Publication Information

{'id': 'https://openalex.org/W2134155634', 'doi': 'https://doi.org/10.1128/mcb.20.4.1124-1133.2000', 'title': 'The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors', 'display_name': 'The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors', 'publication_year': 2000, 'publication_date': '2000-02-01', 'ids': {'openalex': 'https://openalex.org/W2134155634', 'doi': 'https://doi.org/10.1128/mcb.20.4.1124-1133.2000', 'mag': '2134155634', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10648597', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/85230'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.20.4.1124-1133.2000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc85230?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086047305', 'display_name': 'Lotta Johansson', 'orcid': 'https://orcid.org/0000-0002-5039-7144'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Lotta Johansson', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute, Sweden '], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute, Sweden ', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039523676', 'display_name': 'Ann Båvner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ann Båvner', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048366429', 'display_name': 'Jane S. Thomsen', 'orcid': 'https://orcid.org/0000-0002-9336-5695'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Jane S. Thomsen', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013991412', 'display_name': 'Mathias Färnegårdh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114222', 'display_name': 'Karo Pharma (Sweden)', 'ror': 'https://ror.org/0219mbj11', 'country_code': 'SE', 'type': 'company', 'lineage': ['https://openalex.org/I4210114222']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Mathias Färnegårdh', 'raw_affiliation_strings': ['Karo Bio', 'KaroBio AB, S-14157 Huddinge, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Karo Bio', 'institution_ids': ['https://openalex.org/I4210114222']}, {'raw_affiliation_string': 'KaroBio AB, S-14157 Huddinge, Sweden', 'institution_ids': ['https://openalex.org/I4210114222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085801141', 'display_name': 'Jan-Ακε Gustafsson', 'orcid': 'https://orcid.org/0000-0002-1472-1373'}, 'institutions': [{'id': 'https://openalex.org/I1295876152', 'display_name': 'Houston Methodist', 'ror': 'https://ror.org/027zt9171', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1295876152']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jan-Åke Gustafsson', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute', 'Houston Methodist'], 'affiliations': [{'raw_affiliation_string': 'Houston Methodist', 'institution_ids': ['https://openalex.org/I1295876152']}, {'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082190458', 'display_name': 'Eckardt Treuter', 'orcid': 'https://orcid.org/0000-0002-4147-8989'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Eckardt Treuter', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.775, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 157, 'citation_normalized_percentile': {'value': 0.999925, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '20', 'issue': '4', 'first_page': '1124', 'last_page': '1133'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/small-heterodimer-partner', 'display_name': 'Small heterodimer partner', 'score': 0.8071178}, {'id': 'https://openalex.org/keywords/pelp-1', 'display_name': 'PELP-1', 'score': 0.6309074}, {'id': 'https://openalex.org/keywords/estrogen-related-receptor-gamma', 'display_name': 'Estrogen-related receptor gamma', 'score': 0.60965353}, {'id': 'https://openalex.org/keywords/estrogen-receptor-beta', 'display_name': 'Estrogen receptor beta', 'score': 0.42645875}, {'id': 'https://openalex.org/keywords/transrepression', 'display_name': 'Transrepression', 'score': 0.41353613}], 'concepts': [{'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.8346931}, {'id': 'https://openalex.org/C183481951', 'wikidata': 'https://www.wikidata.org/wiki/Q15312971', 'display_name': 'Small heterodimer partner', 'level': 5, 'score': 0.8071178}, {'id': 'https://openalex.org/C195598365', 'wikidata': 'https://www.wikidata.org/wiki/Q14914583', 'display_name': 'Nuclear receptor coactivator 1', 'level': 5, 'score': 0.7320932}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.68054634}, {'id': 'https://openalex.org/C84750089', 'wikidata': 'https://www.wikidata.org/wiki/Q21130793', 'display_name': 'PELP-1', 'level': 5, 'score': 0.6309074}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.61087906}, {'id': 'https://openalex.org/C91977512', 'wikidata': 'https://www.wikidata.org/wiki/Q5401840', 'display_name': 'Estrogen-related receptor gamma', 'level': 5, 'score': 0.60965353}, {'id': 'https://openalex.org/C77445288', 'wikidata': 'https://www.wikidata.org/wiki/Q637488', 'display_name': 'Coactivator', 'level': 4, 'score': 0.60917795}, {'id': 'https://openalex.org/C124170894', 'wikidata': 'https://www.wikidata.org/wiki/Q14914591', 'display_name': 'Nuclear receptor coactivator 2', 'level': 5, 'score': 0.54421246}, {'id': 'https://openalex.org/C71931279', 'wikidata': 'https://www.wikidata.org/wiki/Q21163354', 'display_name': 'Nuclear receptor co-repressor 1', 'level': 5, 'score': 0.5405364}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5285146}, {'id': 'https://openalex.org/C33987129', 'wikidata': 'https://www.wikidata.org/wiki/Q13479514', 'display_name': 'DNA-binding domain', 'level': 4, 'score': 0.49672538}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.48554322}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.45482236}, {'id': 'https://openalex.org/C96307122', 'wikidata': 'https://www.wikidata.org/wiki/Q15329133', 'display_name': 'Estrogen receptor beta', 'level': 5, 'score': 0.42645875}, {'id': 'https://openalex.org/C59300778', 'wikidata': 'https://www.wikidata.org/wiki/Q7835354', 'display_name': 'Transrepression', 'level': 5, 'score': 0.41353613}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4054616}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20193878}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.17194945}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047629', 'descriptor_name': 'Estrogen Receptor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020836', 'descriptor_name': 'Protein Structure, Quaternary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.20.4.1124-1133.2000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc85230', 'pdf_url': 'https://europepmc.org/articles/pmc85230?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10648597', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc85230', 'pdf_url': 'https://europepmc.org/articles/pmc85230?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1487669901', 'https://openalex.org/W1501286679', 'https://openalex.org/W1596796792', 'https://openalex.org/W1613446635', 'https://openalex.org/W1806893674', 'https://openalex.org/W1864394606', 'https://openalex.org/W1965886467', 'https://openalex.org/W1971657931', 'https://openalex.org/W1979243778', 'https://openalex.org/W1986578326', 'https://openalex.org/W1993423079', 'https://openalex.org/W1995754186', 'https://openalex.org/W1996127793', 'https://openalex.org/W2006602286', 'https://openalex.org/W2008632158', 'https://openalex.org/W2011119018', 'https://openalex.org/W2013750319', 'https://openalex.org/W2020725121', 'https://openalex.org/W2029725115', 'https://openalex.org/W2035338941', 'https://openalex.org/W2040053707', 'https://openalex.org/W2042901562', 'https://openalex.org/W2051777413', 'https://openalex.org/W2070428103', 'https://openalex.org/W2071263028', 'https://openalex.org/W2074362522', 'https://openalex.org/W2076762200', 'https://openalex.org/W2077402732', 'https://openalex.org/W2084722787', 'https://openalex.org/W2091969321', 'https://openalex.org/W2094558395', 'https://openalex.org/W2094838095', 'https://openalex.org/W2101738855', 'https://openalex.org/W2101833345', 'https://openalex.org/W2106900373', 'https://openalex.org/W2111650618', 'https://openalex.org/W2113456624', 'https://openalex.org/W2134623365', 'https://openalex.org/W2139717510', 'https://openalex.org/W2141686420', 'https://openalex.org/W2142442530', 'https://openalex.org/W2144011606', 'https://openalex.org/W2156362611', 'https://openalex.org/W2165762583', 'https://openalex.org/W2167075350', 'https://openalex.org/W2605614532', 'https://openalex.org/W2904810104', 'https://openalex.org/W4212936275', 'https://openalex.org/W4241870034'], 'related_works': ['https://openalex.org/W4284879194', 'https://openalex.org/W4250112211', 'https://openalex.org/W2134155634', 'https://openalex.org/W2106213113', 'https://openalex.org/W2074335699', 'https://openalex.org/W2039074443', 'https://openalex.org/W2036940526', 'https://openalex.org/W2029725115', 'https://openalex.org/W2023307129', 'https://openalex.org/W1566567520'], 'abstract_inverted_index': {'SHP': [0, 37, 76, 118, 160, 171, 202, 231, 241], '(short': [1], 'heterodimer': [2], 'partner)': [3], 'is': [4], 'an': [5, 148, 258], 'unusual': [6], 'orphan': [7, 259], 'nuclear': [8, 25, 43, 109, 233, 260], 'receptor': [9, 44, 163, 195, 234], 'consisting': [10], 'only': [11], 'of': [12, 21, 31, 52, 59, 69, 100, 124, 139, 182, 211, 230], 'a': [13, 180, 206, 223, 244, 252], 'ligand-binding': [14, 133], 'domain,': [15, 185], 'and': [16, 64, 236, 254], 'it': [17], 'exhibits': [18], 'unique': [19, 255], 'features': [20], 'interaction': [22], 'with': [23, 113, 154, 214], 'conventional': [24], 'receptors.': [26, 110], 'While': [27], 'the': [28, 98, 103, 114, 120, 132, 157, 183, 188, 209, 227], 'mechanistic': [29, 224], 'basis': [30], 'these': [32], 'interactions': [33, 153], 'has': [34, 38], 'remained': [35], 'enigmatic,': [36], 'been': [39], 'suggested': [40], 'to': [41, 79, 88, 102, 145, 190], 'inhibit': [42, 191], 'activation': [45, 105, 164], 'by': [46], 'at': [47], 'least': [48], 'three': [49], 'alternatives;': [50], 'inhibition': [51], 'DNA': [53], 'binding': [54, 99, 138], 'via': [55, 62, 67, 82, 165, 208], 'dimerization,': [56], 'direct': [57], 'antagonism': [58], 'coactivator': [60], 'function': [61, 204, 256], 'competition,': [63], 'possibly': [65], 'transrepression': [66], 'recruitment': [68], 'putative': [70], 'corepressors.': [71], 'We': [72], 'now': [73], 'show': [74], 'that': [75, 159, 170, 201], 'binds': [77], 'directly': [78, 161], 'estrogen': [80, 126, 194], 'receptors': [81, 127, 216], 'LXXLL-related': [83], 'motifs.': [84], 'Similar': [85], 'motifs,': [86], 'referred': [87], 'as': [89, 205, 243], 'NR': [90, 115, 176], '(nuclear': [91], 'receptor)': [92], 'boxes,': [93], 'are': [94, 143], 'usually': [95], 'critical': [96], 'for': [97, 128, 226, 249, 257], 'coactivators': [101], 'ligand-regulated': [104], 'domain': [106, 123, 134], 'AF-2': [107, 122, 150, 166], 'within': [108, 131], 'In': [111], 'concordance': [112], 'box': [116, 177], 'dependency,': [117], 'requires': [119], 'intact': [121], 'agonist-bound': [125], 'interaction.': [129], 'Mutations': [130], 'helix': [135], '12,': [136], 'or': [137, 179, 247], 'antagonistic': [140], 'ligands,': [141], 'which': [142], 'known': [144], 'result': [146], 'in': [147, 232], 'incomplete': [149], 'surface,': [151], 'abolish': [152], 'SHP.': [155], 'Supporting': [156], 'idea': [158], 'antagonizes': [162], 'binding,': [167], 'we': [168], 'demonstrate': [169], 'variants,': [172], 'carrying': [173], 'either': [174], 'interaction-defective': [175], 'mutations': [178], 'deletion': [181], 'repressor': [184], 'have': [186], 'lost': [187], 'capacity': [189], 'agonist-dependent': [192], 'transcriptional': [193], 'activation.': [196], 'Furthermore,': [197], 'our': [198], 'studies': [199], 'indicate': [200], 'may': [203, 238], 'cofactor': [207], 'formation': [210], 'ternary': [212], 'complexes': [213], 'dimeric': [215], 'on': [217], 'DNA.': [218], 'These': [219], 'novel': [220, 253], 'insights': [221], 'provide': [222], 'explanation': [225], 'inhibitory': [228], 'role': [229], 'signaling,': [235], 'they': [237], 'explain': [239], 'how': [240], 'functions': [242], 'negative': [245], 'coregulator': [246], 'corepressor': [248], 'ligand-activated': [250], 'receptors,': [251], 'receptor.': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2134155634', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-13T17:36:27.204053', 'created_date': '2016-06-24'}