Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and Src

Name: Work Video:
Duration: 3 min 30 s
Daniel N. Streblow; Jennifer Vomaske; Patsy Smith; Ryan Melnychuk; Laurel Hall; Dora Pancheva; Martine J. Smit; Paola Casarosa; David D. Schlaepfer; Jay A. Nelson
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'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1554666404', 'https://openalex.org/W1577573926', 'https://openalex.org/W1608297032', 'https://openalex.org/W1614726407', 'https://openalex.org/W1766423076', 'https://openalex.org/W1836679973', 'https://openalex.org/W1938724940', 'https://openalex.org/W1956645860', 'https://openalex.org/W1964376417', 'https://openalex.org/W1971903936', 'https://openalex.org/W1993297416', 'https://openalex.org/W1994637853', 'https://openalex.org/W1998151356', 'https://openalex.org/W2001197100', 'https://openalex.org/W2008808301', 'https://openalex.org/W2013130521', 'https://openalex.org/W2016074757', 'https://openalex.org/W2017214646', 'https://openalex.org/W2028691987', 'https://openalex.org/W2032612463', 'https://openalex.org/W2036276955', 'https://openalex.org/W2036918003', 'https://openalex.org/W2041768631', 'https://openalex.org/W2042819854', 'https://openalex.org/W2047533646', 'https://openalex.org/W2061404129', 'https://openalex.org/W2093603781', 'https://openalex.org/W2103212167', 'https://openalex.org/W2103363752', 'https://openalex.org/W2110841670', 'https://openalex.org/W2142042013', 'https://openalex.org/W2146939406', 'https://openalex.org/W2151312020', 'https://openalex.org/W2154560913', 'https://openalex.org/W2160262946', 'https://openalex.org/W2161539371', 'https://openalex.org/W2400391602', 'https://openalex.org/W93284168'], 'related_works': ['https://openalex.org/W4299484413', 'https://openalex.org/W4234113840', 'https://openalex.org/W4230235187', 'https://openalex.org/W2554699980', 'https://openalex.org/W2165915920', 'https://openalex.org/W2144020592', 'https://openalex.org/W2126892899', 'https://openalex.org/W2072583244', 'https://openalex.org/W1926397135', 'https://openalex.org/W180669350'], 'abstract_inverted_index': {'The': [0, 204, 625, 1532, 1705, 1948, 1969, 2065, 2445, 2572, 2704, 2724, 2755, 3054, 3456, 4156, 4173, 4188], 'human': [1, 205, 863, 902, 1219, 2266, 2510], 'cytomegalovirus-encoded': [2, 206], 'chemokine': [3, 207, 657, 662, 667, 984, 1102, 1464, 3608], 'receptor': [4, 208, 3609, 4200], 'US28': [5, 47, 84, 97, 116, 121, 151, 209, 251, 288, 301, 320, 325, 355, 679, 808, 941, 1038, 1066, 1177, 1206, 1332, 1337, 1395, 1456, 2175, 2196, 2201, 2218, 2490, 2872, 2887, 3223, 3387, 3445, 3581, 3594, 3610, 3696, 3819, 3862, 3906, 3966, 3982, 4043, 4091, 4115, 4123, 4174, 4245, 4269], 'induces': [6, 210], 'arterial': [7, 211, 810, 3612], 'smooth': [8, 212, 811, 865, 904, 2269], 'muscle': [9, 213, 417, 447, 812, 866, 905, 2270], 'cell': [10, 80, 214, 284, 433, 463, 813, 867, 890, 906, 929, 1451, 2032, 2271], '(SMC)': [11, 215, 814], 'migration;': [12, 216], 'however,': [13, 217], 'the': [14, 50, 71, 86, 107, 110, 127, 139, 145, 168, 218, 254, 275, 290, 311, 314, 331, 343, 349, 372, 483, 675, 945, 973, 982, 1041, 1071, 1336, 1394, 1406, 1443, 1470, 1492, 1501, 1505, 1511, 1543, 1549, 1590, 1715, 1957, 1976, 1983, 2016, 2040, 2069, 2084, 2090, 2101, 2117, 2179, 2193, 2256, 2454, 2492, 2589, 2732, 2775, 2829, 2868, 2879, 2901, 2907, 2965, 3000, 3008, 3021, 3065, 3074, 3099, 3150, 3177, 3233, 3271, 3281, 3316, 3374, 3396, 3451, 3494, 3533, 3559, 3606, 3701, 3791, 3801, 3821, 3852, 3866, 3871, 3888, 3934, 3952, 3968, 4000, 4075, 4111, 4134, 4152, 4203, 4252, 4266, 4271, 4298], 'underlying': [15, 219], 'mechanisms': [16, 220], 'involved': [17, 221, 1166, 1913, 4113], 'in': [18, 98, 150, 198, 222, 302, 354, 402, 496, 507, 1167, 1195, 1215, 1393, 1455, 1709, 1725, 1914, 2023, 2039, 2206, 2250, 2276, 2291, 2316, 2395, 2484, 2502, 2563, 2614, 2652, 2659, 2677, 2699, 2743, 2801, 2831, 3041, 3051, 3103, 3438, 3460, 3464, 3481, 3512, 3527, 3575, 3649, 3665, 3677, 3688, 3710, 3725, 3806, 3870, 4056, 4074, 4084, 4095, 4104, 4114, 4142, 4278], 'this': [19, 62, 223, 266, 818, 1168, 2188, 3557, 3835, 3894, 3937, 3956], 'process': [20, 35, 224, 239, 634], 'are': [21, 225, 1165, 1447, 1515, 2233, 4193], 'unclear.': [22, 226], 'We': [23, 43, 227, 247, 803, 1092, 4108, 4119], 'have': [24, 228, 646, 804, 1093, 1173, 1390, 1791, 2110, 2226, 3602, 3731], 'previously': [25, 229, 805, 1094, 2338, 2459, 2926, 3186, 3400, 3603, 3733], 'shown': [26, 230, 1210, 1764, 4083, 4141], 'that': [27, 36, 46, 61, 115, 188, 231, 240, 250, 265, 319, 392, 476, 807, 817, 1030, 1096, 1162, 1176, 1398, 1445, 1693, 2082, 2112, 2129, 2174, 2187, 2217, 2232, 2243, 2898, 3323, 3605, 3653, 3730, 3851, 3893, 3962, 3991, 4042, 4050, 4244], 'US28-mediated': [28, 67, 157, 199, 232, 271, 361, 403, 1097, 1147, 1203, 2252, 3666, 3689, 3992, 4067], 'SMC': [29, 68, 158, 202, 233, 272, 362, 406, 1098, 1148, 1204, 2115, 2199, 2259, 2511, 2918, 3105, 3108, 3117, 3613, 3667, 3690, 3727, 3993, 4068, 4089], 'migration': [30, 159, 234, 363, 815, 1099, 1149, 1459, 1588, 1711, 2135, 2289, 2921, 3109, 3159, 3614, 3994, 4072], 'occurs': [31, 104, 235, 308, 1194, 2205, 4264], 'by': [32, 162, 236, 366, 1104, 1153, 1461, 1542, 1714, 1903, 2007, 2720, 2728, 2814, 2827, 2864, 3063, 3073, 3128, 3170, 3175, 3231, 3280, 3301, 3382, 3391, 3580, 3812, 3828, 3847, 3997, 4127, 4160, 4183, 4284], 'a': [33, 89, 99, 130, 195, 237, 293, 303, 334, 399, 473, 478, 504, 631, 655, 659, 967, 1158, 1196, 1895, 1980, 2019, 2028, 2079, 2207, 2854, 2969, 3031, 3275, 3289, 3513, 3539, 3650, 3660, 3671, 3686, 3824, 3971, 3984, 4045, 4105, 4279], 'ligand-dependent': [34, 100, 238, 304, 1197, 1448, 2208, 3651], 'is': [37, 64, 134, 160, 241, 268, 338, 364, 472, 502, 1150, 1200, 1466, 1699, 1892, 1912, 1953, 1962, 2005, 2132, 2190, 2211, 3670, 3854, 3896, 3995, 4158, 4166, 4254], 'sensitive': [38, 135, 242, 339, 3655], 'to': [39, 123, 136, 243, 327, 340, 822, 944, 966, 1024, 1033, 1065, 1181, 1211, 1331, 1491, 1581, 1723, 1727, 1765, 1917, 1975, 1982, 1991, 2015, 2050, 2074, 2100, 2197, 2213, 2420, 2709, 2964, 2999, 3014, 3020, 3097, 3154, 3293, 3572, 3656, 3722, 3805, 3818, 3864, 3886, 3899, 3965, 4179, 4195, 4249, 4258, 4302], 'protein-tyrosine': [40, 52, 244, 256, 874, 913, 1550, 2181, 3938], 'kinase': [41, 58, 91, 112, 245, 262, 295, 316, 873, 875, 878, 912, 914, 917, 1551, 1697, 1897, 1959, 2293, 2498, 2504, 2678, 2700, 2705, 3712, 3808, 3826, 3843, 3868, 3890, 3939, 3975, 4047], 'inhibitors.': [42, 246], 'demonstrate': [44, 187, 248, 391, 2173, 2242], 'here': [45, 249], 'signals': [48, 252], 'through': [49, 167, 253, 371, 1070, 1183, 1221, 1469, 1589, 2178, 4256], 'non-receptor': [51, 255, 2180, 3672], 'kinases': [53, 257, 2182], 'Src': [54, 94, 118, 140, 149, 193, 258, 298, 322, 344, 353, 397, 2183, 2246, 2891, 3102, 3599, 3932, 3974, 4051, 4062, 4126, 4150, 4177, 4250, 4288], 'and': [55, 60, 82, 166, 180, 192, 201, 259, 264, 286, 370, 384, 396, 405, 435, 465, 498, 510, 538, 639, 643, 664, 672, 816, 892, 931, 964, 979, 981, 1074, 1199, 1218, 1224, 1450, 1523, 1529, 1584, 1786, 1797, 1961, 1973, 2056, 2077, 2089, 2184, 2186, 2238, 2245, 2263, 2285, 2290, 2304, 2332, 2400, 2407, 2423, 2438, 2453, 2567, 2597, 2606, 2626, 2629, 2639, 2674, 2696, 2717, 2722, 2736, 2747, 2783, 2793, 2810, 2841, 2844, 2873, 2906, 3012, 3081, 3132, 3173, 3288, 3373, 3386, 3475, 3489, 3530, 3582, 3598, 3782, 3800, 3810, 3814, 3834, 3928, 3955, 3973, 4004, 4165, 4170, 4296], 'focal': [56, 260, 876, 915, 1695, 1949, 1992], 'adhesion': [57, 261, 424, 454, 877, 916, 1696, 1950], '(FAK)': [59, 263, 1698], 'activity': [63, 267, 819, 1193, 1798, 2131, 2189, 3836, 3844, 4063], 'necessary': [65, 269], 'for': [66, 270, 1202, 1496, 1517, 1702, 2134, 2192, 2235, 2569, 2711, 2731, 2749, 2867, 2990, 3003, 3124, 3144, 3468, 3516, 3550, 3564, 3662, 3924, 4066, 4198], 'migration.': [69, 203, 273, 407, 1205, 1704, 2200, 2239, 2260, 3106, 3668, 3680], 'In': [70, 274, 515, 1060, 1170, 1758, 2223], 'presence': [72, 276, 2733, 2869, 3872, 4076], 'of': [73, 88, 109, 129, 148, 153, 170, 172, 177, 190, 277, 292, 313, 333, 352, 357, 374, 376, 381, 394, 426, 456, 627, 640, 827, 881, 920, 970, 1037, 1146, 1230, 1463, 1473, 1500, 1510, 1520, 1690, 1694, 1707, 1717, 1761, 1768, 1794, 1894, 1956, 1964, 1971, 1986, 2003, 2018, 2042, 2068, 2097, 2104, 2114, 2136, 2195, 2203, 2230, 2258, 2494, 2582, 2734, 2823, 2856, 2859, 2870, 2904, 2968, 3057, 3068, 3076, 3101, 3142, 3312, 3532, 3596, 3703, 3793, 3823, 3832, 3873, 3905, 3936, 3970, 4077, 4080, 4088, 4099, 4117, 4138, 4154, 4190, 4205, 4273, 4300], 'RANTES': [74, 124, 278, 328, 1063, 1108, 2594, 2780, 3699, 3781, 3816, 3874, 3963], '(regulated': [75, 279], 'on': [76, 280, 429, 459, 886, 925, 1900, 2312, 2506, 2883, 3370, 3379, 3588, 3714], 'activation': [77, 152, 189, 281, 356, 393, 430, 460, 887, 926, 1229, 2103, 2202, 3664, 3702, 4116, 4283], 'normal': [78, 282, 431, 461, 888, 927], 'T': [79, 283, 432, 462, 889, 928], 'expressed': [81, 285, 434, 464, 891, 930, 1111, 3449], 'secreted),': [83, 287], 'stimulates': [85, 289], 'production': [87, 291], 'FAK·Src': [90, 111, 294, 315, 3825, 3842, 3867, 3889, 3953, 4046], 'complex.': [92, 296, 1507], 'Interestingly,': [93, 297, 652, 1328, 3944], 'co-immunoprecipitates': [95, 299], 'with': [96, 138, 164, 300, 342, 368, 522, 635, 674, 1040, 1155, 1179, 2010, 2116, 2255, 2280, 2322, 2576, 2593, 2759, 2779, 2890, 2911, 3095, 3120, 3130, 3224, 3319, 3393, 3477, 3484, 3498, 3538, 3674, 3698, 3778, 3940, 3951, 3987, 3999, 4092, 4125, 4176, 4265, 4275], 'manner.': [101, 305, 4107], 'This': [102, 306, 1192, 2013, 2095, 3268], 'association': [103, 307, 2009, 3935, 4175, 4192], 'earlier': [105, 309], 'than': [106, 310, 1539], 'formation': [108, 128, 312, 332, 2017, 2041, 2493, 3822, 3969], 'complex,': [113, 132, 317, 336, 3891, 3954, 3976, 4048], 'suggesting': [114, 318, 1161, 2128, 2216, 3659, 3850, 3892, 3961, 4049], 'activates': [117, 321, 1067, 1535, 4044], 'before': [119, 323], 'FAK.': [120, 154, 324, 358, 3583, 3704], 'binding': [122, 326, 1028, 1064, 1103, 1330, 1580, 1970, 3531, 3817, 3964, 4201, 4257, 4294], 'also': [125, 329, 519, 1100, 1208, 3562], 'promotes': [126, 330, 2491], 'Grb2·FAK': [131, 335], 'which': [133, 337, 1546, 1911, 1988, 2024, 2210, 3977, 4102], 'treatment': [137, 163, 341, 367, 1154, 2113, 3998, 4087], 'inhibitor': [141, 345], 'PP2,': [142, 346], 'further': [143, 347], 'highlighting': [144, 348], 'critical': [146, 196, 350, 400, 2228, 3675], 'role': [147, 197, 351, 401, 3100, 3661, 3687, 4055], 'Human': [155, 359, 408], 'cytomegalovirus': [156, 360, 409, 864, 903], 'inhibited': [161, 365], 'PP2': [165, 369, 3085, 4093], 'expression': [169, 373, 1796, 3388], 'either': [171, 375, 1105, 4246], 'two': [173, 377], 'dominant': [174, 378, 3113], 'negative': [175, 379, 3114], 'inhibitors': [176, 380, 2119, 4002], 'FAK': [178, 191, 382, 395, 1708, 1762, 1795, 1891, 1916, 1990, 1994, 2025, 2034, 2051, 2058, 2075, 2185, 2204, 2231, 2244, 2483, 2497, 2508, 2631, 2735, 2767, 2874, 3112, 3385, 3447, 3597, 3669, 3684, 3715, 3797, 3918, 3921, 3941, 3972, 4274, 4290, 4301], '(F397Y': [179, 383], 'NH2-terminal': [181, 385, 894, 933], 'amino': [182, 386, 438, 468, 896, 935, 2329], 'acids': [183, 387, 2330], '1–401).': [184, 388], 'These': [185, 389, 2240, 4241], 'findings': [186, 390, 2241, 4242], 'plays': [194, 398, 3685, 4052], 'signaling': [200, 404, 1214, 1347, 1400, 1536, 2021, 2080, 2237, 2253, 3903, 3980], '(HCMV)': [410], '1The': [411], 'abbreviations': [412, 442], 'used': [413, 443, 2394, 2900, 3721], 'are:': [414, 444], 'HCMVhuman': [415, 445], 'cytomegalovirusSMCsmooth': [416, 446], 'cellMCPmonocyte': [418, 448], 'chemoattractant': [419, 449, 869, 908], 'proteinERKextracellular': [420, 450], 'signal-regulated': [421, 451, 872, 911], 'kinasePTKprotein-tyrosine': [422, 452], 'kinaseFAKfocal': [423, 453], 'kinaseHAhemagglutininm.o.i.multiplicity': [425, 455], 'infectionWTwild': [427, 457], 'typeRANTESregulated': [428, 458], 'secretedNTNH2-terminal': [436, 466], '(1–410': [437, 467, 895, 934], 'acids)PP24-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidineMIPmacrophage': [439, 469], 'inflammatory': [440, 470, 633, 900, 939], 'protein.1The': [441], 'protein.': [471, 901, 940], 'ubiquitous': [474], 'herpesvirus': [475], 'establishes': [477], 'life-long': [479], 'latent': [480], 'infection': [481, 485, 882, 921, 2583, 3007, 3094], 'after': [482, 530, 534, 1997, 2031, 3093, 3790, 4163, 4202], 'primary': [484, 3534], 'has': [486, 492, 518, 1207], 'been': [487, 520, 647, 1209, 1391, 3732], 'cleared.': [488], 'Although': [489], 'anti-viral': [490], 'therapy': [491], 'appreciably': [493], 'reduced': [494, 3846], 'disease': [495, 509, 629, 829], 'transplant': [497, 513], 'AIDS': [499], 'patients,': [500], 'HCMV': [501, 517, 653, 2993, 3096, 3121], 'still': [503], 'significant': [505], 'problem': [506], 'congenital': [508], 'bone': [511], 'marrow': [512], 'patients.': [514], 'addition,': [516, 1759, 2224], 'associated': [521, 2254], 'long': [523], 'term': [524], 'diseases': [525], 'such': [526], 'as': [527, 649, 1333, 1335, 1401, 1403, 2027, 2337, 2894, 2925, 3162, 3399, 4263], 'atherosclerosis,': [528], 'restenosis': [529], 'angioplasty,': [531], 'chronic': [532, 632], 'rejection': [533], 'solid': [535], 'organ': [536], 'transplantation,': [537], 'malignancies': [539], '(1.Cobbs': [540], 'C.S.': [541], 'Harkins': [542], 'L.': [543], 'Samanta': [544], 'M.': [545, 1240, 1410, 1615, 1647, 1658, 1746, 1844, 1846, 1854, 2357, 3243], 'Gillespie': [546], 'G.Y.': [547], 'Bharara': [548], 'S.': [549, 732, 747, 1557, 1734, 1742, 2345, 2353, 3342, 4216], 'King': [550], 'P.H.': [551], 'Nabors': [552], 'L.B.': [553], 'Cobbs': [554], 'C.G.': [555], 'Britt': [556], 'W.J.': [557], 'Cancer': [558], 'Res.': [559, 1010], '2002;': [560, 1883], '62:': [561], '3347-3350PubMed': [562], 'Google': [563, 598, 623, 711, 740, 801, 861, 962, 1000, 1018, 1058, 1090, 1143, 1261, 1302, 1326, 1387, 1437, 1483, 1575, 1612, 1638, 1668, 1687, 1756, 1784, 1809, 1837, 1868, 1889, 1946, 2169, 2367, 2389, 2481, 2535, 2557, 2958, 3218, 3264, 3364, 3432, 3645, 3765, 4037, 4239], 'Scholar,': [564, 576, 599, 712, 741, 783, 1001, 1262, 1303, 1613, 1639, 1669, 1810, 1838, 1869, 2368, 2536], '2.Melnick': [565], 'J.L.': [566, 949, 1420, 1776], 'Adam': [567], 'E.': [568, 578, 764, 789, 840, 1122, 1677, 1932, 2148, 2521, 2937, 3197, 3344, 3411, 3624, 3744, 4016], 'DeBakery': [569], 'M.E.': [570, 714], 'Infect.': [571], 'Med.': [572, 1605], '1998;': [573, 994, 1052, 1086, 1635, 1803, 2383, 2475, 2551], ':': [574], '479-486Google': [575], '3.Speir': [577], 'Modali': [579], 'R.': [580, 613, 749, 753, 1244, 1268, 1287, 1305, 1353, 1372, 1671, 1852, 1875, 3247], 'Huang': [581, 3341], 'E.S.': [582, 722], 'Leon': [583], 'M.B.': [584], 'Shawl': [585], 'F.': [586, 842, 1124, 1281, 1366, 1649, 2150, 2939, 3199, 3413, 3626, 3746, 4018, 4221], 'Finkel': [587], 'T.': [588, 755, 760, 1283, 1313, 1368, 1555, 1565, 1567, 1675, 1748, 1840, 2359, 2378, 2470, 2546], 'Epstein': [589], 'S.E.': [590], 'Science.': [591, 4232], '1994;': [592, 955], '265:': [593], '391-394Crossref': [594], 'PubMed': [595, 620, 708, 737, 798, 858, 961, 997, 1015, 1055, 1089, 1140, 1258, 1299, 1323, 1384, 1434, 1482, 1609, 1665, 1684, 1753, 1783, 1806, 1834, 1865, 1886, 1943, 2166, 2364, 2386, 2478, 2532, 2554, 2955, 3215, 3261, 3361, 3429, 3642, 3762, 4034, 4236], 'Scopus': [596, 621, 709, 738, 799, 859, 998, 1016, 1056, 1141, 1259, 1300, 1324, 1385, 1435, 1610, 1666, 1685, 1754, 1807, 1835, 1866, 1887, 1944, 2167, 2365, 2387, 2479, 2533, 2555, 2956, 3216, 3262, 3362, 3430, 3643, 3763, 4035, 4237], '(701)': [597], '4.Almond': [600], 'P.S.': [601], 'Matas': [602], 'A.': [603, 687, 733, 1275, 1309, 1360, 1619, 1628, 1645, 1679], 'Gillingham': [604], 'K.': [605, 844, 1126, 1559, 1738, 1856, 2152, 2349, 2941, 3201, 3415, 3628, 3748, 4020, 4225], 'Dunn': [606], 'D.L.': [607], 'Payne': [608], 'W.D.': [609], 'Gores': [610], 'P.': [611, 681, 768, 838, 1120, 1234, 1264, 1315, 1349, 2146, 2935, 3195, 3237, 3409, 3622, 3742, 4014], 'Gruessner': [612], 'Najarian': [614], 'J.S.': [615], 'Transplant.': [616], '1993;': [617], '55:': [618], '752-757Crossref': [619], '(636)': [622], 'Scholar).': [624, 802, 862, 1019, 1059, 1091, 1144, 1327, 1388, 1438, 1484, 1576, 1688, 1757, 1890, 1947, 2170, 2390, 2482, 2558, 2959, 3219, 3365, 3433, 3646, 3766, 4038, 4240], 'development': [626, 830], 'vascular': [628, 828], 'involves': [630], 'many': [636], 'contributing': [637], 'factors,': [638], 'these,': [641], 'chemokines': [642, 971, 975, 1022, 1043, 1344], 'their': [644], 'receptors': [645, 668, 947, 1465, 1922], 'identified': [648, 1392], 'key': [650], 'mediators.': [651], 'encodes': [654], 'CXC': [656], '(UL146),': [658], 'potential': [660, 666], 'CC': [661, 974, 1021, 1042, 1343], '(UL128),': [663], 'four': [665], '(US27,': [669], 'US28,': [670, 2905], 'UL33,': [671], 'UL78)': [673], 'most': [676], 'characterized': [677], 'being': [678], '(5.Akter': [680], 'Cunningham': [682], 'C.': [683, 689, 834, 1116, 1270, 1307, 1355, 1654, 1656, 2142, 2931, 3191, 3405, 3618, 3738, 4010], 'McSharry': [684], 'B.P.': [685], 'Dolan': [686], 'Addison': [688], 'Dargan': [690], 'D.J.': [691, 716, 1924, 2370, 2462, 2513, 2538], 'Hassan-Walker': [692], 'A.F.': [693], 'Emery': [694], 'V.C.': [695], 'Griffiths': [696], 'P.D.': [697], 'Wilkinson': [698], 'G.W.': [699, 724], 'Davison': [700], 'A.J.': [701, 1626, 1643], 'J.': [702, 836, 952, 1084, 1118, 1247, 1273, 1288, 1318, 1358, 1373, 1423, 1568, 1603, 1633, 1659, 1744, 1777, 1823, 1860, 2144, 2355, 2382, 2474, 2550, 2933, 3193, 3250, 3348, 3355, 3407, 3620, 3740, 4012], 'Gen.': [703], 'Virol.': [704, 1085, 1319], '2003;': [705, 1291, 1320, 1376, 1426, 1681, 1862, 3358], '84:': [706], '1117-1122Crossref': [707], '(116)': [710], '6.Penfold': [713], 'Dairaghi': [715], 'Duke': [717], 'G.M.': [718, 1477], 'Saederup': [719], 'N.': [720, 1736, 1740, 1850, 2347, 2351], 'Mocarski': [721], 'Kemble': [723], 'Schall': [725, 1601], 'T.J.': [726, 1602], 'Proc.': [727], 'Natl.': [728], 'Acad.': [729], 'Sci.': [730, 1779], 'U.': [731], '1999;': [734, 850, 1132, 1572, 1662, 2158, 2947, 3207, 3421, 3634, 3754, 4026, 4233], '96:': [735], '9839-9844Crossref': [736], '(303)': [739], '7.Chee': [742], 'M.S.': [743, 785], 'Bankier': [744], 'A.T.': [745], 'Beck': [746], 'Bohni': [748], 'Browne': [750], 'C.M.': [751], 'Cerny': [752], 'Horsnell': [754], 'Hutchison': [756], 'III,': [757], 'C.A.': [758], 'Kouzarides': [759], 'Martignetti': [761], 'J.A.': [762, 848, 1130, 2156, 2945, 3205, 3338, 3419, 3632, 3752, 4024], 'Preddie': [763, 788], 'Satchwell': [765, 786], 'S.C.': [766, 787], 'Tomlinson': [767], 'Weston': [769, 790], 'K.M.': [770, 791], 'Barrell': [771, 792], 'B.G.': [772, 793], 'McDougall': [773], 'J.K.': [774], 'Cytomegaloviruses.': [775], 'Springer-Verlag': [776], 'New': [777, 780], 'York': [778], 'Inc.,': [779], 'York1990:': [781], '125-171Google': [782], '8.Chee': [784], 'Nature.': [794, 1749, 2360], '1990;': [795], '344:': [796], '774-777Crossref': [797], '(233)': [800], 'reported': [806, 2111], 'mediates': [809, 3611], 'may': [820, 2219], 'contribute': [821], 'viral': [823], 'dissemination': [824], 'and/or': [825, 1919, 2578, 2761, 2763, 3446], 'acceleration': [826], '(9.Streblow': [831, 1113, 2139, 2928, 3188, 3402, 3615, 3735, 4007], 'D.N.': [832, 1114, 2140, 2929, 3189, 3336, 3403, 3616, 3736, 4008], 'Söderberg-Nauclér': [833, 1115, 2141, 2930, 3190, 3404, 3617, 3737, 4009], 'Vieira': [835, 1117, 2143, 2932, 3192, 3406, 3619, 3739, 4011], 'Smith': [837, 1119, 2145, 2934, 3194, 3408, 3621, 3741, 4013], 'Wakabayashi': [839, 1121, 2147, 2936, 3196, 3410, 3623, 3743, 4015], 'Rutchi': [841, 1123, 2149, 2938, 3198, 3412, 3625, 3745, 4017], 'Mattison': [843, 1125, 2151, 2940, 3200, 3414, 3627, 3747, 4019], 'Altschuler': [845, 1127, 2153, 2942, 3202, 3416, 3629, 3749, 4021], 'Y.': [846, 1128, 1732, 1848, 2154, 2343, 2943, 3203, 3417, 3630, 3750, 4022, 4212], 'Nelson': [847, 1129, 2155, 2944, 3204, 3337, 3418, 3631, 3751, 4023], 'Cell.': [849, 1131, 2157, 2946, 3206, 3420, 3633, 3753, 4025], '99:': [851, 1133, 2159, 2948, 3208, 3422, 3635, 3755, 4027], '511-520Abstract': [852, 1134, 2160, 2949, 3209, 3423, 3636, 3756, 4028], 'Full': [853, 855, 958, 1135, 1137, 1253, 1255, 1294, 1296, 1379, 1381, 1429, 1431, 1829, 1831, 2161, 2163, 2950, 2952, 3210, 3212, 3256, 3258, 3424, 3426, 3637, 3639, 3757, 3759, 4029, 4031], 'Text': [854, 856, 959, 1136, 1138, 1254, 1256, 1295, 1297, 1380, 1382, 1430, 1432, 1830, 1832, 2162, 2164, 2951, 2953, 3211, 3213, 3257, 3259, 3425, 3427, 3638, 3640, 3758, 3760, 4030, 4032], 'PDF': [857, 960, 1139, 1257, 1298, 1383, 1433, 1833, 2165, 2954, 3214, 3260, 3428, 3641, 3761, 4033], '(350)': [860, 1142, 2168, 2957, 3217, 3431, 3644, 3764, 4036], 'monocyte': [868, 907], 'protein': [870, 909, 2071, 2093, 2106, 2640, 3166, 3922, 3948, 3957, 4293], 'extracellular': [871, 910, 4285], 'hemagglutinin': [879, 918], 'multiplicity': [880, 919, 2581], 'wild': [883, 922], 'type': [884, 923, 1519], 'regulated': [885, 924], 'secreted': [893, 932], 'acids)': [897, 936], '4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine': [898, 937], 'macrophage': [899, 938], 'contains': [942, 3270, 3324], 'homology': [943], 'CC-chemokine': [946], '(10.Gao': [948], 'Murphy': [950], 'P.M.': [951], 'Biol.': [953, 1248, 1289, 1374, 1424, 1661, 1824, 1939, 2528, 3251, 3357], 'Chem.': [954, 1249, 1290, 1375, 1425, 1825, 3252], '269:': [956], '28539-28542Abstract': [957], 'Scholar)': [963, 3265], 'binds': [965, 1032, 2073, 4247], 'broad': [968], 'spectrum': [969], 'including': [972, 1692, 2063], 'RANTES,': [976], 'MCP-1,': [977], 'MCP-3,': [978], 'MIP-1β': [980], 'CX3C': [983], 'Fractalkine/CX3CL1': [985], '(11.Kledal': [986, 1044], 'T.N.': [987, 1045, 1653], 'Rosenkilde': [988, 1046, 1413], 'M.M.': [989, 1047], 'Schwartz': [990, 1048, 1421], 'T.W.': [991, 1049, 1422], 'FEBS': [992, 1050], 'Lett.': [993, 1051], '441:': [995, 1053], '209-214Crossref': [996, 1054], '(169)': [999, 1057], '12.Kuhn': [1002], 'D.E.': [1003], 'Beall': [1004], 'C.J.': [1005], 'Kolattukudy': [1006], 'P.E.': [1007], 'Biochem.': [1008], 'Biophys.': [1009], 'Commun.': [1011], '1995;': [1012, 1479, 1750, 2361], '211:': [1013], '325-330Crossref': [1014], '(123)': [1017], 'That': [1020], 'fail': [1023], 'compete': [1025], 'out': [1026], 'Fractalkine': [1027, 1031, 1329], 'suggests': [1029], 'additional': [1034, 3146, 3946, 3979], 'unique': [1035], 'regions': [1036, 2229], 'compared': [1039], '293': [1061, 3313, 3380], 'cells,': [1062, 3372], 'ERK1/2': [1068], 'pathways': [1069, 1227, 1553], 'G-proteins': [1072, 1164, 1232, 1475, 1488], 'Gαi1': [1073], 'Gα16': [1075], '(13.Billstrom': [1076], 'M.A.': [1077], 'Johnson': [1078], 'G.L.': [1079], 'Avdi': [1080], 'N.J.': [1081], 'Worthen': [1082], 'G.S.': [1083], '72:': [1087], '5535-5544Crossref': [1088], 'demonstrated': [1095, 1713, 2826, 3604, 3990], 'requires': [1101, 3909], 'exogenously': [1106], 'added': [1107, 2963, 2998, 3090], 'or': [1109, 1999, 2121, 2766, 3138, 3303, 3503, 3506, 3545, 3776, 3787, 4251], 'endogenously': [1110], 'MCP-1': [1112], 'Induction': [1145], 'not': [1151, 1342, 3860, 3876, 3897], 'blocked': [1152, 2124, 3476, 3996], 'pertussis': [1156], 'toxin,': [1157], 'Gαi/o': [1159], 'inhibitor,': [1160], 'other': [1163, 1538, 2061, 2214, 4259], 'event.': [1169], 'fact,': [1171], 'we': [1172, 2109, 2172, 2225, 2500, 2899, 3692, 3708, 3989, 4040, 4070], 'recently': [1174], 'determined': [1175, 2227, 3062, 3161, 3694, 4121], 'couples': [1178], 'Gα12/13': [1180], 'signal': [1182, 2177], 'RhoA.': [1184], '2R.': [1185], 'Melnychuk,': [1186, 1189], 'unpublished': [1187, 1190], 'results.2R.': [1188], 'results.': [1191], 'manner': [1198, 3652], 'required': [1201, 2133, 2191, 2234, 4065], 'exhibit': [1212], 'constitutive': [1213, 1346, 3902], 'COS-7': [1216], 'cells': [1217, 1770, 2004, 2138, 2298, 2392, 2573, 2590, 2740, 2756, 2776, 2961, 2984, 3058, 3069, 3314, 3381, 3457, 3495, 3560, 3585, 3770, 3859, 3881], 'fibroblasts': [1220, 1718, 2309, 3435], 'both': [1222, 2884], 'NF-κB': [1223], 'phospholipase': [1225], 'C': [1226], 'via': [1228], 'Gq/11': [1231], '(14.Casarosa': [1233, 3236], 'Bakker': [1235, 3238], 'R.A.': [1236, 3239], 'Verzijl': [1237, 3240], 'D.': [1238, 1311, 1730, 1928, 2341, 2372, 2464, 2517, 2540, 3241, 3340], 'Navis': [1239, 3242], 'Timmerman': [1241, 1276, 1361, 3244], 'H.': [1242, 1277, 1362, 1563, 1598, 1816, 1822, 1842, 1858, 3245, 4223], 'Leurs': [1243, 1286, 1371, 1417, 3246], 'Smit': [1245, 1284, 1369, 1415, 3248], 'M.J.': [1246, 1285, 1370, 1416, 1881, 3249], '2001;': [1250, 3253], '276:': [1251, 3254], '1133-1137Abstract': [1252, 3255], '(198)': [1260, 3263], '15.Casarosa': [1263], 'Menge': [1265, 1350], 'W.M.': [1266, 1351], 'Minisini': [1267, 1352], 'Otto': [1269, 1354], 'van': [1271, 1356], 'Heteren': [1272, 1357], 'Jongejan': [1274, 1359], 'Moepps': [1278, 1316, 1363], 'B.': [1279, 1317, 1364, 1820], 'Kirchhoff': [1280, 1365], 'Mertens': [1282, 1312, 1367], '278:': [1292, 1377, 1427], '5172-5178Abstract': [1293, 1378], '(77)': [1301, 1386, 1836], '16.Minisini': [1304], 'Tulone': [1306], 'Luske': [1308], 'Michel': [1310], 'Gierschik': [1314], '77:': [1321], '4489-4501Crossref': [1322], '(54)': [1325], 'well': [1334, 1402, 2967, 3002, 3060], 'inverse': [1338], 'agonist': [1339], '(VUF2274)': [1340], 'but': [1341], 'antagonized': [1345], '(15.Casarosa': [1348], 'Sequences': [1389], 'cytoplasmic': [1396, 1984], 'domain': [1397, 1898, 1952, 1960, 1978, 1985, 2067], 'mediate': [1399, 2198], 'recycling': [1404], 'from': [1405, 1504, 1720, 2414, 2427, 2435, 2443, 2451, 2509], 'plasma': [1407], 'membrane': [1408], '(17.Waldhoer': [1409], 'Casarosa': [1411], 'P': [1412], 'M.M': [1414], 'R': [1418], 'Whistler': [1419], '19473-19482Abstract': [1428], '(92)': [1436], 'Together': [1439], 'these': [1440, 2137, 3706], 'data': [1441], 'highlight': [1442], 'fact': [1444], 'there': [1446], 'activities': [1449], 'type-specific': [1452], 'effects': [1453], 'occurring': [1454], 'signaling.': [1457, 4058], 'Lymphocyte': [1458], 'induced': [1460, 3579], 'ligation': [1462, 3697], 'generally': [1467], 'mediated': [1468, 4255], 'Gαi': [1471], 'class': [1472], 'heterotrimeric': [1474], '(18.Bokoch': [1476], 'Blood.': [1478], '86:': [1480], '1649-1660Crossref': [1481], 'Upon': [1485], 'GPCR': [1486], 'stimulation,': [1487, 2033], 'bind': [1489, 2049, 4303], 'directly': [1490, 4248], 'receptor,': [1493], 'exchanging': [1494], 'GDP': [1495], 'GTP,': [1497], 'causing': [1498], 'dissociation': [1499], 'Gα': [1502, 1513, 1521, 1544], 'subunit': [1503, 1514, 1522], 'Gβγ': [1506, 1533], 'Downstream': [1508], 'effectors': [1509], 'activated': [1512], 'specific': [1516], 'each': [1518, 3052, 3925], 'can': [1524, 1547, 2176], 'include': [1525, 1548], 'Ca+2': [1526], 'influx,': [1527], 'cAMP,': [1528], 'phosphatidylinositol': [1530], 'phosphate.': [1531], 'heterodimer': [1534], 'cascades': [1537], 'those': [1540, 4196], 'stimulated': [1541, 2592, 2778], 'subunit,': [1545], '(PTK)': [1552], '(19.Inagami': [1554], 'Eguchi': [1556], 'Numaguchi': [1558], 'Motley': [1560], 'E.D.': [1561], 'Tang': [1562], 'Matsumoto': [1564], 'Yamakawa': [1566], 'Am.': [1569], 'Soc.': [1570], 'Nephrol.': [1571], '10:': [1573], '57-61PubMed': [1574], 'For': [1577, 2288, 3107, 3705], 'example': [1578], 'ligand': [1579, 3910, 4206], 'CCR2,': [1582], 'CCR5,': [1583], 'CXCR1/2': [1585], 'induce': [1586], 'cellular': [1587, 1703, 1710, 2126, 2860, 3576, 3679, 3796, 4100, 4282], 'PTK': [1591, 2118, 2130, 3657, 3663, 3673], 'pathway': [1592], '(20.Bacon': [1593], 'K.B.': [1594], 'Szabo': [1595], 'M.C.': [1596], 'Yssel': [1597], 'Bolen': [1599], 'J.B.': [1600], 'Exp.': [1604], '1996;': [1606, 1780], '184:': [1607], '873-882Crossref': [1608], '(132)': [1611], '21.Mellado': [1614], 'Rodriguez-Frade': [1616], 'J.M.': [1617, 1641], 'Aragay': [1618], 'del': [1620], 'Real': [1621], 'G.': [1622], 'Martin': [1623, 1644], 'A.M.': [1624], 'Vila-Coro': [1625], 'Serrano': [1627], 'Mayor': [1629], 'F.J.': [1630], 'Martinez': [1631], 'A.C.': [1632], 'Immunol.': [1634], '161:': [1636], '805-813PubMed': [1637], '22.Rodriguez-Frade': [1640], 'Vila-Corao': [1642], 'Nieto': [1646], 'Sanchez-Madrid': [1648], 'Proudfoot': [1650], 'A.E.I.': [1651], 'Wells': [1652], 'Martinez-A': [1655], 'Mellado': [1657], 'Cell': [1660, 1778, 1938, 2261, 2428, 2527, 3356], '144:': [1663], '755-765Crossref': [1664], '(109)': [1667], '23.Feniger-Barish': [1670], 'Yron': [1672], 'I.': [1673], 'Meshel': [1674], 'Matityahu': [1676], 'Ben-Baruch': [1678], 'Biochemistry.': [1680], '42:': [1682], '2874-2886Crossref': [1683], '(49)': [1686], 'Activation': [1689, 3595], 'PTK(s)': [1691], 'considered': [1700], 'central': [1701, 1896, 1958], 'importance': [1706, 3676], 'was': [1712, 1763, 2274, 2450, 2458, 2632, 2707, 2808, 2825, 2862, 2997, 3061, 3089, 3160, 3448, 3536, 3654, 3798, 3837, 3845, 3949, 3958, 4064], 'inability': [1716], 'isolated': [1719], 'FAK–/–': [1721, 2308, 2391], 'mice': [1722], 'migrate': [1724], 'response': [1726], 'stimuli': [1728], '(24.Ilic': [1729, 2340], 'Furuta': [1731, 2342], 'Kanazawa': [1733, 2344], 'Takeda': [1735, 2346], 'Sobue': [1737, 2348], 'Nakatsuji': [1739, 2350], 'Nomura': [1741, 2352], 'Fujimoto': [1743, 2354], 'Okada': [1745, 2356], 'Yamamoto': [1747, 2358], '377:': [1751, 2362], '539-544Crossref': [1752, 2363], '(1576)': [1755, 2366], 'overexpression': [1760], 'enhance': [1766], 'movement': [1767], 'CHO': [1769], '(25.Cary': [1771], 'L.A.': [1772], 'Chang': [1773], 'J.F.': [1774], 'Guan': [1775], '109:': [1781], '1787-1794Crossref': [1782], 'Scholar),': [1785], 'highly': [1787, 3959], 'invasive': [1788], 'tumors': [1789], 'characteristically': [1790], 'heightened': [1792], 'levels': [1793, 3167, 3923, 4182], '(26.Kornberg': [1799], 'L.J.': [1800], 'Head': [1801], 'Neck.': [1802], '20:': [1804], '745-752Crossref': [1805], '(148)': [1808], '27.Nurcombe': [1811], 'V.': [1812], 'Smart': [1813], 'C.E.': [1814], 'Chipperfield': [1815], 'Cool': [1817], 'S.M.': [1818], 'Boilly': [1819], 'Hondermarck': [1821], '2000;': [1826, 1940, 2529], '275:': [1827], '30009-30018Abstract': [1828], '28.Miyazaki': [1839], 'Kato': [1841], 'Nakajima': [1843], 'Sohda': [1845], 'Fukai': [1847], 'Masuda': [1849], 'Manda': [1851], 'Fukuchi': [1853], 'Tsukada': [1855], 'Kuwano': [1857], 'Br.': [1859], 'Cancer.': [1861, 1882], '89:': [1863], '140-145Crossref': [1864], '(162)': [1867], '29.Schneider': [1870], 'G.B.': [1871], 'Kurago': [1872], 'Z.': [1873], 'Zaharias': [1874], 'Gruman': [1876], 'L.M.': [1877, 4208], 'Schaller': [1878], 'M.D.': [1879], 'Hendrix': [1880], '95:': [1884], '2508-2515Crossref': [1885], '(61)': [1888], 'comprised': [1893, 1963], 'flanked': [1899], 'one': [1901], 'side': [1902], 'an': [1904, 2043, 2495, 3145, 3225, 3325, 3589, 3900, 3945, 4053], 'N-terminal': [1905, 3226], 'FERM': [1906], '(erythrocyte': [1907], 'band': [1908], '4.1-ezrin-radixin-moesin)': [1909], 'domain,': [1910], 'linking': [1915], 'integrins': [1918], 'growth': [1920, 2000], 'factor': [1921, 2001, 2087], '(30.Sieg': [1923, 2512], 'Hauck': [1925, 2514, 3333], 'C.R.': [1926, 2515, 3334], 'Ilic': [1927, 2371, 2463, 2516, 2539, 3339], 'Klingbeil': [1929, 2518], 'C.K.': [1930, 2519], 'Schaefer': [1931, 2520], 'Damsky': [1933, 2375, 2467, 2522, 2543], 'C.H.': [1934, 2376, 2468, 2523, 2544], 'Schlaepfer': [1935, 2379, 2471, 2524, 2547, 3353], 'D.D.': [1936, 2380, 2472, 2525, 2548, 3354], 'Nat.': [1937, 2526], '2:': [1941, 2530], '249-256Crossref': [1942, 2531], '(1044)': [1945, 2534], 'targeting': [1951], 'located': [1954], 'C-terminal': [1955], 'multiple': [1965, 4292], 'protein-protein': [1966], 'interaction': [1967, 4253], 'motifs.': [1968], 'paxillin': [1972], 'talin': [1974], 'FAK-FAT': [1977], 'facilitates': [1979, 3967], 'linkage': [1981], 'integrins,': [1987], 'targets': [1989], 'adhesions.': [1993], 'tyrosine': [1995], 'phosphorylation': [1996], 'integrin': [1998], 'stimulation': [2002, 4164], 'enhanced': [2006], 'its': [2008], 'Src-family': [2011, 2047], 'PTKs.': [2012], 'leads': [2014], 'multiprotein': [2020], 'complex': [2022, 2081, 2499, 3827, 3853, 3869, 4157], 'serves': [2026], 'scaffold.': [2029], 'Mechanistically,': [2030], 'autophosphorylates': [2035], 'at': [2036, 2052, 2059, 2580, 2600, 2714, 2769, 2786, 2980, 2994, 3026, 3035, 3042, 3140, 3471, 3519, 3553, 3784, 3839, 4291], 'Tyr-397,': [2037, 2053], 'resulting': [2038], 'SH2': [2044, 2066], 'docking': [2045], 'site.': [2046], 'PTKs': [2048], 'become': [2054], 'activated,': [2055], 'trans-phosphorylate': [2057], 'several': [2060], 'tyrosines': [2062], 'Tyr-925.': [2064], 'adaptor': [2070, 4304], 'Grb2': [2072, 2807], 'Tyr-925': [2076], 'forms': [2078], 'includes': [2083, 3978], 'nucleotide': [2085], 'exchange': [2086], 'Sos': [2088], 'small': [2091], 'GTP-binding': [2092], 'Ras.': [2094], 'sequence': [2096], 'events': [2098], 'contributes': [2099], 'subsequent': [2102], 'ERK2/mitogen-activated': [2105], 'kinase.': [2107], 'Previously,': [2108], 'genistein': [2120, 4003], 'herbimycin': [2122, 4005], 'A': [2123, 4006], 'US28-induced': [2125, 2236], 'migration,': [2127, 3691, 4069, 4101], 'Here': [2171], 'ability': [2194, 4299], 'manner,': [2209], 'contrary': [2212], 'reports': [2215], 'be': [2220], 'constitutively': [2221], 'active.': [2222], 'play': [2247], 'integral': [2248], 'roles': [2249], 'ligand-dependent,': [2251], 'induction': [2257], 'Lines': [2262], 'Antibodies—The': [2264], 'life-extended': [2265], 'pulmonary': [2267], 'artery': [2268], 'line,': [2272], 'PAT12': [2273], 'maintained': [2275, 2311], 'Medium': [2277], '199': [2278], 'supplemented': [2279, 2321], '20%': [2281], 'fetal': [2282, 2324, 3486], 'calf': [2283, 2325, 3487], 'serum': [2284, 2457, 2638, 3488], 'penicillin-streptomycin-l-glutamine': [2286], '(Invitrogen).': [2287], 'vitro': [2292, 2503, 3711, 3807], 'experiments': [2294, 2396], 'described': [2295, 2339, 2460, 2895, 2927, 3163, 3187, 3401, 3454, 3734], 'below': [2296], 'PAT1': [2297, 2559, 3726, 3769, 3858, 3880], 'were': [2299, 2310, 2393, 2412, 2426, 2434, 2442, 2561, 2574, 2591, 2612, 2648, 2726, 2741, 2757, 2777, 2799, 2812, 2892, 2909, 2923, 2962, 2988, 3010, 3024, 3039, 3049, 3083, 3118, 3152, 3168, 3185, 3229, 3299, 3368, 3377, 3389, 3436, 3458, 3496, 3523, 3561, 3586, 3720, 3771, 3803], 'utilized': [2300], 'between': [2301, 2397, 4168], 'passage': [2302, 2398], '5': [2303, 2399, 3829, 4171], '30': [2305, 2794], 'post-telomerization.': [2306], 'Mouse': [2307], 'gelatin-coated': [2313, 3440], 'culture': [2314, 2565, 2745], 'dishes': [2315, 2566, 2746], "Dulbecco's": [2317], 'modified': [2318], "Eagle's": [2319], 'medium': [2320], '10%': [2323, 2670, 2692, 3485], 'serum,': [2326], 'penicillin-streptomycin-l-glutamine,': [2327], 'nonessential': [2328], '(Cellgro),': [2331], 'G418': [2333], '(Sigma;': [2334], '500': [2335], 'μg/ml)': [2336], '31.Sieg': [2369, 2537], 'Jones': [2373, 2465, 2541], 'K.C.': [2374, 2466, 2542], 'Hunter': [2377, 2469, 2545], 'EMBO': [2381, 2473, 2549], '17:': [2384, 2476, 2552], '5933-5947Crossref': [2385, 2477, 2553], '(286)': [2388, 2480, 2556], '15.': [2401], 'Anti-Grb2': [2402], '(C-7),': [2403], 'anti-c-Src,': [2404], 'anti-phosphotyrosine': [2405], '(PY99),': [2406], 'anti-HA': [2408], '(F-7)': [2409], 'monoclonal': [2410, 2448], 'antibodies': [2411, 2419, 2432, 2441, 2818, 2847, 2876, 2914, 3499, 3915, 3929, 4131, 4145], 'purchased': [2413], 'Santa': [2415], 'Cruz': [2416], 'Biotechnology.': [2417], 'Phospho-specific': [2418], 'ERK2': [2421, 2425], '(Thr-202/Tyr-204)': [2422], 'total': [2424, 2630, 2806, 2855, 4097], 'Signaling': [2429], 'Technologies.': [2430], 'Paxillin': [2431], '(5H11)': [2433], 'Upstate': [2436], 'Biotechnologies,': [2437], 'anti-c-Myc': [2439], 'tag': [2440, 2881, 3228], 'Covance.': [2444], 'anti-FLAG': [2446], '(M2)': [2447], 'antibody': [2449, 3535, 3549], 'Sigma': [2452], 'anti-FAK': [2455, 2636], 'polyclonal': [2456, 2637, 2913], '(31.Sieg': [2461], 'Vitro': [2485], 'Kinase': [2486], 'Assays—To': [2487], 'determine': [2488, 3098, 3682, 4060], 'whether': [2489, 3683, 3695, 4061, 4122], 'active': [2496], 'performed': [2501, 2924, 3709, 4071], 'assays': [2505, 2922, 3713, 3809, 4073, 4129], 'immunoprecipitated': [2507, 2633, 3926], 'SMCs': [2560], 'plated': [2562, 2742], '10-cm': [2564, 2744], 'serum-starved': [2568, 2748, 2989], '24': [2570], 'h.': [2571, 2992, 3005, 3148], 'co-infected': [2575, 2758], 'Ad-US28': [2577, 2762], 'Ad-Trans': [2579, 2760, 3131, 3394], '(m.o.i.)': [2584], '500.': [2585], 'After': [2586, 2772, 3006], '16': [2587, 2773], 'h': [2588, 2751, 2774, 3028, 3092, 3126, 3518, 3552], '(50': [2595, 2662], 'ng/ml)': [2596, 2782], 'then': [2598, 2697, 2718, 2784], 'harvested': [2599, 2785, 3783], 'times': [2601, 2658, 2676, 2787, 3526], '0': [2602, 2788], '(unstimulated),': [2603, 2789], '5,': [2604, 2790, 3785], '10,': [2605, 2791, 3786], '15': [2607, 2712, 3788, 3848], 'min': [2608, 2713, 2795, 3470, 3789, 3830, 4162, 4185], 'post-ligand': [2609, 2796], 'addition.': [2610, 2797], 'Cells': [2611, 2798, 2987, 3018, 3522], 'lysed': [2613, 2800], 'radioimmune': [2615, 2653, 2802], 'precipitation': [2616, 2654, 2803], 'assay': [2617, 2655], 'buffer': [2618, 2661, 2679, 2701, 2832], 'containing': [2619, 2833], '1%': [2620, 2623, 2668, 2839, 2842, 3466], 'Triton': [2621, 3479], 'X-100,': [2622], 'sodium': [2624, 3491], 'deoxycholate,': [2625], '0.1%': [2627, 3439, 3490], 'SDS,': [2628, 2840], 'using': [2634, 2817, 2846, 2875, 3030, 3450, 3566, 3728, 3914, 4130], 'rabbit': [2635, 2912], 'A/G-conjugated': [2641], 'agarose': [2642], 'beads': [2643], '(Santa': [2644], 'Cruz).': [2645], 'Precipitation': [2646], 'reactions': [2647, 2889], 'washed': [2649, 3011, 3459, 3524], '1': [2650, 2981, 3517, 3551], 'time': [2651, 3558, 3774, 3883], 'buffer,': [2656, 2805], '2': [2657, 2675, 3004, 3125, 3147], 'HNTG': [2660], 'mm': [2663, 2666, 2681, 2684, 2687, 2690], 'HEPES,': [2664, 2682], '150': [2665, 2689], 'NaCl,': [2667, 2691], 'Triton,': [2669], 'glycerol,': [2671, 2693], 'pH': [2672, 2694, 2837], '7.4),': [2673], '(20': [2680], '10': [2683, 2686, 2996, 3469, 3840, 4184], 'MgCl2,': [2685], 'MnCl2,': [2688], '7.4)': [2695], 'resuspended': [2698], 'plus': [2702], '[γ-32P]ATP.': [2703], 'reaction': [2706], 'allowed': [2708], 'proceed': [2710], '32': [2715], '°C': [2716], 'analyzed': [2719, 2727, 2813], 'SDS-PAGE': [2721, 3813], 'autoradiography.': [2723, 3815], 'blots': [2725, 2830, 2908], 'Western': [2729, 2815, 3171, 3912], 'blotting': [2730, 2816, 2866, 3172, 3913], 'Src.': [2737, 4118], 'Immunoprecipitation': [2738], 'Reactions—FAK–/–': [2739], '6': [2750], 'upon': [2752, 4151], '75%': [2753], 'confluence.': [2754], 'Ad-FAK': [2764, 3133], 'WT': [2765], 'mutants': [2768], 'm.o.i.': [2770, 2995, 3141, 3180], '50.': [2771], '(40': [2781], '15,': [2792], 'lysis': [2804], 'immunoprecipitated,': [2809, 3799], 'samples': [2811, 3802], 'directed': [2819, 2848, 2877, 2915, 3916, 3930, 4132, 4146], 'against': [2820, 2849, 2878, 2916, 3500, 3917, 3931, 4133, 4147], 'Tyr(P).': [2821], 'Co-precipitation': [2822], 'FAK-HA': [2824, 3504], 'stripping': [2828], '0.1': [2834], 'm': [2835], 'Tris,': [2836], '6.8,': [2838], '2-mercaptoethanol': [2843], 'staining': [2845], 'HA.': [2850], 'Before': [2851], 'immune-complex': [2852], 'reactions,': [2853], '50': [2857, 3779], 'μl': [2858], 'lysate': [2861], 'assayed': [2863], 'SDS-PAGE/Western': [2865], 'input': [2871], 'HA': [2880, 3227], 'present': [2882], 'recombinant': [2885], 'proteins.': [2886], 'co-immunoprecipitation': [2888, 4128], 'done': [2893, 3040], 'above': [2896], 'except': [2897], 'FLAG-tagged': [2902], 'version': [2903, 4137], 'probed': [2910], 'c-Src.': [2917], 'Migration': [2919, 3647], 'Assay—Cell': [2920], 'Briefly,': [2960], 'upper': [2966, 3001], 'Transwell': [2970, 3151], '(12-mm': [2971], 'diameter,': [2972], '3.0-μm': [2973], 'pore': [2974], 'size,': [2975], 'Costar': [2976], 'Corning,': [2977], 'Cambridge,': [2978], 'MA)': [2979], '×': [2982], '105': [2983], 'per': [2985, 3059, 3070, 3078], 'well.': [2986, 3053, 3079], '16–24': [2991], 'inserts': [3009], 'transferred': [3013, 3153], 'fresh': [3015, 3155], '12-well': [3016, 3156], 'plates.': [3017, 3157], 'migrating': [3019], 'lower': [3022], 'chamber': [3023, 3442], 'counted': [3025], '48–72': [3027], 'post-infection': [3029], 'Nikon': [3032, 3591], 'TE300': [3033], 'microscope': [3034], 'magnification': [3036], '10×.': [3037], 'Experiments': [3038], 'least': [3043], 'triplicate': [3044], 'wells.': [3045], 'Ten': [3046], 'random': [3047], 'fields': [3048, 3077], 'read': [3050], 'average': [3055, 3066], 'number': [3056, 3067, 3075], 'multiplying': [3064], '10×': [3071], 'field': [3072], 'Mean': [3080], 'S.D.': [3082], 'calculated.': [3084], '(1–25': [3086], 'μm;': [3087], 'Calbiochem)': [3088], '4': [3091], 'HCMV-US28-mediated': [3104], 'studies': [3110], 'involving': [3111], 'adenovirus': [3115, 3286, 3320, 3327, 3452], 'constructs,': [3116], 'infected': [3119], '(m.o.i.': [3122], '10)': [3123], 'followed': [3127, 3279], 'co-infection': [3129, 3392], '(WT,': [3134, 3305], 'NT,': [3135, 3306], 'Phe-397,': [3136], 'Arg-454,': [3137], 'Pro-)': [3139], '1000': [3143], 'Subsequently,': [3149], 'Cellular': [3158], 'above.': [3164, 3455], 'Recombinant': [3165, 3297, 3366], 'monitored': [3169], 'equalized': [3174], 'adjusting': [3176], 'adenoviral': [3178], 'vector': [3179, 3269], 'Adenovirus': [3181, 3220, 3718], 'Construction—Adenoviruses': [3182], 'expressing': [3183, 3222, 3315, 3395, 3861, 4090], 'US28-FLAG': [3184, 3501, 4148], 'vectors': [3221, 3453, 3719], 'constructed': [3230], 'subcloning': [3232], 'DNA': [3234, 3321], 'fragment': [3235], 'into': [3266], 'pAdTet7.': [3267], 'tet-responsive': [3272], 'enhancer': [3273], 'within': [3274], 'minimal': [3276], 'CMV': [3277], 'promoter': [3278], 'SV40': [3282], 'late': [3283], 'poly(A)': [3284], 'cassette,': [3285], 'E1A,': [3287], 'single': [3290], 'loxP': [3291], 'site': [3292], 'increase': [3294], 'recombination': [3295], 'frequency.': [3296], 'adenoviruses': [3298, 3367], 'produced': [3300], 'pAdUS28-HA': [3302], 'pAdFAK': [3304], 'Pro,': [3307], 'R454K,': [3308], 'Phe-397)': [3309], 'construct': [3310], 'co-transfection': [3311], 'Cre': [3317], 'recombinase': [3318], '(Ad5-ψ5)': [3322], 'E1A/E3-deleted': [3326], 'genome': [3328], '(32.Hsia': [3329], 'D.A.': [3330, 3352], 'Mitra': [3331], 'S.K.': [3332], 'Streblow': [3335], 'Li': [3343], 'Nemerow': [3345], 'G.R.': [3346], 'Leng': [3347], 'Spencer': [3349], 'K.S.': [3350], 'Cheresh': [3351], '160:': [3359], '753-767Crossref': [3360], '(454)': [3363], 'expanded': [3369], '293-Cre': [3371], 'bulk': [3375], 'stocks': [3376], 'titered': [3378], 'limiting': [3383], 'dilution.': [3384], 'driven': [3390], 'Tet-off': [3397], 'transactivator': [3398], 'Immunocytochemistry—FAK–/–': [3434], 'grown': [3437], '4-well': [3441], 'slides': [3443], '(Nalge-Nunc).': [3444], 'phosphate-buffered': [3461, 3465, 3482, 3528], 'saline,': [3462, 3529], 'fixed': [3463], 'paraformaldehyde': [3467], 'room': [3472, 3520, 3554], 'temperature,': [3473], 'permeabilized,': [3474], '0.3%': [3478], 'X-100': [3480], 'saline': [3483], 'azide.': [3492], 'Thereafter,': [3493], 'incubated': [3497], 'epitope': [3502, 3505, 3508], 'FAK-c-Myc': [3507], '(FAK-NT': [3509], 'mutant': [3510], 'only)': [3511], '1:200': [3514], 'dilution': [3515], 'temperature.': [3521, 3555], 'three': [3525], 'detected': [3537], 'fluorescein': [3540], 'isothiocyanate': [3541], 'tetramethyl-conjugated': [3542], 'goat': [3543, 3547], 'anti-mouse': [3544], 'rhodamine-conjugated': [3546], 'anti-rabbit': [3548], 'At': [3556], 'stained': [3563], 'actin': [3565, 3577], 'phalloidin': [3567], '(Molecular': [3568], 'Probes,': [3569], 'Eugene,': [3570], 'OR)': [3571], 'monitor': [3573], 'alterations': [3574], 'cytoskeleton': [3578], 'Fluorescence-positive': [3584], 'visualized': [3587], 'inverted': [3590], 'fluorescent': [3592], 'microscope.': [3593], 'Is': [3600], 'Ligand-dependent—We': [3601], 'HCMV-encoded': [3607], 'occurred': [3648, 4103], 'inhibitors,': [3658], 'facilitating': [3678], 'To': [3681, 4059], 'first': [3693], 'promoted': [3700, 3820], 'experiments,': [3707], 'immunoprecipitation': [3716], 'reactions.': [3717], 'express': [3723], 'HCMV-US28': [3724], 'methods': [3729], 'Serum-starved': [3767], 'US28-expressing': [3768, 3879], 'untreated': [3772], '(0': [3773, 3882], 'point)': [3775, 3884], 'treated': [3777], 'ng/ml': [3780], 'addition': [3792, 4153, 4204], 'ligand.': [3794], 'Total': [3795], 'subjected': [3804], 'examined': [3811, 4110], 'post-addition': [3831], 'ligand,': [3833], 'maximal': [3838, 4167], 'min.': [3841, 4172], 'min,': [3849], 'transient': [3855], '(Fig.': [3856, 3942, 4186], '1).': [3857, 3943], 'failed': [3863, 3885], 'promote': [3865], '(data': [3875], 'shown).': [3877], 'Untreated': [3878], 'activate': [3887], 'event': [3895], 'due': [3898], 'inherent': [3901], 'property': [3904], 'but,': [3907], 'rather,': [3908], 'binding.': [3911], 'showed': [3919], 'equal': [3920], 'sample,': [3927], 'confirmed': [3933], '∼47-kDa': [3947], 'co-immunoprecipitated': [3950], 'phosphorylated,': [3960], 'molecules.': [3981], 'Forms': [3983], 'Protein': [3985], 'Complex': [3986], 'Src—Previously': [3988], 'pan-PTK': [4001], 'Above': [4039], 'show': [4041], 'important': [4054], 'US28/FAK': [4057], 'increasing': [4078], 'concentrations': [4079], 'PP2.': [4081], 'As': [4082, 4140], 'Fig.': [4085, 4143], '2A,': [4086], 'resulted': [4094], 'near': [4096, 4180], 'inhibition': [4098], 'dose-dependent': [4106], 'next': [4109, 4120], 'mechanism': [4112], 'complexes': [4124], 'FLAG': [4135], 'epitope-tagged': [4136], 'US28.': [4139], '2B,': [4144], 'co-precipitated': [4149], 'RANTES.': [4155], 'formed': [4159], '2.5': [4161, 4169], 'returns': [4178], 'background': [4181], '2B).': [4187], 'kinetics': [4189], 'Src/US28': [4191], 'similar': [4194], 'observed': [4197], 'Src/β2-adrenergic': [4199], '(33.Luttrell': [4207], 'Ferguson': [4209], 'S.S.': [4210], 'Daaka': [4211], 'Miller': [4213], 'W.E.': [4214], 'Maudsley': [4215], 'Della': [4217], 'Rocca': [4218], 'G.J.': [4219], 'Lin': [4220], 'Kawakatsu': [4222], 'Owada': [4224], 'Luttrell': [4226], 'D.K.': [4227], 'Caron': [4228], 'M.G.': [4229], 'Lefkowitz': [4230], 'R.J.': [4231], '283:': [4234], '655-661Crossref': [4235], '(1234)': [4238], 'suggest': [4243], 'proteins': [4260, 4305], 'like': [4261], 'β-arrestin,': [4262], 'β2-adrenergic': [4267], 'receptor.': [4268], 'Mediates': [4270], 'Association': [4272], 'Adaptor': [4276], 'Proteins': [4277], 'Ligand-dependent': [4280], 'Manner—Upon': [4281], 'matrix': [4286], 'proteins,': [4287], 'phosphorylates': [4289], 'sites': [4295], 'increases': [4297], 'includ': [4306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014592511', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2025-01-12T02:34:27.514939', 'created_date': '2016-06-24'}
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