Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2018474075', 'doi': 'https://doi.org/10.1074/jbc.m111.230870', 'title': 'Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death', 'display_name': 'Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death', 'publication_year': 2011, 'publication_date': '2011-03-10', 'ids': {'openalex': 'https://openalex.org/W2018474075', 'doi': 'https://doi.org/10.1074/jbc.m111.230870', 'mag': '2018474075', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21388949', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3091202'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.230870', 'pdf_url': 'http://www.jbc.org/article/S0021925820514117/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820514117/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007740890', 'display_name': 'Thomas D. Mullen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Thomas D. Mullen', 'raw_affiliation_strings': ['Departments of Medicine and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicine and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033056679', 'display_name': 'Russell W. Jenkins', 'orcid': 'https://orcid.org/0000-0001-6110-2148'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Russell W. Jenkins', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020029085', 'display_name': 'Christopher J. Clarke', 'orcid': 'https://orcid.org/0000-0002-4855-522X'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Clarke', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103946886', 'display_name': 'Jacek Bielawski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacek Bielawski', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090422329', 'display_name': 'Yusuf A. Hannun', 'orcid': 'https://orcid.org/0000-0003-3349-3369'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yusuf A. Hannun', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023831938', 'display_name': 'Lina M. Obeid', 'orcid': 'https://orcid.org/0000-0002-0734-0847'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}, {'id': 'https://openalex.org/I4210132004', 'display_name': 'Ralph H. Johnson VA Medical Center', 'ror': 'https://ror.org/030ma0n95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210131075', 'https://openalex.org/I4210132004']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Lina M. Obeid', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'Departments of Medicine and', 'From the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401 and'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425', 'institution_ids': ['https://openalex.org/I153297377']}, {'raw_affiliation_string': 'From the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401 and', 'institution_ids': ['https://openalex.org/I4210132004']}, {'raw_affiliation_string': 'Departments of Medicine and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5023831938'], 'corresponding_institution_ids': ['https://openalex.org/I153297377', 'https://openalex.org/I4210132004'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.795, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 89, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '286', 'issue': '18', 'first_page': '15929', 'last_page': '15942'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9621, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ceramide-synthase', 'display_name': 'Ceramide synthase', 'score': 0.9396833}, {'id': 'https://openalex.org/keywords/sphingolipid', 'display_name': 'Sphingolipid', 'score': 0.8236153}], 'concepts': [{'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.98462355}, {'id': 'https://openalex.org/C2779237115', 'wikidata': 'https://www.wikidata.org/wiki/Q3958691', 'display_name': 'Ceramide synthase', 'level': 4, 'score': 0.9396833}, {'id': 'https://openalex.org/C61705674', 'wikidata': 'https://www.wikidata.org/wiki/Q410395', 'display_name': 'Sphingolipid', 'level': 2, 'score': 0.8236153}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.76100206}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.7547171}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.744344}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7367065}, {'id': 'https://openalex.org/C2781429003', 'wikidata': 'https://www.wikidata.org/wiki/Q420762', 'display_name': 'Fumonisin B1', 'level': 3, 'score': 0.7281637}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.7025163}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.63530326}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5967368}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.42530242}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2714774}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.065856844}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.051529348}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C84699730', 'wikidata': 'https://www.wikidata.org/wiki/Q422449', 'display_name': 'Mycotoxin', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D053179', 'descriptor_name': 'Caspase 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053179', 'descriptor_name': 'Caspase 7', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053179', 'descriptor_name': 'Caspase 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037341', 'descriptor_name': 'Fumonisins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D037341', 'descriptor_name': 'Fumonisins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014466', 'descriptor_name': 'Ultraviolet Rays', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014466', 'descriptor_name': 'Ultraviolet Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050998', 'descriptor_name': 'bcl-2 Homologous Antagonist-Killer Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050998', 'descriptor_name': 'bcl-2 Homologous Antagonist-Killer Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050998', 'descriptor_name': 'bcl-2 Homologous Antagonist-Killer Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051020', 'descriptor_name': 'bcl-X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051020', 'descriptor_name': 'bcl-X Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051020', 'descriptor_name': 'bcl-X Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.230870', 'pdf_url': 'http://www.jbc.org/article/S0021925820514117/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3091202', 'pdf_url': 'https://europepmc.org/articles/pmc3091202?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091202', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21388949', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.230870', 'pdf_url': 'http://www.jbc.org/article/S0021925820514117/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1482562715', 'https://openalex.org/W1965071591', 'https://openalex.org/W1966452335', 'https://openalex.org/W1968330432', 'https://openalex.org/W1970504457', 'https://openalex.org/W1974747981', 'https://openalex.org/W1975242912', 'https://openalex.org/W1976881265', 'https://openalex.org/W1980792888', 'https://openalex.org/W1984547206', 'https://openalex.org/W1986188880', 'https://openalex.org/W1986684160', 'https://openalex.org/W1990098732', 'https://openalex.org/W1991429239', 'https://openalex.org/W1992215701', 'https://openalex.org/W1993552956', 'https://openalex.org/W1994132984', 'https://openalex.org/W1995926317', 'https://openalex.org/W2000973050', 'https://openalex.org/W2011153884', 'https://openalex.org/W2011491573', 'https://openalex.org/W2012893076', 'https://openalex.org/W2015527403', 'https://openalex.org/W2017649890', 'https://openalex.org/W2017729786', 'https://openalex.org/W2019582253', 'https://openalex.org/W2020466852', 'https://openalex.org/W2022791001', 'https://openalex.org/W2024149904', 'https://openalex.org/W2024996523', 'https://openalex.org/W2026873116', 'https://openalex.org/W2027151723', 'https://openalex.org/W2031934833', 'https://openalex.org/W2032049833', 'https://openalex.org/W2033791588', 'https://openalex.org/W2039122956', 'https://openalex.org/W2044232250', 'https://openalex.org/W2044325325', 'https://openalex.org/W2045064724', 'https://openalex.org/W2045380458', 'https://openalex.org/W2045563337', 'https://openalex.org/W2048689532', 'https://openalex.org/W2049108649', 'https://openalex.org/W2052615972', 'https://openalex.org/W2053858732', 'https://openalex.org/W2056182070', 'https://openalex.org/W2059246206', 'https://openalex.org/W2062250309', 'https://openalex.org/W2062861782', 'https://openalex.org/W2074980090', 'https://openalex.org/W2076875353', 'https://openalex.org/W2077609848', 'https://openalex.org/W2078520816', 'https://openalex.org/W2078702640', 'https://openalex.org/W2087792530', 'https://openalex.org/W2088805436', 'https://openalex.org/W2091766574', 'https://openalex.org/W2093354310', 'https://openalex.org/W2094522158', 'https://openalex.org/W2101575450', 'https://openalex.org/W2102253975', 'https://openalex.org/W2111645679', 'https://openalex.org/W2112237647', 'https://openalex.org/W2126762891', 'https://openalex.org/W2129041175', 'https://openalex.org/W2131811820', 'https://openalex.org/W2134810505', 'https://openalex.org/W2135687585', 'https://openalex.org/W2141347249', 'https://openalex.org/W2144626362', 'https://openalex.org/W2146039419', 'https://openalex.org/W2150048195', 'https://openalex.org/W2155325845', 'https://openalex.org/W2162007544', 'https://openalex.org/W2314083640', 'https://openalex.org/W2418263387', 'https://openalex.org/W4231884716'], 'related_works': ['https://openalex.org/W3174382074', 'https://openalex.org/W2154441783', 'https://openalex.org/W2043218548', 'https://openalex.org/W2041622229', 'https://openalex.org/W2011214340', 'https://openalex.org/W1993904061', 'https://openalex.org/W1971461610', 'https://openalex.org/W1567111656', 'https://openalex.org/W1542941723', 'https://openalex.org/W104784336'], 'abstract_inverted_index': {'The': [0, 16], 'sphingolipid': [1, 89], 'ceramide': [2, 19, 67, 98, 127, 147, 153, 211], 'has': [3, 20], 'been': [4, 21], 'widely': [5], 'implicated': [6], 'in': [7, 23, 33, 69, 123, 131, 154, 230, 234], 'the': [8, 44, 62, 85, 143, 167, 191, 226, 235], 'regulation': [9, 63], 'of': [10, 18, 27, 30, 38, 47, 66, 72, 87, 113, 145, 152, 176, 202, 238], 'programmed': [11, 76, 156, 239], 'cell': [12, 77, 140, 157, 240], 'death': [13], 'or': [14, 119], 'apoptosis.': [15], 'accumulation': [17, 86, 212], 'demonstrated': [22], 'a': [24, 36, 70, 146, 220], 'wide': [25], 'variety': [26], 'experimental': [28], 'models': [29], 'apoptosis': [31, 54], 'and': [32, 40, 50, 64, 95, 109, 130, 204, 213, 225], 'response': [34, 132], 'to': [35, 60, 103, 133, 189, 208], 'myriad': [37], 'stimuli': [39], 'cellular': [41, 126], 'stresses.': [42], 'However,': [43], 'detailed': [45], 'mechanisms': [46], 'its': [48], 'generation': [49, 99], 'regulatory': [51], 'role': [52, 222], 'during': [53], 'are': [55], 'poorly': [56], 'understood.': [57], 'We': [58, 79, 159], 'sought': [59], 'determine': [61], 'roles': [65], 'production': [68], 'model': [71], 'ultraviolet': [73], 'light-C': [74], '(UV-C)-induced': [75], 'death.': [78, 158, 241], 'found': [80, 102, 160, 198], 'that': [81, 161, 199], 'UV-C': [82], 'irradiation': [83], 'induces': [84], 'multiple': [88], 'species': [90], 'including': [91], 'ceramide,': [92], 'dihydroceramide,': [93], 'sphingomyelin,': [94], 'hexosylceramide.': [96], 'Late': [97], 'was': [100, 181, 206], 'also': [101], 'be': [104], 'regulated': [105], 'by': [106], 'Bcl-xL,': [107], 'Bak,': [108], 'caspases.': [110], 'Surprisingly,': [111], 'inhibition': [112], 'de': [114], 'novo': [115], 'synthesis': [116], 'using': [117], 'myriocin': [118], 'fumonisin': [120, 137], 'B1': [121, 138], 'resulted': [122], 'decreased': [124], 'overall': [125], 'levels': [128], 'basally': [129], 'UV-C,': [134], 'but': [135, 170], 'only': [136], 'inhibited': [139], 'death,': [141], 'suggesting': [142], 'presence': [144], 'synthase': [148], '(CerS)-dependent,': [149], 'sphingosine-derived': [150], 'pool': [151, 163], 'regulating': [155, 231], 'this': [162, 195], 'did': [164, 172], 'not': [165], 'regulate': [166, 174], 'mitochondrial': [168], 'pathway,': [169], 'it': [171], 'partially': [173], 'activation': [175], 'caspase-7': [177], 'and,': [178], 'more': [179], 'importantly,': [180], 'necessary': [182], 'for': [183, 194, 223], 'late': [184], 'plasma': [185, 214], 'membrane': [186, 215, 232], 'permeabilization.': [187, 216], 'Attempting': [188], 'identify': [190, 219], 'CerS': [192, 224], 'responsible': [193], 'effect,': [196], 'we': [197], 'combined': [200], 'knockdown': [201], 'CerS5': [203], 'CerS6': [205], 'able': [207], 'decrease': [209], 'long-chain': [210], 'These': [217], 'data': [218], 'novel': [221], 'sphingosine': [227], 'salvage': [228], 'pathway': [229], 'permeability': [233], 'execution': [236], 'phase': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018474075', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-09T10:52:57.258520', 'created_date': '2016-06-24'}