Publication Information

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'https://openalex.org/W2048831707', 'https://openalex.org/W1983998081', 'https://openalex.org/W1983788113'], 'abstract_inverted_index': {'Long-term': [0, 75, 235, 310, 528, 3431, 3785], 'alcohol': [1, 76, 236, 311, 909, 1341, 2465, 2496, 2507, 2540, 2822, 3196, 3432, 3783, 3786, 3966, 4693, 4717, 4734, 4814, 4850, 4879, 4937], 'exposure': [2, 77, 237, 312, 530, 1173, 1342, 1567, 2449, 2497, 2719, 3106, 3197, 3261, 3433, 3787, 4179, 4694, 4735, 4759, 4851], 'sensitizes': [3, 238, 1343, 1428, 1467, 1576, 1784, 1844, 1902, 3698, 4956], 'hepatocytes': [4, 94, 143, 164, 239, 329, 378, 399, 1328, 1344, 1382, 1429, 1577, 1616, 1810, 2690, 2740, 3149, 3699, 3716, 4048, 4200, 4271, 4335, 4858, 4890, 4957], 'to': [5, 95, 211, 240, 330, 446, 543, 594, 634, 849, 975, 1095, 1115, 1130, 1161, 1174, 1279, 1331, 1345, 1430, 1468, 1494, 1548, 1559, 1568, 1578, 1689, 1785, 1845, 1903, 1945, 2397, 2518, 2531, 2578, 2593, 2602, 2625, 2693, 2720, 2832, 3036, 3053, 3107, 3111, 3120, 3164, 3221, 3262, 3304, 3318, 3363, 3381, 3428, 3470, 3653, 3661, 3700, 3731, 3812, 3894, 3945, 4017, 4024, 4052, 4108, 4115, 4139, 4146, 4183, 4186, 4203, 4278, 4295, 4331, 4336, 4551, 4572, 4585, 4625, 4958, 5015, 5150], 'tumor': [6, 241, 820, 970, 1000, 1028, 1062, 1108, 1162, 1217, 1371, 1431, 4521, 4789], 'necrosis': [7, 242, 821, 971, 1001, 1029, 1063, 1109, 1163, 1167, 1218, 1372, 1432, 4522, 4790], 'factor-α': [8, 243, 972, 1164], '(TNF)': [9, 244, 973], 'cytotoxicity.': [10, 245, 3430, 3702], '4-Hydroxynonenal': [11, 246, 4516], '(4-HNE)': [12, 247, 1500], 'is': [13, 248, 552, 670, 735, 1501, 3778, 3788, 3808, 4165, 4548, 4589, 4650, 4666, 4846, 4870, 4966], 'one': [14, 249, 1502, 2321], 'of': [15, 43, 57, 113, 135, 137, 148, 152, 172, 221, 250, 278, 292, 348, 370, 372, 383, 387, 407, 456, 483, 533, 562, 582, 618, 701, 741, 846, 934, 954, 969, 978, 1106, 1216, 1252, 1267, 1272, 1303, 1386, 1424, 1503, 1515, 1536, 1584, 1728, 1755, 1760, 1875, 1935, 1948, 1955, 1961, 1986, 1993, 2008, 2056, 2098, 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4349, 4412, 4545, 4549, 4580, 4689, 4702, 4726, 4995, 5000, 5007, 5042], 'most': [17, 252, 1505], 'abundant': [18, 253, 1506], 'and': [19, 32, 50, 81, 144, 194, 207, 254, 267, 285, 316, 379, 429, 442, 475, 481, 493, 513, 541, 565, 589, 627, 665, 689, 719, 783, 819, 824, 875, 910, 994, 1032, 1168, 1244, 1265, 1299, 1305, 1379, 1446, 1473, 1507, 1526, 1600, 1646, 1733, 1739, 1745, 1747, 1790, 1850, 1880, 1908, 1973, 2038, 2199, 2247, 2253, 2326, 2338, 2345, 2381, 2443, 2557, 2562, 2646, 2657, 2672, 2737, 2762, 2808, 2851, 2858, 2917, 2941, 2960, 2965, 3007, 3146, 3175, 3187, 3207, 3216, 3270, 3284, 3306, 3316, 3444, 3577, 3605, 3640, 3657, 3687, 3717, 3772, 3794, 3821, 3826, 3967, 4128, 4130, 4197, 4250, 4394, 4398, 4426, 4430, 4491, 4520, 4529, 4684, 4706, 4721, 4769, 4829, 4860, 4917, 4947, 4950, 4986, 4990, 5088, 5100, 5148], 'reactive': [20, 255, 534, 1508, 4079], 'lipid': [21, 256, 556, 563, 587, 625, 663, 706, 717, 851, 873, 1497, 3796, 3911, 4984], 'peroxides.': [22, 257], 'Increased': [23, 258, 662, 999, 3907], 'hepatic': [24, 79, 191, 196, 259, 314, 426, 431, 567, 1166, 2438, 2444, 2476, 2510, 2544, 2560, 2825, 3199, 3204, 3209, 3438, 3574, 3599, 3629, 3684, 3769, 4696, 4737, 4918, 4945], '4-HNE': [25, 45, 80, 109, 128, 154, 192, 202, 223, 260, 280, 315, 344, 363, 389, 427, 437, 458, 1524, 1542, 2351, 2511, 2523, 2545, 2561, 2572, 2591, 2621, 2709, 2721, 2727, 2744, 2768, 2884, 2895, 2929, 3020, 3069, 3109, 3141, 3324, 3345, 3388, 3499, 3508, 3514, 3529, 3532, 3575, 3600, 3630, 3656, 3685, 3697, 3738, 3770, 3805, 3873, 4021, 4037, 4067, 4105, 4329, 4352, 4365, 4371, 4377, 4415, 4438, 4479, 4554, 4566, 4584, 4631, 4653, 4668, 4946, 4955, 5067, 5129], 'contents': [26, 261, 2440, 2546], 'present': [27, 37, 262, 272, 1555, 4012, 4727], 'in': [28, 54, 140, 145, 185, 263, 289, 375, 380, 420, 478, 546, 592, 632, 676, 681, 686, 737, 749, 776, 827, 831, 878, 937, 1006, 1035, 1070, 1134, 1148, 1176, 1221, 1225, 1356, 1376, 1471, 1480, 1522, 1532, 1552, 1629, 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4729], 'investigated': [40, 275, 2707], 'effects': [42, 277, 3073, 3343, 3458, 4413, 4690, 5033, 5051], 'intracellular': [44, 153, 222, 279, 388, 457, 1448, 2726, 3355, 3371, 3391, 3507, 3513, 3528, 3737, 4954, 5066], 'accumulation': [46, 155, 203, 281, 390, 438, 877, 3530], 'on': [47, 181, 282, 416, 586, 620, 1283, 2135, 2280, 2509, 2769, 2885, 2896, 3039, 3074, 3763, 4416, 4570, 4695, 4788, 5120], 'TNF-induced': [48, 111, 212, 283, 346, 447, 1332, 1549, 1579, 2579, 2694, 2711, 2749, 2897, 2933, 3222, 3701, 4140, 4325, 5121], 'hepatotoxicity': [49, 284, 775, 1470, 1787, 1847, 1905, 4989], 'its': [51, 286, 1253, 2661, 2833, 4574, 4621, 4661, 4991, 5031], 'potential': [52, 228, 287, 463, 2062, 2185, 4981, 5079], 'implication': [53, 288], 'pathogenesis': [56, 291, 977, 3663, 4996], 'alcoholic': [58, 232, 293, 467, 484, 494, 678, 746, 774, 938, 955, 982, 1007, 1037, 1072, 1096, 1116, 1198, 1481, 1798, 1858, 1916, 2065, 2188, 3916, 4910], 'liver': [59, 183, 233, 294, 418, 468, 485, 495, 550, 595, 635, 674, 679, 721, 748, 829, 857, 905, 927, 939, 956, 1132, 1146, 1199, 1223, 1474, 1482, 1748, 1761, 1791, 1799, 1851, 1859, 1909, 1917, 2009, 2066, 2082, 2189, 2555, 2806, 3539, 3620, 3678, 3777, 3892, 3917, 3962, 3994, 4158, 4248, 4762, 4794, 4911], 'disease.': [60, 234, 295, 469], 'Male': [61, 296, 1658, 2405], 'C57BL/6': [62, 297, 1659, 2406], 'mice': [63, 298, 1188, 1472, 1660, 1789, 1849, 1907, 2407, 2432, 2567], 'were': [64, 299, 1557, 1589, 1608, 1617, 1627, 1674, 1685, 1736, 1743, 1750, 1811, 1966, 2041, 2203, 2235, 2267, 2305, 2315, 2335, 2365, 2383, 2395, 2420, 2479, 2491, 2666, 2684, 2691, 2980, 3162, 3242, 3287, 3582, 3724, 4424, 4704], 'fed': [65, 300, 683, 1675, 2411], 'an': [66, 301, 1135, 1679, 1703, 1983, 1990, 2127, 2238, 2867, 3061, 3091, 3401, 3588, 4358], 'ethanol-containing': [67, 302, 1680, 1723], 'or': [68, 303, 711, 715, 1572, 1702, 2011, 2084, 2156, 2227, 2352, 3182, 3251, 4213, 4404, 4646], 'a': [69, 158, 174, 178, 205, 227, 304, 393, 409, 413, 440, 462, 473, 1086, 1107, 1476, 1546, 1653, 1697, 1793, 1817, 1853, 1911, 1952, 2061, 2090, 2105, 2136, 2152, 2184, 2254, 2281, 2376, 2423, 2434, 2525, 2576, 2730, 3248, 3253, 3329, 3405, 3448, 3668, 3706, 3741, 3745, 3851, 4032, 4043, 4113, 4150, 4166, 4192, 4273, 4344, 4595, 4873, 4941, 5078], 'control': [70, 305, 1705], 'diet': [71, 306, 1682, 1707, 1724, 2416, 3591], 'for': [72, 231, 307, 466, 705, 1711, 1996, 2064, 2187, 2298, 2330, 2389, 2417, 2596, 2638, 2722, 2870, 3063, 3094, 3257, 3782, 4157, 4169, 4361, 4401, 4583, 4660, 4905, 5054, 5081, 5096, 5132, 5140, 5152], '5': [73, 308, 1643, 1712, 2331, 2418], 'weeks.': [74, 309, 1713], 'increased': [78, 127, 133, 201, 313, 362, 368, 436, 985, 1447, 1686, 2470, 2481, 2543, 2725, 2909, 2986, 3112, 3139, 3198, 3390, 3683, 3791, 4173, 4178, 4332, 4604], 'TNF': [82, 96, 166, 317, 331, 401, 987, 1087, 1129, 1191, 1240, 1247, 1280, 1527, 2477, 2489, 2563, 2600, 2626, 2782, 2837, 2906, 2915, 2956, 2975, 3040, 3081, 3301, 3364, 3429, 3658, 3688, 4147, 4163, 4188, 4204, 4279, 4298, 4337, 4948, 4959, 5137], 'levels.': [83, 318, 3357, 4030], 'Cell': [84, 319, 1869, 2606, 3859], 'culture': [85, 320, 3161], 'studies': [86, 321, 1556, 2665, 3338], 'revealed': [87, 125, 322, 360, 1350, 3298, 3705], 'that': [88, 108, 126, 219, 323, 343, 361, 454, 1142, 1339, 1351, 1566, 2464, 3019, 3068, 3281, 3340, 3419, 3676, 3696, 3756, 4104, 4143, 4154, 4322, 4553, 4565, 4652, 4667, 4732, 4848, 4877, 4935, 4951], '4-HNE,': [89, 324, 1569, 3472, 4053], 'at': [90, 325, 1570, 1650, 1725, 1752, 1951, 1982, 2278, 2301, 2328, 2401, 2971, 3077, 3101, 3313, 3321, 4055, 4106, 5094], 'nontoxic': [91, 326, 1571], 'concentrations,': [92, 327, 1575, 4057], 'sensitized': [93, 328, 2622, 4136], 'killing,': [97, 332, 4141], 'which': [98, 333, 989, 1296, 2945, 3491, 3624, 3723, 4657], 'was': [99, 130, 187, 334, 365, 422, 1719, 1763, 1871, 1943, 1977, 2014, 2087, 2101, 2118, 2147, 2164, 2286, 2341, 2356, 2373, 2467, 2516, 2608, 2630, 2772, 2803, 2815, 2866, 2920, 2946, 2999, 3031, 3051, 3087, 3118, 3137, 3366, 3422, 3434, 3474, 3484, 3492, 3592, 3625, 3652, 3680, 3765, 3875, 4022, 4341, 4608, 4891], 'associated': [100, 131, 188, 335, 366, 423, 553, 671, 2468, 2947, 3435, 3493, 3626, 3725, 3766, 3789], 'with': [101, 132, 189, 336, 367, 424, 554, 672, 708, 923, 981, 991, 1093, 1113, 1678, 1696, 1816, 1938, 1970, 2029, 2089, 2126, 2269, 2288, 2309, 2428, 2456, 2469, 2549, 2590, 2928, 2948, 3151, 3244, 3399, 3436, 3494, 3614, 3627, 3726, 3767, 3790, 3882, 3915, 4272, 4635, 4639, 4655, 4744, 5030, 5057, 5111, 5128, 5164], 'suppressed': [102, 337, 2748, 3021, 3203, 3486, 3727, 3732, 4480], 'NF-κB': [103, 169, 197, 338, 404, 432, 1320, 1585, 2000, 2712, 2752, 2770, 2796, 2813, 2839, 2886, 3008, 3022, 3172, 3230, 3580, 3733, 3774, 4190, 4211, 4252, 4293, 4326, 4362, 4417, 4457, 4481, 4518, 4557, 4697, 4738, 4855, 4882, 4887, 4964], 'transactivity.': [104, 339, 2713, 4739], 'Further': [105, 340], 'investigation': [106, 341, 5076], 'demonstrated': [107, 342, 1338, 3695, 3755], 'prevented': [110, 345], 'inhibitor': [112, 347, 1266, 2258, 4390], 'κBα': [114, 138, 349, 373], 'phosphorylation': [115, 350, 2846, 2863, 2898, 2911, 2937, 3050, 3076, 3177, 3607, 3643, 4355, 4486, 4528, 4563, 4575, 4622, 4662], 'without': [116, 351], 'affecting': [117, 352], 'upstream': [118, 353, 3034], 'IκB': [119, 354, 4527], 'kinase': [120, 355, 1310, 2221, 3035, 4768], 'activity.': [121, 198, 356, 433, 2829], 'An': [122, 357, 4902], 'immunoprecipitation': [123, 358, 2239, 2275, 2310, 3116], 'assay': [124, 359, 1815, 1819, 2019], 'content': [129, 364, 2952, 3631], 'formation': [134, 369, 561, 631, 1271, 1525, 3576, 3637, 3686, 3712, 3771, 4591, 4607, 4619], '4-HNE–inhibitor': [136, 371], 'adduction': [139, 374], '4-HNE–treated': [142, 377, 3715], 'livers': [147, 382, 3719], 'mice.': [150, 385, 3189], 'Prevention': [151, 386], 'by': [156, 391, 778, 853, 908, 1004, 1171, 1318, 1383, 1426, 1813, 1873, 1979, 2059, 2151, 2182, 2343, 2350, 2358, 2386, 2494, 2522, 2613, 2633, 2775, 2847, 2855, 2991, 3002, 3090, 3126, 3140, 3353, 3368, 3487, 3498, 3682, 3965, 4177, 4231, 4328, 4343, 4454, 4488, 4495, 4525, 4576, 4686, 4864, 4872, 5136], 'bezafibrate,': [157, 392, 3740], 'peroxisome': [159, 394, 3439], 'proliferator-activated': [160, 395, 3440], 'receptor-α': [161, 396, 3441], 'agonist,': [162, 397, 3743], 'protected': [163, 398, 3536], 'from': [165, 400, 1138, 1293, 1512, 1591, 1610, 1619, 1687, 2079, 2805, 3159, 3185, 3348, 3464, 3537, 3720, 3810, 3885, 3990, 4098, 4317, 4681, 4712], 'killing': [167, 402], 'via': [168, 403, 1270, 1582, 3024, 4483, 4610, 4637, 4674, 5064], 'activation.': [170, 405, 1586, 3231, 3734, 3775, 5123], 'Supplementation': [171, 406], 'N-acetylcysteine,': [173, 408], 'glutathione': [175, 410, 1401, 1422], 'precursor,': [176, 411, 3407], 'conferred': [177, 412, 3447, 3744], 'protective': [179, 414, 739, 3586, 3746, 5009], 'effect': [180, 415, 2504, 2766, 2882, 3450, 3747, 3759, 4035, 5119], 'alcohol-induced': [182, 417, 720, 828, 926, 1131, 1222, 3538, 3554, 3677], 'injury': [184, 419, 551, 675, 1133, 1147, 1224, 2556, 3621, 3679, 4159, 4763], 'mice,': [186, 421, 3616, 3722], 'decreased': [190, 425, 566, 1067, 1399, 2777, 2824, 2949, 3048, 3208, 3354, 3437, 3634, 3768, 4366, 4372], 'formation,': [193, 428, 560, 3115, 3170, 3604, 4677], 'improved': [195, 430, 3641, 3773], 'conclusion,': [200, 435, 4931], 'represents': [204, 439, 4149, 4191], 'potent': [206, 441], 'clinically': [208, 443, 4151], 'relevant': [209, 444, 1493, 3163, 4152], 'sensitizer': [210, 445, 1547, 2577], 'hepatotoxicity.': [213, 448, 1333, 1347], 'These': [214, 449, 3015, 4740], 'data': [215, 450, 1127, 2364, 2382, 4975], 'support': [216, 451, 5099], 'notion': [218, 453, 2998, 4869], 'removal': [220, 455], 'can': [224, 459, 1290], 'serve': [225, 460, 1544], 'as': [226, 461, 1545, 1765, 1825, 1883, 2043, 2166, 2367, 2422, 2575, 3404, 3850, 3938, 3940, 4223, 4643, 5069, 5077, 5157], 'therapeutic': [229, 464, 5050], 'option': [230, 465], 'Oxidative': [470, 491], 'stress': [471, 492, 545, 3352, 3421, 3793], 'plays': [472], 'central': [474], 'causal': [476], 'role': [477, 933, 1215, 4904, 5010], 'onset': [480], 'progression': [482], 'disease': [486, 680, 830, 992, 1534], '(ALD).1Wu': [487], 'D.': [488, 798, 4513, 4808, 4901], 'Cederbaum': [489], 'A.I.': [490], 'disease.Semin': [496], 'Liver': [497], 'Dis.': [498], '2009;': [499], '29:': [500, 944], '141-154Crossref': [501], 'PubMed': [502, 523, 600, 643, 695, 755, 790, 837, 917, 963, 1012, 1042, 1080, 1121, 1182, 1235, 1394, 1487, 1804, 1864, 1922, 2071, 2194, 3564, 3835, 3864, 3925, 3974, 4005, 4092, 4265, 4310, 4465, 4537, 4778, 4800, 4840, 4925], 'Scopus': [503, 524, 601, 644, 696, 756, 791, 838, 964, 1013, 1043, 1081, 1122, 1183, 1236, 1395, 1442, 1488, 1805, 1865, 1923, 2072, 2195, 3565, 3836, 3865, 3926, 3975, 4006, 4093, 4266, 4311, 4466, 4538, 4779, 4801, 4841, 4926], '(262)': [504], 'Google': [505, 526, 603, 646, 698, 758, 793, 840, 888, 918, 946, 966, 1015, 1045, 1083, 1124, 1185, 1238, 1397, 1444, 1490, 1807, 1867, 1925, 2074, 2197, 3567, 3838, 3867, 3928, 3977, 4008, 4095, 4268, 4313, 4468, 4540, 4781, 4803, 4843, 4928], 'Scholar,': [506, 604, 647, 759, 794, 889, 947, 1016, 1046, 3839, 3978, 4782, 4804], '2Petersen': [507], 'D.R.': [508, 651], 'Alcohol,': [509], 'iron-associated': [510], 'oxidative': [511, 544, 3351, 3420, 3555, 3792, 3946], 'stress,': [512], 'cancer.Alcohol.': [514], '2005;': [515], '35:': [516], '243-249Abstract': [517], 'Full': [518, 520, 1230, 1232, 1437, 1439, 4260, 4262], 'Text': [519, 521, 1231, 1233, 1438, 1440, 4261, 4263], 'PDF': [522, 1234, 1441, 4264], '(59)': [525], 'Scholar': [527, 699, 841, 919, 967, 1084, 1125, 1186, 1239, 1398, 1445, 1491, 1808, 1868, 1926, 2075, 2198, 3568, 3868, 3929, 4009, 4096, 4269, 4314, 4469, 4541, 4844, 4929], 'ethanol': [529, 584, 619, 1175, 1427, 2483, 4758, 4787], 'increases': [531, 1521, 2750], 'production': [532, 1003, 1528, 2058, 2181, 4164], 'oxygen': [535, 4080], 'species,': [536], 'lowers': [537, 714], 'cellular': [538, 1261, 1285, 2261, 3934, 4386], 'antioxidant': [539, 568, 667, 3402], 'levels,': [540, 988], 'leads': [542, 4294], 'liver.': [548, 3800], 'Alcohol-induced': [549], 'enhanced': [555], 'peroxidation,': [557, 626], 'protein': [558, 590, 629, 1264, 2520, 2978, 2995, 3066, 4587, 4598, 4672, 4675], 'carbonyl': [559], 'radicals,': [564], 'defenses.3Rouach': [569], 'H.': [570, 891, 1157, 1205, 3547, 3551, 3815, 3819, 3841, 3843, 3948, 3986, 4752], 'Fataccioli': [571], 'V.': [572, 3543], 'Gentil': [573], 'M.': [574, 578, 616, 723, 765, 1052, 1201, 1408, 1412, 3982, 4072, 4233, 4503, 4509], 'French': [575], 'S.W.': [576, 606], 'Morimoto': [577], 'Nordmann': [579], 'R.': [580, 649, 767, 3541, 3984], 'Effect': [581, 617, 4785], 'chronic': [583, 1036, 1172], 'feeding': [585, 2466, 2484, 2541, 2823, 4719], 'peroxidation': [588, 664, 718, 852, 874, 3797, 3912, 3992], 'oxidation': [591, 1514], 'relation': [593, 633], 'pathology.Hepatology.': [596], '1997;': [597, 834, 1118, 1179], '25:': [598], '351-355Crossref': [599], '(204)': [602], '4French': [605], 'Wong': [607], 'K.': [608, 4237, 4515], 'Jui': [609], 'L.': [610, 804, 1020, 1457, 1774, 1834, 1892], 'Albano': [611], 'E.': [612, 1050, 1410], 'Hagbjork': [613], 'A.L.': [614], 'Ingelman-Sundberg': [615], 'cytochrome': [621], 'P450': [622], '2E1': [623], '(CYP2E1),': [624], 'serum': [628], 'adduct': [630, 3114, 3169, 3201, 3603, 3636, 3711, 4606, 4618, 4676], 'pathology': [636], 'pathogenesis.Exp': [637], 'Mol': [638], 'Pathol.': [639], '1993;': [640], '58:': [641], '61-75Crossref': [642], '(133)': [645], '5Polavarapu': [648], 'Spitz': [650], 'Sim': [652], 'J.E.': [653], 'Follansbee': [654], 'M.H.': [655, 4239], 'Oberley': [656], 'L.W.': [657], 'Rahemtulla': [658, 799], 'A.': [659, 800, 1018, 1404, 1414, 3980, 4748, 4895, 4897], 'Nanji': [660, 860], 'A.A.': [661, 796, 861], 'impaired': [666, 4251], 'enzyme': [668], 'function': [669, 4588], 'pathological': [673, 4167], 'experimental': [677, 1136, 2925], 'rats': [682, 777], 'diets': [684], 'high': [685, 3939, 4063], 'corn': [687], 'oil': [688], 'fish': [690], 'oil.Hepatology.': [691], '1998;': [692, 1434, 3922], '27:': [693], '1317-1323Crossref': [694], '(280)': [697], 'Replacement': [700], 'polyunsaturated': [702], 'fat': [703, 710, 744, 772, 876, 5013], '(required': [704], 'peroxidation)': [707, 5016], 'saturated': [709, 743, 771, 814, 5012], 'medium-chain': [712], 'triglycerides': [713], 'prevents': [716, 925, 1145, 4517, 4620], 'injury.6You': [722], 'Cao': [724], 'Q.': [725], 'Liang': [726], 'X.': [727, 4754], 'Ajmo': [728], 'J.M.': [729], 'Ness': [730], 'G.C.': [731], 'Mammalian': [732], 'sirtuin': [733], '1': [734, 1956, 2096, 2299, 2972], 'involved': [736, 1531, 2878, 3236, 3289, 3424, 3583, 4968], 'action': [740], 'dietary': [742], 'against': [745, 3412, 3748, 5024], 'fatty': [747, 780, 815, 1518], 'mice.J': [750], 'Nutr.': [751, 786], '2008;': [752, 2068, 2191], '138:': [753], '497-501Crossref': [754], '(83)': [757], '7Ronis': [760], 'M.J.': [761], 'Korourian': [762], 'S.': [763, 806, 808, 895, 899, 901, 931, 949, 1455, 1463, 1772, 1780, 1832, 1840, 1890, 1898, 3545, 3549, 3952, 3956, 3958, 4070, 4287, 4497, 4750], 'Zipperman': [764], 'Hakkak': [766], 'Badger': [768], 'T.M.': [769], 'Dietary': [770, 813], 'reduces': [773, 870], 'altering': [779], 'acid': [781], 'metabolism': [782], 'membrane': [784, 1516, 2835], 'composition.J': [785], '2004;': [787, 960, 1484, 1801, 1861, 1919, 4462], '134:': [788], '904-912Crossref': [789], '(99)': [792], '8Nanji': [795], 'Zakim': [797], 'Daly': [801, 1099], 'T.': [802, 1461, 1778, 1838, 1896, 2052, 2175, 4074], 'Miao': [803], 'Zhao': [805], 'Khwaja': [807], 'Tahan': [809, 3542], 'S.R.': [810], 'Dannenberg': [811], 'A.J.': [812], 'acids': [816], 'down-regulate': [817], 'cyclooxygenase-2': [818], 'factor': [822, 1002, 1064, 1110, 1219, 1373, 1479, 1796, 1856, 1914, 4168, 4523, 4791, 4826], 'alfa': [823], 'reverse': [825, 2036, 2102, 2108], 'fibrosis': [826], 'rat.Hepatology.': [833, 1178], '26:': [835, 1119, 1180], '1538-1545Crossref': [836], '(106)': [839], 'contrast,': [843], 'addition': [845], 'iron,': [847, 872], 'known': [848], 'promote': [850], "Fenton's": [854], 'reaction,': [855], 'exacerbates': [856], 'injury.9Sadrzadeh': [858], 'S.M.': [859], 'Price': [862], 'P.L.': [863], 'The': [864, 932, 1554, 2116, 2283, 2303, 2312, 2333, 2552, 2628, 2764, 2862, 3085, 3534, 3647, 3776, 3801, 4612, 4708, 5019], 'oral': [865], 'iron': [866], 'chelator,': [867], '1,': [868], '2-dimethyl-3-hydroxypyrid-4-one': [869], 'hepatic-free': [871], 'chronically': [879], 'ethanol-fed': [880], 'rats.J': [881], 'Pharmacol': [882, 958], 'Exp': [883, 1075, 3920, 4835], 'Ther.': [884, 959], '1994;': [885], '269:': [886], '632-636PubMed': [887], '10Tsukamoto': [890], 'Horne': [892, 3949], 'W.': [893, 3950, 4285], 'Kamimura': [894, 3951], 'Niemelä': [896], 'O.': [897, 3954], 'Parkkila': [898, 3955], 'Ylä-Herttuala': [900], 'Brittenham': [902, 3959], 'G.M.': [903, 3960], 'Experimental': [904, 3961], 'cirrhosis': [906, 3963], 'induced': [907, 2958, 3964, 4230, 4988], 'iron.J': [911, 3968], 'Clin': [912, 1074, 3919, 3969, 4305, 4834], 'Invest.': [913, 3970, 4306], '1995;': [914, 3861, 3971], '96:': [915, 3972], '620-630Crossref': [916, 3973], 'More': [920], 'important,': [921], 'supplementation': [922, 3618, 3762], 'antioxidants': [924, 5053], 'injury.11Griffith': [928], 'C.M.': [929], 'Schenker': [930], 'nutritional': [935], 'therapy': [936, 5080], 'disease.Alcohol': [940, 3918], 'Res': [941], 'Health.': [942], '2006;': [943, 4837], '296-306PubMed': [945], '12Tome': [948], 'Lucey': [950], 'M.R.': [951], 'Current': [952], 'management': [953], 'disease.Aliment': [957], '19:': [961], '707-714Crossref': [962], '(95)': [965], 'Overproduction': [968], 'contributes': [974, 4330], 'ALD.': [979, 1495, 2426, 3452, 3665, 4161, 4170, 4998, 5018, 5055, 5082], 'Patients': [980], 'hepatitis': [983], 'have': [984, 4419, 4699], 'systemic': [986], 'correlate': [990], 'severity': [993], 'mortality.13McClain': [995], 'C.J.': [996, 1022, 1465, 1782, 1842, 1900, 2054, 2177], 'Cohen': [997], 'D.A.': [998], 'monocytes': [1005], 'hepatitis.Hepatology.': [1008], '1989;': [1009], '9:': [1010, 3562], '349-351Crossref': [1011], '(489)': [1014], '14Khoruts': [1017], 'Stahnke': [1019], 'McClain': [1021, 1464, 1781, 1841, 1899, 2053, 2176], 'Logan': [1023], 'G.': [1024, 4507, 4812, 4899], 'Allen': [1025], 'J.I.': [1026], 'Circulating': [1027], 'factor,': [1030], 'interleukin-1': [1031], 'interleukin-6': [1033], 'concentrations': [1034, 3935], 'patients.Hepatology.': [1038], '1991;': [1039, 3832], '13:': [1040], '267-276Crossref': [1041], '(509)': [1044], '15Felver': [1047], 'M.E.': [1048, 4235], 'Mezey': [1049], 'McGuire': [1051], 'Mitchell': [1053], 'M.C.': [1054], 'Herlong': [1055], 'H.F.': [1056], 'Veech': [1057, 1059], 'G.A.': [1058], 'R.L.': [1060], 'Plasma': [1061], 'alpha': [1065, 1220, 1374], 'predicts': [1066], 'long-term': [1068, 1340, 2495, 2506, 3195, 4692, 4733, 4849, 4878, 4936], 'survival': [1069, 1258], 'severe': [1071], 'hepatitis.Alcohol': [1073], 'Res.': [1076, 3921, 4836], '1990;': [1077], '14:': [1078], '255-259Crossref': [1079], '(267)': [1082], 'Moreover,': [1085, 2475, 2743, 2955, 4270, 4999], 'promoter': [1088, 1111], 'polymorphism': [1089, 1112], 'has': [1090, 4038, 5117], 'been': [1091, 4039, 4420, 4700], 'linked': [1092], 'susceptibility': [1094, 1114], 'hepatitis.16Grove': [1097], 'J.': [1098], 'A.K.': [1100], 'Bassendine': [1101], 'M.F.': [1102], 'Day': [1103], 'C.P.': [1104], 'Association': [1105], 'steatohepatitis.Hepatology.': [1117], '143-146Crossref': [1120], '(252)': [1123], 'Compelling': [1126], 'relating': [1128], 'setting': [1137], "Thurman's": [1139], 'laboratory': [1140], 'indicate': [1141], 'anti-TNF': [1143], 'antibody': [1144, 2271, 2528, 3062], 'rats.17Iimuro': [1150], 'Y.': [1151, 4076], 'Gallucci': [1152, 1208], 'R.M.': [1153, 1209], 'Luster': [1154], 'M.I.': [1155, 1211], 'Kono': [1156, 1204], 'Thurman': [1158, 1212], 'R.G.': [1159, 1213], 'Antibodies': [1160], 'attenuate': [1165], 'inflammation': [1169], 'caused': [1170, 3328], '1530-1537Crossref': [1181], '(449)': [1184], 'Similarly,': [1187], 'lacking': [1189], 'type': [1192, 4429], 'I': [1193, 1275], 'receptor': [1194], 'do': [1195], 'not': [1196, 2492, 2499, 3409, 3423, 4301, 4494], 'develop': [1197], 'injury.18Yin': [1200], 'Wheeler': [1202], 'M.D.': [1203], 'Bradford': [1206], 'B.U.': [1207], 'Luser': [1210], 'Essential': [1214], 'mice.Gastroenterology.': [1226], '1999;': [1227, 4257, 4534, 4797], '117:': [1228], '942-952Abstract': [1229], '(640)': [1237], 'induces': [1241], 'pro-': [1243], 'anti-apoptotic': [1245, 2703, 4383], 'signaling.': [1246], 'activates': [1248, 1297], 'NF-κB,': [1249, 2992], 'inducing': [1250], 'transcription': [1251, 2109], 'target': [1254, 1321], 'genes': [1255], 'primarily': [1256], 'encoding': [1257], 'proteins': [1259, 2989, 3184, 4636], '(eg,': [1260], 'FLICE-like': [1262, 4387], 'inhibitory': [1263, 4388], 'apoptosis': [1268, 2472, 4229, 4296, 4392], 'proteins)': [1269], 'complex': [1274, 1288, 1294, 3136, 4219], 'signalosome': [1276], 'after': [1277, 2149, 2482, 2781, 2914, 2968, 2974, 3080, 3516, 3531, 4297, 4302], 'binding': [1278, 2530, 2831], 'receptor-1.': [1281], 'Depending': [1282], 'signaling': [1286, 1312, 4792], 'context,': [1287], 'II': [1289], 'be': [1291, 2398, 4626], 'formed': [1292], 'I,': [1295], 'caspase-8': [1298], 'pro-apoptotic': [1300], 'pathways.': [1301], 'Activation': [1302], 'caspases': [1304, 4403], 'prolonged': [1306, 3217], 'c-Jun': [1307], 'NH2': [1308], 'terminal': [1309], '(JNK)': [1311], 'are,': [1313], 'under': [1314, 1324, 3225], 'normal': [1315, 1325], 'conditions,': [1316, 1327, 2688], 'antagonized': [1317], 'various': [1319], 'genes.': [1322], 'Therefore,': [1323, 4648], 'physiological': [1326, 2687, 3802, 3852], 'are': [1329, 1354, 1529, 4049, 4276, 4742, 5126, 5146, 5155], 'resistant': [1330, 2692, 4051], 'However,': [1334, 2970], 'several': [1335, 4745], 'laboratories': [1336], 'independently': [1337], 'TNF-mediated': [1346, 3331], 'Subsequent': [1348], 'investigations': [1349, 3704], 'multiple': [1352], 'mechanisms': [1353, 2877, 4582], 'implicated': [1355], 'sensitizing': [1358], 'process,': [1359, 3587], 'including': [1360, 2993, 4348, 4385], 'mitochondrial': [1361, 1388, 1400], 'permeability': [1362, 1389], 'transition': [1363], 'pore': [1364], 'opening,19Pastorino': [1365], 'J.G.': [1366], 'Hock': [1367], 'J.B.': [1368], 'Ethanol': [1369], 'potentiates': [1370, 4760], 'cytotoxicity': [1375, 3750, 4148], 'hepatoma': [1377, 1605], 'cells': [1378, 1965, 2013, 2589, 2624, 2671, 2736, 2758, 3012, 3145, 3241, 3379, 4138, 4182, 4862, 5125], 'primary': [1380, 2673, 2738, 2942, 3147, 4131], 'rat': [1381], 'promoting': [1384], 'induction': [1385, 3349, 4830], 'transition.Hepatology.': [1390], '2000;': [1391], '31:': [1392], '1141-1152Crossref': [1393], '(175)': [1396], '(GSH)': [1402], 'levels,20Colell': [1403], 'Garcia-Ruiz': [1405], 'C.': [1406, 4499], 'Miranda': [1407], 'Ardite': [1409], 'Mari': [1411], 'Morales': [1413], 'Corrales': [1415], 'F.': [1416], 'Kaplowitz': [1417], 'N.': [1418, 4289], 'Fernández-Checa': [1419], 'J.C.': [1420], 'Selective': [1421], 'depletion': [1423], 'mitochondria': [1425], 'factor.Gastroenterology.': [1433], '15:': [1435], '1541-1551Abstract': [1436], '(312)': [1443], 'S-adenosylhomocysteine': [1449, 1466, 1783, 1843, 1901], 'levels,21Song': [1450], 'Z.': [1451, 1453, 1768, 1770, 1828, 1830, 1886, 1888, 2046, 2048, 2169, 2171], 'Zhou': [1452, 1769, 1829, 1887, 2047, 2170], 'Uriarte': [1454, 1771, 1831, 1889], 'Wang': [1456, 1773, 1833, 1891], 'Kang': [1458, 1775, 1835, 1893], 'Y.J.': [1459, 1776, 1836, 1894], 'Chen': [1460, 1777, 1837, 1895, 2051, 2174], 'Barve': [1462, 1779, 1839, 1897], 'TNF-α': [1469, 1786, 1846, 1904], 'cells:': [1475, 1792, 1852, 1910], 'possible': [1477, 1794, 1854, 1912], 'etiological': [1478, 1795, 1855, 1913], 'disease.Hepatology.': [1483, 1800, 1860, 1918, 2067, 2190], '40:': [1485, 1802, 1862, 1920], '989-997Crossref': [1486, 1803, 1863, 1921], '(82)': [1489, 1806, 1866, 1924], 'all': [1492], 'Of': [1496], 'peroxides,': [1498], '4-hydroxynonenal': [1499, 3848], 'aldehydic': [1509], 'products': [1510, 3909], 'derived': [1511], 'n-6-polyunsaturated': [1517], 'acids.': [1519], 'Although': [1520, 4031, 4411, 4688], 'critically': [1530, 3288], 'development': [1535], 'ALD,': [1537, 2799, 3165, 3673, 3883, 5038], 'it': [1538, 4649, 4680], 'remains': [1539, 4624], 'unclear': [1540], 'if': [1541], 'may': [1543, 2573, 3346, 3462, 3936, 4155, 4669, 4852, 5039], 'cell': [1550, 1580, 1606, 2580, 2663, 2695, 2834, 3160, 3223, 3275, 3293, 3414, 3482, 4046, 4085, 4119, 4125, 4409, 4428, 4476, 4722, 4972, 5027, 5144], 'death': [1551, 1581, 1870, 2581, 2607, 2664, 2696, 3224, 3276, 3415, 3483, 4120, 4198], 'hepatocytes.': [1553, 2584, 2675, 3752, 4560], 'conducted': [1558, 2517, 3119], 'test': [1560, 2388], 'this': [1561, 3585, 3650, 4868, 5072], 'hypothesis.': [1562], 'We': [1563, 2585, 5083], 'report': [1564, 4552], 'herein': [1565], 'minimally': [1573], 'toxic': [1574], 'suppression': [1583, 2794, 3009, 3497, 4323, 4962], 'All': [1587, 2363], 'chemicals': [1588], 'obtained': [1590, 1609, 1618, 4316], 'Sigma-Aldrich': [1592], '(St.': [1593], 'Louis,': [1594], 'MO),': [1595], 'unless': [1596], 'otherwise': [1597], 'specified.': [1598], 'HepG2': [1599, 2588, 2623, 2735, 2757, 2940, 3144, 3240, 3278, 3378, 3395, 5124], 'Hep3B': [1601, 2670], 'cells,': [1602, 2086, 3279, 4437, 4885], 'two': [1603], 'lines,': [1607], 'ATCC': [1611], '(Manassas,': [1612], 'VA).': [1613], 'Primary': [1614], 'mouse': [1615, 2674, 2739, 2943, 3148, 3670, 4132], 'Celsis': [1620], 'Vitro': [1622], 'Technologies': [1623], '(Baltimore,': [1624], 'MD).': [1625], 'Hepatocytes': [1626], 'cultured': [1628, 2012, 2085, 2583, 3692], "Dulbecco's": [1630], 'modified': [1631], "Eagle's": [1632], 'medium': [1633], 'containing': [1634], '10%': [1635], '(v/v)': [1636], 'fetal': [1637], 'bovine': [1638], 'serum,': [1639], '2': [1640, 2597, 3258, 3322, 5133], 'mmol/L': [1641, 2242, 2245], 'glutamine,': [1642], 'U/mL': [1644], 'penicillin,': [1645], '50': [1647, 2244, 2318], 'μg/mL': [1648], 'streptomycin': [1649], '37°C': [1651], 'humidified': [1654], 'O2/CO2': [1655], '(19:1)': [1656], 'atmosphere.': [1657], '(Jackson': [1661], 'Laboratory,': [1662], 'Bar': [1663], 'Harbor,': [1664], 'ME),': [1665], 'weighing': [1666], '25': [1667], '±': [1668, 1672, 2369], '0.5': [1669, 3314], 'g': [1670], '(mean': [1671], 'SD)': [1673], 'ad': [1676], 'libitum': [1677], 'Lieber-DeCarli': [1681, 2413], '(ethanol-derived': [1683], 'calories': [1684], '30%': [1688], '36%': [1690], 'during': [1691, 2922, 4221, 4793, 5103], 'first': [1693, 2586, 2889, 4550], '4': [1694, 2723], 'weeks,': [1695, 2419], '2%': [1698], 'increase': [1699, 2436, 2919, 3708, 3871, 4943], 'each': [1700, 1946, 2094], 'week)': [1701], 'isocaloric': [1704], 'liquid': [1706, 2415], '(Bioserv,': [1708], 'Frenchtown,': [1709], 'NJ)': [1710], 'For': [1714, 1927, 2093], 'N-acetylcysteine': [1715, 3552], '(NAC)': [1716], 'supplementation,': [1717], 'NAC': [1718, 3535, 3617, 3761, 5022], 'added': [1720, 1944], 'into': [1721], 'dose': [1727, 2746], '0.16': [1729], 'mg/mL.': [1730], 'Food': [1731], 'intake': [1732, 4815], 'body': [1734], 'weight': [1735], 'recorded': [1737], 'daily': [1738], 'weekly,': [1740], 'respectively.': [1741], 'Mice': [1742, 4206], 'euthanized,': [1744], 'plasma': [1746, 2451, 3807, 3879], 'samples': [1749], 'harvested': [1751], 'end': [1754, 1934], 'experiment.': [1757], 'H&E': [1758], 'staining': [1759, 2653], 'sections': [1762], 'performed': [1764, 2042, 2165, 2374], 'previously': [1766, 1826, 1884, 2044, 2167], 'described.21Song': [1767, 1827, 1885], 'Apoptotic': [1809], 'detected': [1812, 4609], 'TUNEL': [1814, 1818, 2461], 'kit': [1820, 2110], '(Intergen': [1821], 'Company,': [1822], 'Purchase,': [1823], 'NY),': [1824], 'determined': [1872, 3046], 'measurement': [1874], 'lactate': [1876], 'dehydrogenase': [1877], '(LDH)': [1878], 'release': [1879], 'MTT': [1881, 2614], 'assay,': [1882], 'Hoechst': [1928, 1942, 2651], 'staining,': [1929], '30': [1930, 2966], 'minutes': [1931, 2913, 2967, 3079], 'before': [1932, 2599, 3260], 'incubation': [1937], 'indicated': [1940, 3018], 'stimulus,': [1941], 'well': [1947], '24-well': [1949], 'plates': [1950, 2125], 'final': [1953], 'concentration': [1954, 3803], 'μmol/L.': [1957], 'At': [1958], 'completion': [1960], 'incubation,': [1963], 'washed': [1967, 2306, 2313], 'three': [1968], 'times': [1969, 2308, 2322], 'ice-cold': [1971], 'PBS,': [1972], 'then': [1974], 'fluorescence': [1976, 2647], 'measured': [1978, 2015, 2609, 3167, 3374, 3512, 3598], 'fluorescent': [1980], 'microscope': [1981], 'emission': [1984], 'wavelength': [1985, 1992], '460': [1987], 'nm,': [1988], 'using': [1989, 2016, 2104, 2359, 2375, 2524, 2634, 3060, 3179, 3667, 3691], 'excitation': [1991], '360': [1994], 'nm': [1995], 'dichlorofluorescein': [1998], 'fluorophore.': [1999], '(p65)': [2001, 2753, 2814, 3173], 'DNA-binding': [2002, 2754, 2810, 2828, 4374], 'activity': [2003, 2454, 2755, 2811, 4698, 4856], 'nuclear': [2006, 2801, 2826, 2860, 2950, 3171, 3181, 3210, 4367, 4824], 'fraction': [2007, 2802], 'tissues': [2010, 2807], 'enzyme-linked': [2017], 'immunosorbent': [2018], '(ELISA)': [2020], 'kits': [2021], '(Cayman': [2022], 'Chemical,': [2023], 'Ann': [2024], 'Arbor,': [2025], 'MI),': [2026], 'accordance': [2028], "manufacturer's": [2031], 'instructions.': [2032], 'Total': [2033, 2260], 'RNA': [2034, 2100], 'isolation,': [2035], 'transcription,': [2037], 'real-time': [2039], 'PCR': [2040, 2130], 'described.22Song': [2045], 'Deaciuc': [2049, 2172], 'I.': [2050, 2173], 'Inhibition': [2055, 2178], 'adiponectin': [2057, 2180], 'homocysteine:': [2060, 2183], 'mechanism': [2063, 2186, 4614], '47:': [2069, 2192], '867-879Crossref': [2070, 2193], '(110)': [2073, 2196], 'Briefly,': [2076], 'total': [2077, 2099], 'RNA,': [2078], 'either': [2080, 3180, 4402], 'frozen': [2081], 'tissue': [2083], 'isolated': [2088, 2804], 'phenol-chloroform': [2091], 'extraction.': [2092], 'sample,': [2095], 'μg': [2097, 2264], 'transcribed': [2103], 'high-capacity': [2106], 'cDNA': [2107, 2117], '(Applied': [2111, 2133, 2142], 'Biosystems,': [2112], 'Foster': [2113], 'City,': [2114], 'CA).': [2115], 'amplified': [2119], 'MicroAmp': [2121], 'Optical': [2122], '96-well': [2123], 'reaction': [2124], 'SYBR': [2128], 'Green': [2129], 'Master': [2131], 'Mix': [2132], 'Biosystems)': [2134], 'Prism': [2137], '7000': [2138], 'sequence': [2139], 'detection': [2140], 'system': [2141], 'Biosystems).': [2143], 'Relative': [2144], 'gene': [2145, 2154, 2779, 4379], 'expression': [2146, 2780, 2987, 4380, 4524], 'calculated': [2148], 'nomalization': [2150], 'housekeeping': [2153], '(mouse': [2155], '18S': [2158], 'ribosomal': [2159], 'RNA).': [2160], 'Western': [2161, 2360, 2513, 2635, 3057], 'blot': [2162, 2361, 2514, 2636, 3058], 'analysis': [2163, 2372, 2378, 2515, 2637, 3059, 3117], 'described,22Song': [2168], 'following': [2201, 2842], 'antibodies': [2202], 'used:': [2204], 'anti-poly': [2205], '(ADP-ribose)': [2206, 2644], 'polymerase': [2207], '(Novus': [2208], 'Biologicals,': [2209], 'Littleton,': [2210], 'CO),': [2211], 'anti-4-HNE': [2212], '(R&D': [2213], 'Systems,': [2214], 'Inc.,': [2215], 'Minneapolis,': [2216], 'MN),': [2217], 'anti-phospho-IκBα,': [2218], 'anti-IκBα,': [2219], 'anti-phosphorylated-IκB': [2220], '(IKKβ),': [2222], 'anti-IKKβ,': [2223], 'anti-ubiquitin,': [2224], 'anti-p65,': [2225], 'anti-phosphorylated-JNK,': [2226], 'anti-JNK': [2228], '(Cell': [2229], 'Signaling': [2230], 'Technology,': [2231], 'Danvers,': [2232], 'MA).': [2233], 'Cells': [2234], 'lysed': [2236], 'buffer': [2240, 2276, 2325], '(150': [2241], 'NaCl,': [2243], 'Tris-HCl,': [2246], '1%': [2248], 'Nonidet': [2249], 'P-40,': [2250], 'pH': [2251], '7.8)': [2252], 'mammalian': [2255], 'cell-specific': [2256], 'protease': [2257], 'cocktail.': [2259], 'extracts': [2262], '(200': [2263], 'protein)': [2266], 'incubated': [2268, 2316], 'anti-IκBα': [2270], '(1': [2272], 'μg/mL)': [2273], 'overnight': [2277], '4°C': [2279], 'rocker.': [2282], 'antibody-protein': [2284], 'mixture': [2285], 'agitated': [2287], 'Protein': [2289], 'A/G': [2290], 'agarose': [2291], '(Santa': [2292], 'Cruz': [2293], 'Biotechnology,': [2294], 'Santa': [2295], 'Cruz,': [2296], 'CA)': [2297], 'hour': [2300, 2973], '4°C.': [2302], 'immunoprecipitates': [2304, 2314], 'four': [2307], 'buffer.': [2311], 'μL': [2319], 'electrophoresis': [2323], 'loading': [2324], 'heated': [2327], '100°C': [2329], 'minutes.': [2332, 5142], 'beads': [2334], 'spun': [2336], 'out': [2337], 'supernatant': [2340], 'resolved': [2342], 'SDS-PAGE,': [2344], 'modification': [2347, 2521, 3123], 'IκBα': [2349, 2355, 2845, 2854, 2865, 2910, 2936, 2962, 2977, 2994, 3005, 3027, 3038, 3049, 3125, 3135, 3176, 3205, 3606, 3642, 3728, 4275, 4485, 4571, 4671], 'ubiquitination': [2353, 2850], 'analyzed': [2357, 2385], 'analysis.': [2362], 'expressed': [2366, 5156], 'mean': [2368], 'SD.': [2370], 'Statistical': [2371], 'one-way': [2377], 'variance,': [2380], 'further': [2384, 2631, 2773, 3000, 3088, 3296, 5075], 'Newman-Keuls': [2387], 'statistical': [2390], 'differences.': [2391], 'Differences': [2392], 'between': [2393, 4195, 4983], 'treatments': [2394], 'considered': [2396], 'statistically': [2399], 'significant': [2400, 2435, 3707], 'P': [2402], '<': [2403, 5170], '0.05.': [2404], '(aged': [2408], '8': [2409], 'weeks),': [2410], 'alcohol-containing': [2414, 3590], 'used': [2421, 4023], 'model': [2424, 3671, 4715], 'Compared': [2427], 'pair-fed': [2429, 2457, 2550], 'animals,': [2430], 'showed': [2433, 2463, 3067, 3611], 'triglyceride': [2439], '(Figure': [2441, 2446, 2459, 2473, 2485, 2654, 2741, 2759, 2784, 2953, 3013, 3083, 3334, 3416, 3500, 3622, 3632, 3638, 3645], '1A)': [2442], 'steatosis': [2445, 4919], '1B).': [2447], 'Alcohol': [2448, 4171], 'elevated': [2450, 4187], 'alanine': [2452], 'aminotransferase': [2453], 'compared': [2455, 2548, 3150, 3613], 'animals': [2458], '1C).': [2460], 'assays': [2462], 'hepatocyte': [2471, 3292, 4084, 4124, 4228, 4971, 5026], '1D).': [2474], 'levels': [2478, 2490, 2564, 2728, 2979, 3312, 3320, 3376, 3393, 3515, 3874], 'significantly': [2480, 2542, 2776, 3138, 3485, 3525, 5168], '1E),': [2486], 'whereas': [2487, 4470, 4886], 'circulating': [2488, 3908], 'affected': [2493, 2710, 3506], '(data': [2498], 'shown).': [2500], 'To': [2501, 2659, 2786, 2874, 3103, 3154, 3232, 3358, 3453, 3502, 3569, 4542], 'determine': [2502, 2570, 2660, 2787, 2875, 3104, 3155, 3233, 3359, 3454, 3503, 3570, 3654], 'consumption': [2508, 4880, 4938], 'contents,': [2512, 3174], 'detect': [2519], 'polyclonal': [2526], 'anti–4-HNE': [2527], 'specifically': [2529], '4-HNE–modified': [2532, 3134], 'proteins.': [2533, 2704], 'As': [2534, 2616, 2676, 2714, 2817, 2901, 3128, 3190, 3264, 3383, 3476, 3519], 'shown': [2535, 2617, 2677, 2715, 2818, 2902, 3129, 3191, 3265, 3384, 3477, 3520, 5070], 'Figure': [2537, 2619, 2679, 2717, 2820, 2904, 3099, 3131, 3193, 3267, 3386, 3479, 3522, 5115], '1F,': [2538], '5-week': [2539], 'when': [2547], 'association': [2553], 'elevation': [2558, 2934, 4952], 'made': [2568], 'us': [2569], 'whether': [2571, 2708, 3047, 3105, 3156, 3360, 3455, 3504, 3571, 3655], 'act': [2574, 4569], 'pretreated': [2587, 3243, 5127], '(0': [2592, 2601], '60': [2594, 4018], 'μmol/L)': [2595, 3326], 'hours': [2598, 2611, 2724, 3259, 3315], '40': [2603, 4109], 'ng/mL)': [2604, 5139], 'stimulation.': [2605, 4205], '16': [2610], 'later': [2612], 'assay.': [2615], '2A,': [2620], 'killing.': [2627, 4338, 4960], 'conclusion': [2629, 3086, 4340], 'confirmed': [2632, 3089], 'cleaved': [2640], 'form': [2641], 'poly': [2643], 'polymerase-1': [2645], 'microscopic': [2648], 'examination': [2649, 3297], '33342': [2652], '2,': [2655], 'B': [2656, 2761, 4828], 'C).': [2658, 2763], 'generality,': [2662], 'repeated': [2667], '1D,': [2680], 'comparable': [2682], 'results': [2683, 3016, 3610, 4423, 4703, 4939], 'observed.': [2685], 'Under': [2686], 'because': [2697, 4059], 'NF-κB–mediated': [2699, 2778], 'transcriptional': [2700], 'regulation': [2701, 4913], 'We,': [2705], 'therefore,': [2706], '3,': [2718, 2760], 'dose-dependent': [2731], 'manner': [2732], '3A).': [2742], 'pretreatment': [2745, 3070, 3327, 3398, 4353], 'dependently': [2747], 'suppressive': [2765, 2881], 'transactivity': [2771, 3023], 'corroborated': [2774], 'stimulation': [2783, 2907, 2957, 3041, 3302], '3D).': [2785], 'vivo': [2790, 4027], 'relevance': [2791], '4-HNE–induced': [2793, 3361, 3426, 4144], 'activation': [2797, 3215, 3219, 3286, 3333, 3581, 4253, 4327, 4406, 4418, 4482, 4519, 4558, 4888, 4965], 'measured.': [2816], '3E,': [2821], 'p65': [2827, 2951, 3211, 4210, 4368, 4373], 'After': [2830], 'receptor,': [2836], 'activated': [2838, 4439, 4881], 'order:': [2843], 'i)': [2844, 4351], 'IKK,': [2848, 4656], 'ii)': [2849, 4364], 'degradation': [2852, 2963, 4068], '26S': [2856], 'proteasome,': [2857], 'iii)': [2859, 4370], 'translocation.': [2861], 'obligatory': [2868, 4359], 'step': [2869, 4360], 'these': [2871, 3468, 4137], 'subsequent': [2872, 3795, 4530], 'events.': [2873], 'activation,': [2887, 3309, 5063], 'examined': [2890], 'time': [2892], 'course': [2893], 'IκBα.': [2900], '4A,': [2905], 'quickly': [2908], '(15': [2912, 2964], 'exposure),': [2916], 'maintained': [2921], '1-hour': [2924], 'period.': [2926], 'Pretreatment': [2927], 'almost': [2930], 'completely': [2931], 'abolished': [2932], 'hepatocytes,': [2944, 3043, 3693, 4133], '4B).': [2954], 'rapid': [2959, 3305], 'transient': [2961, 3307], 'TNF).': [2969], 'exposure,': [2976], 'higher': [2981], 'than': [2982], 'control,': [2983], 'suggestive': [2984], 'targeted': [2990], 'itself.': [2996], 'This': [2997, 4339], 'supported': [3001, 4342, 4871], 'time-matched': [3004], 'decrease': [3006], '4-HNE–pretreated': [3011], '4A).': [3014], 'collectively': [3017], 'inhibition': [3025, 3369, 4291, 4822], 'phosphorylation.': [3028, 3056], 'Because': [3029], 'IKKβ': [3030, 3055, 3075, 3096, 5122], 'dominant': [3033], 'phosphorylate': [3037], 'next': [3045, 3511], 'due': [3052], 'altered': [3054], 'phosphorylated': [3064, 3095, 4685], 'IKKα/β': [3065], 'had': [3071], 'no': [3072, 5118], '15': [3078, 5141], 'simulation': [3082], '4C).': [3084], 'ELISA': [3092, 5151], 'specific': [3093, 3254], '(see': [3097], 'Supplemental': [3098, 5114], 'S1': [3100], 'http://ajp.amjpathol.org).': [3102], 'exogenous': [3108, 4020], 'led': [3110, 3303], '4-HNE–IκBα': [3113, 3168, 3200, 3602, 3635, 3710, 4605, 4617], 'evaluate': [3121], '4-HNE.': [3127, 3382], '4D,': [3132], 'untreated': [3152, 5160], 'cells.': [3153, 3396, 5162], 'our': [3157, 4099, 4543, 4602, 4932], 'observations': [3158, 4741], 'status': [3178, 3644], 'cytosolic': [3183], 'pair-': [3186], '4E,': [3194], 'content,': [3202, 3601, 4949], 'phosphorylation,': [3206, 3729], 'contents.': [3212], 'Both': [3213], 'caspase': [3214, 3283, 4770], 'JNK': [3218, 3255, 3285, 3308, 3332, 4405], 'contributed': [3220], 'conditions': [3227], 'inhibited': [3229, 4354], 'pathways': [3235], '4-HNE/TNF-induced': [3238, 3291, 3413, 3481, 3749, 4408, 4970, 5025], 'cytotoxicity,': [3239], '10': [3245], 'μmol/L': [3246, 3942, 4019, 4110], 'Z-VAD-FMK,': [3247], 'pan-caspase': [3249], 'inhibitor,': [3250, 3256], 'SP600125,': [3252], '4-HNE/TNF.': [3263], '5,': [3268], 'A': [3269, 3295, 3869], 'B,': [3271], 'inhibitors': [3273, 4400], 'alleviated': [3274, 3495], 'indicating': [3280], 'death.': [3294, 4410, 4973], 'that,': [3299, 3612], 'although': [3300], 'reaching': [3310], 'peak': [3311], 'returning': [3317], 'basal': [3319], 'hours,': [3323, 5134], '(40': [3325, 5138], 'sustained': [3330], '5C).': [3335], 'Many': [3336], 'previous': [3337, 4422, 4746], 'suggested': [3339], 'deleterious': [3342], 'result': [3347, 3463, 4225], 'GSH': [3356, 3375, 3392, 3406], 'sensitization': [3362, 3427, 4145], 'cytotoxity': [3365], 'mediated': [3367], 'GSH,': [3372], 'exposed': [3380], '6A,': [3387], 'unexpectedly': [3389], 'Furthermore,': [3397], 'NAC,': [3400], 'serving': [3403], 'did': [3408], 'confer': [3410], 'protection': [3411], '6B),': [3417], 'confirming': [3418], '(PPARα)': [3442], 'activity,': [3443], 'PPARα': [3445, 3460, 3742, 5062], 'agonists': [3446, 3461], 'beneficial': [3449, 3457, 3758], 'ability': [3466], 'compounds': [3469], 'metabolize': [3471], 'bezafibrate': [3473, 3488, 3505, 3517, 3524], 'used.': [3475, 3593], '6C,': [3480], '(100': [3489], 'μmol/L),': [3490], 'p65–DNA-binding': [3496], '6D).': [3501], 'metabolism,': [3509], 'treatment.': [3518], '6E,': [3523], 'reduced': [3526, 4378], 'exposure.': [3533], 'injury.23Ozaras': [3540], 'Aydin': [3544], 'Uzun': [3546], 'Kaya': [3548], 'Senturk': [3550], 'attenuates': [3553, 4818], 'stess': [3556], 'rats.World': [3558], 'J': [3559], 'Gastroenterol.': [3560], '2003;': [3561], '791-794Crossref': [3563], '(67)': [3566], 'prevention': [3572], 'improvement': [3578], 'NAC-supplemented': [3589], 'Five': [3594], 'weeks': [3595], 'later,': [3596], 'status.': [3608], 'Our': [3609, 4974], 'attenuated': [3619, 4407], '7A),': [3623], 'lowered': [3628], '7B),': [3633], '7C),': [3639], '7D).': [3646], 'goal': [3648], 'study': [3651, 4320, 4547, 4875, 4933, 5001], 'synergistically': [3659], 'contribute': [3660], 'By': [3666, 3690, 3735], 'well-established': [3669, 5008], 'found': [3675, 3876], 'accompanied': [3681], 'production.': [3689, 4189], 'Mechanistic': [3703], 'leading': [3730, 4185], 'preventing': [3736, 4679], 'accumulation,': [3739, 5068], 'Finally,': [3753], 'ALD': [3764, 4029], 'major': [3780, 4581], 'site': [3781], 'metabolism.': [3784], 'reported': [3809], '0.3': [3811], '0.7': [3813], 'μmol/L.24Esterbauer': [3814], 'Schaur': [3816, 3844], 'R.J.': [3817, 3845], 'Zollner': [3818], 'Chemistry': [3820], 'biochemistry': [3822], '4-hydroxynonenal,': [3824], 'malonaldehyde': [3825], 'related': [3827], 'aldehydes.Free': [3828], 'Radic': [3829, 4459], 'Biol': [3830, 4460, 4532, 4773], 'Med.': [3831, 4461], '11:': [3833, 3862], '81-128Crossref': [3834], '(5936)': [3837], '25Strohmaier': [3840], 'Hinghofer-Szalkay': [3842], 'Detection': [3846], '(HNE)': [3849], 'component': [3853], 'plasma.J': [3856], 'Lipid': [3857], 'Mediat': [3858], 'Signal.': [3860], '51-61Crossref': [3863], '(84)': [3866], 'striking': [3870], 'patients': [3881, 3914], 'ranging': [3884], '2.8-fold': [3886], 'early': [3889], 'stage': [3890], 'insult': [3893], '8.4-fold': [3895], 'cirrhotic': [3898], 'stage.26Aleynik': [3899], 'S.I.': [3900], 'Leo': [3901], 'M.A.': [3902], 'Aleynik': [3903], 'M.K.': [3904], 'Lieber': [3905], 'C.S.': [3906], '22:': [3923], '192-196Crossref': [3924], '(98)': [3927], 'liver,': [3932], 'local': [3933], 'reach': [3937], '≥100': [3941], 'response': [3944, 4202], 'stress.27Tsukamoto': [3947], 'Niemela': [3953], 'Yla-Herttuala': [3957], '(452)': [3976], '28Benedetti': [3979], 'Comporti': [3981], 'Fulceri': [3983], 'Esterbauer': [3985], 'Cytotoxic': [3987], 'aldehydes': [3988], 'originating': [3989], 'microsomal': [3995], 'lipids:': [3996], 'identification': [3997], '4,5-dihydroxydecenal.Biochim': [3999], 'Biophys': [4000], 'Acta.': [4001], '1984;': [4002], '792:': [4003], '172-181Crossref': [4004], '(146)': [4007], 'vitro': [4014, 4101], '20': [4016, 4107], 'mimic': [4025], 'early-stage': [4028], 'direct': [4033], 'cytotoxic': [4034], 'extensively': [4040], 'documented': [4041], 'variety': [4044], 'types,': [4047], 'relatively': [4050, 4062], 'even': [4054], 'pathophysiological': [4056], 'likely': [4058], 'capacity': [4064], 'system.29Sakuma': [4069], 'Negoro': [4071], 'Kitamura': [4073], 'Fujimoto': [4075], 'Xanthine': [4077], 'oxidase-derived': [4078], 'species': [4081], 'mediate': [4082], '4-oxo-2-nonenal-induced': [4083], 'death.Toxicol': [4086], 'Appl': [4087], 'Pharmacol.': [4088], '2010;': [4089], '249:': [4090], '127-131Crossref': [4091], '(16)': [4094], 'Data': [4097, 4315, 5154], 'experiments': [4102], 'show': [4103], 'resulted': [4111], 'zero': [4114], 'minimal': [4116], 'degree': [4117], 'lines': [4126], '(HepG2': [4127], 'Hep3B)': [4129], 'but': [4134, 4300, 4493], 'markedly': [4135], 'suggesting': [4142], 'process': [4153, 4596, 4623], 'account': [4156], 'Dysregulated': [4162], 'causes': [4172], 'gut': [4174], 'permeability,': [4175], 'followed': [4176, 5135], 'Kupffer': [4181, 4861, 4884], 'lipopolysaccharide,': [4184, 4489], 'master': [4193], 'switch': [4194], 'life': [4196], 'deficient': [4207], 'subunit': [4212], 'essential': [4214, 4903], 'components': [4215], 'IKK': [4218, 4562], 'die': [4220], 'midgestation': [4222], 'massive': [4227], 'TNF.30Tanaka': [4232], 'Fuentes': [4234], 'Yamaguchi': [4236], 'Durnin': [4238], 'Dalrymple': [4240], 'S.A.': [4241], 'Hardy': [4242], 'K.L.': [4243], 'Goeddel': [4244], 'D.V.': [4245], 'Embryonic': [4246], 'lethality,': [4247], 'degeneration,': [4249], 'IKK-β-deficient': [4255], 'mice.Immunity.': [4256], '10:': [4258], '421-429Abstract': [4259], '(495)': [4267], 'mutant': [4274], 'sensitive': [4277], 'killing.31Chaisson': [4280], 'M.L.': [4281], 'Brooling': [4282], 'J.T.': [4283], 'Ladiges': [4284], 'Tsai': [4286], 'Fausto': [4288], 'Hepatocyte-specific': [4290], 'treatment,': [4299], 'partial': [4303], 'hepatectomy.J': [4304], '2002;': [4307, 4775], '110:': [4308], '193-202Crossref': [4309], '(172)': [4312], 'current': [4319, 4546], 'suggest': [4321], 'sensitivity': [4333], 'series': [4345], 'observations,': [4347], 'following:': [4350], 'IκBα,': [4357], 'activation;': [4363], 'content;': [4369], 'activity;': [4375], 'iv)': [4376], 'NF-κB–targeted': [4382], 'molecules,': [4384], 'protein,': [4389], 'proteins-1,': [4393], 'manganese': [4395], 'superoxide': [4396], 'dismutase;': [4397], 'v)': [4399], 'reported,': [4421, 4701], 'inconsistent': [4425, 4705], 'obviously': [4427], 'stimulus': [4431], 'dependent.': [4432], 'vascular': [4434], 'smooth': [4435], 'muscle': [4436], 'NF-κB,32Lee': [4440], 'J.Y.': [4441], 'Je': [4442], 'J.H.': [4443], 'Jung': [4444], 'K.J.': [4445], 'Yu': [4446], 'B.P.': [4447], 'Chung': [4448], 'H.Y.': [4449], 'Induction': [4450], 'endothelial': [4452], 'iNOS': [4453], '4-hydroxyhexenal': [4455], 'through': [4456, 4590], 'activation.Free': [4458], '37:': [4463], '539-548Crossref': [4464], '(45)': [4467], 'acute': [4473], 'monocytic': [4474], 'leukemia': [4475], 'line': [4477], 'monocytes,': [4478], 'inhibiting': [4484, 4526, 4765], 'stimulated': [4487], 'IL-1β,': [4490], 'phorbol-12-myristate-13-acetate,': [4492], 'TNF.33Page': [4496], 'Fischer': [4498], 'Baumgartner': [4500], 'B.': [4501, 4810], 'Haas': [4502], 'Kreusel': [4504], 'U.': [4505], 'Loidl': [4506], 'Hayn': [4508], 'Ziegler-Heitbrock': [4510], 'H.W.': [4511], 'Neumeier': [4512], 'Brand': [4514], 'proteolysis.J': [4531], 'Chem.': [4533, 4774], '274:': [4535], '11611-11618Crossref': [4536], '(150)': [4539], 'knowledge,': [4544], 'suppresses': [4555], 'TNF-stimulated': [4556], 'Unchanged': [4561], 'indicates': [4564], 'could': [4567, 4710], 'directly': [4568], 'prevent': [4573], 'IKK.': [4577, 4687], 'One': [4578, 4664], 'affect': [4586], '4-HNE–protein': [4593], 'adducts,': [4594], 'called': [4597], 'carbonylation.': [4599], 'Indeed,': [4600], 'immunoprecipitation.': [4611], 'exact': [4613], 'underlying': [4615], 'how': [4616], 'fully': [4627], 'elucidated.': [4628], 'general,': [4630], 'forms': [4632], 'stable': [4633], 'adducts': [4634], 'reacting': [4638], 'amino': [4640], 'acids,': [4641], 'such': [4642], 'cysteine,': [4644], 'lysine,': [4645], 'histidine.': [4647], 'unlikely': [4651], 'competes': [4654], 'phosphorylates': [4658], 'serine,': [4659], 'sites.': [4663], 'possibility': [4665], 'alter': [4670], 'conformation': [4673], 'thereby': [4678], 'being': [4682], 'accessed': [4683], 'controversial.': [4707], 'discrepancy': [4709], 'derive': [4711], 'differences': [4713], 'selection,': [4716], 'concentration,': [4718], 'duration,': [4720], 'types': [4723], 'studied.': [4724], 'clearly': [4730], 'demonstrate': [4731], 'decreases': [4736], 'consistent': [4743], 'studies.34Koteish': [4747], 'Yang': [4749], 'Lin': [4751], 'Huang': [4753], 'Diehl': [4755], 'A.M.': [4756, 4784], 'Chronic': [4757], 'lipopolysaccharide': [4761], 'despite': [4764], 'Jun': [4766], 'N-terminal': [4767], '3': [4771], 'activation.J': [4772], '277:': [4776], '13037-13044Crossref': [4777], '(79)': [4780], '35Diehl': [4783], 'regeneration.Clin': [4795], 'Biochem.': [4796], '32:': [4798], '571-578Crossref': [4799], '(34)': [4802], '36Mandrekar': [4805], 'P.': [4806, 4893], 'Catalano': [4807, 4900], 'White': [4809], 'Szabo': [4811, 4898], 'Moderate': [4813], 'humans': [4817], 'monocyte': [4819, 4906], 'inflammatory': [4820], 'responses:': [4821], 'regulatory': [4825], 'kappa': [4827], 'interleukin': [4832], '10.Alcohol': [4833], '30:': [4838], '135-139Crossref': [4839], '(119)': [4842], 'It': [4845], 'conceivable': [4847], 'differentially': [4853], 'regulate': [4854], '(inhibition)': [4859], '(activation': [4863], 'lipopolysaccharide).': [4865], 'fact,': [4867], 'recent': [4874], 'demonstrating': [4876], 'inhibited.37Mandrekar': [4892], 'Ambade': [4894], 'Lim': [4896], 'chemoattractant': [4907], 'protein-1': [4908], 'injury:': [4912], 'proinflammatory': [4915], 'cytokines': [4916], 'mice.Hepatology.': [4921], '2011;': [4922], '54:': [4923], '2185-2197Crossref': [4924], '(203)': [4927], 'demonstrates': [4934], 'concomitant': [4942], '4-HNE–mediated': [4961], 'mechanistically': [4967], 'provide': [4976], 'important': [4977], 'new': [4978], 'information': [4979], 'concerning': [4980], 'interactions': [4982], 'peroxides': [4985], 'TNF-': [4987], 'critical': [4992], 'involvement': [4993], 'also': [5002], 'provides': [5003], 'indirect': [5004], 'evidence': [5005], 'explaining': [5006], '(resistant': [5014], 'inability': [5020], 'protecting': [5023], 'death,': [5028], 'along': [5029], 'preventive': [5032, 5048], 'animal': [5035], 'models': [5036], 'partially': [5040], 'explain': [5041], 'clinical': [5043], 'controversies': [5044], 'terms': [5046], 'versus': [5049], 'Together': [5056], 'many': [5058], 'other': [5059], 'hepatoprotective': [5060], 'effects,': [5061], 'reducing': [5065], 'deserves': [5074], 'thank': [5084], 'Drs.': [5085], 'Alan': [5086], 'Diamond': [5087], 'Giamila': [5089], 'Fantuzzi': [5090], '(University': [5091], 'Illinois': [5093], 'Chicago)': [5095], 'their': [5097], 'technical': [5098], 'great': [5101], 'assistance': [5102], 'manuscript': [5104], 'preparation.': [5105], 'Download': [5106], '.pdf': [5107], '(.02': [5108], 'MB)': [5109], 'Help': [5110], 'pdf': [5112], 'files': [5113], 'S14-HNE': [5116], '(20': [5130], 'μM)': [5131], 'Whole': [5143], 'lysates': [5145], 'collected': [5147], 'subjected': [5149], 'p-IKKβ.': [5153], 'fold': [5158], '(UT)': [5161], 'Bars': [5163], 'different': [5165], 'characters': [5166], 'differ': [5167], '(P': [5169], '0.05).': [5171], 'H': [5172], '+': [5173], 'T,': [5174], '4-HNE+TNF.': [5175]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2020117421', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}], 'updated_date': '2024-12-24T15:26:04.242675', 'created_date': '2016-06-24'}