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4473, 4485, 4493, 4508, 4534, 4540, 4585, 4599, 4608, 4637, 4653, 4711, 4753, 4833, 4891, 5126, 5150, 5159, 5203, 5237, 5302, 5316, 5325, 5369, 5378, 5386, 5540, 5561, 5615, 5630], 'major': [2, 199, 738, 3115], 'histocompatibility': [3, 200, 395, 403, 739], 'complex': [4, 201, 396, 740], '(MHC)': [5, 202, 397], 'class': [6, 20, 70, 203, 217, 267, 409, 415, 475, 632, 647, 749, 774, 789, 987, 1084, 1129, 1421, 1450, 1923, 2913, 2927, 3155, 3386, 3559, 3696, 3724, 3753, 3772, 3793, 3824, 4041, 4136, 4159, 4222, 4340, 4360, 4374, 4624, 4987, 5254, 5260, 5284, 5307, 5318, 5380, 5392, 5401, 5499], 'II': [7, 71, 204, 268, 416, 476, 648, 775, 988, 1085, 1130, 1422, 1924, 3156, 3560, 3725, 3825, 4137, 4160, 4361, 4375, 4988, 5261, 5285, 5319, 5381, 5402], 'molecules': [8, 109, 205, 306, 417, 477, 776, 989, 1131, 1468, 1868, 2919, 3290, 3942, 4964, 4978, 5256], 'with': [9, 50, 206, 247, 488, 640, 876, 1121, 1453, 1485, 1718, 2499, 2602, 2608, 2812, 3126, 3166, 3300, 3454, 3476, 3607, 3629, 3707, 3729, 3791, 3822, 4129, 4167, 4177, 4459, 5232, 5244, 5279, 5294, 5365, 5497], 'peptides': [10, 207, 991], 'occurs': [11, 208, 5287], 'in': [12, 76, 87, 93, 209, 273, 284, 290, 429, 493, 626, 763, 835, 862, 888, 952, 1061, 1387, 1419, 1602, 1624, 1836, 1872, 1881, 2273, 2385, 2390, 2429, 2461, 2526, 2578, 2772, 2775, 2793, 2856, 2922, 2983, 3016, 3162, 3231, 3270, 3280, 3298, 3332, 3348, 3357, 3383, 3437, 3443, 3469, 3480, 3515, 3539, 3544, 3590, 3596, 3622, 3633, 3758, 3873, 3882, 3904, 3917, 3926, 4073, 4088, 4112, 4127, 4153, 4190, 4277, 4387, 4444, 4457, 4495, 4501, 4529, 4590, 4659, 4662, 4668, 4724, 4786, 4879, 4918, 4965, 5032, 5085, 5095, 5123, 5228, 5239, 5247, 5258, 5274, 5288, 5299, 5322, 5520, 5585, 5591, 5603, 5607, 5636], 'a': [13, 43, 210, 240, 656, 764, 779, 1429, 1575, 2084, 2369, 2462, 2516, 2629, 2640, 2776, 2998, 3008, 3301, 3455, 3506, 3516, 3608, 3659, 3667, 3708, 3745, 3928, 4098, 4278, 4828, 4874, 4916, 5003, 5030, 5200, 5245, 5406, 5408, 5555, 5589], 'series': [14, 211], 'endocytic': [16, 213, 546, 627, 783, 874, 3427, 4566], 'vacuoles,': [17, 214], 'termed': [18, 66, 215, 263, 786, 1210], 'MHC': [19, 69, 216, 266, 474, 646, 748, 773, 986, 1083, 1128, 1420, 1449, 2912, 2926, 3154, 3558, 3695, 3723, 3752, 3771, 3792, 3823, 4040, 4135, 4158, 4339, 4359, 4373, 4623, 4986, 5253, 5259, 5283, 5306, 5317, 5379, 5400, 5498], 'II-enriched': [21, 218, 410, 750, 790], 'compartments': [22, 219], '(MIICs).': [23, 220], 'Morphological': [24, 221], 'criteria': [25, 222], 'have': [26, 223, 1087, 1114, 1344, 1520, 1619, 1827, 2106, 4770, 5081, 5358], 'defined': [27, 224, 5609], 'several': [28, 94, 225, 291, 1588, 3567, 4347, 5196], 'types': [29, 226, 955, 3548, 4094], 'MIICs,': [31, 34, 131, 228, 231, 328, 1062, 3271, 3844, 3899, 4502, 5387], 'including': [32, 97, 229, 294, 1594], 'multivesicular': [33, 120, 162, 230, 317, 359, 950, 1117, 3540, 3568, 3875, 3898, 3906, 4067, 4211, 4234, 4292, 4638], 'which': [35, 232, 486, 534, 985, 2846, 4108, 4125, 4381, 4622, 5198], 'are': [36, 85, 164, 233, 282, 361, 478, 527, 536, 873, 977, 1066, 1379, 1600, 1615, 1636, 2321, 2341, 3343, 3474, 3627, 3789, 4071, 4086, 4175, 4350, 4546, 4630, 4758, 5582, 5623, 5699], 'composed': [37, 234, 479], '50–60-nm': [39, 236], 'vesicles': [40, 58, 160, 237, 255, 357, 879, 914, 1146, 1208, 1511, 1525, 3250, 4636, 5385], 'surrounded': [41, 238], 'by': [42, 193, 239, 390, 653, 661, 1090, 1241, 1281, 1376, 1969, 2228, 2233, 2269, 2411, 2544, 2606, 2650, 2837, 2893, 2902, 2990, 3121, 3253, 3318, 3493, 3646, 3739, 3763, 3801, 3856, 4038, 4480, 4516, 4621, 4714, 4985, 5195, 5313, 5405, 5411], 'limiting': [44, 143, 173, 185, 241, 340, 370, 382, 924, 1134, 3977, 4033, 4064, 4123, 4169, 4204, 4242, 4265, 4300, 4323, 5367, 5538], 'membrane.': [45, 242, 3124, 4170], 'Multivesicular': [46, 243], 'MIICs': [47, 154, 163, 188, 244, 351, 360, 385, 787, 872, 916, 976, 1118, 1137, 1513, 1527, 3044, 3252, 3550, 3569, 3878, 3909, 4070, 4156, 4191, 4238, 4296, 4388, 4549, 4572, 4615, 5289], 'can': [48, 73, 245, 270, 1119, 4616, 4973], 'fuse': [49, 246, 1120], 'the': [51, 60, 88, 116, 125, 142, 150, 172, 175, 182, 248, 257, 285, 313, 322, 339, 347, 369, 372, 379, 489, 494, 530, 539, 545, 629, 641, 769, 947, 981, 1063, 1069, 1122, 1133, 1139, 1144, 1148, 1349, 1441, 1454, 1477, 1502, 1523, 1530, 1578, 1582, 1772, 1863, 2379, 2455, 2458, 2485, 2488, 2822, 2834, 2849, 2909, 2923, 2936, 2939, 2944, 2949, 2969, 2978, 2991, 3118, 3174, 3223, 3234, 3264, 3461, 3470, 3495, 3511, 3614, 3623, 3648, 3664, 3730, 3736, 3759, 3848, 3852, 3866, 3883, 3936, 3956, 3960, 3976, 3985, 4006, 4074, 4081, 4089, 4113, 4122, 4140, 4145, 4148, 4154, 4163, 4168, 4172, 4178, 4193, 4226, 4249, 4260, 4270, 4284, 4307, 4318, 4328, 4342, 4378, 4503, 4506, 4525, 4543, 4561, 4565, 4574, 4586, 4595, 4603, 4611, 4628, 4634, 4651, 4750, 4754, 4889, 4990, 5185, 5235, 5280, 5295, 5300, 5314, 5323, 5366, 5376, 5383, 5388, 5525, 5537, 5558, 5613, 5627, 5646, 5655, 5664, 5673, 5684], 'plasma': [52, 249, 1070, 1123, 1140, 1432, 3001, 3123, 4526, 4575, 4604, 4612, 4991, 5296], 'membrane,': [53, 174, 250, 371, 4605, 5297], 'thereby': [54, 251, 1126], 'releasing': [55, 252, 1143], 'their': [56, 253, 1416, 1470, 2985, 4130, 4591, 4763, 5292, 5595, 5633], 'internal': [57, 117, 151, 159, 183, 254, 314, 348, 356, 380, 877, 913, 1145, 1510, 1524, 3957, 4031, 4062, 4106, 4141, 4164, 4196, 4207, 4240, 4263, 4298, 4321, 4499, 4635, 5384], 'into': [59, 256, 1138, 1147, 3744, 4633, 4839, 5564], 'extracellular': [61, 258], 'space.': [62, 259], 'The': [63, 260, 524, 912, 1206, 1472, 1883, 2168, 2193, 2299, 2522, 2570, 2589, 2787, 2883, 2930, 2956, 3286, 3446, 3482, 3599, 3635, 3749, 3768, 4052, 4244, 4255, 4302, 4313, 4471, 4531, 4619], 'externalized': [64, 261], 'vesicles,': [65, 262, 1080], 'exosomes,': [67, 264, 1603, 2425, 2755, 2984, 4183, 4458, 4486], 'carry': [68, 265], 'and': [72, 92, 102, 136, 145, 184, 269, 289, 299, 333, 342, 381, 483, 542, 565, 604, 814, 848, 880, 886, 1112, 1142, 1274, 1363, 1368, 1423, 1434, 1494, 1514, 1598, 1613, 1632, 1716, 1771, 1776, 1869, 2025, 2102, 2186, 2207, 2271, 2303, 2356, 2397, 2416, 2506, 2546, 2562, 2591, 2596, 2626, 2662, 2779, 2816, 2851, 2887, 2916, 2948, 2954, 2968, 3003, 3043, 3209, 3257, 3275, 3309, 3325, 3345, 3433, 3450, 3457, 3500, 3546, 3557, 3586, 3603, 3610, 3653, 3722, 3756, 3775, 3787, 3835, 3870, 3876, 3890, 3907, 3970, 3990, 4011, 4024, 4032, 4045, 4063, 4068, 4080, 4103, 4184, 4206, 4213, 4235, 4241, 4293, 4299, 4346, 4362, 4376, 4451, 4466, 4498, 4528, 4614, 4627, 4665, 4779, 4843, 5027, 5050, 5119, 5129, 5223, 5263, 5269, 5403, 5515, 5531, 5632, 5678, 5695], 'stimulate': [74, 271], 'T-cells': [75, 272, 427, 1386, 1484, 1835], 'vitro.': [77, 274], 'In': [78, 122, 275, 319, 1076, 1581, 2974, 3261, 3666, 3962, 4116, 4333, 5181, 5249, 5579], 'this': [79, 276, 1592, 2799, 4334, 4715, 4725, 5182, 5544], 'study,': [80, 277, 1584, 4335], 'we': [81, 278, 1111, 1461, 1499, 1585, 3845, 4336, 5207], 'show': [82, 279, 1586, 3340, 4248, 4259, 4306, 4317, 4337, 4873], 'that': [83, 111, 280, 308, 658, 762, 1116, 1463, 1501, 1522, 1587, 3242, 3341, 3719, 3785, 3935, 4338, 4539, 4884, 4976, 5282, 5360, 5373, 5587], 'exosomes': [84, 281, 1211, 1343, 1464, 1826, 1873, 1880, 2827, 2857, 3017, 3189, 3281, 3299, 3317, 3333, 3342, 3698, 3733, 3841, 3918, 4354, 4477, 4494, 5229, 5240, 5303, 5321, 5581, 5631], 'enriched': [86, 283, 1508, 1601, 2384, 2855, 3158, 3192, 3279, 3331, 3347, 3436, 3589, 3916, 4120, 4161, 4351, 4365, 4442, 5273, 5584], 'co-stimulatory': [89, 286, 1459, 1467, 1474, 1503, 1867, 2945, 4343, 5004], 'molecule': [90, 287, 1504, 2941, 2946, 4344, 4830, 5005], 'CD86': [91, 288, 1489, 1505, 3178, 4363], 'tetraspan': [95, 292, 1579, 1870, 3195, 3228, 3349, 3523, 3720, 3816, 3854, 3950, 4007, 4348, 4379, 4447, 4474, 4544, 4554, 4600, 4755, 5233], 'proteins,': [96, 293, 2826, 3966, 4448, 5234, 5529], 'CD37,': [98, 295, 1595, 2951, 4449], 'CD53,': [99, 296, 1596, 3226], 'CD63,': [100, 297, 2952, 4009, 4043, 4380], 'CD81,': [101, 298, 1597, 2953, 3755, 3774, 4010, 4450], 'CD82.': [103, 300, 2955], 'Interestingly,': [104, 301, 3188, 3948, 5488], 'subcellular': [105, 302, 982, 3849], 'localization': [106, 303, 3521, 3850], 'these': [108, 305, 2494, 3338, 3502, 3655, 3827, 3993, 4977], 'revealed': [110, 307, 761, 3865], 'they': [112, 309, 535, 1635, 2496, 2756, 4185, 4569, 4580], 'were': [113, 138, 146, 310, 335, 343, 1209, 2172, 2231, 2267, 2289, 2327, 2409, 2469, 2482, 2497, 2524, 2541, 2552, 2572, 2657, 2757, 2770, 2801, 2810, 2831, 2885, 2891, 2906, 2932, 3190, 3212, 3238, 3277, 3328, 3440, 3452, 3593, 3605, 3742, 3777, 3818, 3952, 3972, 4002, 4035, 4230, 4288, 4364, 4453, 5271, 5533], 'concentrated': [114, 311], 'on': [115, 149, 156, 181, 312, 346, 353, 378, 1348, 1483, 1492, 1509, 1515, 2454, 2554, 2759, 2804, 3249, 3316, 3713, 3826, 3858, 3992, 4030, 4048, 4105, 4121, 4133, 4162, 4181, 4203, 4232, 4239, 4290, 4297, 4352, 4476, 4482, 4490, 4524, 5320], 'membranes': [118, 152, 186, 315, 349, 383, 2492, 2571, 2809, 3728, 3806, 3958, 4034, 4049, 4065, 4143, 4209, 4266, 4324, 4500], 'MIICs.': [121, 318, 3930, 3961, 3980, 3997, 4051, 4115, 4530, 5370, 5541], 'contrast': [123, 320, 3262, 5250], 'to': [124, 141, 166, 190, 321, 338, 363, 387, 425, 529, 544, 778, 860, 946, 979, 1068, 1238, 1385, 1621, 1638, 1830, 2323, 2343, 2564, 2976, 3263, 3504, 3566, 3657, 3727, 3820, 3897, 3945, 3955, 3975, 4264, 4322, 4372, 4384, 4538, 4548, 4564, 4720, 4773, 4881, 4914, 5000, 5028, 5092, 5098, 5155, 5251, 5291, 5375, 5382, 5494, 5536, 5625], 'tetraspans,': [126, 323, 3265, 5197], 'other': [127, 324, 953, 1353, 1495, 1589, 1605, 3266, 3964], 'membrane': [128, 144, 179, 325, 341, 376, 878, 925, 1071, 1124, 1135, 1141, 1433, 1532, 2566, 3002, 3267, 3978, 3994, 4220, 4272, 4330, 4527, 4576, 4613, 4992, 5368, 5528, 5539], 'proteins': [129, 180, 326, 377, 1618, 1871, 2982, 3196, 3268, 3354, 3721, 3817, 3855, 3951, 4008, 4150, 4228, 4286, 4349, 4475, 4545, 4555, 4601, 4756, 5563, 5586], 'such': [132, 329, 1356, 1608, 3967, 5214, 5266, 5611], 'as': [133, 330, 1357, 1609, 1892, 2236, 2324, 2344, 2646, 2665, 2818, 2918, 3007, 3442, 3541, 3543, 3595, 3829, 3968, 4019, 4021, 4165, 4487, 4489, 4827, 4962, 5002, 5215, 5230, 5267, 5554, 5612], 'HLA-DM,': [134, 331, 1612, 2915, 3272, 5524], 'Lamp-1,': [135, 332, 1610, 3274], 'Lamp-2,': [137, 334, 1611, 5532, 5543], 'mainly': [139, 336, 3974, 5363], 'localized': [140, 337, 3895, 5535], 'hardly': [147, 344], 'detectable': [148, 345], 'nor': [155, 352], 'exosomes.': [157, 354, 1445, 1516, 2386, 3795, 4134, 4445, 4509, 4994, 5275], 'Because': [158, 355, 1446, 1825, 3840, 5206], 'thought': [165, 362, 978], 'originate': [167, 364, 918], 'from': [168, 365, 533, 538, 919, 1132, 1277, 1984, 2015, 2050, 2177, 2190, 2200, 2211, 2219, 2484, 2493, 2767, 2833, 2963, 3448, 3601, 3735, 3843, 4560, 5399], 'inward': [169, 366, 920, 4722], 'budding': [170, 367], 'differential': [176, 373, 2234, 2839, 3740, 4187, 4596], 'distribution': [177, 374, 3750], 'has': [189, 386, 4647, 4717, 4783, 4911, 4997, 5089, 5152, 5490, 5551], 'be': [191, 388, 1622, 1831, 3924, 4385, 4514, 4557, 4617, 4774, 4974, 4980, 5093, 5242, 5601], 'driven': [192, 389], 'active': [194, 391], 'protein': [195, 392, 423, 1442, 1533, 2612, 2653, 2961, 3010, 3229, 3487, 3640, 4059, 4188], 'sorting.': [196, 393], 'Major': [394], '1The': [398], 'abbreviations': [399], 'used': [400, 2645], 'are:': [401], 'MHCmajor': [402], 'complexHLAhuman': [404], 'leukocyte': [405, 742], 'antigenIEMimmunoelectron': [406], 'microscopyIiinvariant': [407], 'chainMIICMHC': [408], 'compartmentPAGEpolyacrylamide': [411], 'gel': [412, 753, 2413], 'electrophoresisTfRtransferrin': [413], 'receptor.': [414, 756], 'present': [418, 1583, 3213, 3248, 3538, 3872, 4386], 'peptide': [419, 636, 642, 5264, 5396], 'determinants': [420], 'exogenous': [422], 'antigens': [424], 'CD4+': [426, 4842], '(reviewed': [428], 'Refs.': [430, 592, 836], '1Germain': [431], 'R.N.': [432], 'Margulies': [433], 'D.H.': [434], 'Annu.': [435, 448, 461, 595], 'Rev.': [436, 449, 462, 596], 'Immunol.': [437, 450, 517, 597, 997, 1051, 1304, 1707, 1749, 1783, 1798, 2008, 2043, 2115, 2162, 5044, 5071, 5113, 5142, 5172], '1993;': [438, 971, 998, 1784, 2116, 4740, 5072], '11:': [439, 467], '403-450Crossref': [440], 'PubMed': [441, 454, 469, 507, 521, 560, 584, 601, 616, 674, 692, 715, 809, 829, 907, 940, 1019, 1034, 1102, 1172, 1201, 1232, 1269, 1308, 1335, 1409, 1549, 1570, 1652, 1669, 1687, 1711, 1733, 1766, 1820, 1858, 1915, 1942, 1961, 2078, 2140, 2259, 2684, 2745, 2878, 3038, 3061, 3076, 3101, 3149, 3690, 4403, 4436, 4689, 4707, 4743, 4805, 4822, 4866, 4905, 4930, 4951, 5022, 5075, 5176, 5351, 5424, 5442, 5465, 5574], 'Scopus': [442, 470, 508, 561, 585, 617, 675, 693, 716, 734, 810, 830, 908, 941, 1020, 1035, 1055, 1103, 1173, 1202, 1233, 1251, 1270, 1309, 1336, 1410, 1550, 1571, 1653, 1670, 1688, 1712, 1734, 1767, 1821, 1859, 1916, 1943, 1962, 2079, 2260, 2685, 2700, 2746, 2879, 3039, 3062, 3077, 3102, 3150, 3691, 4404, 4437, 4690, 4744, 4806, 4823, 4867, 4906, 4931, 4952, 5023, 5076, 5177, 5352, 5425, 5443, 5466, 5484, 5575], '(965)': [443], 'Google': [444, 455, 472, 510, 522, 563, 587, 602, 619, 677, 695, 718, 736, 812, 832, 846, 910, 943, 974, 1001, 1022, 1037, 1057, 1105, 1175, 1204, 1235, 1253, 1272, 1311, 1338, 1412, 1552, 1573, 1655, 1672, 1690, 1714, 1736, 1753, 1769, 1787, 1802, 1823, 1861, 1918, 1945, 1964, 2012, 2047, 2081, 2119, 2141, 2166, 2262, 2687, 2702, 2748, 2881, 3041, 3064, 3079, 3104, 3152, 3693, 4406, 4439, 4692, 4708, 4746, 4808, 4825, 4869, 4908, 4933, 4954, 5025, 5048, 5078, 5117, 5146, 5179, 5354, 5427, 5445, 5468, 5486, 5577], 'Scholar,': [445, 456, 511, 678, 696, 719, 1002, 1023, 1038, 1176, 1254, 1312, 1553, 1656, 1673, 1691, 1737, 1788, 1803, 1946, 2120, 2142, 2688, 2703, 2732, 3065, 3080, 4407, 4693, 4809, 4934, 5428, 5446, 5469], '2Cresswell': [446, 593], 'P.': [447, 502, 515, 573, 594, 606, 666, 700, 933, 1643, 1679, 1725, 1757, 2017, 2052, 4423, 5416, 5450, 5517, 5660, 5680], '1994;': [451, 598, 843, 937, 1016, 1031, 1649, 1763, 3073], '12:': [452, 599], '259-293Crossref': [453, 600], '3Wolf': [457], 'P.R.': [458], 'Ploegh': [459, 800, 821, 1541, 1933, 1953, 1973, 4395, 5643], 'H.L.': [460, 801, 822, 1542, 1934, 1954, 4396], 'Cell': [463, 841, 902, 935, 969, 1014, 1097, 1196, 1246, 1565, 2279, 2679, 2740, 3056, 4738, 5070, 5171], 'Dev.': [464], 'Biol.': [465, 725, 842, 903, 936, 970, 1015, 1098, 1197, 1247, 1566, 1664, 2680, 2741, 3057, 4699, 4739, 5018, 5475], '1995;': [466, 668, 686, 712, 1799, 2009, 2044, 4433, 5019, 5045, 5418, 5436, 5462], '267-306Crossref': [468], '(252)': [471], 'Scholar).': [473, 523, 620, 737, 871, 911, 975, 1058, 1106, 1205, 1339, 1413, 1824, 1919, 2167, 2263, 2749, 2882, 3105, 4709, 4747, 4870, 4909, 4955, 5079, 5147, 5180, 5355, 5487, 5522, 5578], 'an': [481, 1108, 1876, 3700], 'α': [482], 'β': [484], 'subunit,': [485], 'associate': [487, 5495], 'invariant': [490, 634, 746, 5394], 'chain': [491, 635, 747, 5395], '(Ii)': [492], 'endoplasmic': [495], 'reticulum': [496], '(4Roche': [497], 'P.A.': [498, 1557, 1998, 2675, 5162], 'Marks': [499], 'M.S.': [500], 'Cresswell': [501, 514, 572, 665, 932, 5415], 'Nature.': [503, 711, 825, 1030, 1545, 1957, 3072, 4399, 5461], '1991;': [504, 581, 826, 1248, 1266, 1332, 1546, 1958, 4400, 4701], '354:': [505], '392-394Crossref': [506], '(307)': [509], '5Lamb': [512], 'C.A.': [513, 567, 4695], 'J.': [516, 723, 840, 896, 901, 934, 968, 996, 1013, 1050, 1096, 1166, 1188, 1195, 1226, 1263, 1301, 1303, 1316, 1324, 1329, 1366, 1370, 1403, 1564, 1706, 1748, 1782, 1797, 1814, 1852, 1909, 2007, 2042, 2068, 2088, 2114, 2135, 2161, 2253, 2678, 2872, 3032, 3050, 3055, 3095, 3143, 3684, 4430, 4679, 4698, 4732, 4737, 4799, 4899, 4924, 4945, 5016, 5043, 5063, 5112, 5141, 5345, 5473, 5510, 5514, 5518, 5670], '1992;': [518, 1099, 2137, 2163], '148:': [519], '3478-3482Crossref': [520], 'αβIi': [525], 'complexes': [526, 1065, 1452, 1641, 5501], 'transported': [528, 1067, 4547], 'trans-Golgi': [531, 4562], 'network,': [532], 'diverged': [537], 'secretory': [540], 'pathway': [541, 547], 'targeted': [543, 4558], '(Refs.': [548], '6Bakke': [549], 'O.': [550, 1322, 1781, 1796, 2113, 2134, 2160], 'Dobberstein': [551], 'B.': [552, 958], 'Cell.': [553, 607, 667, 802, 1264, 1665, 1935, 4682, 5417], '1990;': [554, 803, 1936, 4683, 5114, 5143], '63:': [555], '707-716Abstract': [556], 'Full': [557, 611, 613, 671, 689, 729, 731, 806, 1939, 2073, 2075, 4686, 4704, 4861, 4863, 5421, 5439, 5479, 5481], 'Text': [558, 612, 614, 672, 690, 730, 732, 807, 1940, 2074, 2076, 4687, 4705, 4862, 4864, 5422, 5440, 5480, 5482], 'PDF': [559, 615, 673, 691, 733, 808, 1941, 2077, 4688, 4706, 4865, 5423, 5441, 5483], '(554)': [562], 'Scholar': [564, 603, 813, 847], '7Lamb': [566], 'Yewdell': [568], 'J.W.': [569, 1293, 1326, 1559, 2671, 2690, 2711, 2738], 'Bennink': [570], 'J.R.': [571, 2033, 4938], 'Proc.': [574], 'Natl.': [575], 'Acad.': [576], 'Sci.': [577], 'U.': [578], 'S.': [579, 894, 1040, 1192, 1561, 2130, 2148, 3048, 4671, 4730, 4898, 5009, 5036, 5134, 5138], 'A.': [580, 1008, 1190, 1258, 1986, 2018, 4677, 4734, 4856, 5168, 5651, 5661], '88:': [582], '5998-6002Crossref': [583], '(151)': [586], 'Scholar;': [588, 833], 'for': [589, 1415, 1431, 2276, 2291, 2305, 2335, 2350, 2362, 2399, 2471, 2508, 2534, 2575, 2599, 2619, 2659, 2781, 2908, 2935, 2995, 3193, 3241, 3458, 3510, 3535, 3611, 3663, 3831, 4005, 4022, 4057, 4225, 4269, 4283, 4327, 4650, 4776, 4888, 4982, 5006, 5557, 5644, 5654, 5663, 5672, 5683, 5702], 'reviews,': [590], 'see': [591], '8Cresswell': [605], '1996;': [608, 726, 1052, 1169, 1198, 1229, 1406, 1567, 1666, 1684, 1708, 1730, 1750, 1817, 1855, 1912, 2070, 2256, 2742, 2875, 3035, 3098, 3146, 3687, 4802, 4819, 5348, 5476, 5571], '84:': [609], '505-507Abstract': [610], '(295)': [618], 'After': [621], 'proteolytic': [622], 'processing': [623, 5286], 'Ii': [625, 2917, 5389], 'compartments,': [628, 784], 'Ii-degradation': [630], 'product': [631, 5391], 'II-associated': [633, 5393], 'remains': [637], 'temporarily': [638], 'associated': [639, 3790, 5364], 'binding': [643], 'groove': [644], 'but': [649, 3879, 3922], 'is': [650, 659, 1438, 1506, 3467, 3537, 3620, 3934, 4126, 4144, 4157, 4382, 4550, 4640, 4886, 4968, 5121, 5277, 5362, 5397, 5546], 'ultimately': [651], 'displaced': [652], 'antigenic': [654], 'peptides,': [655], 'process': [657, 4726, 5409], 'catalyzed': [660, 5410], 'HLA-DM': [662, 5268, 5361, 5412], '(9Denzin': [663, 5413], 'L.K.': [664, 5414], '82:': [669, 5419], '155-166Abstract': [670, 5420], '(635)': [676, 5426], '10Sherman': [679, 5429], 'M.A.': [680, 1025, 3067, 4413, 5430], 'Weber': [681, 5431], 'D.A.': [682, 5432], 'Jensen': [683, 5433], 'P.E.': [684, 5434], 'Immunity.': [685, 2069, 4857, 5435], '3:': [687, 5437], '197-205Abstract': [688, 5438], '(313)': [694, 5444], '11Sloan': [697, 5447], 'V.S.': [698, 5448], 'Cameron': [699, 5449], 'Porter': [701, 5451], 'G.': [702, 852, 1042, 1153, 1213, 1390, 1839, 1896, 2240, 2654, 2705, 2709, 2859, 3019, 3082, 3130, 3671, 4675, 5332, 5452], 'Gammon': [703, 5453], 'M.': [704, 706, 1180, 1320, 1660, 1700, 1792, 1794, 2124, 2128, 2150, 2152, 2156, 4421, 4813, 4942, 5454, 5456, 5692, 5696], 'Amaya': [705, 5455], 'Mellins': [707, 5457], 'E.': [708, 1693, 2037, 5170, 5458], 'Zaller': [709, 5459], 'D.M.': [710, 2717, 5460], '375:': [713, 5463], '802-806Crossref': [714, 5464], '(510)': [717, 5467], '12Sanderson': [720, 5470], 'F.': [721, 1658, 1696, 1741, 2062, 5471], 'Trowsdale': [722, 2067, 2089, 5472, 5671], 'Curr.': [724, 5474], '5:': [727, 5477], '1372-1376Abstract': [728, 5478], '(14)': [735, 5485], 'human': [741, 1885], 'antigen': [743, 1383, 1625, 3384, 4983, 5592], 'immunoelectron': [744, 2751], 'microscopy': [745, 758], 'compartment': [751], 'polyacrylamide': [752], 'electrophoresis': [754, 2414], 'transferrin': [755, 1426], 'Immunoelectron': [757], '(IEM)': [759], 'studies': [760, 1519, 5357], 'variety': [765], 'antigen-presenting': [767, 1354, 1496], 'cells,': [768, 1355, 1359, 2380], 'majority': [770], 'intracellular': [772, 3868, 3940], 'localize': [777, 3726], 'heterogeneous': [780], 'set': [781], 'collectively': [785], '(MHC': [788], 'compartments)': [791], '(Refs.13Neefjes': [792], 'J.J.': [793, 818, 856, 1194, 1538, 1926, 1950, 2066, 4392], 'Stollorz': [794, 1927], 'V.': [795, 820, 1318, 1540, 1647, 1761, 1928, 1952, 4394], 'Peters': [796, 1929], 'P.J.': [797, 816, 1285, 1314, 1536, 1930, 1948, 4390], 'Geuze': [798, 823, 853, 899, 930, 994, 1045, 1094, 1164, 1224, 1286, 1327, 1401, 1543, 1562, 1850, 1907, 1931, 1955, 2251, 2691, 2712, 2735, 2870, 3030, 3053, 3093, 3141, 3682, 4397, 4426, 5343], 'H.J.': [799, 824, 838, 854, 900, 931, 995, 1046, 1095, 1165, 1225, 1287, 1328, 1402, 1544, 1563, 1851, 1908, 1932, 1956, 2252, 2669, 2692, 2713, 2736, 2871, 3031, 3054, 3094, 3142, 3683, 4398, 4427, 5344], '61:': [804, 972, 1937, 4684], '171-183Abstract': [805, 1938], '(417)': [811, 1944], '14Peters': [815, 1947], 'Neefjes': [817, 1193, 1537, 1949, 2065, 4391], 'Oorschot': [819, 1317, 1539, 1951, 4393, 4414], '349:': [827, 1547, 1959, 4401], '669-676Crossref': [828, 1548, 1960, 4402], '(604)': [831, 1551, 1963, 4405], 'reviewed': [834], '15Geuze': [837], 'Eur.': [839, 967, 1049, 1302, 1705], '64:': [844], '3-6PubMed': [845], '16Kleijmeer': [849], 'M.J.': [850, 892, 1044, 2707, 3046, 4411, 5109], 'Raposo': [851, 1041], 'Langone': [855], 'Methods:': [857], 'A': [858, 2441, 3308, 3931, 3983, 4644], 'Companion': [859], 'Methods': [861, 2695], 'Enzymology.': [863], 'Academic': [864], 'Press,': [865], 'Inc.,': [866, 2374, 2729], 'San': [867, 2616], 'Diego,': [868, 2214], 'CA1996:': [869], '191-207Google': [870], 'vacuoles': [875], 'sheets,': [881], 'reminiscent': [882], 'late': [884], 'endosomes': [885], 'lysosomes': [887, 4669, 5565], 'non-antigen-presenting': [889], 'cells': [890, 2266, 2288, 2656, 2850, 3168, 5100, 5193], '(17Kleijmeer': [891, 3045], 'Morkowski': [893, 3047], 'Griffith': [895, 1294, 3049], 'Rudensky': [897, 1047, 3051], 'A.Y.': [898, 1048, 3052], '1997;': [904, 3058, 4858, 4902, 5173], '139:': [905, 3059], '639-649Crossref': [906, 3060], '(198)': [909, 1252, 3063], 'probably': [917], 'vesiculation': [921, 4723], 'its': [923, 3013, 4522, 4663], '(18Riberdy': [926], 'J.M.': [927, 1027, 1295, 3069], 'Avva': [928], 'R.R.': [929], '125:': [938, 1017], '1225-1237Crossref': [939], '(79)': [942, 4824], 'Scholar),': [944, 1236, 1574, 1754, 1770, 1862, 3153, 3694, 4440, 5118], 'analogous': [945, 1237], 'formation': [948, 2924, 4194], 'bodies': [951, 4639], 'cell': [954, 1149, 1350, 5086, 5124, 5131, 5204], '(19Van': [956], 'Deurs': [957], 'Holm': [959], 'P.K.': [960], 'Kayser': [961], 'L.': [962, 1182, 1809, 1972, 1987, 2053, 4794, 5061, 5164, 5505, 5642, 5652, 5681], 'Sandvig': [963], 'K.': [964, 1262, 2122, 2146, 4673, 5057, 5697], 'Hansen': [965], 'S.H.': [966], '208-224PubMed': [973], 'represent': [980], 'site': [983], 'at': [984, 1469, 2294, 2308, 2330, 2347, 2358, 2402, 2474, 2511, 2531, 2784, 3710, 3808, 4602, 4989], 'bind': [990], '(20Harding': [992], 'C.V.': [993, 1093, 1161, 1221, 1398, 1847, 1904, 2248, 2867, 3027, 3090, 3138, 3679, 5340], '151:': [999, 1785, 2117], '3988-3998PubMed': [1000], '21Qiu': [1003], 'Y.': [1004, 2132, 2158, 5053], 'Xu': [1005], 'X.': [1006], 'Wandiger-Ness': [1007], 'Dalke': [1009], 'D.P.': [1010], 'Pierce': [1011], 'S.K.': [1012, 1743], '595-605Crossref': [1018], '(223)': [1021], '22West': [1024, 3066], 'Lucocq': [1026, 3068], 'Watts': [1028, 3070], 'C.': [1029, 1698, 1704, 2064, 2721, 3071, 4736, 5011, 5038, 5069, 5136, 5693], '369:': [1032, 3074], '147-151Crossref': [1033, 3075], '(344)': [1036, 3078], '23Morkowski': [1039], 'Kleijmeer': [1043, 1367, 2706, 4410], '27:': [1053], '609-617Crossref': [1054], '(15)': [1056], 'Once': [1059], 'formed': [1060], 'αβ-peptide': [1064], 'via': [1072, 4573], 'largely': [1073, 3953, 4759], 'unidentified': [1074], 'pathways.': [1075], 'macrophages,': [1077], 'putative': [1078], 'transport': [1079, 4609, 5262], 'containing': [1081, 1342, 2283, 2580], 'peptide-loaded': [1082, 5305], 'molecules,': [1086, 5213], 'been': [1088, 1346, 1828, 2107, 4648, 4718, 4771, 4784, 4912, 4998, 5083, 5090, 5153, 5492, 5552], 'described': [1089, 1893, 2108, 2237, 2666, 4649, 4772, 5553], 'IEM': [1091, 1518, 3254, 3319, 3803, 3857, 4173, 4481, 4520, 5356], '(24Harding': [1092], '119:': [1100], '531-542Crossref': [1101], '(144)': [1104, 2080], 'As': [1107], 'alternative': [1109], 'pathway,': [1110], 'others': [1113], 'shown': [1115, 1521, 1620, 1829, 3468, 3621, 5091, 5154, 5359, 5493], 'directly,': [1125], 'inserting': [1127], 'culture': [1150, 2835, 3737], 'medium': [1151, 2275, 3738], '(25Raposo': [1152, 1212, 1389, 1838, 1895, 2239, 2858, 3018, 3129, 3670], 'Nijman': [1154, 1214, 1391, 1840, 1897, 2241, 2860, 3020, 3083, 3131, 3672, 5333], 'H.W.': [1155, 1215, 1392, 1841, 1898, 2242, 2861, 3021, 3084, 3132, 3673, 4409, 5334], 'Stoorvogel': [1156, 1216, 1393, 1842, 1899, 2243, 2862, 3022, 3085, 3133, 3674, 5335], 'W.': [1157, 1217, 1394, 1843, 1900, 2244, 2734, 2863, 3023, 3086, 3134, 3675, 5336], 'Leijendekker': [1158, 1218, 1395, 1844, 1901, 2245, 2864, 3024, 3087, 3135, 3676, 5337], 'R.': [1159, 1178, 1219, 1396, 1845, 1902, 2039, 2246, 2865, 3025, 3088, 3136, 3677, 4811, 4848, 5140, 5338, 5691], 'Harding': [1160, 1220, 1397, 1846, 1903, 2247, 2866, 3026, 3089, 3137, 3678, 5339], 'Melief': [1162, 1222, 1399, 1848, 1905, 2249, 2868, 3028, 3091, 3139, 3680, 4428, 5341], 'C.J.M.': [1163, 1223, 1400, 1849, 1906, 2250, 2869, 3029, 3092, 3140, 3681, 4429, 5342], 'Exp.': [1167, 1227, 1330, 1404, 1815, 1853, 1910, 2254, 2873, 3033, 3096, 3144, 3685, 4431, 4800, 4900, 4925, 4946, 5346], 'Med.': [1168, 1228, 1331, 1405, 1816, 1854, 1911, 2255, 2874, 3034, 3097, 3145, 3686, 4432, 4801, 4901, 4926, 4947, 5347], '183:': [1170, 1230, 1407, 1856, 1913, 2257, 2876, 3036, 3099, 3147, 3688, 5349], '1161-1172Crossref': [1171, 1231, 1408, 1857, 1914, 2258, 2877, 3037, 3100, 3148, 3689, 5350], '(2637)': [1174, 1234, 1411, 1860, 1917, 2261, 2880, 3040, 3103, 3151, 3692, 5353], '26Wubbolts': [1177], 'Fernandez-Borja': [1179], 'Oomen': [1181], 'Verwoerd': [1183], 'D.': [1184, 5013, 5040], 'Janssen': [1185], 'H.': [1186, 1369, 1702, 1971, 5015, 5042, 5513, 5641], 'Calafat': [1187], 'Tulp': [1189], 'Dusseljee': [1191], '135:': [1199], '611-622Crossref': [1200], '(185)': [1203], 'released': [1207, 1240, 1280], 'those': [1239, 1275], 'reticulocytes': [1242], '(27Johnstone': [1243], 'R.M.': [1244, 1256], 'Biochem.': [1245, 1680, 1726], '70:': [1249], '179-190Crossref': [1250], '28Johnstone': [1255], 'Mathew': [1257], 'Mason': [1259], 'A.B.': [1260], 'Teng': [1261], 'Physiol.': [1265], '147:': [1267], '27-36Crossref': [1268], '(229)': [1271], 'Scholar)': [1273, 1715, 1965, 2013, 2048, 2082, 3042, 4826, 5026, 5049], 'originating': [1276], 'cytolytic': [1278], 'granules': [1279], 'cytotoxic': [1282], 'T-lymphocytes': [1283], '(29Peters': [1284], 'Van': [1288, 2672, 4418, 5103], 'der': [1289, 2673], 'Donk': [1290], 'H.A.': [1291], 'Slot': [1292, 1325, 1558, 2670, 2710, 2737], 'Stam': [1296], 'N.J.': [1297], 'Clevers': [1298], 'H.C.': [1299], 'Borst': [1300, 1315], '1989;': [1305], '19:': [1306], '1469-1475Crossref': [1307], '(204)': [1310], '30Peters': [1313], 'Fukuda': [1319], 'Krähenbühl': [1321], 'Tschopp': [1323], '173:': [1333], '1099-1109Crossref': [1334], '(553)': [1337], 'Exocytic': [1340], 'profiles': [1341, 4001, 4497], 'also': [1345, 1528, 2933, 3292, 3314, 4641, 5082], 'found': [1347, 3269, 3819, 3903, 3925, 4060, 5208], 'surface': [1351], 'dendritic': [1358], 'tonsil': [1360], 'B-cells,': [1361], 'monocytes,': [1362], 'macrophages.': [1364], '2M.': [1365], 'Geuze,': [1371, 5512], 'unpublished': [1372], 'data.': [1373], 'Exosomes': [1374, 2230, 3998], 'secreted': [1375], 'B-cell': [1377, 1886], 'lines': [1378, 5132], 'capable': [1380, 1832], 'effective': [1382], 'presentation': [1384, 4984], 'vitro': [1388, 1837, 4846], 'Except': [1414], 'relative': [1417, 2957, 2979, 3175, 3483, 3636, 4460], 'enrichment': [1418, 2980, 3176, 3303, 3352, 3484, 3637, 4100, 4461], 'depletion': [1424], 'receptor': [1427, 1456, 4658, 4716, 5556], '(TfR),': [1428], 'marker': [1430, 2999], 'early': [1435, 3004, 4876], 'endosomes,': [1436, 3005, 4660], 'little': [1437, 3110, 5210], 'known': [1439, 4383], 'about': [1440, 2284], 'composition': [1443], 'interaction': [1447, 1478], 'II-peptide': [1451, 2928], 'T-cell': [1455, 1627, 1629, 1773, 4777, 4780, 4787, 5604, 5616, 5619], 'requires': [1457], 'appropriate': [1458], 'signals,': [1460], 'anticipated': [1462], 'might': [1465], 'express': [1466], 'surface.': [1471], 'main': [1473], 'pathways': [1475], 'involve': [1476], 'CD28': [1480], 'or': [1481, 1488, 2392, 2557, 2898, 5618], 'CTLA-4': [1482], 'CD80': [1486], '(B7.1)': [1487], '(B7.2)': [1490], 'expressed': [1491, 3230], 'B-cells': [1493, 2830, 5160], 'cells.': [1497, 3532, 3863], 'Here': [1498], 'report': [1500], 'strongly': [1507, 3915, 4003], 'Previous': [1517], 'contain': [1529, 4583], 'lysosomal': [1531, 3965, 5527], 'CD63': [1534, 3901, 3989, 4102, 5088], '(14Peters': [1535, 4389], '31Glickman': [1554], 'J.N.': [1555], 'Morton': [1556, 2019, 5662], 'Kornfeld': [1560], '132:': [1568], '769-785Crossref': [1569], '(59)': [1572], 'member': [1576], 'superfamily.': [1580], 'members': [1590], 'family,': [1593], 'CD82,': [1599, 4044, 4452], 'whereas': [1604, 2381, 3900], 'MIIC': [1606, 4142], 'markers,': [1607], 'Ii,': [1614, 3273, 5270], 'not.': [1616], 'Tetraspan': [1617], 'involved': [1623, 2921, 3382, 5094, 5122, 5257, 5602], 'presentation,': [1626, 5593], 'signaling,': [1628], 'activation,': [1630], 'motility,': [1631], 'adhesion.': [1633, 5087, 5248], 'Also,': [1634], 'able': [1637], 'form': [1639, 5202], 'oligomeric': [1640], '(32Angelisova': [1642, 1756], 'Hilgert': [1644, 1758], 'I.': [1645, 1759], 'Horejsi': [1646, 1760], 'Immunogenetics.': [1648, 1762], '39:': [1650, 1764], '249-256Crossref': [1651, 1765], '(172)': [1654, 1768], '33Berditchesvski': [1657], 'Zutter': [1659], 'Hemler': [1661, 1746], 'M.E.': [1662, 1747], 'Mol.': [1663], '7:': [1667], '193-207Crossref': [1668], '(251)': [1671], '34Radford': [1674], 'K.J.': [1675, 1721], 'Thorne': [1676, 1722], 'R.F.': [1677, 1723], 'Hersey': [1678, 1724], 'Biophys.': [1681, 1727], 'Res.': [1682, 1728], 'Commun.': [1683, 1729], '222:': [1685, 1731], '13-18Crossref': [1686, 1732], '(86)': [1689, 1735], '35Rubinstein': [1692], 'Le': [1694], 'Naour': [1695], 'Lagaudrière-Gesbert': [1697], 'Billard': [1699], 'Conjeaud': [1701, 5014, 5041], 'Boucheix': [1703], '26:': [1709], '2657-2665Crossref': [1710], '(334)': [1713], 'interact': [1717], 'integrins': [1719], '(34Radford': [1720], '36Mannion': [1738], 'B.A.': [1739], 'Berditchevski': [1740], 'Kraeft': [1742], 'Chen': [1744], 'L.B.': [1745], '157:': [1751], '2039-2047PubMed': [1752], 'HLA-DR': [1755], 'co-receptors': [1774], 'CD4': [1775], 'CD8': [1777], '(37Imai': [1778, 2110], 'T.': [1779, 1790, 2111, 2126, 2144, 5055, 5059, 5688], 'Yoshie': [1780, 1795, 2112, 2133, 2159], '6470-6481PubMed': [1786, 2118], '38Imai': [1789], 'Kakizaki': [1791], 'Nishimura': [1793, 2127, 2155], '155:': [1800, 2045, 5046], '1229-1239PubMed': [1801], '39Todd': [1804], 'S.C.': [1805, 4790], 'Lipps': [1806, 4791], 'S.G.': [1807, 4792], 'Crisa': [1808, 4793], 'Salomon': [1810, 4795], 'D.R.': [1811, 4796], 'Tsoukas': [1812, 4797], 'C.D.': [1813, 4798], '184:': [1818, 4803], '2055-2060Crossref': [1819, 4804], '(84)': [1822, 4807], 'stimulating': [1834], 'selective': [1864, 5559], 'incorporation': [1865], 'further': [1874, 2422, 3783, 3799, 4036], 'supports': [1875], 'immunostimulatory': [1877], 'role': [1878, 4917, 5031, 5246, 5590, 5629], 'vivo.': [1882, 5598], 'EBV-transformed': [1884], 'line': [1887], 'RN': [1888, 2265, 2655, 2829, 3531, 3862], '(HLA-DR15+)': [1889], 'was': [1890, 1966, 1983, 2014, 2049, 2083, 2226, 2301, 2315, 2383, 2427, 2452, 2624, 2644, 2790, 2853, 2966, 2972, 2988, 3157, 3181, 3246, 3291, 3296, 3313, 3490, 3643, 3761, 3798, 3871, 3902, 3914, 4109, 4119, 4441, 4478, 4536, 5311], 'maintained': [1891], 'earlier': [1894], 'Rabbit': [1920, 1980], 'polyclonal': [1921, 1981, 1994, 2026, 2641, 5648, 5657, 5666, 5686], 'anti-MHC': [1922], '(13Neefjes': [1925], 'generously': [1967], 'provided': [1968], 'Dr.': [1970, 1985, 2016, 2051, 2087, 5640, 5650, 5659, 5669, 5679], '(Massachusetts': [1974], 'Institute': [1975], 'Technology,': [1977], 'Cambridge,': [1978], 'MA).': [1979, 2569], 'anti-TfR': [1982, 5656], 'Schwartz': [1988, 2005, 5653], '(Washington': [1989], 'University,': [1990], 'St.': [1991, 2022], 'Louis,': [1992, 2023], 'MO),': [1993, 2024], 'anti-Ii': [1995, 5665], '(ICN-1)': [1996], '(40Morton': [1997], 'Zacheis': [1999], 'M.L.': [2000], 'Giacoletto': [2001], 'K.S.': [2002, 4852], 'Manning': [2003], 'J.A.': [2004, 4850, 5105], 'B.D.': [2006], '154:': [2010], '137-150PubMed': [2011], '(Monsanto': [2020], 'Co.,': [2021], 'anti-ICAM-1': [2027, 5685], '(CD54)': [2028, 3295], '(41Reilly': [2029], 'P.L.': [2030], 'Woska': [2031], 'Jr.,': [2032], 'Jeanfavre': [2034], 'D.D.': [2035], 'McNally': [2036], 'Rothlein': [2038], 'Bormannn': [2040], 'B.J.': [2041], '529-532PubMed': [2046], 'Reilly': [2054, 5682], '(Boehringer': [2055], 'Mannheim).': [2056], 'Monoclonal': [2057, 2097], 'antibody': [2058, 2225, 2643, 2648, 3938, 4877, 5667, 5676], '5C1': [2059], '(HLA-DM)': [2060], '(42Sanderson': [2061], 'Thomas': [2063], '4:': [2071], '87-96Abstract': [2072], 'gift': [2085], '(Imperial': [2090], 'Cancer': [2091], 'Research': [2092], 'Fund,': [2093], 'London,': [2094], 'United': [2095], 'Kingdom).': [2096], 'antibodies': [2098, 2171, 2604, 3237], 'M38': [2099], '(IgG1;': [2100, 2175, 2184, 2188, 2196, 2205, 2209, 2217], 'CD81)': [2101], 'C33': [2103], '(IgG2a;': [2104], 'CD82)': [2105], 'previously': [2109, 2238, 2667], '43Fukudome': [2121], 'Furuse': [2123, 2151], 'Imai': [2125], 'Takagi': [2129, 2147], 'Hinuma': [2131, 2157], 'Virol.': [2136], '66:': [2138], '1394-1401Crossref': [2139], '44Imai': [2143], 'Fukudome': [2145], 'Nagira': [2149], 'Fukuhara': [2153], 'N.': [2154], '149:': [2164], '2879-2886PubMed': [2165], 'following': [2169], 'monoclonal': [2170, 2638, 5675], 'purchased:': [2173], 'BU63': [2174], 'CD86)': [2176], 'Ancell': [2178], 'Europe': [2179], '(Läufelfingen,': [2180], 'Switzerland),': [2181], 'CLB-gran1/2,': [2182], '435': [2183], 'CD63),': [2185], 'MEM-53': [2187], 'CD53)': [2189], 'CLB': [2191], '(Amsterdam,': [2192], 'Netherlands);': [2194], 'CR3/43': [2195], 'HLA-DP,': [2197], '-DQ,': [2198], '-DR)': [2199], 'DAKO': [2201], '(Glostrup,': [2202], 'Denmark);': [2203], 'H4A3': [2204], 'CD107a)': [2206], 'H4B4': [2208], 'CD107b)': [2210], 'Pharmingen': [2212], '(San': [2213], 'CA);': [2215], 'S-B3': [2216], 'CD37)': [2218], 'Sanofi': [2220], '(Montpellier,': [2221], 'France).': [2222], 'Polyclonal': [2223], 'anti-IgG': [2224, 2642], 'supplied': [2227], 'DAKO.': [2229], 'isolated': [2232, 3734, 4182, 4353], 'centrifugation': [2235, 2270, 3741], 'Briefly,': [2264], 'washed': [2268], 'recultured': [2272], 'fresh': [2274], '18': [2277], 'h.': [2278], 'cultures': [2280], '(35': [2281], 'ml)': [2282], '5': [2285, 2400, 2430], '×': [2286, 2310, 2332, 2360, 2476, 2513], '107': [2287], 'centrifuged': [2290, 2304, 2329, 2470, 2507], '10': [2292, 2306], 'min': [2293, 2307, 2337, 2352, 2364, 2401, 2510, 2577, 2601, 2783], '200': [2295, 3574], '×g': [2296, 2349], '(pellet': [2297, 2312], 'P1).': [2298], 'supernatant': [2300], 'removed': [2302, 5398], '500': [2309], 'g': [2311, 2333, 2361, 2514], 'P2).': [2313, 2325], 'This': [2314, 3796, 5276, 5309, 5371], 'repeated': [2316], 'once': [2317, 2346, 2357], '(the': [2318, 2338], 'pooled': [2319, 2339, 2774], 'pellets': [2320, 2340, 2523, 2766, 2843, 2884, 2931, 3439, 3592], 'referred': [2322, 2342], 'Supernatants': [2326], 'sequentially': [2328], '2,000': [2331], 'twice': [2334], '15': [2336, 2472], 'P3),': [2345], '10,000': [2348], '30': [2351], '(yielding': [2353, 2365], 'pellet': [2354, 2366, 2408, 2789], 'P4)': [2355], '70,000': [2359, 2785], '60': [2363, 2509, 2535, 2782], 'P5),': [2367], 'using': [2368, 2515, 2628], 'SW27': [2370, 2463, 2777], 'rotor': [2371, 2518], '(Beckman': [2372, 2465, 2519], 'Instruments,': [2373, 2466, 2520], 'Fullerton,': [2375], 'CA).': [2376, 2634], 'P1': [2377, 2847, 3449, 3584, 3602], 'contained': [2378, 2848, 3109], 'P5': [2382, 2426, 2852, 2965, 3434, 3451, 3587, 3604], 'P1–P5were': [2387], 'directly': [2388, 2802, 2920, 4559], 'solubilized': [2389, 2525], 'reducing': [2391, 2897], 'nonreducing': [2393, 2527, 2899], 'Laemmli': [2394], 'sample': [2395], 'buffer': [2396, 2530], 'incubated': [2398], '95': [2403], '°C.': [2404], 'Samples': [2405, 2537], 'each': [2407, 2539, 2960, 3459, 3486, 3612, 3639, 4058], 'analyzed': [2410, 2543, 2892, 2907, 2934, 3441, 3594, 3762], 'SDS-polyacrylamide': [2412], '(SDS-PAGE)': [2415, 2561], 'Western': [2417, 2547, 2903, 3218, 3764, 4517], 'blotting': [2418, 2548, 3219, 3765], '(see': [2419, 2549, 2763, 3255], 'below).': [2420, 2550], 'For': [2421, 2635, 2750, 5542], 'purification': [2423], 'resuspended': [2428, 2771, 2792], 'ml': [2431, 2501], '2.6': [2433], 'm': [2434], 'sucrose,': [2435, 2446], '20': [2436, 2447, 2595], 'mm': [2437, 2448], 'HEPES/NaOH,': [2438, 2449], 'pH': [2439, 2450], '7.2.': [2440], 'linear': [2442, 3714, 3746], 'sucrose': [2443, 2760, 3715, 3747], 'gradient': [2444, 3760], '(2.0–0.25m': [2445], '7.2)': [2451], 'layered': [2453], 'top': [2456], 'exosome': [2459, 3107, 3119, 3163], 'suspension': [2460], 'tube': [2464], 'Inc.).': [2467, 2521], 'Gradients': [2468], 'h': [2473], '100,000': [2475], 'g,': [2477], 'after': [2478, 4267, 4325], 'which,': [2479], '2-ml': [2480], 'fractions': [2481, 2769], 'collected': [2483, 2832], 'bottom': [2486], 'tube.': [2489], 'To': [2490, 2820, 3717], 'collect': [2491], 'fractions,': [2495], 'diluted': [2498], '3': [2500, 3259, 3893], 'phosphate-buffered': [2503], 'saline': [2504], '(PBS)': [2505], '200,000': [2512], 'SW50.1': [2517], 'SDS-PAGE': [2528, 2545, 2894], 'loading': [2529], 'room': [2532], 'temperature': [2533], 'min.': [2536, 2621], 'fraction': [2540], 'then': [2542, 2573, 2597, 2791, 3491, 3644], 'Proteins': [2551], 'separated': [2553], '12.5,': [2555], '10,': [2556], '7.5%': [2558], 'acrylamide': [2559], 'gels': [2560], 'transferred': [2563], 'Immobilon-P': [2565], '(Millipore,': [2567], 'Bedford,': [2568], 'blocked': [2574], '90': [2576, 2600, 2620], 'PBS': [2579], '5%': [2581], '(w/v)': [2582, 2593], 'nonfat': [2583], 'dry': [2584], 'milk': [2585], '(Protivar,': [2586], 'Nutricia,': [2587], 'Zoetermeer,': [2588], 'Netherlands)': [2590], '0.1%': [2592], 'Tween': [2594], 'reacted': [2598], 'primary': [2603], 'followed': [2605, 2649, 2901], 'labeling': [2607, 2664, 3526, 3534, 3869, 4047, 4085, 4138, 4532], '0.1': [2609, 3368, 3389, 3394, 3405], 'μg/ml': [2610], '125I-labeled': [2611], 'G': [2613], '(Zymed': [2614], 'Laboratories,': [2615], 'Francisco,': [2617], 'CA)': [2618], '125I': [2622], 'Label': [2623], 'visualized': [2625], 'quantified': [2627], 'PhosphorImager': [2630], '(Molecular': [2631], 'Dynamics,': [2632], 'Sunnyvale,': [2633], 'detection': [2636], 'antibodies,': [2639], 'secondary': [2647], 'incubation': [2651], 'with125I-labeled': [2652], 'prepared': [2658], 'ultrathin': [2660, 3528, 3859, 4491], 'cryosectioning': [2661], 'immunogold': [2663], '(45Geuze': [2668], 'Ley': [2674], 'Scheffer': [2676], 'R.C.T.': [2677], '1981;': [2681], '89:': [2682], '653-665Crossref': [2683], '(281)': [2686], '46Slot': [2689], 'Weerkamp': [2693], 'A.J.': [2694], 'Microbiol.': [2696], '1988;': [2697], '21:': [2698], '211-236Crossref': [2699], '(90)': [2701], '47Raposo': [2704], 'Posthuma': [2708], 'Herzenberg': [2714, 2718], 'L.A.': [2715, 2719], 'Weir': [2716], 'Blackwell': [2720, 2727], 'Weirs': [2722], 'Handbook': [2723], 'Experimental': [2725], 'Immunology.': [2726], 'Science,': [2728], '1997:': [2730], '208.1-208.11Google': [2731], '48Liou': [2733], 'Histochem.': [2739], '106:': [2743], '41-58Crossref': [2744], '(443)': [2747], 'microscopic': [2752], 'analysis': [2753, 3804], 'purified': [2758], 'density': [2761, 3703], 'gradients': [2762], 'above).': [2764], 'Membrane': [2765], 'relevant': [2768, 3937], 'PBS,': [2773], 'tube,': [2778], 'recentrifuged': [2780], '×g.': [2786], 'final': [2788], 'PBS/0.02%': [2794], 'sodium': [2795], 'azide.': [2796], 'Droplets': [2797], 'preparation': [2800], 'placed': [2803], 'Formvar': [2805], 'carbon-coated': [2806], 'grids.': [2807], 'Adsorbed': [2808], 'fixed': [2811], '2%': [2813], 'paraformaldehyde,': [2814], 'immunolabeled': [2815], 'stained': [2817], 'above.': [2819], 'investigate': [2821], 'presence': [2823, 2910, 2937, 3224, 3287, 4472, 4523, 5236, 5324], 'specific': [2825], 'media': [2836], 'sequential': [2838], 'centrifugations,': [2840], 'yielding': [2841], 'five': [2842], '(P1–P5),': [2844], 'highly': [2854, 3191, 3346], 'lysed,': [2886], 'equal': [2888], 'volume': [2889], 'samples': [2890], 'under': [2895], 'either': [2896], 'conditions': [2900], 'blotting.': [2904], 'P1–P5': [2905], 'II,': [2914, 3754, 3773, 4042, 4341, 4625, 5255], 'complexes.': [2929], 'adhesion': [2940, 3289, 5097, 5125, 5158, 5189, 5212], 'ICAM-1': [2942, 3294, 3312, 5216], '(CD54),': [2943], 'CD86,': [2947, 4345, 4377, 4626], 'tetraspans': [2950, 4629, 5238], 'amount': [2958], 'recovered': [2962], 'P1and': [2964], 'determined,': [2967], 'ratio': [2970, 2987, 3463, 3496, 3616, 3649, 4219], 'P5/P1': [2971, 2986, 2992, 3464, 3499, 3617, 3652], 'calculated.': [2973], 'order': [2975], 'determine': [2977, 5626], 'divided': [2989], 'value': [2993, 3507, 3660], 'obtained': [2994], 'TfR.': [2996, 3512, 3665], 'TfR,': [2997], 'served': [3006], 'reference': [3009], 'because': [3011, 3233, 5549], 'low': [3014, 4131], 'abundance': [3015, 4132], '25Raposo': [3081, 5331], 'Indeed,': [3106], 'preparations': [3108, 3120, 3164, 4484], 'TfR': [3111, 3161, 3180, 3305, 3356, 3489, 3642, 4368], '(Fig.1': [3112, 3169], 'A),': [3113], 'excluding': [3114], 'contamination': [3116], 'shed': [3122], 'Consistent': [3125], 'previous': [3127, 3668], 'observations': [3128, 4174], '8-fold': [3159], 'over': [3160, 3179, 3304, 3355, 3359, 3488, 3641, 4061, 4367], 'compared': [3165, 4166, 5231], 'whole': [3167], 'A;': [3170, 3185, 5219, 5329], 'Table': [3171, 3186, 3201, 3284, 3310, 4357, 5220], 'I).': [3172, 3187, 3202, 3217, 3285, 3311, 4358, 4370, 4470], 'Similarly,': [3173, 4995], '9-fold': [3182], '(Fig.': [3183, 3198, 3282, 3306, 3811, 3837, 3892, 3910, 3919, 4013, 4355, 5217, 5327], '1': [3184, 3199, 3307, 3509, 3662, 5218], 'all': [3194, 3949], 'tested': [3197], 'B;': [3200], 'Of': [3203], 'these,': [3204], 'CD37': [3205, 3887, 4012], '(36-fold),': [3206], 'CD81': [3207, 3786, 3913, 3941, 4782, 4885, 4957, 5120], '(124-fold),': [3208], 'CD82': [3210, 3536, 3757, 3776, 3788, 3832, 3864, 4025, 4104, 4996, 5489], '(41-fold)': [3211], 'most': [3214, 3880, 4110], 'prominently': [3215], '(Table': [3216, 4369, 4469], 'could': [3220, 3923, 4512, 5600], 'not': [3221, 3239, 3278, 3321, 3329, 3335, 4513, 4582, 4642, 5226, 5272, 5547], 'test': [3222], 'another': [3227], 'leukocytes,': [3232], 'available': [3235], 'anti-CD53': [3236], 'suitable': [3240], 'purpose.': [3243], 'However,': [3244, 4579], 'CD53': [3245, 3553, 3836, 3891, 4023, 4511, 4535, 4910, 4959, 5151], 'clearly': [3247], 'within': [3251, 3999], 'below': [3256], 'Fig.': [3258, 3444, 3597, 3981], 'B).': [3260], 'Lamp-2': [3276, 3991], '1;': [3283, 4356], 'analyzed.': [3293], 'detected': [3297, 3315, 3939, 4515], '4-fold': [3302], '(data': [3320, 3334, 5225], 'shown).': [3322, 3336, 4027], 'LFA-3': [3323, 5224], '(CD58)': [3324], 'ICAM-2': [3326], '(CD102)': [3327], 'significantly': [3330], 'Altogether,': [3337], 'results': [3339], 'selectively': [3344, 4631, 5496, 5583], 'proteins.Table': [3350], 'IRelative': [3351], 'exosomesProteinP5/P1Enrichment': [3358], 'TfRFoldTetraspan': [3360], 'proteinsCD373': [3361], '±': [3362, 3365, 3367, 3370, 3372, 3375, 3377, 3380, 3388, 3391, 3393, 3396, 3398, 3401, 3404, 3407, 3411, 3414, 3417, 3420, 3422, 3425, 3429, 3465, 3618], '0': [3363, 3373], '(6)36': [3364], '4CD630.6': [3366], '(8)7': [3369], '2CD8110': [3371], '(6)124': [3374], '10CD823.3': [3376], '0.2': [3378], '(6)41': [3379], '7Molecules': [3381], 'presentationMHC': [3385], 'II0.7': [3387], '(10)8': [3390], '2HLA-DM0.2': [3392], '(6)2': [3395], '1Ii0.02': [3397], '0.01': [3399, 3423, 3430], '(6)0.2': [3400], '0.1Adhesion': [3402], 'moleculeICAM-10.3': [3403], '(7)4': [3406], '2Costimulatory': [3408], 'moleculeCD86': [3409], '(B7.2)10': [3410], '2': [3412, 3838, 5328], '(6)10': [3413], '2Lysosomal': [3415], 'markersLamp-10.07': [3416], '0.04': [3418], '(6)0.8': [3419], '0.6Lamp-20.04': [3421], '(6)0.5': [3424], '0.2Early': [3426], 'proteinTfR0.08': [3428], '(10)P1': [3431], '(cells)': [3432, 3585], '(fraction': [3435, 3588], 'exosomes)': [3438, 3591], '1.': [3445, 3598], 'signals': [3447, 3498, 3600, 3651, 4589], 'quantitated': [3453, 3606], 'PhosphorImager,': [3456, 3609], 'protein,': [3460, 3613], 'average': [3462, 3615], 'S.D.': [3466, 3619], 'third': [3471, 3624], 'column.': [3472, 3625], 'Averages': [3473, 3626], 'presented': [3475, 3628, 4087], 'number': [3477, 3630, 4251, 4309], 'determinations': [3479, 3632], 'parentheses.': [3481, 3634], 'determined': [3492, 3645], 'calculating': [3494, 3647], 'normalizing': [3501, 3654], 'values': [3503, 3656, 4096], 'obtain': [3505, 3658], 'Open': [3513, 4275], 'table': [3514, 4276], 'new': [3517, 4279], 'tab': [3518, 4280], 'Figure': [3519, 3578], '3Intracellular': [3520], 'proteins.': [3524], 'Immunogold': [3525, 4281], 'cryosections': [3529, 3860, 4492], 'A,': [3533, 4015], 'well': [3542, 4020, 4488], 'intermediate': [3545], 'multilaminar': [3547, 3877, 3908, 4069, 4114, 4155, 4214, 4237, 4295], '(arrowheads).': [3551], 'B,': [3552, 4016], '(15-nm': [3554], 'gold': [3555, 3563, 4055, 4084, 4200, 4217, 4253, 4311], 'particles)': [3556, 3564], '(HLA-DR)': [3561], '(10-nm': [3562], 'colocalize': [3565, 3821], '(stars).': [3570], 'N,': [3571], 'nucleus;': [3572], 'bars,': [3573], 'nmView': [3575], 'Large': [3576], 'Image': [3577], 'ViewerDownload': [3579], 'Hi-res': [3580], 'image': [3581], 'Download': [3582], '(PPT)': [3583], 'study': [3669], 'II-positive': [3697, 3794], 'displayed': [3699], 'equilibrium': [3701], 'buoyant': [3702], '1.10–1.18': [3705, 3809], 'g/ml': [3706, 3712, 3810], 'peak': [3709], '1.13': [3711], 'gradients.': [3716], 'confirm': [3718], 'same': [3731], 'characteristics,': [3732], 'floated': [3743], 'gradient.': [3748], '(Fig.2': [3766, 3780, 3833], 'A).': [3767, 3886, 3912], 'distributions': [3769, 3987, 4029], 'completely': [3778], 'overlapping': [3779], 'B),': [3781], 'providing': [3782, 5645], 'evidence': [3784], 'conclusion': [3797], 'strengthened': [3800], 'whole-mount': [3802, 4483], 'equilibrating': [3807], '2,': [3812], 'C': [3813], 'andD).': [3814], 'All': [3815], 'membranes,': [3828, 4107, 4124], 'illustrated': [3830], 'C)': [3834], 'D).': [3839], 'derive': [3842], 'next': [3846, 4256, 4314], 'studied': [3847, 4757], 'various': [3853], 'highest': [3867, 4146], 'both': [3874, 3905], 'abundantly': [3881], 'latter': [3884, 4504, 5183], '(Fig.3': [3885], '(not': [3888, 4026], 'shown)': [3889], 'B)': [3894, 3921], 'primarily': [3896], '4': [3911, 3920, 3982], 'only': [3927], 'few': [3929], 'possible': [3932], 'explanation': [3933], 'inefficiently': [3943], 'due': [3944], 'epitope': [3946], 'masking.': [3947], 'confined': [3954], 'contrast,': [3963, 4117], 'Lamp-1': [3969, 4046, 4118, 5530], '–2,': [3971], 'located': [3973], 'illustrates': [3984], 'distinct': [3986, 4606], 'domains': [3995], 'exocytic': [4000, 4496], 'labeled': [4004], '4,': [4014], 'andC,': [4017], 'respectively),': [4018], 'Differential': [4028], 'evaluated': 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[4568, 4971], 'reach': [4571], 'through': [4577], 'endocytosis.': [4578], 'do': [4581], 'any': [4584], 'consensus': [4587], 'cytoplasmic': [4592], 'tail.': [4593], 'From': [4594], 'expression': [4597], 'levels': [4598], 'rates': [4607], 'between': [4610, 4762], 'suspected.': [4618], 'mechanism': [4620], 'incorporated': [4632], 'known.': [4643], 'phenomenon': [4646], 'ligand-bound': [4654], 'epidermal': [4655], 'growth': [4656], 'factor': [4657], 'resulting': [4661, 5298], 'down-regulation': [4664], 'ultimate': [4666], 'degradation': [4667, 5390], '(50Felder': [4670], 'Miller': [4672], 'Moehren': [4674], 'Ullrich': [4676, 4733], 'Schlessinger': [4678, 4731], 'Hopkins': [4680, 4735], 'C.R.': [4681], '623-624Abstract': [4685], '(384)': [4691], '51Renfrew': [4694], 'Hubbard': [4696], 'A.L.': [4697], 'Chem.': [4700], '266:': [4702], '21265-21273Abstract': [4703], 'Phosphorylation': [4710], 'annexin': [4712], 'I': [4713], 'suggested': [4719], 'induce': [4721, 5156], '(52Futter': [4727], 'C.E.': [4728], 'Felder': [4729], '120:': [4741], '77-83Crossref': [4742], '(184)': [4745], 'Even': [4748], 'though': [4749], 'precise': [4751], 'functions': [4752], 'unknown,': [4760], 'similarities': [4761], 'structures': [4764], 'suggests': [4765, 5372], 'closely': [4766], 'related': [4767], 'functions.': [4768], 'They': [4769, 5599], 'important': [4775, 4887, 4981], 'development': [4778, 4788, 4890], 'activation.': [4781], 'implicated': [4785, 5084], '(39Todd': [4789], '53Boismenu': [4810], 'Rhein': [4812], 'Fischer': [4814], 'W.H.': [4815], 'Havran': [4816], 'W.L.': [4817], 'Science.': [4818, 5570], '271:': [4820], '198-200Crossref': [4821], 'co-inducer': [4829], 'differentiation': [4832], 'immature': [4834], 'double': [4835], 'positive': [4836, 4841], 'CD4+CD8+': [4837], 'thymocytes': [4838], 'single': [4840], 'CD8+': [4844], 'T-cellsin': [4845], '(54Cibotti': [4847], 'Punt': [4849], 'Dash': [4851], 'Sharrow': [4853], 'S.O.': [4854], 'Singer': [4855], '6:': [4859], 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[5148], 'ligation': [5149], 'homotypic': [5157], '(63Lazo': [5161], 'Cuevas': [5163], 'Gutierrez': [5165], 'del': [5166], 'Arroyo': [5167], 'Orue': [5169], '178:': [5174], '132-140Crossref': [5175], '(25)': [5178], 'case,': [5184], 'authors': [5186], 'postulated': [5187], 'novel': [5188, 5201], 'mechanisms': [5190], 'among': [5191], 'lymphoid': [5192], 'modulated': [5194], 'represents': [5199], 'communication.': [5205], 'relatively': [5209], 'conventional': [5211], 'I),': [5221], 'ICAM-2,': [5222], 'shown),': [5227], 'would': [5241], 'mature': [5252], 'loading,': [5265], 'notion': [5281, 5310], 'prior': [5290, 5374], 'fusion': [5293], 'release': [5301], 'carrying': [5304], 'II.': [5308], 'supported': [5312], 'stability': [5315], 'SDS': [5326], 'Ref.': [5330], 'recruitment': [5377], 'substituted': [5404], 'peptide,': [5407], 'recently': [5491], 'II/HLA-DM': [5500], '(64Hammond,': [5502], 'C.,': [5503], 'Denzin,': [5504], 'K.,': [5506], 'Pan,': [5507], 'M.,': [5508, 5511], 'Griffith,': 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'excellent': [5703], 'photographic': [5704], 'work.': [5705]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2028248159', 'counts_by_year': [{'year': 2024, 'cited_by_count': 74}, {'year': 2023, 'cited_by_count': 65}, {'year': 2022, 'cited_by_count': 78}, {'year': 2021, 'cited_by_count': 94}, {'year': 2020, 'cited_by_count': 61}, {'year': 2019, 'cited_by_count': 57}, {'year': 2018, 'cited_by_count': 57}, {'year': 2017, 'cited_by_count': 47}, {'year': 2016, 'cited_by_count': 49}, {'year': 2015, 'cited_by_count': 42}, {'year': 2014, 'cited_by_count': 53}, {'year': 2013, 'cited_by_count': 64}, {'year': 2012, 'cited_by_count': 44}], 'updated_date': '2024-12-16T12:52:41.479833', 'created_date': '2016-06-24'}