TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN

Name: Work Video:
Duration: 3 min 30 s
Description: Activation of swine pepsinogen with chicken pepsin results in the formation of swine pepsin. Activation of chicken pepsinogen with swine pepsin results in the formation of chicken pepsin. The structure responsible for the species specificity of the enzyme is therefore present in the inactive precursor.
Roger M. Herriott; Quentin R. Bartz; John H. Northrop
{'id': 'https://openalex.org/W2026325401', 'doi': 'https://doi.org/10.1085/jgp.21.5.575', 'title': 'TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN', 'display_name': 'TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN', 'publication_year': 1938, 'publication_date': '1938-05-20', 'ids': {'openalex': 'https://openalex.org/W2026325401', 'doi': 'https://doi.org/10.1085/jgp.21.5.575', 'mag': '2026325401', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19873066', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2141963'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.21.5.575', 'pdf_url': 'https://rupress.org/jgp/article-pdf/21/5/575/1189926/575.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jgp/article-pdf/21/5/575/1189926/575.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109289207', 'display_name': 'Roger M. Herriott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roger M. Herriott', 'raw_affiliation_strings': ['From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California'], 'affiliations': [{'raw_affiliation_string': 'From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007956540', 'display_name': 'Quentin R. Bartz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Quentin R. Bartz', 'raw_affiliation_strings': ['From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California'], 'affiliations': [{'raw_affiliation_string': 'From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059276748', 'display_name': 'John H. Northrop', 'orcid': 'https://orcid.org/0000-0001-8676-8907'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John H. Northrop', 'raw_affiliation_strings': ['From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California'], 'affiliations': [{'raw_affiliation_string': 'From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and the Institute of Experimental Biology, University of California, Berkeley, California', 'institution_ids': ['https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.722, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.918999, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '21', 'issue': '5', 'first_page': '575', 'last_page': '582'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10404', 'display_name': 'Enzyme Catalysis and Immobilization', 'score': 0.9815, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10404', 'display_name': 'Enzyme Catalysis and Immobilization', 'score': 0.9815, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13736', 'display_name': 'Steroid Chemistry and Biochemistry', 'score': 0.934, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pepsin', 'display_name': 'Pepsin', 'score': 0.98840487}], 'concepts': [{'id': 'https://openalex.org/C16311235', 'wikidata': 'https://www.wikidata.org/wiki/Q190265', 'display_name': 'Pepsin', 'level': 3, 'score': 0.98840487}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5521565}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.513556}, {'id': 'https://openalex.org/C204241405', 'wikidata': 'https://www.wikidata.org/wiki/Q461499', 'display_name': 'Transformation (genetics)', 'level': 3, 'score': 0.43848652}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42617932}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.3485481}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06019184}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.21.5.575', 'pdf_url': 'https://rupress.org/jgp/article-pdf/21/5/575/1189926/575.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2141963', 'pdf_url': 'https://europepmc.org/articles/pmc2141963?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141963', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19873066', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1085/jgp.21.5.575', 'pdf_url': 'https://rupress.org/jgp/article-pdf/21/5/575/1189926/575.pdf', 'source': {'id': 'https://openalex.org/S168548653', 'display_name': 'The Journal of General Physiology', 'issn_l': '0022-1295', 'issn': ['0022-1295', '1540-7748'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2396161778', 'https://openalex.org/W2315537871', 'https://openalex.org/W2292401026', 'https://openalex.org/W2125080490', 'https://openalex.org/W2105637364', 'https://openalex.org/W2091182287', 'https://openalex.org/W2063417157', 'https://openalex.org/W2026325401', 'https://openalex.org/W1990632940', 'https://openalex.org/W198034794'], 'abstract_inverted_index': {'Activation': [0, 14], 'of': [1, 11, 15, 25, 35], 'swine': [2, 12, 19], 'pepsinogen': [3, 17], 'with': [4, 18], 'chicken': [5, 16, 26], 'pepsin': [6, 20], 'results': [7, 21], 'in': [8, 22, 41], 'the': [9, 23, 32, 36, 42], 'formation': [10, 24], 'pepsin.': [13, 27], 'The': [28], 'structure': [29], 'responsible': [30], 'for': [31], 'species': [33], 'specificity': [34], 'enzyme': [37], 'is': [38], 'therefore': [39], 'present': [40], 'inactive': [43], 'precursor.': [44]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2026325401', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T02:14:49.184985', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
