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[93], 'In': [94], 'contrast': [95], 'analogous': [98], 'S108N': [99], 'mutation': [100, 109], 'falciparum': [103], 'DHFR': [104, 206], '(PfDHFR),': [105], 'S117N': [108, 141], 'conferred': [112], '≈4000-': [113], '≈1600-fold': [115], 'increased': [116], 'resistance': [117], 'respectively,': [122], 'PvDHFR.': [127], 'S58R+S117N': [129], 'double': [130], 'was': [133, 159, 172], '10-': [134], '25-fold': [136], 'resistant': [138], 'than': [139, 152], 'inhibitors,': [145], 'also': [147], 'exhibited': [148], 'higher': [149], 'kcat/Km': [150], 'value': [151], 'mutant.': [155], 'antifolate': [157, 214], 'WR99210': [158], 'equally': [160], 'both': [163], 'SP21': [167], '(S58R+S117N)': [168], 'DHFRs,': [170], 'much': [173], 'some': [177], 'mutants.': [181], 'Data': [182], 'on': [183], 'inhibitory': [187], 'constant': [188], 'suggest': [189], 'that': [190, 201], 'P.': [193, 209], 'is': [195], 'susceptible': [196], 'antimalarial': [198], 'antifolates': [199], 'point': [202], 'mutations': [203], 'domain': [207], 'are': [211], 'responsible': [212], 'for': [213], 'resistance.': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2016564233', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-15T18:11:10.328587', 'created_date': '2016-06-24'}