Publication Information

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646, 813, 1009, 1920], 'SERCA2a': [138, 341, 367, 385, 595, 673, 1571, 2238], 'is': [139, 265, 271, 282, 410, 427, 471, 969, 996, 1016, 1295], 'being': [140], 'currently': [141], 'considered': [142], 'as': [143, 918, 920], 'a': [144, 166, 169, 208, 330, 825, 897, 1291, 1367, 1642, 1983, 2346], 'modality': [145], 'for': [146, 500, 503, 790, 815, 824, 1002, 1188, 1420, 1465, 1614, 1645, 1862, 2241, 2245, 2342, 2431, 2523, 2549], 'treatment': [148, 817, 2433], 'heart': [150, 504, 605, 724, 819, 847, 1156, 1398, 1423, 1616, 1651, 2344, 2392, 2435], 'failure,2': [151], 'al': [157], 'has': [158, 347, 373, 420, 446, 823, 955], 'potential': [160], 'raising': [162], 'concern': [163, 995], 'about': [164], 'such': [165], 'strategy.': [167], 'However,': [168], 'number': [170], 'limitations': [172], 'this': [174, 275, 296, 1089], 'study': [175, 276, 297, 332, 392, 1369], 'preclude': [176], 'any': [177], 'definitive': [178], 'conclusions': [179, 293], 'regarding': [180, 843], 'toxicity': [182], 'overexpressing': [184], 'SERCA.': [185], 'The': [186, 267, 292, 1320, 2489], 'authors': [187, 243], 'demonstrated': [188, 910, 957], 'expression': [190, 224, 365, 431, 470, 902, 990, 1047, 1057, 1863], 'noncardiac': [193], 'isoform': [194, 228, 954], 'SERCA1': [195, 227, 250, 287, 953], 'embryonic': [197, 404], 'myocytes': [201, 346, 929], 'their': [203, 932], 'studies.': [204], 'These': [205], 'cardiomyocytes': [206, 538, 639], 'have': [207, 1027], 'poorly': [209], 'developed': [210], 'do': [214], 'not': [215, 283, 437, 801, 925, 958, 1054], 'represent': [216], 'functionally': [217], 'adult': [219, 343, 359, 681, 928], 'heart.': [220], 'In': [221, 361, 849, 880], 'addition,': [222, 362], 'may': [229], 'result': [230], 'abnormal': [232, 1361], 'intracellular': [233], 'trafficking,': [234], 'which': [235, 270, 936, 1015, 1074], 'results': [236, 308], 'irregular': [238], 'calcium': [239, 477, 561, 729, 2028, 2403], 'signaling.': [240, 906], 'Although': [241, 390], 'state': [244], 'that': [245, 310, 338, 414, 430, 863, 896, 1088], 'cytotoxic': [246, 398, 481, 1038, 1056], 'effects': [247, 349, 399, 482, 553, 942], 'observed': [248], 'overexpression': [251, 288, 311, 339, 674, 764], 'are': [252, 298, 864], '"slightly"': [253], 'higher': [254], 'than': [255], 'empty': [258], 'or': [259, 289, 371, 855], 'reporter': [260], 'viruses,': [261], 'no': [262], 'statistical': [263, 869], 'significance': [264], 'shown.': [266], 'apoptosis': [268, 535], 'index,': [269], 'unusually': [272], 'high': [273], 'compared': [277], 'other': [279], 'published': [280], 'studies,3': [281], 'reportedly': [284], 'different': [285, 2314], 'between': [286], 'GFP': [290], 'overexpression.': [291], 'drawn': [294], 'direct': [300], 'contrast': [301, 351], 'those': [303], 'validated': [304], 'numerous': [306], 'experimental': [307, 944], 'showing': [309], 'isoform,': [315, 435], 'SERCA2a,': [316, 436, 2592], 'improves': [317, 596, 904, 1929], 'contractility': [318, 772, 1649, 1773, 1819], 'both': [319, 1003], 'vivo': [321], 'vitro': [324], 'without': [325], 'detrimental': [326, 421], 'effects.456': [327], 'Most': [328], 'importantly,': [329], 'recent': [331], 'Davia': [334, 652], 'al7': [336], 'showed': [337, 884], 'rabbit': [344, 682], 'protective': [348, 447], 'β-agonism': [353], 'prolongs': [355], 'survival': [356, 934], 'these': [358, 881], 'cardiomyocytes.': [360], 'exogenous': [364, 468, 1007, 1059], 'either': [369], 'transgenesis': [370], 'adenovirus': [372], 'ranged': [374], 'from': [375, 640, 2275, 2351], '1.13-': [376], '2-fold,489': [378], 'pointing': [379], 'toward': [380], 'an': [381], 'endogenous': [382], 'regulation': [383, 977, 2477], 'levels': [386, 988], 'cells.': [389], 'describes': [397], 'recombinant': [401], 'adenoviruses': [402], 'myocytes,': [408], 'there': [409, 426], 'very': [411], 'little': [412], 'evidence': [413, 429, 1861], 'exogenously': [415], 'increasing': [416], 'SR': [417], 'activity': [419], 'effects.': [422, 448], 'On': [423], 'contrary,': [425], 'ample': [428], 'only': [438, 959], 'rescues': [439], 'contractile': [440, 635, 2025], 'function': [441, 598, 636, 1396, 1930], 'failing': [443, 641, 1024, 2218], 'hearts': [444, 643, 857, 1829], 'but': [445, 963, 1820], 'References': [449], '1': [450, 1690], 'JM,': [452], 'Sumbilla': [453], 'CM,': [454, 662], 'Ma': [455], 'H,': [456, 692, 1503, 1743, 1804, 1806, 1963, 2071, 2158, 2452, 2460, 2464], 'Farrance': [457], 'IKG,': [458], 'Cavagna': [459], 'M,': [460, 706, 1552, 1669, 1792, 1851, 1951, 2003, 2119, 2123, 2168, 2374, 2561], 'Klein': [461], 'MG,': [462], 'Inesi': [463], 'G.': [464], 'Tight': [465], 'control': [466, 1256], 'required': [472], 'obtain': [474, 859], 'acceleration': [475], 'transients': [478, 730], 'minimal': [480], 'Circ': [486, 506, 777], 'Res.2001;': [487], '88:415–421.CrossrefMedlineGoogle': [488], 'Scholar2': [489], 'RJ,': [491, 522, 545, 670], 'F,': [494, 516, 574, 616, 660, 1309, 1450, 1905], 'Matsui': [495, 510, 581, 621], 'T,': [496, 511, 582, 622, 748, 1499, 1955, 2125, 2203, 2261], 'Rosenzweig': [497, 523, 550, 587, 629], 'A.': [498, 524, 551], 'Prospects': [499], 'therapy': [502, 1392, 2430], 'failure.': [505, 606, 848], 'Res.2000;': [507], '86:616–621.CrossrefMedlineGoogle': [508], 'Scholar3': [509], 'Li': [512, 1141, 1340, 1795], 'L,': [513, 1213, 1442, 1446, 1452, 1542, 1898, 2160, 2378, 2466, 2563], 'Fukui': [517], 'Y,': [518, 746, 1215, 1759, 1796, 1798, 2567], 'Franke': [519], 'TF,': [520], 'Adenoviral': [525, 591], 'activated': [529], 'phosphatidylinositol': [530], '3′-kinase': [531], 'Akt': [533], 'inhibits': [534], 'hypoxic': [537], 'vitro.': [540], 'Circulation.1999;': [541, 649], '100:2373–2379.CrossrefMedlineGoogle': [542], 'Scholar4': [543], 'Kang': [546, 579, 623], 'JX,': [547], 'Gwathmey': [548, 585, 627], 'JK,': [549, 586, 628], 'Physiological': [552, 2142], 'adenoviral': [555], 'isolated': [564, 638], 'rat': [565, 716, 2319], 'Circulation.1997;': [567], '95:423–429.CrossrefMedlineGoogle': [568], 'Scholar5': [569], 'Miyamoto': [570], 'MI,': [571], 'Schmidt': [575, 619], 'U,': [576, 620, 2009, 2162, 2164], 'DiSalvo': [577], 'TS,': [578], 'ZB,': [580, 624], 'Guerrero': [583], 'JL,': [584], 'A,': [588, 630, 754, 1142, 1177, 1205, 1217, 1444, 1606, 1711, 1894, 2454], 'RJ.': [590, 632], 'left-ventricular': [597], 'aortic-banded': [600], 'rats': [601], 'transition': [603], 'Proc': [607], 'Natl': [608], 'Acad': [609], 'Sci': [610], 'USA.2000;': [611], '97:793–798.Google': [612], 'Scholar6': [613], 'SE,': [618], 'Dec': [625], 'GW,': [626], 'Restoration': [633], 'human': [642, 1164], 'SERCA2a.': [648], '100:2308–2311.CrossrefMedlineGoogle': [650], 'Scholar7': [651], 'K,': [653, 742, 1961, 2013, 2376, 2468], 'Bernobich': [654], 'E,': [655, 710, 750, 760, 1248, 1440, 1497, 1554, 1747, 2297, 2571], 'Ranu': [656], 'HR,': [657], 'Terracciano': [661, 2017], 'MacLeod': [663], 'KT,': [664], 'Adamson': [665], 'DL,': [666, 740], 'Chaudhri': [667], 'B,': [668, 756, 1221, 1345, 1505, 1534, 1560, 1949, 1959, 2370], 'SE.': [672], 'decreases': [675], 'incidence': [677], 'aftercontractions': [679], 'ventricular': [683, 2483], 'J': [685, 734, 1116, 1564, 1639, 1716, 2134, 2175, 2266], 'Mol': [686], 'Cell': [687, 1262], 'Cardiol.2001;': [688], '33:1005–1115.CrossrefMedlineGoogle': [689], 'Scholar8': [690], 'He': [691], 'Giordano': [693], 'FJ,': [694], 'Hilal-Dandan': [695], 'R,': [696, 758, 1276, 1900, 1907, 1911, 2201, 2458, 2573], 'Choi': [697], 'DJ,': [698], 'Rockman': [699], 'HA,': [700], 'McDonough': [701], 'PM,': [702], 'Bluhm': [703], 'WF,': [704], 'Meyer': [705, 2463], 'Sayen': [707], 'MR,': [708], 'Swanson': [709], 'Dillmann': [711], 'WH.': [712], 'Overexpression': [713], 'transgenic': [726, 774, 966, 975], 'mice': [727, 2395], 'accelerates': [728], 'relaxation.': [733], 'Clin': [735], 'Invest.1997;': [736], '100:380–389.CrossrefMedlineGoogle': [737], 'Scholar9': [738], 'Baker': [739], 'Hashimoto': [741], 'Grupp': [743, 751], 'IL,': [744], 'Ji': [745], 'Reed': [747], 'Loukianov': [749], 'G,': [752, 1544, 1558, 1595, 1599, 1601, 1902, 2007, 2127, 2382], 'Bhagwhat': [753], 'Hoit': [755], 'Walsh': [757], 'Marbán': [759], 'Periasamy': [761, 2095, 2232, 2386], 'M.': [762], 'Targeted': [763], 'Ca2+-ATPase': [769], 'increases': [770, 1771], 'mouse': [775], 'hearts.': [776, 1025], 'Res.1998;': [778], '83:1205–1214.CrossrefMedlineGoogle': [779], 'ScholarcircresahaCirc': [780], 'ResCirculation': [781], 'ResearchCirculation': [782], 'Research0009-73301524-4571Lippincott': [783], 'Williams': [784], '&': [785, 1582, 2061, 2529], 'WilkinsResponseInesi': [786], 'Giuseppe08062001I': [787], 'am': [788], 'gratified': [789], 'elicited': [793], 'our': [795, 850, 961], 'study.R1': [796], 'With': [797], 'it,': [798], 'we': [799, 852, 883, 892], 'did': [800, 893], 'mean': [802], 'raise': [804], 'obstacles': [805], 'laudable': [807], 'attempts': [808], 'develop': [810], 'modalities': [814], 'failure.R2': [820], 'Our': [821, 994], 'laboratory': [822], 'long': [826], 'time': [827], 'generated': [828], 'basic': [829], 'information,': [830], 'including': [831, 871], 'original': [833], 'description': [834], 'SERCA,R3': [837], 'leading': [838], 'present': [841], 'its': [844], 'role': [845], 'experiments,': [851], 'use': [853, 1042, 1080], 'embryo': [854], 'reliable': [860], 'myocyte': [861], 'cultures': [862], 'suited': [865], 'quantitative': [867], 'measurements,': [870], 'accurate': [872], 'determination': [873], 'catalytic': [875], 'turnover': [876], 'various': [878], 'isoforms.R4': [879], 'preparations,': [882], 'development': [887, 1094], 'confocal': [889], 'microscopy,': [890], 'indeed': [894], 'find': [895], '2-fold': [898], 'increase': [899], 'level': [903], 'This': [907], 'was': [909], 'complementary': [912], 'indicators': [914], 'yield': [916], 'kinetic': [917], 'well': [919], 'stoichiometric': [921], 'measurements.R5': [922], 'We': [923, 1026, 1086], 'prefer': [924], 'culture': [927], 'because': [930], 'low': [933], 'rate,': [935], 'precludes': [937], 'meaningful': [938], 'statistics': [939], 'perturbations': [945], 'survival.': [947], 'An': [948], 'advantageous': [949], 'switch': [950], 'been': [956], 'experimentsR4': [962], 'also': [964], 'animals.R6': [967], 'It': [968], 'important': [970], 'recognize': [972], 'that,': [973], 'animals,': [976], 'untranslated': [979], 'regions': [980], 'occurrence': [982], 'compensatory': [984], 'mechanisms': [985, 1722], 'allow': [986], 'safe': [987, 1004, 1096], 'surviving': [992], 'animals.': [993], 'related': [997], 'establishment': [999], 'conditions': [1001], 'effective': [1006, 1098], 'means': [1011], 'viral': [1013, 1034], 'vectors,': [1014], 'likely': [1017], 'method': [1019], 'be': [1021, 1076], 'used': [1022], 'made': [1028], 'careful': [1029], 'efforts': [1030], 'restrict': [1032], 'titer': [1035], 'avoid': [1037], 'effectsR1': [1039], 'cell-specific': [1043], 'promoters': [1044], 'limit': [1046], 'muscle.R7': [1050], 'Certainly': [1051], 'one': [1052], 'would': [1053, 1075], 'want': [1055], 'smooth': [1062], 'muscle,': [1063], 'endothelium,': [1064], 'even': [1066], 'liver': [1067], 'cells': [1068], '(in': [1069], 'addition': [1070], 'myocytes),': [1073], 'obtained': [1077], 'nondiscriminative': [1079], 'strong': [1082], 'constitutive': [1084], 'promoters.': [1085], 'hope': [1087], 'information': [1090], 'will': [1091], 'help': [1092], 'methods': [1099], 'transfer.': [1102], 'Previous': [1103], 'Back': [1104], 'top': [1106], 'Next': [1107], 'FiguresReferencesRelatedDetailsCited': [1108], 'ByKieserman': [1109], 'J,': [1110, 1144, 1201, 1280, 1538, 1556, 1663, 1665, 1739, 1745, 1749, 1763, 1810, 1892, 2001, 2117, 2295, 2301, 2368, 2380], 'Myers': [1111], 'V,': [1112, 1278, 1532, 1540], 'Dubey': [1113], 'P,': [1114, 1207, 1209, 1274, 1546, 1593, 1909, 2156, 2166, 2299], 'Cheung': [1115], 'Feldman': [1118], 'A': [1119, 1315, 1459, 1461, 1855, 2073, 2172, 2236, 2474, 2578], '(2019)': [1120, 1151, 1183], 'Current': [1121, 2530], 'Landscape': 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'21-May-2019.': [1138], 'Ge': [1139, 1807], 'Z,': [1140, 1675], 'McNamara': [1143], 'dos': [1145], 'Remedios': [1146], 'C': [1147, 1226, 1608, 2018], 'Lal': [1149], 'S': [1150, 1347, 1812, 2535], 'Pathogenesis': [1152], 'pathophysiology': [1154], 'failure': [1157, 1617, 2393], 'reduced': [1159, 1821], 'ejection': [1160], 'fraction:': [1161], 'translation': [1162], 'studies,': [1165], 'Reviews,': [1168, 1627, 2143], '10.1007/s10741-019-09806-0,': [1169], '24:5,': [1170], '(743-758),': [1171], '1-Sep-2019.': [1175], 'Magadum': [1176], 'Kaur': [1178], 'K': [1179, 1965, 2263], 'Zangi': [1181], 'L': [1182, 1250, 1350, 1386, 2048, 2602], 'mRNA-Based': [1184], 'Protein': [1185], 'Replacement': [1186], 'Therapy': [1187, 1977, 2240], 'Heart,': [1190, 1492, 2083], 'Molecular': [1191, 1699, 1729, 1780, 1937, 2101, 2247, 2619], '10.1016/j.ymthe.2018.11.018,': [1193], '27:4,': [1194], '(785-793),': [1195], '1-Apr-2019.': [1199], 'Oh': [1200, 1638, 1662, 1738], 'Watanabe': [1202], 'S,': [1203, 1219, 1272, 1311, 1313, 1454, 1501, 1550, 1667, 1677, 1757, 1808, 2005, 2011, 2259, 2303, 2333, 2372, 2565], 'Lee': [1204, 1208, 1547, 2000], 'Gorski': [1206], 'Jeong': [1210, 1672, 1740], 'D,': [1211, 1343, 1548, 1562, 1597, 1604, 1671, 1673, 1741, 1751, 1761, 1953, 1957, 2121, 2456], 'Liang': [1212, 1214, 1451], 'Baccarini': [1216], 'Sahoo': [1218], 'Brown': [1220], 'R': [1223, 1416, 1456, 1507, 1679, 1765, 1968, 2309, 2427, 2470, 2599], 'Kho': [1225, 1754], '(2018)': [1227, 1254, 1286, 2539], 'miR-146a': [1228], 'Suppresses': [1229], 'SUMO1': [1230], 'Expression': [1231], 'Induces': [1233], 'Cardiac': [1234, 1979, 1991, 2508, 2546], 'Dysfunction': [1235], 'Maladaptive': [1237], 'Hypertrophy,': [1238], 'Circulation': [1239], 'Research,': [1240, 2282, 2531], '123:6,': [1241], '(673-685),': [1242], '31-Aug-2018.': [1246], 'Chemaly': [1247, 2296, 2570], 'Troncone': [1249], 'Lebeche': [1252, 2574], 'D': [1253, 1318, 1510, 1913, 2338, 2538, 2575], 'cell': [1258, 2022], 'death': [1259], 'survival,': [1261], 'Calcium,': [1263], '10.1016/j.ceca.2017.07.001,': [1264], '69,': [1265], '(46-61),': [1266], '1-Jan-2018.': [1270], 'Das': [1271], 'Zhabyeyev': [1273], 'Basu': [1275], 'Patel': [1277], 'Dyck': [1279], 'Kassiri': [1281], 'Z': [1282], 'Oudit': [1284], 'G': [1285, 1481, 1713, 2205], 'Advanced': [1287, 1326], 'iron-overload': [1288], 'cardiomyopathy': [1289, 1878], 'genetic': [1292], 'murine': [1293], 'model': [1294], 'rescued': [1296], 'resveratrol': [1298], 'therapy,': [1299, 1467], 'Bioscience': [1300], 'Reports,': [1301, 1654], '10.1042/BSR20171302,': [1302], '38:1,': [1303], '28-Feb-2018.': [1307], 'Hannah-Shmouni': [1308], 'Seidelmann': [1310], 'Sirrs': [1312], 'Mani': [1314], 'Jacoby': [1317], '(2015)': [1319, 1351, 1390, 2505], 'Genetic': [1321], 'Challenges': [1322], 'Opportunities': [1324], 'Failure,': [1328, 1992, 2525], 'Canadian': [1329], 'Cardiology,': [1332, 1702, 1783, 1883, 1940], '10.1016/j.cjca.2015.07.735,': [1333], '31:11,': [1334], '(1338-1350),': [1335], '1-Nov-2015.': [1339], 'Q,': [1341], 'Su': [1342], "O'Rourke": [1344, 1559], 'Pogwizd': [1346], 'Zhou': [1349, 1541, 2302], 'Mitochondria-derived': [1352], 'ROS': [1353], 'bursts': [1354], 'disturb': [1355], 'Ca': [1356], '2+': [1357], 'cycling': [1358], 'induce': [1360], 'automaticity': [1362], 'guinea': [1364], 'pig': [1365], 'cardiomyocytes:': [1366], 'theoretical': [1368], ',': [1370], 'Physiology-Heart': [1374, 1837, 2036, 2189, 2409], 'Circulatory': [1376, 1839, 2038, 2191, 2411], 'Physiology,': [1377, 1431, 1840, 2039, 2192, 2412, 2514, 2555], '10.1152/ajpheart.00493.2014,': [1378], '308:6,': [1379], '(H623-H636),': [1380], '15-Mar-2015.': [1384], 'Motloch': [1385], 'Akar': [1388, 1412, 1477, 2207], 'F': [1389, 1413, 1478, 1611, 2051, 2076, 2208, 2306, 2424, 2504], 'restore': [1394], 'electrophysiological': [1395], 'failure,': [1399, 1424, 1652], 'Expert': [1400, 2355], 'Opinion': [1401, 2356], 'Biological': [1403, 1522], '10.1517/14712598.2015.1036734,': [1405], '15:6,': [1406], '(803-817),': [1407], '3-Jun-2015.': [1411], '(2014)': [1417], 'therapies': [1419], 'arrhythmias': [1421, 2055], 'Pflügers': [1425], 'Archiv': [1426], '-': [1427], 'European': [1428], '10.1007/s00424-014-1485-3,': [1432], '466:6,': [1433], '(1211-1217),': [1434], '1-Jun-2014.': [1438], 'Merlet': [1439], 'Lipskaia': [1441], 'Marchand': [1443], 'Hadri': [1445, 2562], 'Mougenot': [1447], 'N,': [1448, 1849, 2152, 2154, 2257, 2462], 'Atassi': [1449], 'Hatem': [1453], 'Lompré': [1458], '(2012)': [1460, 1612, 1717, 1769], 'calcium-sensitive': [1462], 'promoter': [1463], 'construct': [1464], '10.1038/gt.2012.30,': [1470], '20:3,': [1471], '(248-254),': [1472], '1-Mar-2013.': [1476, 1709], 'Tomaselli': [1480, 2204], '(2013)': [1482, 1511, 1568, 1640, 1683], 'Electrophysiological': [1483], 'Remodeling': [1484, 2541, 2581], 'Electrical': [1488], 'Diseases': [1489], '10.1007/978-1-4471-4881-4_22,': [1493], '(369-386),': [1494], '.': [1495], 'Schulz': [1496], 'Wilder': [1498], 'Chowdhury': [1500], 'Sheikh': [1502], 'Wolska': [1504, 1915], 'Solaro': [1506, 1910], 'Wieczorek': [1509, 1912], 'Decreasing': [1512], 'Tropomyosin': [1513], 'Phosphorylation': [1514], 'Rescues': [1515], 'Tropomyosin-induced': [1516], 'Familial': [1517], 'Hypertrophic': [1518], 'Cardiomyopathy,': [1519], 'Chemistry,': [1523], '10.1074/jbc.M113.466466,': [1524], '288:40,': [1525], '(28925-28935),': [1526], '1-Oct-2013.': [1530], 'Sivakumaran': [1531], 'Stanley': [1533], 'Tocchetti': [1535], 'C,': [1536, 1753, 1755, 1802, 1853, 1896], 'Ballin': [1537], 'Caceres': [1539], 'Keceli': [1543], 'Rainer': [1545], 'Huke': [1549], 'Ziolo': [1551], 'Kranias': [1553], 'Toscano': [1555], 'Wilson': [1557], 'Kass': [1561], 'Mahaney': [1563], 'Paolocci': [1566], 'N': [1567], 'HNO': [1569], 'Enhances': [1570], 'Activity': [1572], 'Cardiomyocyte': [1574], 'Function': [1575], 'Promoting': [1577], 'Redox-Dependent': [1578], 'Phospholamban': [1579], 'Oligomerization,': [1580], 'Antioxidants': [1581], 'Redox': [1583], 'Signaling,': [1584], '10.1089/ars.2012.5057,': [1585], '19:11,': [1586], '(1185-1197),': [1587], '10-Oct-2013.': [1591], 'Abete': [1592], 'Testa': [1594], 'Della-Morte': [1596], 'Gargiulo': [1598], 'Galizia': [1600], 'de': [1602], 'Santis': [1603], 'Magliocca': [1605], 'Basile': [1607], 'Cacciatore': [1610], 'Treatment': [1613], 'chronic': [1615, 2343], 'elderly:': [1620], 'current': [1621], 'practice': [1622], 'problems,': [1624], '10.1007/s10741-012-9363-6,': [1628], '18:4,': [1629], '(529-551),': [1630], '1-Jul-2013.': [1634], 'Park': [1635, 1674, 1676, 1681, 1752, 1756, 1767], 'W': [1636, 1682, 1768], 'SERCA2a:': [1641], 'prime': [1643], 'target': [1644], 'modulation': [1646], 'during': [1650, 2396, 2485], 'BMB': [1653], '10.5483/BMBRep.2013.46.5.077,': [1655], '46:5,': [1656], '(237-243),': [1657], '31-May-2013.': [1661], 'Kim': [1664, 1744, 1748, 1760, 1762, 2560], 'Jang': [1666], 'Nguen': [1668], 'Yang': [1670, 1750], 'Decoy': [1684], 'peptides': [1685], 'targeted': [1686], 'protein': [1688, 2179], 'phosphatase': [1689, 2180], 'inhibit': [1691], 'dephosphorylation': [1692], 'phospholamban': [1694], 'cardiomyocytes,': [1696, 2032], 'Cellular': [1701, 1727, 1782, 1939], '10.1016/j.yjmcc.2012.12.005,': [1703], '56,': [1704], '(63-71),': [1705], 'Berna-Erro': [1710], 'Woodard': [1712], 'Rosado': [1715], 'Orais': [1718], 'STIMs:': [1720], 'physiological': [1721], 'disease,': [1724], 'Medicine,': [1730, 2224], '10.1111/j.1582-4934.2011.01395.x,': [1731], '16:3,': [1732], '(407-424),': [1733], '1-Mar-2012.': [1737], 'Cha': [1742], 'Lifirsu': [1746], 'Yoo': [1758], 'PICOT': [1770], 'inhibiting': [1775], 'PKCζ': [1776], 'activity,': [1777, 1833, 2405], '10.1016/j.yjmcc.2012.03.005,': [1784], '53:1,': [1785], '(53-63),': [1786], '1-Jul-2012.': [1790], 'Tang': [1791], 'Zhang': [1793, 1805, 2568], 'X,': [1794, 1800], 'Guan': [1797], 'Ai': [1799], 'Szeto': [1801], 'Nakayama': [1803], 'Molkentin': [1809], 'Houser': [1811], 'Chen': [1814], 'X': [1815], '(2010)': [1816, 1859, 1917], 'Enhanced': [1817], 'basal': [1818], 'excitation-contraction': [1822], 'coupling': [1823], 'efficiency': [1824], 'β-adrenergic': [1826], 'reserve': [1827], 'increased': [1831], 'Cav1.2': [1832], '10.1152/ajpheart.00265.2010,': [1841], '299:2,': [1842], '(H519-H528),': [1843], '1-Aug-2010.': [1847], 'Summerfield': [1848], 'Peters': [1850], 'Hercock': [1852], 'Mobasheri': [1854], 'Young': [1857], 'I': [1858, 2272], 'Immunohistochemical': [1860], 'fast-twitch': [1865], 'type': [1866], 'sarco(endo)plasmic': [1867], '(SERCA1)': [1871], 'German': [1873], 'shepherd': [1874], 'dogs': [1875], 'dilated': [1877], 'myocardium,': [1879], 'Veterinary': [1882], '10.1016/j.jvc.2009.12.001,': [1884], '12:1,': [1885], '(17-23),': [1886], '1-Apr-2010.': [1890], 'Peña': [1891], 'Szkudlarek': [1893], 'Warren': [1895], 'Heinrich': [1897], 'Gaffin': [1899], 'Jagatheesan': [1901], 'Goldspink': [1908], 'B': [1916], 'Neonatal': [1918], 'Serca2a': [1922], 'delays': [1923], 'onset': [1924, 2390], 'hypertrophic': [1926, 1933], 'remodeling': [1927, 2215], 'familial': [1932], 'cardiomyopathy,': [1934], '10.1016/j.yjmcc.2010.09.010,': [1941], '49:6,': [1942], '(993-1002),': [1943], '1-Dec-2010.': [1947], 'Jaski': [1948], 'Jessup': [1950], 'Mancini': [1952], 'Cappola': [1954], 'Pauly': [1956], 'Greenberg': [1958], 'Borow': [1960], 'Dittrich': [1962], 'Zsebo': [1964], '(2009)': [1969, 2019, 2052, 2579], 'Calcium': [1970, 2543], 'Upregulation': [1971], 'Percutaneous': [1973], 'Administration': [1974], 'Disease': [1980], '(CUPID': [1981], 'Trial),': [1982], 'First-in-Human': [1984], 'Phase': [1985], '1/2': [1986], 'Clinical': [1987, 2086, 2221], 'Trial,': [1988], '10.1016/j.cardfail.2009.01.013,': [1993], '15:3,': [1994, 2445], '(171-181),': [1995], '1-Apr-2009.': [1999, 2046], 'Stagg': [2002], 'Fukushima': [2004], 'Soppa': [2006], 'Siedlecka': [2008], 'Youssef': [2010], 'Suzuki': [2012], 'Yacoub': [2014], 'M': [2015, 2096, 2233, 2387], 'Adult': [2020], 'progenitor': [2021], 'transplantation': [2023], 'influences': [2024], 'performance': [2026], 'handling': [2029], 'recipient': [2031], '10.1152/ajpheart.00931.2008,': [2040], '296:4,': [2041], '(H927-H936),': [2042], 'Blayney': [2047], 'Lai': [2050], 'Ryanodine': [2053], 'receptor-mediated': [2054], 'sudden': [2057], 'death,': [2059], 'Pharmacology': [2060], 'Therapeutics,': [2062], '10.1016/j.pharmthera.2009.03.006,': [2063], '123:2,': [2064], '(151-177),': [2065], '1-Aug-2009.': [2069], 'JIN': [2070], 'LYON': [2072], 'AKAR': [2075], '(2008)': [2077, 2100, 2135, 2176, 2209, 2237, 2267], 'Arrhythmia': [2078], 'Mechanisms': [2079, 2210], 'Failing': [2082], 'Pacing': [2084], 'Electrophysiology,': [2087], '10.1111/j.1540-8159.2008.01134.x,': [2088], '31:8,': [2089], '(1048-1056),': [2090], '1-Aug-2008.': [2094], 'Janssen': [2098], 'P': [2099], 'Basis': [2102], 'Diastolic': [2104], 'Dysfunction,': [2105], 'Clinics,': [2108], '10.1016/j.hfc.2007.10.007,': [2109], '4:1,': [2110], '(13-21),': [2111], '1-Jan-2008.': [2115], 'Davis': [2116], 'Westfall': [2118], 'Townsend': [2120], 'Blankinship': [2122], 'Herron': [2124, 2260], 'Guerrero-Serna': [2126], 'Wang': [2128], 'W,': [2129, 2170, 2569], 'Devaney': [2130], 'E': [2131, 2335], 'Metzger': [2133, 2265], 'Designing': [2136], 'Performance': [2138], 'Transfer,': [2141], '10.1152/physrev.00039.2007,': [2144], '88:4,': [2145], '(1567-1651),': [2146], '1-Oct-2008.': [2150, 2199], 'Brüchert': [2151], 'Mavila': [2153], 'Boknik': [2155], 'Baba': [2157], 'Fabritz': [2159], 'Gergs': [2161], 'Kirchhefer': [2163], 'Kirchhof': [2165], 'Matus': [2167], 'Schmitz': [2169], 'DePaoli-Roach': [2171], 'Neumann': [2174], 'Inhibitor-2': [2177], 'prevents': [2178], '1-induced': [2181], 'hypertrophy': [2183], 'mortality,': [2185], '10.1152/ajpheart.00515.2008,': [2193], '295:4,': [2194], '(H1539-H1546),': [2195], 'Nass': [2200], 'Aiba': [2202], 'Disease:': [2212], 'ion': [2213], 'channel': [2214], 'ventricle,': [2219], 'Nature': [2220], 'Practice': [2222], '10.1038/ncpcardio1130,': [2225], '5:4,': [2226], '(196-207),': [2227], '1-Apr-2008.': [2231], 'Kalyanasundaram': [2235], 'Failure:': [2243], 'Ready': [2244], 'Primetime?,': [2246], '10.1038/mt.2008.89,': [2249], '16:6,': [2250], '(1002-1004),': [2251], '1-Jun-2008.': [2255], 'Palpant': [2256], 'Day': [2258], 'Converso': [2262], 'Single': [2268], 'histidine-substituted': [2269], 'troponin': [2271], 'confers': [2273], 'protection': [2274], 'age-related': [2276], 'systolic': [2277], 'diastolic': [2279], 'dysfunction,': [2280], '10.1093/cvr/cvn198,': [2283], '80:2,': [2284], '(209-218),': [2285], '1-Nov-2008.,': [2289], '1-Nov-2008.': [2293], 'Palomeque': [2294], 'Colosi': [2298], 'Wellman': [2300], '(2007)': [2310], 'Efficiency': [2311], 'eight': [2313], 'AAV': [2315], 'serotypes': [2316], 'transducing': [2318], 'myocardium': [2320, 2484], 'vivo,': [2322], '10.1038/sj.gt.3302895,': [2325], '14:13,': [2326], '(989-997),': [2327], '1-Jul-2007.': [2331], 'Anker': [2332], 'Jankowska': [2334], 'Okonko': [2337], '(2005)': [2339], 'Therapeutic': [2340, 2358], 'patents': [2341], 'failure:': [2345], 'review': [2347], 'patent': [2349], 'applications': [2350], '1996': [2352], '2002,': [2354], 'Patents,': [2359], '10.1517/13543776.14.5.639,': [2360], '14:5,': [2361], '(639-654),': [2362], '1-May-2004.': [2366], 'Schultz': [2367], 'Glascock': [2369], 'Witt': [2371], 'Nieman': [2373], 'Nattamai': [2375], 'Liu': [2377], 'Lorenz': [2379], 'Shull': [2381], 'Kimball': [2383], 'T': [2384], '(2004)': [2388], 'Accelerated': [2389], 'pressure': [2397], 'overload': [2398], 'chronically': [2400], 'decreased': [2401], 'SERCA2': [2402], '10.1152/ajpheart.00720.2003,': [2413], '286:3,': [2414], '(H1146-H1153),': [2415], '1-Mar-2004.': [2419], 'Bernecker': [2420], 'O,': [2421], '(2003)': [2428, 2475], 'failure—calcium': [2436], 'signaling,': [2437], 'Seminars': [2438], 'Thoracic': [2440], 'Surgery,': [2443], '10.1016/S1043-0679(03)70006-9,': [2444], '(268-276),': [2446], '1-Jul-2003.': [2450], 'Milting': [2451], 'Kassner': [2453], 'Böthig': [2455], 'Thieleczek': [2457], 'Kögler': [2459], 'Teucher': [2461], 'Arusoglu': [2465], 'Minami': [2467], 'Körfer': [2469], 'El': [2472], 'Banayosy': [2473], 'Differential': [2476], 'Ca2+-dependent': [2479], 'ATPase-activity': [2480], 'left': [2482], 'mechanical': [2486], 'circulatory': [2487], 'support,': [2488], 'Lung': [2494], 'Transplantation,': [2495], '10.1016/S1053-2498(02)01218-4,': [2496], '22:11,': [2497], '(1209-1216),': [2498], '1-Nov-2003.': [2502], 'Spinale': [2503], 'Assessment': [2506], 'Function—Basic': [2509], 'Principles': [2510], 'Approaches': [2512], 'Comprehensive': [2513], '10.1002/cphy.c140054,': [2515], '(1911-1946)': [2516], '(2016)': [2517], '2a': [2519], 'Game-Changer': [2522], 'Cardiology': [2528], '10.15406/jccr.2016.05.00181,': [2532], '5:5': [2533], 'Hamilton': [2534], 'Terentyev': [2537], 'Proarrhythmic': [2540], 'Homeostasis': [2544], 'Disease;': [2547], 'Implications': [2548], 'Diabetes': [2550], 'Obesity,': [2552], 'Frontiers': [2553], '10.3389/fphys.2018.01517,': [2556], '9': [2557], 'Karakikes': [2558], 'I,': [2559], 'Sakata': [2564], 'Sun': [2566], 'Leri': [2577], 'Type': [2583], '2': [2584], 'Diabetic': [2585], 'Cardiomyopathy': [2586], 'Its': [2588], 'Phenotypic': [2589], 'Rescue': [2590], 'PLoS': [2593], 'ONE,': [2594], '10.1371/journal.pone.0006474,': [2595], '4:7,': [2596], '(e6474)': [2597], 'Aguayo-Ortiz': [2598], 'Espinoza-Fonseca': [2601], '(2020)': [2603], 'Linking': [2604], 'Biochemical': [2605], 'Structural': [2607], 'States': [2608], 'SERCA:': [2610], 'Achievements,': [2611], 'Challenges,': [2612], 'New': [2614], 'Opportunities,': [2615], 'International': [2616], 'Sciences,': [2620], '10.3390/ijms21114146,': [2621], '21:11,': [2622], '(4146)': [2623], 'June': [2624], '8,': [2625, 2641], '2001Vol': [2626], 'Issue': [2628], '11': [2629], 'Advertisement': [2630, 2645], 'Article': [2631], 'InformationMetrics': [2632], '©': [2633], '2001': [2634, 2642], 'Inc.https://doi.org/10.1161/hh1101.092004': [2638], 'publishedJune': [2640], 'PDF': [2643], 'download': [2644]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028664000', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-09T20:09:08.072879', 'created_date': '2016-06-24'}