Publication Information

{'id': 'https://openalex.org/W4200460130', 'doi': 'https://doi.org/10.1021/acsomega.1c06163', 'title': 'Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein', 'display_name': 'Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 Are Involved in the Hepatic Uptake of Phenolsulfonphthalein', 'publication_year': 2021, 'publication_date': '2021-12-16', 'ids': {'openalex': 'https://openalex.org/W4200460130', 'doi': 'https://doi.org/10.1021/acsomega.1c06163', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34984313'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acsomega.1c06163', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210239500', 'display_name': 'ACS Omega', 'issn_l': '2470-1343', 'issn': ['2470-1343'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American 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'excreted': [30], 'urine': [32], 'bile.': [34], 'The': [35, 158], 'urinary': [36], 'excretion': [37, 285], 'of': [38, 98, 133, 190, 224, 245, 257, 268, 286], 'mediated': [41], 'by': [42], 'organic': [43, 101, 113], 'anion': [44, 102], 'transporter': [45, 115], '1/3': [46], '(OAT1/3)': [47], 'multidrug': [49], 'resistance': [50], 'protein': [51], '2': [52], '(MRP2).': [53], 'In': [54, 83, 203], 'biliary': [55, 284], 'excretion,': [56], 'effluxed': [59], 'from': [60, 76, 247, 259, 270], 'hepatocytes': [61, 80, 260], 'bile': [64, 275], 'via': [65], 'MRP2.': [66], 'However,': [67, 187], 'so': [68], 'far,': [69], 'molecular': [71], 'mechanism': [72], 'for': [73, 146, 161], 'transport': [75, 156, 267], 'blood': [78, 249, 272], 'unclear.': [82], 'present': [85, 229], 'study,': [86], 'six': [87], 'human': [88], 'major': [89], 'hepatic': [90, 131], 'uptake': [91, 132, 167, 244], 'transporters': [92], 'expressed': [93], 'on': [94, 200], 'basolateral': [96], 'membrane': [97], 'hepatocytes,': [99, 251], 'namely,': [100], 'transporting': [103], 'polypeptide': [104, 111], '1B1': [105], '(OATP1B1),': [106], 'OATP1B3,': [107, 148, 237], 'OATP2B1,': [108, 150], 'Na+/taurocholate': [109], 'cotransporting': [110], '(NTCP),': [112], 'cation': [114], '1': [116], '(OCT1),': [117], 'OAT2,': [119], 'have': [120], 'investigated': [122], 'to': [123, 216, 273], 'see': [124], 'whether': [125], 'they': [126], 'are': [127, 240], 'involved': [128, 241], 'PSP.': [134, 225, 287], 'An': [135], 'vitro': [137], 'cell-based': [138], 'study': [139, 206, 230], 'demonstrated': [140], 'that': [141, 213, 232], 'substrate': [145], 'OATP1B1,': [147, 236], 'with': [151, 183, 254], 'OATP1B3': [152], 'showing': [153], 'highest': [155], 'efficiency.': [157], 'Km': [159], 'values': [160], 'OATP1B1-,': [162], 'OATP1B3-,': [163], 'OATP2B1-mediated': [165], 'were': [168], '11.3': [169], '±': [170, 173, 177], '1.5,': [171, 174], '7.0': [172], '5.1': [176], '1.0': [178], 'μM,': [179], 'respectively.': [180], 'interacts': [182], 'known': [184], 'OATP': [185], 'substrates/inhibitors.': [186], 'presence': [189], 'medium': [195], 'no': [197], 'significant': [198], 'effect': [199], "OATP's": [201], 'function.': [202], 'vivo': [204], 'pharmacokinetic': [205], 'wild-type': [208], 'Oatp1b2-knockout': [210, 214], 'mice': [211], 'showed': [212, 231], 'led': [215], 'elevated': [217], 'plasma': [218], 'concentration': [219], 'decreased': [221], 'liver': [222], 'accumulation': [223], 'Taken': [226], 'together,': [227], 'liver,': [235], 'OATP2B1': [239], 'which,': [252], 'along': [253], 'MRP2-mediated': [255], 'efflux': [256], 'bile,': [263], 'constitute': [264], 'vectorial': [266], 'may': [277], 'play': [278], 'critical': [280], 'role': [281]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4200460130', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-24T05:19:49.834253', 'created_date': '2021-12-31'}