Macrophages and Therapeutic Resistance in Cancer

Name: Work Video:
Duration: 3 min 30 s
Brian Ruffell; Lisa M. Coussens
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'microenvironment.': [30, 131], 'Identifying': [31, 132], 'and': [32, 51, 63, 79, 133, 152, 164, 180, 210, 220, 236, 257, 273, 297, 468, 472, 490, 564, 572, 587, 617, 706, 720, 798, 825, 865, 896, 1136, 1173, 1187, 1202, 1238, 1299, 1346, 1467, 1512, 1628, 1660, 1692, 1720, 1836, 1841, 2063, 2071, 2217, 2354, 2362, 2382, 2392, 2419, 2432, 2441, 2502, 2508, 2526, 2559, 2563, 2571, 2634, 2681, 2774, 2787, 2847, 2855, 2865, 3063, 3073, 3103, 3210, 3215, 3230, 3266, 3301, 3360, 3407, 3615, 3671, 3728, 3792, 3936, 3962], 'targeting': [33, 134, 910, 944, 1726], 'critical': [34, 135, 217, 892], 'pathways': [35, 92, 136, 193], 'that': [36, 137, 215, 496, 1694, 1728, 2482, 2556, 2744, 2756, 2765, 3167, 3449, 3633, 3870, 3933], 'improve': [37, 138], 'therapeutic': [38, 99, 139, 200, 928, 1690], 'efficacy': [39, 140, 1470, 1515, 1613, 2812, 2849, 3046], 'bolstering': [41, 142], 'anti-tumor': [42, 143, 2602, 2749, 2767, 2938], 'immune': [43, 144, 1629], 'responses': [44, 145, 1421, 1691, 1696, 2788, 3084], 'holds': [45, 146], 'great': [46, 147], 'potential': [47, 148, 3045], 'for': [48, 149, 218, 560, 741, 894, 942, 1832, 1939, 1985, 2042, 2189, 2959, 3019, 3188], 'improving': [49, 150, 3742], 'outcomes': [50, 151, 934, 2443], 'impacting': [52, 68, 153, 169], 'long-term': [53, 154], 'patient': [54, 155], 'survival.': [55, 156], 'Macrophages': [56, 157, 202, 3050], 'are': [57, 80, 158, 181, 203, 216, 258, 379, 497, 756, 858, 969, 1071, 1829, 1929, 2421, 2679, 2789, 3037, 3940], 'key': [58, 159], 'regulators': [59, 160], 'homeostatic': [61, 162, 626], 'tissue': [62, 163, 276, 473, 570, 590, 823, 2352], 'microenvironments.': [65, 166], 'Therefore,': [66, 167], 'therapeutics': [67, 168, 909], 'macrophage': [69, 170, 251, 334, 615, 815, 1236, 1732, 1772, 1942, 2027, 2213, 2415, 2463, 2483, 2781, 3138, 3245, 3400, 3499, 3603, 3747, 3780, 3850, 3934], 'presence': [70, 171, 2498], 'and/or': [71, 172, 853, 913], 'bioactivity': [72, 173], 'have': [73, 174, 748, 955, 1680, 1746, 1845, 2444, 2594], 'shown': [74, 175], 'promise': [75, 176], 'in': [76, 84, 177, 185, 205, 233, 336, 492, 624, 629, 710, 751, 817, 898, 908, 917, 935, 971, 976, 1079, 1177, 1377, 1428, 1518, 1667, 1688, 1774, 1811, 1872, 1934, 2034, 2046, 2101, 2134, 2192, 2263, 2309, 2370, 2396, 2465, 2504, 2518, 2523, 2528, 2590, 2630, 2675, 2793, 2813, 2853, 2905, 2909, 2928, 2981, 3140, 3201, 3247, 3306, 3402, 3430, 3433, 3438, 3694, 3878], 'preclinical': [77, 178], 'models': [78, 179, 712, 1179, 1254, 2815, 3404, 3929], 'now': [81, 182], 'being': [82, 183], 'evaluated': [83, 184], 'clinic.': [86, 187], 'This': [87, 188, 927, 1711, 3205, 3861], 'review': [88, 189, 1712], 'discusses': [89, 190], 'molecular/cellular': [91, 192], 'identified': [93, 194], 'so': [94, 195], 'far': [95, 196], 'whereby': [96, 197], 'macrophages': [97, 198, 299, 426, 474, 491, 541, 623, 671, 719, 788, 900, 1130, 1186, 1340, 1468, 1659, 1687, 1810, 1871, 1928, 2044, 2252, 2308, 2318, 2426, 2555, 2589, 2623, 2720, 2746, 2941, 3012, 3183, 3197, 3442, 3493, 3548, 3565, 3695, 3844, 3877, 3910], 'mediate': [98, 199], 'responses.': [100, 201], 'represented': [204], 'all': [206, 2790], 'tissues': [207], 'functionally': [209, 667, 1300, 2599, 3544], 'phenotypically': [211], 'distinct': [212, 668, 1558, 3545], 'resident': [213, 250, 622, 2033], 'populations': [214, 252, 2552], 'development': [219], 'homeostasis': [221, 235], '(Wynn': [222], 'et': [223, 264, 304, 352, 374, 400, 441, 463, 513, 535, 578, 634, 686, 764, 786, 1105, 1127, 1153, 1210, 1232, 1270, 1292, 1315, 1337, 1360, 1393, 1449, 1485, 1533, 1584, 1633, 1761, 1788, 1849, 1903, 1956, 1978, 2076, 2116, 2153, 2228, 2250, 2280, 2339, 2452, 2604, 2651, 2673, 2702, 2819, 2841, 2870, 2943, 2987, 3009, 3129, 3236, 3329, 3374, 3460, 3484, 3511, 3579, 3640, 3697, 3756, 3811, 3835, 3883, 3905, 3965, 3987, 4009, 4055], 'al.,': [224, 265, 305, 353, 401, 442, 514, 579, 635, 687, 765, 1106, 1154, 1211, 1271, 1316, 1361, 1394, 1450, 1486, 1534, 1585, 1634, 1762, 1789, 1850, 1904, 1957, 2077, 2117, 2154, 2229, 2281, 2340, 2453, 2605, 2652, 2703, 2820, 2871, 2944, 2988, 3130, 3237, 3330, 3375, 3461, 3512, 3580, 3641, 3698, 3757, 3812, 3884, 3966, 4010, 4056], '2013Wynn': [225], 'T.A.': [226], 'Chawla': [227], 'A.': [228, 309, 357, 363, 450, 462, 779, 1402, 1605, 1648, 2083, 2087, 2089, 2119, 2158, 2303, 2344, 2568, 2881, 2883, 3582, 3759], 'Pollard': [229, 869, 3107], 'J.W.': [230, 870, 3108], 'Macrophage': [231, 1415, 2569, 3080, 3351, 3662, 3719], 'biology': [232], 'development,': [234], 'disease.Nature.': [237], '2013;': [238, 477, 727, 1141, 1194, 1243, 1351, 1522, 2918, 2964, 3089, 3282, 3620, 3797], '496:': [239], '445-455Crossref': [240], 'PubMed': [241, 286, 346, 394, 435, 485, 549, 600, 680, 730, 808, 885, 1144, 1197, 1246, 1309, 1354, 1387, 1441, 1525, 1575, 1623, 1675, 1782, 1823, 1884, 1950, 1999, 2110, 2147, 2180, 2274, 2333, 2376, 2473, 2545, 2584, 2645, 2696, 2860, 2921, 2967, 3031, 3097, 3123, 3153, 3260, 3290, 3368, 3415, 3505, 3557, 3628, 3679, 3736, 3805, 3856, 3918, 4003, 4049], 'Scopus': [242, 287, 347, 395, 436, 486, 550, 601, 681, 731, 809, 886, 1145, 1198, 1247, 1310, 1355, 1388, 1442, 1526, 1576, 1624, 1676, 1783, 1824, 1885, 1951, 2000, 2111, 2148, 2181, 2275, 2334, 2377, 2474, 2546, 2585, 2646, 2697, 2861, 2922, 2968, 3032, 3098, 3124, 3154, 3261, 3291, 3369, 3416, 3506, 3558, 3629, 3680, 3737, 3806, 3857, 3919, 4004, 4050], '(462)': [243], 'Google': [244, 289, 349, 397, 438, 488, 552, 603, 683, 733, 811, 888, 1147, 1200, 1249, 1312, 1357, 1390, 1444, 1482, 1528, 1578, 1626, 1678, 1785, 1826, 1887, 1953, 2002, 2113, 2150, 2183, 2277, 2336, 2379, 2406, 2476, 2548, 2587, 2648, 2699, 2863, 2924, 2970, 3034, 3100, 3126, 3156, 3263, 3293, 3371, 3418, 3508, 3560, 3631, 3682, 3739, 3808, 3859, 3921, 4006, 4052], 'Scholar).': [245, 290, 553, 604, 734, 812, 889, 1250, 1827, 2184, 2407, 2477, 2549, 2736, 2971, 3157, 3294, 3419, 3561, 3683, 3860, 3922], 'Under': [246, 554], 'non-pathological': [247], 'conditions,': [248, 556], 'most': [249, 2551], 'derive': [253], 'from': [254, 329, 428, 673, 873, 980, 1075, 3111, 3171, 3550], 'embryonic': [255], 'progenitors': [256], 'maintained': [259], 'through': [260, 3571, 3945], 'local': [261, 562, 2520], 'proliferation': [262, 563, 616], '(Epelman': [263, 577], '2014Epelman': [266, 580], 'S.': [267, 318, 444, 458, 532, 581, 1371, 1492, 1496, 1587, 1963, 1973, 2283, 2289, 2607, 2994, 3271, 3588, 3594, 3765, 3771, 3978], 'Lavine': [268, 582], 'K.J.': [269, 583], 'Randolph': [270, 584], 'G.J.': [271, 585], 'Origin': [272, 586], 'functions': [274, 588], 'macrophages.Immunity.': [277, 385, 591], '2014;': [278, 343, 386, 546, 592, 877, 1433, 1620, 1672, 1779, 2470, 2733, 3023, 3115, 3502, 3853, 3915], '41:': [279, 387, 593, 878, 3116], '21-35Abstract': [280, 594], 'Full': [281, 283, 389, 391, 480, 482, 595, 597, 880, 882, 1436, 1438, 1994, 1996, 2144, 2328, 2330, 2540, 2542, 3026, 3028, 3092, 3094, 3118, 3120, 3148, 3150, 3255, 3257, 3285, 3287, 3623, 3625, 3800, 3802, 3998, 4000, 4044, 4046], 'Text': [282, 284, 390, 392, 481, 483, 596, 598, 881, 883, 1437, 1439, 1995, 1997, 2145, 2329, 2331, 2541, 2543, 3027, 3029, 3093, 3095, 3119, 3121, 3149, 3151, 3256, 3258, 3286, 3288, 3624, 3626, 3801, 3803, 3999, 4001, 4045, 4047], 'PDF': [285, 393, 484, 599, 884, 1440, 1998, 2146, 2332, 2544, 3030, 3096, 3122, 3152, 3259, 3289, 3627, 3804, 4002, 4048], '(87)': [288, 602], 'Exceptions': [291], 'this': [293, 818, 2193, 2204, 3435], 'include': [294], 'intestinal,': [295], 'dermal,': [296], 'alveolar': [298], 'at': [300], 'barrier': [301], 'sites': [302], '(Bain': [303], '2014Bain': [306], 'C.C.': [307, 1460, 2237], 'Bravo-Blas': [308], 'Scott': [310], 'C.L.': [311], 'Gomez': [312], 'Perdiguero': [313, 399], 'E.': [314, 365, 411, 1277, 2079, 2387, 3466, 3481, 3817, 3832], 'Geissmann': [315, 421], 'F.': [316, 422, 781, 1920, 3002, 3006, 3974], 'Henri': [317, 531], 'Malissen': [319, 533], 'B.': [320, 534, 691, 1158, 1279, 1396, 1454, 1498, 2156, 2828, 2879, 3132, 3239, 3393], 'Osborne': [321], 'L.C.': [322], 'Artis': [323], 'D.': [324, 373, 452, 456, 639, 653, 701, 773, 1122, 1126, 1168, 1332, 1336, 1369, 1398, 1408, 2660, 2838, 3338, 3463, 3516, 3530, 3584, 3649, 3706, 3761, 3814, 3984, 4020], 'Mowat': [325], 'A.M.': [326, 1926, 2611, 3894], 'Constant': [327], 'replenishment': [328], 'circulating': [330, 500], 'monocytes': [331, 471, 505], 'maintains': [332], 'pool': [335], 'intestine': [338], 'adult': [340, 494], 'mice.Nat.': [341], 'Immunol.': [342, 1474, 2106, 2580, 2692, 2962, 3144, 3251, 3281], '15:': [344], '929-937Crossref': [345], '(7)': [348], 'Scholar,': [350, 398, 439, 684, 1313, 1358, 1391, 1483, 1786, 1954, 2114, 2151, 2278, 2337, 2380, 2649, 2700, 3101, 3127, 3264, 3372, 3509, 3809, 4007, 4053], 'McGovern': [351], '2014McGovern': [354], 'N.': [355, 524, 699, 1166, 1287, 1406, 1967, 3340, 3590, 3651, 3708, 3767, 3898, 4022], 'Schlitzer': [356], 'Gunawan': [358], 'M.': [359, 454, 460, 643, 651, 1548, 1766, 1768, 1918, 1977, 2085, 2091, 2097, 2291, 2457, 2459, 3077, 3346, 3520, 3528, 3586, 3592, 3601, 3657, 3714, 3763, 3769, 3778, 3970], 'Jardine': [360], 'L.': [361, 413, 1120, 1124, 1215, 1221, 1330, 1334, 1504, 1556, 1595, 1597, 1793, 1854, 3599, 3776, 3980, 4018], 'Shin': [362], 'Poyner': [364], 'Green': [366, 2345], 'K.': [367, 405, 409, 516, 526, 530, 637, 1914, 1975, 2287, 2295, 2301, 2998, 3477, 3514, 3828], 'Dickinson': [368], 'R.': [369, 868, 1367, 2095, 2619, 2950, 3106, 3389], 'Wang': [370, 1800, 1861, 2234, 2248, 2706, 4059], 'X.N.': [371], 'Low': [372], 'al.Human': [375], 'dermal': [376], 'CD14⁺': [377], 'a': [380, 507, 759, 936, 1080, 1723, 1754, 1814, 1875, 1937, 1982, 2030, 2038, 2051, 2578, 2625, 2802, 3017, 3439], 'transient': [381], 'population': [382], 'monocyte-derived': [384], '465-477Abstract': [388], '(30)': [396], '2015Perdiguero': [402], 'E.G.': [403, 2824, 2877], 'Klapproth': [404, 529], 'Schulz': [406], 'C.': [407, 417, 641, 1591, 2293, 3275, 3334, 3471, 3518, 3645, 3702, 3822], 'Busch': [408], 'Azzoni': [410], 'Crozet': [412], 'Garner': [414], 'H.': [415, 1912, 1971, 2668, 2670, 2705], 'Trouillet': [416], 'de': [418], 'Bruijn': [419], 'M.F.': [420], 'Rodewald': [423], 'H.R.': [424], 'Tissue-resident': [425], 'originate': [427, 3170], 'yolk-sac-derived': [429], 'erythro-myeloid': [430], 'progenitors.Nature.': [431], '2015;': [432, 1476], '518:': [433], '547-551Crossref': [434], '(2)': [437], 'Yona': [440], '2013Yona': [443], 'Kim': [445], 'K.W.': [446], 'Wolf': [447, 517], 'Y.': [448, 518, 693, 783, 1116, 1160, 1326, 1636, 1764, 1965, 1969, 2455, 2715, 3475, 3483, 3826, 3834], 'Mildner': [449], 'Varol': [451], 'Breker': [453], 'Strauss-Ayali': [455], 'Viukov': [457], 'Guilliams': [459], 'Misharin': [461], 'al.Fate': [464], 'mapping': [465], 'reveals': [466, 3016], 'origins': [467], 'dynamics': [469], 'under': [475], 'homeostasis.Immunity.': [476], '38:': [478, 2538], '79-91Abstract': [479], '(359)': [487], 'Scholar)': [489, 1679, 2003, 2864, 2925, 3632], 'heart': [495], 'replaced': [498], 'bone': [501, 3181], 'marrow-derived': [502, 3182], 'Ly6C+': [503], 'inflammatory': [504, 575, 2521, 2689], 'over': [506], 'timescale': [508], 'several': [510, 957], 'weeks': [511, 632], '(Molawi': [512], '2014Molawi': [515], 'Kandalla': [519], 'P.K.': [520], 'Favret': [521], 'J.': [522, 649, 1488, 1490, 1494, 1593, 1646, 1961, 1989, 2105, 2269, 2299, 2613, 2691, 2711, 2713, 2996, 3473, 3526, 3824, 3982], 'Hagemeyer': [523], 'Frenzel': [525], 'Pinto': [527], 'A.R.': [528], 'al.Progressive': [536], 'replacement': [537], 'embryo-derived': [539], 'cardiac': [540], 'with': [542, 566, 621, 758, 790, 966, 1068, 1264, 1708, 1722, 1753, 1931, 1941, 2048, 2224, 2254, 2423, 2530, 2573, 2624, 2726, 2867, 2907, 2911, 2930, 3013], 'age.J.': [543], 'Exp.': [544], 'Med.': [545, 1242], '211:': [547], '2151-2158Crossref': [548], '(37)': [551, 3507, 3858], 'pathological': [555], 'there': [557, 904], 'evidence': [559], 'both': [561, 1839, 2417], 'recruitment,': [565, 2782], 'differences': [567], 'observed': [568, 750], 'location': [571], 'type': [573, 2007], 'insult': [576], 'Solid': [605, 977], 'tumors': [606, 838, 2985, 3448, 3939], 'appear': [607], 'be': [609, 1698, 1751, 2598, 3199, 3422, 3864], 'unique.': [610], 'Preclinical': [611], 'studies': [612, 2191, 3041, 3174], 'indicate': [613, 1693, 2481], 'minimal': [614], 'shorter': [618], 'half-lives': [619], 'compared': [620], 'counterpart': [625], 'tissues,': [627], 'measurable': [628], 'days': [630], '(Movahedi': [633], '2010Movahedi': [636, 3513], 'Laoui': [638, 3515, 3583, 3760, 3810], 'Gysemans': [640, 3517], 'Baeten': [642, 3519], 'Stangé': [644, 3521], 'G.': [645, 1500, 1603, 2093, 2125, 2285, 3469, 3522, 3820], 'Van': [646, 660, 3464, 3523, 3537, 3595, 3772, 3815], 'den': [647, 3524], 'Bossche': [648, 3525], 'Mack': [650, 3527], 'Pipeleers': [652, 3529], "In't": [654, 3531], 'Veld': [655, 3532], 'P.': [656, 659, 1363, 2350, 3533, 3536, 3968, 4016], 'De': [657, 3534], 'Baetselier': [658, 3535], 'Ginderachter': [661, 3538, 3596, 3773], 'J.A.': [662, 3539, 3597, 3774], 'Different': [663, 3540], 'microenvironments': [665, 3542], 'contain': [666, 3543], 'subsets': [669, 2074, 3546], 'derived': [672, 3549], 'Ly6C(high)': [674, 3551], 'monocytes.Cancer': [675, 3552], 'Res.': [676, 803, 1140, 1350, 1383, 1475, 1521, 1619, 1671, 1946, 2402, 2917, 3364, 3501, 3553, 3675, 3732, 3852], '2010;': [677, 1572, 2581, 3365, 3412, 3554, 3676, 3733, 3995], '70:': [678, 3366, 3555, 3677, 3734], '5728-5739Crossref': [679, 3556], '(268)': [682, 3559], 'Strachan': [685], '2013Strachan': [688, 1155], 'D.C.': [689, 1156, 1652, 2513], 'Ruffell': [690, 1157, 1278, 1392, 1453, 2152, 3128], 'Oei': [692, 1159], 'Bissell': [694, 1161], 'M.J.': [695, 767, 1162], 'Coussens': [696, 1163, 1413, 1461, 2165, 3135, 3242, 3343, 3654, 3711, 4023], 'L.M.': [697, 1164, 1414, 1462, 2166, 3136, 3243, 3344, 3655, 3712, 4024], 'Pryer': [698, 1165, 1405], 'Daniel': [700, 1167, 1407], 'CSF1R': [702, 1169, 1505], 'inhibition': [703, 1090, 1170, 1234, 1256], 'delays': [704, 1171], 'cervical': [705, 1150, 1172], 'mammary': [707, 1174, 4032], 'growth': [709, 841, 1094, 1176, 2258, 3058], 'murine': [711, 1178, 2043, 3928], 'attenuating': [714, 1181], 'turnover': [716, 1183], 'tumor-associated': [718, 1185, 1809, 1870, 2054, 2554, 3011, 3492, 3843], 'enhancing': [721, 1188, 4035], 'infiltration': [722, 1189, 1980], 'CD8(+)': [724, 1191], 'T': [725, 1192, 1419, 1465, 2138, 2683, 4026], 'cells.OncoImmunology.': [726, 1193], '2:': [728, 1195], 'e26968Crossref': [729, 1196], '(31)': [732, 1199], 'That': [735], 'said,': [736], 'CD68+': [737, 2500], 'positive': [740, 1840, 2494], 'proliferating': [742], 'cell': [743, 1102, 1581, 1616, 2103, 2266, 2312, 2984, 3172, 3178, 3279], 'nuclear': [744], 'antigen': [745, 2133], '(PCNA)': [746], 'expression': [747, 1427, 2060, 2130, 2356, 3352, 3663, 3691, 3720, 3754, 3875], 'been': [749, 1681, 1748, 1846, 2445, 2595], 'breast': [752, 796, 1296, 1380, 2171], 'cancers,': [753], 'where': [754, 1838, 2209], 'associated': [757, 789, 1752, 1930, 2422], 'poor': [760, 799, 1755, 1983], 'clinical': [761, 800, 958, 967, 1069, 1756, 2368, 2487, 3040], 'outcome': [762, 1757, 1843, 2226, 2369], '(Campbell': [763], '2011Campbell': [766], 'Tonlaar': [768], 'N.Y.': [769], 'Garwood': [770], 'E.R.': [771, 1365], 'Huo': [772], 'Moore': [774], 'D.H.': [775], 'Khramtsov': [776], 'A.I.': [777], 'Au': [778, 2157], 'Baehner': [780], 'Chen': [782, 2240], 'Malaka': [784], 'D.O.': [785], 'al.Proliferating': [787], 'high': [791, 1739], 'grade,': [792], 'hormone': [793], 'receptor': [794, 949, 1609], 'negative': [795, 1842, 2225, 2442], 'cancer': [797, 1297, 1381, 1669, 1895, 2576, 2593, 2678, 2728, 3020], 'outcome.Breast': [801], 'Cancer': [802, 1945, 2916], 'Treat.': [804, 2535], '2011;': [805, 1306, 1947, 1991, 2373, 2857], '128:': [806], '703-711Crossref': [807], '(62)': [810], 'Whether': [813], 'lifespan': [816], 'context': [819, 2194], 'reflecting': [821], 'diminished': [822], 'integrity': [824], 'extent': [827], 'damage/inflammation': [829], 'or,': [830], 'instead,': [831], 'represents': [832, 2037], 'an': [833, 918, 2428, 2686, 2748, 2772, 2796, 2899, 2978, 3052, 3427, 3575, 3879], 'adaptive': [834], 'process': [835], 'engaged': [836], 'support': [840, 2741], 'unclear,': [843], 'production': [845, 3947], 'C-C': [848], 'chemokine': [849], 'ligand': [850], '2': [851], '(CCL2)': [852], 'colony-stimulating': [854], 'factor': [855, 2259, 3298, 3327, 3397, 3960], '1': [856, 3225], '(CSF-1)': [857], 'necessary': [859], 'sustain': [861], 'their': [862, 914], 'numbers': [863], '(Noy': [864], 'Pollard,': [866, 3104], '2014Noy': [867, 3105], 'Tumor-associated': [871, 2388, 3109], 'macrophages:': [872, 2389, 3110], 'mechanisms': [874, 1716, 3112], 'therapy.Immunity.': [876, 3114], '49-61Abstract': [879, 3117], '(156)': [887, 3125], 'With': [890], 'role': [893, 2515], 'CCL2': [895], 'CSF-1': [897, 945, 948, 1564, 1608, 3209], 'recruiting': [899], 'tissue,': [903], 'growing': [906], 'interest': [907], 'these': [911, 1684, 1718, 2738, 2785, 3036, 3163], 'ligands': [912], 'respective': [915], 'receptors': [916, 2215], 'effort': [919], 'ablate': [921], 'pro-tumorigenic': [923], 'macrophages.': [926, 2055], 'approach': [929, 2778], 'has': [930, 2810, 3930], 'led': [931], 'improved': [933], 'range': [937], 'pre-clinical': [939], 'models,': [940], 'particularly': [941], 'agents': [943], 'or': [946, 1705, 2004, 2430, 2627, 2760, 3180], '(CSF-1R),': [950], 'results': [952], 'which': [954, 3067, 3196], 'spurred': [956], 'trials': [959], '(Table': [960], '1).Table': [961], '1Macrophage': [962], 'Therapeutic': [963], 'TargetingPathwayTargetaOnly': [964], 'targets': [965, 1067], 'compounds': [968, 1070], 'listed.Efficacy': [970], 'Murine': [972], 'ModelsClinical': [973], 'CompoundsClinical': [974], 'Trials': [975], 'TumorsbData': [978], 'obtained': [979, 1074, 1699], 'https://clinicaltrials.gov.RecruitmentCD11bradiation,': [981], 'chemotherapyrovelizumabCSF-1Rsingle': [982], 'agent': [983, 1006, 1016, 1024, 1050, 2933], '(GBM,': [984], 'PDAC),': [985], 'chemotherapy,': [986, 1018, 1026], 'radiation,': [987], 'angiogenesis': [988, 1019, 3614, 3791], 'inhibitorsPLX3397,': [989], 'AMG820NCT01596751': [990], '(O);': [991, 995, 997, 999, 1001, 1003, 1021], 'NCT01444404': [992], '(C);': [993, 1009, 1013, 1038, 1053, 1056, 1059], 'NCT01349036': [994], 'NCT01004861': [996], 'NCT01346358': [998], 'NCT02265536': [1000], 'NCT01494688': [1002], 'NCT02323191': [1004], '(O)IMC-CS4/LY3022855,RG7155/RO5509554CCL2single': [1005], '(metastasis,': [1007], 'PDAC)carlumabNCT00992186': [1008], 'NCT01204996': [1010], '(C)Neuropilin-1angiogenesis': [1011], 'inhibitorsMNRP1685ANCT00747734': [1012], 'NCT00954642': [1014], '(C)ANG2single': [1015], '(mammary),': [1017], 'inhibitorsnesvacumabNCT01271972': [1020], 'NCT01688960': [1022], '(O)PolarizationIL-4single': [1023], '(metastasis),': [1025], 'radiationpascolizumabIL4RαdupilumabIL-13chemotherapylebrikizumab,': [1027], 'tralokinumab,': [1028], 'GSK679586,FcγRchemotherapyrituximab': [1029], '(CD20),': [1030], 'ibrutinib': [1031], '(BTK),': [1032], 'R788': [1033], '(Syk)FunctionIL-6clazakizumab,': [1034], 'olokizumab,': [1035], 'siltuximab,': [1036], 'sirukumabNCT00433446': [1037], 'NCT00385827': [1039], '(C)NCT00841191': [1040], '(C)IL-6Rtocilizumab,': [1041], 'sarilumabTNF-αmitogen-activated': [1042], 'protein': [1043, 2804, 3226], 'kinase': [1044, 2261], 'inhibitorsadalimumab,': [1045], 'certolizumab,': [1046], 'etanercept,': [1047], 'golimumab,': [1048], 'infliximabActivationCD40single': [1049], '(PDAC),': [1051], 'chemotherapyCP-870,893NCT00711191': [1052], 'NCT01456585': [1054], '(C)NCT02157831': [1055], 'NCT01008527': [1057], '(O)NCT02225002': [1058], 'NCT00607048': [1060], '(C)NCT01103635': [1061], '(O)O,': [1062], 'ongoing;': [1063, 1084], 'C,': [1064, 1085], 'completed.a': [1065], 'Only': [1066], 'listed.b': [1072], 'Data': [1073], 'https://clinicaltrials.gov.': [1076], 'Open': [1077], 'table': [1078], 'new': [1081], 'tab': [1082], 'O,': [1083], 'completed.': [1086], 'As': [1087, 3420], 'monotherapy,': [1088], 'CSF-1R': [1089, 1255], 'alone': [1091], 'impedes': [1092], 'orthotopically': [1096], 'implanted': [1097], 'pancreatic': [1098, 1668, 2851, 2913, 2960], 'ductal': [1099, 2914], 'adenocarcinoma': [1100, 2506], '(PDAC)': [1101], 'lines': [1103, 3179], '(Mitchem': [1104], '2013Mitchem': [1107, 1317], 'J.B.': [1108, 1318, 1542, 4014], 'Brennan': [1109, 1274, 1319], 'D.J.': [1110, 1275, 1320], 'Knolhoff': [1111, 1321, 1637], 'B.L.': [1112, 1322, 1601, 1638, 1644], 'Belt': [1113, 1323], 'B.A.': [1114, 1324, 1458], 'Zhu': [1115, 1325], 'Sanford': [1117, 1327], 'D.E.': [1118, 1328], 'Belaygorod': [1119, 1329], 'Carpenter': [1121, 1331], 'Collins': [1123, 1333], 'Piwnica-Worms': [1125, 1335], 'al.Targeting': [1128, 1338, 3010], 'tumor-infiltrating': [1129, 1339, 1509, 1559, 1658], 'decreases': [1131, 1341], 'tumor-initiating': [1132, 1342], 'cells,': [1133, 1343, 2067, 2070, 2809], 'relieves': [1134, 1344], 'immunosuppression,': [1135, 1345], 'improves': [1137, 1347, 1513, 1610, 1661], 'chemotherapeutic': [1138, 1348, 2932], 'responses.Cancer': [1139, 1349], '73:': [1142, 1352, 1523], '1128-1141Crossref': [1143, 1353], '(115)': [1146, 1356], 'Scholar),': [1148, 1201, 1445, 1529, 1579, 1627, 1888, 2588, 3035, 3740], 'prevents': [1149], 'carcinogenesis': [1151], '(Strachan': [1152], 'induces': [1203], 'regression': [1204], 'glioblastoma': [1206], 'multiforme': [1207], '(GBM)': [1208], '(Pyonteck': [1209], '2013Pyonteck': [1212], 'S.M.': [1213, 2654], 'Akkari': [1214], 'Schuhmacher': [1216], 'A.J.': [1217, 1550], 'Bowman': [1218], 'R.L.': [1219], 'Sevenich': [1220], 'Quail': [1222], 'D.F.': [1223], 'Olson': [1224], 'O.C.': [1225], 'Quick': [1226], 'M.L.': [1227, 1554, 1908, 2609], 'Huse': [1228], 'J.T.': [1229], 'Teijeiro': [1230], 'V.': [1231, 1400, 3000, 3896, 4058], 'al.CSF-1R': [1233], 'alters': [1235, 3752], 'polarization': [1237, 2484, 2759, 3193, 3907, 3935], 'blocks': [1239, 1417], 'glioma': [1240], 'progression.Nat.': [1241], '19:': [1244, 2919], '1264-1272Crossref': [1245], '(174)': [1248], 'In': [1251, 2056, 2408, 2972], 'other': [1252, 1265], 'without': [1258], 'consequence': [1259], 'as': [1260, 2489, 2577, 2771, 3221, 3313], 'monotherapy.': [1261], 'However,': [1262], 'synergism': [1263], 'modalities,': [1266], 'including': [1267, 3951], 'chemotherapy': [1268, 1423], '(DeNardo': [1269], '2011DeNardo': [1272], 'D.G.': [1273, 1456, 1654, 3342, 3653, 3710, 3986, 4012], 'Rexhepaj': [1276], 'Shiao': [1280], 'S.L.': [1281, 1452], 'Madden': [1282], 'S.F.': [1283], 'Gallagher': [1284], 'W.M.': [1285, 2128], 'Wadhwani': [1286], 'Keil': [1288], 'S.D.': [1289], 'Junaid': [1290], 'S.A.': [1291, 3383], 'al.Leukocyte': [1293], 'predicts': [1295, 1981, 2721], 'survival': [1298, 2503, 2527, 2723], 'regulates': [1301, 3399, 3990], 'response': [1302, 1662, 2255, 2522], 'chemotherapy.Cancer': [1304], 'Discov.': [1305], '1:': [1307], '54-67Crossref': [1308], '(407)': [1311], 'Mitchem': [1314], 'Paulus': [1359], '2006Paulus': [1362], 'Stanley': [1364], 'Schäfer': [1366], 'Abraham': [1368], 'Aharinejad': [1370], 'Colony-stimulating': [1372], 'factor-1': [1373, 3355, 3666, 3723], 'antibody': [1374, 2799, 2903, 2980, 3015], 'reverses': [1375], 'chemoresistance': [1376], 'human': [1378, 1775, 1986, 2135, 2170, 2397, 2466, 2591, 2676], 'MCF-7': [1379], 'xenografts.Cancer': [1382], '2006;': [1384], '66:': [1385], '4349-4356Crossref': [1386], '(93)': [1389], '2014Ruffell': [1395], 'Chang-Strachan': [1397], 'Chan': [1399, 2238], 'Rosenbusch': [1401], 'Ho': [1403], 'C.M.T.': [1404], 'Hwang': [1409, 2163], 'E.S.': [1410, 2164], 'Rugo': [1411, 2159], 'H.S.': [1412, 1797, 1858, 2160], 'IL-10': [1416], 'CD8+': [1418], 'cell-dependent': [1420], 'suppressing': [1425], 'IL-12': [1426], 'intratumoral': [1429, 2016], 'dendritic': [1430, 2066], 'cells.Cancer': [1431], 'Cell.': [1432, 3022, 3088, 3619, 3796, 3994, 4040], '26:': [1434], '623-637Abstract': [1435], '(43)': [1443], 'radiation': [1446, 1472], '(Shiao': [1448], '2015Shiao': [1451], 'DeNardo': [1455, 1653, 3341, 3652, 3709, 3985, 4008], 'Faddegon': [1457], 'Park': [1459], 'TH2-polarized': [1463], 'CD4+': [1464], 'limit': [1469], 'therapy.Cancer': [1473, 3021], '(Published': [1477], 'online': [1478], 'February': [1479], '25,': [1480], '2015)https://doi.org/10.1158/2326-6066.CIR-14-0232Crossref': [1481], 'Xu': [1484, 1592, 2710], '2013Xu': [1487], 'Escamilla': [1489], 'Mok': [1491], 'David': [1493], 'Priceman': [1495], 'West': [1497, 1600, 1643], 'Bollag': [1499, 1602], 'McBride': [1501], 'W.': [1502, 2123, 2832, 2836, 2887], 'Wu': [1503, 1555, 1596], 'signaling': [1506, 3611, 3788], 'blockade': [1507, 1631, 1656, 3612, 3789], 'stanches': [1508], 'myeloid': [1510, 1560, 3177], 'radiotherapy': [1517], 'prostate': [1519], 'cancer.Cancer': [1520, 2534, 2961], '2782-2794Crossref': [1524], '(60)': [1527], 'angiogenic': [1530, 3428], 'inhibitors': [1531, 2262], '(Priceman': [1532], '2010Priceman': [1535], 'S.J.': [1536], 'Sung': [1537], 'J.L.': [1538], 'Shaposhnik': [1539], 'Z.': [1540, 2709], 'Burton': [1541], 'Torres-Collado': [1543], 'A.X.': [1544], 'Moughon': [1545], 'D.L.': [1546, 2948], 'Johnson': [1547, 3349, 3660, 3717], 'Lusis': [1549], 'Cohen': [1551], 'D.A.': [1552, 2348, 2875], 'Iruela-Arispe': [1553], 'Targeting': [1557], 'inhibiting': [1563, 1731], 'receptor:': [1565], 'combating': [1566], 'evasion': [1568], 'antiangiogenic': [1570], 'therapy.Blood.': [1571], '115:': [1573], '1461-1471Crossref': [1574], '(114)': [1577], 'adoptive': [1580, 1615], 'transfer': [1582, 1617], '(Mok': [1583], '2014Mok': [1586], 'Koya': [1588], 'R.C.': [1589], 'Tsui': [1590], 'Robert': [1594], 'Graeber': [1598], 'T.G.': [1599], 'Ribas': [1604], 'Inhibition': [1606], 'antitumor': [1612, 3617, 3794], 'immunotherapy.Cancer': [1618], '74:': [1621, 1673, 3503, 3854], '153-161Crossref': [1622], '(36)': [1625], 'checkpoint': [1630, 1665], '(Zhu': [1632], '2014Zhu': [1635], 'Meyer': [1639], 'M.A.': [1640, 2992], 'Nywening': [1641], 'T.M.': [1642], 'Luo': [1645], 'Wang-Gillam': [1647], 'Goedegebuure': [1649], 'S.P.': [1650], 'Linehan': [1651], 'CSF1/CSF1R': [1655], 'reprograms': [1657], 'T-cell': [1664, 3358, 3669, 3726], 'immunotherapy': [1666, 2958], 'models.Cancer': [1670], '5057-5069Crossref': [1674], '(33)': [1677], 'revealed.': [1682], 'Together,': [1683, 2737], 'findings': [1685, 3169], 'implicate': [1686], 'regulating': [1689], 'durable': [1695], 'may': [1697, 2020, 2480], 'augmenting': [1701], 'standard': [1702], 'care': [1704], 'emerging': [1706], 'therapies': [1707], '"macrophage': [1709], 'antagonists."': [1710], 'focuses': [1713], 'underpinning': [1717], 'observations': [1719], 'concludes': [1721], 'discussion': [1724], 'approaches': [1727], 'extend': [1729], 'beyond': [1730], 'recruitment.': [1733], 'For': [1734], 'many': [1735, 3065, 3168], 'solid': [1736, 1812, 1873], 'types,': [1738], 'densities': [1740], 'expressing': [1743], 'macrophage-associated': [1744], 'markers': [1745], 'generally': [1747], 'found': [1749, 2596, 2805, 3443], '(Figure': [1758, 3203], '1;': [1759], 'Komohara': [1760], '2014Komohara': [1763, 2454], 'Jinushi': [1765, 2456], 'Takeya': [1767, 2458], 'Clinical': [1769, 2460], 'significance': [1770, 1807, 1868, 2461], 'heterogeneity': [1773, 2464], 'malignant': [1776, 2467], 'tumors.Cancer': [1777, 2468], 'Sci.': [1778, 2175, 2469], '105:': [1780, 2471], '1-8Crossref': [1781, 2472], '(6)': [1784, 2475], 'Zhang': [1787, 2701, 3339, 3650, 3707], '2012Zhang': [1790, 1851], 'Q.W.': [1791, 1852], 'Liu': [1792, 1853], 'Gong': [1794, 1855], 'C.Y.': [1795, 1856], 'Shi': [1796, 1857], 'Zeng': [1798, 1859], 'Y.H.': [1799, 1860], 'X.Z.': [1801, 1862], 'Zhao': [1802, 1863], 'Y.W.': [1803, 1864], 'Wei': [1804, 1865], 'Y.Q.': [1805, 1866], 'Prognostic': [1806, 1867, 2304], 'tumor:': [1813, 1874], 'meta-analysis': [1815, 1876], 'literature.PLoS': [1818, 1879], 'ONE.': [1819, 1880, 2372, 2641], '2012;': [1820, 1881, 2177, 2271, 2325, 2403, 2537, 2642, 2693, 3145, 3252], '7:': [1821, 1882, 2326, 2643], 'e50946Crossref': [1822, 1883], '(96)': [1825, 1886], 'There': [1828], 'conflicting': [1830], 'data': [1831, 2739], 'lung,': [1833], 'stomach,': [1834], 'prostate,': [1835], 'bone,': [1837], 'associations': [1844], 'reported': [1847, 2446, 3164], '(Zhang': [1848], 'possibly': [1889], 'related': [1890], 'type/stage': [1893], 'evaluated,': [1896], '(e.g.,': [1897, 2011], 'Ewing': [1898], 'sarcoma': [1899], 'versus': [1900, 2015], 'osteosarcoma)': [1901], '(Buddingh': [1902], '2011Buddingh': [1905], 'E.P.': [1906, 3379], 'Kuijjer': [1907], 'Duim': [1909], 'R.A.': [1910, 2952], 'Bürger': [1911], 'Agelopoulos': [1913], 'Myklebost': [1915], 'O.': [1916, 2658], 'Serra': [1917], 'Mertens': [1919], 'Hogendoorn': [1921], 'P.C.': [1922], 'Lankester': [1923], 'A.C.': [1924, 3385], 'Cleton-Jansen': [1925], 'Tumor-infiltrating': [1927], 'metastasis': [1932, 4030], 'suppression': [1933], 'high-grade': [1935], 'osteosarcoma:': [1936], 'rationale': [1938], 'treatment': [1940], 'activating': [1943], 'agents.Clin.': [1944], '17:': [1948, 3996], '2110-2119Crossref': [1949], '(59)': [1952], 'Fujiwara': [1955], '2011Fujiwara': [1958], 'T.': [1959, 2297, 3892, 3976], 'Fukushi': [1960], 'Yamamoto': [1962], 'Matsumoto': [1964], 'Setsu': [1966], 'Oda': [1968], 'Yamada': [1970], 'Okada': [1972], 'Watari': [1974], 'Ono': [1976, 2288], 'al.Macrophage': [1979], 'prognosis': [1984, 2395, 2633], 'ewing': [1987], 'sarcoma.Am.': [1988], 'Pathol.': [1990, 2140], '179:': [1992], '1157-1170Abstract': [1993], '(40)': [2001], 'analysis': [2009], 'performed': [2010], 'quantitation': [2012], 'stromal': [2014], 'macrophages).': [2017], 'Some': [2018], 'discrepancy': [2019, 3862], 'reflect': [2022], 'use': [2024, 2186, 2976, 3317, 3925], 'different': [2026], 'markers.': [2028], 'CD68,': [2029, 2221], 'glycoprotein': [2031], 'predominantly': [2032], 'intracellular': [2035], 'granules,': [2036], 'fairly': [2039], 'specific': [2040], 'marker': [2041], 'and,': [2045, 2435, 3184, 3432], 'combination': [2047, 2906, 2929], 'F4/80,': [2049], 'identifies': [2050], 'majority': [2052], 'humans,': [2057], 'however,': [2058, 3685], 'CD68': [2059, 2100, 2132, 2188], 'widespread': [2062], 'includes': [2064, 3206], 'granulocytes,': [2065], 'fibroblasts,': [2068], 'endothelial': [2069], 'some': [2072, 3161], 'lymphoid': [2073], '(Gottfried': [2075], '2008Gottfried': [2078], 'Kunz-Schughart': [2080], 'L.A.': [2081], 'Weber': [2082], 'Rehli': [2084], 'Peuker': [2086], 'Müller': [2088], 'Kastenberger': [2090], 'Brockhoff': [2092], 'Andreesen': [2094], 'Kreutz': [2096], 'Expression': [2098], 'non-myeloid': [2102], 'types.Scand.': [2104], '2008;': [2107], '67:': [2108], '453-463Crossref': [2109], '(57)': [2112], 'Hameed': [2115], '1994Hameed': [2118], 'Hruban': [2120], 'R.H.': [2121, 2346, 2891, 2946], 'Gage': [2122], 'Pettis': [2124], 'Fox': [2126], '3rd,': [2127], 'Immunohistochemical': [2129], 'peripheral': [2136], 'blood': [2137], 'cells.Hum.': [2139], '1994;': [2141], '25:': [2142, 3024], '872-876Abstract': [2143], '(17)': [2149], '2012bRuffell': [2155], 'Esserman': [2161], 'L.J.': [2162, 2954, 3387], 'Leukocyte': [2167], 'composition': [2168], 'cancer.Proc.': [2172], 'Natl.': [2173], 'Acad.': [2174], 'USA.': [2176], '109:': [2178], '2796-2801Crossref': [2179], '(83)': [2182, 3033], 'The': [2185, 2351, 2514, 2620, 3562], 'association': [2190, 2495], 'therefore': [2196], 'variable': [2198], 'utility.': [2199], 'A': [2200, 2894, 3158], 'clear': [2201], 'example': [2202], 'non-small-cell': [2206], 'lung': [2207, 2267, 2310, 2398], 'cancer,': [2208], 'detection': [2210], 'scavenger': [2214], 'CD163': [2216, 2418], 'CD204,': [2218], 'yielded': [2222], 'correlations': [2223, 2438, 2479], '(Chung': [2227], '2012Chung': [2230], 'F.T.': [2231], 'Lee': [2232], 'K.Y.': [2233], 'C.W.': [2235], 'Heh': [2236], 'Y.F.': [2239], 'H.W.': [2241, 4060], 'Kuo': [2242], 'C.H.': [2243, 2249, 2990], 'Feng': [2244], 'P.H.': [2245], 'Lin': [2246], 'T.Y.': [2247], 'al.Tumor-associated': [2251], 'correlate': [2253], 'epidermal': [2257], 'receptor-tyrosine': [2260], 'advanced': [2264, 2912], 'non-small': [2265], 'cancer.Int.': [2268], 'Cancer.': [2270, 2732], '131:': [2272], 'E227-E235Crossref': [2273], '(10)': [2276], 'Hirayama': [2279], '2012Hirayama': [2282], 'Ishii': [2284], 'Nagai': [2286], 'Kojima': [2290], 'Yamauchi': [2292], 'Aokage': [2294], 'Hishida': [2296], 'Yoshida': [2298], 'Suzuki': [2300], 'Ochiai': [2302], 'impact': [2305], 'CD204-positive': [2307], 'squamous': [2311, 3992], 'carcinoma:': [2313], 'possible': [2314], 'contribution': [2315], 'Cd204-positive': [2317], 'tumor-promoting': [2321, 2431, 3069], 'microenvironment.J.': [2322], 'Thorac.': [2323], 'Oncol.': [2324], '1790-1797Abstract': [2327], '(9)': [2335], 'Ohri': [2338], '2011Ohri': [2341], 'C.M.': [2342], 'Shikotra': [2343], 'Waller': [2347], 'Bradding': [2349], 'microlocalisation': [2353], 'cellular': [2355], 'CD163,': [2358], 'VEGF,': [2359], 'HLA-DR,': [2360], 'iNOS,': [2361], 'MRP': [2363], '8/14': [2364], 'correlated': [2366], 'NSCLC.PLoS': [2371], '6:': [2374], 'e21874Crossref': [2375], '(21)': [2378, 2698], 'Quatromoni': [2381], 'Eruslanov,': [2383], '2012Quatromoni': [2384], 'J.G.': [2385], 'Eruslanov': [2386], 'function,': [2390], 'phenotype,': [2391, 2434], 'link': [2393], 'cancer.Am': [2399], 'J': [2400], 'Transl': [2401], '4:': [2404], '376-389PubMed': [2405], 'addition': [2409, 2973], 'potentially': [2411], 'representing': [2412], 'more': [2413, 2776], 'selective': [2414], 'biomarkers,': [2416], 'CD204': [2420], 'activation': [2424, 3989], 'toward': [2427, 2747], 'alternative': [2429, 2773], 'immunosuppressive': [2433, 2560, 3576], 'accordingly,': [2436], 'significant': [2437], 'between': [2439, 2496], 'CD163/CD204': [2440], 'across': [2447], 'multiple': [2448, 3949], 'types': [2450], '(Komohara': [2451], 'These': [2478], 'can': [2485, 3688], 'direct': [2486], 'outcome,': [2488], 'supported': [2491], 'colorectal': [2505, 2533, 2592, 2639, 2677], '(Roxburgh': [2507], 'McMillan,': [2509], '2012Roxburgh': [2510], 'C.S.': [2511], 'McMillan': [2512], 'situ': [2519], 'predicting': [2524], 'recurrence': [2525], 'patients': [2529, 2725, 2866, 2910], 'primary': [2531], 'operable': [2532], 'Rev.': [2536], '451-466Abstract': [2539], '(44)': [2547], 'Unlike': [2550], 'possess': [2557, 3068], 'pro-tumor': [2558, 2758, 3309], '(Biswas': [2562], 'Mantovani,': [2564], '2010Biswas': [2565], 'S.K.': [2566], 'Mantovani': [2567], 'plasticity': [2570], 'interaction': [2572], 'lymphocyte': [2574], 'subsets:': [2575], 'paradigm.Nat.': [2579], '11:': [2582], '889-896Crossref': [2583], '(771)': [2586], '(and': [2600], 'phenotypically)': [2601], '(Edin': [2603], '2012Edin': [2606], 'Wikberg': [2608], 'Dahlin': [2610], 'Rutegård': [2612], 'Öberg': [2614], 'Å.': [2615], 'Oldenborg': [2616], 'P.A.': [2617, 3391], 'Palmqvist': [2618], 'distribution': [2621], 'M1': [2626], 'M2': [2628], 'phenotype': [2629, 3429, 3577], 'relation': [2631], 'molecular': [2636, 3217], 'characteristics': [2637], 'cancer.PLoS': [2640], 'e47045Crossref': [2644], '(71)': [2647], 'Ong': [2650], '2012Ong': [2653], 'Tan': [2655, 3975], 'Y.C.': [2656], 'Beretta': [2657], 'Jiang': [2659], 'Yeap': [2661], 'W.H.': [2662], 'Tai': [2663], 'J.J.': [2664], 'Wong': [2665], 'W.C.': [2666], 'Yang': [2667], 'Schwarz': [2669], 'Lim': [2671], 'K.H.': [2672], 'al.Macrophages': [2674], 'pro-inflammatory': [2680], 'prime': [2682], 'towards': [2685], 'anti-tumour': [2687], 'type-1': [2688], 'response.Eur.': [2690], '42:': [2694], '89-100Crossref': [2695], '2014Zhang': [2704], 'X.': [2707], 'Shen': [2708], 'Qin': [2712], 'Sun': [2714, 2831, 2886], 'Infiltration': [2716], 'diametrically': [2718], 'polarized': [2719], 'overall': [2722], 'gastric': [2727], 'after': [2729, 3278], 'surgical': [2730], 'resection.Gastric': [2731], '2014:': [2734], '18Google': [2735], 'collectively': [2740], 'tenet': [2743], 'repolarizing': [2745], 'phenotypic': [2750], 'state,': [2751], 'either': [2752, 3326], 'impeding': [2754], 'activities/signals': [2755], 'drive': [2757, 3426, 3489, 3840], 'delivering': [2762], 'exogenous': [2763], 'signals': [2764, 3194], 'enhance': [2766], 'polarization,': [2768], 'could': [2769], 'act': [2770], 'perhaps': [2775], 'efficacious': [2777], 'blocking': [2780], 'even': [2783], 'though': [2784], 'activities': [2786, 2939, 3070, 3165], 'dynamically': [2791], 'vivo.': [2794], 'Indeed,': [2795], 'agonist': [2797, 2900], 'monoclonal': [2798, 2902], 'against': [2800, 2850], 'CD40,': [2801], 'co-stimulatory': [2803], 'professional': [2807], 'antigen-presenting': [2808], 'demonstrated': [2811], 'mouse': [2814, 3403], 'PDAC': [2817, 2868], '(Beatty': [2818, 2869], '2011Beatty': [2821], 'G.L.': [2822, 2873, 2956], 'Chiorean': [2823, 2876], 'Fishman': [2825], 'M.P.': [2826, 3336, 3647, 3704], 'Saboury': [2827, 2878], 'Teitelbaum': [2829, 2888], 'U.R.': [2830, 2889], 'Huhn': [2833], 'R.D.': [2834], 'Song': [2835], 'Li': [2837], 'Sharp': [2839], 'L.L.': [2840], 'al.CD40': [2842], 'agonists': [2843], 'alter': [2844], 'stroma': [2846], 'show': [2848], 'carcinoma': [2852], 'mice': [2854, 3320], 'humans.Science.': [2856], '331:': [2858], '1612-1616Crossref': [2859], '(463)': [2862], '2013Beatty': [2872], 'Torigian': [2874], 'Brothers': [2880], 'Alavi': [2882], 'Troxel': [2884], 'A.B.': [2885], 'Vonderheide': [2890], "O'Dwyer": [2892], 'P.J.': [2893], 'phase': [2895], 'I': [2896], 'study': [2897], 'CD40': [2901, 2957], '(CP-870,893)': [2904], 'gemcitabine': [2908], 'adenocarcinoma.Clin.': [2915], '6286-6295Crossref': [2920], '(67)': [2923], 'when': [2926], 'delivered': [2927], 'gemcitabine,': [2934], 'ostensibly': [2935], 'via': [2936], '(Vonderheide': [2942], '2013Vonderheide': [2945], 'Bajor': [2947], 'Winograd': [2949], 'Evans': [2951], 'Bayne': [2953], 'Beatty': [2955], 'Immunother.': [2963], '62:': [2965], '949-954Crossref': [2966], '(16)': [2969], 'anti-CSF-1R': [2979, 3014], 'diffuse-type': [2982], 'giant': [2983], '(Ries': [2986], '2014Ries': [2989], 'Cannarile': [2991], 'Hoves': [2993], 'Benz': [2995], 'Wartha': [2997], 'Runza': [2999], 'Rey-Giraud': [3001], 'Pradel': [3003], 'L.P.': [3004], 'Feuerhake': [3005], 'Klaman': [3007], 'I.': [3008, 3479, 3830], 'strategy': [3018], '846-859Abstract': [3025], 'first': [3039], 'demonstrate': [3043], 'macrophage-targeted': [3048], 'agents.': [3049], 'produce': [3051], 'array': [3053], 'cytokines,': [3055], 'chemokines,': [3056], 'polypeptide': [3057], 'factors,': [3059, 3950], 'hormones,': [3060], 'matrix-remodeling': [3061], 'proteases,': [3062], 'metabolites,': [3064], '(De': [3071], 'Palma': [3072, 3076], 'Lewis,': [3074], '2013De': [3075], 'Lewis': [3078], 'C.E.': [3079, 3900], 'regulation': [3081], 'anticancer': [3086], 'therapies.Cancer': [3087], '23:': [3090], '277-286Abstract': [3091], '(161)': [3099], 'Noy': [3102], '2012aRuffell': [3131, 3238], 'Affara': [3133, 3240, 3971], 'N.I.': [3134, 3241, 3972], 'Differential': [3137, 3244], 'programming': [3139, 3246], 'microenvironment.Trends': [3143, 3250], '33:': [3146, 3253], '119-126Abstract': [3147, 3254], '(207)': [3155, 3262], 'caveat': [3159], 'culture': [3173], 'utilizing': [3175], 'therefore,': [3185], 'cannot': [3186], 'account': [3187], 'complex': [3190, 3456], 'milieu': [3191], 'would': [3198], 'exposed': [3200], 'vivo': [3202], '2).': [3204], 'aforementioned': [3208], 'CCL2,': [3211], 'prostaglandin': [3212], 'E2': [3213], '(PGE2),': [3214], 'damage-associated': [3216], 'patterns': [3218], '(DAMPs)': [3219], 'such': [3220], 'high-mobility': [3222], 'group': [3223], 'box': [3224], '(HMGB1),': [3227], 'extracellular': [3228, 3232], 'ATP,': [3229], 'degraded': [3231], 'matrix': [3233], 'components': [3234], '(Ruffell': [3235], 'Zelenay': [3265], 'Reis': [3267, 3272], 'e': [3268, 3273], 'Sousa,': [3269], '2013Zelenay': [3270], 'Sousa': [3274], 'Adaptive': [3276], 'immunity': [3277], 'death.Trends': [3280], '34:': [3283], '329-335Abstract': [3284], '(25)': [3292], 'Stabilization': [3295], 'hypoxia-inducible': [3297, 3354, 3665, 3722], '(HIF)': [3299], '1α': [3300], '2α': [3302], 'important': [3305], 'mediating': [3307], 'macrophages,': [3312, 3431], 'evidenced': [3314], 'LysM-cre': [3319], 'induce': [3322, 3689], 'myeloid-specific': [3323], 'loss': [3324], '(Doedens': [3328, 3639, 3696], '2010Doedens': [3331, 3642, 3699], 'A.L.': [3332, 3643, 3700, 3890], 'Stockmann': [3333, 3644, 3701], 'Rubinstein': [3335, 3646, 3703], 'Liao': [3337, 3648, 3705], 'Karin': [3345, 3656, 3713], 'Goldrath': [3347, 3658, 3715], 'A.W.': [3348, 3659, 3716], 'R.S.': [3350, 3661, 3718], 'alpha': [3356, 3667, 3724], 'suppresses': [3357, 3668, 3725], 'function': [3359, 3401, 3670, 3727, 3937], 'promotes': [3361, 3672, 3729, 3873], 'progression.Cancer': [3363, 3674, 3731], '7465-7475Crossref': [3367, 3678, 3735], '(147)': [3370, 3681, 3738], 'Imtiyaz': [3373], '2010Imtiyaz': [3376], 'H.Z.': [3377], 'Williams': [3378], 'Hickey': [3380], 'M.M.': [3381], 'Patel': [3382], 'Durham': [3384], 'Yuan': [3386], 'Hammond': [3388], 'Gimotty': [3390], 'Keith': [3392], 'Simon': [3394], 'M.C.': [3395], 'Hypoxia-inducible': [3396], '2alpha': [3398], 'acute': [3406], 'inflammation.J.': [3409], 'Clin.': [3410], 'Invest.': [3411], '120:': [3413], '2699-2714Crossref': [3414], '(138)': [3417], 'might': [3421, 3863], 'expected,': [3423], 'hypoxic': [3424, 3445, 3569, 3606, 3750, 3783], 'conditions': [3425], 'vivo,': [3434], 'occurs': [3436], 'specifically': [3437], 'subpopulation': [3440], 'within': [3444, 3938], 'regions': [3446, 3570], 'express': [3450], 'low': [3451], 'levels': [3452], 'major': [3454], 'histocompatibility': [3455], '(MHC)': [3457], 'II': [3458], '(Laoui': [3459], '2014Laoui': [3462, 3813], 'Overmeire': [3465, 3816], 'Di': [3467, 3818], 'Conza': [3468, 3819], 'Aldeni': [3470, 3821], 'Keirsse': [3472, 3823], 'Morias': [3474, 3825], 'Movahedi': [3476, 3510, 3827], 'Houbracken': [3478, 3829], 'Schouppe': [3480, 3831], 'Elkrim': [3482, 3833], 'al.Tumor': [3485, 3836], 'hypoxia': [3486, 3687, 3837], 'does': [3487, 3838], 'differentiation': [3490, 3841], 'rather': [3495, 3846], 'fine-tunes': [3496, 3847], 'M2-like': [3498, 3849], 'population.Cancer': [3500, 3851], '24-30Crossref': [3504, 3855], 'recruitment': [3563, 3748], '(presumably': [3566], 'MHCIILO)': [3567], 'into': [3568, 3605, 3749, 3782], 'Neuropilin-1': [3572], 'supports': [3574], '(Casazza': [3578, 3755], '2013Casazza': [3581, 3758], 'Wenes': [3585, 3762], 'Rizzolio': [3587, 3764], 'Bassani': [3589, 3766], 'Mambretti': [3591, 3768], 'Deschoemaeker': [3593, 3770], 'Tamagnone': [3598, 3775], 'Mazzone': [3600, 3777], 'Impeding': [3602, 3779], 'entry': [3604, 3781], 'areas': [3608, 3751, 3785], 'Sema3A/Nrp1': [3610, 3787], 'inhibits': [3613, 3790], 'restores': [3616, 3793], 'immunity.Cancer': [3618, 3795], '24:': [3621, 3798], '695-709Abstract': [3622, 3799], '(48)': [3630, 3807], 'likely': [3635], 'upon': [3637], 'HIF-1α': [3638], 'Surprisingly,': [3684], 'although': [3686], 'HIF-1α-dependent': [3690, 3880], 'arginase-1': [3693, 3753, 3874], 'neither': [3741], 'oxygenation': [3744], 'nor': [3745], 'preventing': [3746], 'explained': [3865], 'recent': [3868], 'finding': [3869], 'lactic': [3871, 3913], 'acid': [3872], 'manner': [3881], '(Colegio': [3882], '2014Colegio': [3885], 'O.R.': [3886], 'Chu': [3887, 3891], 'N.Q.': [3888], 'Szabo': [3889], 'Rhebergen': [3893], 'Jairam': [3895], 'Cyrus': [3897], 'Brokowski': [3899], 'Eisenbarth': [3901], 'S.C.': [3902], 'Phillips': [3903], 'G.M.': [3904], 'al.Functional': [3906], 'tumour-associated': [3909], 'tumour-derived': [3912], 'acid.Nature.': [3914], '513:': [3916], '559-563Crossref': [3917], '(94)': [3920], 'Finally,': [3923], 'immune-competent': [3927], 'firmly': [3931], 'established': [3932], 'strongly': [3941], 'influenced': [3942], 'lymphocytes': [3944], 'interleukin': [3952], '(IL)-4,': [3953], 'IL-10,': [3954], 'IL-13,': [3955], 'interferon': [3956], '(IFN)-γ,': [3957], 'necrosis': [3959], '(TNF)-α,': [3961], 'immunoglobulins': [3963], '(Andreu': [3964], '2010Andreu': [3967], 'Johansson': [3969], 'Pucci': [3973], 'Junankar': [3977], 'Korets': [3979], 'Lam': [3981], 'Tawfik': [3983, 4019], 'al.FcRgamma': [3988], 'inflammation-associated': [3991], 'carcinogenesis.Cancer': [3993], '121-134Abstract': [3997], '(200)': [4005], '2009DeNardo': [4011], 'Barreto': [4013], 'Andreu': [4015], 'Vasquez': [4017], 'Kolhatkar': [4021], 'CD4(+)': [4025], 'regulate': [4028], 'pulmonary': [4029], 'carcinomas': [4033], 'protumor': [4036], 'macrophages.Cancer': [4039], '2009;': [4041], '16:': [4042], '91-102Abstract': [4043], '(474)': [4051], 'Gocheva': [4054], '2010Gocheva': [4057], 'Gadea': [4061], 'B.B': [4062]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026878412', 'counts_by_year': [{'year': 2024, 'cited_by_count': 113}, {'year': 2023, 'cited_by_count': 174}, {'year': 2022, 'cited_by_count': 176}, {'year': 2021, 'cited_by_count': 176}, {'year': 2020, 'cited_by_count': 163}, {'year': 2019, 'cited_by_count': 134}, {'year': 2018, 'cited_by_count': 96}, {'year': 2017, 'cited_by_count': 95}, {'year': 2016, 'cited_by_count': 79}, {'year': 2015, 'cited_by_count': 36}], 'updated_date': '2024-12-18T12:16:01.684393', 'created_date': '2016-06-24'}
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