Title: Preparation of Heterogeneous Nuclear Ribonucleoprotein Complexes
Abstract: Proper formation of different types of ribonucleoprotein (RNP)-RNA complexes is critical for the correct expression of genetic information at the posttranscriptional level. In the nucleus, RNA polymerase II transcripts bind to an abundant class of nuclear pre-mRNA/mRNA-binding proteins, the heterogeneous nuclear ribonucleoproteins (hnRNPs), to form hnRNP complexes (,). The molecular architecture of these complexes must be exceedingly dynamic because each step in the pre-mRNA processing pathway alters the structure of the underlying RNA substrate. Therefore, hnRNP complexes within the cell, although probably unique for each transcript, are not uniform structures, such as a ribosomal subunit or a particular small nuclear ribonucleoprotein particle (snRNP), but are composed of a heterogeneous mixture of protein-RNA structures.
Publication Year: 2003
Publication Date: 2003-11-15
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 6
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