Publication Information

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1260, 1280, 1341, 1479, 1483, 1590, 1595, 1614, 1698, 1709, 1716, 1766, 1865, 1912, 1929, 2003, 2010, 2037, 2078, 2090, 2101, 2121, 2124, 2129, 2132, 2142, 2160, 2166, 2171, 2239, 2254, 2270, 2273, 2278, 2299, 2314, 2332, 2347, 2353, 2367, 2371, 2376, 2382, 2388, 2391, 2407, 2431, 2451, 2458, 2469, 2493, 2520, 2523, 2590, 2594, 2602, 2608, 2627, 2630, 2639, 2656, 2664, 2672, 2678, 2701, 2708, 2717, 2721, 2725, 2737, 2747, 2753, 2760, 2777, 2787, 2790, 2795, 2810, 2813, 2819, 2832, 2835, 2844, 2858, 2869, 2985, 3002, 3008, 3017, 3154, 3162, 3188, 3199, 3206, 3210, 3213, 3216, 3260, 3295, 3298, 3305, 3312, 3332, 3353, 3394, 3397, 3405, 3410, 3423, 3427, 3433, 3439, 3445, 3448, 3457, 3464, 3469, 3475, 3483, 3487, 3491, 3497, 3500, 3510, 3519, 3526, 3553, 3557, 3573, 3600, 3606, 3624, 3630, 3639, 3643, 3651, 3664, 3681, 3691, 3700, 3703, 3731, 3772, 3778, 3791, 3815, 3827, 3832, 3844, 3850, 3854, 3874, 3890, 3895, 3908, 3921, 3925, 3945, 3954, 3959, 3962, 3983, 4002, 4014, 4032, 4038, 4042, 4054, 4067, 4077, 4088, 4094, 4119, 4125, 4172, 4187, 4201, 4204, 4216, 4221, 4255, 4267, 4270, 4275, 4303, 4321, 4328, 4336, 4342, 4376, 4383, 4418, 4422, 4436, 4451, 4460, 4463, 4467, 4478, 4488, 4513, 4518, 4534, 4537, 4543, 4574, 4585, 4599, 4605, 4609, 4614, 4636, 4645, 4716], 'heterogeneous': [8, 144, 482], 'nuclear': [9, 145, 483, 500, 1393, 1430, 1554, 1704, 1728, 1852, 1936, 2071, 2097, 2305, 2404, 2470, 2697, 3181, 3695, 3802, 4310, 4377], 'ribonucleoprotein': [10, 146, 383, 584], '(hnRNP)': [11, 147], 'H': [12, 79, 92, 148, 215, 228, 893, 944, 1018, 1160, 1179, 1699, 1796, 2126, 2134, 2183, 2275, 2282, 2368, 2393, 2411, 2436, 2489, 2525, 2541, 2599, 2632, 2641, 2658, 2688, 2713, 2744, 2769, 2792, 2797, 2815, 3308, 3501, 3520, 3590, 3653, 3683, 3705, 3800, 3940, 4272, 4305, 4323, 4344, 4372, 4389, 4438, 4469, 4511, 4603], 'protein': [13, 93, 149, 229, 299, 2283, 3917, 3966], 'family': [14, 80, 94, 150, 216, 230, 549, 586, 692, 1019, 1186, 1700, 2011, 2135, 2243, 2276, 2284, 2369, 2394, 2526, 2633, 2642, 2659, 2689, 2793, 2816, 3309, 3521, 3591, 3684, 3706, 3941, 3967, 3992, 4273, 4324, 4439, 4470], 'to': [15, 151, 291, 311, 358, 442, 531, 724, 737, 896, 913, 949, 1040, 1097, 1130, 1301, 1367, 1511, 1594, 1769, 1952, 2077, 2113, 2137, 2170, 2346, 2352, 2373, 2495, 2601, 2635, 2680, 2685, 2691, 2752, 2818, 2826, 3023, 3225, 3246, 3259, 3328, 3339, 3437, 3493, 3541, 3593, 3623, 3629, 3663, 3676, 3849, 3873, 3889, 3902, 3930, 4036, 4162, 4165, 4274, 4284, 4367, 4413, 4417, 4512, 4529, 4540, 4641, 4715], 'determine': [16, 152, 2677, 3677, 4285], 'their': [17, 153, 443, 2258, 4500], 'RNA': [18, 154, 801, 1065, 1148, 1389, 1487, 1505, 1541, 1597, 1712, 1719, 1898, 2117, 2349, 2694, 2762, 2778, 2822, 3565, 3596, 3765, 3810, 4143], 'binding': [19, 155, 733, 959, 985, 1087, 3009, 3022, 3250, 3310, 3529, 4117, 4265, 4577, 4712], 'specificities': [20, 156, 2140], 'and': [21, 35, 49, 74, 157, 171, 185, 210, 369, 376, 405, 429, 432, 445, 450, 455, 504, 509, 526, 603, 616, 688, 708, 712, 719, 730, 812, 836, 871, 894, 979, 1027, 1074, 1101, 1167, 1197, 1208, 1214, 1273, 1325, 1348, 1375, 1465, 1485, 1492, 1589, 1609, 1623, 1650, 1675, 1686, 1715, 1778, 1795, 1839, 1864, 1878, 1924, 1974, 1996, 2001, 2015, 2028, 2033, 2073, 2084, 2338, 2360, 2412, 2425, 2439, 2441, 2446, 2490, 2517, 2542, 2544, 2598, 2616, 2620, 2660, 2712, 2728, 2736, 2743, 2770, 2775, 2807, 2851, 2854, 2865, 2877, 2883, 2998, 3164, 3243, 3253, 3348, 3375, 3382, 3388, 3426, 3536, 3619, 3635, 3669, 3726, 3749, 3755, 3767, 3798, 3838, 3871, 3957, 3996, 4024, 4081, 4100, 4180, 4208, 4232, 4307, 4331, 4360, 4399, 4408, 4485, 4494, 4496, 4522, 4604, 4639, 4706, 4718], 'roles': [22, 158, 621, 4461], 'in': [23, 51, 62, 159, 187, 198, 288, 529, 596, 609, 703, 1022, 1095, 1163, 1191, 1292, 1340, 1417, 1544, 1556, 1600, 1730, 1803, 1854, 1869, 1918, 1935, 2294, 2385, 2481, 2669, 2785, 2839, 3014, 3179, 3205, 3297, 3404, 3432, 3453, 3539, 3661, 3771, 3814, 3826, 3843, 3894, 3924, 3968, 3977, 3981, 4076, 4087, 4169, 4250, 4257, 4261, 4335, 4341, 4375, 4471, 4487, 4502, 4631, 4702], 'splicing': [24, 64, 86, 97, 134, 160, 200, 222, 233, 270, 273, 355, 452, 463, 467, 471, 475, 506, 528, 551, 595, 728, 742, 912, 952, 983, 1023, 1035, 1090, 1103, 1114, 1154, 1165, 1413, 1920, 1939, 2546, 2840, 3005, 3166, 3174, 3183, 3204, 3221, 3240, 3248, 3324, 3341, 3380, 3467, 3504, 3524, 3571, 3601, 3689, 3738, 3779, 3821, 3841, 3859, 3878, 3933, 3952, 3969, 4050, 4258, 4472, 4492, 4503, 4531, 4618, 4643, 4691], 'regulation.': [25, 161, 4473], 'Our': [26, 162], 'data': [27, 163, 2479, 3670, 3936], 'indicate': [28, 164, 3937, 4432], 'that': [29, 77, 124, 165, 213, 260, 294, 309, 385, 418, 518, 542, 601, 699, 1135, 1182, 1990, 2002, 2023, 2099, 2252, 2363, 2384, 2460, 2487, 2519, 2651, 2879, 3158, 3302, 3516, 3552, 3586, 3613, 3916, 3938, 3958, 4215, 4392, 4433, 4598, 4626, 4690], 'hnRNPs': [30, 166, 617, 683, 715, 892, 1069, 1157, 1696, 1838, 2024, 2169, 2182, 2420, 2488, 2540, 2612, 2705, 3498, 3517, 3614, 3721, 3735, 3776, 3835, 4304, 4322, 4343, 4396, 4481, 4707], 'H,': [31, 167, 684, 716, 1070, 1270, 1774, 1992, 2025, 2336, 2421, 3255, 3615, 3722, 3836, 3869, 3986, 4397, 4482], 'H′,': [32, 168, 685, 717, 1071, 1775, 1993, 2026, 2422, 3616, 3723, 4483], 'F,': [33, 169, 686, 1072, 1272, 1674, 1776, 1994, 2027, 2337, 2423, 2771, 3617, 3724, 3837, 3870, 4398], '2H9,': [34, 170, 687, 718, 1073, 1777, 1995, 2424, 3618, 3725, 4484], 'GRSF-1': [36, 172, 689, 1075, 1687, 1997, 2426, 3620, 3727, 3893, 3910], 'bind': [37, 173, 2375], 'consensus': [39, 114, 175, 250, 1078, 1085, 1110, 2143, 2289, 2315, 2377, 2837, 4575], 'motif': [40, 176, 1066, 1088, 2291, 2838, 4578], 'DGGGD': [41, 177, 1086, 2144, 2265, 2290, 2316, 2836, 3156, 4576], '(where': [42, 178, 2146], 'D': [43, 179, 2147], 'is': [44, 180, 274, 356, 381, 1010, 1029, 2012, 2148, 2649, 2823, 2855, 2872, 2981, 2992, 3234, 3315, 3451, 3505, 3514, 3550, 3603, 3913, 3948, 3999, 4009, 4031, 4058, 4103, 4114, 4175, 4596, 4613], 'U,': [45, 181], 'G,': [46, 182, 2150], 'or': [47, 183, 502, 1025, 2151, 2158, 2234, 2248, 2319, 2798, 3366, 3544, 3562, 3736], 'A)': [48, 184], 'aggregate': [50, 186], 'a': [52, 66, 188, 202, 281, 382, 398, 691, 897, 1113, 1145, 1188, 1351, 1361, 1418, 1461, 1468, 1545, 1557, 1731, 2115, 2174, 2288, 2295, 2323, 2528, 2536, 2692, 3237, 3402, 3594, 3710, 3763, 3820, 3865, 3904, 3978, 4085, 4245, 4352, 4393, 4414, 4686, 4699], 'multimeric': [53, 189], 'complex.': [54, 190, 2325, 2530, 2675, 4044, 4128, 4454], 'We': [55, 191, 2019, 2326, 3152], 'role': [58, 194, 1190, 2833, 3403], 'these': [60, 128, 196, 264, 735, 2461, 3578, 4287, 4620], 'proteins': [61, 197, 615, 698, 736, 1039, 1289, 1371, 1591, 1866, 2074, 2240, 2343, 2462, 2624, 2757, 2801, 3021, 3640, 4288, 4373, 4390], 'substrate': [67, 101, 122, 203, 237, 258, 1115, 2067, 2693, 2779, 2979, 3489, 3527, 3602, 3632, 3713, 3766, 3787, 3809, 3956, 4218, 4228, 4299], 'derived': [68, 204, 1116, 1203, 2856, 3598], 'from': [69, 205, 280, 392, 1092, 1117, 1204, 1365, 1703, 2593, 2707, 2720, 2857, 3223, 3326, 3599, 3642, 3648, 3699, 3730, 3777], 'HIV-1': [71, 207, 873, 1119, 2859, 3395, 3459], 'tat': [72, 208, 1120, 2860, 2870, 2989, 3411], 'gene': [73, 209, 822, 910, 2861, 2871, 3412, 3480], 'have': [75, 211, 700, 721, 2020, 2472, 2492, 2880, 3490, 3886, 4364, 4505, 4624], 'shown': [76, 212, 600, 723, 948, 2022, 4168, 4528, 4625], 'hnRNP': [78, 91, 214, 227, 943, 1017, 1178, 1269, 1271, 1274, 1619, 1621, 1624, 1660, 1671, 1673, 1773, 1793, 1991, 2125, 2133, 2274, 2312, 2335, 2365, 2392, 2410, 2413, 2435, 2442, 2524, 2596, 2631, 2640, 2657, 2710, 2741, 2768, 2791, 2796, 2814, 3011, 3251, 3254, 3307, 3589, 3652, 3682, 3704, 3799, 3939, 3991, 4271, 4371, 4388, 4437, 4468, 4510, 4602, 4704], 'are': [82, 218, 316, 408, 413, 420, 439, 539, 575, 607, 1998, 2302, 2480, 3159, 3621, 3928, 3971, 4289, 4440, 4628], 'required': [83, 219, 409, 1152, 3316, 3568, 3686, 3929, 3949, 4115, 4290, 4441], 'for': [84, 220, 410, 423, 1153, 1316, 1454, 1478, 1497, 1797, 1841, 2089, 2141, 2607, 2733, 2767, 3317, 3358, 3569, 3687, 3950, 4116, 4280, 4291, 4442, 4450, 4499], 'efficient': [85, 221, 2784, 3318, 3688, 3951, 4292], 'substrate.': [89, 225, 2172, 3574, 3693], 'The': [90, 226, 301, 379, 571, 732, 1268, 1285, 1296, 1370, 1446, 1537, 1831, 1967, 2341, 2978, 3231, 3320, 3350, 3785, 3808, 4028, 4045, 4109, 4154, 4226, 4248, 4297], 'activated': [96, 232], 'viral': [100, 236, 713, 2034, 3415, 3446, 3479], 'by': [102, 238, 277, 958, 984, 1015, 1068, 1156, 1245, 1253, 1265, 1323, 1627, 1636, 1653, 1663, 1678, 1689, 1706, 2064, 2120, 2178, 2232, 2264, 2430, 2450, 2759, 2874, 3006, 3249, 3507, 3528, 3583, 3605, 3707, 3761, 3863, 4011, 4041, 4066, 4178, 4184, 4318, 4532, 4698, 4711], 'promoting': [103, 239], 'formation': [105, 241, 3998, 4012, 4075, 4095, 4133, 4202, 4252, 4294, 4314, 4403, 4443], 'ATP-dependent': [107, 243, 1192, 1930, 4034, 4205, 4445], 'spliceosomal': [108, 244, 2621, 2665, 4073, 4131, 4223, 4293, 4405, 4446], 'complexes.': [109, 245, 4210], 'Mutational': [110, 246], 'analysis': [111, 247, 1168, 1988, 3585], 'six': [113, 249], 'motifs': [115, 129, 251, 265, 1111, 1128, 3157], 'present': [116, 252, 3160, 3431, 3485], 'within': [117, 253, 900, 1144, 2095, 2671, 2988, 3161, 3236, 3393, 3486], 'intron': [119, 255, 814, 4646], 'indicated': [123, 259, 1181], 'only': [125, 261, 1123, 3409, 4355], 'one': [126, 262, 2852, 3303, 4419], 'acts': [130, 266], 'as': [131, 267, 1076, 1212, 1397, 1432, 1516, 1891, 2320, 3187, 3417, 3438, 3741, 4167, 4295], 'an': [132, 268, 960, 986, 1302, 2328, 2466, 3564], 'intronic': [133, 269, 430, 451, 466, 474, 505, 738, 987, 3334, 4632], 'enhancer.': [135, 271], 'Alternative': [272], 'process': [276], 'which': [278, 1016, 2681, 2847, 3219, 3256, 3987, 4020, 4092, 4192, 4703], 'exons': [279, 2850], 'primary': [282], 'transcript': [283], '(pre-mRNA)': [284], 'can': [285, 370, 514, 2256, 3472, 3522, 4158, 4219, 4240, 4581], 'be': [286, 1131, 1151, 2636, 4159, 4241, 4582, 4696], 'spliced': [287, 318, 903, 1484, 2983, 3191, 3789, 3812, 4105, 4592], 'different': [289, 298, 4497], 'arrangements': [290], 'yield': [292], 'mRNAs': [293, 3421], 'will': [295], 'produce': [296], 'functionally': [297], 'variants.': [300], 'sequencing': [302], 'human': [305, 486], 'genome': [306, 368, 3396, 3447], 'has': [307, 599, 945, 2370, 2534, 4476, 4526], 'revealed': [308, 3301], 'up': [310], '75%': [312], 'multiexon': [314], 'genes': [315, 598, 3416], 'alternatively': [317, 902], '(1Johnson': [319], 'J.M.': [320], 'Castle': [321], 'J.': [322, 644, 647, 881, 927, 993, 1528, 1655, 1665, 1691, 2044, 2212, 2215, 2890, 2893, 2938, 2960, 3032, 3035, 3083, 3086, 3104, 3106, 3108, 3118, 3144, 3277], 'Garrett-Engele': [323], 'P.': [324, 668, 856, 1666, 2553], 'Kan': [325], 'Z.': [326], 'Loerch': [327], 'P.M.': [328], 'Armour': [329], 'C.D.': [330, 964], 'Santos': [331], 'R.': [332, 336, 824, 966, 1639, 1895, 1897, 2569, 2575, 3081, 4140, 4142], 'Schadt': [333], 'E.E.': [334], 'Stoughton': [335], 'Shoemaker': [337], 'D.D.': [338], 'Science.': [339, 630, 2198], '2003;': [340], '302:': [341], '2141-2144Crossref': [342], 'PubMed': [343, 566, 634, 658, 678, 758, 777, 807, 833, 866, 885, 938, 974, 1004, 1053, 1231, 1532, 1904, 2055, 2202, 2226, 2512, 2563, 2585, 2904, 2923, 2943, 2971, 3046, 3065, 3092, 3112, 3133, 3149, 3288, 4149, 4568, 4657, 4680], 'Scopus': [344, 567, 635, 659, 679, 759, 778, 808, 867, 886, 939, 975, 1005, 1054, 1232, 1533, 1905, 2056, 2203, 2227, 2513, 2564, 2586, 2905, 2924, 2944, 2972, 3047, 3066, 3093, 3113, 3134, 3289, 4150, 4569, 4658, 4681], '(1196)': [345], 'Google': [346, 569, 637, 661, 681, 761, 780, 810, 834, 869, 888, 941, 977, 1007, 1056, 1234, 1409, 1444, 1535, 1907, 2058, 2205, 2229, 2515, 2566, 2588, 2907, 2926, 2946, 2974, 3049, 3068, 3095, 3115, 3136, 3150, 3291, 4152, 4571, 4660, 4683], 'Scholar).': [347, 570, 682, 889, 942, 1008, 1057, 1235, 1410, 1445, 1536, 1908, 2059, 3151, 3292, 4153, 4572, 4684], 'A': [348, 2233, 2864, 2997, 4029, 4211, 4231, 4357, 4407], 'clear': [349], 'understanding': [350], 'mechanisms': [353, 592, 1014], 'regulating': [354, 593, 1132, 3466, 4617], 'key': [357, 1189], 'our': [359, 2110], 'comprehension': [360], 'complex': [363, 384, 1171, 2102, 2643, 3985, 4030, 4035, 4057, 4074, 4132, 4157, 4174, 4234, 4239, 4251, 4313, 4356], 'regulation': [364, 433, 3406, 4504], 'eukaryotic': [367], 'provide': [371], 'us': [372], 'with': [373, 516, 579, 726, 1137, 1312, 1327, 1360, 1467, 1611, 1765, 1788, 1847, 1880, 2069, 2277, 2406, 2416, 2434, 2465, 2475, 2483, 2638, 2696, 2716, 3209, 4254, 4302, 4386, 4421, 4542], 'new': [374, 2296], 'diagnostic': [375], 'therapeutic': [377], 'tools.': [378], 'spliceosome': [380, 1170, 1193], 'removes': [386], 'non-coding': [387], 'intervening': [388, 2467], 'sequences': [389, 417, 431, 513, 541, 606, 739, 3026, 4633, 4713], 'called': [390], 'introns': [391, 4694], 'precursor': [393], 'mRNA.': [394], 'Within': [395], 'intron,': [397, 2853], '3′': [399, 816, 3262, 4025], 'splice': [400, 403, 524, 788, 817, 917, 1099, 1263, 3263, 3429, 3442, 3461, 4006, 4026, 4090, 4112, 4189, 4515, 4545, 4587, 4611, 4637], 'site,': [401, 404, 4091], '5′': [402, 787, 916, 1262, 3428, 3441, 3460, 4023, 4089, 4111, 4188, 4514, 4544, 4586, 4610, 4717], 'branch': [406], 'site': [407, 789, 818, 918, 1264, 3264, 3430, 4113, 4190, 4516, 4546, 4588, 4612], 'splicing.': [411, 435, 3319], 'These': [412, 511, 2478, 3935, 4430], 'short,': [414], 'loosely': [415], 'conserved': [416, 1256], 'alone': [419, 2453], 'not': [421, 1030, 2351, 2449, 2645, 3202, 3337, 3378, 3408, 3628, 3671, 3769, 3848, 3881, 3972, 4104, 4183, 4316, 4340, 4411, 4449], 'sufficient': [422], 'proper': [425, 520, 1142, 3570], 'recognition': [426, 521], 'exonic': [428, 449, 462, 470, 503, 961], 'Additional': [436], 'regulatory': [437, 512, 898, 1139, 3546], 'elements': [438, 612, 1140], 'classified': [440], 'according': [441], 'location': [444, 1094, 3351, 3371, 3392], 'function,': [446], 'because': [447, 3361], 'either': [448], 'enhancers': [453, 729, 4493], '(ESEs': [454], 'ISEs)': [456], '2The': [457], 'abbreviations': [458], 'used': [459], 'are:': [460], 'ESE,': [461], 'enhancer;': [464, 468], 'ISE,': [465], 'ESS,': [469], 'silencer;': [472, 476], 'ISS,': [473], 'SR': [477, 614, 1617, 2618, 3020, 3742], 'family,': [478, 3654], 'serine/arginine-rich': [479, 547], 'family;': [480], 'hnRNP,': [481], 'ribonucleoprotein;': [484], 'HIV-1,': [485], 'immunodeficiency': [487], 'virus,': [488], 'type': [489, 3626], '1;': [490], 'Ni-NTA,': [491], 'nickel': [492, 1352], 'nitrilotriacetic': [493, 1353], 'acid;': [494], 'RAC,': [495], 'RNA-affinity': [496, 1489, 1498], 'chromatography;': [497], 'snRNP,': [498], 'small': [499], 'ribonucleoprotein.': [501], 'silencers': [507], '(ESSs': [508], 'ISSs).': [510], 'interact': [515, 725, 2395, 4541], 'factors': [517, 2547, 3561, 3657], 'promote': [519], 'sites': [525, 1100, 4638], 'regulate': [527, 3247, 4530], 'response': [530, 3662], 'physiological': [532], 'stimuli.': [533], 'Among': [534], 'best': [536, 572], 'characterized': [537, 2884, 3239, 4580], 'ESEs': [538, 2876], 'purine-rich': [540], 'recruit': [543, 2268, 3494], '(SR)': [548], 'activators': [552], '(2Blencowe': [553], 'B.J.': [554], 'Trends': [555], 'Biochem.': [556], 'Sci.': [557, 4673], '2000;': [558, 996], '25:': [559], '106-110Abstract': [560], 'Full': [561, 563, 653, 655, 933, 935, 999, 1001, 2050, 2052, 2221, 2223, 2899, 2901, 2966, 2968, 3041, 3043, 3128, 3130, 3283, 3285], 'Text': [562, 564, 654, 656, 934, 936, 1000, 1002, 2051, 2053, 2222, 2224, 2900, 2902, 2967, 2969, 3042, 3044, 3129, 3131, 3284, 3286], 'PDF': [565, 657, 937, 1003, 2054, 2225, 2903, 2970, 3045, 3132, 3287], '(537)': [568], 'known': [573, 1011], 'ESSs': [574, 2878], 'dependent': [576], 'on': [577, 1460, 1604, 1873, 1954, 1959, 2031], 'interaction': [578, 1136, 2538], 'heterogenous': [583], 'A/B': [585], '(hnRNPs': [587], 'A/B).': [588], 'Dissection': [589], 'alternative': [594], 'several': [597, 2611, 2875, 3990, 4590], 'positive': [602], 'negative': [604], 'cis-acting': [605], 'organized': [608], 'multipartite': [610], 'control': [611, 1104, 1155, 1717, 2354, 3474, 3764], 'where': [613], 'often': [618], 'play': [619, 1187, 3401], 'counteracting': [620], '(3Caceres': [622, 2190], 'J.F.': [623, 924, 2191, 2571], 'Stamm': [624, 2192], 'S.': [625, 2193, 2933, 2949, 3075, 3102, 3266, 4665, 4675], 'Helfman': [626, 967, 2194], 'D.M.': [627, 968, 2195], 'Krainer': [628, 1401, 1436, 1523, 2196, 3121], 'A.R.': [629, 1402, 1437, 1524, 2197, 3122], '1994;': [631, 1228, 2199, 2920, 3062], '265:': [632, 2200], '1706-1709Crossref': [633, 2201], '(564)': [636, 2204], 'Scholar,': [638, 662, 762, 2206, 2567, 2908, 2927, 2947, 3050, 3069, 3096, 3116, 3137, 4661], '4Zahler': [639, 2207], 'A.M.': [640, 879, 1043, 1526, 2043, 2208, 2886, 3028], 'Damgaard': [641, 2209, 2887, 3029, 3099], 'C.K.': [642, 2210, 2888, 3030, 3100], 'Kjems': [643, 2211, 2889, 3031, 3105], 'Caputi': [645, 2213, 2891, 3033], 'M.': [646, 828, 877, 1520, 2041, 2214, 2577, 2892, 2929, 2931, 3034, 4550, 4557], 'Biol.': [648, 674, 773, 862, 928, 994, 1049, 1227, 1405, 1440, 2045, 2216, 2508, 2559, 2581, 2894, 2919, 2961, 3036, 3061, 3088, 3278, 4653], 'Chem.': [649, 929, 995, 2046, 2217, 2895, 2962, 3037, 3279], '2004;': [650, 2218, 2896, 2940, 3038, 4565, 4677], '279:': [651, 2219, 2897, 3039], '10077-10084Abstract': [652, 2220, 2898, 3040], '(112)': [660, 2228, 2906, 3048], '5Han': [663], 'K.': [664, 852, 2549], 'Yeo': [665, 853, 2550], 'G.': [666, 854, 1629, 2551, 4663], 'An': [667, 855, 2552], 'Burge': [669, 857, 2554, 4668], 'C.B.': [670, 858, 2555, 4669], 'Grabowski': [671, 859, 2556], 'P.J.': [672, 860, 2557], 'PLoS': [673, 861, 2558, 2580], '2005;': [675, 863, 930, 2560], '3:': [676, 864, 2561], 'e158Crossref': [677, 865, 2562], '(129)': [680, 868, 2565], 'constitute': [690], 'highly': [694], 'homologous,': [695], 'ubiquitously': [696], 'expressed': [697, 1291], 'been': [701, 722, 947, 2473, 2881, 3887, 4365, 4506, 4527], 'implicated': [702, 4477], 'splicing,': [704, 1133, 4281], 'polyadenylation,': [705], 'capping,': [706], 'export,': [707], 'translation': [709], 'cellular': [711, 2032, 2103], 'mRNAs.': [714], 'F': [720, 895, 1794, 2414, 2443, 2491, 2543, 2597, 2711, 2742, 2799, 4486], 'both': [727, 951, 2734, 4491], 'silencers.': [731], 'activates': [740, 3004], 'neural-specific': [741], 'c-src': [745], 'mRNA': [746], '(6Min': [747], 'H.': [748, 2937], 'Chan': [749], 'R.C.': [750], 'Black': [751, 769, 2504], 'D.L.': [752, 770, 2505], 'Genes': [753, 969], 'Dev.': [754, 970], '1995;': [755], '9:': [756], '2659-2671Crossref': [757], '(171)': [760], '7Chou': [763], 'M.Y.': [764, 2499], 'Rooke': [765, 2500], 'N.': [766, 2501], 'Turck': [767, 2502], 'C.W.': [768, 2503], 'Mol.': [771, 1225, 1404, 1439, 2506, 2917, 3059, 3087, 3123, 4651], 'Cell.': [772, 1226, 2507, 2918, 3060, 3124, 4652], '1999;': [774, 971, 1050, 1406, 1441, 1529, 1901, 2509, 3146, 4146], '19:': [775, 2510], '69-77Crossref': [776, 2511], '(215)': [779, 2514], 'Scholar),': [781, 835, 978, 2589], 'elicits': [782], 'use': [783], 'TRα2-specific': [786], 'thyroid': [792], 'hormone': [793], 'receptor': [794, 849], '(8Hastings': [795], 'M.L.': [796], 'Wilson': [797], 'C.M.': [798, 1224, 2916, 2957, 3058, 3143, 3274], 'Munroe': [799], 'S.H.': [800], '(N.': [802, 1899, 4144], 'Y.).': [803, 1900, 4145], '2001;': [804, 2047, 2963, 3109, 3125, 3280], '7:': [805], '859-874Crossref': [806], '(63)': [809], 'Scholar)': [811, 870, 2230, 2516, 2975], '2': [815, 1842, 4525], 'THPO': [821], '(9Marcucci': [823], 'Baralle': [825, 4549, 4554, 4560], 'F.E.': [826, 4561], 'Romano': [827, 4556], 'Nucleic': [829, 4562], 'Acids': [830, 4563], 'Res.': [831, 4564], '2006;': [832, 2582], 'promotes': [837, 911], 'inclusion': [838], 'CI': [841], 'exon': [842, 874, 905, 2990, 3425, 4520, 4524], 'N-methyl-d-aspartic': [845], 'acid-type': [846], 'glutamate': [847], 'R1': [848], '(GRIN1)': [850], '(5Han': [851, 2548], '6D': [875], '(10Caputi': [876], 'Zahler': [878, 1525, 2042], 'EMBO': [880, 1527, 3107], '2002;': [882, 3089], '21:': [883], '845-855Crossref': [884], '(103)': [887], 'Binding': [890, 4508], 'element': [899, 988], 'coding': [904], '1': [906, 1313, 1368, 2359, 3634, 3754], 'bcl-x': [909], 'bcl-xs-specific': [915], '(11Garneau': [919], 'D.': [920, 1220, 1680, 2912, 3054, 3077, 4555], 'Revil': [921], 'T.': [922], 'Fisette': [923, 2570], 'Chabot': [925, 2578], 'B.': [926, 2579, 4667], '280:': [931], '22641-22650Abstract': [932], '(169)': [940, 976], 'also': [946, 3914], 'inhibit': [950], 'rat': [955], 'β-tropomyosin': [956], 'gene,': [957], 'silencer': [962, 3241], '(12Chen': [963], 'Kobayashi': [965], '13:': [972], '593-606Crossref': [973], 'Rous': [980], 'sarcoma': [981], 'virus': [982], '(13Fogel': [989], 'B.L.': [990], 'McNally': [991], 'M.T.': [992], '275:': [997], '32371-32378Abstract': [998], '(47)': [1006], 'Little': [1009], 'act': [1021], 'silencing': [1024], 'activation,': [1026], 'it': [1028, 2307, 2648, 3244, 3513, 3549, 4102, 4595], 'understood': [1031], 'whether': [1032, 1083, 2310, 3678, 4286], 'basal': [1034], 'machinery': [1036, 2666], 'requires': [1037, 4021], 'such': [1038, 3740], 'function': [1041, 4710], '(14Krecic': [1042], 'Swanson': [1044], 'M.S.': [1045], 'Curr.': [1046], 'Opin.': [1047], 'Cell': [1048], '11:': [1051], '363-371Crossref': [1052], '(717)': [1055], 'work,': [1060, 4457], 'identified': [1062, 4160], 'minimal': [1064], 'recognized': [1067, 2119], 'sequence': [1079, 2038, 2118, 2145, 2317, 2355], 'DGGGD.': [1080], 'To': [1081, 2399, 2456, 2676, 2830, 3575, 4060], 'evaluate': [1082], 'affects': [1089], 'independently': [1091, 2374], 'its': [1093, 3359, 3362, 3369, 3391, 3997, 4163, 4361], 'respect': [1096, 3540], 'other': [1102, 1138, 2545, 2625, 2661, 3333, 3414, 3542, 3560, 3656, 3734, 3919], 'elements,': [1105], 'systematically': [1107], 'mutated': [1108, 2993, 3153, 3631], 'gene.': [1121], 'Surprisingly,': [1122], 'two': [1124, 2007, 2849, 4046], 'out': [1125, 1890, 3178], 'eight': [1127, 2179, 3155], 'appeared': [1129, 2634], 'suggesting': [1134], 'and/or': [1141], 'positioning': [1143], 'higher': [1146], 'order': [1147], 'structure': [1149, 3567], 'may': [1150, 2667, 4709], 'family.': [1161, 2127, 3502], 'Furthermore,': [1162], 'vitro': [1164, 1412, 3173], 'assays': [1166, 2301, 2715, 2735], 'formation,': [1172, 4235], 'following': [1173, 1615, 2159], 'depletion': [1174, 3774, 4319], 'add-back': [1175], 'individual': [1177], 'proteins,': [1180, 1618, 2619, 3743], 'formation.': [1194], 'Plasmid': [1195], 'Construction': [1196], 'Protein': [1198], 'Preparation—Splicing': [1199], 'reporter': [1200], 'plasmids': [1201, 1206], 'were': [1202, 1243, 1277, 1290, 1299, 1321, 1338, 1358, 1372, 1385, 1395, 1415, 1449, 1458, 1475, 1501, 1508, 1542, 1586, 1598, 1701, 1763, 1786, 1834, 1859, 1867, 1888, 1916, 1933, 1957, 1979, 2081, 2344, 2427, 2463, 2731, 3176, 3685, 3697, 3728, 3744, 3759, 3900], 'pTat12': [1207, 2845, 2980, 3163, 3434], 'pTat12ESSMut': [1209, 1261], 'previously': [1210, 1517, 1892, 2021, 3238], 'described': [1211, 1398, 1433, 1518, 1893], 'pHS1-X': [1213], 'pΔESS10,': [1215], 'respectively': [1216], '(15Amendt': [1217], 'B.A.': [1218, 2910, 3052], 'Hesslein': [1219, 2911, 3053], 'Chang': [1221, 2913, 3055], 'L.J.': [1222, 2914, 3056], 'Stoltzfus': [1223, 2915, 2956, 3057, 3142, 3273], '14:': [1229, 2921, 3063], '3960-3970Crossref': [1230, 2922, 3064], '(125)': [1233, 2925, 3067], 'Constructs': [1236], 'carrying': [1237, 4186], 'mutations': [1239, 3170, 3197], 'G-runs': [1242, 2255, 3200, 3296, 3335, 3484, 4627], 'obtained': [1244, 1252, 4420], 'PCR': [1246], 'site-directed': [1247, 1266], 'mutagenesis.': [1248, 1267], 'Construct': [1249], 'pTat12ESSMut-5′M': [1250], 'was': [1251, 1949, 1970, 2062, 2308, 2605, 2749, 2780, 3185, 3788, 3811, 3823, 3861, 3880, 4064, 4278, 4300, 4315, 4358], 'mutating': [1254], 'GT': [1257], 'dinucleotide': [1258], '2H9': [1275, 1661, 2029, 2339, 3839, 3872, 4400], 'cDNAs': [1276], 'cloned': [1278], 'into': [1279], 'expression': [1281, 3476], 'vector': [1282], 'PrsetB': [1283], '(Invitrogen).': [1284], 'recombinant': [1286, 2334, 2342, 2408, 3905, 4387], 'N-terminal': [1287], 'histidine-tagged': [1288, 1792, 2409], 'Escherichia': [1293], 'coli': [1294], 'BL21(DE3).': [1295], 'bacterial': [1297], 'cells': [1298, 1320], 'grown': [1300], 'optical': [1303], 'density': [1304], '0.6': [1306], 'at': [1307, 1451, 1800, 1844, 1984, 3944, 4584, 4608], '600': [1308], 'nm': [1309], 'before': [1310], 'induction': [1311], 'mm': [1314, 1329, 1564, 1574, 1577, 1580, 1583, 1738, 1748, 1751, 1754, 1757, 1760, 1810, 1820, 1823, 1826, 1829, 1972, 1976], 'isopropyl-b-d-thiogalactopy-ranoside': [1315], '3': [1317, 2438, 4521], 'h.': [1318, 1456], 'Induced': [1319], 'pelleted': [1322], 'centrifugation': [1324], 'washed': [1326, 1835, 1861], '50': [1328, 1971, 1975], 'Tris-HCl': [1330], '(pH': [1331], '8.0)': [1332], 'containing': [1333, 1424, 1539, 1548, 1724, 2036, 3907], '0.1': [1334, 1570, 1744, 1816], 'm': [1335, 1344, 1571, 1745, 1817], 'NaCl.': [1336], 'Pellets': [1337], 'dissolved': [1339], 'same': [1342, 2726, 3851], '6': [1343, 1366], 'urea': [1345, 1363], 'buffer,': [1346], 'lysed,': [1347], 'loaded': [1349, 1958, 2745], 'onto': [1350, 2287, 2746], 'acid': [1354, 1513], '(Ni-NTA)': [1355], 'column.': [1356], 'Proteins': [1357], 'refolded': [1359], 'linear': [1362], 'gradient': [1364], 'm.': [1369], 'then': [1373, 1587, 1860], 'eluted': [1374, 1599, 1868, 2083, 2592, 2706, 2719, 3641], 'dialyzed.': [1376], 'Vitro': [1378], 'Pre-mRNA': [1379], 'Splicing': [1380, 1473, 1721, 2867], 'Assays—Capped,': [1381], '32P-labeled': [1382], 'run-off': [1383], 'transcripts': [1384], 'synthesized': [1386, 1502], 'using': [1387], 'T7': [1388, 1504], 'polymerase.': [1390, 1506], 'HeLa': [1391, 1428, 1552, 1851, 2070, 3180, 3694], 'cell': [1392, 1429, 1553], 'extracts': [1394, 1705, 1853, 1937, 2098, 2306, 2405, 2471, 3696, 4346, 4378, 4385, 4425], 'prepared': [1396], '(16Mayeda': [1399, 1434], 'A.': [1400, 1435, 1522, 1638, 2477, 2951, 3073, 3079, 3120, 3268, 4676], 'Methods': [1403, 1438], '118:': [1407, 1442], '309-314PubMed': [1408, 1443], 'reactions': [1414, 1887, 1921, 3175], 'performed': [1416, 2303, 2327], 'total': [1419], 'volume': [1420, 1559, 1733], '25': [1422], 'μl,': [1423], '15': [1425, 3387], 'μl': [1426, 1550, 1562, 1726, 1736, 1782, 1944], 'extract': [1431, 1555, 1729, 3780, 3803], 'reaction': [1447, 1546, 1722], 'mixtures': [1448, 1723], 'incubated': [1450, 1543, 1764, 1840, 1917, 1934, 2403, 2695, 4301], '30': [1452, 1798], '°C': [1453, 1802, 1846], '1.5': [1455], 'RNAs': [1457, 1496, 1507, 2068, 2080], 'separated': [1459, 1603, 1872], '6%': [1462], 'polyacrylamide': [1463, 1605, 1874], 'gel': [1464, 4137], 'visualized': [1466], 'Kodak': [1469], '200R': [1470], 'Image': [1471], 'Station.': [1472], 'ratios': [1474], 'calculated': [1476], 'adjusting': [1477], 'relative': [1480, 2702], 'length': [1481], 'unspliced': [1486, 3193], 'products.': [1488, 3481], 'Chromatography': [1490], 'Assays': [1491], 'Nuclear': [1493], 'Extract': [1494], 'Depletion—Substrate': [1495], 'chromatography': [1499], '(RAC)': [1500], 'utilizing': [1503, 1708, 2304, 2331, 3709, 3762, 3790], 'covalently': [1509], 'linked': [1510], 'adipic': [1512], 'dihydrazide-agarose': [1514], 'beads': [1515, 1538, 1768, 1785, 1833, 1858, 2604, 2748], '(17Caputi': [1519], 'Mayeda': [1521, 3119], '18:': [1530], '4060-4067Crossref': [1531], '(226)': [1534], 'immobilized': [1540, 1596], 'mixture': [1547, 3866, 4394], '250': [1549, 1725, 1804, 1848], 'final': [1558, 1732, 4055], '400': [1561, 1735], '(20': [1563, 1737, 1809], 'HEPES-KOH,': [1565, 1739, 1811], 'pH': [1566, 1740, 1812], '7.9,': [1567, 1741, 1813], '5%': [1568, 1742, 1814], 'glycerol,': [1569, 1743, 1815], 'KCl,': [1572, 1746, 1818], '0.2': [1573, 1747, 1819], 'EDTA,': [1575, 1749, 1821], '0.5': [1576, 1750, 1822], 'dithiothreitol,': [1578, 1752, 1824], '4': [1579, 1582, 1753, 1756, 1801, 1825, 1828, 1845, 1943, 1946], 'ATP,': [1581, 1755, 1827], 'MgCl2).': [1584, 1830], 'Beads': [1585], 'washed,': [1588], 'specifically': [1592, 2075], 'bound': [1593, 2076, 2600], '2%': [1601, 1870], 'SDS,': [1602, 1871], 'SDS': [1606, 1875], 'gels,': [1607, 1876], 'electroblotted,': [1608, 1877], 'probed': [1610, 1879], 'antibodies': [1612], 'against': [1613], 'proteins:': [1616], 'A1,': [1620, 3012, 3747], 'K/J,': [1622, 2614], 'L': [1625], '(provided': [1626, 1635, 1652, 1662, 1677, 1688], 'Dr.': [1628, 1637, 1654, 1664, 1679, 1690], 'Dreyfuss,': [1630], 'University': [1631, 1683], 'Pennsylvania),': [1633], 'SF2/ASF': [1634], 'Krainer,': [1640], 'Cold': [1641, 1645], 'Spring': [1642, 1646], 'Harbor': [1643], 'Laboratories,': [1644], 'Harbor,': [1647], 'NY),': [1648], 'SC-35': [1649], '9G8': [1651], 'Stevenin,': [1656], 'INSERM,': [1657, 1668], 'Strasbourg,': [1658, 1669], 'France),': [1659, 1670], 'Fuchs,': [1667], 'H/H1,': [1672], 'PTB': [1676], 'L.': [1681, 2955, 3272, 4553], 'Black,': [1682], 'California),': [1685], 'Wilusz,': [1692], 'Colorado': [1693], 'State': [1694], 'University).': [1695], 'depleted': [1702, 3698, 3729, 3793, 3817, 3828, 3845, 3856, 3875, 4309, 4338, 4384, 4424], 'RAC': [1707, 2087, 2300, 2329, 2722, 3584, 3708], 'high': [1710, 3711], 'affinity': [1711, 3712], 'oligonucleotide': [1713], '(AGGGA)7': [1714, 3714], 'C(AGUC)4AGUCCU(CAGU)3': [1718], 'oligonucleotide.': [1720], 'MgCl2,': [1758], '5': [1759, 2445], 'creatine': [1761], 'phosphate)': [1762], 'RNA-bound': [1767], 'deplete': [1770], '>80%': [1771], 'GRSF-1.': [1779], 'Pull-down': [1780], 'Assays—100': [1781], 'Ni-NTA-agarose': [1784, 1857, 2417], 'incubate': [1787], 'variable': [1789], 'amounts': [1790, 2703, 4369], 'min': [1799], 'ml': [1805, 1849], 'incubation': [1807, 1855, 2727], 'buffer': [1808, 1969], 'Ni-NTA': [1832, 2603], 'unbound': [1837], 'h': [1843], 'buffer.': [1856], 'four': [1862], 'times,': [1863], 'specific': [1881, 3531], 'antibodies.': [1882], 'Spliceosome': [1883], 'Assembly': [1884], 'Reactions—Spliceosome': [1885], 'assembly': [1886, 1910, 1927, 3558, 3943], 'carried': [1889, 3177], '(18Das': [1894, 4139], 'Reed': [1896, 4141], '5:': [1902, 4147], '1504-1508Crossref': [1903, 4148], '(91)': [1906, 4151], 'For': [1909, 1926], 'E': [1913, 4156, 4173, 4312, 4453], 'complex,': [1914, 4019], 'pre-mRNAs': [1915, 1932], '20-μl': [1919], 'lacking': [1922], 'ATP': [1923], 'MgCl2.': [1925], 'complexes': [1931, 3975, 4224, 4333, 4406, 4447], 'under': [1938, 1982], 'conditions.': [1940], 'Where': [1941], 'indicated,': [1942], 'mg/ml': [1947], 'heparin': [1948], 'added': [1950], 'prior': [1951], 'loading': [1953], 'gels.': [1955, 1966], 'Reactions': [1956], '1.5%': [1960], 'low': [1961], 'melting': [1962], 'point': [1963], 'agarose': [1964, 2820, 4136], '(Invitrogen)': [1965], 'running': [1968], 'Tris': [1973], 'glycine.': [1977], 'Gels': [1978], 'dried': [1980], 'down': [1981, 2429], 'vacuum': [1983], 'room': [1985], 'temperature.': [1986], 'Sequence': [1987], 'showed': [1989, 4391], 'closely': [1999], 'related': [2000], 'identity': [2004], 'between': [2005, 2013, 2539, 2653, 4601], 'any': [2006], '44': [2014], '96%': [2016], '(Fig.': [2017, 2356, 2418, 2802, 2862, 2976, 3168, 3227, 3343, 3372, 3667, 3715, 3781, 3794, 3804, 4107, 4325, 4347, 4426], '1).': [2018, 2154], 'assemble': [2030, 2286, 3976, 4220], 'substrates': [2035, 2261, 3167, 3300, 3644, 4078], 'GGGA': [2039], '(19Caputi': [2040], '276:': [2048, 2964, 3281], '43850-43859Abstract': [2049], '(158)': [2057], 'This': [2060, 2086, 3884, 4008], 'result': [2061, 3770], 'achieved': [2063, 3862], 'incubating': [2065], 'short': [2066, 2187, 3595], 'extracts,': [2072, 2698, 3732], 'bait': [2079], 'than': [2082, 2186, 2626, 2794, 3718, 3920], 'analyzed.': [2085], 'allows': [2088], 'detection': [2091], 'RNA-protein': [2093, 2828], 'interactions': [2094, 2652, 2683], 'functional': [2096, 3537, 4005, 4022, 4097], 'mimic': [2100], 'environment.': [2104], 'Utilizing': [2105], 'technique': [2107], 'extended': [2109], 'previous': [2111, 2484], 'observations': [2112], 'define': [2114], 'precise': [2116], 'All': [2128, 3419, 3482], 'appear': [2136, 3338, 4640], 'share': [2138], 'similar': [2139], 'A,': [2149, 4206, 4329], 'U)': [2152], '(Table': [2153], 'C': [2155, 4056, 4209, 4238, 4332], 'residues': [2156, 2251], 'preceding': [2157], 'stretch': [2161, 2176], 'three': [2163, 2247, 4222], 'Gs': [2164, 2180], 'decreased': [2165], 'recruitment': [2167, 2686, 2811, 3587, 3660], 'Interestingly,': [2173], 'poly-G': [2175], 'constituted': [2177, 2262], 'recruits': [2181], 'less': [2184, 4230], 'efficiently': [2185, 3813, 4106, 4176], 'G': [2188], 'stretches': [2189], 'interrupted': [2231], 'U': [2235], 'residues.': [2236], 'Thus,': [2237, 2809, 3463, 4594], 'although': [2238, 3847], 'recognize': [2244], 'runs': [2245], 'more': [2249, 2783], 'Gs,': [2250], 'flank': [2253], 'modulate': [2257], 'binding.': [2259, 4195], 'Accordingly': [2260], 'exclusively': [2263], 'repeats': [2266], '(AGGGA7)': [2267], 'all': [2269], 'highest': [2279], 'efficiency.TABLE': [2280], '1hnRNP': [2281], 'Open': [2292], 'table': [2293], 'tab': [2297], 'Because': [2298, 2531, 2724, 3503, 4264], 'unclear': [2309], 'each': [2311, 2364], 'binds': [2313], 'directly': [2318], 'part': [2321], 'multiprotein': [2324, 2529], 'assay': [2330], 'single': [2333, 3833], 'proteins.': [2340, 4621], 'recruited': [2345, 3622], 'DGGGD-containing': [2348, 2761], 'but': [2350, 2448, 3413, 3627, 4182, 4339, 4410, 4448], '2A,': [2357], 'lanes': [2358, 2772, 2804, 3345, 3386, 3753, 3806, 4349, 4428], '2)': [2361], 'indicating': [2362], 'ability': [2372, 2494, 4535], 'sequence.': [2378, 3911], 'Next': [2379, 3673], 'examined': [2381], 'possibility': [2383, 2459], 'native': [2386, 4135], 'conditions': [2387, 2730], 'through': [2396], 'protein-protein': [2397, 2682], 'interaction.': [2398], 'end': [2401], 'coupled': [2415, 2433], '2B).': [2419], 'pulled': [2428], 'resin': [2432, 2452], '(lanes': [2437, 2444, 3633], '4)': [2440], '6)': [2447], '(lane': [2454], '7).': [2455], 'eliminate': [2457], 'interacting': [2464], 'RNA,': [2468], 'treated': [2474], 'RNase': [2476], 'agreement': [2482], 'work': [2485, 2533], 'showing': [2486], 'form': [2496, 2527], 'heterodimers': [2497], '(7Chou': [2498], 'suggest': [2518], 'recent': [2532, 4687], 'suggested': [2535], 'possible': [2537, 3551], '20Martinez-Contreras': [2568], 'Nasim': [2572], 'F.U.': [2573], 'Madden': [2574], 'Cordeau': [2576], '4:': [2583], 'e21Crossref': [2584], '(173)': [2587], 'fraction': [2591], 'his-tagged': [2595, 2709, 2740], 'presence': [2609, 4003, 4362], '(A1,': [2613], 'L,': [2615], 'PTB),': [2617], 'components.': [2622], 'No': [2623], 'associated': [2637], '(data': [2644], 'shown).': [2646, 3672], 'Nevertheless,': [2647], 'conceivable': [2650, 3515], 'components': [2662], 'occur': [2668], 'vivo': [2670], 'dynamic': [2673], 'pre-RNA-spliceosomal': [2674], 'extent': [2679], 'contribute': [2684], 'compared': [2700, 4072], 'pull-down': [2714], 'ones': [2718, 3922], 'assay.': [2723], 'washing': [2729], 'utilized': [2732, 2843, 3923, 4134], 'amount': [2738, 2754], 'roughly': [2750], 'equivalent': [2751], 'those': [2756], 'recovered': [2758], '(see': [2763], 'Fig.': [2764, 2995, 3384, 3610, 3751, 4170, 4197, 4262], '2B': [2765], 'blots': [2766], '1,': [2773, 2805], '3,': [2774, 2806, 2863, 2996], '5)': [2776], '∼6': [2781], 'times': [2782], 'recruiting': [2786], 'Ni-NTA-bound': [2800], '2B,': [2803], '5).': [2808], '(21)-bound': [2821], 'due': [2824, 3888, 4161, 4366], 'mainly': [2825], 'direct': [2827], 'interactions.': [2829], 'investigate': [2831, 3577, 4061], 'regulation,': [2841], 'substrate,': [2846], 'contains': [2848], 'B).': [2866, 2999], 'regulated': [2873, 4697], 'mapped': [2882], '(4Zahler': [2885, 3027], '15Amendt': [2909, 3051], '22Caputi': [2928], 'Freund': [2930], 'Kammler': [2932], 'Asang': [2934], 'C.': [2935, 2959, 3085, 3276], 'Schaal': [2936], 'Virol.': [2939, 3145], '78:': [2941], '6517-6526Crossref': [2942], '(77)': [2945], '23Jacquenet': [2948], 'Mereau': [2950, 3072, 3267], 'Bilodeau': [2952, 3269], 'P.S.': [2953, 3139, 3270], 'Damier': [2954, 3271], 'Branlant': [2958, 3084, 3275], '40464-40475Abstract': [2965, 3282], '(110)': [2973, 3290], '3B).': [2977], 'weakly': [2982], 'unless': [2984], 'ESS2,': [2986], 'located': [2987, 3235, 3452], '2,': [2991], '(pTat12-ESS2M,': [2994], 'Mutation': [3000, 3293], 'ESS': [3003], 'disrupting': [3007], 'which,': [3013], 'turn,': [3015], 'antagonizes': [3016], 'activity': [3018, 3879], 'nearby': [3024], 'ESE': [3025], '24Marchand': [3070], 'V.': [3071], 'Jacquenet': [3074], 'Thomas': [3076], 'Mougin': [3078], 'Gattoni': [3080], 'Stevenin': [3082], '323:': [3090], '629-652Crossref': [3091], '(83)': [3094], '25Tange': [3097], 'T.O.': [3098], 'Guth': [3101], 'Valcarcel': [3103], '20:': [3110], '5748-5758Crossref': [3111], '(134)': [3114], '26Zhu': [3117], '8:': [3126], '1351-1361Abstract': [3127], '(297)': [3135], '27Bilodeau': [3138], 'Domsic': [3140], 'J.K.': [3141], '73:': [3147], '9764-9772Crossref': [3148], 'pTat12-Ess2M': [3165], '3B,': [3169, 3373], 'S1-S8).': [3171], 'extracts;': [3182, 3897], 'efficiency': [3184, 3222, 3325, 3342, 3842, 3860, 4259], 'measured': [3186], 'ratio': [3189], 'versus': [3192], 'RNA.': [3194], 'general,': [3196], 'did': [3201, 3336, 3377, 3768], 'increase': [3203], 'wild-type': [3207], 'substrates,': [3208], 'exception': [3211], 'being': [3212], 'mutation': [3214, 3322, 3508, 3555, 3666, 4086], 'S8': [3217, 3232], 'G-run,': [3218, 3314, 3512], 'increased': [3220, 3840], '<0.05': [3224], '0.15': [3226], '3C,': [3228, 3344, 3385], 'lane': [3229, 3783, 3796], '9).': [3230], 'G-run': [3233, 3355, 3399, 3450, 3471, 3532, 3608, 3947, 4069, 4277], '(ESS2p),': [3242], 'appears': [3245], 'A1': [3252, 4705], 'decreases': [3257, 3323], 'accessibility': [3258], 'upstream': [3261], '(23Jacquenet': [3265], 'pTat12-ESS2M': [3299, 3488, 3692, 3786, 3955, 4217, 4298], 'putative': [3306], 'sites,': [3311], 'S3': [3313, 3321, 3354, 3398, 3449, 3470, 3511, 3554, 3607, 3665, 3946, 4068, 4276], '0.8': [3327], '0.2.': [3329], 'Mutations': [3330], 'alter': [3340], '11,': [3346], '12,': [3347], '17-19).': [3349], 'seems': [3356], 'crucial': [3357], 'activity,': [3360], 'repositioning': [3363], 'just': [3364], 'up-': [3365], 'downstream': [3367], 'original': [3370], 'S3-U': [3374], 'S3-D)': [3376], 'restore': [3379, 3932, 4402], '(pTatE12-S3-U': [3381], 'pTatE12-S3-D,': [3383], '16).': [3389], 'Given': [3390], 'could': [3400, 3885, 4401, 4695], 'well.': [3418, 4296], 'HIV-1-spliced': [3420], 'include': [3422], 'first': [3424, 3581, 4033], 'construct,': [3435], 'referred': [3436], 'major': [3440, 3458], 'site.': [3443, 3462], 'close': [3454, 4416], 'proximity': [3455], 'mechanism': [3465, 4616, 4701], 'via': [3468, 3533], 'potentially': [3473], 'most': [3478], 'potential': [3492], 'down-regulated': [3506], 'activate': [3523], 'imposing': [3534], 'spatial': [3535], 'constraints': [3538], 'cis-': [3543], 'trans-acting': [3545], 'elements.': [3547], 'Alternatively,': [3548], 'impairs': [3556], 'disrupts': [3563], 'secondary': [3566], 'further': [3576], 'possibilities,': [3579], 'confirmed': [3582], 'region': [3597], 'inhibited': [3604, 4317], 'mutation.': [3609], '4A': [3611, 3668], 'shows': [3612, 4214, 4229], 'wild': [3625], '2).': [3636, 3756], 'Analysis': [3637, 4129], 'indicates': [3645], 'that,': [3646], 'aside': [3647], 'no': [3655, 4237], 'show': [3658], 'altered': [3659], 'sought': [3675, 4283], '4B).': [3716], 'More': [3717], '80%': [3719], 'whereas': [3733, 3819, 4236, 4327], 'essential': [3737, 4120, 4279], 'factors,': [3739], 'retained': [3745], '(hnRNP': [3746], 'SF2/ASF,': [3748], 'SC35;': [3750], '4B,': [3752, 3782], 'Mock': [3757], 'depletions': [3758], 'done': [3760], 'substantial': [3773], '3).': [3784], 'mock': [3792, 3816, 3855, 4308, 4337, 4423], '4C,': [3795, 3805], '1)': [3797], 'family-depleted': [3801, 4306, 4345], '2-10).': [3807], 'extract,': [3818, 3846], 'product': [3822], 'barely': [3824], 'detectable': [3825], 'extract.': [3829, 3857], 'Addition': [3830], 'recombinants': [3834], 'level': [3852, 4415], 'Higher': [3858], 'adding': [3864], 'hnNRPs': [3868], 'extract;': [3876], 'nevertheless,': [3877], 'completely': [3882], 'restored.': [3883], 'lack': [3891], 'complemented': [3896], 'unfortunately,': [3898], 'unable': [3901], 'obtain': [3903], 'plasmid': [3906], 'full': [3909], 'It': [3912], 'plausible': [3915], 'isoforms,': [3918], 'recombination': [3926], 'assay,': [3927], 'fully': [3931], 'efficiency.': [3934], 'member': [3942], 'functions': [3960, 4501], 'activation': [3970], 'redundant.': [3973], 'Spliceosomal': [3974], 'stepwise': [3979], 'manner': [3980], 'vitro;': [3982], 'nonspecific': [3984], 'consists': [3988], 'members,': [3993], 'assembles': [3994], 'first,': [3995], 'independent': [4000], 'sites.': [4007, 4027], 'followed': [4010, 4040], 'ATP-independent': [4015, 4126, 4155, 4452], 'pre-spliceosomal': [4016, 4098, 4127], 'early': [4017], '(E)': [4018], 'enter': [4037], 'assembly,': [4039], 'B': [4043, 4233], 'catalytic': [4047], 'steps': [4048], 'take': [4051], 'place': [4052], 'after': [4053, 4244, 4379], 'assembled.': [4059], 'what': [4062], 'step': [4063], 'affected': [4065], 'mutation,': [4070, 4191], 'pTatE12-ESS2M,': [4079], 'pTat12-S3-ESS2M,': [4080], 'pTatE12-ESS2M-5′M.': [4082], 'pTatE12-ESS2M-5′M': [4083, 4185], 'carries': [4084], 'prevents': [4093, 4193], 'complexes,': [4099], 'therefore': [4101], '5A).': [4108], 'intact': [4110], 'U1': [4121, 4538, 4606], 'snRNP': [4122, 4539, 4607], 'component': [4123], 'electrophoresis': [4138], 'sensitivity': [4164], 'heparin;': [4166], '5B': [4171], 'assembled': [4177, 4334], 'pTatE12-ESS2M': [4179], 'pTat12-S3-ESS2M': [4181, 4227], 'snRNPU1': [4194], '5C,': [4198], 'B,': [4207, 4330, 4409], 'time': [4212], 'course': [4213], 'efficiently.': [4225], 'clearly': [4242], 'detected': [4243], 'longer': [4246, 4693], 'exposure.': [4247], 'decrease': [4249, 4256], 'correlates': [4253], 'seen': [4260], '3C.': [4263], 'extracts.': [4311], '5D),': [4326], '5E,': [4348, 4427], '1-8).': [4350], 'After': [4351], '40-min': [4353], 'incubation,': [4354], 'visible,': [4359], 'might': [4363], 'residual': [4368], 'left': [4374], 'depletion.': [4380], 'Reconstitution': [4381], 'C,': [4412], '9-12).': [4429], 'results': [4431], 'studied': [4459], 'five': [4464], 'Previous': [4474], 'research': [4475], 'involvement': [4479], 'utilization': [4489], 'silencers,': [4495], 'models': [4498], 'proposed.': [4507], 'NF-1': [4519], 'TSHβ': [4523], 'restricting': [4533], '(28Buratti': [4547], 'E.': [4548], 'De': [4551], 'Conti': [4552], 'Ayala': [4558], 'Y.M.': [4559], '32:': [4566], '4224-4236Crossref': [4567], '(69)': [4570], 'However,': [4573], 'found': [4583, 4629], 'constitutively': [4591], 'exons.': [4593], 'unlikely': [4597], 'interplay': [4600], 'sole': [4615], 'Genomic': [4622], 'studies': [4623], 'preferentially': [4630], 'immediately': [4634], 'flanking': [4635], 'facilitate': [4642], '(29McCullough': [4647], 'A.J.': [4648], 'Berget': [4649], 'S.M.': [4650], '1997;': [4654], '17:': [4655], '4562-4571Crossref': [4656], '(185)': [4659], '30Yeo': [4662], 'Hoon': [4664], 'Venkatesh': [4666], 'Proc.': [4670], 'Natl.': [4671], 'Acad.': [4672], 'U.': [4674], '101:': [4678], '15700-15705Crossref': [4679], '(184)': [4682], 'Accordingly,': [4685], 'report': [4688], 'proposed': [4689], 'looping-out': [4700], 'H/F': [4708], 'proximal': [4714]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2016348135', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-09T05:20:15.764405', 'created_date': '2016-06-24'}