Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2029234230', 'doi': 'https://doi.org/10.1016/j.freeradbiomed.2009.08.001', 'title': 'Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells', 'display_name': 'Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells', 'publication_year': 2009, 'publication_date': '2009-08-11', 'ids': {'openalex': 'https://openalex.org/W2029234230', 'doi': 'https://doi.org/10.1016/j.freeradbiomed.2009.08.001', 'mag': '2029234230', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19666105', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2846758'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.freeradbiomed.2009.08.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128018148', 'display_name': 'Free Radical Biology and Medicine', 'issn_l': '0891-5849', 'issn': ['0891-5849', '1873-4596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2846758?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052440393', 'display_name': 'Zefen Wang', 'orcid': 'https://orcid.org/0000-0002-4290-0379'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zefen Wang', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044870092', 'display_name': 'Hong Yang', 'orcid': 'https://orcid.org/0000-0001-6463-684X'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hong Yang', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026951278', 'display_name': 'Aramandla Ramesh', 'orcid': 'https://orcid.org/0000-0003-0688-9368'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aramandla Ramesh', 'raw_affiliation_strings': ['Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105886379', 'display_name': 'L. Jackson Roberts', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. Jackson Roberts', 'raw_affiliation_strings': ['Department of Pharmacology Vanderbilt University Nashville, TN 37232 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology Vanderbilt University Nashville, TN 37232 USA', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028540232', 'display_name': 'Lichun Zhou', 'orcid': 'https://orcid.org/0000-0002-6935-1250'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'LiChun Zhou', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008554297', 'display_name': 'Xinhua Lin', 'orcid': 'https://orcid.org/0000-0002-9380-8417'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xinhua Lin', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101743417', 'display_name': 'Yanfeng Zhao', 'orcid': 'https://orcid.org/0000-0001-5037-8077'}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yanfeng Zhao', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5104111482', 'display_name': 'ZhongMao Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118073183', 'display_name': 'Meharry Medical College', 'ror': 'https://ror.org/00k63dq23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I118073183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ZhongMao Guo', 'raw_affiliation_strings': ['Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Biology, Meharry Medical College, Nashville, TN 37208, USA.', 'institution_ids': ['https://openalex.org/I118073183']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3740, 'currency': 'USD', 'value_usd': 3740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.573, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.80238, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '47', 'issue': '8', 'first_page': '1221', 'last_page': '1229'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10122', 'display_name': 'Impact of Persistent Organic Pollutants on Environment and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10122', 'display_name': 'Impact of Persistent Organic Pollutants on Environment and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10686', 'display_name': 'Endocrine Disruption by Chemical Exposure', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Genotoxicity and Carcinogenesis Mechanisms', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp1b1', 'display_name': 'CYP1B1', 'score': 0.68891907}, {'id': 'https://openalex.org/keywords/dismutase', 'display_name': 'Dismutase', 'score': 0.5514187}, {'id': 'https://openalex.org/keywords/bisphenol-a', 'display_name': 'Bisphenol A', 'score': 0.46844}], 'concepts': [{'id': 'https://openalex.org/C33594762', 'wikidata': 'https://www.wikidata.org/wiki/Q155750', 'display_name': 'Aryl hydrocarbon receptor', 'level': 4, 'score': 0.89786446}, {'id': 'https://openalex.org/C2778979269', 'wikidata': 'https://www.wikidata.org/wiki/Q106951292', 'display_name': 'Catalase', 'level': 3, 'score': 0.87291527}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.7755201}, {'id': 'https://openalex.org/C155701950', 'wikidata': 'https://www.wikidata.org/wiki/Q14905165', 'display_name': 'CYP1B1', 'level': 4, 'score': 0.68891907}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.66193247}, {'id': 'https://openalex.org/C2777538855', 'wikidata': 'https://www.wikidata.org/wiki/Q306051', 'display_name': 'Benzo(a)pyrene', 'level': 3, 'score': 0.65640795}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.5803253}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.57376355}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.5649481}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5545079}, {'id': 'https://openalex.org/C2778248901', 'wikidata': 'https://www.wikidata.org/wiki/Q5282371', 'display_name': 'Dismutase', 'level': 4, 'score': 0.5514187}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.38550842}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35636398}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.27541435}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.26727444}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26600224}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.26168972}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.16250652}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.1163581}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09621754}], 'mesh': [{'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001564', 'descriptor_name': 'Benzo(a)pyrene', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018336', 'descriptor_name': 'Receptors, Aryl Hydrocarbon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001564', 'descriptor_name': 'Benzo(a)pyrene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019363', 'descriptor_name': 'Cytochrome P-450 CYP1A1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019363', 'descriptor_name': 'Cytochrome P-450 CYP1A1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019363', 'descriptor_name': 'Cytochrome P-450 CYP1A1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065633', 'descriptor_name': 'Cytochrome P-450 CYP1B1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028441', 'descriptor_name': 'F2-Isoprostanes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D028441', 'descriptor_name': 'F2-Isoprostanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005663', 'descriptor_name': 'Furans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005663', 'descriptor_name': 'Furans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008658', 'descriptor_name': 'Inactivation, Metabolic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018336', 'descriptor_name': 'Receptors, Aryl Hydrocarbon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018336', 'descriptor_name': 'Receptors, Aryl Hydrocarbon', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D018336', 'descriptor_name': 'Receptors, Aryl Hydrocarbon', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.freeradbiomed.2009.08.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128018148', 'display_name': 'Free Radical Biology and Medicine', 'issn_l': '0891-5849', 'issn': ['0891-5849', '1873-4596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2846758', 'pdf_url': 'https://europepmc.org/articles/pmc2846758?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846758', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19666105', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2846758', 'pdf_url': 'https://europepmc.org/articles/pmc2846758?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1491876634', 'https://openalex.org/W1607814610', 'https://openalex.org/W1823753392', 'https://openalex.org/W1881840670', 'https://openalex.org/W1964109666', 'https://openalex.org/W1968055952', 'https://openalex.org/W1969705796', 'https://openalex.org/W1993114600', 'https://openalex.org/W2009630930', 'https://openalex.org/W2023694479', 'https://openalex.org/W2027487946', 'https://openalex.org/W2029275372', 'https://openalex.org/W2030005694', 'https://openalex.org/W2034827383', 'https://openalex.org/W2046688237', 'https://openalex.org/W2049041780', 'https://openalex.org/W2049533791', 'https://openalex.org/W2050572437', 'https://openalex.org/W2051502288', 'https://openalex.org/W2052089730', 'https://openalex.org/W2058887941', 'https://openalex.org/W2062467703', 'https://openalex.org/W2064230641', 'https://openalex.org/W2067548005', 'https://openalex.org/W2071789781', 'https://openalex.org/W2075763186', 'https://openalex.org/W2077082949', 'https://openalex.org/W2086592404', 'https://openalex.org/W2092195942', 'https://openalex.org/W2092905174', 'https://openalex.org/W2094053990', 'https://openalex.org/W2108390397', 'https://openalex.org/W2111380936', 'https://openalex.org/W2120840411', 'https://openalex.org/W2128422235', 'https://openalex.org/W2128603046', 'https://openalex.org/W2129429202', 'https://openalex.org/W2145337751', 'https://openalex.org/W2145744724', 'https://openalex.org/W2146909058', 'https://openalex.org/W2171144852', 'https://openalex.org/W2419374242', 'https://openalex.org/W3021097595'], 'related_works': ['https://openalex.org/W4249775543', 'https://openalex.org/W4237548399', 'https://openalex.org/W4231314374', 'https://openalex.org/W3085591596', 'https://openalex.org/W3038527732', 'https://openalex.org/W2124739658', 'https://openalex.org/W2108893850', 'https://openalex.org/W2058217363', 'https://openalex.org/W1974048771', 'https://openalex.org/W1964422998'], 'abstract_inverted_index': {'A': [0], 'reduction': [1], 'in': [2, 8, 16, 31, 59, 81, 87, 117, 124, 145, 149], 'endogenously': [3], 'generated': [4], 'reactive': [5, 112], 'oxygen': [6], 'species': [7], 'vivo': [9], 'delays': [10], 'benzo(a)pyrene': [11], '(BaP)-accelerated': [12], 'atherosclerosis,': [13], 'as': [14, 204], 'revealed': [15], 'hypercholesterolemic': [17], 'mice': [18], 'overexpressing': [19, 119], 'Cu/Zn-superoxide': [20], 'dismutase': [21], '(SOD)': [22], 'and/or': [23, 41, 72, 121, 191], 'catalase.': [24], 'To': [25], 'understand': [26], 'the': [27, 37, 82, 92, 98, 108, 129, 171], 'molecular': [28], 'events': [29], 'involved': [30], 'this': [32], 'protective': [33], 'action,': [34], 'we': [35], 'studied': [36], 'effects': [38], 'of': [39, 70, 84, 94, 110, 165, 176, 189, 197], 'Cu/Zn-SOD': [40, 71, 120, 172, 190], 'catalase': [42, 73, 122, 174, 192], 'overexpression': [43, 69, 188], 'on': [44, 48], 'BaP': [45, 90, 111, 182], 'detoxification': [46], 'and': [47, 54, 107, 132, 136, 155, 173, 181, 199], 'aryl': [49], 'hydrocarbon': [50], 'receptor': [51], '(AhR)': [52], 'expression': [53, 58, 83], 'its': [55, 200], 'target': [56, 201], 'gene': [57], 'mouse': [60], 'aortic': [61], 'endothelial': [62], 'cells': [63], '(MAECs).': [64], 'Our': [65], 'data': [66, 185], 'demonstrate': [67, 186], 'that': [68, 187], 'leads': [74], 'to': [75, 78, 97, 160], 'an': [76], '18-': [77], '20-fold': [79], 'increase': [80], 'AhR': [85, 95, 166, 198], 'protein': [86, 134], 'MAECs.': [88, 162], 'After': [89], 'exposure,': [91], 'amount': [93], 'binding': [96], 'cytochrome': [99], 'P450': [100], '(CYP)': [101], '1A1': [102], 'promoter': [103], 'was': [104], 'significantly': [105, 115, 143], 'greater,': [106], 'concentrations': [109], 'intermediates': [113], 'were': [114, 142], 'less': [116], 'MAECs': [118], 'than': [123], 'wild-type': [125, 161], 'cells.': [126], 'In': [127], 'addition,': [128], 'BaP-induced': [130], 'CYP1A1': [131, 177], '1B1': [133], 'levels': [135], 'BaP-elevated': [137], 'glutathione': [138], 'S-transferase': [139], '(GST)': [140], 'activity': [141], 'higher': [144], 'these': [146], 'transgenic': [147], 'cells,': [148], 'parallel': [150], 'with': [151, 167, 195], 'elevated': [152], 'GSTp1,': [153], 'CYP1A1,': [154], 'CYP1B1': [156], 'mRNA': [157], 'levels,': [158], 'compared': [159], 'Moreover,': [163], 'knockdown': [164], 'RNA': [168], 'interference': [169], 'diminished': [170], 'enhancement': [175], 'expression,': [178], 'GST': [179], 'activity,': [180], 'detoxification.': [183], 'These': [184], 'is': [193], 'associated': [194], 'upregulation': [196], 'genes,': [202], 'such': [203], 'xenobiotic-metabolizing': [205], 'enzymes.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2029234230', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-19T01:12:59.654788', 'created_date': '2016-06-24'}