Response to Letter Regarding Article, “Effect of Early Metoprolol on Infarct Size in ST-Segment–Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial”

Name: Work Video:
Duration: 3 min 30 s
Borja Ibáñez; Carlos Macaya; Vicente Sánchez-Brunete; Gonzalo Pizarro; Leticia Fernández‐Friera; Alonso Mateos; Antonio Fernández‐Ortíz; José M. García‐Ruiz; Ana García‐Álvarez; Andrés Íñiguez; Luis Jesús Jiménez‐Borreguero; Pedro López‐Romero; Rodrigo Fernández‐Jiménez; Javier Goicolea; Borja Ruiz-Mateos; Teresa Bastante; Mercedes Arias; José Antonio Iglesias Vázquez; Maite Rodriguez; Noemí Escalera; Carlos Acebal; José Ángel Cabrera; Juan Valenciano; Armando Pérez de Prado; María J. Fernández-Campos; Isabel Casado; Juan C. Garcı́a-Rubira; Jaime García‐Prieto; David Sanz‐Rosa; Carlos Cuellas; Rosana Hernández‐Antolín; Agustín Albarrán; Felipe Fernández‐Vázquez; José M. de la Torre-Hernández; Stuart J. Pocock; Ginés Sanz; Valentı́n Fuster
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'Antonio': [105, 291], 'Fernández-Ortiz,': [106, 1169], 'José': [108, 141, 156, 198, 305, 424, 476, 611], 'M.': [109, 199, 306, 308, 612, 616, 1171, 1343], 'García-Ruiz,': [110, 1172], 'and': [112, 125, 149, 182, 207, 320, 371, 453, 562, 640, 659, 681, 686, 695, 731, 759, 808, 847, 899, 905, 917, 962, 991, 1077, 1089, 1112, 1121, 1367, 1755], 'Ana': [113, 321], 'García-Álvarez,': [114, 1174], 'Andrés': [116, 334], 'Iñiguez,': [117, 1184], 'Jesús': [119, 344], 'Jiménez-Borreguero,': [120, 1191], 'Pedro': [122, 358], 'López-Romero,': [123, 1193], 'PhD': [124, 185, 206], 'Rodrigo': [126, 372], 'Fernández-Jiménez,': [127, 1195], 'Javier': [129, 385], 'Goicolea,': [130, 1204], 'Ruiz-Mateos,': [133, 1211], 'Teresa': [135, 404], 'Bastante,': [136, 1217], 'Mercedes': [138, 414], 'Arias,': [139, 1224], 'A.': [142, 157, 425, 427, 477, 479, 661, 1231, 1259, 1369, 1548], 'Iglesias-Vázquez,': [143, 1232], 'Maite': [145, 438], 'D.': [146, 439, 441, 1241], 'Rodriguez,': [147, 1242], 'RN': [148], 'Noemí': [150, 454], 'Escalera,': [151, 1244], 'BPT': [152], 'Acebal,': [154, 1253], 'Cabrera,': [158, 1260], 'Juan': [160, 175, 486, 538], 'Valenciano,': [161, 1265], 'Armando': [163, 499], 'Pérez': [164, 500, 503, 1275, 1424, 1539], 'de': [165, 200, 219, 240, 243, 254, 268, 282, 296, 312, 326, 340, 349, 363, 377, 391, 409, 420, 430, 434, 445, 459, 490, 493, 501, 504, 517, 520, 530, 554, 568, 599, 613, 617, 623, 632, 646, 1141, 1155, 1158, 1177, 1188, 1198, 1208, 1220, 1228, 1234, 1238, 1247, 1267, 1270, 1276, 1285, 1288, 1295, 1314, 1335, 1344, 1350, 1358, 1425, 1446, 1535, 1540, 1642], 'Prado,': [166, 1277], 'María': [168, 511], 'J.': [169, 512, 514, 1282, 1582], 'Fernández-Campos,': [170, 1283], 'Isabel': [172, 526], 'Casado,': [173, 1293], 'C.': [176, 539, 541, 1302], 'García-Rubira,': [177, 1303], 'Jaime': [179, 549], 'García-Prieto,': [180, 1309], 'BSc': [181], 'David': [183, 563], 'Sanz-Rosa,': [184, 1311], 'Cuellas,': [187, 1320], 'Rosana': [189, 584], 'Hernández-Antolín,': [190, 1325], 'Agustín': [192, 593], 'Albarrán,': [193, 1331], 'Felipe': [195, 603], 'Fernández-Vázquez,': [196, 1338], 'la': [201, 410, 614, 618, 1221, 1345, 1447, 1536], 'Torre-Hernández,': [202, 1346], 'Stuart': [204, 627], 'Pocock,': [205, 1353], 'Ginés': [208, 641], 'Sanz,': [209, 1355], 'Valentin': [211, 654], 'Fuster,': [212, 1364], 'IbanezBorja': [215], 'Ibanez': [216, 1378, 1489], 'Centro': [217, 252, 266, 280, 294, 310, 324, 347, 361, 375, 443, 457, 552, 566, 630, 644], 'Nacional': [218, 253, 267, 281, 295, 311, 325, 348, 362, 376, 444, 458, 553, 567, 631, 645, 1140, 1176, 1197, 1246, 1313, 1357], 'Investigaciones': [220, 255, 269, 283, 297, 313, 327, 350, 364, 378, 446, 460, 555, 569, 633, 647, 1142, 1178, 1199, 1315, 1359], 'Cardiovasculares': [221, 256, 270, 284, 298, 314, 328, 351, 365, 379, 447, 461, 556, 570, 634, 648, 1179], 'III': [223, 258, 272, 286, 300, 316, 330, 353, 367, 381, 449, 463, 558, 572, 636, 650, 846, 987, 1144, 1181, 1201, 1250, 1317, 1361], '(CNIC),': [224, 259, 273, 287, 301, 317, 331, 354, 368, 382, 450, 464, 559, 573, 637, 651], 'Madrid,': [225, 234, 247, 260, 274, 288, 302, 318, 332, 355, 369, 383, 393, 402, 412, 451, 465, 474, 484, 497, 524, 536, 547, 560, 574, 591, 601, 638, 652], 'Spain': [226, 235, 248, 261, 275, 289, 303, 319, 333, 343, 356, 370, 384, 394, 403, 413, 423, 437, 452, 466, 475, 485, 498, 510, 525, 537, 548, 561, 575, 583, 592, 602, 610, 626, 639, 653], 'MacayaCarlos': [228], 'Macaya': [229, 1380, 1493], 'Hospital': [230, 388, 398, 407, 470, 481, 506, 543, 579, 587, 596, 606, 620], 'Clínico': [231, 399, 471, 544, 588, 1149, 1213, 1255, 1305, 1327], 'San': [232, 400, 472, 545, 589, 1150, 1214, 1256, 1306, 1328], 'Carlos,': [233, 401, 473, 546, 590], 'Sánchez-BruneteVicente': [237], 'Sánchez-Brunete': [238, 1382, 1495], 'Servicio': [239, 429, 489, 516, 529], 'Urgencia': [241, 491, 518, 1156, 1268, 1286], 'Médica': [242, 492, 519, 532, 1157, 1269, 1287, 1297], 'Madrid': [244, 494, 521, 1159, 1271, 1289], '(SUMMA': [245, 495, 522, 1160, 1272, 1290], '112),': [246, 496, 523], 'PizarroGonzalo': [250], 'Pizarro': [251, 1384, 1497], ',': [262, 276, 290, 304, 357], 'Fernández-FrieraLeticia': [264], 'Fernández-Friera': [265, 1386, 1509], 'MateosAlonso': [278], 'Mateos': [279, 1388, 1501], 'Fernández-OrtizAntonio': [292], 'Fernández-Ortiz': [293, 1390, 1505], 'García-RuizJosé': [307], 'García-Ruiz': [309, 1392], 'García-ÁlvarezAna': [322], 'García-Álvarez': [323, 1394], 'IñiguezAndrés': [335], 'Iñiguez': [336, 1396, 1547], 'Complejo': [337, 417], 'Hospitalario': [338, 418, 1186, 1226], 'Universitario': [339, 389, 408, 419, 482, 507, 580, 597, 607, 621, 1187, 1206, 1219, 1227, 1262, 1279, 1322, 1333, 1340, 1348], 'Vigo-Meixoeiro,': [341, 421], 'Pontevedra,': [342, 422], 'Jiménez-BorregueroJesús': [345], 'Jiménez-Borreguero': [346, 1398, 1503], 'López-RomeroPedro': [359], 'López-Romero': [360, 1400, 1499], 'Fernández-JiménezRodrigo': [373], 'Fernández-Jiménez': [374, 1402], 'GoicoleaJavier': [386], 'Goicolea': [387, 1404, 1517], 'Puerta': [390, 1207], 'Hierro,': [392], 'Ruiz-MateosBorja': [396], 'Ruiz-Mateos': [397, 1406, 1515], 'BastanteTeresa': [405], 'Bastante': [406, 1408], 'Princesa,': [411], 'AriasMercedes': [415], 'Arias': [416, 1410], 'Iglesias-VázquezJosé': [426], 'Iglesias-Vázquez': [428, 1412, 1543], 'Emergencia': [431, 1235], 'Medica': [432, 1236], '061': [433, 1237], 'Galicia-Sur,': [435], 'Galicia,': [436], 'RodriguezMaite': [440], 'Rodriguez': [442, 1414], 'EscaleraNoemí': [455], 'Escalera': [456, 1416], 'AcebalCarlos': [468], 'Acebal': [469, 1418, 1521], 'CabreraJosé': [478], 'Cabrera': [480, 1420], 'Quirón,': [483], 'ValencianoJuan': [487], 'Valenciano': [488, 1422, 1531], 'PradoArmando': [502], 'Prado': [505, 1426, 1541], 'León,': [508, 509, 581, 582, 608, 609], 'Fernández-CamposMaría': [513], 'Fernández-Campos': [515, 1428], 'CasadoIsabel': [527], 'Casado': [528, 1430, 1529], 'Atención': [531, 1296], 'Urgente': [533, 1298], '(SAMUR)–Protección': [534, 1299], 'Civil,': [535], 'García-RubiraJuan': [540], 'García-Rubira': [542, 1432, 1523], 'García-PrietoJaime': [550], 'García-Prieto': [551, 1434], 'Sanz-RosaDavid': [564], 'Sanz-Rosa': [565, 1436], 'CuellasCarlos': [577], 'Cuellas': [578, 1438], 'Hernández-AntolínRosana': [585], 'Hernández-Antolín': [586, 1440, 1519], 'AlbarránAgustín': [594], 'Albarrán': [595, 1442, 1525], 'Doce': [598, 1334], 'Octubre,': [600], 'Fernández-VázquezFelipe': [604], 'Fernández-Vázquez': [605, 1444, 1533], 'Torre-HernándezJosé': [615], 'Torre-Hernández': [619, 1448], 'Marqués': [622, 1349], 'Valdecilla,': [624], 'Santander,': [625], 'PocockStuart': [628], 'Pocock': [629, 1450], 'SanzGinés': [642], 'Sanz': [643, 1452, 1507], 'FusterValentin': [655], 'Fuster': [656, 1454, 1491], 'Zena': [658, 1366], 'Michael': [660, 1368], 'Wiener': [662, 1370], 'CVI,': [663], 'Mount': [664], 'Sinai': [665, 1372], 'School': [666, 1373], 'Medicine,': [668], 'New': [669], 'York,': [670, 1376], 'NY': [671], 'Originally': [672, 1803], 'published15': [673], 'Jul': [674], '2014https://doi.org/10.1161/CIRCULATIONAHA.114.009352Circulation.': [675], '2014;130:e19–e20We': [676], 'appreciate': [677], 'the': [678, 703, 710, 742, 747, 757, 766, 797, 824, 835, 855, 877, 883, 894, 908, 915, 945, 949, 953, 956, 989, 1002, 1037, 1049, 1066, 1086, 1094, 1099, 1119, 1133, 1473, 1552, 1621, 1709, 1718], 'interest': [679], 'comments': [682], 'by': [683, 785], 'Drs': [684, 1110], 'Argulian': [685, 1111], 'Messerli': [687, 1113], 'our': [689, 1026, 1045], 'recently': [690], 'published': [691], 'study.1': [692], 'Defining': [693], 'inclusion': [694], 'exclusion': [696], 'criteria,': [697], 'along': [698], 'with': [699, 819, 976, 1057, 1109, 1615, 1771], 'dose': [700, 916, 934, 1120], 'selection': [701], 'administered': [704], 'pharmacological': [705], 'therapy,': [706], 'is': [707, 796, 999], 'critical': [708], 'early': [711, 1012, 1458, 1572], 'stages': [712], 'a': [714, 724, 814, 940, 1115, 1129, 1136, 1564, 1715], 'clinical': [715, 906, 968, 1006, 1569], 'trial': [716, 815, 954, 1088, 1570], 'design.': [717], 'scientific': [719], 'method': [720], 'strongly': [721], 'recommends': [722], 'performing': [723], 'profound': [725], 'bibliographic': [726], 'research': [727], 'this': [729, 733, 795, 1074], 'regard,': [730], 'for': [732, 765, 809, 823, 893, 919, 1051, 1551, 1708], 'purpose,': [734], 'we': [735, 779, 812, 1106], 'carefully': [736, 964], 'reviewed': [737], 'previously': [738, 1090], 'conducted': [739, 1091], 'trials': [740], 'use': [743, 1064], 'β-blockers': [745, 830, 1097], 'setting': [748, 1100], 'ST-segment–elevation': [750, 1017, 1102], 'acute': [751, 836, 1103, 1560, 1616, 1772], 'myocardial': [752, 782, 1018, 1104, 1465, 1561, 1579, 1617, 1713, 1773], 'infarction,': [753, 1105], 'taking': [754], 'note': [755], 'strengths': [758], 'weaknesses': [760], 'each': [762], 'them.Thus,': [764], 'trial,': [778], 'randomized': [780, 860], 'anterior': [781], 'infarctions': [783], 'revascularized': [784], 'primary': [786, 1469], 'angioplasty': [787], '<6': [789], 'hours': [790, 959], 'from': [791, 802, 852, 1025, 1073], 'symptom': [792], 'onset': [793], 'because': [794], 'population': [798, 1067], 'that': [799, 881, 1068, 1114], 'most': [800, 1072], 'benefits': [801], 'any': [803, 1124], 'cardioprotective': [804], 'intervention.': [805], 'More': [806], 'important,': [807], 'safety': [810], 'reasons,': [811], 'designed': [813], 'recruit': [817], 'patients': [818, 842, 950, 975, 1021, 1056, 1467, 1614, 1770], 'no': [820], 'obvious': [821], 'contraindications': [822, 1050], 'administration': [825, 909, 1030, 1575], 'intravenous': [827, 862, 1013, 1032, 1052, 1764], 'metoprolol.': [828], 'Because': [829], 'are': [831, 1081], 'clearly': [832], 'contraindicated': [833], 'phase': [837], 'severe': [839], 'heart': [840, 1059], 'failure,': [841], 'Killip-Kimball': [844, 985], 'classes': [845], 'IV': [848], 'were': [849, 924, 1022], 'strictly': [850], 'excluded': [851, 1024], 'randomization,2': [853], 'fulfilling': [854], 'primum': [856], 'non': [857], 'nocere': [858], 'principle.Patients': [859], 'metoprolol': [863, 871, 921, 938, 1033, 1459, 1574, 1767], 'received': [864], 'up': [865], 'three': [867], '5-mg': [868], 'boluses': [869], 'tartrate': [872], '2': [873], 'minutes': [874], 'apart,': [875], 'following': [876, 1610], 'same': [878], 'scheme': [879], 'as': [880], 'Thrombolysis': [884, 1622], '(TIMI)': [888, 1626], 'II-B': [889, 1627], 'trial,3': [890], 'closely': [891], 'checking': [892], 'presence': [895], 'contraindications—heart': [897], 'rhythm': [898], 'rate,': [900], 'PR-interval': [901], 'duration,': [902], 'blood': [903, 979], 'pressure,': [904], 'examination—before': [907], 'every': [911], 'single': [912], 'bolus.': [913], 'Similarly,': [914], 'timing': [918, 1122], 'oral': [920, 1766], 'after': [922], 'reperfusion': [923], 'selected': [925], 'according': [926, 966], 'current': [928], 'recommendations.4': [929], 'Thus,': [930], 'initial': [932, 977], 'low': [933], '25': [936], 'mg': [937], 'twice': [939], 'day': [941], 'was': [942, 963], 'initiated': [943], 'vast': [946], 'majority': [947], 'included': [951], 'within': [955], 'first': [957], '24': [958], 'admission': [961], 'titrated': [965], 'judgment.The': [969], 'increase': [970, 1036], 'mortality': [972], 'observed': [973], 'systolic': [978], 'pressure': [980], '<120': [981], 'mm': [982], 'Hg': [983], 'or': [984], 'class': [986], 'Clopidogrel': [990], 'Trial': [996], '(COMMIT)': [997], 'trial5': [998], 'one': [1000], 'main': [1003], 'reasons': [1004], 'why': [1005], 'practice': [1007], 'guidelines': [1008], 'do': [1009], 'not': [1010, 1035], 'emphasize': [1011], 'β-blocker': [1014, 1053], 'initiation': [1015], 'infarction.': [1019], 'These': [1020], 'systematically': [1023], 'trial;': [1027], 'consequently,': [1028], 'prereperfusion': [1029], 'did': [1034], 'incidence': [1038], 'major': [1040], 'adverse': [1041], 'cardiac': [1042], 'events': [1043], 'study.': [1046], 'This': [1047], 'reinforces': [1048], 'therapy': [1054, 1612], 'overt': [1058], 'failure': [1060], 'but': [1061], 'supports': [1062], 'its': [1063], 'can': [1069, 1127], 'potentially': [1070], 'benefit': [1071], 'inexpensive,': [1075], 'safe,': [1076], 'effective': [1078], 'intervention.Although': [1079], 'there': [1080], 'other': [1082], 'important': [1083], 'differences': [1084], 'between': [1085], 'METOCARD-CNIC': [1087], 'studies': [1092], 'evaluating': [1093], 'effect': [1095], 'totally': [1107], 'agree': [1108], 'careful': [1116], 'design': [1117, 1550], 'given': [1125], 'intervention': [1126], 'make': [1128], 'huge': [1130], 'difference': [1131], 'outcomes': [1134], 'trial.Borja': [1137], 'MDCentro': [1139, 1175, 1196, 1356], 'CardiovascularesCarlos': [1143, 1200, 1316, 1360], '(CNIC)Madrid,': [1145, 1182, 1202, 1251, 1318, 1362], 'SpainCarlos': [1146, 1252, 1319], 'MDHospital': [1148, 1205, 1212, 1218, 1254, 1261, 1278, 1304, 1321, 1326, 1332, 1339, 1347], 'CarlosMadrid,': [1151, 1215, 1257, 1307, 1329], 'SpainVicente': [1152], 'MDServicio': [1154, 1233, 1266, 1284, 1294], '112)Madrid,': [1161, 1273, 1291], 'SpainGonzalo': [1162], 'MDLeticia': [1164], 'MDAlonso': [1166], 'MDAntonio': [1168], 'MDJosé': [1170], 'MDAna': [1173], 'SpainAndrés': [1183], 'MDComplejo': [1185, 1225], 'Vigo-MeixoeiroPontevedra,': [1189, 1229], 'SpainJesús': [1190], 'MDPedro': [1192], 'PhDRodrigo': [1194], 'SpainJavier': [1203], 'HierroMadrid,': [1209], 'SpainBorja': [1210], 'SpainTeresa': [1216], 'PrincesaMadrid,': [1222], 'SpainMercedes': [1223], 'SpainJosé': [1230, 1258, 1342], 'Galicia-SurGalicia,': [1239], 'SpainMaite': [1240], 'RNNoemí': [1243], 'BPTCentro': [1245], 'InvestigacionesCardiovasculares': [1248], 'QuirónMadrid,': [1263], 'SpainJuan': [1264, 1301], 'SpainArmando': [1274], 'LeónLeón,': [1280, 1323, 1341], 'SpainMaría': [1281], 'SpainIsabel': [1292], 'CivilMadrid,': [1300], 'SpainJaime': [1308], 'BScDavid': [1310], 'PhDCentro': [1312], 'SpainRosana': [1324], 'SpainAgustín': [1330], 'OctubreMadrid,': [1336], 'SpainFelipe': [1337], 'ValdecillaSantander,': [1351], 'SpainStuart': [1352], 'PhDGinés': [1354], 'SpainValentin': [1363], 'MDThe': [1365], 'CVIMount': [1371], 'MedicineNew': [1375], 'NYDisclosuresNone.References1.': [1377], 'B,': [1379, 1407, 1490, 1516], 'C,': [1381, 1419, 1439, 1494, 1522], 'V,': [1383, 1492, 1496], 'G,': [1385, 1453, 1498, 1508], 'L,': [1387, 1510], 'A,': [1389, 1391, 1395, 1397, 1427, 1443, 1502, 1506, 1526, 1542], 'JM,': [1393, 1449, 1538], 'J,': [1399, 1405, 1423, 1435, 1504, 1518, 1532], 'P,': [1401, 1500, 1546], 'R,': [1403, 1441, 1520, 1587, 1744, 1746], 'T,': [1409], 'M,': [1411], 'JA,': [1413, 1421, 1544, 1644, 1658], 'N,': [1417, 1666], 'MJ,': [1429, 1668], 'I,': [1431, 1530], 'JC,': [1433, 1524, 1648], 'D,': [1437, 1692], 'F,': [1445, 1534], 'S,': [1451, 1603], 'V.': [1455], 'infarct': [1461], 'size': [1462], 'ST-segment-elevation': [1464], 'infarction': [1466], 'undergoing': [1468], 'percutaneous': [1470], 'coronary': [1471], 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