The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

Name: Work Video:
Duration: 3 min 30 s
Lotta Johansson; Jane S. Thomsen; Anastasios Damdimopoulos; Giannis Spyrou; Jan-Ακε Gustafsson; Eckardt Treuter
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'abstract_inverted_index': {'SHP': [0, 31, 71, 86, 104, 117, 136, 147, 159, 173, 179, 210, 250, 265, 283, 296, 315, 326, 338, 352, 2407, 2533, 2540, 2578, 2638, 2650, 2778, 3227, 3237, 3906, 3912, 3965, 4270, 4288, 4360, 4370], '(short': [1, 180, 2408], 'heterodimer': [2, 181, 385, 2409], 'partner)': [3, 182], 'is': [4, 119, 137, 167, 183, 298, 316, 346, 493, 1031, 1307, 1440, 2417, 2530, 4289], 'an': [5, 184, 2324, 3180, 3881, 3930, 4213], 'unusual': [6, 185, 2325], 'orphan': [7, 186, 771, 2326, 2402, 2419, 2432, 4267], 'nuclear': [8, 42, 115, 139, 176, 187, 221, 294, 318, 355, 405, 620, 2322, 2335, 2551, 2640, 4268, 4363], 'receptor': [9, 25, 43, 177, 188, 204, 222, 356, 366, 368, 372, 398, 401, 797, 2327, 2403, 2420, 2433, 2552, 2622, 2641, 4269], 'that': [10, 70, 135, 163, 189, 249, 314, 342, 746, 1233, 1305, 1597, 2331, 3283, 4174, 4359], 'contains': [11, 190, 2339, 2423], 'a': [12, 18, 38, 107, 138, 142, 168, 191, 197, 217, 286, 317, 321, 347, 494, 696, 702, 708, 717, 723, 751, 1022, 1309, 1579, 1594, 2334, 2340, 2424, 2547, 2633, 2822, 2878, 2895, 3241, 3284, 3394, 3398, 3480, 3786, 3816, 3833, 4151, 4305, 4362], 'putative': [13, 192, 2126, 2341], 'ligand-binding': [14, 193, 362], 'domain': [15, 92, 194, 271, 361, 363, 699, 715, 726, 2320, 2677, 2760], 'but': [16, 195, 2338], 'lacks': [17, 196, 2333, 4361], 'conserved': [19, 198, 710, 1462, 2135, 4291], 'DNA-binding': [20, 199, 360, 714, 2676, 4365], 'domain.': [21, 200, 4366], 'Although': [22, 201, 1382, 2528], 'no': [23, 202], 'conventional': [24, 203], 'function': [26, 205, 359, 706, 805, 1322, 2444], 'has': [27, 32, 206, 211, 2328, 2404, 2534, 2541, 2579, 2908, 3020], 'yet': [28, 207], 'been': [29, 33, 208, 212, 514, 779, 802, 1172, 1246, 1636, 2329, 2405, 2542, 2580, 2734, 2909, 3021, 3048, 3739], 'identified,': [30, 209], 'proposed': [34, 213], 'to': [35, 214, 487, 604, 622, 804, 819, 1163, 1176, 1211, 1248, 1392, 1577, 1592, 1638, 2009, 2016, 2140, 2393, 2544, 2582, 2592, 2802, 3460, 3647, 3778, 3893, 3901, 3929, 3935, 4170, 4221, 4348], 'act': [36, 215, 2545], 'as': [37, 101, 157, 216, 280, 336, 767, 769, 806, 1048, 1471, 1473, 1588, 2141, 2282, 2284, 2546, 2620, 2855, 2936, 3254, 3325, 3357, 3587, 3606, 3691, 3847, 3919, 4091], 'negative': [39, 111, 218, 290, 2548], 'regulator': [40, 219, 2549], 'of': [41, 57, 98, 110, 145, 220, 236, 277, 289, 324, 419, 483, 501, 598, 626, 755, 1159, 1214, 1312, 1388, 1452, 1568, 1573, 1601, 1756, 1996, 2124, 2229, 2242, 2321, 2427, 2550, 2632, 2649, 2694, 2727, 2776, 2793, 2812, 2837, 2864, 2877, 2885, 2902, 2977, 3014, 3194, 3225, 3234, 3260, 3319, 3334, 3342, 3387, 3408, 3418, 3453, 3483, 3619, 3625, 3632, 3640, 3772, 3832, 3837, 3844, 3884, 3964, 4006, 4080, 4086, 4179, 4212, 4224, 4301, 4309, 4369], 'signaling': [44, 223, 2553], 'pathways,': [45, 224], 'because': [46, 225, 1045, 2577], 'it': [47, 226, 2529], 'interacts': [48, 72, 227, 251, 2429], 'with': [49, 74, 149, 228, 253, 328, 423, 793, 821, 1156, 1174, 1224, 1254, 1325, 1442, 2120, 2317, 2397, 2430, 2557, 3248, 3300, 3306, 3309, 3404, 3486, 3494, 3519, 3557, 3574, 3585, 3602, 3629, 3785, 3880, 4061, 4077, 4083, 4111, 4125, 4143, 4176, 4293, 4304, 4314], 'and': [50, 54, 64, 79, 81, 94, 130, 161, 229, 233, 243, 258, 260, 273, 309, 340, 585, 722, 733, 750, 764, 823, 918, 1018, 1058, 1086, 1110, 1144, 1235, 1252, 1259, 1335, 1363, 1559, 1754, 2000, 2015, 2249, 2390, 2435, 2442, 2525, 2536, 2643, 2651, 2665, 2671, 2684, 2731, 2765, 2791, 2844, 3056, 3082, 3107, 3148, 3488, 3500, 3532, 3539, 3564, 3581, 3661, 3734, 3782, 3809, 3825, 3891, 3988, 3994, 4002, 4029, 4035, 4043, 4067, 4123, 4261, 4296, 4299], 'inhibits': [51, 82, 230, 261, 2639], 'DNA': [52, 231, 616, 1261, 2672, 3652], 'binding': [53, 97, 232, 276, 603, 730, 1119, 1572, 3462], 'transcriptional': [55, 84, 234, 263, 506, 735, 1147, 1326, 1998], 'activity': [56, 235, 625, 1999, 2002, 3690], 'various': [58, 237, 1383, 2398], 'nonsteroid': [59, 238, 756, 783, 1313, 2399], 'receptors,': [60, 77, 239, 256, 772, 2323, 2400], 'including': [61, 125, 240, 304, 758, 1320, 1328, 1477], 'thyroid': [62, 241, 399, 761], 'hormone': [63, 242, 400], 'retinoid': [65, 244, 364, 795], 'receptors.': [66, 116, 245, 295, 592], 'We': [67, 246, 2626], 'show': [68, 247], 'here': [69, 248], 'directly': [73, 252], 'agonist-bound': [75, 254], 'estrogen': [76, 127, 255, 306, 367, 1151, 2655], 'ERα': [78, 257, 1057, 1234, 3055, 3603, 3634], 'ERβ,': [80, 259], 'ER-mediated': [83, 262, 2235], 'activation.': [85, 178, 264, 357], 'specifically': [87, 266], 'targets': [88, 160, 267, 339, 2623], 'the': [89, 146, 268, 325, 416, 499, 624, 790, 794, 816, 1027, 1157, 1212, 1386, 1446, 1450, 1465, 1478, 1564, 1599, 1757, 2011, 2121, 2125, 2227, 2240, 2318, 2415, 2418, 2431, 2630, 2695, 2724, 2777, 2781, 2787, 2803, 2809, 2826, 2851, 2857, 2882, 2899, 2969, 2974, 3007, 3011, 3149, 3184, 3191, 3231, 3249, 3258, 3293, 3317, 3338, 3413, 3438, 3454, 3461, 3590, 3609, 3657, 3680, 3767, 3773, 3779, 3896, 3902, 3910, 3916, 3921, 4094, 4177, 4182, 4222, 4266, 4357], 'ligand-regulated': [90, 269, 734], 'activation': [91, 270, 358, 705, 736, 1179, 1439, 2759, 4214], 'AF-2': [93, 272, 1456, 2131, 2652], 'competes': [95, 274], 'for': [96, 113, 165, 275, 292, 344, 498, 590, 728, 760, 773, 1166, 1581, 1642, 1645, 2226, 2233, 2313, 2559, 2624, 2629, 2856, 3054, 3245, 3257, 3316, 3431, 3688, 3791, 3801, 3806, 3812, 3830, 3842, 3876, 3920, 3972, 4014, 4117, 4130], 'coactivators': [99, 278, 1336, 1602, 2231, 2653], 'such': [100, 279, 1587], 'TIF2.': [102, 281], 'Thus,': [103, 282], 'may': [105, 174, 284, 353, 587, 618, 1237, 2590], 'represent': [106, 285], 'new': [108, 287, 2425], 'category': [109, 288], 'coregulators': [112, 291], 'ligand-activated': [114, 293], 'mRNA': [118, 297], 'widely': [120, 299], 'expressed': [121, 300], 'in': [122, 301, 380, 811, 1216, 1229, 1241, 1257, 1323, 1385, 2003, 2246, 2439, 2654, 3240, 3337, 3384, 3412, 3479, 3511, 3547, 3815, 3975, 3985, 3999, 4017, 4026, 4040, 4055, 4114, 4150, 4312], 'rat': [123, 302, 3250, 3285, 4216, 4287], 'tissues': [124, 303], 'certain': [126, 305, 782], 'target': [128, 307, 600], 'tissues,': [129, 308, 1230], 'subcellular': [131, 310], 'localization': [132, 311, 406, 4100], 'studies': [133, 312, 2289, 3353], 'demonstrate': [134, 313], 'protein,': [140, 319, 4235], 'suggesting': [141, 320], 'biological': [143, 322], 'significance': [144, 323], 'interactions': [148, 327, 3465], 'ERs.': [150, 329], 'Taken': [151, 330], 'together,': [152, 331], 'these': [153, 332, 1167, 2004], 'results': [154, 333], 'identify': [155, 334, 4171], 'ERs': [156, 335, 1114, 1321, 2619], 'novel': [158, 169, 337, 348, 2314, 2621, 2634, 4172], 'suggest': [162, 341, 1232, 2645], 'competition': [164, 343, 2556, 3439], 'coactivator-binding': [166, 345, 1457], 'mechanism': [170, 349, 2635], 'by': [171, 350, 602, 1033, 1053, 2555, 2636, 2667, 2690, 2772, 2806, 2820, 2849, 2874, 2893, 2967, 3005, 3178, 3222, 3383, 3450, 3468, 3473, 3589, 3596, 3608, 3795, 3981, 4022, 4093, 4148], 'which': [172, 351, 612, 774, 812, 1029, 1207, 1634, 2422, 2637], 'inhibit': [175, 354], 'X': [365, 796], 'estrogen-responsive': [369], 'element': [370, 497], 'steroid': [371, 744, 1043], 'coactivator': [373, 1582, 1759, 2127], '1': [374, 383, 3343, 3347, 3406, 3419, 3423, 3770, 3973, 4015], 'transcription': [375, 421, 597, 628, 693, 704, 809, 1330, 2013], 'intermediary': [376], 'factor': [377], '2': [378, 3792, 4078, 4084], 'amplified': [379], 'breast': [381, 2248], 'cancer': [382, 2251], 'short': [384, 2134], 'partner': [386, 4185], 'wild-type': [387], 'glutathioneS-transferase': [388], 'green': [389], 'fluorescent': [390], 'protein': [391, 403, 3411], 'reverse': [392], 'transcriptase-polymerase': [393], 'chain': [394], 'reaction': [395, 3780], 'peroxisome-proliferator': [396], 'activated': [397], 'receptor-interacting': [402], '140': [404], 'signal': [407], 'fetal': [408], 'calf': [409], 'serum': [410], 'amino': [411, 3524], 'acid(s).': [412], 'Nuclear': [413, 593, 689, 738, 1318], 'receptors': [414, 594, 621, 690, 739, 745, 757, 759, 784, 1039, 1044, 1314, 1319, 1384], 'comprise': [415], 'largest': [417], 'superfamily': [418, 2416], 'eucaryotic': [420], 'factors': [422, 629, 694, 810], 'more': [424], 'than': [425], '150': [426], 'proteins': [427, 2005, 2315, 3246, 3428, 4173], 'identified': [428, 515, 1021, 2618], '(for': [429, 1337, 4187], 'review,': [430], 'see': [431, 1339, 1765, 4189], 'Refs.': [432, 1340, 1766], '1Enmark': [433], 'E.': [434, 533, 572, 1064, 1094, 1128, 1785, 2145, 2210, 2509, 2511, 2738, 2913, 2981, 3025, 3110, 3263, 3360, 3712, 3745, 3853, 3942, 4192], 'Gustafsson': [435, 674, 906, 957, 1069, 1099, 1133, 1192, 1268, 1498, 1619, 2708, 2745, 2920, 2947, 2988, 3032, 3067, 3095, 3136, 3270, 3367, 3699, 3719, 3748, 3856, 3945, 4199], 'J.-Å.': [436, 675, 907, 958, 1070, 1100, 1134, 1193, 1269, 1499, 1620, 2709, 2746, 2921, 2948, 2989, 3033, 3068, 3096, 3137, 3271, 3368, 3700, 3720, 3749, 3857, 3946, 4200], 'Mol.': [437, 908, 1270, 1353, 1852, 2454, 2471, 2602, 2747, 2922, 2990, 3034, 3097, 3138, 3208, 3272, 3369, 3701, 3721, 4201], 'Endocrinol.': [438, 1271, 1354, 2748, 2923, 2991, 3035, 3098, 3139, 3273, 3370, 3702, 3722, 4202], '1996;': [439, 559, 653, 1010, 1078, 1355, 1551, 1671, 1701, 1732, 1814, 2055, 2074, 2350, 2568, 4248, 4278], '10:': [440, 1356], '1293-1307Crossref': [441], 'PubMed': [442, 458, 476, 544, 562, 580, 661, 684, 840, 865, 883, 899, 914, 936, 965, 988, 1013, 1081, 1105, 1139, 1202, 1275, 1299, 1358, 1377, 1402, 1433, 1506, 1529, 1554, 1627, 1679, 1704, 1735, 1749, 1779, 1797, 1817, 1839, 1858, 1890, 1913, 1942, 1963, 1989, 2045, 2058, 2082, 2113, 2157, 2179, 2202, 2219, 2277, 2306, 2353, 2380, 2460, 2477, 2503, 2520, 2571, 2608, 2718, 2752, 2927, 2957, 2995, 3039, 3077, 3102, 3122, 3143, 3169, 3214, 3277, 3374, 3706, 3726, 3761, 3869, 3958, 4206, 4256, 4281, 4340], 'Scopus': [443, 459, 477, 545, 563, 581, 662, 685, 841, 866, 884, 900, 937, 966, 989, 1014, 1082, 1106, 1140, 1203, 1276, 1300, 1359, 1378, 1403, 1434, 1507, 1530, 1555, 1628, 1680, 1705, 1736, 1750, 1780, 1798, 1818, 1840, 1859, 1891, 1914, 1943, 1964, 1990, 2046, 2059, 2083, 2114, 2158, 2180, 2203, 2220, 2278, 2307, 2354, 2381, 2461, 2478, 2504, 2521, 2572, 2609, 2719, 2753, 2928, 2958, 2996, 3040, 3078, 3103, 3123, 3144, 3170, 3215, 3278, 3375, 3707, 3727, 3762, 3870, 3959, 4207, 4257, 4282, 4341], '(192)': [444], 'Google': [445, 461, 479, 547, 565, 583, 664, 687, 843, 868, 886, 902, 915, 939, 968, 991, 1016, 1084, 1108, 1142, 1205, 1278, 1302, 1361, 1380, 1405, 1436, 1509, 1532, 1557, 1630, 1682, 1707, 1738, 1752, 1782, 1800, 1820, 1842, 1861, 1893, 1916, 1945, 1966, 1992, 2048, 2061, 2085, 2116, 2160, 2182, 2205, 2222, 2280, 2309, 2356, 2383, 2463, 2480, 2506, 2523, 2574, 2611, 2721, 2755, 2930, 2960, 2998, 3042, 3080, 3105, 3125, 3146, 3172, 3217, 3280, 3377, 3709, 3729, 3764, 3872, 3961, 4209, 4259, 4284, 4343], 'Scholar,': [446, 462, 548, 566, 665, 844, 869, 887, 903, 940, 969, 992, 1279, 1406, 1510, 1533, 1683, 1708, 1739, 1783, 1801, 1821, 1843, 1862, 1894, 1917, 1946, 1967, 2049, 2062, 2086, 2161, 2183, 2206, 2357, 2464, 2481, 2507, 3710], '2Mangelsdorf': [447], 'D.J.': [448], 'Evans': [449, 831, 876, 1396, 1698, 1879, 2034, 3160], 'R.M.': [450, 832, 877, 1397, 1699, 1880, 2035, 3161], 'Cell.': [451, 469, 652, 833, 909, 1670, 1853, 1881, 2036, 2073, 2455, 2472, 2494, 2603, 3162, 3209], '1995;': [452, 470, 541, 834, 933, 1399, 1430, 1776, 3163], '83:': [453, 471], '841-850Abstract': [454], 'Full': [455, 473, 656, 658, 837, 1294, 1296, 1674, 1676, 1885, 1887, 1984, 1986, 2040, 2042, 2077, 2079, 2498, 2500, 3166, 3756, 3758, 3864, 3866, 3953, 3955, 4251, 4253], 'Text': [456, 474, 657, 659, 838, 1295, 1297, 1675, 1677, 1886, 1888, 1985, 1987, 2041, 2043, 2078, 2080, 2499, 2501, 3167, 3757, 3759, 3865, 3867, 3954, 3956, 4252, 4254], 'PDF': [457, 475, 660, 839, 1298, 1678, 1889, 1988, 2044, 2081, 2502, 3168, 3760, 3868, 3957, 4255], '(2861)': [460], '3Beato': [463], 'M.': [464, 570, 850, 925, 960, 1066, 1424, 1501, 1622, 1697, 1724, 1827, 2167, 2466, 2599], 'Herrlich': [465], 'P.': [466, 539, 669, 927, 1002, 1187, 1543, 1809, 1831, 2171, 2515, 2703, 2942, 3062], 'Schutz': [467], 'G.': [468, 550, 1062, 1931, 2090, 2266, 3743, 3851, 3940], '851-857Abstract': [472], '(1642)': [478], 'Scholar).': [480, 688, 916, 1381, 1631, 1993, 2117, 2223, 2310, 2384, 2575, 2612, 2756, 2931, 2961, 2999, 3043, 3173, 3218, 3378, 3730, 3765, 3873, 3962, 4210, 4285, 4344], 'The': [481, 1454, 1994, 2674, 2757, 3044, 3427, 3821, 3839, 3874, 3923, 4107, 4136, 4164, 4286], 'capability': [482, 818], 'many': [484, 770, 2130], 'family': [485, 1760], 'members': [486, 1755], 'bind': [488, 1391, 2538], 'structurally': [489], 'diverse': [490, 753], 'hydrophobic': [491], 'ligands': [492, 586, 776, 822, 1390, 1575, 1586, 2535], 'crucial': [495], 'regulatory': [496, 2647], 'transmission': [500], 'extracellular': [502], 'signals': [503], 'into': [504, 743, 2723, 2780, 2786, 2808, 2834, 2861, 2881, 2898, 2973, 3010, 3190, 3230], 'intracellular': [505], 'responses.': [507], 'However,': [508, 1169], 'alternative': [509], 'ligand-independent': [510], 'regulation': [511], 'mechanisms': [512, 2589], 'have': [513, 777, 801, 1171, 1245, 1635, 2617, 2733, 3047, 3738], '(4Kato': [516], 'S.': [517, 525, 529, 673, 983, 1068, 1076, 1098, 1132, 1191, 1283, 1285, 1524, 1716, 1730, 1904, 1958, 2193, 2212, 2707, 2946, 3066], 'Endoh': [518], 'H.': [519, 527, 535, 929, 1006, 1547, 1695, 1718, 1811, 1833, 1845, 1948, 2173, 2361, 2371, 3201, 4321, 4331], 'Masuhiro': [520], 'Y.': [521, 531, 631, 973, 1422, 1514, 1649, 1878, 1902, 2033, 2072, 2191, 2451, 2485, 4240], 'Kitamoto': [522], 'T.': [523, 635, 950, 1412, 1491, 1612, 1653, 1691, 2053, 2363, 2367, 2369, 2373, 2740, 2915, 2983, 3027, 3265, 3362, 3714, 4194, 4323, 4327, 4329, 4333], 'Uchiyama': [524], 'Sasaki': [526], 'Masushige': [528], 'Gotoh': [530], 'Nishida': [532], 'Kawashima': [534], 'Metzger': [536], 'D.': [537, 556, 931, 1004, 1545, 1685, 1870, 2025], 'Chambon': [538, 926, 1001, 1542, 1808, 1830, 2170], 'Science.': [540, 680, 1198, 1775, 1938, 2273, 2302, 2349, 2567, 2714, 2953, 3073, 4277], '270:': [542, 1777], '1491-1494Crossref': [543], '(1731)': [546], '5Bunone': [549], 'Briand': [551], 'P.A.': [552, 2447], 'Miksicek': [553], 'R.J.': [554, 1866, 2021], 'Picard': [555], 'EMBO': [557, 575, 1792, 1812, 1834, 2152, 2174, 3117], 'J.': [558, 576, 637, 830, 848, 852, 891, 1096, 1130, 1288, 1414, 1655, 1714, 1793, 1813, 1835, 1896, 1900, 1921, 1978, 2153, 2175, 2185, 2189, 2256, 2453, 2744, 2919, 2987, 3031, 3118, 3159, 3269, 3366, 3718, 3750, 3858, 3947, 4198, 4245], '15:': [560, 1815], '2174-2183Crossref': [561], '(858)': [564], '6White': [567], 'R.': [568, 639, 846, 1418, 1657, 1712, 1722, 2468], 'Sjoberg': [569], 'Kalkhoven': [571, 2209], 'Parker': [573, 1286, 1790, 2150, 2213, 3115], 'M.G.': [574, 651, 856, 1287, 1369, 1428, 1669, 1791, 1908, 2151, 2197, 2214, 3116], '1997;': [577, 681, 880, 896, 911, 962, 1102, 1136, 1199, 1272, 1291, 1374, 1503, 1624, 1855, 1882, 1910, 1939, 1960, 1981, 2037, 2110, 2199, 2216, 2274, 2377, 2474, 2517, 2605, 2715, 2954, 3074, 3099, 3140, 3211, 3703, 3753, 3861, 3950, 4337], '16:': [578], '1427-1435Crossref': [579], '(107)': [582], 'Scholar),': [584, 1437, 3126, 3147, 3281, 4260], 'not': [588, 614, 778, 1308, 4354], 'exist': [589, 1047], 'all': [591], 'usually': [595], 'modulate': [596], 'their': [599, 1177, 1217, 1225], 'genes': [601], 'cognate': [605], 'promoter': [606, 3396], 'response': [607, 1152], 'elements.': [608], 'Moreover,': [609], 'cross-talk': [610], 'mechanisms,': [611], 'do': [613], 'require': [615], 'binding,': [617], 'allow': [619], 'influence': [623, 815], 'other': [627, 1256], '(7Kamei': [630, 1648], 'Xu': [632, 1650], 'L.': [633, 954, 1352, 1495, 1616, 1651, 1874, 2029, 2742, 2917, 2985, 3029, 3267, 3364, 3716, 4196], 'Heinzel': [634, 1411, 1652], 'Torchia': [636, 1413, 1654], 'Kurokawa': [638, 1417, 1656, 1721], 'Gloss': [640, 853, 1415, 1658], 'B.': [641, 854, 1090, 1124, 1416, 1659, 1710, 1720], 'Lin': [642, 1660, 1865, 2020, 4239], 'S.-C.': [643, 1661], 'Heyman': [644, 857, 1662], 'R.A.': [645, 858, 1663], 'Rose': [646, 1366, 1664, 1897, 2186], 'D.W.': [647, 1367, 1665, 1898, 2187], 'Glass': [648, 859, 1425, 1666, 1905, 2194], 'C.K.': [649, 860, 1365, 1426, 1667, 1906, 2195], 'Rosenfeld': [650, 855, 1368, 1427, 1668, 1907, 2196], '85:': [654, 1672], '403-414Abstract': [655, 1673], '(1931)': [663, 1681], '8Paech': [666, 3059], 'K.': [667, 828, 1092, 1126, 1185, 1263, 1265, 1847, 2701, 2940, 3060, 3090, 3092, 3131, 3133, 3157, 3203, 3694, 3696], 'Webb': [668, 1186, 2702, 2941, 3061], 'Kuiper': [670, 1188, 1266, 2704, 2943, 3063, 3093, 3134, 3697], 'G.G.': [671, 1088, 1122, 1189, 1267, 2705, 2944, 3064, 3094, 3135, 3698], 'Nilsson': [672, 1067, 1097, 1131, 1190, 2706, 2945, 3065], 'Kushner': [676, 1194, 2710, 2949, 3069], 'P.J.': [677, 1195, 1950, 2711, 2950, 3070], 'Scanlan': [678, 1196, 2712, 2951, 3071], 'T.S.': [679, 1197, 2713, 2952, 3072], '277:': [682, 1200, 1940, 2275, 2716, 2955, 3075], '1508-1510Crossref': [683, 1201, 2717, 2956, 3076], '(2083)': [686, 1204, 2720, 2959, 3079], 'are': [691, 785, 1041, 1590, 4371], 'modular': [692], 'containing': [695, 3393, 3667, 4052], 'variable': [697, 718], 'N-terminal': [698, 1474], 'often': [700], 'exhibiting': [701], 'constitutive': [703], '(AF-1),1': [707], 'highly': [709, 1461, 4290], 'zinc': [711], 'finger': [712], 'type': [713, 2426], '(DBD),': [716], 'linker': [719], 'region': [720], '(hinge),': [721], 'multifunctional': [724], 'C-terminal': [725, 1466], 'responsible': [727], 'ligand': [729, 1118, 1438], '(LBD),': [731], 'dimerization,': [732], '(AF-2).': [737], 'can': [740, 2537], 'be': [741, 1164, 1209, 1578, 1639], 'subdivided': [742], 'mainly': [747], 'form': [748, 788, 1249], 'homodimers': [749], 'large': [752], 'subfamily': [754], 'hormone,': [762], 'retinoids,': [763], 'vitamin': [765], 'D': [766], 'well': [768, 1472, 2283], 'natural': [775], 'identified.': [780], 'Whereas': [781], 'monomeric': [786], 'or': [787, 2785, 3340, 3346, 3390, 3416, 3422, 3445, 3595, 3604, 3622, 3635, 3637, 3669, 4082], 'homodimers,': [789], 'majority': [791], 'heterodimerizes': [792], '(RXR).': [798], 'These': [799, 1220], 'heterodimers': [800, 1253], 'recognized': [803], 'very': [807], 'dynamic': [808], 'both': [813, 2010, 2440, 3320], 'subunits': [814], "other's": [817], 'interact': [820, 4175], 'cofactors': [824, 1327, 2132], '(9Forman': [825, 3154], 'B.M.': [826, 3155], 'Umesono': [827, 3156], 'Chen': [829, 1951, 3158], '81:': [835, 3164], '541-550Abstract': [836, 3165], '(575)': [842, 3171], '10Kurokawa': [845], 'DiRenzo': [847], 'Boehm': [849], 'Sugarman': [851], 'Nature.': [861, 932, 961, 1398, 1429, 1502, 1623, 1700, 1909, 2054, 2109, 2198, 2215, 2516], '1994;': [862], '371:': [863], '528-531Crossref': [864], '(395)': [867], '11Schulman': [870], 'I.G.': [871, 1693], 'Li': [872], 'C.': [873, 1807, 2449], 'Schwabe': [874], 'J.W.': [875], 'Genes': [878, 894, 1744], 'Dev.': [879, 895, 1745], '11:': [881, 897, 1273, 3100, 3141, 3704], '299-308Crossref': [882], '(115)': [885], '12Zamir': [888], 'I.': [889], 'Zhang': [890], 'Lazar': [892], 'M.A.': [893], '835-846Crossref': [898], '(204)': [901], '13Wiebel': [904], 'F.F.': [905], 'Biol.': [910, 1009, 1289, 1373, 1550, 1854, 1979, 2456, 2473, 2604, 3210, 3751, 3859, 3948, 4246], '17:': [912, 1795, 1837, 1856, 2155, 2177, 2475, 2606, 3120, 3212], '3977-3986Crossref': [913], 'Functional': [917], 'structural': [919, 1443, 2122], 'analysis': [920, 2670], '(Refs.': [921, 1060, 1481, 2445], '14Bourguet': [922], 'W.': [923, 996, 1537, 2344, 2562, 2597, 4272], 'Ruff': [924], 'Gronemeyer': [928, 1005, 1546, 1810, 1832, 2172], 'Moras': [930, 1003, 1544], '375:': [934], '377-382Crossref': [935], '(1071)': [938], '15Brzozowski': [941, 1482], 'A.M.': [942, 1410, 1483, 1604], 'Pike': [943, 1484, 1605], 'A.C.': [944, 1485, 1606], 'Dauter': [945, 1486, 1607], 'Z.': [946, 1487, 1608], 'Hubbard': [947, 1488, 1609], 'R.E.': [948, 1489, 1610], 'Bonn': [949, 1490, 1611], 'Engström': [951, 1492, 1613], 'O.': [952, 1493, 1614], 'Ohman': [953, 1494, 1615], 'Greene': [955, 1496, 1617], 'G.L.': [956, 1497, 1618], 'Carlquist': [959, 1500, 1621], '389:': [963, 1504, 1625, 2111], '753-758Crossref': [964, 1505, 1626], '(3002)': [967, 1508, 1629], '16Tanenbaum': [970, 1511], 'D.M.': [971, 1512, 1789, 2149, 2208, 2513, 3114], 'Wang': [972, 1513], 'Williams': [974, 1515], 'S.P.': [975, 1516], 'Sigler': [976, 1517], 'P.B.': [977, 1518], 'Proc.': [978, 1071, 1519, 1725, 1953], 'Natl.': [979, 1072, 1520, 1726, 1954], 'Acad.': [980, 1073, 1521, 1727, 1955], 'Sci.': [981, 1074, 1522, 1728, 1956], 'U.': [982, 1075, 1523, 1729, 1957], 'A.': [984, 1077, 1420, 1525, 1731, 1872, 1959, 1969, 2027, 3747, 3855, 3944], '1998;': [985, 1526, 1746, 1794, 1836, 2154, 2176, 2303, 2457, 2495, 2749, 2924, 2992, 3036, 3119, 3274, 3371, 3723, 4203], '95:': [986, 1527], '5998-6003Crossref': [987, 1528], '(606)': [990, 1531], '17Wurtz': [993, 1534], 'J.M.': [994, 1535, 1935, 2270, 2291], 'Bourguet': [995, 1536], 'Renaud': [997, 1538], 'J.P.': [998, 1539], 'Vivat': [999, 1540, 1828, 2168], 'V.': [1000, 1541, 1829, 2068, 2169], 'Nat.': [1007, 1548], 'Struct.': [1008, 1549], '3:': [1011, 1552], '87-94Crossref': [1012, 1553], '(691)': [1015, 1556], 'Scholar': [1017, 1085, 1109, 1362, 1558, 2524, 3081], 'references': [1019, 1111, 1560, 2526, 3083], 'therein)': [1020], 'common': [1023], 'dimerization': [1024, 4184], 'surface': [1025, 1458], 'within': [1026, 1445, 2414], 'LBDs': [1028], 'primarily': [1030], 'formed': [1032], 'helices': [1034, 1475], '10/11': [1035], '(dimerization': [1036], 'helix).': [1037], 'Estrogen': [1038], '(ERs)': [1040], 'unique': [1042, 1310], 'they': [1046], 'two': [1049, 1054, 1460, 3996, 4037], 'different': [1050, 1239, 1595, 3332], 'paralogues': [1051], '(encoded': [1052], 'separate': [1055], 'genes),': [1056], 'ERβ': [1059, 1236, 2971, 3057, 3636], '18Kuiper': [1061], 'Enmark': [1063, 1093, 1127, 3744, 3852, 3941], 'Pelto-Huikko': [1065], '93:': [1079, 1733, 2496], '5925-5930Crossref': [1080], '(4268)': [1083], '19Kuiper': [1087], 'Carlsson': [1089, 1123], 'Grandien': [1091, 1125, 1264, 3091, 3132, 3695], 'Haggblad': [1095, 1129], 'Endocrinology.': [1101, 1135], '138:': [1103, 1137], '863-870Crossref': [1104, 1138], '(3678)': [1107, 1141], 'therein).': [1112, 1561, 2527], 'Both': [1113, 3536], 'display': [1115], 'quite': [1116], 'similar': [1117, 2801], 'characteristics': [1120], '(19Kuiper': [1121], 'Scholar)': [1143, 1206, 1303, 1753, 2281, 2722, 3106], 'comparable': [1145], 'agonist-dependent': [1146], 'activities': [1148], 'on': [1149, 1260, 2386, 3327, 4049, 4140, 4159], '"classical"': [1150], 'elements': [1153], '(EREs),': [1154], 'consistent': [1155], 'conservation': [1158, 1215, 2123], 'LBD/AF-2': [1160, 1447, 2319, 2681], 'regions': [1161, 4352], 'implicated': [1162], 'critical': [1165], 'functions.': [1168], 'differences': [1170], 'reported': [1173], 'regard': [1175], 'antagonist-dependent': [1178], 'properties': [1180], 'at': [1181, 3434, 3788, 3798, 3969, 3991, 4011, 4032, 4120, 4133], 'AP1': [1182], 'sites': [1183, 2789, 2863, 2884, 2976, 3013, 3233], '(8Paech': [1184, 2700, 2939], 'might': [1208], 'related': [1210], 'lack': [1213], 'N': [1218], 'termini.': [1219], 'functional': [1221], 'differences,': [1222], 'together': [1223, 3628], 'distinct': [1226], 'expression': [1227, 2237, 3052, 3643], 'pattern': [1228], 'strongly': [1231], 'play': [1238], 'roles': [1240, 2438], 'gene': [1242, 2236, 2244], 'regulation.': [1243], 'They': [1244], 'demonstrated': [1247, 1637], 'stable': [1250], 'homo-': [1251], 'each': [1255], 'solution': [1258, 3978, 4020], '(20Pettersson': [1262, 3089, 3130, 3693], '1486-1496Crossref': [1274, 3101, 3142, 3705], '(559)': [1277, 3104, 3145, 3708], '21Cowley': [1280], 'S.M.': [1281], 'Hoare': [1282, 2211], 'Mosselman': [1284], 'Chem.': [1290, 1980, 3752, 3860, 3949, 4247], '272:': [1292, 1982, 2351, 2569, 3754, 3862, 3951, 4279], '19858-19862Abstract': [1293], '(611)': [1301], 'indicating': [1304], 'heterodimerization': [1306, 2560], 'feature': [1311], 'forming': [1315], 'RXR': [1316, 2558, 4186], 'heterodimers.': [1317], 'concert': [1324], 'basal': [1329, 2012], 'factors,': [1331], 'chromatin-modifying': [1332], 'complexes,': [1333], 'corepressors,': [1334], 'review': [1338], '22Horwitz': [1341], 'K.B.': [1342], 'Jackson': [1343], 'T.A.': [1344], 'Rain': [1345], 'D.L.': [1346, 2487], 'Richer': [1347], 'J.K.': [1348, 4244], 'Takimoto': [1349], 'G.S.': [1350], 'Tung': [1351], '1167-1177Crossref': [1357], '(838)': [1360], '23Glass': [1364], 'Curr.': [1370], 'Opin.': [1371], 'Cell': [1372, 3684], '9:': [1375], '222-232Crossref': [1376], '(604)': [1379], 'absence': [1387, 3339, 3414], 'agonistic': [1389, 1574], 'corepressors': [1393], '(24Chen': [1394], 'J.D.': [1395, 1952], '377:': [1400, 1431], '454-457Crossref': [1401], '(1727)': [1404], '25Hörlein': [1407], 'A.J.': [1408, 2051], 'Näär': [1409], 'Ryan': [1419], 'Kamei': [1421, 1901, 2190], 'Söderström': [1423], '397-404Crossref': [1432], '(1724)': [1435], 'associated': [1441], 'rearrangements': [1444], 'domain,': [1448], 'permitting': [1449], 'recruitment': [1451], 'coactivators.': [1453], 'predicted': [1455, 4306], 'includes': [1459], 'regions,': [1463], 'namely': [1464], 'helix': [1467, 1569], '12': [1468, 1570, 3655], '(AF-2': [1469], 'core)': [1470], '3–5': [1476], '"signature': [1479], 'region"': [1480], 'In': [1562, 2118, 2311, 2613], 'particular,': [1563], 'precise': [1565], 'positional': [1566], 'rearrangement': [1567], 'upon': [1571], 'seems': [1576], 'prerequisite': [1580], 'binding.': [1583], 'Conversely,': [1584], 'antagonistic': [1585], 'anti-estrogens': [1589], 'thought': [1591], 'induce': [1593], 'conformation': [1596], 'prevents': [1598], 'association': [1600], '(15Brzozowski': [1603], 'Common': [1632], 'coactivators,': [1633], 'relevant': [1640], 'also': [1641], 'ERs,': [1643], 'include,': [1644], 'example,': [1646, 2234], 'p300/CBP': [1647], '26Chakravarti': [1684], 'Lamorte': [1686], 'V.J.': [1687], 'Nelson': [1688], 'M.C.': [1689], 'Nakajima': [1690], 'Schulman': [1692], 'Juguilon': [1694], 'Montminy': [1696], '383:': [1702], '99-103Crossref': [1703], '(852)': [1706], '27Hanstein': [1709], 'Eckner': [1711], 'Direnzo': [1713], 'Halachmi': [1715], 'Liu': [1717], 'Searcy': [1719], 'Brown': [1723], '11540-11545Crossref': [1734], '(344)': [1737], '28Kraus': [1740], 'W.L.': [1741], 'Kadonaga': [1742], 'J.T.': [1743], '12:': [1747, 2750, 2925, 2993, 3037, 3275, 3372, 3724, 4204], '331-342Crossref': [1748], '(290)': [1751, 2462], 'p160/SRC-1': [1758, 2230], '(e.g.': [1761], 'SRC-1,': [1762], 'TIF2,': [1763], 'AIB1;': [1764], '29Oñate': [1767], 'S.A.': [1768, 2102], 'Tsai': [1769, 1771, 2103, 2105, 2296, 2298], 'S.Y.': [1770, 2104, 2297], 'M.J.': [1772, 1805, 1825, 1849, 2106, 2165, 2299, 3205], "O'Malley": [1773], 'B.W.': [1774, 2108, 2301], '1354-1357Crossref': [1778], '(2075)': [1781], '30Kalkhofen': [1784], 'Valentine': [1786, 2146, 3111], 'J.E.': [1787, 2147, 3112], 'Heery': [1788, 2148, 3113], '232-243Crossref': [1796, 2156, 3121], '(276)': [1799, 2159, 3124], '31Voegel': [1802], 'J.J.': [1803, 1823, 2163], 'Heine': [1804, 1824, 2164], 'Zechel': [1806], '3667-3675Crossref': [1816], '(957)': [1819], '32Voegel': [1822, 2162], 'Tini': [1826, 2166], '507-519Crossref': [1838, 2178], '(433)': [1841, 2181], '33Hong': [1844], 'Kohli': [1846, 3202], 'Garabedian': [1848, 3204], 'Stallcup': [1850, 3206], 'M.R.': [1851, 3207], '2735-2744Crossref': [1857, 3213], '(498)': [1860, 3216], '34Chen': [1863], 'H.W.': [1864, 2019], 'Schiltz': [1867, 2022, 2065], 'R.L.': [1868, 1923, 2023, 2066, 2258], 'Chakravarti': [1869, 2024], 'Nash': [1871, 2026], 'Nagy': [1873, 2028], 'Privalsky': [1875, 2030], 'M.L.': [1876, 2031], 'Nakatani': [1877, 2032, 2071], '90:': [1883, 2038], '569-580Abstract': [1884, 2039], '(1278)': [1892, 2047], '35Torchia': [1895, 2184], 'Inostroza': [1899, 2188], 'Westin': [1903, 2192], '387:': [1911, 2200, 2217], '677-684Crossref': [1912, 2201], '(1111)': [1915, 2204], '36Anzick': [1918], 'S.L.': [1919, 2254], 'Kononen': [1920, 2255], 'Walker': [1922, 2257], 'Azorsa': [1924, 2259], 'D.O.': [1925, 2260], 'Tanner': [1926, 2261], 'M.M.': [1927, 2092, 2262], 'Guan': [1928, 2263], 'X.Y.': [1929, 2264], 'Sauter': [1930, 2265], 'Kallioniemi': [1932, 2267], 'O.P.': [1933, 2268], 'Trent': [1934, 2269], 'Meltzer': [1936, 2271], 'P.S.': [1937, 2272], '965-968Crossref': [1941, 2276], '(1446)': [1944, 2279], '37Li': [1947], 'Gomes': [1949], '94:': [1961], '8479-8484Crossref': [1962], '(507)': [1965], '38Takeshita': [1968], 'Cardona': [1970], 'G.R.': [1971], 'Koibuchi': [1972], 'N.': [1973, 2359, 2365, 4319, 4325], 'Suen': [1974], 'C.-S.': [1975], 'Chin': [1976], 'W.W.': [1977], '27629-27634Abstract': [1983], '(327)': [1991], 'detection': [1995], 'intrinsic': [1997, 2584], 'histone-acetyltransferase': [2001], 'functionally': [2006], 'connects': [2007], 'them': [2008], 'machinery': [2014], 'chromatin': [2017], '(34Chen': [2018], '39Bannister': [2050], 'Kouzarides': [2052], '384:': [2056], '641-643Crossref': [2057], '(1548)': [2060], '40Ogryzko': [2063], 'V.V.': [2064], 'Russanova': [2067], 'Howard': [2069], 'B.H.': [2070], '87:': [2075], '953-959Abstract': [2076], '(2445)': [2084], '41Spencer': [2087], 'T.E.': [2088], 'Jenster': [2089], 'Burcin': [2091], 'Allis': [2093], 'C.D.': [2094], 'Zhou': [2095], 'J.X.': [2096], 'Mizzen': [2097], 'C.A.': [2098], 'McKenna': [2099], 'N.J.': [2100], 'Onate': [2101], 'O′Malley': [2107, 2300], '194-198Crossref': [2112], '(1076)': [2115], 'agreement': [2119], 'interaction': [2128, 2137], 'surface,': [2129], 'contain': [2133], 'LXXLL': [2136], 'motifs,': [2138], 'referred': [2139], 'NR': [2142], 'box': [2143], '(30Kalkhofen': [2144, 3109], '42Heery': [2207], '733-736Crossref': [2218], '(1798)': [2221], 'Biological': [2224], 'evidence': [2225, 2628], 'involvement': [2228], 'in,': [2232], 'comes': [2238], 'from': [2239, 2285, 2825, 3183, 3909], 'discovery': [2241], 'AIB1': [2243], 'amplification': [2245, 3831, 3843], 'ER-positive': [2247], 'ovarian': [2250], 'cells': [2252, 3336, 3476, 3508, 3538, 3541, 3571, 3580, 3583, 3600, 3681, 4074, 4108], '(36Anzick': [2253], 'recent': [2286], 'SRC-1': [2287], 'knock-out': [2288], '(43Xu': [2290], 'Qiu': [2292], 'Y.H.': [2293], 'Demayo': [2294], 'F.J.': [2295], '279:': [2304], '1922-1925Crossref': [2305], '(600)': [2308], 'searching': [2312], 'interacting': [2316, 3247], 'isolated': [2330, 3239], 'obviously': [2332], 'receptor-type': [2336, 4364], 'DBD': [2337, 3302], 'LBD': [2342, 4178], '(44Seol': [2343, 2561, 4271], 'Choi': [2345, 2563, 4273], 'H.S.': [2346, 2564, 4274], 'Moore': [2347, 2565, 2600, 4275], 'D.D.': [2348, 2566, 2601, 4276], '1336-1339Crossref': [2352, 2570, 4280], '(451)': [2355, 2573, 4283], '45Masuda': [2358], 'Yasumo': [2360, 4320], 'Tamura': [2362, 4322], 'Hashiguchi': [2364, 4324], 'Furusawa': [2366, 4326], 'Tsukamoto': [2368, 4328], 'Sadano': [2370, 4330], 'Osumi': [2372, 4332], 'Biochim.': [2374, 4334], 'Biophys.': [2375, 4335], 'Acta.': [2376, 4336], '1350:': [2378, 4338], '27-32Crossref': [2379, 4339], '(48)': [2382, 4342], 'Based': [2385], 'its': [2387, 2391, 2593, 4294], 'small': [2388], 'size': [2389], 'ability': [2392], 'interact,': [2394], 'like': [2395], 'RXR,': [2396], 'this': [2401, 2614], 'designated': [2406], 'partner).': [2410], 'Its': [2411], 'closest': [2412], 'relative': [2413], 'DAX-1,': [2421], 'DBD,': [2428], 'SF-1,': [2434], 'plays': [2436], 'important': [2437], 'adrenal': [2441], 'gonadal': [2443], '46Crawford': [2446], 'Dorn': [2448], 'Sadovsky': [2450], 'Milbrandt': [2452], '18:': [2458], '2949-2956Crossref': [2459], '47Ito': [2465], 'Yu': [2467], 'Jameson': [2469], 'J.L.': [2470], '1476-1483Crossref': [2476], '(403)': [2479], '48Nachtigal': [2482], 'M.W.': [2483], 'Hirokawa': [2484], 'Enyeartvanhouten': [2486], 'Flanagan': [2488], 'J.N.': [2489], 'Hammer': [2490], 'G.D.': [2491], 'Ingraham': [2492], 'H.A.': [2493], '445-454Abstract': [2497], '(503)': [2505], '49Zazopoulos': [2508], 'Lalli': [2510], 'Stocco': [2512], 'Sassone-Corsi': [2514], '390:': [2518], '311-315Crossref': [2519], '(370)': [2522], 'unknown': [2531], 'whether': [2532], 'DNA,': [2539], 'suggested': [2543], 'pathways': [2554], 'Furthermore,': [2576], 'shown': [2581], 'exert': [2583], 'repressor': [2585], 'activity,': [2586], 'active': [2587], 'repression': [2588], 'contribute': [2591], 'inhibitory': [2594], 'effect': [2595], '(50Seol': [2596], 'Chung': [2598], '7126-7131Crossref': [2607], '(119)': [2610], 'report,': [2615], 'we': [2616, 2644], 'SHP.': [2625, 3838], 'provide': [2627], 'existence': [2631], 'activation,': [2642], 'opposing': [2646], 'functions': [2648], 'signaling.': [2656], '—All': [2657], 'plasmids': [2658, 3046, 3303, 3389], 'were': [2659, 2688, 2770, 2847, 3314, 3323, 3354, 3402, 3429, 3466, 3477, 3509, 3542, 3572, 3614, 3645, 3682, 3686, 3828, 3846, 3899, 3927, 4047, 4075, 4109, 4138, 4157], 'generated': [2660, 3382, 3449], 'using': [2661, 2850, 3331, 3397, 3577, 3597, 3616, 3915, 4089], 'standard': [2662], 'cloning': [2663, 2807, 2821, 2876, 3006, 3179, 3224], 'procedures': [2664], 'verified': [2666], 'restriction': [2668], 'enzyme': [2669], 'sequencing.': [2673], 'Gal4': [2675, 2758, 2804, 3150, 3301], 'fusion': [2678, 3410], 'constructs': [2679, 2761, 3087, 3576], 'Gal-ERα': [2680], '(aa': [2682, 2686, 2797, 2870, 2889, 2906, 2933, 2963, 3001, 3018, 3128, 3228, 3252], '249–595)': [2683, 2798], 'Gal-ERβLBD/AF-2': [2685], '168–485)': [2687], 'constructed': [2689, 2771, 2848, 2892, 3221], 'inserting': [2691, 2773, 2894], 'PCR-generated': [2692, 2774, 2896], 'fragments': [2693, 2775], 'corresponding': [2696, 3008], 'human': [2697, 2970, 4297], 'ER': [2698, 3085], 'cDNAs': [2699], 'BamHI': [2725, 2810], 'site': [2726, 2783, 2811, 2836, 2901, 3193], 'AS2–1': [2728], '(CLONTECH).': [2729, 2795, 3236], 'Gal-PPARαLBD': [2730], 'Gal-RXRβLBD': [2732], 'described': [2735, 2910, 2937, 3022, 3049, 3198, 3255, 3358, 3692, 3740, 3848, 3937], 'previously': [2736, 2911, 2938, 3023, 3199, 3256, 3741, 3849, 3936, 4232], '(51Treuter': [2737, 2912, 2980, 3024, 3262, 3359], 'Albrektsen': [2739, 2914, 2982, 3026, 3264, 3361, 3713, 4193], 'Johansson': [2741, 2916, 2984, 3028, 3266, 3363, 3715, 4195], 'Leers': [2743, 2918, 2986, 3030, 3268, 3365, 3717, 4197], '864-881Crossref': [2751, 2926, 2994, 3038, 3276, 3373, 3725, 4205], '(0)': [2754, 2929, 2997, 3041, 3279, 3376, 3728, 4208], 'GAD-SHP': [2762], 'WT,': [2763], 'D1,': [2764], 'D2': [2766, 2846], '(see': [2767, 3188], 'Fig.': [2768], '1)': [2769], 'cDNA': [2779, 2972, 3009, 3186, 3287, 3736, 3775, 3913, 4218], 'EcoRI': [2782, 3181, 3192], '(WT)': [2784], 'EcoRI/XhoI': [2788, 2883], '(D1': [2790], 'D2)': [2792], 'GADGH': [2794], 'GST-ERα': [2796], 'was': [2799, 2818, 2872, 2891, 2935, 2965, 3003, 3176, 3197, 3220, 3238, 3290, 3304, 3448, 3458, 3659, 3673, 3776, 3878, 3967, 4009, 4101, 4168], 'made': [2800, 2819, 2873, 2966, 3004, 3177], 'construct': [2805, 3152], 'pGEX-2TK': [2813], '(Amersham': [2814, 2839, 2866], 'Pharmacia': [2815, 2840, 2867], 'Biotech).': [2816, 2841, 2868], 'GST-SHPWT': [2817], 'SalI': [2823], 'fragment': [2824, 2854, 2880, 2897, 3836], 'original': [2827, 3911], 'yeast': [2828, 2858, 3242, 3294, 3335, 4165], 'two-hybrid': [2829, 3243, 3295, 4166], 'library': [2830, 3185, 3288, 4219], 'clone': [2831, 3187, 4264], '(GAD10-SHP,': [2832], 'CLONTECH)': [2833], 'theXhoI': [2835], 'pGEX4T-3': [2838], 'GST-SHP': [2842, 2845], 'D1': [2843], 'same': [2852, 3917], 'PCR': [2853, 2875, 3223, 3391, 3768, 3817, 3875, 3897, 3925], 'vectors': [2859, 3053, 3644], 'inserted': [2860], 'theEcoRI/SalI': [2862], 'pGEX4T-1': [2865], 'GST-TIF2': [2869, 3456], '594–766)': [2871], 'TIF2': [2879, 3446], 'pGEX4T-1.': [2886], 'His-SHP': [2887], 'WT': [2888], '1–260)': [2890, 3229], 'NdeI/SalI': [2900], 'pET15b': [2903], '(Novagen).': [2904], 'His-RIP140': [2905], '747–1158)': [2907], 'pT7ERα': [2932], '1–595)': [2934], 'pT3ERβ': [2962], '1–485)': [2964], 'recloning': [2968], 'XhoI/NotI': [2975], 'pBKCMV': [2978], 'HA': [2979], 'T3-TIF2': [3000], '1–1465)': [3002], 'EcoRI/Xho': [3012], 'pBK-CMV': [3015], '(Stratagene).': [3016], 'T3-RIP140': [3017], '1–1158)': [3019], 'following': [3045], 'previously:': [3050], 'pSG5-based': [3051], '(Ref.': [3058], 'therein),': [3084], 'reporter': [3086, 3151, 3621], '2xERE-tk-luc': [3088], '3xERE-TATA-luc': [3108], 'pCMXGaL4ERαLBD': [3127], '247–599)': [3129], 'UAS-tk-luc': [3153], 'pSG5': [3174], 'rSHPWT': [3175], 'insert': [3182], 'above)': [3189], 'pSG5(Stratagene).': [3195], 'pSG5-TIF2/GRIP1': [3196], '(33Hong': [3200], 'pSHP-GFP': [3219], 'full-length': [3226, 4263], 'EcoRI/BamHI': [3232], 'pEGFP-N3': [3235], 'screening': [3244], 'PPARαLBD/AF-2': [3251], '166–468)': [3253], 'isolation': [3259, 3733, 4223], 'hRIP140': [3261], 'except': [3282], 'liver': [3286, 4217], '(CLONTECH)': [3289, 3979], 'used.': [3291], 'For': [3292, 3437, 3766], 'analysis,': [3296], 'HF7c': [3297], '(MATα)': [3298], 'transformed': [3299, 3308], 'mated': [3305], 'Y187(MATα)': [3307], 'GAD': [3310], 'plasmids.': [3311, 3321], 'Diploid': [3312], 'strains': [3313], 'selected': [3315], 'presence': [3318, 3341, 3417], 'Interactions': [3322], 'monitored': [3324], 'growth': [3326], 'selective': [3328], '−His': [3329], 'plates': [3330, 3546, 4051], 'dilutions': [3333], 'μm': [3344, 3348, 3420, 3424], '17β-estradiol': [3345, 3421, 3672], '4-OH': [3349, 3425], 'tamoxifen,': [3350], 'respectively.': [3351], 'Interaction': [3352], 'performed': [3355, 3615, 3879, 3968, 4010], 'essentially': [3356], 'Briefly,': [3379], '35S-labeled': [3380], 'proteins,': [3381], 'vitro': [3385], 'transcription/translation': [3386], 'either': [3388, 3441, 3633], 'products': [3392, 3898, 3926], '5′-T3': [3395], 'TNT': [3399], 'kit': [3400], '(Promega),': [3401], 'incubated': [3403, 3430], 'approximately': [3405], 'μg': [3407, 3618, 3624, 3631, 4079, 4085], 'GST': [3409], '(Me2SO)': [3415], 'tamoxifen.': [3426], '2–3': [3432], 'h': [3433, 3676, 3974, 4016, 4104], '4': [3435], '°C.': [3436, 3886], 'assay,': [3440], 'purified': [3442, 3455], 'His-SHP,': [3443], 'His-RIP140,': [3444], '(which': [3447], 'thrombin': [3451], 'cleavage': [3452], 'protein)': [3457], 'added': [3459, 3646, 3777], 'reaction.': [3463], 'Protein': [3464], 'analyzed': [3467, 3687], 'SDS-polyacrylamide': [3469], 'gel': [3470, 3889], 'electrophoresis': [3471, 3890], 'followed': [3472, 3794, 3980, 4021, 4147], 'autoradiography.': [3474], '293': [3475, 3537, 3582], 'maintained': [3478, 3510], '1:1': [3481], 'mixture': [3482], 'F-12': [3484], 'medium': [3485, 3492, 3552, 3658, 3663, 4059], 'glutamine': [3487], "Dulbecco's": [3489, 4056], 'modified': [3490, 3550, 4057], "Eagle's": [3491, 3551, 4058], 'supplemented': [3493, 3518, 3556, 4060], '10%': [3495, 3520, 3558, 4062], 'FCS,': [3496, 3521, 3560, 4063], '100': [3497, 3501, 3529, 3533, 3561, 3565, 4064, 4068], 'μl/ml': [3498, 3502, 3530, 3534, 3562, 3566, 4065, 4069], 'penicillin,': [3499, 3531, 3563, 4066], 'streptomycin': [3503], '(Life': [3504, 3514, 3526, 3553, 3592, 4096], 'Technologies,': [3505, 3515, 3527, 3554, 3593, 4097], 'Inc.).': [3506, 4098], 'MCF-7': [3507, 3540], 'RPMI': [3512], '1640': [3513], 'Inc.)': [3516, 3555, 3594], 'media': [3517], '1%': [3522, 3989], 'non-essential': [3523], 'acids': [3525], 'Inc.),': [3528], 'streptomycin.': [3535, 3567, 4070], 'plated': [3543, 4048], 'onto': [3544], '6-well': [3545, 4050], 'phenol': [3548, 3665], 'red-free': [3549], 'charcoal-stripped': [3559], 'Twenty-four': [3568, 4071], 'hours': [3569, 4072], 'later,': [3570, 4073], 'transfected': [3573, 3584, 3601, 3650, 4076], 'plasmid': [3575, 3651], 'Lipofectin': [3578, 4090], '(MCF-7': [3579], 'Gal-ERαLBD)': [3586], 'instructed': [3588, 3607, 4092], 'manufacturer': [3591, 3610, 4095], 'DOTAP': [3598], '(293': [3599], 'ERβ)': [3605], '(Boehringer': [3611], 'Mannheim).': [3612], 'Transfections': [3613], '1.0': [3617], 'ERE-tk-luciferase': [3620], '0.8': [3623], 'ERE-TATA-luc': [3626], 'reporter,': [3627], '0.2': [3630], '50': [3638, 3885], 'ng': [3639], 'Gal-ERαLBD.': [3641], 'Empty': [3642], 'equalize': [3648], 'total': [3649, 3735], 'concentrations.': [3653], 'After': [3654, 3887], 'h,': [3656], 'changed,': [3660], 'fresh': [3662], '(without': [3664], 'red)': [3666], 'Me2SO': [3668], '10': [3670, 4131], 'nm': [3671], 'added.': [3674], '30': [3675, 3807], 'after': [3677, 4105], 'changing': [3678], 'media,': [3679], 'harvested.': [3683], 'extracts': [3685], 'luciferase': [3689], '51Treuter': [3711, 4191], 'Total': [3731], 'RNA': [3732], 'preparation': [3737], '(52Spyrou': [3742, 3850, 3939], 'Miranda-Vizuete': [3746, 3854, 3943], '2936-2941Abstract': [3755, 3863, 3952], '(333)': [3763, 3871, 3960], 'reaction,': [3769], 'μl': [3771], 'synthesized': [3774], 'mix': [3781], 'amplified,': [3783], 'starting': [3784], 'preincubation': [3787], '94': [3789, 3799], '°C': [3790, 3800, 3805, 3811, 3971, 3993, 4013], 'min,': [3793], '25': [3796], 'cycles': [3797], '20': [3802], 's,': [3803, 3808], '56': [3804], '72': [3810], '90': [3813], 's': [3814], '9600': [3818], 'thermocycler': [3819], '(Perkin-Elmer).': [3820], 'oligonucleotides': [3822, 3840], 'R1051': [3823], '5′-AGGAACAAGACACAGACCATGAGCT-3′': [3824], 'R1031': [3826], '5′-AGTCCTTGGACGGCAGGAAGACGG-3′': [3827], 'used': [3829, 3841, 4169], '258-base': [3834, 3904], 'pair': [3835, 3905], 'actin': [3845, 3877, 3924, 3932, 4007], 'annealing': [3882], 'temperature': [3883, 4034, 4122], 'agarose': [3888], 'blotting': [3892], 'nitrocellulose': [3894], 'filters,': [3895], 'hybridized': [3900, 3928], 'labeled': [3903], 'oligonucleotide': [3907, 4008], 'prepared': [3908], 'clone,': [3914], 'primers': [3918], 'RT-PCR.': [3922], 'internal': [3931], 'primer,': [3933], 'according': [3934], 'protocol': [3938], 'Hybridization': [3963, 4005], 'probe': [3966], '65': [3970, 3992], 'ExpressHyb': [3976, 4018], 'hybridization': [3977, 4019], 'four': [3982, 4023], '20-min': [3983, 3997, 4038], 'washes': [3984, 3998, 4025, 4039], '2×': [3986, 4027], 'SSC': [3987, 4001, 4028, 4042], 'SDS': [3990, 4031], 'finally': [3995, 4036], '0.1×': [4000, 4041], '0.5%': [4003], 'SDS.': [4004, 4045], '37': [4012], '10-min': [4024], '0.05%': [4030], 'room': [4033, 4121, 4134], '0.1%': [4044], '293-cells': [4046], 'glass': [4053], 'coverslips': [4054, 4137], 'SHP-GFP': [4081], 'GFP': [4087], 'alone,': [4088], 'Cellular': [4099], 'visualized': [4102], '36': [4103], 'transfection.': [4106], 'fixed': [4110], '4%': [4112], 'formaldehyde': [4113], 'phosphate-buffered': [4115], 'saline': [4116], '15': [4118], 'min': [4119, 4132], 'stained': [4124], '0.001': [4126], 'mg/ml': [4127], 'Hoechst': [4128], '33342': [4129], 'temperature.': [4135], 'mounted': [4139], 'micro': [4141], 'slides': [4142], 'FluorSave': [4144], 'Reagent': [4145], '(Calbiochem)': [4146], 'viewing': [4149], 'Zeiss': [4152], 'Axiophot': [4153], 'epifluorescence': [4154], 'microscope.': [4155], 'Photographs': [4156], 'recorded': [4158], 'T-max': [4160], '400': [4161], 'film': [4162], '(Kodak).': [4163], 'approach': [4167], 'PPARα,': [4180], 'beyond': [4181], 'known': [4183], 'details': [4188], 'Ref.': [4190, 4236], 'Screening': [4211], 'domain-tagged': [4215], 'led': [4220], 'independent': [4225], 'partial': [4226], 'clones': [4227], 'encoding': [4228, 4265], 'RXRβ,': [4229], 'dUTPase': [4230], '(a': [4231], 'characterized': [4233], 'PPAR-interacting': [4234], '53Chu': [4237], 'R.Y.': [4238], 'Rao': [4241], 'M.S.': [4242], 'Reddy': [4243], '271:': [4249], '27670-27676Abstract': [4250], '(34)': [4258], 'one': [4262], 'compared': [4292], 'mouse': [4295], 'orthologues': [4298], 'consists': [4300], '260': [4302], 'aa': [4303], 'molecular': [4307], 'mass': [4308], '29': [4310], 'kDa,': [4311], 'concordance': [4313], 'recently': [4315], 'published': [4316], 'data': [4317], '(45Masuda': [4318], 'RACE': [4345], 'experiments': [4346], 'failed': [4347], 'detect': [4349], 'extended': [4350], '5′-coding': [4351], '(data': [4353], 'shown),': [4355], 'supporting': [4356], 'view': [4358], 'Structural': [4367], 'features': [4368], 'i': [4372]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029725115', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-08T19:00:30.685356', 'created_date': '2016-06-24'}
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