Title: Gonadotropin-Releasing Hormone Pulses: Regulators of Gonadotropin Synthesis and Ovulatory Cycles
Abstract: Early studies of the patterns of luteinizing hormone (LH) secretion in humans revealed that LH is released into the circulation in a series of pulses, and studies in animals have shown that pulses of LH reflect pulsatile secretion of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This pulsatile mode of GnRH secretion is essential for the maintenance of gonadotropin synthesis and release. GnRH secretion and the pattern of GnRH stimulation appears to be important in the differential synthesis and release of LH and follicle stimulating hormone by the pituitary gonadotrope. Therefore, this chapter examines the role of the pattern of GnRH stimulation of the gonadotrope in regulating gonadotropin synthesis and secretion. It also presents current evidence on the effects of the changes in pulsatile GnRH release during human pubertal maturation and during ovulatory cycles in women. The ability to alter the pattern of GnRH stimulation is an essential component of the regulation of reproduction in mammals.
Publication Year: 1991
Publication Date: 1991-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 146
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