Publication Information

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'https://openalex.org/W2106456872', 'https://openalex.org/W2145376471', 'https://openalex.org/W2168988535', 'https://openalex.org/W2303629570', 'https://openalex.org/W7952702'], 'related_works': ['https://openalex.org/W4386317212', 'https://openalex.org/W4200460130', 'https://openalex.org/W2320472437', 'https://openalex.org/W2171167058', 'https://openalex.org/W2130446470', 'https://openalex.org/W2117675164', 'https://openalex.org/W2104908006', 'https://openalex.org/W2100764580', 'https://openalex.org/W1980410422', 'https://openalex.org/W1906327586'], 'abstract_inverted_index': {'Bilirubin,': [0, 195, 405, 1765], 'the': [1, 11, 15, 25, 42, 85, 120, 176, 182, 196, 206, 210, 220, 237, 280, 315, 371, 377, 406, 414, 444, 463, 494, 556, 649, 978, 1255, 1370, 1393, 1406, 1422, 1430, 1435, 1444, 1449, 1554, 1558, 1579, 1587, 1590, 1610, 1621, 1700, 1706, 1711, 1717, 1725, 1734, 1740, 1754, 1760, 1766, 1774, 1804, 1823, 1854, 1916, 2009, 2338, 2615, 2730, 2753, 2767, 2783, 2791, 2796, 2805, 2810, 2915, 2919, 2940, 2948, 2951, 2971, 2982, 3061, 3067, 3072, 3078, 3086, 3095, 3101, 3115, 3121, 3135, 3151, 3159, 3164, 3173, 3178, 3283, 3287, 3308, 3316, 3319, 3339, 3350, 3430, 3436, 3441, 3447, 3455, 3464, 3470, 3484, 3490, 3508, 3544, 3564, 3583], 'end': [2, 197, 415, 1775], 'product': [3, 198, 416, 1776], 'of': [4, 27, 60, 69, 78, 87, 136, 157, 178, 185, 199, 222, 255, 264, 273, 282, 331, 352, 373, 380, 417, 559, 625, 662, 702, 790, 801, 808, 921, 970, 980, 1047, 1096, 1258, 1311, 1357, 1372, 1384, 1401, 1409, 1425, 1563, 1676, 1708, 1722, 1728, 1733, 1739, 1757, 1777, 1919, 1985, 2022, 2062, 2150, 2161, 2168, 2281, 2330, 2340, 2407, 2456, 2618, 2671, 2717, 2732, 2744, 2762, 2770, 2786, 2924, 3037, 3069, 3083, 3089, 3094, 3100, 3118, 3130, 3138, 3154, 3292, 3406, 3438, 3452, 3458, 3463, 3469, 3487, 3507, 3521, 3524, 3533, 3536, 3546, 3556, 3566, 3574, 3582], 'heme': [5, 200, 418, 1778], 'catabolism,': [6, 201], 'is': [7, 202, 413, 448, 487, 694, 1017, 1412, 1441, 1575, 1744, 1773, 1808, 1847, 2054, 2377, 2773, 2802, 2936, 3105, 3141, 3170, 3304, 3474], 'taken': [8, 203, 491, 1576, 1851, 2937, 3305], 'up': [9, 204, 492, 1524, 1577, 1852, 2885, 2938, 3253, 3306], 'from': [10, 113, 205, 308, 648, 927, 1390, 1497, 1759, 2008, 2287, 2750, 2858, 3120, 3226, 3489], 'blood': [12, 207, 445, 650, 1391, 1761, 1805, 2010, 2751, 3122, 3491], 'circulation': [13, 208, 651, 1762, 2011, 3123, 3492], 'into': [14, 32, 192, 209, 227, 387, 493, 553, 652, 1396, 1403, 1607, 1678, 1699, 1763, 1853, 1913, 2012, 2756, 2764, 2968, 3039, 3060, 3124, 3132, 3336, 3408, 3429, 3493], 'liver.': [16, 211, 1764, 3125, 3494], 'This': [17, 212], 'work': [18, 213], 'identifies': [19, 214], 'a': [20, 154, 172, 215, 349, 367, 623, 660, 697, 710, 725, 917, 968, 1028, 1038, 1044, 1077, 1093, 1416, 1673, 1983, 2020, 2057, 2070, 2085, 2277, 2328, 2388, 2398, 2404, 2437, 2453, 2777, 3034, 3145, 3403], 'high-affinity': [21, 121, 216, 316, 482, 1464, 1842, 2825, 3193], 'transport': [22, 122, 149, 164, 217, 317, 344, 359, 912, 971, 979, 1250, 1418, 1748, 2272, 2331, 2339, 2610, 2779, 3109, 3147, 3478], 'protein': [23, 218, 570, 913, 1419, 1617, 1930, 2273, 2780, 2978, 3148, 3346], 'mediating': [24, 219, 977, 2337], 'uptake': [26, 59, 77, 97, 221, 254, 272, 292, 647, 800, 1400, 1533, 1540, 1675, 1687, 1698, 1756, 2007, 2160, 2761, 2894, 2901, 3036, 3048, 3059, 3117, 3129, 3262, 3269, 3405, 3417, 3428, 3486], 'bilirubin': [28, 130, 187, 223, 325, 382, 447, 486, 646, 703, 802, 1386, 1402, 1462, 1477, 1503, 1564, 1570, 1598, 1677, 1686, 1697, 1758, 1807, 1846, 2006, 2063, 2162, 2746, 2763, 2823, 2838, 2864, 2925, 2931, 2959, 3038, 3047, 3058, 3119, 3131, 3191, 3206, 3232, 3293, 3299, 3327, 3407, 3416, 3427, 3488], 'and': [29, 65, 72, 89, 104, 128, 138, 188, 224, 260, 267, 284, 299, 323, 333, 383, 433, 489, 551, 741, 793, 816, 955, 991, 1024, 1026, 1087, 1364, 1387, 1451, 1460, 1475, 1484, 1530, 1560, 1584, 1599, 1695, 1793, 1849, 1911, 2101, 2153, 2176, 2315, 2351, 2384, 2386, 2447, 2724, 2747, 2812, 2821, 2836, 2845, 2891, 2921, 2945, 2960, 3056, 3180, 3189, 3204, 3213, 3259, 3289, 3313, 3328, 3425, 3510, 3528, 3550, 3568], 'its': [30, 189, 225, 384, 455, 791, 1388, 1410, 1815, 2151, 2748, 2771, 3139], 'conjugates': [31, 191, 226, 386, 1389, 2749], 'human': [33, 99, 193, 228, 294, 388, 393, 1013, 1032, 1084, 1100, 1204, 1220, 1259, 1362, 1377, 1404, 1566, 1741, 2373, 2392, 2444, 2460, 2564, 2580, 2619, 2722, 2737, 2765, 2927, 3102, 3133, 3295, 3471], 'hepatocytes.': [34, 194, 229, 389, 1679, 1729, 2757, 3040, 3090, 3409, 3459], 'Human': [35, 168, 230, 363], 'embryonic': [36, 231], 'kidney': [37, 232, 1025, 2385], 'cells': [38, 233], '(HEK293)': [39, 234], 'permanently': [40, 235], 'expressing': [41, 236, 1361, 2721], 'recombinant': [43, 238], 'organic': [44, 143, 239, 338, 398, 958, 981, 2318, 2341], 'anion-transporting': [45, 240, 399, 959, 2319], 'polypeptide': [46, 241, 400, 960, 2320], '2': [47, 242, 571, 1618, 1931, 2979, 3347], '(human': [48, 243], 'OATP2,': [49, 124, 152, 244, 319, 347, 1415, 1467, 1488, 2776, 2828, 2849, 3144, 3196, 3217], 'also': [50, 245, 721, 2081], 'known': [51, 246, 1103, 2463], 'as': [52, 247, 724, 957, 1104, 2084, 2317, 2464], 'LST-1': [53, 248], 'or': [54, 249, 1106, 1719, 2466, 3080, 3449], 'OATP-C;': [55, 250], 'symbol': [56, 251, 573, 975, 1109, 1211, 1933, 2335, 2469, 2571], 'SLC21A6)': [57, 252, 1110, 2470], 'showed': [58, 253], '[3H]monoglucuronosyl': [61, 129, 256, 324], 'bilirubin,': [62, 64, 257, 259, 1459, 2820, 3188], '[3H]bisglucuronosyl': [63, 258], '[3H]sulfobromophthalein': [66, 127, 261, 322], 'withKm': [67, 134, 262, 329], 'values': [68, 135, 263, 330], '0.10,': [70, 265], '0.28,': [71, 266], '0.14': [73, 268], 'μm,': [74, 140, 269, 335], 'respectively.': [75, 141, 270, 336], 'High-affinity': [76, 271], 'unconjugated': [79, 186, 274, 381, 699, 2059], '[3H]bilirubin': [80, 275, 1532, 2893, 3261], 'by': [81, 93, 107, 123, 151, 166, 180, 276, 288, 302, 318, 346, 361, 375, 462, 561, 696, 704, 713, 806, 1414, 1429, 1534, 1539, 1582, 1589, 1609, 1705, 1822, 1921, 2056, 2064, 2073, 2166, 2775, 2790, 2895, 2900, 2943, 2950, 2970, 3066, 3143, 3158, 3263, 3268, 3311, 3318, 3338, 3435, 3513], 'OATP2': [82, 103, 169, 277, 298, 364, 1101, 1221, 1363, 1511, 1535, 1583, 1712, 1723, 2461, 2581, 2723, 2872, 2896, 2944, 3073, 3084, 3240, 3264, 3312, 3442, 3453], 'occurred': [83, 278], 'in': [84, 175, 279, 370, 410, 796, 1022, 1031, 1083, 1565, 1586, 1596, 1710, 1724, 1731, 1770, 2156, 2382, 2391, 2443, 2926, 2947, 2957, 3071, 3085, 3092, 3294, 3315, 3325, 3440, 3454, 3461], 'presence': [86, 281], 'albumin': [88, 114, 283, 309, 395, 1498, 1574, 2859, 2935, 3227, 3303], 'was': [90, 285, 706, 803, 1492, 1536, 2066, 2163, 2853, 2897, 3221, 3265], 'not': [91, 162, 286, 357, 1428, 1490, 1683, 1745, 2789, 2851, 3044, 3106, 3157, 3219, 3413, 3475], 'mediated': [92, 150, 165, 287, 345, 360, 712, 1413, 2072, 2774, 3142], 'another': [94, 289], 'basolateral': [95, 290, 1256, 1394, 1423, 1580, 1726, 2616, 2754, 2784, 2941, 3087, 3152, 3309, 3456], 'hepatic': [96, 291, 799, 1309, 1378, 2159, 2669, 2738], 'transporter,': [98, 293], 'OATP8': [100, 105, 125, 295, 300, 320, 1209, 1365, 1432, 1472, 1521, 2569, 2725, 2793, 2833, 2882, 3161, 3201, 3250], '(symbol': [101, 296], 'SLC21A8).': [102, 297], 'differed': [106, 301], 'their': [108, 303], 'capacity': [109, 304], 'to': [110, 119, 305, 314, 450, 459, 484, 622, 657, 659, 708, 967, 1254, 1368, 1421, 1434, 1494, 1501, 1525, 1573, 1620, 1716, 1753, 1810, 1819, 1844, 1982, 2017, 2019, 2068, 2327, 2614, 2728, 2782, 2795, 2855, 2862, 2886, 2934, 2981, 3077, 3114, 3150, 3163, 3223, 3230, 3254, 3302, 3349, 3446, 3483], 'extract': [111, 306, 1495, 2856, 3224], 'substrates': [112, 307, 1465, 1496, 2826, 2857, 3194, 3225], 'before': [115, 310], 'transport.': [116, 311], 'In': [117, 312, 443, 620, 1076, 1803, 1980, 2436], 'comparison': [118, 313], 'transported': [126, 321, 1473, 2834, 3202], 'with': [131, 153, 326, 348, 533, 664, 916, 1043, 1219, 1468, 1478, 1505, 1542, 1549, 1893, 2024, 2276, 2403, 2579, 2829, 2839, 2866, 2903, 2910, 3197, 3207, 3234, 3271, 3278], 'lower': [132, 327, 1480, 2841, 3209], 'affinity,': [133, 328], '3.3': [137, 332], '0.5': [139, 334], 'The': [142, 337, 430, 738, 1355, 1691, 1790, 2098, 2715, 3052, 3421], 'anion': [144, 339], 'indocyanine': [145, 340, 396, 817, 2177], 'green': [146, 341, 397, 818, 2178], 'potently': [147, 342], 'inhibited': [148, 343, 1510, 2871, 3239], 'Ki': [155, 350], 'value': [156, 351, 1046, 2406], '112': [158, 353], 'nm,': [159, 354], 'but': [160, 355, 1427, 1489, 1515, 2788, 2850, 2876, 3156, 3218, 3244], 'did': [161, 356], 'inhibit': [163, 358], 'OATP8.': [167, 362], 'may': [170, 365, 1750, 3111, 3480], 'play': [171, 366], 'key': [173, 368], 'role': [174, 369], 'prevention': [177, 372], 'hyperbilirubinemia': [179, 374], 'facilitating': [181, 376], 'selective': [183, 378, 1755, 3116, 3485], 'entry': [184, 379], 'glucuronate': [190, 385, 534, 1894], 'sulfobromophthalein': [390, 814, 2174], '17%-glucuronosyl': [391], 'estradiol': [392], 'serum': [394, 451, 1811], 'high': [401, 1020, 1506, 2380, 2867, 3235], 'pressure': [402], 'liquid': [403], 'chromatography': [404], 'main': [407, 1767], 'bile': [408, 554, 984, 1608, 1768, 1914, 2344, 2969, 3337], 'pigment': [409, 1769], 'most': [411, 1771], 'mammals,': [412, 1772], 'catabolism': [419, 1779], '(1Chowdhury': [420, 728, 1780, 2088], 'J.R.': [421, 729, 1781, 2089], 'Chowdhury': [422, 730, 1782, 2090], 'N.R.': [423, 731, 1783, 2091], 'Wolkoff': [424, 671, 732, 841, 936, 1060, 1784, 2031, 2092, 2201, 2296, 2420], 'A.W.': [425, 672, 733, 842, 937, 1061, 1785, 2032, 2093, 2202, 2297, 2421], 'Arias': [426, 734, 1786, 2094], 'I.M.': [427, 429, 514, 735, 737, 1787, 1789, 1874, 2095, 2097], 'Anas': [428, 736, 1788, 2096], 'Liver:': [431, 739, 1791, 2099], 'Biology': [432, 740, 1792, 2100], 'Pathobiology.': [434, 742, 1794, 2102], '3rd': [435, 743, 1795, 2103], 'Ed.': [436, 744, 1796, 2104], 'Raven': [437, 745, 1797, 2105], 'Press,': [438, 746, 1798, 2106], 'New': [439, 747, 1799, 2107], 'York1994:': [440, 748, 1800, 2108], '471-504Google': [441, 749, 1801, 2109], 'Scholar).': [442, 480, 619, 788, 910, 1011, 1075, 1197, 1245, 1301, 1354, 1802, 1840, 1979, 2148, 2270, 2371, 2435, 2557, 2605, 2661, 2714, 3398], 'circulation,': [446, 1806], 'bound': [449, 1572, 1809, 2933, 3301], 'albumin,': [452, 485, 1812, 1845], 'which': [453, 693, 1016, 1213, 1502, 1813, 2053, 2376, 2573, 2863, 3231], 'prevents': [454, 1814], 'potential': [456, 1816], 'toxicity': [457, 1817], 'thought': [458, 1818], 'be': [460, 709, 1703, 1820, 2069, 3064, 3433], 'caused': [461, 1821], 'free': [464, 1824], 'ligand': [465, 1825], '(2Brodersen': [466, 1826], 'R.': [467, 1165, 1827, 2525], 'Stern': [468, 1828], 'L.': [469, 516, 770, 885, 1829, 1876, 2130, 2245], 'Acta': [470, 1830], 'Paediatr.': [471, 1831], 'Scand.': [472, 1832], '1990;': [473, 1833], '79:': [474, 1834], '12-19Crossref': [475, 1835], 'PubMed': [476, 508, 525, 546, 593, 615, 640, 688, 763, 784, 832, 858, 879, 906, 950, 1007, 1071, 1125, 1153, 1193, 1241, 1275, 1297, 1328, 1350, 1644, 1665, 1836, 1868, 1885, 1906, 1953, 1975, 2000, 2048, 2123, 2144, 2192, 2218, 2239, 2266, 2310, 2367, 2431, 2485, 2513, 2553, 2601, 2635, 2657, 2688, 2710, 3005, 3026, 3373, 3394], 'Scopus': [477, 509, 526, 547, 594, 616, 641, 689, 764, 785, 833, 859, 880, 907, 951, 1008, 1072, 1154, 1194, 1242, 1298, 1351, 1645, 1666, 1837, 1869, 1886, 1907, 1954, 1976, 2001, 2049, 2124, 2145, 2193, 2219, 2240, 2267, 2311, 2368, 2432, 2514, 2554, 2602, 2658, 2711, 3006, 3027, 3374, 3395], '(64)': [478, 1838], 'Google': [479, 511, 528, 549, 596, 618, 643, 691, 766, 787, 835, 861, 882, 909, 953, 1010, 1074, 1126, 1156, 1196, 1244, 1276, 1300, 1329, 1353, 1647, 1668, 1839, 1871, 1888, 1909, 1956, 1978, 2003, 2051, 2126, 2147, 2195, 2221, 2242, 2269, 2313, 2370, 2434, 2486, 2516, 2556, 2604, 2636, 2660, 2689, 2713, 3008, 3029, 3376, 3397], 'Despite': [481, 1841], 'binding': [483, 1843], 'rapidly': [488, 1848], 'selectively': [490, 1850], 'liver': [495, 653, 929, 1205, 1567, 1701, 1855, 2013, 2289, 2565, 2928, 3062, 3296, 3431], '(3Scharschmidt': [496, 820, 1856, 2180], 'B.F.': [497, 674, 752, 821, 844, 1857, 2034, 2112, 2181, 2204], 'Waggoner': [498, 677, 753, 822, 847, 1858, 2037, 2113, 2182, 2207], 'J.G.': [499, 678, 754, 823, 848, 1859, 2038, 2114, 2183, 2208], 'Berk': [500, 679, 755, 824, 849, 1860, 2039, 2115, 2184, 2209], 'P.D.': [501, 680, 756, 825, 850, 1861, 2040, 2116, 2185, 2210], 'J.': [502, 520, 542, 582, 586, 605, 611, 635, 676, 757, 826, 846, 902, 1112, 1120, 1142, 1182, 1223, 1230, 1262, 1270, 1279, 1286, 1315, 1323, 1332, 1339, 1633, 1637, 1655, 1661, 1862, 1880, 1902, 1942, 1946, 1965, 1971, 1995, 2036, 2117, 2186, 2206, 2262, 2472, 2480, 2502, 2542, 2583, 2590, 2622, 2630, 2639, 2646, 2675, 2683, 2692, 2699, 2994, 2998, 3016, 3022, 3362, 3366, 3384, 3390, 3517], 'Clin.': [503, 758, 827, 1863, 2118, 2187], 'Invest.': [504, 759, 828, 1864, 2119, 2188], '1975;': [505, 760, 829, 1865, 2120, 2189], '56:': [506, 761, 830, 1866, 2121, 2190], '1280-1292Crossref': [507, 762, 831, 1867, 2122, 2191], '(202)': [510, 765, 834, 1870, 2125, 2194], 'Scholar,': [512, 597, 750, 836, 862, 883, 1127, 1157, 1277, 1330, 1872, 1957, 2110, 2196, 2222, 2243, 2487, 2517, 2637, 2690], '4Arias': [513, 1873], 'Johnson': [515, 1875], 'Wolfson': [517, 1877], 'S.': [518, 888, 945, 1179, 1878, 2248, 2305, 2539], 'Am.': [519, 1119, 1269, 1322, 1879, 2479, 2629, 2682], 'Physiol.': [521, 1121, 1271, 1324, 1881, 2481, 2631, 2684], '1961;': [522, 1882], '200:': [523, 1883], '1091-1094Crossref': [524, 1884], '(82)': [527, 1887], 'Scholar),': [529, 550, 644, 692, 1889, 1910, 2004, 2052], 'biotransformed': [530, 1890], 'upon': [531, 1891], 'conjugation': [532, 1892], '(5Senafi': [535, 1895], 'S.B.': [536, 1896], 'Clarke': [537, 1897], 'D.J.': [538, 1898], 'Burchell': [539, 606, 1656, 1899, 1966, 3017, 3385], 'B.': [540, 607, 933, 935, 1000, 1002, 1053, 1055, 1129, 1657, 1900, 1967, 2293, 2295, 2360, 2362, 2413, 2415, 2489, 3018, 3386], 'Biochem.': [541, 610, 901, 1660, 1901, 1970, 2261, 3021, 3389], '1994;': [543, 947, 1903, 2307], '303:': [544, 1904], '233-240Crossref': [545, 1905], '(228)': [548, 1908], 'secreted': [552, 1912], 'across': [555, 1392, 1578, 1915, 2752, 2939, 3307], 'canalicular': [557, 1623, 1917, 2984, 3352], 'membrane': [558, 715, 1257, 1395, 1424, 1437, 1581, 1625, 1727, 1918, 2075, 2617, 2755, 2785, 2798, 2942, 2986, 3088, 3153, 3166, 3310, 3354, 3457], 'hepatocytes': [560, 705, 1260, 1920, 2065, 2620], 'an': [562, 1202, 1306, 1922, 2562, 2666], 'ATP-dependent': [563, 1923], 'conjugate': [564, 1612, 1924, 2973, 3341], 'export': [565, 1613, 1925, 2974, 3342], 'pump': [566, 1614, 1926, 2975, 3343], 'termed': [567, 1208, 1927, 2568], 'multidrug': [568, 1615, 1928, 2976, 3344], 'resistance': [569, 1616, 1929, 2977, 3345], '(transporter': [572, 1932], 'ABCC2)': [574, 1934], '(6Kamisako': [575, 1626, 1935, 2987, 3355], 'T.': [576, 1159, 1163, 1167, 1177, 1627, 1936, 2519, 2523, 2527, 2537, 2988, 3356], 'Leier': [577, 600, 1628, 1650, 1937, 1960, 2989, 3011, 3357, 3379], 'I.': [578, 601, 1629, 1651, 1938, 1961, 2990, 3012, 3358, 3380], 'Cui': [579, 1113, 1224, 1263, 1280, 1316, 1333, 1630, 1939, 2473, 2584, 2623, 2640, 2676, 2693, 2991, 3359], 'Y.': [580, 1114, 1131, 1135, 1225, 1264, 1281, 1317, 1334, 1631, 1940, 2474, 2491, 2495, 2585, 2624, 2641, 2677, 2694, 2992, 3360], 'König': [581, 1632, 1941, 2993, 3361], 'Buchholz': [583, 602, 1634, 1652, 1943, 1962, 2995, 3013, 3363, 3381], 'U.': [584, 603, 944, 996, 1635, 1653, 1944, 1963, 2304, 2356, 2996, 3014, 3364, 3382], 'Hummel-Eisenbeiss': [585, 604, 1636, 1654, 1945, 1964, 2997, 3015, 3365, 3383], 'Keppler': [587, 608, 1117, 1228, 1267, 1284, 1320, 1337, 1638, 1658, 1947, 1968, 2477, 2588, 2627, 2644, 2680, 2697, 2999, 3019, 3367, 3387], 'D.': [588, 609, 1118, 1169, 1229, 1268, 1285, 1321, 1338, 1639, 1659, 1948, 1969, 2478, 2529, 2589, 2628, 2645, 2681, 2698, 3000, 3020, 3368, 3388, 3498], 'Hepatology.': [589, 1003, 1640, 1949, 2363, 3001, 3369], '1999;': [590, 781, 1145, 1185, 1641, 1950, 2141, 2505, 2545, 3002, 3370], '30:': [591, 1642, 1951, 3003, 3371], '485-490Crossref': [592, 1643, 1952, 3004, 3372], '(165)': [595, 1646, 1955, 3007, 3375], '7Jedlitschky': [598, 1958], 'G.': [599, 1649, 1959, 3010, 3378, 3569], '1997;': [612, 1004, 1662, 1972, 2364, 3023, 3391], '327:': [613, 1663, 1973, 3024, 3392], '305-310Crossref': [614, 1664, 1974, 3025, 3393], '(257)': [617, 1667, 1977, 3028, 3396], 'addition': [621, 1981], 'reduction': [624, 1984], 'UDP-glucuronosyl': [626, 1591, 1986, 2952, 3320], 'transferase': [627, 1592, 1987, 2953, 3321], 'activity': [628, 1988], '(8Black': [629, 1989], 'M.': [630, 1161, 1173, 1175, 1990, 2521, 2533, 2535, 3518, 3551], 'Billing': [631, 1991], 'B.H.': [632, 1992], 'N.': [633, 1993], 'Engl.': [634, 1994], 'Med.': [636, 1996], '1969;': [637, 1997], '280:': [638, 1998], '1266-1271Crossref': [639, 1999], '(233)': [642, 2002], 'impaired': [645, 2005], 'has': [654, 720, 924, 2014, 2080, 2284], 'been': [655, 722, 925, 2015, 2082, 2285], 'suggested': [656, 2016], 'contribute': [658, 1752, 2018, 3113, 3482], 'subgroup': [661, 2021], 'patients': [663, 2023], "Gilbert's": [665, 2025], 'syndrome': [666, 2026], '(9Martin': [667, 2027], 'J.F.': [668, 838, 2028, 2198], 'Vierling': [669, 839, 2029, 2199], 'J.M.': [670, 840, 2030, 2200], 'Scharschmidt': [673, 843, 2033, 2203], 'Vergalla': [675, 845, 2035, 2205], 'Gastroenterology.': [681, 851, 1064, 2041, 2211, 2424], '1976;': [682, 852, 876, 2042, 2212, 2236], '70:': [683, 853, 2043, 2213], '385-391Abstract': [684, 854, 2044, 2214], 'Full': [685, 855, 1068, 1148, 1150, 1188, 1190, 1236, 1238, 1292, 1294, 1345, 1347, 2045, 2215, 2428, 2508, 2510, 2548, 2550, 2596, 2598, 2652, 2654, 2705, 2707], 'Text': [686, 856, 1069, 1149, 1151, 1189, 1191, 1237, 1239, 1293, 1295, 1346, 1348, 2046, 2216, 2429, 2509, 2511, 2549, 2551, 2597, 2599, 2653, 2655, 2706, 2708], 'PDF': [687, 857, 1070, 1152, 1192, 1240, 1296, 1349, 2047, 2217, 2430, 2512, 2552, 2600, 2656, 2709], '(81)': [690, 860, 2050, 2220], 'characterized': [695, 2055], 'mild': [698, 2058], 'hyperbilirubinemia.': [700, 2060], 'Uptake': [701, 2061], 'considered': [707, 2067], 'process': [711, 2071], 'specific': [714, 2074], 'proteins,': [716, 2076], 'although': [717, 2077], 'passive': [718, 1689, 2078, 3050, 3419], 'diffusion': [719, 2079], 'proposed': [723, 2083], 'possible': [726, 2086], 'mechanism': [727, 2087], '3Scharschmidt': [751, 2111], 'Scholar,10Mediavilla': [767, 2127], 'M.G.': [768, 2128], 'Pascolo': [769, 2129], 'Rodriguez': [771, 2131], 'J.V.': [772, 2132], 'Guibert': [773, 2133], 'E.E.': [774, 2134], 'Ostrow': [775, 897, 2135, 2257], 'J.D.': [776, 898, 2136, 2258], 'Tiribelli': [777, 899, 2137, 2259], 'C.': [778, 900, 2138, 2260], 'FEBS': [779, 2139], 'Lett.': [780, 2140], '463:': [782, 2142], '143-145Crossref': [783, 2143], '(21)': [786, 2146], 'Because': [789, 2149], 'instability': [792, 2152], 'low': [794, 1029, 2154, 2389], 'solubility': [795, 2155], 'aqueous': [797, 2157], 'solution,': [798, 2158], 'studied': [804, 2164], 'predominantly': [805, 2165], 'use': [807, 2167], 'structurally': [809, 1450, 2169, 2811, 3179], 'related': [810, 1453, 2170, 2814, 3182], 'anionic': [811, 1455, 2171, 2816, 3184], 'substances': [812, 2172], 'like': [813, 2173], '(BSP)1': [815, 2175], '(ICG)': [819, 2179], '9Martin': [837, 2197], '11Okuda': [863, 2223], 'K.': [864, 870, 874, 2224, 2230, 2234, 3548], 'Ohkubo': [865, 2225], 'H.': [866, 868, 872, 1171, 1181, 2226, 2228, 2232, 2531, 2541], 'Musha': [867, 2227], 'Kotoda': [869, 2229], 'Abe': [871, 2231], 'Tanikawa': [873, 2233], 'Gut.': [875, 2235], '17:': [877, 2237], '588-594Crossref': [878, 2238], '(24)': [881, 908, 2241, 2268], '12Pascolo': [884, 2244], 'Del': [886, 2246], 'Vecchio': [887, 2247], 'Koehler': [889, 2249], 'R.K.': [890, 2250], 'Bayon': [891, 2251], 'J.E.': [892, 2252], 'Webster': [893, 2253], 'C.C.': [894, 2254], 'Mukerjee': [895, 2255], 'P.': [896, 2256], '1996;': [903, 2263], '316:': [904, 2264], '999-1004Crossref': [905, 2265], 'A': [911, 2271], 'for': [914, 1041, 1079, 1466, 1557, 2274, 2401, 2439, 2827, 2918, 3195, 3286, 3505, 3541, 3561, 3579], 'BSP': [915, 992, 1042, 1474, 2275, 2352, 2402, 2835, 3203, 3512], 'Michaelis-Menten': [918, 2278], 'constant': [919, 2279], '(Km)': [920, 2280], '1.5': [922, 2282], 'μm': [923, 1049, 1527, 2283, 2409, 2888, 3256], 'cloned': [926, 1092, 1201, 2286, 2452, 2561], 'rat': [928, 2288], '(13Jacquemin': [930, 2290], 'E.': [931, 2291], 'Hagenbuch': [932, 999, 1052, 2292, 2359, 2412], 'Stieger': [934, 1001, 1054, 2294, 2361, 2414], 'Meier': [938, 1062, 2298, 2422], 'P.J.': [939, 994, 1063, 2299, 2354, 2423], 'Proc.': [940, 2300], 'Natl.': [941, 2301], 'Acad.': [942, 2302], 'Sci.': [943, 2303], 'A.': [946, 998, 2306, 2358, 3529], '91:': [948, 2308], '133-137Crossref': [949, 2309], '(544)': [952, 2312], 'Scholar)': [954, 2314], 'designated': [956, 2316], '1': [961, 1483, 2321, 2844, 3212], '(rat': [962, 2322], 'OATP1).': [963, 2323], 'Rat': [964, 2324], 'OATP1': [965, 1014, 2325, 2374], 'belongs': [966, 2326], 'family': [969, 1380, 1743, 2329, 2740, 3104, 3473], 'proteins': [972, 1251, 1749, 2332, 2611, 3110, 3479], '(OATP': [973, 2333], 'family,': [974, 1099, 2334, 2459], 'SLC21A)': [976, 2336], 'anions': [982, 2342], 'including': [983, 2343], 'salts,': [985, 2345], 'steroid': [986, 2346], 'conjugates,': [987, 2347], 'thyroid': [988, 2348], 'hormones,': [989, 2349], 'prostaglandins,': [990, 2350], '(14Meier': [993, 2353], 'Eckhardt': [995, 2355], 'Schroeder': [997, 2357], '26:': [1005, 2365], '1667-1677Crossref': [1006, 2366], '(322)': [1009, 2369], 'For': [1012, 2372], '(SLC21A3),': [1015, 2375], 'expressed': [1018, 2378], 'at': [1019, 1027, 1512, 1522, 2379, 2387, 2873, 2883, 3241, 3251], 'levels': [1021, 2381], 'brain': [1023, 2383], 'level': [1030, 2390], 'liver,': [1033, 1085, 2393, 2445], 'kinetic': [1034, 2394], 'studies': [1035, 1541, 2395, 2902, 3270], 'revealed': [1036, 2396], 'only': [1037, 2397], 'moderate': [1039, 2399], 'affinity': [1040, 1481, 2400, 2842, 3210], 'Km': [1045, 2405], '20': [1048, 2408], '(15Kullak-Ublick': [1050, 2410], 'G.A.': [1051, 2411], 'Schteingart': [1056, 2416], 'C.D.': [1057, 2417], 'Hofmann': [1058, 2418], 'A.F.': [1059, 2419], '1995;': [1065, 2425], '109:': [1066, 2426], '1274-1282Abstract': [1067, 2427], '(368)': [1073, 2433], 'search': [1078, 2438], 'additional': [1080, 1203, 1685, 1747, 2440, 2563, 3046, 3108, 3415, 3477], 'OATP': [1081, 1206, 1379, 1742, 2441, 2566, 2739, 3103, 3472], 'isoforms': [1082, 2442], 'we': [1086, 1200, 1552, 1681, 2446, 2560, 2913, 3042, 3281, 3411], 'other': [1088, 2448], 'groups': [1089, 2449], 'have': [1090, 2450], 'recently': [1091, 2451], 'new': [1094, 2454], 'member': [1095, 2455], 'this': [1097, 2457], 'transporter': [1098, 2458], '(also': [1102, 2462], 'LST1': [1105, 2465], 'OATP-C,': [1107, 2467], 'gene': [1108, 1714, 2468, 3075, 3444], '(16König': [1111, 1261, 1314, 2471, 2621, 2674], 'Nies': [1115, 1226, 1265, 1282, 1318, 1335, 2475, 2586, 2625, 2642, 2678, 2695], 'A.T.': [1116, 1227, 1266, 1283, 1319, 1336, 2476, 2587, 2626, 2643, 2679, 2696], '2000;': [1122, 1233, 1272, 1289, 1325, 1342, 2482, 2593, 2632, 2649, 2685, 2702], '278:': [1123, 1273, 1326, 2483, 2633, 2686], 'G156-G164Crossref': [1124, 1274, 1327, 2484, 2634, 2687], '17Hsiang': [1128, 2488], 'Zhu': [1130, 2490], 'Wang': [1132, 2492], 'Z.': [1133, 2493], 'Wu': [1134, 2494], 'Sasseville': [1136, 2496], 'V.': [1137, 2497], 'Yang': [1138, 2498], 'W.P.': [1139, 2499], 'Kirchgessner': [1140, 2500], 'T.G.': [1141, 2501], 'Biol.': [1143, 1183, 1231, 1287, 1340, 2503, 2543, 2591, 2647, 2700], 'Chem.': [1144, 1184, 1232, 1288, 1341, 2504, 2544, 2592, 2648, 2701], '274:': [1146, 1186, 2506, 2546], '37161-37168Abstract': [1147, 2507], '(582)': [1155, 2515], '18Abe': [1158, 2518], 'Kakyo': [1160, 2520], 'Tokui': [1162, 2522], 'Nakagomi': [1164, 2524], 'Nishio': [1166, 2526], 'Nakai': [1168, 2528], 'Nomura': [1170, 2530], 'Unno': [1172, 2532], 'Suzuki': [1174, 2534], 'Naitoh': [1176, 2536], 'Matsuno': [1178, 2538], 'Yawo': [1180, 2540], '17159-17163Abstract': [1187, 2547], '(487)': [1195, 2555], 'Most': [1198, 2558], 'recently,': [1199, 2559], 'isoform': [1207, 1431, 2567, 2792, 3160], '(gene': [1210, 2570], 'SLC21A8),': [1212, 2572], 'shares': [1214, 2574], '80%': [1215, 2575], 'identical': [1216, 2576], 'amino': [1217, 2577], 'acids': [1218, 2578], '(19König': [1222, 2582], '275:': [1234, 1290, 1343, 2594, 2650, 2703], '23161-23168Abstract': [1235, 1291, 1344, 2595, 2651, 2704], '(445)': [1243, 1299, 1352, 2603, 2659, 2712], 'Antibodies': [1246, 2606], 'raised': [1247, 2607], 'against': [1248, 2608], 'both': [1249, 1312, 2609, 2672], 'localized': [1252, 1420, 1433, 1619, 2612, 2781, 2794, 2980, 3149, 3162, 3348], 'them': [1253, 2613], '19König': [1278, 1331, 2638, 2691], 'Northern': [1302, 2662], 'blot': [1303, 2663], 'analyses': [1304, 2664], 'demonstrated': [1305, 1538, 2665, 2899, 3267], 'apparently': [1307, 2667], 'exclusive': [1308, 2668], 'expression': [1310, 2670], 'transporters': [1313, 2673], 'availability': [1356, 2716], 'cell': [1358, 2718], 'lines': [1359, 2719], 'stably': [1360, 2720], 'enabled': [1366, 2726], 'us': [1367, 2727], 'answer': [1369, 2729], 'question': [1371, 2731], 'whether': [1373, 2733], 'these': [1374, 2734], 'two': [1375, 2735], 'major': [1376, 1417, 2736, 2778, 3146], 'members': [1381, 2741], 'are': [1382, 1604, 2742, 2965, 3333], 'capable': [1383, 2743], 'transporting': [1385, 2745], 'hepatocytes.DISCUSSIONWe': [1397], 'conclude': [1398, 2759, 3127], 'that': [1399, 1736, 2760, 3097, 3128, 3466], 'hepatocytes,': [1405, 1426, 2766, 2787, 3134, 3155], 'first': [1407, 2768, 3136], 'step': [1408, 2769, 3137], 'detoxification,': [1411, 2772, 3140], 'same': [1436, 2797, 3165], 'domain.': [1438, 2799, 3167], 'Our': [1439, 2800, 3168, 3399], 'conclusion': [1440, 2801, 3169], 'based': [1442, 2803, 3171], 'on': [1443, 1520, 2804, 2881, 3172, 3249, 3543], 'following': [1445, 1555, 2806, 2916, 3174, 3284], 'experimental': [1446, 2807, 3175], 'data:': [1447, 2808, 3176], '(a)': [1448, 2809, 3177], 'chemically': [1452, 2813, 3181], 'lipophilic': [1454, 2815, 3183], 'compounds': [1456, 2817, 3185], 'BSP,': [1457, 2818, 3186], 'monoglucuronosyl': [1458, 1476, 1597, 2819, 2837, 2958, 3187, 3205, 3326], 'bisglucuronosyl': [1461, 1600, 2822, 2961, 3190, 3329], 'were': [1463, 2824, 3192], 'nanomolarKm': [1469, 2830, 3198], 'values,': [1470, 2831, 3199], 'whereas': [1471, 2832, 3200], 'markedly': [1479, 2840, 3208], '(Fig.': [1482, 1499, 1528, 1546, 1568, 2843, 2860, 2889, 2907, 2929, 3211, 3228, 3257, 3275, 3297], 'Table': [1485, 2846, 3214], 'I);': [1486, 2847, 3215], '(b)': [1487, 2848, 3216], 'OATP8,': [1491, 2852, 3220], 'able': [1493, 2854, 3222], '2)': [1500, 2861, 3229], 'binds': [1504, 2865, 3233], 'affinity;': [1507, 2868, 3236], '(c)': [1508, 2869, 3237], 'ICG': [1509, 2870, 3238], 'nanomolar': [1513, 2874, 3242], 'concentrations': [1514, 1523, 2875, 2884, 3243, 3252], 'exerted': [1516, 2877, 3245], 'no': [1517, 2878, 3246], 'inhibitory': [1518, 2879, 3247], 'effect': [1519, 2880, 3248], '10': [1526, 2887, 3255], '3);': [1529, 2890, 3258], '(d)': [1531, 2892, 3260], 'directly': [1537, 2898, 3266], 'OATP2-expressing': [1543, 2904, 3272], 'HEK': [1544, 2905, 3273], 'transfectants': [1545, 2906, 3274], '4).': [1547, 2908, 3276], 'Together': [1548, 2909, 3277], 'previous': [1550, 2911, 3279], 'data,': [1551, 2912, 3280], 'propose': [1553, 2914, 3282], 'scheme': [1556, 2917, 3285], 'detoxification': [1559, 2920, 3288], 'elimination': [1561, 2922, 3290], 'pathway': [1562, 2923, 3291], '5):': [1569, 2930, 3298], '(B)': [1571, 2932, 3300], 'conjugated': [1585, 2946, 3314], 'hepatocyte': [1588, 1622, 2949, 2983, 3317, 3351], '1A': [1593, 2954, 3322], '(UGT1A1),': [1594, 2955, 3323], 'resulting': [1595, 2956, 3324], 'bilirubin.': [1601, 2962, 3330], 'Bilirubin': [1602, 2963, 3331], 'glucuronides': [1603, 2964, 3332], 'finally': [1605, 2966, 3334], 'excreted': [1606, 2967, 3335], 'apical': [1611, 2972, 3340], '(apical)': [1624, 2985, 3353], 'Scholar,7Jedlitschky': [1648, 3009, 3377], 'Scholar).Our': [1669, 3030], 'results': [1670, 3031, 3400], 'here': [1671, 3032, 3401], 'establish': [1672, 3033, 3402], 'carrier-mediated': [1674, 1694, 3035, 3055, 3404, 3424], 'However,': [1680, 3041, 3410], 'do': [1682, 3043, 3412], 'exclude': [1684, 3045, 3414], 'through': [1688, 3049, 3418], 'diffusion.': [1690, 3051, 3420], 'differentiation': [1692, 3053, 3422], 'between': [1693, 3054, 3423], 'diffusional': [1696, 3057, 3426], 'will': [1702, 3063, 3432], 'supported': [1704, 3065, 3434], 'identification': [1707, 3068, 3437], 'mutations': [1709, 3070, 3439], '(SLC21A6)': [1713, 3074, 3443], 'leading': [1715, 3076, 3445], 'loss': [1718, 3079, 3448], 'functional': [1720, 3081, 3450], 'impairment': [1721, 3082, 3451], 'Moreover,': [1730, 3091, 3460], 'view': [1732, 3093, 3462], 'fact': [1735, 3096, 3465], 'current': [1737, 3098, 3467], 'knowledge': [1738, 3099, 3468], 'complete,': [1746, 3107, 3476], 'further': [1751, 3112, 3481], 'DISCUSSIONWe': [2758], 'We': [3126, 3495], 'thank': [3496], 'W.': [3497], 'Lehmann': [3499], '(Deutsches': [3500, 3553, 3571], 'Krebsforschungszentrum,': [3501, 3554, 3572], 'Spectroscopy,': [3502], 'Heidelberg,': [3503, 3559, 3577], 'Germany)': [3504, 3560, 3578], 'analysis': [3506], 'labeled': [3509], 'unlabeled': [3511], 'nanoelectrospray': [3514], 'mass': [3515], 'spectrometry,': [3516], 'Crawford': [3519], '(University': [3520, 3532], 'Florida,': [3522], 'Department': [3523], 'Pathology,': [3525], 'Gainesville,': [3526], 'FL)': [3527], 'F.': [3530], 'McDonagh': [3531], 'California,': [3534], 'Division': [3535, 3555, 3573], 'Gastroenterology,': [3537], 'San': [3538], 'Francisco,': [3539], 'CA)': [3540], 'advice': [3542], 'preparation': [3545], '[3H]bilirubin,': [3547, 3567], 'Bode': [3549], 'Donner': [3552], 'Tumor': [3557, 3575], 'Biochemistry,': [3558, 3576], 'help': [3562], 'during': [3563], 'biosynthesis': [3565], 'Jedlitschky': [3570], 'critical': [3580], 'reading': [3581], 'manuscript.': [3584]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019532583', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2025-01-02T19:52:07.433569', 'created_date': '2016-06-24'}