Publication Information

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'https://openalex.org/W326936453', 'https://openalex.org/W4247904703', 'https://openalex.org/W81352928'], 'related_works': ['https://openalex.org/W4247118944', 'https://openalex.org/W3003252182', 'https://openalex.org/W2295841818', 'https://openalex.org/W2155258698', 'https://openalex.org/W2142685635', 'https://openalex.org/W2128797396', 'https://openalex.org/W2086147308', 'https://openalex.org/W2070765312', 'https://openalex.org/W1991023274', 'https://openalex.org/W1826215572'], 'abstract_inverted_index': {'The': [0, 169, 355, 397, 481, 1373, 1530, 1613, 1664, 1762, 1873, 1917, 1929, 1973, 2137, 2168, 2197, 2345, 2373, 2544, 3416, 3859], 'rapid': [1, 170], 'and': [2, 23, 52, 146, 171, 192, 221, 315, 346, 367, 369, 378, 402, 499, 572, 632, 828, 986, 1044, 1137, 1199, 1246, 1401, 1404, 1437, 1455, 1480, 1492, 1507, 1516, 1519, 1523, 1526, 1540, 1562, 1579, 1617, 1622, 1636, 1640, 1682, 1691, 1748, 1764, 1810, 1858, 1877, 1922, 1944, 1957, 1965, 1985, 2013, 2090, 2125, 2185, 2217, 2230, 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3190, 3197, 3201, 3240, 3261, 3273, 3282, 3309, 3328, 3336, 3341, 3345, 3351, 3363, 3370, 3377, 3396, 3429, 3449, 3455, 3489, 3598, 3622, 3699, 3704, 3717, 3756, 3776, 3854, 3868, 3881, 3899, 3904, 3908, 3960, 3970, 4043, 4049, 4062, 4085, 4107, 4111, 4124, 4139, 4293, 4338, 4354, 4378, 4382, 4387], 'apoptotic': [6, 58, 99, 175, 227, 268, 359, 470, 485, 579, 843, 1065, 1131, 1253, 1318, 1817, 1986, 2410, 2459, 2582, 2831, 2945, 2960, 2984, 3378], 'cells': [7, 59, 176, 228, 360, 471, 844, 1066, 1132, 1254, 1658, 1665, 1799, 1866, 1894, 1930, 1996, 2037, 2062, 2076, 2092, 2139, 2260, 2286, 2299, 2309, 2329, 2347, 2380, 2460, 2819, 2838, 2909, 2946, 2985, 3093, 3299, 3365, 3379, 3611, 4055, 4359], 'plays': [8, 177, 371], 'a': [9, 48, 178, 217, 372, 491, 500, 563, 619, 625, 1039, 1056, 1912, 2423, 2450, 2686, 2728, 2911, 2920, 3029, 3176, 3238, 3268, 3392, 3426, 3463, 3512, 3757, 3778, 3953, 3968, 4044, 4059, 4071, 4075, 4335], 'critical': [10, 179, 373, 1147], 'role': [11, 49, 64, 180, 218, 233, 374, 627, 825, 1058, 1125, 2403], 'in': [12, 20, 54, 93, 181, 189, 223, 262, 375, 839, 1061, 1128, 1380, 1624, 1661, 1717, 1728, 1884, 1904, 1937, 2030, 2045, 2067, 2083, 2315, 2325, 2332, 2406, 2548, 2590, 2668, 3000, 3171, 3187, 3270, 3306, 3331, 3404, 3440, 3845, 3861, 3957, 4052, 4297], 'preventing': [13, 182], 'secondary': [14, 183, 365, 1565], 'necrosis,': [15, 184], 'inflammation': [16, 185, 368, 498], 'as': [17, 19, 186, 188, 349, 428, 490, 504, 506, 1348, 1537, 1650, 1768, 1824, 2019, 2449, 3207, 3209, 3382, 3384, 3433, 3521, 3952, 3975, 4330, 4334, 4362], 'well': [18, 187, 505, 1751, 3208, 3383], 'tissue': [21, 190, 353, 376], 'remodeling': [22, 191, 377], 'regulating': [24, 193], 'immune': [25, 194, 379], 'responses.': [26, 195], 'However,': [27, 196, 1123, 2018, 4070, 4302], 'the': [28, 40, 55, 63, 96, 126, 166, 197, 209, 224, 232, 265, 295, 335, 432, 452, 459, 467, 576, 598, 605, 615, 629, 840, 978, 1047, 1062, 1124, 1138, 1248, 1258, 1283, 1315, 1321, 1324, 1408, 1415, 1445, 1458, 1475, 1484, 1533, 1618, 1625, 1628, 1652, 1668, 1683, 1702, 1718, 1724, 1731, 1745, 1749, 1756, 1798, 1899, 1932, 1966, 1976, 1995, 2000, 2024, 2031, 2041, 2046, 2061, 2075, 2078, 2132, 2177, 2186, 2234, 2256, 2259, 2282, 2285, 2308, 2316, 2321, 2385, 2402, 2407, 2414, 2455, 2541, 2549, 2567, 2586, 2662, 2669, 2672, 2696, 2719, 2735, 2840, 2846, 2914, 2928, 2942, 2955, 2969, 2979, 2996, 3003, 3011, 3026, 3065, 3074, 3134, 3156, 3166, 3243, 3259, 3271, 3276, 3283, 3293, 3303, 3307, 3332, 3342, 3346, 3375, 3409, 3434, 3450, 3456, 3495, 3503, 3508, 3514, 3518, 3604, 3697, 3726, 3734, 3745, 3849, 3862, 3878, 3882, 3920, 3929, 4090, 4104, 4137, 4184, 4196, 4303, 4308, 4339, 4351, 4367, 4375, 4379, 4384], 'molecular': [29, 198], 'details': [30, 199], 'engulfment': [32, 201, 403, 841, 1251, 1746, 2049, 2054, 2235, 2420, 2847, 3191, 3461, 3599, 3840, 4292], 'are': [33, 202, 407, 2044, 2376, 2389, 3707], 'just': [34, 203], 'beginning': [35, 204], 'to': [36, 82, 129, 205, 251, 298, 476, 483, 502, 837, 982, 1145, 1303, 1327, 1598, 1627, 1713, 1754, 1998, 2130, 2357, 2533, 2552, 2733, 2829, 2874, 2919, 2954, 3034, 3052, 3087, 3089, 3132, 3146, 3275, 3292, 3316, 3635, 3725, 3737, 3749, 3848, 3864, 3945, 3966, 3985, 4058, 4065, 4081, 4094, 4135, 4289, 4310, 4325, 4329, 4343], 'be': [37, 130, 150, 206, 299, 319, 1146, 1328, 2704, 3946], 'elucidated.': [38, 207], 'Among': [39, 208, 1320], 'Rho': [41, 66, 104, 112, 167, 210, 235, 273, 281, 336, 1322, 2322, 2397, 2405, 2418, 2537, 2701, 2711, 2724, 2803, 2869, 2938, 3009, 3020, 3330, 3371, 3397, 3706, 3719, 3740, 3751, 3856, 3901, 3925, 3936, 3955, 3962, 4355, 4388], 'family': [42, 211, 2870], 'GTPases,': [43, 212, 3744], 'previous': [44, 213], 'studies': [45, 214, 622], 'have': [46, 156, 215, 325, 623, 975, 1054, 1142, 2039, 2444, 2877, 2994, 3444, 3632, 4118], 'implicated': [47, 216, 489], 'for': [50, 133, 159, 219, 302, 328, 493, 628, 826, 1059, 1148, 1331, 1607, 1634, 1686, 1697, 1744, 1908, 1915, 2070, 2095, 2182, 2194, 2227, 2261, 2287, 2312, 2433, 2823, 3045, 3948], 'Rac': [51, 220, 592, 827, 985, 1635, 2811, 3205, 3357, 3638], 'Cdc42': [53, 222, 1043, 1048, 1060, 3359, 3765, 3870, 3885], 'uptake': [56, 97, 225, 266, 577, 1063, 1156, 1316, 2578, 2924, 2943, 2958, 2970, 2980, 3337, 3376, 3498, 3626, 3922, 4063], 'by': [60, 229, 361, 1414, 1573, 1632, 1671, 1760, 1946, 1954, 2021, 2098, 2142, 2204, 2367, 2421, 2536, 2990, 3149, 3267, 3301, 3462, 3628, 3702, 3891, 4103], 'phagocytes,': [61, 230, 3173], 'yet': [62, 231], 'has': [67, 236, 487, 832, 3084, 3522, 3888, 3963], 'remained': [68, 237], 'unclear.': [69, 238], 'Here,': [70, 239], 'we': [71, 240, 974, 1281, 1290, 1993, 2412, 2443, 2572, 2876, 2993, 3059, 3732], 'present': [72, 241, 1291, 2232], 'evidence': [73, 242, 561, 1292], 'that': [74, 88, 121, 142, 243, 257, 290, 311, 429, 562, 977, 1293, 1309, 2014, 2038, 2453, 2576, 2698, 3016, 3325, 3447, 3696, 3715, 3935, 4066, 4101, 4183, 4306, 4371], 'Rho-GTP': [75, 244, 1580, 1623, 2424, 2547, 2690, 3090], 'levels': [76, 245, 2693], 'decrease': [77, 246, 2553], 'during': [78, 152, 247, 321, 344, 636, 1287, 1298, 2264, 2290, 2399, 2419, 2706, 2726, 3151], 'engulfment.': [79, 115, 248, 284, 1288, 1299, 1336, 3402, 3916, 3950, 4322], 'RhoA': [80, 120, 249, 289, 1127, 1136, 1286, 1294, 1301, 3137, 3354, 3431, 4050, 4108, 4112], 'seems': [81, 250, 1302, 1326], 'negatively': [83, 252, 1304, 3938], 'affect': [84, 253, 1305, 2810, 3289, 3722], 'basal': [85, 254, 1306, 3030, 3940], 'engulfment,': [86, 153, 255, 322, 1307, 2872, 3022, 4383], 'such': [87, 256, 427, 1308, 3974], 'inhibition': [89, 143, 164, 258, 312, 333, 1310, 2699, 2722, 3053, 3189, 3260, 3335, 3340, 3597, 3698, 3771, 4061, 4102, 4381], 'Rho-mediated': [91, 260, 2991], 'signaling': [92, 148, 261, 317, 573, 1313], 'phagocytes': [94, 263, 362, 2028, 2178, 2670, 2966, 3277, 3294, 3333, 3727, 4363], 'enhanced': [95, 264, 1575, 2845, 2968, 3233, 3497, 3921], 'targets.': [100, 269], 'Activation': [101, 270, 3006], 'endogenous': [103, 272, 2417, 3019, 3043, 3329, 3430, 3855, 3869, 3900], 'or': [105, 274, 339, 1590, 1815, 1895, 1906, 2043, 2247, 2318, 2812, 3278, 3285, 3312, 3762, 3902, 3913], 'overexpression': [106, 275, 1037, 3703, 3716, 3775, 3903], 'constitutively': [108, 277, 3159, 3738, 3758, 3763, 3905, 4046], 'active': [109, 278, 3160, 3739, 3750, 3759, 3764, 3906, 4047, 4105], 'forms': [110, 279, 3907, 4106], 'also': [113, 282, 370, 2917, 2967, 3145, 3601, 3624, 4390], 'inhibited': [114, 283, 2941, 3374, 3494, 3517, 3625, 3915], 'By': [116, 285], 'testing': [117, 286], 'mutants': [118, 287, 3161, 4123, 4356], 'selectively': [122, 291], 'activate': [123, 292, 4311], 'downstream': [124, 293, 634, 3972, 4141], 'effectors,': [125, 294, 1323, 4088], 'Rho-kinase': [127, 296, 1141, 1325, 3951, 4193, 4326, 4372], 'seemed': [128, 297], 'primarily': [131, 300, 1329], 'responsible': [132, 301, 1330], 'this': [134, 303, 1332, 3411, 3894], 'inhibitory': [135, 304, 1333, 3031, 3746, 4091, 4319, 4340], 'effect.': [136, 305, 3254], 'Taken': [137, 306, 3917], 'together,': [138, 307], 'these': [139, 308, 2580, 3710, 3932], 'data': [140, 309, 1967, 3014, 3690, 3694, 3933, 4369], 'suggest': [141, 310], 'Rho-': [145, 314], 'Rho-kinase-mediated': [147, 316], 'might': [149, 318, 2703], 'important': [151, 157, 320, 326, 824], 'which': [154, 323, 412, 2442, 2800, 2866, 3083, 3942, 4079, 4126, 4187], 'could': [155, 324, 2005], 'implications': [158, 327], 'several': [160, 329], 'clinical': [161, 330], 'trials': [162, 331], 'involving': [163, 332], 'kinase.': [168, 337, 466, 613], 'Apoptosis': [338], 'programmed': [340], 'cell': [341, 405, 1344, 1376, 2002, 2033, 2429], 'death': [342], 'occurs': [343, 2584], 'development': [345], 'throughout': [347, 2233], 'life': [348], 'part': [350], 'normal': [352], 'homeostasis.': [354], 'prompt': [356], 'removal': [357, 3027], 'prevents': [363], 'their': [364, 415, 633, 1955, 2143, 2827, 3279], 'necrosis': [366], 'response': [380], 'regulation': [381, 2688, 3148], '(1.Aderem': [382], 'A.': [383, 667, 955, 1070, 1160, 1209, 2746, 4217, 4239, 4241, 4247, 4425], 'Underhill': [384], 'D.M.': [385], 'Annu.': [386], 'Rev.': [387], 'Immunol.': [388, 538, 899, 1114], '1999;': [389, 2775, 3119], '17:': [390, 703, 4155], '593-623Crossref': [391], 'PubMed': [392, 523, 552, 659, 672, 687, 705, 724, 741, 786, 808, 857, 879, 903, 918, 943, 968, 1030, 1075, 1094, 1118, 1165, 1192, 1214, 1241, 1278, 1368, 1788, 1844, 2119, 2163, 2501, 2523, 2633, 2655, 2756, 2795, 2900, 3122, 3228, 3483, 3569, 3591, 3684, 3801, 3834, 4003, 4021, 4037, 4157, 4176, 4225, 4257, 4281, 4407], 'Scopus': [393, 524, 553, 660, 673, 688, 706, 725, 742, 787, 809, 858, 880, 904, 919, 944, 969, 1031, 1076, 1095, 1119, 1166, 1193, 1215, 1242, 1369, 1789, 1845, 2120, 2164, 2502, 2524, 2634, 2656, 2757, 2796, 2901, 3123, 3229, 3484, 3570, 3592, 3685, 3802, 3835, 4004, 4022, 4038, 4158, 4177, 4226, 4258, 4282, 4408], '(2148)': [394], 'Google': [395, 526, 542, 555, 662, 675, 690, 708, 727, 744, 789, 811, 821, 860, 882, 906, 921, 946, 971, 1033, 1078, 1097, 1121, 1168, 1195, 1217, 1244, 1279, 1371, 1791, 1847, 2122, 2166, 2504, 2526, 2636, 2658, 2759, 2778, 2798, 2903, 3125, 3231, 3486, 3572, 3594, 3687, 3804, 3837, 4006, 4024, 4040, 4160, 4179, 4228, 4260, 4284, 4410], 'Scholar).': [396, 556, 822, 972, 1034, 1122, 1196, 1372, 1792, 1848, 2123, 2167, 2527, 2659, 2904, 3126, 3487, 3595, 4041, 4180], 'general': [398], 'features': [399], 'apoptosis': [401], 'corpses': [406], 'highly': [408], 'conserved': [409, 568], 'through': [410, 2805, 3047, 3857, 3871, 3928], 'evolution,': [411], 'further': [413, 2717], 'underscores': [414], 'importance.': [416], 'It': [417, 3712], 'is': [418, 558, 1133, 1255, 1296, 3130, 3713, 3844], 'noteworthy': [419, 3714], 'that,': [420], 'compared': [421, 3295, 3733], 'with': [422, 1385, 1603, 1673, 1694, 1740, 1802, 1816, 1820, 1911, 1925, 1983, 2056, 2065, 2086, 2176, 2190, 2255, 2281, 2337, 2350, 2359, 2381, 2436, 2566, 2820, 2839, 2910, 3296, 3366, 3422, 3491, 3741, 3852, 3893, 3919, 4068, 4083, 4113, 4129, 4190, 4350], 'other': [423, 3210, 3742, 4197], 'types': [424, 495, 638, 1261], 'mediated': [430, 3627], 'via': [431], 'Fc': [433, 581], 'receptor': [434, 582, 584, 1150], '(FcR),': [435], '1The': [436], 'abbreviations': [437], 'used': [438, 1535, 1649, 1743, 1753, 2129, 2243, 2269, 2995, 4120, 4361], 'are:': [439], 'FcRFc': [440], 'receptorCRcomplement': [441], 'receptorGEFguanine': [442], 'nucleotide': [443, 586], 'exchange': [444, 587, 1451], 'factorGFPgreen': [445], 'fluorescent': [446, 590, 1807, 2027], 'proteinCRIBRac': [447], 'interactive': [448, 593], 'bindingONC4Aoncogenic': [449], 'form': [450, 596, 1041, 2936, 3063, 3168, 3369, 3395, 4048], 'Rho-specific': [453, 599, 1449, 3048, 3066], 'GEF': [454, 600, 1503, 3067, 3780], 'Lbc': [455, 601, 609, 1454, 1463, 3170, 3180], 'composed': [456, 602], 'only': [458, 604, 3073], 'DH-PH': [460, 606, 1446, 1499, 3075], 'regions': [461, 607, 1477, 3076], 'LbcMLCKmyosin': [463], 'light': [464, 611], 'chain': [465, 612], 'does': [472, 2808], 'not': [473, 1154, 2006, 2051, 2809, 3175, 3288, 3320, 3400, 3413, 3437, 3506, 3616, 3691, 3721, 3768, 3911, 4133, 4195, 4314], 'normally': [474], 'lead': [475, 981, 3051, 3088], 'production': [477], 'pro-inflammatory': [479], 'mediators.': [480], 'failure': [482], 'remove': [484], 'bodies': [486], 'been': [488, 833, 1143, 3085, 3523, 3633, 3889, 3964], 'cause': [492, 3769], 'different': [494, 637, 1203, 1719, 2434, 3971, 4045], 'chronic': [497], 'predisposition': [501], 'cancer,': [503], 'autoimmune': [507], 'diseases': [508], '(2.Mevorach': [509], 'D.': [510, 514, 642, 3115], 'Mascarenhas': [511], 'J.O.': [512], 'Gershov': [513], 'Elkon': [515], 'K.B.': [516], 'J.': [517, 529, 534, 536, 537, 545, 653, 701, 797, 815, 868, 898, 1113, 1357, 1777, 1833, 2108, 2152, 2512, 2644, 2789, 2889, 3472, 3580, 3792, 4153, 4221, 4253, 4270, 4428], 'Exp.': [518, 654], 'Med.': [519, 655, 2790], '1998;': [520, 669, 702, 1072, 1162, 1211, 1270, 4154, 4431], '188:': [521], '2313-2320Crossref': [522], '(586)': [525], 'Scholar,': [527, 543, 663, 676, 691, 709, 728, 745, 790, 812, 861, 883, 907, 922, 947, 1079, 1098, 1169, 1218, 2505, 2637, 2760, 2779, 3573, 3805, 4007, 4025, 4161, 4229, 4261, 4411], '3.Hughes': [528], 'Liu': [530, 1491], 'Y.': [531, 711, 769, 885, 1013, 1081, 1100, 2484, 2616, 3552, 3667, 4245, 4423], 'Van': [532, 770, 1014, 2485, 2617, 3553, 3668], 'Damme': [533], 'Savill': [535], '1997;': [539, 656], '158:': [540], '4389-4397PubMed': [541], '4.Savill': [544], 'Fadok': [546], 'V.': [547], 'Nature.': [548], '2000;': [549, 684, 738, 854, 915, 3225], '407:': [550], '784-788Crossref': [551], '(1291)': [554], 'There': [557], 'now': [559], 'increasing': [560], 'distinct': [564, 1256, 3846], 'set': [565, 4353], 'evolutionarily': [567], 'cellular': [569], 'receptors,': [570], 'ligands,': [571], 'molecules': [574], 'facilitates': [575], 'cells.': [580, 1319, 1897, 2136, 2543], 'complement': [583, 1149], 'guanine': [585, 1450], 'factor': [588, 1452], 'green': [589], 'protein': [591, 3452, 3982], 'binding': [594, 1619, 3272, 3291, 3344, 3724], 'oncogenic': [595, 1472, 3062, 3096, 3199], 'myosin': [610], 'In': [614, 1721, 2660, 2860, 2927, 2952, 3194, 3390, 3501], 'past': [616], 'few': [617], 'years,': [618], 'number': [620, 3969], 'shown': [624, 1144, 2375, 2445, 3086, 3446, 3524, 3634, 3965], 'central': [626], 'Rho-family': [630, 1204, 3211], 'GTPases': [631], 'effectors': [635, 3973, 4131, 4142, 4199], '(5.Cox': [641], 'Chang': [643, 2206], 'P.': [644, 680, 693, 695, 699, 891, 1106, 1490, 3099, 4415], 'Zhang': [645], 'Q.': [646], 'Reddy': [647], 'P.G.': [648], 'Bokoch': [649], 'G.M.': [650], 'Greenberg': [651], 'S.': [652, 814, 3809, 3815, 4251, 4427], '186:': [657], '1487-1494Crossref': [658], '(371)': [661], '6.Caron': [664], 'E.': [665, 749, 794, 865, 951, 953, 993, 1068, 1158, 1173, 1207, 1222, 1354, 1774, 1830, 2105, 2149, 2464, 2509, 2596, 2641, 2886, 3469, 3532, 3577, 3647, 4147, 4265], 'Hall': [666, 954, 1069, 1159, 1208, 2745, 4424], 'Science.': [668, 1071, 1161, 1210], '282:': [670, 1073, 1163, 1212], '1717-1721Crossref': [671, 1074, 1164, 1213], '(819)': [674, 1077, 1167, 1216], '7.Chimini': [677], 'G.': [678, 1524, 4419], 'Chavrier': [679, 698], 'Nat.': [681, 735, 851, 912, 3795, 3828, 4170, 4401], 'Cell.': [682, 736, 777, 852, 913, 934, 959, 1021, 2492, 2624, 3117, 3223, 3560, 3675, 3829, 4171, 4402], 'Bio.': [683, 737, 853, 914, 3830, 4172, 4403], '2:': [685, 739, 855, 916, 2776], 'E191-E196Crossref': [686], '(266)': [689], '8.Massol': [692], 'Montcourrier': [694], 'Guillemot': [696], 'J.C.': [697, 2768], 'EMBO': [700, 4152, 4220, 4252], '6219-6229Crossref': [704], '(206)': [707], '9.Leverrier': [710, 1080], 'Ridley': [712, 894, 1082, 1109], 'A.J.': [713, 895, 897, 1083, 1110, 1112, 4009], 'Curr.': [714, 1084, 1182, 1231, 1268, 4030], 'Biol.': [715, 798, 869, 1085, 1183, 1232, 1269, 1358, 1778, 1834, 2109, 2153, 2513, 2645, 2890, 3118, 3224, 3473, 3581, 3797, 4012, 4271, 4429], '2001;': [716, 778, 800, 818, 871, 900, 935, 960, 1022, 1086, 1115, 1360, 1780, 1836, 2111, 2155, 2493, 2515, 2625, 2647, 2792, 2892, 3475, 3561, 3583, 3676, 3798, 3831, 4013, 4173, 4404], '11:': [717, 1087, 4014], '195-199Abstract': [718, 1088], 'Full': [719, 721, 781, 783, 803, 805, 874, 876, 938, 940, 963, 965, 1025, 1027, 1089, 1091, 1187, 1189, 1236, 1238, 1273, 1275, 1363, 1365, 1783, 1785, 1839, 1841, 2114, 2116, 2158, 2160, 2496, 2498, 2518, 2520, 2628, 2630, 2650, 2652, 2753, 2895, 2897, 3478, 3480, 3564, 3566, 3586, 3588, 3679, 3681, 4016, 4018, 4276, 4278, 4434, 4436], 'Text': [720, 722, 782, 784, 804, 806, 875, 877, 939, 941, 964, 966, 1026, 1028, 1090, 1092, 1188, 1190, 1237, 1239, 1274, 1276, 1364, 1366, 1784, 1786, 1840, 1842, 2115, 2117, 2159, 2161, 2497, 2499, 2519, 2521, 2629, 2631, 2651, 2653, 2754, 2896, 2898, 3479, 3481, 3565, 3567, 3587, 3589, 3680, 3682, 4017, 4019, 4277, 4279, 4435, 4437], 'PDF': [723, 785, 807, 878, 942, 967, 1029, 1093, 1191, 1240, 1277, 1367, 1787, 1843, 2118, 2162, 2500, 2522, 2632, 2654, 2755, 2899, 3482, 3568, 3590, 3683, 4020, 4280], '(142)': [726, 1096], '10.Albert': [729], 'M.L.': [730, 846], 'Kim': [731, 847], 'J.I.': [732, 848], 'Birge': [733, 849], 'R.B.': [734, 850], '899-905Crossref': [740, 856], '(333)': [743, 859], '11.Gumienny': [746, 3529, 3644], 'T.L.': [747, 991, 2462, 2594, 3530, 3645], 'Brugnera': [748, 793, 864, 992, 1353, 1773, 1829, 2104, 2148, 2463, 2508, 2595, 2640, 2885, 3468, 3531, 3576, 3646], 'Tosello-Trampont': [750, 994, 2465, 2597, 3533, 3648], 'A.C.': [751, 995, 2466, 2598, 3534, 3649], 'Kinchen': [752, 996, 2467, 2599, 3535, 3650], 'J.M.': [753, 997, 2468, 2600, 3536, 3651], 'Haney': [754, 998, 2469, 2601, 3537, 3652], 'L.B.': [755, 999, 2470, 2602, 3538, 3653], 'Nishiwaki': [756, 1000, 2471, 2603, 3539, 3654], 'K.': [757, 1001, 1177, 1226, 1493, 2472, 2604, 2744, 3221, 3540, 3655, 4207, 4215, 4219, 4235, 4237, 4413], 'Walk': [758, 1002, 2473, 2605, 3541, 3656], 'S.F.': [759, 1003, 2474, 2606, 3542, 3657], 'Nemergut': [760, 1004, 2475, 2607, 3543, 3658], 'M.E.': [761, 1005, 2476, 2608, 3544, 3659], 'Macara': [762, 1006, 2477, 2609, 3545, 3660], 'I.G.': [763, 1007, 2478, 2610, 3546, 3661], 'Francis': [764, 1008, 2479, 2611, 3547, 3662], 'R.': [765, 887, 1009, 1102, 2480, 2612, 2787, 3548, 3663, 4151], 'Schedl': [766, 1010, 2481, 2613, 3549, 3664], 'T.': [767, 1011, 2482, 2614, 3111, 3550, 3665, 4201, 4205, 4213, 4231, 4263, 4417], 'Qin': [768, 1012, 2483, 2615, 3551, 3666], 'Aelst': [771, 1015, 2486, 2618, 3554, 3669, 3994], 'L.': [772, 1016, 2487, 2619, 2764, 3555, 3670, 3995, 4267, 4269], 'Hengartner': [773, 1017, 2488, 2620, 3556, 3671], 'M.O.': [774, 1018, 2489, 2621, 3557, 3672], 'Ravichandran': [775, 795, 866, 1019, 1355, 1775, 1831, 2106, 2150, 2490, 2510, 2622, 2642, 2887, 3470, 3558, 3578, 3673], 'K.S.': [776, 796, 867, 1020, 1356, 1776, 1832, 2107, 2151, 2491, 2511, 2623, 2643, 2888, 3471, 3559, 3579, 3674], '107:': [779, 1023, 2494, 2626, 3562, 3677], '27-41Abstract': [780, 1024, 2495, 2627, 3563, 3678], '(464)': [788, 1032, 2503, 2635, 3571, 3686], '12.Tosello-Trampont': [791, 862, 2506, 2638, 2883, 3574], 'A.-C.': [792, 863, 1352, 1772, 1828, 2103, 2147, 2507, 2639, 2884, 3467, 3575], 'Chem.': [799, 870, 1359, 1779, 1835, 2110, 2154, 2514, 2646, 2891, 3474, 3582, 4272, 4430], '276:': [801, 872, 1361, 1781, 1837, 2112, 2156, 2516, 2648, 2893, 3476, 3584], '13797-13802Abstract': [802, 873, 1362, 1782, 1838, 2113, 2157, 2517, 2649, 2894, 3477, 3585], '(69)': [810, 881, 1370, 1790, 1846, 2121, 2165, 2525, 2657, 2902, 3124, 3485, 3593], '13.Greenberg': [813], 'Cell': [816, 1337, 4011], 'Sci.': [817, 2749], '114:': [819], '1039-1040PubMed': [820], 'An': [823], 'its': [829, 1517, 4086, 4114, 4318], 'upstream': [830], 'activators': [831], 'demonstrated': [834], 'from': [835, 1257, 2011, 2015, 2135, 2540], 'worm': [836, 3457], 'mammals': [838], '(10.Albert': [845], '14.Leverrier': [884, 1099], 'Lorenzi': [886, 1101], 'Blundell': [888, 1103], 'M.P.': [889, 1104, 3103], 'Brickell': [890, 1105], 'Kinnon': [892, 1107], 'C.': [893, 1108, 1508, 2770, 2862], 'Thrasher': [896, 1111], '166:': [901, 1116], '4831-4834Crossref': [902, 1117], '(106)': [905, 1120], '15.Reddien': [908], 'P.W.': [909], 'Horwitz': [910], 'H.R.': [911, 957], '131-136Crossref': [917], '(341)': [920], '16.Wu': [923], 'Y.C.': [924], 'Tsai': [925], 'M.C.': [926, 4027], 'Cheng': [927, 3106], 'L.C.': [928], 'Chou': [929], 'C.J.': [930, 3794], 'Weng': [931], 'N.Y.': [932], 'Dev.': [933, 958, 3999, 4033], '1:': [936, 961], '491-502Abstract': [937], '(137)': [945], '17.Zhou': [948], 'Z.': [949], 'Caron': [950, 1172, 1221], 'Hartwieg': [952], 'Horvitz': [956], '477-489Abstract': [962], '(143)': [970], 'Previously,': [973], 'observed': [976, 2574, 3263, 3890, 4182], 'CrkII/Dock180/ELMO': [979], 'proteins': [980, 1410, 1596, 1759, 2538, 2804, 3630, 3937], 'activation': [983, 1139, 3041, 3206, 3327, 3639, 3853, 3867, 3898], 'promote': [987, 3636], 'Rac-dependent': [988, 3464], '(11.Gumienny': [990, 2461, 2593], 'Studies': [1035], 'using': [1036, 1574, 1970, 2300, 2368], 'dominant-negative': [1040, 3394, 3515], 'mice': [1045], 'lacking': [1046, 3242], 'effector': [1049, 4121], 'WASP': [1050], '(Wiskott-Aldrich': [1051], 'syndrome': [1052], 'protein)': [1053], 'suggested': [1055, 2685, 3324, 3695, 3934, 4100, 4370], 'positive': [1057, 1855, 1865, 1870], '(6.Caron': [1067, 1157, 1206], 'less': [1134, 1859], 'clear.': [1135], '(CR)-mediated': [1151], 'but': [1153, 2807, 3174, 3319, 3355, 3910, 4132, 4194, 4313], 'FcR-mediated': [1155], '18.Olazabal': [1170, 1219], 'I.M.': [1171, 1220], 'May': [1174, 1223], 'R.C.': [1175, 1224], 'Schilling': [1176, 1225], 'Knecht': [1178, 1227], 'D.A.': [1179, 1228], 'Machesky': [1180, 1229], 'L.M.': [1181, 1230], '2002;': [1184, 1233, 4000, 4034], '12:': [1185, 1234, 4035], '1413-1418Abstract': [1186, 1235], '(200)': [1194, 1243], 'Because': [1197, 2978], 'FcR-': [1198], 'CR-mediated': [1200], 'utilize': [1202], 'members': [1205], 'Scholar),': [1245, 1280, 2799, 3838, 4285], 'because': [1247, 3024, 3754], 'outcome': [1249], 'above': [1259, 3013, 3264, 4368], 'two': [1260, 1741, 2392], '(19.Fadok': [1264], 'V.A.': [1265], 'Henson': [1266], 'P.M.': [1267], '8:': [1271, 3799], 'R693-R695Abstract': [1272], 'examined': [1282, 2413, 3257], 'contribution': [1284], 'Here': [1289], 'activity': [1295, 2415, 2702, 2725, 3245], 'down-regulated': [1297], 'Moreover,': [1300, 3774], 'RhoA-mediated': [1312], 'enhances': [1314, 3460], 'effect': [1334, 2736, 2956, 3032, 3735, 3747, 3850, 4092, 4320, 4341], 'on': [1335, 1890, 1931, 2077, 2384, 2458, 2957, 4321], 'Culture—The': [1338], 'phagocytic': [1339], 'LR73': [1340, 1606, 1657, 1893, 2298, 2328, 2428, 2837, 2908, 2965, 3172, 3364, 3610, 4358], 'Chinese': [1341], 'hamster': [1342], 'ovary': [1343], 'line': [1345, 1377], 'was': [1346, 1378, 1601, 1630, 1648, 1711, 1726, 2174, 2222, 2231, 2242, 2268, 2531, 2558, 2666, 2731, 3265, 3412, 3436, 3600, 3607, 3926, 4286, 4373], 'cultured': [1347, 1379], 'described': [1349, 1769, 1825], 'previously': [1350, 1770, 1826, 2446, 2575, 2879, 3445, 3525], '(12.Tosello-Trampont': [1351, 1771, 1827, 2102, 2146, 3466], 'J774': [1374, 1896, 2816, 4053, 4298], 'macrophage': [1375, 2818, 4054], 'RPMI': [1381], '1640': [1382], 'medium': [1383, 1675, 1696, 1939, 2069, 2085, 2193], 'supplemented': [1384], '10%': [1386], 'fetal': [1387], 'calf': [1388], 'serum,': [1389], '10': [1390, 2225, 2245], 'mm': [1391], 'HEPES,': [1392], 'pH': [1393], '7.4,': [1394], '0.05': [1395], 'μm': [1396, 1804, 2058, 2246, 2249, 2275, 2438, 2973], 'β-mercaptoethanol,': [1397], '4.5': [1398], 'g/liter': [1399], 'glucose,': [1400], 'antibiotics.': [1402], 'Plasmids': [1403], 'Antibodies—The': [1405], 'plasmids': [1406, 1685, 2294], 'encoding': [1407, 1474, 1483, 2913], 'following': [1409], 'were': [1411, 1536, 1571, 1615, 1659, 1666, 1692, 1766, 1800, 1852, 1867, 1875, 1901, 1919, 1934, 1951, 1963, 1968, 2063, 2080, 2093, 2128, 2140, 2188, 2295, 2310, 2330, 2348, 2431, 2986, 4348, 4360], 'kindly': [1412], 'provided': [1413], 'indicated': [1416, 1684, 2293], 'investigators:': [1417], 'Myc-tagged': [1418, 1435], 'wt': [1419], 'CrkII': [1420, 3453, 3492, 3614], '(M.': [1421], 'Matsuda,': [1422], 'Japan);': [1423], 'C3': [1424, 2170, 2738, 2821, 2841, 2915, 2962, 3423, 3930], 'exoenzyme': [1425, 2739, 2822, 2842, 2916], '(A.': [1426, 1521], 'Reynolds,': [1427], 'Vanderbilt': [1428], 'University);': [1429], 'FLAG-tagged': [1430], 'Rac1Q61L,': [1431], 'Rac1T17N,': [1432], 'RhoQ63L,': [1433], 'RhoT19N,': [1434], 'Cdc42Q61L,': [1436], 'Cdc42T17N': [1438], '(T.': [1439, 1505], 'Parsons,': [1440], 'University': [1441, 1467, 1495, 2208], 'Virginia);': [1443], 'ONC4A,': [1444], 'region': [1447, 1500], '(GEF)': [1453], 'PS': [1456], '1,': [1457], 'DH/PH': [1459], 'deleted': [1460], 'mutant': [1461, 1486, 3178, 3239, 3886, 4073, 4305, 4386], '(D.': [1464], 'Toksoz,': [1465], 'Tufts': [1466], 'School': [1468], 'Medicine,': [1470], 'Boston);': [1471], 'Vav2-GFP': [1473, 1482], 'PH/DH': [1476], 'Vav2,': [1479], 'C-term': [1481], 'DH/PH-deleted': [1485], 'Vav2': [1488, 3202, 3241], '(B.': [1489], 'Burridge,': [1494], 'North': [1497], 'Carolina);': [1498], 'Cdc42-specific': [1502, 3779], 'intersectin': [1504], 'Karnoub': [1506], 'Der);': [1509], 'Scar-WA': [1510], 'plasmid': [1511, 1715, 2912, 3606], '(Laura': [1512], 'Machesky);': [1513], 'GFP-tagged': [1514], 'G14VRhoA': [1515], 'mutants,': [1518], 'GFP-DAD': [1520], 'Palazzo': [1522], 'Gunderson);': [1525], 'various': [1527, 3987], 'mDia': [1528, 4191, 4392], 'plasmids.': [1529], 'sources': [1531], 'antibodies': [1534, 1566], 'follows:': [1538], 'anti-GFP': [1539], 'anti-Cdc42': [1541], '(Santa': [1542], 'Cruz': [1543], 'Biotechnology,': [1544, 1558], 'Santa': [1545], 'Cruz,': [1546], 'CA),': [1547], 'anti-FLAG': [1548], 'M2': [1549], '(Sigma),': [1550], 'anti-Crk': [1551], '(Transduction': [1552], 'Laboratories,': [1553], 'Lexington,': [1554], 'KY),': [1555], 'anti-Rac': [1556], '(Upstate': [1557], 'Lake': [1559], 'Placid,': [1560], 'NY)': [1561], 'horseradish': [1563], 'peroxidase-conjugated': [1564], '(Amersham': [1567], 'Biosciences).': [1568], 'All': [1569], 'immunoblots': [1570], 'developed': [1572], 'chemiluminescence': [1576], '(Pierce).': [1577], 'Rac-GTP': [1578, 1621, 2665, 2692], 'Pull-down': [1581], 'Assay—Bacterially': [1582], 'produced': [1583], 'glutathione': [1584, 1591], 'S-transferase-Cdc42/CRIB': [1585], 'domain': [1586, 1593, 4122], 'p21-activated': [1588], 'kinase': [1589, 3983], 'S-transferase-Rho-binding': [1592], 'rhotekin': [1595], 'bound': [1597, 2012, 3142], 'glutathione-Sepharose': [1599], 'beads': [1600, 1614, 1629, 1808, 2066, 2134, 2187, 2257, 2283, 2975, 2982, 2999, 3387, 4294], 'incubated': [1602, 1693, 1801, 1988, 2064, 2311, 2432], 'lysates': [1604, 1626], '1': [1608], 'h': [1609, 1688, 1699, 1795, 2263, 2289, 2305, 2314, 2563, 2825], 'at': [1610, 1989, 2179, 2224, 2244, 2270, 2585, 2671, 3313], '4': [1611, 1990, 3314], '°C.': [1612, 1991], 'washed,': [1616], 'analyzed': [1631, 1945, 1969, 2094, 2366], 'immunoblotting': [1633, 1765], 'Rho,': [1637, 3044, 3909], 'respectively.': [1638], 'Transfection': [1639], 'Immunoblotting—For': [1641], 'transient': [1642, 2931], 'transfections,': [1643], 'LipofectAMINE': [1644, 1680, 2301], '2000': [1645, 1681, 2302], 'reagent': [1646, 1737], '(Invitrogen)': [1647], 'per': [1651], "manufacturer's": [1653], 'recommendations.': [1654], 'Briefly,': [1655], '100,000': [1656], 'plated': [1660, 1878], '24-well': [1662], 'plates.': [1663], 'transfected': [1667, 2138, 2296, 3608], 'next': [1669], 'day': [1670], 'incubation': [1672, 1914, 2565], 'plain': [1674], 'containing': [1676], '1.5': [1677], 'μl': [1678, 1886], '7': [1687], 'before': [1689, 1700], 'washing': [1690], 'fresh': [1695, 2191], '16–20': [1698], 'performing': [1701, 2422, 3302], 'assays.': [1704], 'When': [1705, 3731], 'cotransfecting': [1706], 'multiple': [1707, 2379], 'plasmids,': [1708], 'carrier': [1709], 'DNA': [1710], 'added': [1712, 2189, 2253, 2279], 'match': [1714], 'concentration': [1716], 'samples.': [1720], 'some': [1722, 3405, 4130], 'experiments,': [1723], 'transfection': [1725, 1736, 2906, 2932, 3362], 'done': [1727], 'triplicates': [1729, 1907], '(using': [1730], 'same': [1732, 2386, 2929, 4352], 'master': [1733], 'mix': [1734], 'plus': [1738], 'plasmids),': [1739], 'wells': [1742, 1918], 'assays': [1747, 1900, 2055, 2592], 'third': [1750], 'being': [1752], 'analyze': [1755], 'expression': [1757, 3196, 3448, 3755], 'immunoblots.': [1761], 'lysis': [1763], 'performed': [1767, 2732], 'Phagocytosis': [1793, 2713], 'Assays—16–20': [1794], 'after': [1796, 2306, 2554, 2561], 'transfection,': [1797, 2307], '2': [1803, 2057, 2071, 2195, 2262, 2288, 2313, 2437, 2562, 2972], 'carboxylate-modified': [1805, 2059, 2439, 2974, 2997, 3386], 'red': [1806], '(Sigma': [1809], 'Molecular': [1811], 'Probes,': [1812], 'Eugene,': [1813], 'OR)': [1814], 'thymocytes': [1818, 1851, 1874, 1950, 1980, 1987, 2042, 2832], 'labeled': [1819], 'CM-Orange': [1821], '(Molecular': [1822, 2363], 'Probes),': [1823], '40–50%': [1849], 'Annexin': [1853, 1863], 'V': [1854, 1864], '(i.e.': [1856, 1871], 'apoptotic),': [1857], 'than': [1860, 3339], '5%': [1861], 'propidium': [1868], 'iodide': [1869], 'necrotic).': [1872], 'washed': [1876, 1923], '(at': [1879], '0.7–1': [1880], '×': [1881], '106': [1882], 'cells/well': [1883], '300': [1885], 'growth': [1888], 'medium)': [1889], 'top': [1891], 'Routinely,': [1898, 1960], 'carried': [1902], 'out': [1903, 1953], 'duplicates': [1905], 'each': [1909, 2096], 'condition': [1910], '50-min': [1913], 'thymocytes.': [1916, 2017], 'then': [1920, 3037, 3256], 'aspirated': [1921], 'twice': [1924], 'cold': [1926, 1938, 2084], 'phosphate-buffered': [1927, 2338, 2351], 'saline.': [1928], 'plate': [1933, 2079], 'trypsinized,': [1935, 2081], 'resuspended': [1936, 2082], '(with': [1940], '0.1%': [1941], 'sodium': [1942, 2088], 'azide),': [1943], 'flow': [1947, 2100], 'cytometry.': [1948], 'Unengulfed': [1949], 'gated': [1952], 'forward': [1956], 'side': [1958], 'scatter.': [1959], '10,000–20,000': [1961, 2091], 'events': [1962], 'collected,': [1964], 'CellQuest': [1971], 'software.': [1972], 'controls': [1974], 'included': [1975], 'use': [1977], 'live': [1979], '(not': [1981], 'treated': [1982], 'dexamethasone)': [1984], 'Although': [1992, 3403, 4366], 'trypsinized': [1994], 'prior': [1997, 2356], 'analysis,': [1999], 'fluorescence-activated': [2001, 2032], 'sorter': [2003, 2034], 'assay': [2004, 2035, 2730, 3305], 'distinguish': [2007, 2131], 'between': [2008, 3138, 3866], 'fluorescence': [2009, 2145], 'derived': [2010, 2539], 'engulfed': [2016, 2040], 'determined': [2020], 'confocal': [2022, 2371], 'microscopy,': [2023], 'majority': [2025], 'scored': [2029], 'represent': [2036], 'process': [2047], '(data': [2050, 3615], 'shown).': [2052, 3617, 3692], 'For': [2053], 'beads,': [2060, 2441], 'serumfree': [2068], 'h.': [2072, 2196], 'After': [2073], 'washing,': [2074], '0.5%': [2087], 'azide,': [2089], 'point': [2097, 2589], 'two-color': [2099], 'cytometry': [2101], 'Forward': [2124], 'side-scatter': [2126], 'parameters': [2127], 'unbound': [2133], 'recognized': [2141], 'GFP': [2144], 'ADP-ribosyltransferase': [2169], '(intact': [2171], 'toxin,': [2172, 3931], 'Sigma)': [2173], 'pre-incubated': [2175, 2223], '5': [2180], 'μg/ml': [2181], '16': [2183, 2824], 'h,': [2184], 'serum-free': [2192, 2326], 'intact': [2198], 'Clostridium': [2199, 2741], 'difficile': [2200, 2863], 'toxin': [2201, 2864], 'B': [2202], '(provided': [2203], 'Dr.': [2205, 2211, 2218], 'Hahn,': [2207], 'Virginia;': [2210], 'Charalabos': [2212], 'Pothoulakis,': [2213], 'Harvard': [2214], 'Medical': [2215], 'School;': [2216], 'Popoff,': [2219], 'Institut': [2220], 'Pasteur)': [2221], 'ng/ml': [2226], '15': [2228], 'min': [2229, 2556], 'assay.': [2236, 2426], 'Y-27632': [2237, 2324], '(Calbiochem,': [2238], 'San': [2239], 'Diego,': [2240], 'CA)': [2241], '30': [2248, 2274, 2555], '(as': [2250, 2276, 3887], 'indicated)': [2251, 2277], 'along': [2254, 2280], 'onto': [2258, 2284], 'uptake.': [2265, 2291, 3510], 'ML-7': [2266], '(Calbiochem)': [2267], '5,': [2271], '10,': [2272], 'Microscopy—The': [2292], 'into': [2297, 3609], 'reagent.': [2303], '20': [2304], 'presence': [2317, 3308], 'absence': [2319], 'inhibitor': [2323], 'medium.': [2327], 'fixed': [2331], '3.7%': [2333], 'paraformaldehyde': [2334], 'permeabilized': [2336, 2346], 'saline/0.1%': [2339], 'bovine': [2340, 2353], 'serum': [2341, 2354], 'albumin/0.1%': [2342], 'Triton': [2343], 'X-100.': [2344], 'blocked': [2349], 'saline/1%': [2352], 'albumin': [2355], 'staining': [2358], 'Alexa': [2360], 'Fluor': [2361], '568-phalloidin': [2362], 'Probes)': [2364], 'an': [2369, 2934, 3061, 3198, 3367, 3770], 'Olympus': [2370], 'microscope.': [2372], 'images': [2374], 'representative': [2377, 2390], 'similar': [2382, 2679, 2873, 2921, 4346], 'phenotype': [2383], 'slide': [2387], 'independent': [2393], 'experiments.': [2394, 3005], 'Down-regulation': [2395], 'Activity': [2398], 'Engulfment—To': [2400], 'assess': [2401], 'cells,': [2411, 2961], 'pull-down': [2425], 'Phagocytic': [2427], 'lines': [2430], 'times': [2435], 'latex': [2440], 'can': [2447, 4127, 4188, 4389], 'function': [2448], 'simplified': [2451, 2529], 'target': [2452, 2530, 2542], 'mimics': [2454], 'negative': [2456], 'charge': [2457], 'This': [2528, 2683, 3322, 3843, 4098, 4323], 'chosen': [2532], 'avoid': [2534], 'contamination': [2535], 'level': [2545, 2663], 'phagocyte': [2550], 'began': [2551], 'dramatically': [2559], 'decreased': [2560], 'targets': [2568, 2583, 3274, 3347], '(Fig.': [2569, 2681, 2833, 2880, 2925, 2947, 2976, 3192, 3235, 3348, 3380, 3388, 3499, 3526, 3772, 3841, 3990, 4096, 4143, 4300, 4364], '1A).': [2570], 'Interestingly,': [2571], 'had': [2573, 3252], 'maximal': [2577, 3637, 3641], 'surrogate': [2581], '2-h': [2587, 2675], 'time': [2588, 2676], 'our': [2591, 3441], 'contrast,': [2661, 3195, 3391, 3502], 'increased': [2667, 2826, 3408], '30-min': [2673], 'points': [2677], 'under': [2678, 3709], 'conditions': [2680], '1B).': [2682], 'result': [2684, 4099], 'reciprocal': [2687], 'raised': [2695], 'possibility': [2697], 'beneficial': [2705], 'phagocytosis.': [2707, 3055], 'Inhibition': [2708], 'Endogenous': [2710, 3008], 'Promotes': [2712], 'Apoptotic': [2715], 'Cells—To': [2716], 'examine': [2718], 'benefit': [2720], 'phagocytosis,': [2727], 'test': [2734, 4136], '(from': [2740], 'botulinum)': [2742], '(20.Aktories': [2743], 'Trends': [2747, 4010], 'Pharmacol.': [2748], '1989;': [2750], '10:': [2751], '415-418Abstract': [2752], '(124)': [2758], '21.Richard': [2761], 'J.F.': [2762], 'Petit': [2763], 'Gibert': [2765], 'M.': [2766, 3811, 3817, 3997, 4203, 4209, 4211, 4233], 'Marvaud': [2767], 'Bouchaud': [2769], 'Popoff': [2771], 'M.R.': [2772], 'Int.': [2773, 2788], 'Microbiol.': [2774, 2791], '185-194PubMed': [2777], '22.Just': [2780], 'I.': [2781], 'Hofmann': [2782], 'F.': [2783], 'Genth': [2784], 'H.': [2785, 4421], 'Gerhard': [2786], '291:': [2793], '243-250Crossref': [2794], '(37)': [2797], 'specifically': [2801], 'inactivates': [2802], 'ADP-ribosylation': [2806], 'Cdc42.': [2813], 'Pre-treatment': [2814, 2835], 'murine': [2817], 'ability': [2828, 3863, 4309], 'engulf': [2830, 3865], '2A).': [2834], 'likewise': [2843], 'significantly': [2844, 3459], '(fold': [2848], 'increase': [2849], '1.23': [2851], '+': [2852], '0.09,': [2853], 'p': [2854], '<': [2855], '0.01,': [2856], 'n': [2857], '=': [2858], '3).': [2859], 'comparison,': [2861], 'B,': [2865], 'inhibits': [2867], 'all': [2868, 4084], 'GTPases-inhibited': [2871], 'what': [2875], 'seen': [2878, 3602, 3851, 3923, 4067], '2B;': [2881], 'Ref.': [2882, 3217], 'Transient': [2905], 'led': [2918, 4057], 'enhancement': [2922, 3421], '2B).': [2926], 'experiment,': [2930], 'activated': [2935, 3368, 3705, 3718, 3874], '(RhoQ63L)': [2939, 3372], 'partially': [2940, 3373], '2B': [2948], 'see': [2950, 3079, 3182, 3213, 3248], 'below).': [2951], 'addition': [2953], 'pre-treatment': [2963], '2C).': [2977], 'both': [2987], 'regulated': [2988], 'similarly': [2989], 'signaling,': [2992], '2-μm': [2998, 3385], 'many': [3001], 'subsequent': [3004, 3095], 'Inhibits': [3010, 3360], 'Engulfment—The': [3012], 'implied': [3015], 'inactivation': [3017], 'promotes': [3021, 3204], 'possibly': [3023], 'due': [3033, 3736, 3748, 4093, 4342], 'Rho.': [3035, 4344], 'We': [3036, 3255, 3443, 4181], 'asked': [3038], 'whether': [3039, 3258], 'forced': [3040, 3326, 3897], 'example': [3046], 'GEFs,': [3049], 'would': [3050], 'To': [3056], 'achieve': [3057], 'this,': [3058], 'expressed': [3060], 'Lbc,': [3068], 'denoted': [3069], 'ONC4A': [3070, 3129, 3167, 3284], '(composed': [3071], 'Lbc;': [3078], 'supplemental': [3080, 3183, 3214, 3249], 'Fig.': [3081, 3184, 3215, 3250, 3729], '1),': [3082, 3185], 'loading': [3091], 'within': [3092], 'transformation': [3097], '(23.Sterpetti': [3098], 'Hack': [3100], 'A.A.': [3101], 'Bashar': [3102], 'Park': [3104], 'B.': [3105], 'S.D.': [3107], 'Knoll': [3108], 'J.H.': [3109], 'Urano': [3110], 'Feig': [3112], 'L.A.': [3113], 'Toksoz': [3114], 'Mol.': [3116, 3222], '19:': [3120], '1334-1345Crossref': [3121], 'Overexpression': [3127, 3281, 3350], 'expected': [3131], 'allow': [3133], 'cycling': [3135], 'GTP': [3139], 'GDP': [3141], 'states': [3143], 'permit': [3147], 'Rho-GAPs': [3150], '(and': [3153], 'thereby': [3154], 'overcome': [3155, 3947], 'limitations': [3157], 'RhoA).': [3163], 'Expression': [3164, 4042], 'DH-PH-deleted': [3177], '(PS1;': [3181], 'resulted': [3186], 'significant': [3188], '3A).': [3193], 'version': [3200], '(that': [3203], 'GTPases;': [3212], '1;': [3216], '24.Liu': [3218], 'B.P.': [3219], 'Burridge': [3220], '20:': [3226], '7160-7169Crossref': [3227], '(171)': [3230], 'Scholar)': [3232], '3B),': [3236], 'whereas': [3237], 'catalytic': [3244], '(denoted': [3246], 'C-ter;': [3247], '1)': [3251], 'no': [3253], 'caused': [3266, 3701], 'defect': [3269], 'internalization.': [3280], 'PS1': [3286], 'did': [3287, 3399, 3505, 3720, 3767], 'particle': [3290, 3723], 'control': [3297], 'vector-transfected': [3298], '(assessed': [3300], '1%': [3310], 'azide': [3311], '°C': [3315], 'prevent': [3317], 'internalization': [3318], 'binding).': [3321], 'finding': [3323], 'causes': [3334], 'rather': [3338], 'initial': [3343], '3C).': [3349, 3730], 'Constitutively': [3352], 'Active': [3353], 'Not': [3356], 'Engulfment—Transient': [3361], '2B)': [3381], '4A).': [3389, 3500], 'weak': [3393], '(RhoT19N)': [3398], 'inhibit': [3401, 3507, 4291], 'experiments': [3406], 'RhoT19N': [3407, 3435, 3504], 'uptake,': [3410, 3520, 3941], 'consistently': [3414], 'observed.': [3415], 'better': [3417], 'more': [3419], 'consistent': [3420], 'likely': [3424, 3876, 4374], 'reflects': [3425, 3877], 'higher': [3427], 'degree': [3428], 'inhibition,': [3432], 'very': [3438], 'potent': [3439, 4060], 'hands.': [3442], 'adapter': [3451], '(homologue': [3454], 'CED-2)': [3458], 'mechanism': [3465], 'Coexpression': [3488], 'RhoQ63L': [3490, 3605, 3623], 'potently': [3493, 4290], 'CrkII-mediated': [3496, 3509, 3519], 'As': [3511, 3618], 'control,': [3513], 'RacT17N': [3516], '4A;': [3527], 'Refs.': [3528, 3992, 4145], 'Comparable': [3596], 'when': [3603, 3924, 4295, 4357], 'stably': [3612], 'expressing': [3613], 'another': [3619], 'approach,': [3620], 'coexpression': [3621], 'ELMO1/Dock180/CrkII': [3629], '(which': [3631], 'phagocytosis)': [3642], '(Ref.': [3643], 'Scholar': [3688], 'These': [3693], 'dominant': [3708], 'conditions.': [3711], '(see': [3728], 'small': [3743], 'appeared': [3752], 'specific,': [3753], 'Rac1': [3760, 3912], '(RacQ61L)': [3761], '(Cdc42Q61L)': [3766], '4B).': [3773, 3842], 'Intersectin,': [3777], '(25.Karnoub': [3781], 'A.E.': [3782], 'Worthylake': [3783], 'D.K.': [3784], 'Rossman': [3785], 'K.L.': [3786], 'Pruitt': [3787], 'W.M.': [3788], 'Campbell': [3789], 'S.L.': [3790], 'Sondek': [3791], 'Der': [3793], 'Struct.': [3796], '1037-1041Crossref': [3800], '(84)': [3803], '26.Hussain': [3806], 'N.K.': [3807], 'Jenna': [3808], 'Glogauer': [3810], 'Quinn': [3812], 'C.C.': [3813], 'Wasiak': [3814], 'Guipponi': [3816], 'Antonarakis': [3818], 'S.E.': [3819], 'Kay': [3820], 'B.K.': [3821], 'Stossel': [3822], 'T.P.': [3823], 'Lamarche-Vane': [3824], 'N.': [3825, 4243, 4249], 'McPherson': [3826], 'P.S.': [3827], '3:': [3832, 4174, 4405], '927-932Crossref': [3833], '(304)': [3836], 'promoted': [3839], 'contrast': [3847], 'ONC4A.': [3858], 'difference': [3860], 'Intersectin': [3872], 'Cdc42Q61L': [3875], 'lower': [3879], 'potency': [3880], '"constitutively': [3883], 'active"': [3884], 'others': [3892], 'mutant).': [3895], 'Thus,': [3896], 'Cdc42,': [3914], 'together': [3918], 'inactivated': [3927], 'regulate': [3939], 'may': [3943], 'need': [3944], 'optimal': [3949], 'Key': [3954], 'Effector': [3956], 'Negative': [3958], 'Regulation': [3959], 'Engulfment—GTP-bound': [3961], 'bind': [3967, 4391], 'p140mDia,': [3976], 'Rho-kinases,': [3977], 'citron,': [3978], 'rhotekin,': [3979], 'rhophilin,': [3980], 'N': [3984], 'mediate': [3986], 'functional': [3988], 'outcomes': [3989], '5A;': [3991, 4144], '27.Van': [3993], 'Symons': [3996], 'Genes': [3998], '16:': [4001], '1032-1054Crossref': [4002], '(191)': [4005], '28.Ridley': [4008], '471-477Abstract': [4015], '(649)': [4023], '29.Frame': [4026], 'Brunton': [4028], 'V.G.': [4029], 'Opin.': [4031], 'Genet.': [4032], '36-43Crossref': [4036], '(76)': [4039], '(RhoAG14V)': [4051], 'again': [4056], '(similar': [4064], 'RhoAQ63L).': [4069], 'RhoAG14V': [4072, 4095], 'carrying': [4074], 'concurrent': [4076], 'T37Y': [4077], 'mutation,': [4078], 'fails': [4080], 'interact': [4082, 4128, 4189], 'known': [4087, 4198], 'abolished': [4089], '5B).': [4097, 4301], 'involves': [4109], 'interaction': [4110], 'effectors.': [4115], 'Other': [4116], 'investigators': [4117], 'successfully': [4119], 'RhoA,': [4125], 'others,': [4134], 'involvement': [4138], 'particular': [4140], '30.Sahai': [4146], 'Alberts': [4148, 4166, 4397], 'A.S.': [4149, 4167, 4398], 'Treisman': [4150], '1350-1361Crossref': [4156], '(231)': [4159], '31.Palazzo': [4162], 'A.F.': [4163, 4394], 'Cook': [4164, 4395], 'T.A.': [4165, 4396], 'Gundersen': [4168, 4399], 'G.G.': [4169, 4400], '723-729Crossref': [4175, 4406], '(489)': [4178, 4409], 'RhoAG14V/F39V': [4185], 'mutant,': [4186], '(32.Matsui': [4200], 'Amano': [4202], 'Yamamoto': [4204], 'Chihara': [4206], 'Nakafuku': [4208], 'Ito': [4210], 'Nakano': [4212], 'Okawa': [4214, 4236], 'Iwamatsu': [4216, 4238], 'Kaibuchi': [4218], '1996;': [4222, 4254], '15:': [4223, 4255], '2208-2216Crossref': [4224], '(949)': [4227], '33.Ishizaki': [4230], 'Maekawa': [4232], 'Fujisawa': [4234], 'Fujita': [4240], 'Watanabe': [4242, 4418], 'Saito': [4244, 4422], 'Kakizuka': [4246], 'Morii': [4248], 'Narumiya': [4250, 4426], '1885-1893Crossref': [4256], '(798)': [4259], '34.Leung': [4262], 'Manser': [4264], 'Tan': [4266], 'Lim': [4268], '1995;': [4273], '270:': [4274], '29051-29054Abstract': [4275], '(641)': [4283], 'still': [4287], 'able': [4288], 'overexpressed': [4296], 'macrophages': [4299], 'RhoAG14V/F39A': [4304], 'retains': [4307], 'mDia,': [4312], 'Rho-kinase,': [4315], 'completely': [4316], 'lost': [4317], 'pointed': [4324], '(also': [4327], 'referred': [4328], 'ROK': [4331], 'ROCK)': [4333], 'potential': [4336], 'mediator': [4337, 4377], 'Essentially': [4345], 'results': [4347], 'obtained': [4349], '5C).': [4365], 'primary': [4376], 'Rho-dependent': [4380], 'F39A': [4385], '(31.Palazzo': [4393], '35.Fujisawa': [4412], 'Madaule': [4414], 'Ishizaki': [4416], 'Bito': [4420], '273:': [4432], '18943-18949Abstract': [4433], 'P': [4438]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2011906296', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-28T00:59:42.367974', 'created_date': '2016-06-24'}