Title: Effect of nifedipine on vasoconstriction induced by KCl,norepinephrine and endotheine-1 in vitro rats
Abstract: Objective To observe the effect of nifedipine on vasoconstriction induced by KCl,norepinephrine(NE) and endotheine-1(ET-1) in vitro rats and also to probe the mechanisms involved.Methods The aortic rings of in vitro rats were first constricted with KCl,NE and ET-1 in the calciferous and calcium-free Krebs-Henseleit(K-H) solutions,and also to observe the effect of nifedipine on vasodilatation.Results In the calciferous K-H solution,the EC50 values of nifedipine to counteract vasoconstriction induced by KCl,NE and ET-1 were 0.072,5.34 and 0.15 μmol / L respectively.In the calcium-free K-H solution,nifedipine failed to produce the expected vasoconstriction.Conclusion The effect of nifedipine on vasoconstriction was closely correlated with the selective blocking of potential-dependent Ca2 + influx.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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