': 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