Publication Information

{'id': 'https://openalex.org/W2014455946', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-3576', 'title': 'Abstract 3576: USP22 modulates AR activity to critically regulate prostate cancer progression.', 'display_name': 'Abstract 3576: USP22 modulates AR activity to critically regulate prostate cancer progression.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2014455946', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-3576', 'mag': '2014455946'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-3576', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030878951', 'display_name': 'Randy S. Schrecengost', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Randy Schrecengost', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020145952', 'display_name': 'Jeffry L. Dean', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffry Dean', 'raw_affiliation_strings': ['2Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '2Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084896230', 'display_name': 'Tim Stanek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tim Stanek', 'raw_affiliation_strings': ['2Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '2Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074384753', 'display_name': 'Ruth Birbe', 'orcid': 'https://orcid.org/0000-0002-0651-2360'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ruth Birbe', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077295537', 'display_name': 'Jessica Hicks', 'orcid': 'https://orcid.org/0000-0001-7885-3319'}, 'institutions': [{'id': 'https://openalex.org/I6059380', 'display_name': 'University of Baltimore', 'ror': 'https://ror.org/024gw2733', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I6059380']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessica Hicks', 'raw_affiliation_strings': ['3Johns Hopkins University, Baltimore, MD;'], 'affiliations': [{'raw_affiliation_string': '3Johns Hopkins University, Baltimore, MD;', 'institution_ids': ['https://openalex.org/I6059380', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085775392', 'display_name': 'Tapio Visakorpi', 'orcid': 'https://orcid.org/0000-0002-5004-0364'}, 'institutions': [{'id': 'https://openalex.org/I166825849', 'display_name': 'Tampere University', 'ror': 'https://ror.org/033003e23', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I166825849']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Tapio Visakorpi', 'raw_affiliation_strings': ['4Institute of Biomedical Technology and BioMediTech, University of Tampere, Tampere, Finland.'], 'affiliations': [{'raw_affiliation_string': '4Institute of Biomedical Technology and BioMediTech, University of Tampere, Tampere, Finland.', 'institution_ids': ['https://openalex.org/I166825849', 'https://openalex.org/I166825849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083333223', 'display_name': 'Angelo M. De Marzo', 'orcid': 'https://orcid.org/0000-0003-4847-5307'}, 'institutions': [{'id': 'https://openalex.org/I6059380', 'display_name': 'University of Baltimore', 'ror': 'https://ror.org/024gw2733', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I6059380']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Angelo DeMarzo', 'raw_affiliation_strings': ['3Johns Hopkins University, Baltimore, MD;'], 'affiliations': [{'raw_affiliation_string': '3Johns Hopkins University, Baltimore, MD;', 'institution_ids': ['https://openalex.org/I6059380', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002991984', 'display_name': 'Steven B. McMahon', 'orcid': 'https://orcid.org/0000-0002-3405-1768'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steve McMahon', 'raw_affiliation_strings': ['1Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '1Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042472942', 'display_name': 'Karen E. Knudsen', 'orcid': 'https://orcid.org/0000-0002-1301-890X'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karen Knudsen', 'raw_affiliation_strings': ['2Thomas Jefferson University, Philadelphia, PA;'], 'affiliations': [{'raw_affiliation_string': '2Thomas Jefferson University, Philadelphia, PA;', 'institution_ids': ['https://openalex.org/I149251103']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '73', 'issue': '8_Supplement', 'first_page': '3576', 'last_page': '3576'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9745, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9588, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.70014656}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.45620844}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7917305}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.70014656}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6997541}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.68204576}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.63279706}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5551649}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.49149883}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4642817}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.45620844}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.43376106}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3097887}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29151022}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.26296142}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.22788256}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17664415}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09852427}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.0689103}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-3576', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.74, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4380992933', 'https://openalex.org/W4320492283', 'https://openalex.org/W4309090929', 'https://openalex.org/W4214695225', 'https://openalex.org/W3197607994', 'https://openalex.org/W3020059968', 'https://openalex.org/W2783284266', 'https://openalex.org/W2592007767', 'https://openalex.org/W2064085750', 'https://openalex.org/W2026862129'], 'abstract_inverted_index': {'Abstract': [0], 'Recently,': [1], 'the': [2, 14, 39, 186, 242, 264, 358, 363], 'deubiquitylase': [3], 'Ubiquitin-specific': [4], 'protease': [5], '22': [6], '(USP22)': [7], 'was': [8], 'identified': [9, 127], 'as': [10, 85, 129, 200, 316], 'a': [11, 53, 130, 226, 284, 298, 317], 'member': [12], 'of': [13, 30, 96, 133, 142, 188, 210, 283, 291, 305, 322, 357, 362], '11': [15], 'gene': [16], '‘death-from-cancer’': [17], 'signature,': [18], 'which': [19, 205], 'can': [20], 'predict': [21], 'poor': [22], 'response': [23], 'to': [24, 159, 197, 237, 301, 348], 'therapy': [25], 'and/or': [26, 294], 'propensity': [27], 'toward': [28], 'metastasis': [29], 'multiple': [31], 'tumor': [32, 251, 260], 'types,': [33], 'including': [34], 'breast': [35], 'and': [36, 72, 98, 138, 157, 169, 177, 213, 224, 279, 281, 307, 310], 'prostate.': [37], 'However,': [38], 'mechanism': [40], 'for': [41, 56, 91, 101, 154, 259, 272, 320, 366], 'how': [42], 'USP22': [43, 57, 66, 75, 113, 128, 165, 190, 217, 245, 268, 344], 'impacts': [44], 'cancer': [45, 63, 352], 'is': [46, 68, 87, 99, 141, 148, 270], 'currently': [47], 'unknown.': [48], 'Our': [49], 'new': [50], 'data': [51, 107, 124, 265], 'implicate': [52], 'specific': [54], 'role': [55, 79], 'in': [58, 70, 80, 108, 167, 185, 193, 220, 229, 241, 249], 'hormone-dependent': [59, 168], 'cancers,': [60], 'especially': [61], 'prostate': [62, 351], '(PCa)': [64], 'where': [65], 'expression': [67, 121, 176, 254, 278, 293], 'elevated': [69], 'primary': [71], 'metastatic': [73], 'PCa.': [74, 323], 'has': [76, 125], 'an': [77], 'established': [78], 'regulating': [81], 'oncogenic': [82], 'c-Myc': [83, 90, 115, 274, 308], 'activity': [84, 116, 223, 295, 347], 'it': [86], 'recruited': [88], 'by': [89, 202], 'transcriptional': [92], 'activation': [93], 'through': [94], 'deubiquitylation': [95], 'histones,': [97], 'necessary': [100], 'c-Myc-mediated': [102], 'cell': [103, 171, 211], 'transformation.': [104], 'Similarly,': [105], 'our': [106], 'PCa': [109, 147], 'cells': [110], 'demonstrates': [111], 'that': [112, 233, 267, 289], 'controls': [114], 'but': [117, 179], 'does': [118], 'not': [119, 181], 'affect': [120], 'levels.': [122], 'Additional': [123], 'also': [126], 'critical': [131], 'effector': [132], 'androgen': [134], 'receptor': [135], '(AR)': [136], 'levels': [137, 232], 'output.': [139], 'This': [140], 'great': [143], 'clinical': [144], 'relevance': [145], 'since': [146], 'intricately': [149], 'dependent': [150], 'on': [151], 'AR': [152, 174, 195, 222, 230, 277, 306, 346], 'signaling': [153], 'disease': [155, 162], 'initiation': [156], 'progression': [158], 'castrate': [160], 'resistant': [161], '(CRPC).': [163], 'First,': [164], 'overexpression': [166], 'CRPC': [170, 243, 285], 'lines': [172], 'increased': [173], 'protein': [175, 231, 238], 'activity,': [178, 275, 280], 'did': [180], 'perturb': [182], 'transcript.': [183], 'Second,': [184], 'absence': [187], 'ligand,': [189], 'upregulation': [191, 269], 'resulted': [192, 219], 'enhanced': [194], 'recruitment': [196], 'target': [198], 'genes,': [199], 'determined': [201], 'chromatin': [203], 'immunoprecipitation,': [204], 'corresponded': [206], 'with': [207, 256], 'significant': [208, 227], 'enhancement': [209], 'proliferation': [212], 'BrdU': [214], 'incorporation.': [215], 'Third,': [216], 'depletion': [218, 246], 'attenuated': [221], 'caused': [225], 'reduction': [228], 'could': [234, 312], 'be': [235, 313], 'attributed': [236], 'stability.': [239], 'Importantly,': [240], 'setting,': [244], 'dramatically': [247], 'inhibited': [248], 'vivo': [250], 'growth': [252], 'while': [253], 'correlated': [255], 'decreased': [257], 'time': [258], 'regression.': [261], 'In': [262], 'sum,': [263], 'suggest': [266], 'sufficient': [271], 'aberrant': [273], 'altered': [276], 'establishment': [282], 'phenotype.': [286], 'We': [287], 'propose': [288], 'modulation': [290], 'UPS22': [292], 'may': [296], 'present': [297], 'novel': [299, 318], 'platform': [300], 'achieve': [302], 'combinatorial': [303], 'suppression': [304], 'function,': [309], 'therefore': [311], 'potentially': [314], 'developed': [315], 'approach': [319], 'treatment': [321], 'Citation': [324], 'Format:': [325], 'Randy': [326], 'Schrecengost,': [327], 'Jeffry': [328], 'Dean,': [329], 'Tim': [330], 'Stanek,': [331], 'Ruth': [332], 'Birbe,': [333], 'Jessica': [334], 'Hicks,': [335], 'Tapio': [336], 'Visakorpi,': [337], 'Angelo': [338], 'DeMarzo,': [339], 'Steve': [340], 'McMahon,': [341], 'Karen': [342], 'Knudsen.': [343], 'modulates': [345], 'critically': [349], 'regulate': [350], 'progression.': [353], '[abstract].': [354], 'In:': [355], 'Proceedings': [356], '104th': [359], 'Annual': [360], 'Meeting': [361], 'American': [364], 'Association': [365], 'Cancer': [367, 377], 'Research;': [368], '2013': [369], 'Apr': [370], '6-10;': [371], 'Washington,': [372], 'DC.': [373], 'Philadelphia': [374], '(PA):': [375], 'AACR;': [376], 'Res': [378], '2013;73(8': [379], 'Suppl):Abstract': [380], 'nr': [381], '3576.': [382], 'doi:10.1158/1538-7445.AM2013-3576': [383]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2014455946', 'counts_by_year': [], 'updated_date': '2024-12-08T13:05:53.762938', 'created_date': '2016-06-24'}