Title: Changes in Circulating Levels of LH, FSH, LHβ- and α-Subunit After Gonadotropin-Releasing Hormone, and of TSH, LHβ- and α-Subunit After Thyrotropin-Releasing Hormone
Abstract: The effect of the gonadotropin-releasing hormone (LRH) and thyrotropin-releasing hormone (TRH) on the blood levels of LH, FSH and TSH, and LHβ- and α-subunit have been studied in 4 normal subjects during the first 20 min after administration of these releasing hormones. Increases in serum immunoreactive LH, LHβ and α-subunit were seen in all subjects after LRH (100μg iv) but in all subjects the rise in LH was preceded by a rise in α-subunit. All subjects showed an increase in TSH and 3 of the 4 subjects a rise in α-subunit after TRH (200 μg) but the α-subunit responses were smaller and less consistent than after LRH. Levels of LHβ remained unchanged after TRH. The results demonstrate that the immunoreactive α-subunit of the pituitary glycoprotein hormones can be released independently of the intact hormones and that release occurs in response to the same releasing hormones, LRH and TRH, that release the intact hormones.
Publication Year: 1975
Publication Date: 1975-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 55
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