Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1993904061', 'doi': 'https://doi.org/10.1016/s0300-483x(03)00048-9', 'title': 'Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity', 'display_name': 'Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity', 'publication_year': 2003, 'publication_date': '2003-04-24', 'ids': {'openalex': 'https://openalex.org/W1993904061', 'doi': 'https://doi.org/10.1016/s0300-483x(03)00048-9', 'mag': '1993904061', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12699912'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0300-483x(03)00048-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128555845', 'display_name': 'Toxicology', 'issn_l': '0300-483X', 'issn': ['0300-483X', '1879-3185'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079763055', 'display_name': 'Neera V. Gopee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165733156', 'display_name': 'University of Georgia', 'ror': 'https://ror.org/00te3t702', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165733156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Neera V. Gopee', 'raw_affiliation_strings': ['Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens 30602-7389, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens 30602-7389, USA.', 'institution_ids': ['https://openalex.org/I165733156']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111769084', 'display_name': 'Raghubir P. Sharma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165733156', 'display_name': 'University of Georgia', 'ror': 'https://ror.org/00te3t702', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165733156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raghubir P. Sharma', 'raw_affiliation_strings': ['Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens GA 30602-7389, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens GA 30602-7389, USA', 'institution_ids': ['https://openalex.org/I165733156']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3750, 'currency': 'USD', 'value_usd': 3750, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.794, 'has_fulltext': False, 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.586956, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '187', 'issue': '2-3', 'first_page': '239', 'last_page': '250'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11613', 'display_name': 'Phytochemistry and Biological Activities', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C186310378', 'wikidata': 'https://www.wikidata.org/wiki/Q941796', 'display_name': 'Psychological repression', 'level': 4, 'score': 0.5963112}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5764535}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.5699265}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.565765}, {'id': 'https://openalex.org/C2781429003', 'wikidata': 'https://www.wikidata.org/wiki/Q420762', 'display_name': 'Fumonisin B1', 'level': 3, 'score': 0.51962274}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.46410143}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4537095}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43411803}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3399575}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2480326}, {'id': 'https://openalex.org/C84699730', 'wikidata': 'https://www.wikidata.org/wiki/Q422449', 'display_name': 'Mycotoxin', 'level': 2, 'score': 0.12882367}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.09117097}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06391922}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D037341', 'descriptor_name': 'Fumonisins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004794', 'descriptor_name': 'Enzyme Repression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005229', 'descriptor_name': 'Fatty Acids, Monounsaturated', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005229', 'descriptor_name': 'Fatty Acids, Monounsaturated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037341', 'descriptor_name': 'Fumonisins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009183', 'descriptor_name': 'Mycotoxins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D009183', 'descriptor_name': 'Mycotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0300-483x(03)00048-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128555845', 'display_name': 'Toxicology', 'issn_l': '0300-483X', 'issn': ['0300-483X', '1879-3185'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12699912', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1501369263', 'https://openalex.org/W1514113199', 'https://openalex.org/W1524495054', 'https://openalex.org/W1535433473', 'https://openalex.org/W1539477594', 'https://openalex.org/W154215136', 'https://openalex.org/W1567424605', 'https://openalex.org/W1595133660', 'https://openalex.org/W1601124709', 'https://openalex.org/W1862805059', 'https://openalex.org/W192888932', 'https://openalex.org/W1973621780', 'https://openalex.org/W1981103125', 'https://openalex.org/W1981412298', 'https://openalex.org/W1982542439', 'https://openalex.org/W1983172212', 'https://openalex.org/W1992615534', 'https://openalex.org/W2002242163', 'https://openalex.org/W2006743148', 'https://openalex.org/W2008113364', 'https://openalex.org/W2009164208', 'https://openalex.org/W2009993180', 'https://openalex.org/W2013634259', 'https://openalex.org/W20139641', 'https://openalex.org/W2019560179', 'https://openalex.org/W2028663640', 'https://openalex.org/W2031983576', 'https://openalex.org/W2032072281', 'https://openalex.org/W2036039480', 'https://openalex.org/W2036292578', 'https://openalex.org/W2037440671', 'https://openalex.org/W2037514664', 'https://openalex.org/W2049449799', 'https://openalex.org/W2053900021', 'https://openalex.org/W2057399985', 'https://openalex.org/W2058581413', 'https://openalex.org/W2072607078', 'https://openalex.org/W2073347694', 'https://openalex.org/W2084173735', 'https://openalex.org/W2091950558', 'https://openalex.org/W2124167653', 'https://openalex.org/W2126544407', 'https://openalex.org/W2133274096', 'https://openalex.org/W2134466503', 'https://openalex.org/W2157395014', 'https://openalex.org/W2159898367', 'https://openalex.org/W2462558550', 'https://openalex.org/W2477289493', 'https://openalex.org/W4243106150', 'https://openalex.org/W4247723596', 'https://openalex.org/W4252106378', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W891673278', 'https://openalex.org/W3152230514', 'https://openalex.org/W3147138563', 'https://openalex.org/W3092521730', 'https://openalex.org/W2796949944', 'https://openalex.org/W2395219877', 'https://openalex.org/W2366562690', 'https://openalex.org/W2045299745', 'https://openalex.org/W1543402492', 'https://openalex.org/W1540936366'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993904061', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-12-16T15:45:50.822842', 'created_date': '2016-06-24'}