NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

Name: Work Video:
Duration: 3 min 30 s
Guangjie Cheng; J. David Lambeth
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564, 1024, 1680, 5064, 5491], 'oxidase,': [38, 254, 1681], 'its': [40, 146, 256, 362, 1304, 1628, 1915, 2166, 2170, 2177, 5180, 5770], 'translocation': [41, 257], 'to': [42, 96, 121, 160, 213, 258, 312, 337, 376, 429, 440, 653, 971, 996, 1392, 1598, 1643, 1660, 1800, 1819, 1957, 2039, 2155, 2219, 2336, 2353, 2641, 2681, 2717, 2801, 2842, 2870, 2990, 3035, 3064, 3112, 3241, 3435, 3761, 3840, 3852, 4029, 4089, 4114, 4139, 4150, 4158, 4221, 4239, 4241, 4247, 4263, 4267, 4315, 4364, 4406, 4427, 4437, 4441, 4459, 4466, 4493, 4505, 4539, 4556, 4570, 4653, 4658, 4826, 4855, 4862, 4864, 4927, 4996, 5059, 5117, 5132, 5156, 5184, 5213, 5281, 5332, 5361, 5378, 5400, 5404, 5458, 5470, 5556, 5559, 5568, 5581, 5626], 'membrane': [44, 124, 214, 260, 340, 430, 556, 1664, 2196, 3722, 3767, 3847, 4016, 4024, 4439, 4444, 4469, 4541, 4561, 4591, 4829, 5223, 5335, 5407], 'is': [45, 111, 127, 143, 202, 261, 327, 343, 359, 418, 568, 1027, 1030, 1129, 1593, 1618, 1798, 1824, 1838, 2473, 2486, 3361, 3424, 3442, 3718, 4047, 4155, 4184, 4226, 4339, 4349, 4404, 4425, 4457, 4943, 4951, 5045, 5052, 5176, 5201, 5233, 5495, 5551, 5587, 5806, 5815, 5833], 'triggered': [46, 262, 1130], 'upon': [47, 263, 1032, 1646, 1809], 'cell': [48, 92, 264, 308, 687, 1033, 1647, 2051, 4498, 5123, 5766, 5820, 5834], 'by': [50, 145, 206, 266, 361, 422, 570, 574, 986, 1035, 1131, 1620, 1708, 1858, 2317, 2344, 2368, 2404, 2421, 2439, 2446, 2734, 3224, 3318, 3328, 3393, 4355, 4837, 4953, 5478, 5554, 5830, 5955, 5961, 5976], 'hyperphosphorylation,': [51, 267], 'which': [52, 110, 268, 326, 987, 1111, 1297, 2625, 3423, 3844, 4084, 4230, 4477, 4483, 5051, 5141, 5208, 5868, 5977], 'relieves': [53, 269], 'autoinhibition': [54, 270], 'SH3': [56, 272, 1307, 1623, 1640, 1917, 4401, 4487, 5267, 5355, 5464, 5547], 'PX': [58, 147, 167, 211, 274, 363, 383, 427, 1462, 1616, 1953, 2161, 2188, 2814, 4073, 4075, 4094, 4253, 4256, 4357, 4385, 4462, 4480, 4533, 4596, 4643, 4715, 4860, 4920, 4979, 5257, 5573], 'domains.': [59, 275], 'lacks': [61, 277, 2138, 4478], 'autoinhibitory': [63, 279, 1295, 1634, 1655, 1683, 2140, 4833], 'region': [64, 280, 2783, 4397, 4402, 5268], 'phosphorylation': [66, 282, 1186, 1302, 2143], 'sites': [67, 283, 2144, 4720, 5114], 'that': [68, 284, 558, 610, 667, 1608, 1812, 1835, 1853, 1903, 1912, 1926, 2145, 3410, 3441, 3579, 3667, 3669, 3729, 3783, 4052, 4161, 4232, 4337, 4403, 4414, 4454, 4489, 4506, 4571, 4583, 4651, 4948, 4958, 4987, 5061, 5115, 5119, 5151, 5191, 5210, 5269, 5324, 5435, 5450, 5538, 5613, 5769], 'present': [70, 286, 1041, 1962, 2147, 2151, 2478, 2493, 2761, 3391, 3443, 4163, 5143, 5206, 5535], 'p47phox.': [72, 288, 1820, 2149], 'Co-transfection': [73, 289], 'Nox1,': [75, 291, 840, 2540, 3016, 3333, 3401, 4327, 5328], 'NOXO1,': [76, 292, 1913, 2164, 2630, 3017, 3334], 'reconstitutes': [79, 295], 'ROS': [80, 296, 963, 991, 1688, 1856, 3414, 3531, 3564, 3877, 4317, 4346, 5286, 5381, 5636, 5799, 5875, 5980, 5990], '(reactive': [81, 297], 'oxygen': [82, 298, 591, 599, 1003, 3233, 4961], 'species)': [83, 299], 'generation': [84, 300, 964, 1689, 1857, 3415, 3532, 3565, 4347, 4962, 5287, 5637], 'HEK293': [86, 187, 302, 403, 3330, 3693, 3830, 3935, 4020, 4526, 5540, 5787], 'cells': [87, 118, 303, 334, 1100, 1596, 2210, 2230, 2382, 3028, 3041, 3062, 3093, 3148, 3167, 3194, 3270, 3331, 3344, 3569, 3694, 3799, 3936, 4046, 4166, 4527, 5150, 5190, 5642, 5973], 'absence': [90, 306, 1300, 1692, 2049, 2224, 4059, 5600], 'stimulation.': [93, 309], 'binds': [95, 311, 1303, 5128, 5212, 5468], 'phosphatidylinositol': [98, 314, 1472, 4140, 4142, 4145, 4151, 4242, 4264, 4271, 4620, 4722, 4932], '(PtdIns)': [99, 315], 'lipids': [100, 316, 1631, 1665, 2206, 4865, 4998, 5118], 'PtdIns': [101, 103, 106, 317, 319, 322, 4939, 5136, 5139], '3,5-P2,': [102, 318], '5-P,': [104, 320, 5140], '4-P.': [107, 323], 'Unlike': [108, 324], 'p47phox,': [109, 325, 1075, 1626, 1653, 1948, 2040, 4612, 5174, 5437, 5867], 'located': [112, 328, 3763], 'cytosol': [115, 331, 1044], 'resting': [117, 137, 333, 353, 1099, 2209, 4165, 5216], 'translocates': [120, 336], 'plasma': [123, 339, 3721, 3766, 3846, 3952, 4015, 4023, 4438, 4560, 4590, 5147, 5187, 5220, 5406], 'where': [125, 341, 5231], 'gp91phox': [126, 342, 1397, 2358, 2598, 3440, 4033], 'located,': [128, 344, 5588], 'co-localizes': [130, 346], 'with': [131, 347, 438, 549, 844, 1038, 1105, 1126, 1386, 1396, 1464, 1630, 1662, 1667, 1923, 2205, 2239, 2322, 2650, 2677, 2727, 2806, 2857, 2885, 2921, 2950, 2961, 2968, 2983, 3050, 3072, 3105, 3138, 3155, 3236, 3274, 3278, 3332, 3347, 3536, 3698, 3734, 3800, 4049, 4107, 4147, 4236, 4321, 4371, 4546, 4589, 4989, 5129, 5186, 5196, 5246, 5252, 5273, 5346, 5364, 5384, 5402, 5439, 5452, 5544], 'Nox1': [132, 193, 348, 409, 1859, 1933, 2046, 2175, 2221, 2323, 2384, 2719, 2736, 2785, 3086, 3141, 3339, 3419, 3537, 3571, 3672, 3682, 3717, 3927, 3945, 5232, 5253, 5501, 5586, 5597, 5614, 5630, 5763, 5891, 5950], 'membranes': [135, 351, 2965, 3850, 5148, 5188, 5214, 5230, 5584], 'cells.': [138, 354, 2392, 3831, 4021, 4595, 5605, 5621], 'This': [139, 355, 1669, 1960, 2433, 2674, 3432, 4225, 5199, 5222], 'localization': [140, 177, 356, 393, 2180, 2197, 2707, 4017, 4542], 'dictated': [144, 360], 'domain,': [148, 364, 1296, 1961, 2334, 4254, 4463], 'since': [149, 365, 3372], 'this': [150, 201, 366, 417, 2203, 3558, 3585, 4233, 4547, 4848, 5579], 'domain': [151, 168, 212, 367, 384, 428, 1460, 1617, 1624, 1635, 1954, 2141, 2162, 2189, 2204, 4095, 4257, 4386, 4481, 4534, 4603, 4644, 4661, 4834, 4854, 4861, 4921, 4980, 5258, 5342, 5465, 5481, 5574], 'but': [152, 368, 2385, 2394, 3420, 3969, 4482], 'not': [153, 369, 669, 2395, 3421, 3732, 3794, 3812, 3887, 4529, 5153, 5193, 5359, 5552, 5609, 5881], 'remainder': [155, 371, 4390], 'molecule': [158, 374, 4393], 'localizes': [159, 375, 4419, 4430, 4465, 4495, 5225], 'membranes.': [161, 377, 5221], 'A': [162, 378, 432, 4305, 5235], 'point': [163, 379, 2665, 5567, 5625], 'mutation': [164, 380, 2666, 2752, 3433, 3438, 4234, 4580, 5236, 5337, 5371, 5391], 'holo-NOXO1': [170, 386], 'decreases': [171, 387, 5373], 'lipid': [172, 388, 1458, 2167, 4223, 4585, 4929, 4946, 4984, 5240, 5247, 5340, 5368, 5394, 5453], 'resulting': [174, 390], 'cytosolic': [176, 392, 1103, 3741, 4448], 'also': [179, 395, 1455, 1849, 3915, 4452, 4587, 5053, 5372], 'inhibits': [180, 396], 'NOXO1-activation': [181, 397], 'Nox1.': [183, 399, 5564], 'Thus,': [184, 400, 1645, 3574, 4006, 4531, 4577, 5109, 5172, 5353, 5949], 'transfected': [186, 402, 3025, 3071, 3535, 3933, 4019], 'cells,': [188, 404, 2399, 3551, 3996, 5217, 5541, 5788, 5804], 'activate': [192, 408, 2220, 4959, 5062], 'without': [194, 410], 'need': [196, 412], 'for': [197, 413, 1449, 1466, 1676, 1908, 1932, 1937, 1943, 2214, 2464, 2597, 2623, 2851, 3109, 3189, 3217, 3260, 3309, 3561, 3926, 4721, 4938, 5284, 5436, 5487, 5497, 5592, 5888], 'agonist': [198, 414, 4063, 5602], 'activation,': [199, 415, 1648], 'mediated': [203, 419], 'part': [205, 421, 5591], 'lipids.': [215, 431, 4244], 'family': [433], 'reactive': [435, 590, 1002, 4960], 'oxygen-generating': [436], 'enzymes': [437, 662, 967, 989], 'homology': [439, 601, 1006], 'gp91phox,': [441, 1938], 'catalytic': [443], 'subunit': [444, 5580], 'NADPH-oxidase': [448, 5065], 'was': [449, 2153, 2315, 2409, 2435, 2544, 2599, 2610, 2626, 2657, 2675, 2693, 2732, 2849, 2891, 2995, 3133, 3234, 3294, 3305, 3326, 3340, 3375, 3382, 3406, 3572, 3822, 3873, 3884, 3912, 3961, 3972, 3991, 3999, 4087, 4122], 'recently': [450, 1704, 5278, 5870], 'described': [451, 2545, 4599], '(1Suh': [452, 692, 2547, 3500, 5643], 'Y.-A.': [453, 693, 2548, 3501, 5644], 'Arnold': [454, 483, 694, 770, 801, 861, 2549, 3502, 5645], 'R.S.': [455, 484, 695, 720, 771, 802, 862, 2550, 3503, 5646], 'Lassegue': [456, 696, 901, 932, 2551, 3504, 5647], 'B.': [457, 697, 759, 800, 860, 902, 933, 1141, 1168, 1712, 2058, 2552, 3505, 3588, 5648, 5671], 'Shi': [458, 698, 721, 2553, 3506, 5649], 'J.': [459, 641, 699, 722, 820, 880, 1050, 1137, 1142, 1157, 1159, 1162, 1169, 1191, 1201, 1204, 1225, 1242, 1317, 1406, 1556, 1575, 1719, 1751, 1772, 1775, 1886, 1979, 1996, 2006, 2065, 2097, 2118, 2121, 2515, 2554, 3484, 3507, 3595, 3627, 3648, 3651, 4787, 4900, 4910, 4968, 5007, 5017, 5074, 5304, 5418, 5518, 5650, 5718, 5739, 5742, 5909, 5930, 5933], 'Xu': [460, 507, 700, 2555, 2578, 3508, 5651], 'X.': [461, 508, 701, 1570, 2556, 2579, 3509, 4782, 5413, 5652], 'Sorescu': [462, 702, 907, 934, 2557, 3510, 5653, 5672], 'D.': [463, 703, 898, 900, 935, 1366, 1485, 1509, 1992, 2516, 2558, 3468, 3511, 4675, 4702, 4735, 4877, 4896, 5003, 5654, 5673], 'Chung': [464, 704, 2559, 3512, 5655], 'A.B.': [465, 705, 806, 866, 2560, 3513, 5656], 'Griendling': [466, 706, 919, 948, 2561, 3514, 5657, 5686], 'K.K.': [467, 707, 920, 949, 2562, 3515, 5658, 5687], 'Lambeth': [468, 512, 708, 735, 772, 815, 875, 913, 946, 2563, 2583, 3516, 5659, 5684], 'J.D.': [469, 480, 513, 525, 709, 736, 773, 816, 876, 914, 916, 947, 1049, 2564, 2584, 3517, 5660, 5685], 'Nature.': [470, 644, 710, 2565, 3518, 5661], '1999;': [471, 711, 1320, 2566, 3519, 5662], '401:': [472, 712, 2567, 3520, 5663], '79-82Crossref': [473, 713, 2568, 3521, 5664], 'PubMed': [474, 498, 519, 532, 619, 648, 714, 747, 784, 825, 885, 925, 957, 1068, 1151, 1180, 1215, 1229, 1255, 1284, 1328, 1350, 1379, 1412, 1439, 1495, 1516, 1543, 1562, 1586, 1730, 1762, 1786, 1897, 1985, 2010, 2032, 2076, 2108, 2132, 2569, 2590, 3254, 3462, 3493, 3522, 3606, 3638, 3662, 4175, 4216, 4300, 4637, 4688, 4709, 4745, 4772, 4798, 4813, 4890, 4914, 4972, 5021, 5038, 5083, 5104, 5167, 5315, 5429, 5529, 5665, 5693, 5729, 5753, 5920, 5944], 'Scopus': [475, 499, 520, 533, 649, 715, 748, 785, 826, 886, 926, 958, 1069, 1181, 1216, 1230, 1285, 1329, 1351, 1380, 1413, 1440, 1496, 1517, 1544, 1587, 1731, 1763, 1787, 1898, 2011, 2033, 2077, 2109, 2133, 2570, 2591, 3255, 3463, 3523, 3607, 3639, 3663, 4176, 4217, 4301, 4638, 4689, 4710, 4746, 4773, 4799, 4814, 4891, 4915, 4973, 5022, 5039, 5105, 5168, 5316, 5430, 5530, 5666, 5694, 5730, 5754, 5921, 5945], '(1280)': [476, 716, 2571, 3524, 5667], 'Google': [477, 501, 522, 535, 620, 651, 717, 750, 787, 828, 888, 928, 960, 1071, 1152, 1183, 1218, 1232, 1256, 1287, 1331, 1353, 1382, 1415, 1442, 1498, 1519, 1546, 1563, 1589, 1733, 1765, 1789, 1900, 1986, 2013, 2035, 2079, 2111, 2135, 2572, 2593, 3257, 3465, 3494, 3525, 3609, 3641, 3665, 4178, 4219, 4303, 4640, 4691, 4712, 4748, 4775, 4801, 4816, 4893, 4917, 4975, 5024, 5041, 5084, 5107, 5170, 5318, 5432, 5532, 5668, 5696, 5732, 5756, 5923, 5947], 'Scholar,': [478, 502, 523, 718, 751, 788, 929, 1153, 1219, 1332, 1354, 1416, 1499, 1520, 1547, 1564, 1734, 1766, 2014, 2080, 2112, 2573, 3466, 3610, 3642, 4692, 4749, 4776, 4802, 4894, 5025, 5085, 5669, 5733, 5924], '2Lambeth': [479], 'Cheng': [481, 2513], 'G.': [482, 504, 635, 2575, 5096], 'Edens': [485], 'W.E.': [486], 'Trends': [487], 'Biochem.': [488, 1051, 1224, 1488, 2025, 3247, 4171, 4738, 4967, 5097, 5163], 'Sci.': [489, 740, 777, 1064, 1277, 1372, 1432, 1558, 1981, 4633, 4681, 4883], '2000;': [490, 1054], '25:': [491], '459-461Abstract': [492], 'Full': [493, 495, 1148, 1175, 1177, 1210, 1212, 1323, 1325, 1345, 1347, 1581, 1583, 1725, 1727, 1757, 1759, 1781, 1783, 1892, 1894, 2071, 2073, 2103, 2105, 2127, 2129, 3459, 3601, 3603, 3633, 3635, 3657, 3659, 4793, 4795, 5033, 5035, 5080, 5310, 5312, 5424, 5426, 5524, 5526, 5724, 5726, 5748, 5750, 5915, 5917, 5939, 5941], 'Text': [494, 496, 1149, 1176, 1178, 1211, 1213, 1324, 1326, 1346, 1348, 1582, 1584, 1726, 1728, 1758, 1760, 1782, 1784, 1893, 1895, 2072, 2074, 2104, 2106, 2128, 2130, 3460, 3602, 3604, 3634, 3636, 3658, 3660, 4794, 4796, 5034, 5036, 5081, 5311, 5313, 5425, 5427, 5525, 5527, 5725, 5727, 5749, 5751, 5916, 5918, 5940, 5942], 'PDF': [497, 1150, 1179, 1214, 1327, 1349, 1585, 1729, 1761, 1785, 1896, 2075, 2107, 2131, 3461, 3605, 3637, 3661, 4797, 5037, 5082, 5314, 5428, 5528, 5728, 5752, 5919, 5943], '(331)': [500], '3Cheng': [503, 2574], 'Cao': [505, 2576], 'Z.': [506, 792, 852, 2577], 'van': [509, 2580], 'Meir': [510, 2581], 'E.G.': [511, 2582], 'Gene': [514, 2585], '(Amst.).': [515, 2586], '2001;': [516, 744, 1492, 1513, 1540, 2029, 2587, 4213, 4297, 4706, 4742, 4769, 4810, 5690], '269:': [517, 1146, 2588], '131-140Crossref': [518, 2589], '(705)': [521, 2592], '4Lambeth': [524], 'Curr.': [526], 'Opin.': [527], 'Hematol.': [528], '2002;': [529, 645, 781, 922, 954, 1065, 1559, 1578, 1982, 2007, 4790, 4911, 5018, 5030, 5421], '9:': [530], '11-17Crossref': [531], '(232)': [534], 'Scholar).': [536, 829, 961, 1072, 1288, 1590, 2036, 2136, 2594, 3495, 4179, 4304, 4641, 4713, 4817, 4918, 4976, 5042, 5108, 5171, 5319, 5697, 5948], 'Gp91phox': [537], 'contains': [538, 1456, 1950, 4398, 4647, 4981, 5264], 'FAD,': [539], 'two': [540, 2886, 3785], 'hemes,': [541], 'NADPH': [544, 3429], 'site': [546, 1448, 1942, 2758, 2770, 4986, 5242, 5370, 5396], 'together': [548], 'p22phox': [550, 1907, 2711, 2721, 3838, 4518, 4856, 5276, 5471, 5494], 'constitutes': [551, 559], 'flavocytochrome': [552, 1025, 1127], 'b558,': [553], 'intrinsic': [555], 'complex': [557, 1104, 1922], 'core': [561], 'oxidase.': [565, 5492], 'The': [566, 1092, 1388, 1591, 1612, 1795, 1821, 2150, 2200, 2495, 2536, 2595, 2690, 2874, 3749, 3788, 3930, 4022, 4134, 4395, 4642, 4818, 4919, 4977, 5366, 5462], 'oxidase': [567, 1119], 'activated': [569, 1031, 1594, 4037, 4952, 5054, 5618], 'immune': [571, 1602, 1694], 'mediators': [572, 1695], 'bacterial': [575, 1599], 'products': [576, 1470, 1600, 4930], 'participates': [578, 1968, 2042], 'first': [581, 2919], 'line': [582], 'host': [584, 676], 'defense,': [585, 677], 'generating': [586], 'large': [587, 3726], 'amounts': [588], 'species': [592, 1004], '(ROS)': [593], '1The': [594], 'abbreviations': [595], 'used': [596, 2487, 2676], 'are:': [597], 'ROSreactive': [598], 'speciesSH3Src': [600], '3BSAbovine': [602], 'serum': [603, 1009], 'albuminGFPgreen': [604], 'fluorescent': [605, 1012, 2653, 3082, 3700, 3706, 3751, 3981, 4010, 4374], 'proteinEGFPenhanced': [606], 'GFPGSTglutathione': [607], 'S-transferasePBSphosphate-buffered': [608], 'saline.': [609, 1019], 'function': [611, 1113, 1817, 2158, 4717, 5499], 'directly': [612], '(5Babior': [613], 'B.M.': [614, 1265, 1273], 'Blood.': [615, 1251, 3489], '1984;': [616], '64:': [617], '959-966Crossref': [618], 'Scholar)': [621, 652, 889, 1184, 1233, 1257, 1790, 1901, 1987, 3666, 4220, 5757], 'indirectly': [623], '(6Reeves': [624], 'E.P.': [625, 2018], 'Lu': [626], 'H.': [627, 1312, 1316, 1360, 1368, 1479, 1487, 1501, 1507, 1524, 1528, 1748, 1750, 1883, 1885, 2022, 2094, 2096, 3488, 3624, 3626, 4197, 4201, 4281, 4285, 4669, 4677, 4694, 4700, 4729, 4737, 4753, 4757, 4871, 4879, 5301, 5303, 5515, 5517, 5715, 5717, 5906, 5908], 'Jacobs': [628], 'H.L.': [629], 'Messina': [630], 'C.G.': [631, 1403], 'Bolsover': [632], 'S.': [633, 732, 742, 769, 779, 891, 1221, 1279, 1374, 1434, 1551, 1974, 3553, 4683, 4885], 'Gabella': [634], 'Potma': [636], 'E.O.': [637], 'Warley': [638], 'A.': [639, 743, 780, 1263, 1280, 1375, 1435, 3478, 3480, 4684, 4886, 4964], 'Roes': [640], 'Segal': [642, 2023, 3477], 'A.W.': [643, 2024, 3452], '416:': [646], '291-297Crossref': [647], '(903)': [650], 'kill': [654], 'invading': [656], 'microbe.': [657], 'In': [658, 830, 1020, 1865, 2037, 3337, 3384, 3496, 3814, 3859, 3954, 4245, 5125, 5698, 5779], 'contrast,': [659, 5126], 'Nox': [661, 837, 966, 988], 'expressed': [664, 2635, 3691, 3719, 3950, 3962, 3973, 4100], 'tissues': [666], 'typically': [670], 'thought': [671], 'participating': [674], 'have': [681, 1703, 1815, 3540, 3895, 5152, 5192, 5758, 5880], 'been': [682, 842, 1705, 5154, 5194, 5279, 5871], 'proposed': [683], 'including': [684, 847, 1237, 1791, 2165, 4611, 5218], 'regulation': [685, 5892], 'growth,': [688], 'apoptosis,': [689], 'angiogenesis': [691], '7Arnold': [719], 'Murad': [723], 'E.': [724, 3486, 4102], 'Whalen': [725], 'A.M.': [726], 'Sun': [727], 'C.Q.': [728], 'Polavarapu': [729], 'R.': [730, 757, 796, 856, 1362, 1477, 1736, 1871, 2082, 3476, 3612, 4671, 4727, 4873, 5289, 5503, 5703, 5894], 'Parthasarathy': [731], 'Petros': [733, 754], 'J.A.': [734, 755, 1244], 'Proc.': [737, 774, 1274, 1369, 1429, 4678, 4880], 'Natl.': [738, 775, 1275, 1370, 1430, 4679, 4881], 'Acad.': [739, 776, 1276, 1371, 1431, 4680, 4882], 'U.': [741, 778, 1278, 1373, 1433, 4682, 4884], '98:': [745], '5550-5555Crossref': [746], '(423)': [749], '8Arbiser': [752], 'J.L.': [753], 'Klafter': [756], 'Govindajaran': [758], 'McLaughlin': [760], 'E.R.': [761], 'Brown': [762, 1531, 4204, 4288, 4760], 'L.F.': [763], 'Cohen': [764], 'C.': [765, 3474], 'Moses': [766], 'M.': [767, 1195, 1197, 1203, 1742, 1744, 1768, 1877, 1879, 2088, 2090, 2114, 3470, 3618, 3620, 3644, 4806, 5089, 5295, 5297, 5509, 5511, 5679, 5709, 5711, 5735, 5900, 5902, 5926], 'Kilroy': [768], '99:': [782], '715-720Crossref': [783], '(403)': [786], '9Brar': [789], 'S.S.': [790, 850], 'Corbin': [791, 851], 'Kennedy': [793, 853], 'T.P.': [794, 808, 854, 868], 'Hemendinger': [795, 855], 'Thornton': [797, 857], 'L.': [798, 858, 910, 939, 1139, 1164], 'Bommarius': [799, 859], 'Whorton': [803, 863], 'A.R.': [804, 864], 'Sturrock': [805, 865], 'Huecksteadt': [807, 867], 'Quinn': [809, 869, 911, 944], 'M.T.': [810, 870, 912, 945], 'Krenitsky': [811, 871], 'K.': [812, 872, 906, 931, 1336, 1340, 1716, 1740, 1770, 1875, 2062, 2086, 2116, 3482, 3592, 3616, 3646, 5293, 5507, 5675, 5707, 5737, 5898, 5928], 'Ardie': [813, 873], 'K.G.': [814, 874], 'Hoidal': [817, 877], 'J.R.': [818, 878], 'Am.': [819, 879], 'Physiol.': [821, 881], '2003;': [822, 882, 1281, 1342, 1376, 1722, 1754, 1778, 1889, 2068, 2100, 2124, 3598, 3630, 3654, 4685, 4887, 5307, 5521, 5721, 5745, 5912, 5936], '285:': [823, 883], 'C353-C369Crossref': [824, 884], '(225)': [827, 887], 'addition,': [831, 1866, 3955, 5699], 'inappropriate': [832], 'or': [834, 1117, 1601, 1696, 2720, 2820, 3013, 3021, 3074, 3087, 3350, 3354, 3357, 3403, 4092, 4324, 4332, 4388, 4503, 5850], 'expression': [835, 2848], 'enzymes,': [838], 'particularly': [839], 'has': [841, 5277, 5869], 'associated': [843], 'neoplastic': [845], 'growth': [846], 'cancer': [848], '(9Brar': [849], '2R.': [890, 3552], 'Arnold,': [892, 3554], 'unpublished': [893, 2483, 3555, 5784], 'data.': [894, 2484, 3556, 5785], 'atherosclerosis': [896], '(10Sorescu': [897], 'Weiss': [899], 'Clempus': [903], 'R.E.': [904], 'Szocs': [905, 5674], 'G.P.': [908], 'Valppu': [909, 938], 'Vega': [915], 'Taylor': [917], 'W.R.': [918], 'Circulation.': [921], '105:': [923], '1429-1435Crossref': [924], '(776)': [927], '11Szocs': [930], 'Hilenski': [936], 'L.L.': [937], 'Couse': [940], 'T.L.': [941, 1774, 2120, 3650, 5741, 5932], 'Wilcox': [942], 'J.N.': [943], 'Arterioscler.': [950], 'Thromb.': [951], 'Vasc.': [952], 'Biol.': [953, 1053, 1143, 1170, 1205, 1318, 1512, 1539, 1576, 1720, 1752, 1776, 1887, 2066, 2098, 2122, 3596, 3628, 3652, 4212, 4296, 4705, 4768, 4788, 5075, 5305, 5419, 5519, 5719, 5743, 5910, 5934], '22:': [955], '21-27Crossref': [956], '(402)': [959], 'Similarly,': [962, 5275], 'through': [965], 'may': [968, 993, 1112, 3559, 3744, 3894, 5445, 5482, 5615, 5772, 5838], 'be': [969, 994, 2506, 3762, 5282, 5616, 5773, 5952, 5983, 5994], 'relevant': [970, 995], 'insulin': [972], 'mechanisms': [973, 985, 5957, 5964, 5969], 'hence': [975], 'diabetes.': [976], '3B.': [977], 'Goldstein,': [978], 'personal': [979], 'communication.': [980, 2511], 'Therefore,': [981], 'characterization': [982], 'regulate': [990], 'production': [992], 'pathophysiology': [998], 'these': [1000, 2773, 3550, 3568, 3575, 3770, 3791, 4042], 'diseases.': [1001], 'Src': [1005], '3': [1007, 2852, 3190, 4436], 'bovine': [1008, 2242], 'albumin': [1010], 'green': [1011, 3699], 'enhanced': [1014], 'GFP': [1015], 'glutathione': [1016, 4108], 'S-transferase': [1017], 'phosphate-buffered': [1018], 'naive': [1021], 'neutrophils,': [1022], 'b558': [1026, 1128], 'dormant': [1028], 'stimulation': [1034, 5603], 'assembly': [1037, 1677, 5488], 'subunits': [1040], '(reviewed': [1045], 'Refs.': [1047, 2056], '12Lambeth': [1048], 'Mol.': [1052, 1062, 3453], '33:': [1055], '427-439Google': [1056], 'Scholar': [1057], '13Vignais': [1059], 'P.V.': [1060], 'Cell': [1061, 1538, 1557, 1980, 4211, 4295, 4767], 'Life': [1063], '59:': [1066], '1428-1459Crossref': [1067], '(631)': [1070], 'These': [1073, 1847, 5565, 5606], 'include': [1074, 3845], 'a': [1076, 1080, 1102, 1106, 1394, 1445, 1457, 1816, 1921, 1940, 1964, 2212, 2362, 2401, 2509, 2660, 2664, 2678, 2687, 2755, 2768, 2789, 3120, 3264, 3289, 3297, 3704, 3819, 3956, 4014, 4090, 4268, 4399, 4500, 4564, 4601, 4648, 4944, 4982, 4993, 5265, 5795, 5807, 5885, 5974], '47-kDa': [1077], 'protein,': [1078, 1082, 1109, 4521], 'p67phox,': [1079], '67-kDa': [1081], 'Rac': [1084, 5849], '(Rac2': [1085], 'possibly': [1087], 'Rac1,': [1088], 'closely': [1089], 'related': [1090], 'isoforms).': [1091], 'p67phox': [1096, 1125, 1188, 1702, 1822, 1837], 'exist': [1097], 'third': [1107, 2328], 'p40phox,': [1110, 4613], 'either': [1115, 3374, 4330, 4380], 'inhibiting': [1116], 'stimulating': [1118], 'activity.': [1120, 2199, 5811], 'Assembly': [1121], 'hyperphosphorylation': [1132], '(14El': [1135], 'Benna': [1136, 1161, 1190], 'Faust': [1138, 1163], 'Babior': [1140, 1167, 1272], 'Chem.': [1144, 1171, 1206, 1319, 1577, 1721, 1753, 1777, 1888, 2067, 2099, 2123, 3597, 3629, 3653, 4789, 5076, 5306, 5420, 5520, 5720, 5744, 5911, 5935], '1994;': [1145], '23431-23436Abstract': [1147], '15Inanami': [1154], 'O.': [1155, 1998, 4902, 5009], 'Johnson': [1156], 'McAdara': [1158], 'El': [1160], 'Newburger': [1165], 'P.': [1166], '1998;': [1172], '273:': [1173], '9539-9543Abstract': [1174], '(151)': [1182], '(16El': [1189], 'Dang': [1192], 'P.M.-C.': [1193], 'Gaudry': [1194], 'Fay': [1196], 'Morel': [1198], 'F.': [1199, 1223, 1358, 1481, 1522, 3472, 4195, 4279, 4667, 4731, 4751, 4869, 5087, 5094], 'Hakim': [1200], 'Gougerot-Pocidalo': [1202], '1997;': [1207], '272:': [1208], '17204-17208Abstract': [1209], '(135)': [1217], '17Dusi': [1220], 'Rossi': [1222], '1993;': [1226, 1252, 4969], '296:': [1227, 4970], '367-371Crossref': [1228], '(83)': [1231], 'via': [1234, 1914], 'several': [1235, 1649, 1709], 'kinases': [1236, 1607, 4838], 'kinase': [1239, 3803, 4842, 4947], 'C': [1240, 2725, 3804, 4843], '(18Ding': [1241], 'Badwey': [1243], 'Erickson': [1245], 'R.W.': [1246], 'Balazovich': [1247], 'K.J.': [1248], 'Curnutte': [1249], 'J.T.': [1250], '82:': [1253], '940-947Crossref': [1254], 'Akt': [1259, 4845], '(19Hoyal': [1260], 'C.R.': [1261], 'Gutierrez': [1262], 'Young': [1264], 'Catz': [1266], 'S.D.': [1267, 4808], 'Lin': [1268], 'J.H.': [1269], 'Tsichlis': [1270], 'P.N.': [1271], '100:': [1282, 1377, 4686, 4888], '5130-5135Crossref': [1283], '(155)': [1286], 'Phosphorylation': [1289], 'occurs': [1292], 'own': [1305], 'tandem': [1306, 1916, 4400, 4486, 5266, 5463, 5546], 'domains': [1308, 1641, 2644, 4076, 4488, 4597, 4716, 5356, 5548], '(20Ago': [1309], 'T.': [1310, 1314, 1356, 1364, 1475, 1483, 1503, 1505, 1530, 1746, 1881, 2092, 3622, 4203, 4287, 4665, 4673, 4696, 4698, 4725, 4733, 4759, 4867, 4875, 5299, 5513, 5713, 5904], 'Nunoi': [1311, 1747, 1882, 2093, 3623, 5300, 5514, 5714, 5905], 'Ito': [1313, 1363, 1482, 1504, 4672, 4697, 4732, 4874], 'Sumimoto': [1315, 1367, 1486, 1506, 1749, 1884, 2095, 3625, 4676, 4699, 4736, 4878, 5302, 5516, 5716, 5907], '274:': [1321], '33644-33653Abstract': [1322], '(201)': [1330], '21Groemping': [1333], 'Y.': [1334, 1566, 4778, 5409, 5681], 'Lapouge': [1335], 'Smerdon': [1337], 'S.J.': [1338, 1526, 4199, 4283, 4755], 'Rittinger': [1339], 'Cell.': [1341], '113:': [1343], '343-355Abstract': [1344], '(317)': [1352], '22Ago': [1355], 'Kuribayashi': [1357, 1480, 3471, 4666, 4730, 4868], 'Hiroaki': [1359, 1478, 4668, 4728, 4870], 'Takeya': [1361, 1476, 1867, 4670, 4726, 4872], 'Kohda': [1365, 1484, 1508, 4674, 4701, 4734, 4876], '4474-4479Crossref': [1378, 4687, 4889], '(181)': [1381, 4690, 4892], 'Scholar),': [1383, 1443, 3526, 5433, 5533], 'preventing': [1384, 1627, 4828], 'interaction': [1385, 1629, 2201, 5543], 'p22phox.': [1387, 1644, 1668, 5274], 'latter,': [1389], 'addition': [1391, 5789], 'forming': [1393], 'heterodimer': [1395], '(23Parkos': [1398], 'C.A.': [1399, 1418], 'Allen': [1400], 'R.A.': [1401, 1714, 2060, 3590], 'Cochrane': [1402], 'Jesaitis': [1404, 1425], 'A.J.': [1405, 1426], 'Clin.': [1407], 'Investig.': [1408], '1987;': [1409], '80:': [1410], '732-742Crossref': [1411], '(314)': [1414], '24Parkos': [1417], 'Dinauer': [1419], 'M.C.': [1420], 'Walker': [1421], 'L.E.': [1422, 4168, 5160], 'Rodger': [1423], 'A.A.': [1424], 'Orkin': [1427], 'S.H.': [1428], '1988;': [1436], '85:': [1437], '3319-3323Crossref': [1438], '(244)': [1441], 'provides': [1444, 1670, 2211], 'proline-rich': [1446, 4649], 'bis-SH3': [1452, 4853], 'domain.': [1453], '(the': [1461, 2304], 'domain)': [1463], 'specificity': [1465, 4249, 5183], '3-phosphorylated': [1467], 'lipids,': [1468, 4827], '3-kinase': [1473, 4942], '(25Ago': [1474, 4724], 'Biophys.': [1489, 2026, 3248, 4739, 5098], 'Res.': [1490, 2027, 3249, 4740, 5099, 5689], 'Commun.': [1491, 2028, 3250, 4741, 5100], '287:': [1493, 4743], '733-738Crossref': [1494, 4744], '(92)': [1497, 4747], '26Hiroaki': [1500, 4693], 'Ago': [1502, 4695], 'Nat.': [1510, 1537, 4210, 4294, 4703, 4766], 'Struct.': [1511, 4704], '8:': [1514, 4707], '526-530Crossref': [1515, 4708], '(149)': [1518, 4711], '27Kanai': [1521, 4750], 'Liu': [1523, 4196, 4280, 4752], 'Field': [1525, 4198, 4282, 4754], 'Akbary': [1527, 4200, 4284, 4756], 'Matsuo': [1529, 4202, 4286, 4758], 'G.E.': [1532, 4205, 4289, 4761], 'Cantley': [1533, 4206, 4290, 4762], 'L.C.': [1534, 4207, 4291, 4763], 'Yaffe': [1535, 4208, 4292, 4764], 'M.B.': [1536, 4209, 4293, 4765, 5027], '3:': [1541, 4214, 4298, 4770], '675-678Crossref': [1542, 4215, 4299, 4771], '(498)': [1545, 4218, 4302, 4774], '28Ellson': [1548], 'C.D.': [1549, 1972], 'Andrews': [1550, 1973], 'Stephens': [1552, 1975], 'L.R.': [1553, 1976], 'Hawkins': [1554, 1977], 'P.T.': [1555, 1978], '115:': [1560, 1983], '1099-1105Crossref': [1561, 1984], '29Zhan': [1565, 4777], 'Virbasius': [1567, 4779, 5410], 'J.V.': [1568, 4780, 5411], 'Song': [1569, 4781, 5412], 'Pomerleau': [1571, 4783, 5414], 'D.P.': [1572, 4784, 5415], 'Zhou': [1573, 4785, 5416], 'G.W.': [1574, 4786, 5417], '277:': [1579, 4791, 5422], '4512-4518Abstract': [1580, 4792, 5423], '(98)': [1588, 4800, 5431], 'latter': [1592, 3931, 4396], 'exposed': [1597, 5155], 'mediators,': [1603], 'phosphorylate': [1609], 'itself.': [1611], 'masked': [1619], 'C-terminal': [1622], 'until': [1632], 'becomes': [1636, 4835], 'phosphorylated': [1637], 'bind': [1642, 4240, 4492, 4863, 4926], 'pathways': [1650], 'converge': [1651], 'on': [1652, 1832, 2865, 3067, 4187, 5179, 5387], 'relieving': [1654], 'constraints': [1656, 1684], 'allowing': [1658], 'it': [1659, 1813, 1927, 1935, 4424, 4429, 4464], 'interact': [1661, 5185], 'both': [1663, 1861, 2195, 2527, 3368, 3765, 3949, 4007, 4513, 5255, 5954, 5978], 'one': [1671, 3445], 'important': [1674, 2192, 5496], 'triggers': [1675], 'within': [1685, 1845, 3739, 4446, 4821], 'prevent': [1687], 'agonists.': [1697, 2226], 'Homologs': [1698], 'identified': [1706], 'independently': [1707], 'groups': [1710, 5701], '(31Banfi': [1711, 3587], 'Clark': [1713, 2059, 3589], 'Steger': [1715, 2061, 3591], 'Krause': [1717, 2063, 3593], 'K.H.': [1718, 2064, 3594], '278:': [1723, 1755, 1779, 1890, 2069, 2101, 2125, 3599, 3631, 3655, 5308, 5522, 5722, 5746, 5913, 5937], '3510-3513Abstract': [1724, 2070, 3600], '(405)': [1732, 2078, 3608], '32Takeya': [1735, 2081, 3611], 'Ueno': [1737, 1872, 2083, 3613, 5290, 5504, 5704, 5895], 'N.': [1738, 1873, 2084, 3614, 5291, 5505, 5705, 5896], 'Kami': [1739, 1874, 2085, 3615, 5292, 5506, 5706, 5897], 'Taura': [1741, 1876, 2087, 3617, 5294, 5508, 5708, 5899], 'Kohjima': [1743, 1878, 2089, 3619, 5296, 5510, 5710, 5901], 'Izaki': [1745, 1880, 2091, 3621, 5298, 5512, 5712, 5903], '25234-25246Abstract': [1756, 1891, 2102, 3632, 5309, 5523, 5723, 5914], '(325)': [1764, 1899, 2110, 3640, 5317, 5531, 5731, 5922], '33Geiszt': [1767, 2113, 3643, 5734, 5925], 'Lekstrom': [1769, 2115, 3645, 5736, 5927], 'Witta': [1771, 2117, 3647, 5738, 5929], 'Leto': [1773, 2119, 3649, 5740, 5931], '20006-20012Abstract': [1780, 2126, 3656, 5747, 5938], '(248)': [1788, 2134, 3664, 5755, 5946], 'ours': [1792], '(GenBank™': [1793], 'AF532984).': [1794], 'homologue': [1797], 'referred': [1799], '(NOX': [1803, 1827], 'o': [1804], 'rganizing': [1805], '1),': [1807, 1830], 'based': [1808, 1831, 4186, 5178], 'prediction': [1811, 5200], 'will': [1814, 2505], 'analogous': [1818, 4188, 5390], 'homolog': [1823], 'called': [1825], 'concept': [1834], 'immediate': [1840], 'regulator': [1841], 'electron': [1843], 'transfer': [1844], 'gp91phox.': [1846], 'investigators': [1848], 'demonstrated': [1850], 'using': [1851, 2348, 2356, 2427, 2529, 2659, 2700, 2739, 2893, 2904, 2997, 3006, 3029, 3119, 3296, 3418, 3920, 3994, 4125, 4379], 'transfection': [1852, 5878], 'high': [1854, 2442, 3411, 5130], 'level': [1855, 3530], 'requires': [1860, 1906, 3673], 'NOXA1.': [1864, 3336, 3679], 'et': [1868], 'al.': [1869], '(32Takeya': [1870, 5288, 5502, 5702, 5893], 'showed': [1902, 2375, 2400], 'system': [1905], 'optimal': [1909], 'activity,': [1910], 'domains,': [1918], 'can': [1919], 'form': [1920, 2477], 'p22phox,': [1924, 4494, 5327], 'suggesting': [1925, 5768], 'performs': [1928], 'same': [1930, 2350, 2781, 3842, 4081, 4468, 4579, 4955, 5229, 5334, 5367, 5561, 5583], 'role': [1931, 2171, 2178, 5887], 'does': [1936, 4472], 'providing': [1939, 4992], 'docking': [1941], 'protein.': [1946, 2956, 4511], 'Like': [1947], 'N-terminal': [1952], '(PX': [1955], 'refers': [1956], 'Phox': [1958], 'homology).': [1959], 'variety': [1965], 'proteins,': [1967], 'protein-lipid': [1970], '(28Ellson': [1971], 'protein-protein': [1989], 'interactions': [1990, 4820], '(30Karathanassis': [1991, 5002], 'Stahelin': [1993, 4897, 5004], 'R.V.': [1994, 4898, 5005], 'Bravo': [1995, 4899, 5006], 'Perisic': [1997, 4901, 5008], 'Pacold': [1999, 4903, 5010], 'C.M.': [2000, 4904, 5011], 'Cho': [2001, 4905, 5012], 'W.': [2002, 4906, 5013], 'Williams': [2003, 4907, 5014], 'R.L.': [2004, 4908, 5015], 'EMBO': [2005, 4909, 5016], '21:': [2008, 4912, 5019], '5057-5068Crossref': [2009, 4913, 5020], '(259)': [2012, 4916, 5023], '34Wientjes': [2015], 'F.B.': [2016], 'Reeves': [2017], 'Soskic': [2019], 'V.': [2020, 5092], 'Furthmayr': [2021], '289:': [2030], '382-388Crossref': [2031], '(68)': [2034], 'contrast': [2038, 4246], '(see': [2053], 'below': [2054], '31Banfi': [2057], 'study': [2152], 'undertaken': [2154], 'elucidate': [2156], 'specificity,': [2169], 'NOXO1.': [2182, 3088, 3929, 4352, 4544], 'Our': [2183], 'results': [2184, 4054, 5793], 'implicate': [2185], 'determinant': [2193], 'characteristic': [2207], 'rationale': [2213], 'ability': [2216, 4238, 5375], 'Cells': [2227], 'Reagents—HEK293H': [2229], '(Invitrogen)': [2231], 'were': [2232, 2259, 2341, 2366, 2524, 2618, 2634, 2712, 2795, 2822, 2837, 2863, 2878, 2901, 2918, 2966, 2980, 3024, 3042, 3070, 3094, 3103, 3117, 3149, 3168, 3195, 3222, 3276, 3345, 3389, 3690, 3932, 3948, 3984, 4099, 4112, 4319, 4377, 4523, 4598], 'maintained': [2233, 5984], "Dulbecco's": [2235], 'modified': [2236], "Eagle's": [2237], 'medium': [2238], '10%': [2240], 'fetal': [2241], 'serum,': [2243], '100': [2244, 2249, 2951, 4608], 'units': [2245], 'penicillin,': [2247], 'μg': [2250, 3079, 3183], 'streptomycin.': [2252], 'Luminol,': [2253], 'glutathione,': [2254], 'isopropyl-β-d-thiogalactopyranoside,': [2255], 'horseradish': [2257, 2991, 3286], 'peroxidase': [2258, 3287], 'purchased': [2260], 'from': [2261, 2273, 2279, 2285, 2291, 2296, 2418, 2603, 2908, 3044, 4628, 5476], 'Sigma,': [2262], "Hanks'": [2263, 3052, 3272], 'solution': [2264, 3053], 'containing': [2265, 2663, 2686, 3054, 3174, 3201], '1.26': [2266], 'mm': [2267, 2271, 2859, 2927, 2932], 'calcium': [2268, 3055], '0.91': [2270], 'magnesium': [2272], 'Invitrogen,': [2274], 'pEGFP-endo': [2275], 'DNA': [2277], 'polymerase': [2278], 'Clotech,': [2280], 'restriction': [2281, 2704, 2774], 'endonucleases': [2282], 'ligase': [2284], 'New': [2286], 'England': [2287], 'Biolabs,': [2288], 'glutathione-Sepharose': [2289], '4B': [2290, 2867], 'Amersham': [2292], 'Biosciences,': [2293], 'Topro-3': [2295, 3108], 'Molecular': [2297, 2450, 2909], 'Probes': [2298, 2910], '(Eugene,': [2299, 2911], 'OR).': [2300], 'E39': [2301, 2372, 3177], 'monoclonal': [2302, 2373, 2972, 3179], 'antibody': [2303, 2374, 2408, 2973, 2988, 3180, 3188], 'kind': [2305], 'gift': [2306], 'Dr.': [2308], 'Glenn': [2309], 'Pilkington': [2310], 'colleagues': [2312], 'at': [2313, 2646, 2723, 2839, 2854, 2882, 2938, 2947, 3158], 'Diadexus)': [2314], 'produced': [2316, 5121], 'immunization': [2318], 'BALB/c': [2320], 'mice': [2321], '(235-248),': [2324], 'representing': [2325], 'predicted': [2327, 3428, 4185, 4405, 5177, 5239], 'extracellular': [2329], 'loop': [2330], 'transmembrane': [2333], 'conjugated': [2335, 2352, 2989], 'keyhole': [2337, 2428], 'limpet': [2338, 2429], 'hemocyanin.': [2339], 'Hybridomas': [2340], 'initially': [2342], 'screened': [2343], 'enzyme-linked': [2345], 'immunosorbent': [2346], 'assay': [2347, 2895], 'peptide': [2351, 2360, 2431, 2434], 'BSA': [2354], 'ectodomain': [2359], 'negative': [2363], 'control.': [2364], 'Peptides': [2365], 'synthesized': [2367, 2436], 'SynPep': [2369], '(Dublin,': [2370], 'CA).': [2371], 'bright': [2376], 'indirect': [2377], 'immunofluorescence': [2378, 3918], 'NIH': [2380, 2390, 2397], '3T3': [2381, 2391, 2398], 'expressing': [2383, 3081], 'no': [2386, 3997], 'fluorescence': [2387], 'control': [2389, 2396, 3073], 'Nox1-expressing,': [2393], '62-kDa': [2402], 'band': [2403], 'Western': [2405, 4516], 'blotting.': [2406], 'Anti-NOXO1': [2407], 'IgY': [2411], 'fraction': [2412], 'generated': [2413, 2658, 2733], 'chicken': [2415, 3186, 3923], 'purified': [2417, 2438, 2864, 2875, 4113], 'egg': [2419], 'yolk': [2420], 'Lampire': [2422], 'Biological': [2423], 'Laboratory': [2424], '(Pipersville,': [2425], 'PA),': [2426], 'hemocyanin-conjugated': [2430], 'NOXO1β-(353-370).': [2432], 'reverse': [2440], 'phase': [2441], 'performance': [2443], 'liquid': [2444], 'chromatography': [2445], "Emory's": [2447], 'Microchemical': [2448], 'Facility.': [2449], 'Cloning': [2451], 'cDNA': [2454, 2462, 2522, 2537, 2596, 2609, 2616], 'NOXA1—We': [2458], 'previously': [2459, 2546, 4277], 'reported': [2460, 4276], 'sequence': [2463, 2684, 4650], 'human': [2465], 'NOXO1β': [2466, 2472], '(AF532984,': [2467], 'deposited': [2468], 'July': [2469], '29,': [2470], '2002).': [2471], 'major': [2475, 5886], 'splice': [2476], 'colon': [2480], '4G.': [2481, 5782], 'Cheng,': [2482, 5783], 'all': [2489], 'experiments': [2490, 3861, 5879], 'studies.': [2494], 'details': [2496], 'molecular': [2499], 'cloning': [2500, 2538], 'detailed': [2507], 'separate': [2510], '5G.': [2512], 'Lambeth,': [2517], 'manuscript': [2518, 3586], 'preparation.': [2520], 'All': [2521, 2614], 'clones': [2523], 'sequenced': [2525], 'strands': [2528], 'Applied': [2531], 'Biosystems': [2532], 'model': [2533], '377': [2534], 'sequencer.': [2535], 'Nox3,': [2541], 'Nox4': [2543], 'subcloned': [2600, 2694, 2713, 2796], 'into': [2601, 2695, 2797, 2824, 3026, 3934, 5350], 'pcDNA3.1': [2602, 2731, 2738], 'EST': [2604], 'clone': [2605], 'AA996283': [2606], 'verified': [2611], 'above.': [2613, 3228], 'constructs': [2617], 'made': [2619], 'pcDNA3': [2621], 'except': [2622], 'NOXA1,': [2624, 3371, 4328], 'pCMV-Sport6.': [2628], 'Subcloning—Human': [2629], 'NOXO1-(1-147),': [2631, 4460], 'NOXO1-(148-371)': [2633], 'in-frame': [2636], 'pDsRed2': [2638, 2697, 3076], 'C1': [2639, 2698], '(Clontech)': [2640, 2716], 'generate': [2642, 2718, 2802], 'fused': [2645, 2722, 3747, 3976, 4426, 4458], 'their': [2647, 2724], 'N': [2648], 'termini': [2649, 2726], 'red': [2652, 3705, 3750, 4373], 'DsRed2.': [2655], 'NOXO1(R40Q)': [2656, 4338], 'primer': [2661, 2740, 2744, 2765], '(5′-GCCTGAATTCGTCCCAACTCTGGCGCACGAAGGTGTCGC-3′)': [2662], 'naturally': [2669], 'occurring': [2670], '3′': [2671], 'EcoRI': [2672, 2701], 'site.': [2673, 2689, 3431], '5′': [2679], 'corresponding': [2680], 'vector': [2683, 3012, 3014, 3349, 3405, 4323], 'KpnI': [2688, 2703], 'PCR': [2691], 'product': [2692, 5047], 'plasmid': [2699, 3077, 3351, 3399, 4325], 'enzymes.': [2705], 'For': [2706], 'studies,': [2708, 5207], 'h-Nox1,': [2709], 'pEGFP-N1': [2715], 'EGFP.': [2728], 'Nox1(P409H)': [2729], 'amplifying': [2735], '1': [2741, 2748, 2942, 2969, 3106, 3162, 3218, 3310], '(5′-TTGGGGTCACCCACTTTGCTTCTATCTTGAAATCC-3′)': [2742], '2': [2745, 2766, 3123, 3202, 3210, 4434], '(5′-GGGAAGCTTTCAAAAATTTTCTTTGTTGAAGTA-3′).': [2746], 'Primer': [2747], 'encodes': [2749], 'P409H': [2751], '(italics)': [2753], 'BstE': [2756], 'II': [2757], '(underlined,': [2759], 'originally': [2760], 'Nox1),': [2763], 'introduces': [2767], 'HindIII': [2769], '(underlined).': [2771], 'Using': [2772, 2788, 4512], 'sites,': [2775], 'amplified': [2777], 'fragment': [2778], 'replaced': [2779], 'excised': [2782], 'pcDNA3.1.': [2787], 'similar': [2790, 3820, 3851, 4502, 4569], 'strategy,': [2791], 'NOXO1-(1-147)': [2792, 4387], 'NOXO1-(1-147)R40Q': [2794], 'pGEX-4T-3': [2798], '(Amersham': [2799], 'Biosciences)': [2800], 'GST': [2803, 2954], 'fusion': [2804, 2876, 2955, 3083, 3696, 3871, 3882, 3904, 3910, 3982, 4011, 4105, 4369, 4551], 'GST.': [2808], 'Overexpression': [2809], 'Purification': [2811], 'Domain': [2815, 4358], 'NOXO1—Plasmids': [2817], 'encoding': [2818, 3140, 3352, 3400, 4326, 4367], 'GST-NOXO1-(1-147)': [2819], 'GST-NOXO1-(1-147)R40Q': [2821], 'transformed': [2823], 'Escherichia': [2825], 'coli': [2826, 4103], 'strain': [2827], 'BL21': [2828], '(DE3)': [2829], 'Gold': [2830], '(Stratagene,': [2831], 'La': [2832], 'Jolla,': [2833], 'CA),': [2834], 'cultures': [2836], 'grown': [2838, 3063], '22': [2840, 2855], '°C': [2841, 2856, 2884, 2949], 'OD600': [2844], '0.6.': [2846], 'Protein': [2847, 2889, 4363, 4632], 'induced': [2850], 'h': [2853, 2943], '0.2': [2858], 'isopropyl-β-d-thiogalactopyranoside.': [2860], 'Fusion': [2861, 4110], 'gutathione-Sepharose': [2866], 'resin': [2868], 'according': [2869, 3034, 3240], "manufacturer's": [2872, 2915, 3036], 'instructions.': [2873, 3037], 'dialyzed': [2879], 'against': [2880], 'PBS': [2881], '4': [2883, 2948], 'buffer': [2887, 2937, 3173, 3200, 3273], 'changes.': [2888], 'concentration': [2890, 3397], 'measured': [2892, 3235, 4124], '(Bio-Rad).': [2896], 'Phospholipid': [2897], 'Binding—Lipid': [2898], 'studies': [2900, 3578, 3919, 5536, 5624], 'carried': [2902, 3134, 3823, 3916, 3992], 'out': [2903, 3135, 3917, 3993, 5203], 'PIP': [2906], 'array™': [2907], 'OR)': [2912], 'following': [2913, 3796, 5473], 'protocol.': [2916], 'Membranes': [2917, 2979], 'incubated': [2920, 2967, 2982, 3154, 3169, 3196], '3%': [2922, 3156, 3171, 3198], 'fatty': [2923], 'acid-free': [2924], 'BSA/TBS-T': [2925], '(20': [2926], 'Tris,': [2928], 'pH': [2929], '7.5,': [2930], '136': [2931], 'NaCl,': [2933], '0.1%': [2934], 'Tween': [2935], '20)': [2936], 'room': [2939, 3159], 'temperature': [2940, 3160], '×': [2941, 3099, 3161, 3268], 'then': [2945, 4123], 'overnight': [2946], 'ng/ml': [2952], 'After': [2957, 3038, 3089, 3145, 3164, 3192], 'washing': [2958], 'three': [2959], 'times': [2960], 'TBS-T': [2962], 'buffer,': [2963], 'μg/ml': [2970, 3107, 3176, 3203, 3211], 'anti-GST': [2971], '(Cell': [2974], 'Signaling': [2975], 'Technology,': [2976], 'Beverly,': [2977], 'MA).': [2978], 'further': [2981, 5617, 5828], '1:': [2984], '5000': [2985], 'rabbit': [2986], 'anti-mouse': [2987, 3207], 'peroxidase,': [2992], 'chemiluminescence': [2994], 'developed': [2996], 'SurperSignal®': [2998], 'West': [2999], 'Pico': [3000], 'Chemiluminescent': [3001], 'Substrate': [3002], '(Pierce)': [3003], 'recorded': [3005, 3118, 3223, 3306], 'x-ray': [3007], 'films.': [3008], 'Transient': [3009], 'Transfections—pcDNA3': [3010], '(empty': [3011], 'harboring': [3015], 'and/or': [3018], 'alone': [3020, 4418, 4574, 5357], 'combination)': [3023], 'HEK293H': [3027], 'FuGENE': [3030], '6': [3031, 4412, 4451], '(Roche': [3032], 'Diagnostics)': [3033], '48': [3039, 3090, 3146], 'h,': [3040, 3091, 3147], 'removed': [3043], 'well': [3046, 3262], 'washed': [3048], 'twice': [3049], 'cold': [3051], 'magnesium.': [3057], 'Intracellular': [3058], 'Localization': [3059], 'NOXO1—HEK293H': [3061], '∼40%': [3065], 'confluence': [3066], 'cover': [3068], 'slips': [3069], 'recombinant': [3075], '(0.5': [3078], 'each)': [3080], 'fixed': [3095, 3150], '4%': [3097], 'paraformaldehyde': [3098], '15': [3100], 'min': [3101, 3111], 'stained': [3104], '10': [3110], 'visualize': [3113], 'nuclei.': [3114], 'Fluorescence': [3115, 3220], 'images': [3116, 3221], 'Zeiss': [3121], 'Axioplan': [3122], 'LSM': [3124], '510': [3125], 'Meta': [3126], 'Laser': [3127], 'Scanning': [3128], 'Confocal': [3129], 'Microscope': [3130], 'System.': [3131], 'Immunofluorescence': [3132], 'after': [3136], 'cotransfection': [3137], 'vectors': [3139], 'holoproteins.': [3144], 'above': [3152], 'BSA/PBS': [3157, 3172, 3199], 'h.': [3163, 3191, 3219, 3311], 'extensive': [3165], 'washing,': [3166, 3193], '2.83': [3175], 'anti-Nox1': [3178], 'plus': [3181, 3282, 4329], '3.0': [3182], 'anti-NOXO1': [3185], 'polyclonal': [3187], 'Alexa': [3204, 3212], 'Fluor488': [3205], 'goat': [3206, 3214], 'IgG': [3208, 3216], 'Fluor555': [3213], 'anti-chicken': [3215], 'confocal': [3225], 'microscopy': [3226], 'Measurement': [3229], 'Reactive': [3231, 3315], 'Oxygen—Reactive': [3232], 'luminol': [3237, 3281], 'luminescence,': [3238], 'essentially': [3239], 'Ref.': [3242], '35Allen': [3243], 'R.C.': [3244], 'Loose': [3245], 'L.D.': [3246], '1976;': [3251], '69:': [3252], '245-252Crossref': [3253], '(462)': [3256], 'Scholar.': [3258], 'Briefly,': [3259], 'each': [3261], '96-well': [3265], 'plate,': [3266], '5': [3267, 4335], '105': [3269], 'calcium/magnesium': [3275], 'mixed': [3277], '200': [3279], 'μm': [3280], '0.32': [3283], 'unit': [3284], '200-μl': [3290], 'total': [3291], 'volume.': [3292], 'Luminescence': [3293], 'quantified': [3295], 'LumiCount™': [3298], 'luminometor': [3299], '(Packard,': [3300], 'Meiden,': [3301], 'CT),': [3302], 'luminescence': [3304], 'every': [3307], 'minute': [3308], 'Reconstitution': [3312], 'Nox1-dependent': [3314, 3324, 4345, 5380], 'Oxygen': [3316], 'Generation': [3317], 'NOXA1—In': [3321], 'Fig.': [3322, 3712, 3815, 3867, 3943, 4004, 4334, 4411, 4450], '1,': [3323, 3868], 'activity': [3325, 3363, 3381, 4056, 5595, 5771, 5818], 'reconstituted': [3327], 'co-transfecting': [3329, 3825], 'A,': [3338], 'always': [3341, 3390], 'present,': [3342], 'co-transfected': [3346, 4320], 'empty': [3348, 3404, 4322], 'individually': [3356], 'combination.': [3359], 'As': [3360, 3709, 3832, 3940], 'shown,': [3362, 3833], 'required': [3364, 5283], 'presence': [3366], 'when': [3373, 3570, 3980, 4423, 4455], 'omitted,': [3376], 'only': [3377], 'extremely': [3378], 'low': [3379, 3529, 3542, 3563], 'basal': [3380], 'seen.': [3383], 'B,': [3385], '(introduced': [3392], 'co-transfection),': [3394], 'Nox1(P409H),': [3402, 3422], 'varied.': [3407], 'Data': [3408], 'demonstrate': [3409], 'levels': [3412, 3543, 5981], 'achieved': [3417], 'mutated': [3425, 4088], 'corresponds': [3434, 4028], 'inactivating': [3437], 'variant': [3446], 'chronic': [3448], 'granulomatous': [3449], 'disease': [3450], '(36Segal': [3451], 'Med.': [3454], 'Today.': [3455], '1996;': [3456, 3490, 4634], '2:': [3457], '129-135Abstract': [3458], '(108)': [3464], '37Roos': [3467], 'Boer': [3469], 'Meischl': [3473], 'Weening': [3475], 'Ahlin': [3479], 'Nemet': [3481], 'Hossle': [3483], 'Bernatowska-Matuszkiewicz': [3485], 'Middleton-Price': [3487], '87:': [3491], '1663-1681Crossref': [3492], 'earlier': [3498], 'publication': [3499], 'we': [3527, 3914, 5322], 'observed': [3528], 'fibroblasts': [3534], 'alone.': [3538], 'We': [3539], 'detected': [3541], 'mRNA': [3548], 'account': [3560], 'seen': [3566, 3854, 3979, 4000, 4524], 'introduced.': [3573], 'data': [3576, 3811, 4135, 5566, 5607], 'confirm': [3577], 'appeared': [3580], 'preparation': [3583], 'concluded': [3668], 'Co-localization': [3680], 'Transfected': [3686], 'Cells—Nox1': [3687], '(GFP)': [3702], '(DsRed2).': [3708], 'shown': [3710, 3865, 3941, 5280], '2,': [3713, 3756, 3778, 3816], 'left': [3714], 'upper': [3715, 3758, 3780, 3857], 'panel,': [3716], 'additional': [3725, 5844], 'intracellular': [3727], 'structures': [3728, 3965, 3978, 4445], 'co-localize': [3730, 5331], '(data': [3731, 3886, 4528], 'shown)': [3733], 'endosomal': [3736, 3892], 'marker': [3737], '(EGFP-endo)': [3738], 'compartment': [3742, 5562], 'therefore': [3745], 'represent': [3746], 'endosomes.': [3748], 'version': [3752], '(Fig.': [3755, 3777, 4118, 4132, 4273, 4575], 'middle': [3757], 'panel)': [3759, 3781], 'appears': [3760, 4652], 'structures,': [3771, 3843], 'yellow': [3774], 'merged': [3775], 'image': [3776], 'right': [3779], 'confirms': [3782], 'co-localize.': [3787], 'location': [3789, 3893, 4031], 'components': [3792], 'did': [3793], 'change': [3795], 'treatment': [3797], 'activator': [3805], 'phorbol': [3806, 4066, 5791, 5831], '12-myristate': [3807], '13-acetate': [3808], '(10': [3809], 'nm;': [3810], 'shown).': [3813, 3888, 4530], 'lower': [3817], 'panels,': [3818], 'experiment': [3821], 'out,': [3824], 'NOXO1-DsRed': [3826], 'p22phox-GFP': [3828], 'co-localized': [3839], 'internal': [3849, 4443, 4819], 'those': [3853, 3864], 'panels.': [3858], 'co-transfection': [3860, 4053], 'such': [3862, 4064, 4839, 5847, 5860], 'active': [3874], 'supporting': [3876], 'generation,': [3878, 5382, 5800], 'whereas': [3879], 'Nox1-GFP': [3881, 3909], 'inactive': [3885], 'Because': [3889], 'partial': [3891, 5760], 'represented': [3896], 'artifact': [3898], 'overexpression': [3900], 'unnatural': [3903], 'because': [3907], 'inactive,': [3913], 'mouse': [3921], 'antibodies': [3924], 'specific': [3925], 'non-fusion': [3938], 'proteins.': [3939], '3,': [3944], 'membrane.': [3953], 'small': [3957], 'percentage': [3958], 'punctate': [3964], 'throughout': [3966, 4420, 4496, 4566], 'cell,': [3968, 4422, 4568], 'neither': [3970], 'endosome-like': [3977], 'expressed.': [3985], 'When': [3986, 4831], 'identical': [3988, 4504], 'immunostaining': [3989, 3998, 4008], 'procedure': [3990], 'non-transfected': [3995], '(lower': [4001], 'panels': [4002], '3).': [4005], 'indicate': [4013], '(or': [4025], 'phagosomal': [4026], 'membrane)': [4027], 'phagocytes.': [4038], 'Membrane': [4039], 'co-localization': [4040, 5251], 'unstimulated': [4045], 'consistent': [4048, 5383], 'finding': [4051], 'added': [4062], 'ester.': [4067], 'Lipid': [4068, 4120, 4308, 4353], 'Binding': [4069, 4309, 4354], 'Domain—The': [4074], '(NOXO1-(1-147)),': [4079], 'construct': [4082], 'arginine': [4085, 4182], '40': [4086, 4183], 'glutamine,': [4091], '(p47phox-1-144))': [4098], 'S-transferase.': [4109], 'obtain': [4115], 'homogeneous': [4116], '4A).': [4119], 'overlay': [4126], 'blotting': [4127], 'under': [4129], '"Experimental': [4130], 'Procedures"': [4131], '4B).': [4133], 'show': [4136, 5209, 5323, 5537], 'significant': [4137, 5447, 5484, 5816], '3,5-bisphosphate,': [4141], '5-phosphate,': [4143], '4-phosphate,': [4146], 'minor': [4148], '3,4-bisphosphate.': [4152, 4940], 'Notably,': [4153], 'there': [4154, 5805, 5814], 'strong': [4156], 'monophosphorylated': [4159, 5134], 'phosphatidylinositols': [4160, 5135], '(38Hokin': [4167, 5159], 'Annu.': [4169, 5161], 'Rev.': [4170, 5162], '1985;': [4172, 5164], '54:': [4173, 5165], '205-235Crossref': [4174, 5166], '(484)': [4177, 5169], 'Mutation': [4180, 4306], 'mutations': [4189], 'p40phox': [4193, 4925], '(27Kanai': [4194, 4278], 'disrupt': [4222], 'binding.': [4224], 'confirmed': [4227], 'C,': [4229], 'shows': [4231, 4336, 4453, 4563], 'interferes': [4235, 4588, 5245, 5345], 'phosphate': [4243], 'bound': [4260], 'most': [4261], 'tightly': [4262, 5469], '3,4-bisphosphate': [4265], 'lesser': [4269], 'extent,': [4270], '3-phosphate': [4272], '4D),': [4274], 'Affecting': [4307], 'Decreases': [4310], 'Ability': [4312], 'Activate': [4316], 'Generation—Cells': [4318], 'NOXO1(R40Q).': [4333], 'considerably': [4340], 'less': [4341], 'potent': [4342], 'than': [4348, 4607], 'wild': [4350], 'type': [4351], 'Localizes': [4361], 'Plasma': [4365], 'Membrane—Plasmids': [4366], 'DsRed2': [4376, 4417, 4456, 4510, 4550], 'constructed': [4378], 'holoprotein': [4382], 'NOXO1-(1-371),': [4383], 'NOXO1-(148-371).': [4394], 'participate': [4407, 4654], 'interactions.': [4410], 'demonstrates': [4413], 'while': [4415, 5801, 5813], 'holo-NOXO1,': [4428], 'Figs.': [4433], 'some': [4442, 5851, 5858], 'compartment.': [4449, 5461], 'structures/compartments': [4470], 'holoprotein.': [4474], 'However,': [4475, 5320, 5877], 'NOXO1-(148-371),': [4476], 'retains': [4484], 'pattern': [4501], 'non-fused': [4509], 'RT-PCR': [4514], 'blotting,': [4517], 'message': [4519], 'respectively,': [4522], 'contributes': [4537], 'significantly': [4538], 'Consistent': [4545], 'interpretation,': [4548], 'holo-NOXO1(R40Q)': [4554], 'fails': [4555], 'localize': [4557, 5557], 'distribution': [4565], 'DsRed': [4573], '7).': [4576], 'disrupts': [4584, 5250], 'intact': [4594], 'conserved': [4602], 'found': [4604], 'more': [4606], 'eukaryotic': [4609], 'phospholipase': [4614, 5049], 'D,': [4615, 5050], 'Cpk': [4617], 'class': [4618], '3-kinases,': [4621], 'sorting': [4622], 'nexins,': [4623], 'Bem1': [4625], 'Scd2': [4627], 'yeast': [4629], '(39Ponting': [4630], 'C.P.': [4631], '5:': [4635], '2353-2357Crossref': [4636], '(266)': [4639], 'intradomain': [4656], 'C-SH3': [4660], '(22Ago': [4664, 4866], 'Moreover,': [4714], 'phosphates': [4723], '40Sato': [4803], 'T.K.': [4804], 'Overduin': [4805], 'Emr': [4807], 'Science.': [4809], '294:': [4811], '1881-1885Crossref': [4812], '(204)': [4815], 'mask': [4823], 'association.': [4830], 'hyperphosphorylated': [4836], 'releases': [4846], 'inhibition,': [4847], 'permits': [4849], 'allows': [4858], '30Karathanassis': [4895], '3-kinase,': [4933], 'showing': [4934], 'greatest': [4936], 'affinity': [4937, 5131], 'Phosphatidylinositol': [4941], 'regulated': [4945, 5953], 'inflammatory': [4956], 'stimuli': [4957, 5060, 5158], '(41Arcaro': [4963], 'Wymann': [4965], 'M.P.': [4966], '297-301Crossref': [4971], '(1053)': [4974], 'second': [4983], 'interacts': [4988, 5272], 'phosphatidic': [4990, 5000], 'acid,': [4991], 'synergistic': [4994], 'inositol': [4997], 'acid': [5001, 5044], '42Yaffe': [5026], 'Structure': [5028], '(Camb.).': [5029], '10:': [5031], '1288-1290Abstract': [5032], '(17)': [5040], 'Phosphatidic': [5043], 'response': [5058], '(43Bauldry': [5066], 'S.A.': [5067], 'Bass': [5068], 'D.A.': [5069], 'Cousart': [5070], 'S.L.': [5071, 5683], 'McCall': [5072], 'C.E.': [5073], '1991;': [5077], '266:': [5078], '4173-4179Abstract': [5079], '44Rossi': [5086], 'Grzeskowiak': [5088], 'Della': [5090], 'Bianca': [5091], 'Calzetti': [5093], 'Gandini': [5095], '1990;': [5101], '168:': [5102], '320-327Crossref': [5103], '(122)': [5106], 'possesses': [5112], 'respond': [5116], 'activation.': [5124], '4-P': [5137], 'constituents': [5145], 'unlike': [5173], 'phospholipid': [5181], 'stimulated': [5195], 'agonist.': [5198], 'borne': [5202], 'located.': [5234], 'itself': [5259, 5555], 'holo-NOXO1.': [5262], 'Holo-NOXO1': [5263], 'Nox1-supported': [5285], 'herein': [5321], 'even': [5325], 'though': [5326], 'compartments,': [5336], 'co-localization,': [5347], 'releasing': [5348], 'cytosol.': [5352], 'sufficient': [5360, 5553], 'assemble': [5362], 'Nox1/p22phox.': [5365], 'support': [5379], 'effect': [5386], 'localization.': [5388], 'An': [5389], 'failed': [5399], 'interfere': [5401], '(29Zhan': [5408], 'indicating': [5434], 'association': [5438], 'biomolecules': [5441], '(such': [5442], 'p22phox)': [5444], 'provide': [5446, 5483, 5971], 'energy': [5449, 5486], 'cooperates': [5451], 'localizing': [5456, 5578], 'appropriate': [5460], 'phosphorylation-induced': [5474], 'release': [5475], 'inhibition': [5477], 'auto-inhibitory': [5480], 'While': [5493], 'importance': [5570], 'wherein': [5585], 'accounting': [5589], 'constitutive': [5594, 5956, 5979], 'do': [5608], 'eliminate': [5610], 'possibility': [5612], 'agonist-simulated': [5620], 'Indeed,': [5622], 'recent': [5623], 'involvement': [5628], 'PDGF': [5632], 'angiotensin': [5634], 'II-stimulated': [5635], 'vascular': [5639, 5874], 'smooth': [5640], 'muscle': [5641], '45Lassegue': [5670], 'Yin': [5676], 'Q.': [5677], 'Akers': [5678], 'Zhang': [5680], 'Grant': [5682], 'Circ.': [5688], '88:': [5691], '888-894Crossref': [5692], '(758)': [5695], 'noted': [5759], 'lines,': [5767], 'partially': [5774, 5777], 'consitutive': [5775, 5817], 'activable.': [5778], 'our': [5780], 'experiments,': [5781], 'ester': [5792, 5832], '20-50%': [5796], 'increase': [5797, 5809], 'COS7': [5803], '∼2-fold': [5808], 'Thus': [5812], 'lines': [5821], 'tested': [5822], 'thus': [5823, 5882], 'far,': [5824], 'magnitude': [5826], 'type-specific.': [5835], 'Such': [5836, 5968], 'involve': [5839, 5863], 'participation': [5841, 5865], 'activable': [5845], 'component': [5846], 'yet': [5853], 'uncharacterized': [5854], 'component.': [5855], 'Alternatively,': [5856], 'cases,': [5859], 'might': [5862, 5951], 'implicated': [5872], 'generation.': [5876], 'far': [5883], 'supported': [5884], 'involving': [5958, 5965], 'acutely': [5962], 'agonist-regulated': [5963], 'components.': [5967], 'would': [5970], 'means': [5975], 'could': [5982, 5992], '(using': [5985], 'expression)': [5987], 'agonist-specific': [5989], 'elevation': [5991], 'still': [5993], 'achieved.': [5995]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014944893', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-15T16:29:38.879163', 'created_date': '2016-06-24'}
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