Title: Nifedipine Attenuates Acute Hypoxic Pulmonary Vasoconstriction in Awake Piglets
Abstract: The calcium channel blocker nifedipine was administered to awake piglets to determine the drug's potential efficacy as a pulmonary vasodilator in newborns. We hypothesized that nifedipine attenuates acute hypoxic pulmonary vasoconstriction in this age group. Hemodynamic and arterial blood gas measurements were made in 24 catheterized piglets, 10 ± 3 days of age, while they breathed room air and then 12% O2,4% CO2, and 86% N2 gas. Thirteen piglets were studied before and after infusions of 15 and 40 µg·kg−1 ·min−1 of nifedipine prior to hypoxia to see if the drug prevents hypoxic pulmonary vasoconstriction. In 7 animals, nifedipine was administered after the onset of hypoxia to see if the drug reduces ongoing hypoxic pulmonary vasoconstriction. Nifedipine significantly increased heart rate (56 ± 28%) and cardiac output (48 ± 45%) and decreased systemic artery pressure (−11 ± 7%) and systemic vascular resistance (−37 ± 18%) compared with pretreatment values under normoxic conditions. Pulmonary artery pressu...
Publication Year: 1985
Publication Date: 1985-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 2
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