Publication Information

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2625, 2682, 2690, 3308, 3346, 3415, 3666, 3845, 3924, 4160, 4171, 4300, 4347, 4866, 4975, 5025, 5224, 5327, 5407, 5420, 5498, 5633, 5711, 5796, 5853, 5881, 5926, 5952, 5981, 6154], 'distinguish': [12, 230], 'the': [13, 19, 48, 71, 80, 90, 95, 160, 167, 190, 231, 237, 266, 289, 298, 308, 313, 378, 385, 408, 571, 665, 693, 716, 779, 1057, 1093, 1114, 1125, 1158, 1290, 1295, 1308, 1311, 1319, 1324, 1399, 1418, 1466, 1495, 1500, 1512, 1527, 1534, 1796, 1799, 1824, 1930, 2000, 2105, 2177, 2190, 2193, 2291, 2332, 2445, 2504, 2723, 2813, 2847, 2854, 2876, 2895, 2905, 2944, 2960, 2963, 3008, 3042, 3049, 3071, 3090, 3100, 3139, 3155, 3158, 3203, 3219, 3235, 3244, 3251, 3265, 3282, 3295, 3323, 3350, 3407, 3432, 3443, 3462, 3485, 3500, 3503, 3565, 3578, 3607, 3612, 3689, 3715, 3735, 3745, 3757, 3770, 3779, 3793, 3806, 3811, 3827, 3837, 3846, 3922, 4039, 4076, 4095, 4144, 4158, 4186, 4191, 4215, 4275, 4302, 4342, 4452, 4476, 4511, 4519, 4527, 4576, 4611, 4696, 4700, 4704, 4708, 4742, 4765, 4777, 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3445, 3450, 3464, 3505, 3528, 3535, 3550, 3562, 3573, 3633, 3680, 3692, 3747, 3766, 3795, 3829, 3848, 3859, 3927, 3941, 4035, 4053, 4070, 4103, 4129, 4190, 4193, 4202, 4233, 4247, 4265, 4269, 4283, 4305, 4313, 4344, 4421, 4464, 4467, 4506, 4514, 4523, 4534, 4556, 4571, 4609, 4699, 4728, 4787, 4804, 4837, 4887, 4956, 4993, 5017, 5060, 5160, 5197, 5208, 5246, 5294, 5306, 5315, 5344, 5522, 5527, 5602, 5627, 5638, 5653, 5695, 5785, 5811, 5819, 5821, 5824, 5833, 5875, 5885, 5894, 5906, 5915, 5931, 5955, 5970, 5975, 5992, 6078, 6089, 6100, 6122, 6128, 6151], 'these': [16, 234, 3451, 4409, 4972], 'on': [18, 236, 1056, 1124, 1157, 1731, 1881, 2275, 2860, 3055, 4137, 4930, 6190], 'regulation': [20, 43, 202, 238, 261, 420, 572, 682, 686, 1059, 1181, 5526, 6099], 'individual': [22, 35, 240, 253, 581, 1732, 4625, 4844, 5651], 'ॖ,': [23, 58, 241, 276, 575, 5227], 'δ,': [24, 59, 242, 277, 574, 2728, 5226], 'and': [25, 60, 98, 243, 278, 316, 440, 448, 522, 533, 576, 859, 874, 1131, 1165, 1286, 1304, 1420, 1425, 1431, 1445, 1459, 1475, 1486, 1502, 1507, 1515, 1521, 1530, 1553, 1570, 1604, 1620, 1743, 1784, 1818, 1892, 1904, 1920, 1933, 1995, 2023, 2047, 2060, 2099, 2197, 2244, 2303, 2345, 2371, 2374, 2399, 2563, 2644, 2713, 2730, 3212, 3328, 3458, 3588, 3701, 3719, 3726, 3731, 3751, 3762, 3786, 3814, 3831, 3850, 4059, 4066, 4088, 4150, 4168, 4325, 4334, 4413, 4480, 4509, 4538, 4542, 4628, 4630, 4643, 4754, 4760, 4768, 4774, 4826, 4883, 4920, 4926, 5027, 5044, 5135, 5145, 5154, 5199, 5228, 5235, 5248, 5539, 5622, 5683, 5713, 6172, 6178, 6185, 6208, 6211], 'κ': [26, 61, 86, 244, 279, 304, 577, 1166, 1245, 1305, 1421, 1444, 1503, 1516, 1994, 2062, 2440, 2453, 2470, 2515, 2533, 2684, 2714, 2939, 3134, 3240, 3272, 3329, 3481, 3529, 3603, 3641, 3702, 3718, 3752, 3802, 4138, 4324, 4335, 4539, 4709, 4789, 4805, 4839, 5028, 5128, 5155, 5229, 5677, 5789, 6199], 'receptors': [27, 38, 69, 87, 120, 137, 151, 180, 245, 256, 287, 305, 338, 355, 369, 398, 443, 513, 689, 721, 777, 877, 1061, 1103, 1168, 1205, 1306, 1347, 1392, 1422, 1517, 1752, 1906, 1998, 2063, 2098, 2329, 2402, 2441, 2454, 2471, 2516, 2534, 2557, 2636, 2685, 2689, 2920, 2940, 3115, 3135, 3189, 3196, 3229, 3241, 3273, 3330, 3354, 3381, 3397, 3429, 3452, 3482, 3530, 3563, 3576, 3604, 3642, 3651, 3703, 3721, 3753, 3768, 3798, 3803, 3853, 3929, 3943, 4037, 4071, 4162, 4175, 4206, 4317, 4336, 4406, 4470, 4516, 4541, 4816, 4865, 5030, 5051, 5129, 5156, 5201, 5230, 5250, 5329, 5424, 5503, 5529, 5541, 5597, 5605, 5631, 5700, 5804, 5835, 5887, 5957, 5979, 6102, 6124, 6161], 'are': [28, 99, 108, 181, 246, 317, 326, 399, 444, 514, 529, 672, 1104, 2686, 2843, 3038, 3673, 4163, 4497, 5031, 5330, 5704, 5857, 5962], 'not': [29, 100, 247, 318, 673, 861, 3375, 3404, 3522, 3674, 3816, 4116, 4221, 4279, 4831, 4934, 4982, 5137, 5815], 'understood.': [30, 248, 674], 'We': [31, 174, 249, 392, 675, 1118, 5022, 6168], 'have': [32, 250, 583, 676, 699, 1053, 1119, 4636, 5023, 5542], 'observed': [33, 251, 585, 2494, 3249, 3292, 3389, 3418, 3629, 3705, 3755, 3835, 4046, 4074, 4944, 5203, 5611], 'cloned': [36, 254, 1243, 1557, 1606, 6198], 'differ': [39, 257, 972, 3707, 5547], 'significantly': [40, 258, 973, 4439, 4736, 5942], 'in': [41, 47, 79, 89, 94, 124, 259, 265, 297, 307, 312, 342, 446, 570, 664, 974, 1090, 1107, 1170, 1198, 1289, 1294, 1307, 1318, 1343, 1398, 1417, 1494, 1563, 1622, 1765, 1772, 1795, 1823, 1885, 1888, 1999, 2021, 2045, 2049, 2104, 2189, 2202, 2206, 2295, 2315, 2331, 2338, 2380, 2444, 2464, 2477, 2495, 2529, 2560, 2638, 2719, 2739, 2807, 2837, 2922, 2943, 2959, 2974, 2985, 2990, 3002, 3032, 3117, 3138, 3154, 3169, 3180, 3202, 3218, 3250, 3261, 3281, 3294, 3322, 3333, 3390, 3394, 3419, 3442, 3461, 3467, 3499, 3540, 3547, 3611, 3630, 3669, 3678, 3688, 3708, 3714, 3734, 3756, 3769, 3778, 3805, 3810, 3836, 3947, 4047, 4079, 4107, 4143, 4148, 4209, 4253, 4274, 4408, 4425, 4441, 4451, 4471, 4499, 4559, 4579, 4758, 4853, 4918, 4950, 4962, 4989, 5006, 5040, 5057, 5062, 5131, 5146, 5193, 5251, 5299, 5309, 5510, 5524, 5548, 5618, 5660, 5664, 5670, 5846, 5859, 5871, 5934, 5944, 5989, 6083, 6096, 6131], 'their': [42, 260, 975, 1757, 2692], 'by': [44, 140, 184, 189, 262, 358, 402, 407, 517, 523, 580, 692, 1113, 1122, 1279, 1405, 1455, 1481, 1545, 1596, 1645, 1673, 1740, 1755, 2005, 2066, 2084, 2113, 2212, 2229, 2293, 2351, 2368, 2457, 2633, 2700, 2831, 2893, 2917, 2937, 3026, 3088, 3112, 3132, 3192, 3225, 3406, 3425, 3455, 3654, 3660, 3676, 3739, 3775, 3783, 3826, 3933, 3959, 4165, 4185, 4197, 4319, 4418, 4588, 4725, 4751, 4841, 4876, 5034, 5046, 5163, 5319, 5332, 5413, 5422, 5530, 5615, 5780, 5840, 5891, 5903, 6105, 6143, 6163], 'rapid': [45, 116, 263, 334, 848, 982, 3459, 3571, 5035, 5244], 'endocytosis': [46, 186, 264, 404, 3385, 3438, 3957, 4232, 4282, 4767, 5532, 5617, 5874, 5961, 6121, 6153], 'presence': [49, 81, 267, 299, 666, 1800, 2191, 3220, 3283, 3296, 3504, 3794, 5059], 'drug': [52, 270], 'etorphine,': [53, 271, 1128, 3222, 3300, 3796, 5061], 'a': [54, 145, 197, 272, 363, 415, 678, 773, 786, 1108, 1129, 1176, 1413, 1489, 1827, 2114, 2117, 2234, 2240, 2257, 2264, 2356, 2991, 3301, 3400, 3456, 3570, 3761, 4058, 4065, 4100, 4311, 4492, 4552, 4712, 4884, 4906, 4946, 4952, 5205, 5219, 5320, 5414, 5511, 5707, 5786, 5809, 5816, 5841, 5907, 5911, 6137, 6149], 'potent': [55, 273, 1130], 'agonist': [56, 192, 274, 410, 1094, 1135, 5223, 5304], 'Internalization': [64, 282], 'epitope-tagged': [66, 284, 1162, 1736, 2328, 2396, 2514, 2634, 2683, 2711, 3187, 3574, 3640], 'δ': [67, 119, 285, 337, 873, 1164, 1203, 1303, 1313, 1419, 1446, 1501, 1514, 1528, 1997, 2018, 2398, 2635, 2712, 3195, 3270, 3327, 3428, 3575, 3650, 3700, 3720, 3750, 3797, 3849, 3942, 4036, 4104, 4161, 4204, 4326, 4333, 4536, 4701, 4743, 4810, 4847, 4860, 4894, 4915, 4958, 5000, 5026, 5050, 5153, 5198, 5247, 5672, 5688, 5777], 'from': [70, 288, 778, 1511, 1526, 2290, 2853, 2967, 3048, 3162, 3516, 3564, 3577, 4038, 4584, 4707, 4858, 4998, 5302, 5339, 5686, 5775, 5964], 'plasma': [72, 96, 290, 314, 780, 2333, 3204, 3252, 3566, 3579, 3613, 3758, 3812, 4040, 4145, 5133], 'membrane': [73, 97, 291, 315, 781, 1159, 2724, 3205, 3253, 3614, 3709, 3759, 3813, 4041, 4146, 5134, 5195, 5607, 5831, 5883], 'is': [74, 121, 138, 292, 339, 356, 712, 770, 860, 2545, 2622, 3773, 3854, 4548, 4582, 4979, 5218, 5411, 5643, 5690, 5805], 'detectable': [75, 293, 3267, 3617], 'within': [76, 294, 722, 853, 3215, 3585, 4240, 4633, 5054, 5716], '10': [77, 295, 1816, 3520, 3593], 'min': [78, 296, 1779, 2188, 2325, 3280, 3497, 3534, 3594, 3621, 4242], 'etorphine.': [83, 114, 301, 332, 2701], 'In': [84, 302, 2618, 3369, 3477, 3600, 3744, 3792, 4126, 4219, 5126], 'contrast,': [85, 303, 3478, 3601, 4127, 5127], 'expressed': [88, 306, 519, 1169, 2637, 2921, 3116], 'same': [91, 191, 309, 409, 694, 1115, 1296, 1309, 1535, 1931, 2001, 2106, 2446, 2945, 3140, 3245, 3486, 3608, 3716, 3736, 3771, 3807, 4077, 4187, 4276, 5042, 5048, 5143, 5148, 5253, 6165], 'cells': [92, 107, 125, 310, 325, 343, 1613, 1653, 1717, 1728, 1770, 1878, 2002, 2009, 2041, 2182, 2199, 2273, 2287, 2305, 2367, 2479, 2497, 2530, 2640, 2811, 2926, 2951, 3006, 3121, 3146, 3208, 3256, 3338, 3392, 3395, 3468, 3479, 3553, 3738, 3772, 3808, 3948, 4048, 4080, 4108, 4115, 4152, 4213, 4220, 4254, 4428, 4474, 4483, 4508, 4560, 4763, 4923, 5043, 5254], 'remain': [93, 311], 'internalized': [101, 319, 1106, 3214, 4164, 5053, 5138], 'for': [102, 320, 1561, 1609, 1777, 2186, 2323, 2522, 2551, 2626, 2707, 2839, 2870, 2913, 2933, 3034, 3065, 3108, 3128, 3349, 3495, 3619, 4526, 4566, 5692, 5959, 5967, 6092, 6145, 6175, 6188, 6195, 6204, 6214], '≥60': [103, 321], 'min,': [104, 322, 1817], 'even': [105, 323, 663, 3277, 3293, 3531, 3711, 4791, 4909, 5037, 5150, 5215], 'when': [106, 324, 2480, 3493, 3712, 5038, 5139], 'exposed': [109, 327, 2481, 3469], 'to': [110, 328, 714, 782, 871, 977, 1092, 1412, 1449, 1464, 1759, 1791, 1805, 2015, 2054, 2093, 2176, 2284, 2326, 2340, 2377, 2482, 2547, 2624, 2694, 3230, 3264, 3275, 3310, 3345, 3470, 3519, 3525, 3558, 3646, 3706, 3818, 3856, 4042, 4444, 4591, 4595, 4639, 4783, 4819, 4833, 4905, 4936, 4985, 5003, 5013, 5165, 5240, 5419, 5546, 5612, 5807, 5866, 5940, 6116], 'saturating': [111, 329, 2483, 3302], 'concentrations': [112, 330, 2484, 3514], 'The': [115, 333, 1242, 1443, 1746, 2448, 2520, 2822, 2911, 2931, 2956, 3017, 3106, 3126, 3151, 3183, 4431, 4532, 4569, 4607, 4871, 5312, 5493, 6133], 'internalization': [117, 134, 335, 352, 983, 3268, 3290, 3325, 3379, 3449, 3527, 3543, 3618, 3672, 3847, 3926, 3940, 4069, 4106, 4196, 4201, 4460, 4466, 4513, 4524, 4558, 4573, 4587, 4642, 4739, 4786, 4823, 4836, 4904, 4932, 4941, 4992, 5016, 5245, 5297, 5307, 5317, 5410, 5550, 5694, 5784, 5823, 5933, 5983, 6081], 'specifically': [122, 340, 3424, 3955], 'inhibited': [123, 341, 2473, 3946], 'expressing': [126, 344, 1735, 2531, 2562, 2812, 2952, 3007, 3147, 3396, 3480, 3639, 3949, 4049, 4081, 4109, 4255], 'K44E': [127, 345, 1571, 3950, 4054, 4110, 4198, 4256], 'mutant': [128, 149, 346, 367, 1163, 1389, 1572, 1750, 2732, 3951, 4055, 4111, 4119, 4132, 4199, 4224, 4257, 4315, 4405, 4469, 4515, 4528, 4545, 4714, 4815, 4864, 4900, 4948, 5019, 5322, 5629, 5788, 5924], 'dynamin': [129, 347, 1573, 2101, 3952, 4056, 4083, 4112, 4120, 4123, 4133, 4225, 4258, 4260, 4272, 4286, 5323, 6206], 'I,': [130, 348, 2499, 2539, 3953], 'suggesting': [131, 349, 1048, 3921], 'type-specific': [133, 204, 351, 422, 685, 1109, 1184, 3320, 3667, 3925, 5512, 5623, 5662, 5869, 6094, 6120], 'mediated': [139, 357, 2632, 2916, 2936, 3111, 3131, 3423, 3436, 3932, 3958, 5412], 'clathrin-coated': [141, 359, 3934, 3960, 4166, 4181, 5333], 'pits.': [142, 360, 3935, 5334], 'Examination': [143, 361, 2502, 4463], 'series': [146, 364, 4312], 'chimeric': [148, 366, 2731, 4314, 4404, 4468, 4544, 4713, 4814, 4863, 4899, 4947, 5018, 5628, 5697, 5923], 'κ/δ': [150, 368, 4529, 5630, 5698], 'indicates': [152, 370, 5632], 'at': [154, 372, 564, 1540, 1636, 2278, 2861, 2880, 2978, 3056, 3075, 3173, 3512, 3643], 'least': [155, 373, 2862, 3057], 'two': [156, 374, 2863, 3058], 'receptor': [157, 201, 375, 419, 563, 681, 857, 1180, 1197, 1247, 1315, 1529, 1666, 2346, 2383, 2815, 2872, 3010, 3067, 3426, 3542, 3656, 3671, 3681, 3695, 4105, 4195, 4266, 4298, 4307, 4547, 4557, 4572, 4641, 4702, 4710, 4715, 4806, 4840, 4861, 4889, 4901, 4931, 4949, 4959, 5001, 5296, 5409, 5640, 5665, 5673, 5689, 5720, 5778, 5790, 5848, 5900, 5919, 5925, 6080, 6152], 'domains,': [158, 376], 'including': [159, 377, 3637, 5211], 'highly': [161, 379, 5415], 'divergent': [162, 380, 1467, 5855], 'carboxyl-terminal': [163, 381, 1400, 4612, 4851, 4880, 4966, 5010, 5635, 5800, 5863], 'cytoplasmic': [164, 382, 710, 1401, 4613, 4620, 4881, 5011, 5636, 5801, 5864], 'tail,': [165, 383, 5012], 'determine': [166, 384, 4301, 5868], 'type': [168, 214, 386, 432, 560, 4303, 5292], 'specificity': [169, 387, 4304, 5293], 'this': [171, 389, 660, 979, 1097, 1121, 1450, 1462, 1470, 2508, 2620, 3420, 3698, 3937, 4619, 4634, 4793, 4937, 5300, 5316, 5668, 5684, 5717, 5773, 6141], 'endocytic': [172, 390, 849, 1098, 3690, 4238], 'mechanism.': [173, 391], 'conclude': [175, 393], 'structurally': [177, 395, 524, 1100, 3693, 4172, 5500, 5536, 6158], 'homologous': [178, 396, 437, 1101, 3694, 4173, 5501, 5537, 6159], 'differentially': [182, 400, 1105, 4178, 5032, 6156], 'sorted': [183, 401, 4179, 5506], 'clathrin-mediated': [185, 403, 5531], 'following': [187, 405, 690, 1111, 4183, 5514, 6103], 'activation': [188, 406, 691, 725, 858, 1112, 2553, 2708, 4184, 5969, 6104], 'ligand.': [193, 411], 'These': [194, 412, 512, 1173, 2679, 3663, 4090, 4155, 4328, 4495, 5516, 5702, 5793, 5878], 'studies': [195, 413, 698, 1344, 2721, 3843, 4329, 4410, 5066, 5340, 5936, 6112, 6135], 'identify': [196, 414, 1175, 4297], 'fundamental': [198, 416, 1177], 'mechanism': [199, 417, 679, 1178, 5417, 6150], 'mediating': [203, 421, 5661], 'effects': [205, 423, 1055, 1126, 1185], 'analgesic': [207, 425, 970, 6109], 'more': [211, 429, 557, 787, 5916], 'than': [212, 430, 558, 3307, 3649, 5917], 'one': [213, 431, 559, 5918], 'receptor.': [217, 435, 4744], 'Structurally': [436], 'ॖ-,': [438], 'δ-,': [439], 'κ-type': [441], 'conserved': [445, 1414, 1490, 5416, 5644], 'mammals': [447], 'signal': [449], 'via': [450, 5946], 'similar': [451, 2088, 2546, 2623, 3344, 4488, 4907, 5166, 5418], 'heterotrimeric': [452, 5167, 5971], 'G': [453, 5168, 5603, 5972, 5977], 'proteins': [454, 5169, 5897], '(1Evans': [455], 'C.J.': [456, 891, 950, 997, 1222, 1693, 1854, 1953, 2134, 2419, 2659, 3875, 3902, 4652, 5080, 5107, 5268, 5360, 5387, 5729], 'Korenman': [457], 'S.G.': [458, 5470], 'Barchas': [459], 'J.D.': [460], 'Biological': [461], 'Basis': [462], 'Substance': [464], 'Abuse.': [465], 'Oxford': [466], 'University': [467], 'Press,': [468], 'New': [469, 1437, 1917], 'York1993:': [470], '31-48Google': [471], 'Scholar,': [472, 485, 614, 634, 740, 802, 820, 910, 942, 1364, 1972, 2153, 2578, 2596, 3894, 3980, 4005, 4374, 4670, 5099, 5379, 5441, 5466, 5573, 5747, 6008, 6021, 6049], '2Kieffer': [473], 'B.L.': [474, 729], 'Cell.': [475], 'Mol.': [476, 625, 734, 797, 1150, 2573, 2611, 6015], 'Neurobiol.': [477], '1995;': [478, 736, 761, 4024, 4390, 6017], '15:': [479, 762], '615-635Crossref': [480], 'PubMed': [481, 547, 610, 630, 764, 818, 906, 938, 964, 1012, 1043, 1081, 1237, 1272, 1362, 1385, 1589, 1708, 1869, 1968, 1987, 2149, 2168, 2434, 2594, 2674, 3890, 3916, 3976, 4001, 4027, 4370, 4398, 4666, 4690, 5095, 5121, 5186, 5283, 5375, 5401, 5439, 5462, 5488, 5571, 5593, 5743, 5767, 6006, 6045, 6069], 'Scopus': [482, 548, 611, 631, 907, 939, 965, 1013, 1044, 1082, 1238, 1273, 1590, 1709, 1870, 1969, 2150, 2435, 2675, 3891, 3917, 3977, 4002, 4028, 4371, 4399, 4667, 4691, 5096, 5122, 5187, 5284, 5376, 5402, 5463, 5489, 5744, 5768, 6046, 6070], '(349)': [483], 'Google': [484, 550, 613, 633, 739, 765, 819, 844, 909, 941, 967, 1015, 1046, 1084, 1155, 1240, 1275, 1363, 1386, 1592, 1711, 1872, 1971, 1988, 2152, 2169, 2437, 2595, 2616, 2677, 3367, 3893, 3919, 3979, 4004, 4030, 4373, 4401, 4669, 4693, 5098, 5124, 5189, 5286, 5378, 5404, 5440, 5465, 5491, 5572, 5594, 5746, 5770, 6007, 6020, 6048, 6072], '3Raynor': [486], 'K.': [487, 587, 589, 822, 832, 1137, 1143, 1249, 1251, 2598, 2604, 4013, 5577], 'Kong': [488, 590, 823, 827, 1138, 1252, 2599], 'H.': [489, 591, 636, 756, 824, 1139, 1253, 2600, 3988, 4009, 4386, 5575, 5581], 'Law': [490, 5172], 'S.': [491, 605, 646, 933, 948, 1038, 1267, 1550, 3356, 3900, 4650, 4672, 5105, 5385, 5727, 5749, 6010, 6012], 'Heerding': [492], 'J.': [493, 499, 538, 595, 754, 759, 809, 826, 830, 837, 895, 953, 1001, 1070, 1226, 1257, 1353, 1376, 1583, 1697, 1858, 1957, 1978, 2138, 2159, 2423, 2585, 2663, 3879, 3905, 3970, 3995, 4387, 4655, 4679, 5084, 5110, 5272, 5364, 5390, 5430, 5468, 5477, 5562, 5584, 5732, 5756, 6034, 6058], 'Tallent': [494, 5176], 'M.': [495, 752, 894, 914, 923, 1000, 1019, 1028, 1225, 1350, 1367, 1696, 1857, 1956, 1975, 2137, 2156, 2422, 2662, 3361, 3878, 5083, 5177, 5271, 5363, 5427, 5553], 'Livingston': [496], 'F.': [497, 638, 4376, 5447], 'Hines': [498, 825], 'Reisine': [500, 596, 835, 1068, 1148, 1258, 1282, 2609, 4360, 6194], 'T.': [501, 597, 836, 1069, 1149, 1259, 2610, 4007, 4361, 5171, 5579, 5583], 'Natl.': [502, 601, 647, 929, 1034, 1263], 'Inst.': [503, 648], 'Drug': [504, 649], 'Abuse': [505, 650], 'Res.': [506, 651, 6002], 'Monogr.': [507, 652], '1996;': [508, 653, 898, 935, 956, 1004, 1040, 1229, 1700, 1861, 1960, 2141, 2426, 2666, 3364, 3882, 3908, 4364, 4658, 4682, 5087, 5113, 5183, 5275, 5367, 5393, 5459, 5480, 5735, 5759, 6037], '161:': [509, 654], '83-103Google': [510], 'Scholar).': [511, 551, 656, 766, 845, 968, 1085, 1241, 1387, 1712, 1873, 1989, 2170, 2438, 2617, 2678, 3368, 4031, 4402, 4694, 5125, 5190, 5287, 5492, 5771, 6073], 'activated': [515, 2696, 5045, 6162], 'both': [516, 2559, 2710, 3749, 3767, 4147, 4757, 4878, 4917, 5152, 5619], 'endogenously': [518], 'peptides': [521], 'distinct': [525], 'agonists,': [527], 'which': [528, 769, 851, 2881, 2975, 3076, 3170, 3581, 3954, 4141, 4437, 4501, 4720, 4734, 4951, 5642], 'clinically': [530, 565], 'important': [531, 5658, 5987], 'abuse': [536], '(4Hughes': [537], 'Kosterlitz': [539], 'H.W.': [540], 'Br.': [541], 'Med.': [542], 'Bull.': [543], '1977;': [544], '33:': [545], '157-161Crossref': [546], '(54)': [549], 'Although': [552, 4828, 5535], 'many': [553], 'relevant': [566], 'concentrations,': [567, 5210, 5214], 'significant': [568, 4821, 4868, 6138], 'differences': [569, 3539, 3668, 3677, 3687, 4988, 5192, 5663, 5870, 6095], 'receptor-mediated': [578, 3312, 4231, 4281], 'processes': [579, 702], 'agonists': [582], 'been': [584, 868, 2074, 4637, 5237, 5543, 5610], '(5Yasuda': [586, 1248], 'Raynor': [588, 1250], 'Breder': [592, 1254], 'C.D.': [593, 1255], 'Takeda': [594, 1256], 'Bell': [598, 833, 1146, 1260, 2607], 'G.I.': [599, 834, 1147, 1261, 2608], 'Proc.': [600, 928, 1033, 1262], 'Acad.': [602, 930, 1035, 1264, 5181], 'Sci.': [603, 931, 1036, 1265, 5182], 'U.': [604, 932, 1037, 1266, 1549], 'A.': [606, 640, 742, 934, 1039, 1268, 5175], '1993;': [607, 1269, 1379, 1586, 3973, 3998, 5565, 6003], '90:': [608, 1270], '6736-6740Crossref': [609, 1271], '(609)': [612, 1274], '6Law': [615], 'P.Y.': [616], 'McGinn': [617], 'T.M.': [618], 'Campbell': [619, 747], 'K.M.': [620, 6051], 'Erickson': [621], 'L.E.': [622], 'Loh': [623, 795, 807, 2571, 2583], 'H.H.': [624, 796, 808, 2572, 2584], 'Pharmacol.': [626, 735, 798, 838, 1151, 2574, 2612, 6016], '1997;': [627, 1073, 6061], '51:': [628], '152-160Crossref': [629], '(27)': [632], '7Akil': [635], 'Meng': [637], 'Mansour': [639], 'Thompson': [641, 4379], 'R.': [642, 1369, 5555], 'Xie': [643], 'G.X.': [644], 'Watson': [645, 4383], '127-140Google': [655], 'Molecular': [657], 'mechanisms': [658], 'underlying': [659], 'functional': [661, 717, 1747, 2449, 2687, 4345, 4722, 4797, 4813, 5787], 'specificity,': [662], 'relatively': [668, 1132, 1187, 4349, 5220, 6106], 'nonselective': [669, 1133, 1188, 4350, 5221, 6107], 'opiate': [670, 1050, 1134, 1189, 6108], 'drugs,': [671], 'identified': [677, 700], 'mediates': [684, 1183], 'agonist.': [696, 1117, 5049, 6167], 'Previous': [697, 3842], 'regulate': [704, 872, 6157], 'Ligand-dependent': [707], 'phosphorylation': [708], 'residues': [711], 'thought': [713], 'modulate': [715], 'activity': [718, 2450], 'minutes': [723, 855, 3217, 3587, 5056], 'after': [724, 856, 1722, 1815, 3278, 3532], '(8Pei': [726], 'G.': [727, 828, 1065, 1373, 4359, 5559, 6029], 'Kieffer': [728], 'Lefkowitz': [730, 5997, 6056], 'R.J.': [731, 5998, 6057], 'Freedman': [732], 'N.J.': [733], '48:': [737, 6004], '173-177PubMed': [738], '9Mestek': [741], 'Hurley': [743], 'J.H.': [744, 5455], 'Bye': [745], 'L.S.': [746, 5472], 'A.D.': [748, 1063, 4357], 'Chen': [749, 1140, 2601], 'Y.': [750, 1141, 2602, 5180, 6053], 'Tian': [751], 'Liu': [753], 'Schulman': [755], 'Yu': [757, 1144, 2605], 'L.': [758, 889, 995, 1145, 1220, 1691, 1852, 1951, 2132, 2417, 2606, 2657, 3873, 4382, 5078, 5266, 5358, 5474], 'Neurosci.': [760], '2396-2406Crossref': [763], 'Agonist-induced': [767], 'down-regulation,': [768], 'associated': [771, 862], 'with': [772, 863, 1323, 1628, 1725, 1780, 1812, 2010, 2028, 2068, 2077, 2216, 2239, 2263, 2308, 2517, 2697, 3198, 3399, 3431, 3484, 3590, 3724, 4062, 4114, 4118, 4223, 4551, 4562, 4703, 4741, 4807, 4846, 4855, 4891, 4945, 4964, 5008, 5064, 5231, 5674, 5706, 5861, 5898, 5910, 6180], 'gradual': [774], 'translocation': [775, 3226], 'lysosomes,': [783], 'occurs': [784, 852], 'over': [785, 5204], 'prolonged': [788], 'time': [789], 'course': [790], '(10Law': [791, 2567], 'P.-Y.': [792, 804, 2568, 2580], 'Hom': [793, 805, 2569, 2581], 'D.S.': [794, 806, 2570, 2582], '1982;': [799, 2575], '72:': [800, 2576], '1-4Google': [801, 2577], '11Law': [803, 2579], 'Biol.': [810, 896, 954, 1002, 1071, 1227, 1354, 1377, 1585, 1698, 1859, 1958, 1979, 2139, 2160, 2424, 2586, 2664, 3880, 3906, 3972, 3997, 4023, 4363, 4388, 4656, 4680, 5085, 5111, 5273, 5365, 5391, 5431, 5478, 5563, 5585, 5733, 5757, 6035, 6059], 'Chem.': [811, 897, 955, 1003, 1072, 1228, 1355, 1378, 1699, 1860, 1959, 1980, 2140, 2161, 2425, 2587, 2665, 3881, 3907, 4362, 4389, 4657, 4681, 5086, 5112, 5274, 5366, 5392, 5432, 5479, 5564, 5586, 5734, 5758, 6036, 6060], '1984;': [812, 2588], '259:': [813, 2589], '4096-4104Abstract': [814, 2590], 'Full': [815, 901, 903, 959, 961, 1007, 1009, 1076, 1078, 1232, 1234, 1359, 1382, 1703, 1705, 1864, 1866, 1963, 1965, 1984, 2144, 2146, 2165, 2429, 2431, 2591, 2669, 2671, 3885, 3887, 3911, 3913, 4367, 4393, 4395, 4661, 4663, 4685, 4687, 5090, 5092, 5116, 5118, 5278, 5280, 5370, 5372, 5396, 5398, 5436, 5483, 5485, 5568, 5590, 5738, 5740, 5762, 5764, 6040, 6042, 6064, 6066], 'Text': [816, 902, 904, 960, 962, 1008, 1010, 1077, 1079, 1233, 1235, 1360, 1383, 1704, 1706, 1865, 1867, 1964, 1966, 1985, 2145, 2147, 2166, 2430, 2432, 2592, 2670, 2672, 3886, 3888, 3912, 3914, 4368, 4394, 4396, 4662, 4664, 4686, 4688, 5091, 5093, 5117, 5119, 5279, 5281, 5371, 5373, 5397, 5399, 5437, 5484, 5486, 5569, 5591, 5739, 5741, 5763, 5765, 6041, 6043, 6065, 6067], 'PDF': [817, 905, 963, 1011, 1080, 1236, 1361, 1384, 1707, 1868, 1967, 1986, 2148, 2167, 2433, 2593, 2673, 3889, 3915, 4369, 4397, 4665, 4689, 5094, 5120, 5282, 5374, 5400, 5438, 5487, 5570, 5592, 5742, 5766, 6044, 6068], '12Raynor': [821], 'Benovic': [829, 5456], 'Yasuda': [831, 1142, 2603], 'Exp.': [839], 'Ther.': [840], '1994;': [841, 1152, 2162, 2613, 5433, 5587], '270:': [842, 4391], '1381-1386PubMed': [843], 'A': [846, 2087], 'distinguishable': [847, 5963], 'process,': [850], 'several': [854, 3216, 3586, 5055], 'degradation': [864], 'receptors,': [866, 1737, 2019, 2715, 3271, 4140, 4627], 'has': [867, 5236, 5609], 'shown': [869, 5024, 5238, 5544], 'recently': [870], 'ॖ': [875, 2400, 3851, 5200, 5249], '(13Keith': [878, 984, 1209, 1680, 1841, 1940, 2121, 2406, 3862, 5067, 5255, 5347], 'D.E.': [879, 946, 985, 1210, 1681, 1842, 1941, 2122, 2407, 2647, 3863, 3898, 4017, 4648, 5068, 5103, 5256, 5348, 5383, 5725], 'Murray': [880, 986, 1211, 1682, 1843, 1942, 2123, 2408, 2648, 3864, 5069, 5257, 5349], 'S.R.': [881, 987, 1212, 1683, 1844, 1943, 2124, 2409, 2649, 3865, 5070, 5258, 5350], 'Zaki': [882, 988, 1213, 1684, 1845, 1944, 2125, 2410, 2650, 3866, 5071, 5259, 5351], 'P.A.': [883, 989, 1214, 1685, 1846, 1945, 2126, 2411, 2651, 3867, 5072, 5260, 5352], 'Chu': [884, 990, 1215, 1686, 1847, 1946, 2127, 2412, 2652, 3868, 5073, 5261, 5353], 'P.C.': [885, 991, 1216, 1687, 1848, 1947, 2128, 2413, 2653, 3869, 5074, 5262, 5354], 'Lissin': [886, 992, 1217, 1688, 1849, 1948, 2129, 2414, 2654, 3870, 5075, 5263, 5355], 'D.V.': [887, 993, 1218, 1689, 1850, 1949, 2130, 2415, 2655, 3871, 5076, 5264, 5356], 'Kang': [888, 994, 1219, 1690, 1851, 1950, 2131, 2416, 2656, 3872, 5077, 5265, 5357], 'Evans': [890, 924, 949, 996, 1029, 1221, 1692, 1853, 1952, 2133, 2418, 2658, 3874, 3901, 4651, 5079, 5106, 5267, 5359, 5386, 5728, 6210], 'von': [892, 921, 998, 1026, 1223, 1694, 1855, 1954, 2135, 2420, 2660, 3359, 3876, 5081, 5269, 5361], 'Zastrow': [893, 922, 999, 1027, 1224, 1349, 1366, 1695, 1856, 1955, 1974, 2136, 2155, 2421, 2661, 3360, 3877, 5082, 5270, 5362, 5426, 5552], '271:': [899, 957, 1005, 1230, 1701, 1862, 1961, 2142, 2427, 2667, 3883, 3909, 4659, 4683, 5088, 5114, 5276, 5368, 5394, 5481, 5736, 5760, 6038], '19021-19024Abstract': [900, 1006, 1231, 1702, 1863, 1962, 2143, 2428, 2668, 3884, 5089, 5277, 5369], '(480)': [908, 1014, 1239, 1710, 1871, 1970, 2151, 2436, 2676, 3892, 5097, 5285, 5377], '14Sternini': [911], 'C.': [912, 925, 1017, 1030, 4676, 5753], 'Spann': [913, 1018], 'Anton': [915, 1020], 'B.': [916, 1021, 1375, 5561], 'Keith': [917, 945, 1022, 3897, 4647, 5102, 5382, 5724, 6213], 'D.J.': [918, 1023], 'Bunnett': [919, 1024, 6032, 6171], 'N.W.': [920, 1025, 6033], 'Brecha': [926, 1031], 'N.C.': [927, 1032], '93:': [936, 1041], '9241-9246Crossref': [937, 1042], '(284)': [940, 1045], '15Trapaidze': [943, 3895, 5100, 5380], 'N.': [944, 3896, 4646, 4674, 5101, 5179, 5381, 5723, 5751], 'Cvejic': [947, 3899, 4649, 5104, 5384, 5726], 'Devi': [951, 3903, 4653, 4677, 5108, 5388, 5730, 5754], 'L.A.': [952, 3904, 4654, 4678, 5109, 5389, 5731, 5755], '29279-29285Abstract': [958, 3910, 4660, 5115, 5395, 5737], '(152)': [966, 3918, 4668, 5123, 5403, 5745], 'Individual': [969], 'ability': [976, 1758, 2693, 4443], 'stimulate': [978, 1792, 3526, 5242], 'process': [980, 5318], 'Scholar,14Sternini': [1016], 'Scholar),': [1047, 1156, 3920, 5405, 5595], 'can': [1052, 4176, 5504, 5984, 6155], 'agonist-selective': [1054, 5621], 'physiological': [1058, 6098], '(16Blake': [1062], 'Bot': [1064, 4358], 'Freeman': [1066], 'J.C.': [1067], '272:': [1074, 6062], '782-790Abstract': [1075], '(121)': [1083], 'Here': [1086], 'we': [1087, 4309], 'show': [1088], 'that,': [1089], 'addition': [1091], 'selectivity': [1095, 5305, 6077, 6127], 'mechanism,': [1099], 'manner': [1110, 2946, 3141, 4277, 5513], 'established': [1120], 'focusing': [1123], '(17Raynor': [1136], '45:': [1153, 2614], '330-334PubMed': [1154, 2615], 'trafficking': [1160, 2725, 3710, 5196, 5608, 5721, 5832, 5884], 'transfected': [1171, 1644, 1652, 1716, 1727, 1769, 2465, 2478, 2564, 2740, 2809, 2867, 2924, 2949, 3004, 3062, 3119, 3144, 3337, 3552, 3635, 3737, 4117, 4211, 4222, 4427, 4473, 4482, 4762, 4922], 'cells.': [1172, 1565, 1767, 2107, 2468, 3717], 'observations': [1174, 2680, 3664, 4091, 5794, 5879], 'types': [1194, 2566, 5652], 'vivo.': [1199, 6132], 'Construction': [1200], 'FLAG-tagged': [1202, 1903, 1993, 2061, 2096, 2532, 2918, 2938, 2953, 3113, 3133, 3148, 4203, 4535], 'was': [1206, 1277, 1287, 1316, 1479, 1524, 1753, 1789, 1821, 1907, 2003, 2091, 2174, 2210, 2254, 2349, 2403, 2455, 2493, 2535, 2717, 2805, 2835, 2888, 2891, 2927, 2941, 2983, 3000, 3030, 3083, 3086, 3122, 3136, 3178, 3190, 3291, 3331, 3388, 3422, 3453, 3944, 4045, 4072, 4207, 4249, 4434, 4438, 4449, 4615, 4721, 4748, 4755, 4795, 4830, 4874, 4933, 4942, 4960], 'reported': [1207, 2404, 2549, 2928, 3123, 4638, 5308], 'previously': [1208, 1342, 1679, 1840, 1939, 2120, 2405, 2550, 2929, 3124, 3348, 5239, 5545], 'murine': [1244, 1312, 2397], 'Scholar)': [1276, 1593], 'provided': [1278, 1595], 'Dr.': [1280, 1597], 'Terry': [1281, 6193], '(University': [1283, 1633], 'Pennsylvania)': [1285], 'tagged': [1288, 1317, 2452, 3197, 3398, 3430, 3483, 3723], 'amino-terminal': [1291, 1320], 'extracellular': [1292, 1321, 1497], 'domain': [1293, 1322, 1402, 1498, 4621, 4635, 4845, 4882, 4955, 5637, 5669, 5685, 5718, 5774, 5802, 5865], 'manner.': [1297, 2447, 5624], 'For': [1298, 1874], 'experiments': [1299, 2110], 'involving': [1300], 'co-expression': [1301], 'cells,': [1310, 3636, 5149], 'HA': [1325, 3727], '1The': [1326], 'abbreviations': [1327], 'are:': [1329], 'HA,': [1330], 'hemagglutinin;': [1331], 'Cr.,': [1332], 'chimera;': [1333], 'PBS,': [1334, 2022], 'phosphate-buffered': [1335, 1889], 'saline.': [1336], 'epitope': [1337, 3402, 3435, 3487, 3728], '(YPYDVPDYA),': [1338], 'exactly': [1339], 'described': [1341, 1678, 1839, 1938, 2119, 2818, 3013], 'adrenergic': [1346, 3353, 5423, 5538], '(18von': [1348], 'Kobilka': [1351, 1374, 1976, 2157, 3357, 5428, 5560], 'B.K.': [1352, 1977, 2158, 3358, 5429], '1992;': [1356, 1981], '267:': [1357, 1982], '3530-3538Abstract': [1358, 1983], '19von': [1365], 'Link': [1368, 5554], 'Daunt': [1370, 5556], 'D.': [1371, 5557], 'Barsh': [1372, 5558], '268:': [1380, 5566], '763-766Abstract': [1381, 5567], 'Chimeric': [1388], 'δ/κ': [1390], 'were': [1393, 1403, 1453, 1509, 1543, 1556, 1594, 1605, 1618, 1643, 1654, 1668, 1718, 1729, 1775, 1810, 1879, 2042, 2064, 2111, 2183, 2200, 2227, 2282, 2288, 2306, 2336, 2386, 2442, 3213, 3247, 3544, 3628, 3704, 3722, 3754, 3799, 3815, 4092, 4330, 4414, 5052, 5136, 5202], 'constructed': [1394, 1480, 1510, 1525, 2443, 4318], 'follows.': [1396], 'Exchanges': [1397], 'accomplished': [1404], 'engineering': [1406], 'an': [1407, 3340, 4050, 5519, 5620, 5657], 'EcoRV': [1408], 'site': [1409, 1463, 1492], 'immediately': [1410], 'distal': [1411, 1448], 'cysteine': [1415, 1451], 'residue': [1416, 1452], '(residues': [1423], '328': [1424], '340,': [1426], 'respectively)': [1427], 'using': [1428, 1488, 1518, 1533, 1656, 1714, 1826, 1894, 1909, 1929, 2233, 2256, 2355, 2388, 2904, 2947, 3099, 3142, 3339, 3554, 4094, 4214, 4518, 4575, 4764, 5341], 'synthetic': [1429], 'oligonucleotides': [1430], 'polymerase': [1432, 1456], 'chain': [1433, 1457], 'reaction': [1434, 1458], '(Vent': [1435], 'polymerase,': [1436], 'England': [1438], 'Biolabs)': [1439], 'under': [1440, 2819, 3014, 3243, 3606, 4075, 5141], 'standard': [1441, 2085, 2245], 'conditions.': [1442], 'sequences': [1447, 1538, 4322], 'amplified': [1454], 'fused': [1460], 'into': [1461, 1558, 1607, 4180, 4236, 5507], 'exchange': [1465, 1482], 'portions': [1468, 4803], 'domain,': [1471], 'creating': [1472], 'Crs.': [1473, 1484, 1505], '1': [1474, 1485, 1781, 2300, 3210, 3238, 3258, 3287, 3517], '2.': [1476], 'Cr.': [1477, 1522, 1531, 4435], '3': [1478, 3790, 4825], 'between': [1483, 1670, 4323, 4624, 5650, 5803], '2': [1487, 1532, 3411, 3473, 3596, 3623], 'BglII': [1491], 'located': [1493, 3233], 'third': [1496], '4': [1506, 2285], '5': [1508, 1786, 1802, 2832, 3027, 3298, 4563], 'wild-type': [1513, 1569, 2555, 4082, 4122, 4130, 4270, 4914], 'thisBglII': [1519], 'site,': [1520], '6': [1523, 4581, 4773, 4925], 'approach.': [1536], 'Mutant': [1537], 'produced': [1539, 3782], 'each': [1541, 2840, 2871, 2979, 3035, 3066, 3174, 4543], 'step': [1542], 'verified': [1544], 'dideoxynucleotide': [1546], 'sequencing': [1547], '(Sequenase,': [1548], 'Biochemical': [1551], 'Corp.),': [1552], 'completed': [1554], 'cDNAs': [1555, 1566], 'pcDNA3': [1559, 1608], '(Invitrogen)': [1560], 'expression': [1562, 1667, 2394, 3682], 'mammalian': [1564], 'encoding': [1567], 'HA-tagged': [1568, 1905, 1996, 2017, 2100, 4051], 'I': [1574, 4084, 4124, 4273], '(20Herskovits': [1575, 3962], 'J.S.': [1576, 3963], 'Burgess': [1577, 3964], 'C.C.': [1578, 3965], 'Obar': [1579, 3966], 'R.A.': [1580, 3967], 'Vallee': [1581, 1599, 3968, 6203], 'R.B.': [1582, 3969, 5451], 'Cell': [1584, 1639, 3971, 3996], '122:': [1587, 3974, 3999], '565-578Crossref': [1588, 3975], '(394)': [1591, 3978], 'Richard': [1598, 6202], '(Worcester': [1600], 'Institute,': [1601], 'Shrewsbury,': [1602], 'MA)': [1603], 'expression.': [1610], 'Human': [1611], '293': [1612, 2467, 2639, 2741, 2810, 2925, 2950, 3005, 3120, 3145, 4212], '(American': [1614], 'Type': [1615], 'Culture': [1616, 1640], 'Collection)': [1617], 'maintained': [1619], 'passaged': [1621], "Dulbecco's": [1623], 'modified': [1624], "Eagle's": [1625], 'medium': [1626, 2179, 2317], 'supplemented': [1627], '107': [1629, 2050, 2319], 'fetal': [1630, 2320], 'bovine': [1631, 2321], 'serum': [1632, 2053, 2322], 'California': [1635], 'San': [1637], 'Francisco': [1638], 'Facility).': [1641], 'Cells': [1642, 1809, 2335], 'calcium': [1646], 'phosphate': [1647], 'precipitation.': [1648], 'Clones': [1649], 'stably': [1651, 1726, 2808, 2866, 2923, 2948, 3003, 3061, 3118, 3143, 3551, 3634, 4210, 4426, 4481, 4761, 4921], 'selected': [1655], '0.5': [1657], 'mg/ml': [1658], 'geneticin': [1659], '(Life': [1660], 'Technologies,': [1661], 'Inc.).': [1662], 'Relative': [1663], 'levels': [1664, 3644, 3679], 'compared': [1669, 4113, 4740], 'cell': [1671, 2565, 2868, 2907, 3063, 3102, 5993], 'clones': [1672, 1733, 2869, 3064, 3632], 'fluorescence': [1674, 2252, 2352, 2384, 3555, 3788, 3833, 4504, 4554, 4752], 'flow': [1675, 1744, 2353, 3556, 3661, 4485, 4589, 4769, 6191], 'cytometry,': [1676, 6192], 'Experiments': [1713, 1724], 'transiently': [1715, 4472, 4759, 4919], 'conducted': [1719, 1730, 2112], '48–72': [1720], 'h': [1721], 'transfection.': [1723], 'uniformly': [1734], 'determined': [1739, 2836, 2892, 2942, 3031, 3087, 3137, 4724], 'immunofluorescence': [1741, 1900, 3193], 'microscopy': [1742, 2232, 2253, 4753], 'cytometry.': [1745], 'integrity': [1748], 'tested': [1754], 'examining': [1756], 'mediate': [1760, 4445, 4986, 5157], 'etorphine-dependent': [1761, 2459, 4033, 4419, 4446, 4465, 4726, 5158], 'inhibition': [1762, 2460, 2492, 2509, 2524, 2628, 2735, 2800, 2825, 2850, 2884, 2900, 2915, 2935, 2995, 3020, 3045, 3079, 3095, 3110, 3130, 3313, 4102, 4192, 4264, 4420, 4727, 5159, 5314], 'adenylyl': [1763, 1793, 2462, 2526, 2630, 2737, 2886, 2902, 3081, 3097, 3315, 4423, 4729, 5161, 5947], 'cyclase': [1764, 1794, 2463, 2527, 2631, 2738, 2887, 2903, 3082, 3098, 3316, 4424, 4730, 5162], 'intact': [1766, 2906, 3101], 'Stably': [1768], 'grown': [1771, 1880, 2274], '24-well': [1773], 'dishes': [1774, 2277, 2281, 2292], 'preincubated': [1776], '15': [1778], 'mm': [1782, 2301], 'isobutylmethylxanthine,': [1783], 'then': [1785, 2043, 2184, 2198, 3732], 'ॖm': [1787, 1803, 2833, 3028, 3299, 4564], 'forskolin': [1788], 'added': [1790, 2175], 'absence': [1797, 2194, 3444, 3501, 3746], 'or': [1798, 2192, 3377, 3393, 3502, 3647, 4121, 4131, 4908, 5902], 'etorphine': [1804, 2486, 2512, 2716, 2834, 2879, 2982, 3029, 3074, 3177, 3285, 3471, 3506, 4227, 4355, 4412, 4565, 5209, 5217], 'extracted': [1811], '707': [1813], 'ethanol': [1814], 'cAMP': [1819, 2475, 2745, 2803, 2828, 2908, 2976, 2998, 3023, 3103, 3171], 'accumulation': [1820, 2476, 2804, 2829, 2909, 2977, 2999, 3024, 3104, 3172], 'quantitated': [1822, 4093], 'extracts': [1825], 'protein': [1828, 4890, 5909], 'binding': [1829, 2058], 'radioassay': [1830], 'kit': [1831], '(Diagnostic': [1832], 'Products': [1833], 'Corporation,': [1834], 'Los': [1835], 'Angeles,': [1836], 'CA),': [1837, 1927], 'immunocytochemical': [1875], 'localization': [1876, 1991], 'experiments,': [1877, 2858, 3053, 3371], 'glass': [1882], 'coverslips,': [1883], 'fixed': [1884, 2201], '47': [1886, 2203], 'formaldehyde': [1887, 2204], 'saline': [1890], '(PBS),': [1891], 'permeabilized': [1893, 2008, 2214], '0.27': [1895], 'Triton': [1896], 'X-100': [1897], '(Sigma).': [1898], 'Indirect': [1899], 'staining': [1901, 2007, 2089, 2213, 2347, 3657, 3777], 'performed': [1908, 2004, 2255, 2387, 2859, 3054], 'M1': [1910, 2069, 2171, 2310], 'anti-FLAG': [1911, 2070, 2172, 2311, 3372, 3408], 'antibody': [1912, 1922, 2012, 2027, 2071, 2173, 2209, 2220, 2312, 3200, 3341, 3373, 3387, 3409, 3416, 3441, 3491, 4096, 4216, 4235, 4248, 4284, 4766], '(3': [1913], 'ॖg/ml,': [1914, 1924, 2035, 2222], 'Kodak': [1915], 'IBI,': [1916], 'Haven,': [1918], 'CT)': [1919], '12CA5': [1921, 2011, 2026], '(2': [1923, 2013], 'BAbCO,': [1925], 'Berkeley,': [1926], 'respectively,': [1928, 3730], 'methods': [1932], 'fluorochrome-labeled': [1934], 'secondary': [1935], 'antibodies': [1936], '18von': [1973], 'Dual': [1990], 'first': [2006, 4617, 5600, 6147], 'ॖg/ml)': [2014, 2314], 'detect': [2016, 2095], 'washing': [2020], 'detecting': [2024], 'bound': [2025, 4411], 'Texas': [2029], 'Red-conjugated': [2030], 'goat': [2031, 2218], 'anti-mouse': [2032, 2057, 2219], 'IgG': [2033], '(5': [2034, 2221, 2487], 'Jackson': [2036, 2223], 'ImmunoResearch,': [2037], 'Malvern,': [2038], 'PA).': [2039], 'Stained': [2040, 2225], 'washed': [2044, 2337], 'PBS': [2046, 2298, 2339], 'incubated': [2048, 2185, 2307, 3494], 'normal': [2051], 'mouse': [2052], 'block': [2055, 3378], 'residual': [2056, 2342], 'sites,': [2059], 'detected': [2065, 2211, 3584], 'incubating': [2067], 'had': [2073, 4134], 'directly': [2075], 'conjugated': [2076], 'fluorescein': [2078], 'isothiocyanate': [2079], '(Molecular': [2080], 'Probes,': [2081], 'Eugene,': [2082], 'OR)': [2083], 'methods.': [2086], 'protocol': [2090], 'separately': [2094], 'constructs': [2102], 'co-expressed': [2103, 3713, 5039], 'Antibody': [2108], 'uptake': [2109, 3342, 3417, 3492, 4097, 4217, 4246], 'modification': [2115], 'procedure': [2118], '21von': [2154], '269:': [2163, 5434, 5588], '18448-18452Abstract': [2164, 5435], 'culture': [2178], '(4': [2180], 'ॖg/ml),': [2181], '30': [2187, 3279, 3496, 4241, 4567], 'agonist,': [2196, 3446, 3748], 'dissolved': [2205], 'PBS.': [2207], 'Endocytosed': [2208], 'coverslips': [2215], 'fluorescein-conjugated': [2217, 2309], 'ImmunoResearch).': [2224], 'specimens': [2226], 'examined': [2228, 2558, 3191, 3242, 3605, 3804, 4208, 4310, 4407, 4616, 5140], 'conventional': [2230], 'epifluorescence': [2231], 'Nikon': [2235], 'Diaphot': [2236], 'microscope': [2237, 2261], 'equipped': [2238, 2262], '60×': [2241], 'NA1.4': [2242], 'objective': [2243], 'fluorescein/Texas': [2246], 'Red': [2247], 'dichroic': [2248], 'filter': [2249], 'sets.': [2250], 'Confocal': [2251], 'Bio-Rad': [2258], 'MRC1000': [2259], 'confocal': [2260, 3742, 6181], 'Zeiss': [2265], '100×': [2266], 'NA1.3': [2267], 'objective.': [2268], 'After': [2269], 'appropriate': [2270, 3433], 'treatments': [2271], 'plastic': [2276], '37': [2279], '°C,': [2280, 2286], 'equilibrated': [2283], 'lifted': [2289], 'incubation': [2294], 'ice-cold': [2296], 'calcium-free': [2297], 'containing': [2299, 2318], 'EDTA,': [2302], 'suspended': [2304], '(10': [2313, 4228], 'isotonic': [2316], '60': [2324, 3533], 'label': [2327], 'present': [2330, 5494, 6085, 6134], 'membrane.': [2334, 3567], 'remove': [2341], 'unbound': [2343], 'antibody,': [2344], 'intensity': [2348], 'measured': [2350, 2528, 3659, 4517, 4574], 'cytometry': [2354, 3557], 'FACScan': [2357], 'instrument': [2358], '(Becton': [2359, 2391], 'Dickenson,': [2360], 'Palo': [2361], 'Alto,': [2362], 'CA).': [2363], 'Gating': [2364], 'live': [2366], 'propidium': [2369], 'iodide': [2370], 'light': [2372], 'scatter': [2373], 'data': [2375, 4525], 'analysis': [2376, 2968, 3163, 4453, 5626], 'quantitate': [2378, 3559], 'changes': [2379], 'mean': [2381, 2846, 2964, 3041, 3159], 'surface': [2382], 'values': [2385], 'CellQuest': [2389], 'software': [2390], 'Dickenson).': [2392], 'Functional': [2393], 'Epitope-tagged': [2439, 2469], 'confirmed': [2456, 3332, 3546, 3825, 4756], 'measuring': [2458], 'human': [2466], 'strongly': [2472, 3945, 5241, 5679], 'forskolin-stimulated': [2474, 2802, 2827, 2997, 3022, 4422], 'ॖm),': [2488], 'whereas': [2489, 3447, 3801, 4068], 'minimal': [2490], 'etorphine-induced': [2491, 2523, 2552, 2899, 2914, 2934, 3094, 3109, 3129, 3560, 3939, 4459, 4512, 4785, 4822, 4835, 4869, 4903, 5015, 5681, 5693, 5783, 5822, 5932], 'untransfected': [2496, 3391], '(Table': [2498, 2538, 3317, 4429, 4731, 4798], 'middle': [2500, 4885], 'column).': [2501, 2541], 'concentration': [2505, 2877, 2896, 2980, 3072, 3091, 3175, 3303], 'dependence': [2506, 2897, 3092], 'indicated': [2510, 2814, 2855, 3009, 3050, 3224, 3454, 3774, 4417], 'activates': [2513, 5225], 'high': [2518, 2543, 2698, 5213, 5233], 'potency.': [2519], 'IC50': [2521, 2912, 2932, 2957, 3107, 3127, 3152], '4.9': [2536], 'nm': [2537, 3518], 'right': [2540, 2642], 'This': [2542, 2890, 3085, 3319, 4745, 4898, 4928, 5288, 5335, 5949], 'potency': [2544, 2621, 2699, 2706], 'natively': [2561], '17Raynor': [2597], 'addition,': [2619], 'causing': [2627], '(TableI,': [2641], 'column,': [2643], 'Ref.': [2645], '13Keith': [2646], 'indicate': [2681, 3844, 4974, 5497, 5795, 5980], 'retain': [2691], 'be': [2695, 3583, 3931, 4177, 5004, 5505, 5613, 5837, 5889, 5941, 6088, 6114], 'Because': [2702], 'its': [2704, 4442], 'comparable': [2705], 'subsequent': [2720], 'comparing': [2722, 3655], 'properties': [2726], 'κ,': [2729], 'receptors.Table': [2733], 'IReceptor-mediated': [2734], 'cellsReceptor': [2742], 'constructInhibition': [2743], 'accumulationIC507nmNone': [2746], '(untransfected': [2747], '293)8.1': [2748], '±': [2749, 2754, 2759, 2765, 2771, 2777, 2783, 2789, 2795], '5.1': [2750], '(n': [2751, 2756, 2761, 2767, 2773, 2779, 2785, 2791, 2797], '=': [2752, 2757, 2762, 2768, 2774, 2780, 2786, 2792, 2798], '7)FLAG-δ57': [2753], '6.6': [2755], '6)1.8FLAG-κ62': [2758], '3.9': [2760], '6)4.9Cr.': [2763], '153': [2764], '8.6': [2766], '7)Cr.': [2769], '252': [2770], '7.3': [2772], '6)Cr.': [2775, 2781, 2787], '366': [2776], '4.7': [2778], '469': [2782], '7.5': [2784], '519': [2788], '6.8': [2790], '10)Cr.': [2793], '677': [2794], '4.1': [2796], '6)Etorphine-dependent': [2799], 'assayed': [2806, 2984, 3001, 3179], 'construct,': [2816, 3011], '舠Experimental': [2820, 3015], 'Procedures.舡': [2821, 3016], 'percentage': [2823, 2848, 3018, 3043], 'caused': [2830, 3025, 3569, 3675, 4230], 'triplicate': [2838, 2986, 3033, 3181], 'experiment.': [2841, 3036], 'Data': [2842, 3037], 'presented': [2844, 3039], '(±S.E.)': [2851, 3046], 'calculated': [2852, 3047], 'number': [2856, 3051, 3463], 'independently': [2864, 3059], 'isolated': [2865, 3060], 'construct.': [2873, 3068], 'IC50values': [2874, 3069], 'represent': [2875, 3070], '507': [2882, 3077], 'maximal': [2883, 3078], 'observed.': [2889, 3084], 'assaying': [2894, 3089], 'assay.': [2910, 3105, 4218], 'delta': [2919, 3114], '[13].': [2930, 3125], 'kappa': [2954, 3149], 'listed': [2958, 3153], 'table': [2961, 2989, 3156], 'represents': [2962, 3157], 'value': [2965, 3160], 'derived': [2966, 3161], 'five': [2969, 3164], 'separate': [2970, 3165], 'concentration-inhibition': [2971, 3166], 'response': [2972, 3167], 'assays,': [2973, 3168], 'wells.': [2987, 3182], 'Open': [2988], 'new': [2992], 'tab': [2993], 'Etorphine-dependent': [2994], 'subcellular': [3184], 'distribution': [3185], 'microscopy.': [3194, 3743], 'monoclonal': [3199, 3440, 4234], 'remained': [3201, 3610, 3809, 4142, 5130], 'untreated': [3207, 3255, 4149], '(Fig.': [3209, 3237, 3257, 3286, 3410, 3472, 3595, 3622, 3789, 3820, 4085, 4490, 5533], 'a)': [3211], 'antibody-tagged': [3228], 'endosomal': [3231, 4043], 'vesicles': [3232, 4044, 4239], 'throughout': [3234], 'cytoplasm': [3236], 'b).': [3239], 'conditions': [3246, 3609, 4078, 5144], 'also': [3248, 4796, 4943, 5496], 'c).': [3259, 3791], 'However,': [3260], 'marked': [3262, 4263], 'contrast': [3263], 'readily': [3266, 4073, 4749], 'failed': [3274, 3524, 4782, 4818], 'internalize': [3276], 'd).': [3288, 4089], 'No': [3289, 3384], 'approximately': [3304], '1000-fold': [3305], 'greater': [3306, 4910], 'required': [3309, 5691, 5858, 5958, 5966, 6115], 'cause': [3311, 4784, 5782, 5808], 'I).': [3318, 4430, 4799], 'difference': [3321], 'regulated': [3324, 4991, 5033, 5614, 5830, 5873, 5890, 5960], 'heterogeneous': [3334], 'populations': [3335, 3549], 'assay': [3343, 3421], 'developed': [3347], 'study': [3351, 5301, 5709, 6086], '(22Mostafapour': [3355], 'Receptors': [3362], 'Transduction.': [3363], '6:': [3365], '151-163PubMed': [3366], 'control': [3370], 'did': [3374, 4278], 'induce': [3376], '(not': [3382, 4153], 'shown).': [3383, 4154], 'different': [3401, 5899], '(HA)': [3403], 'recognized': [3405], 'a,HA-δ': [3412], 'bars),': [3413, 4261], 'indicating': [3414, 4262], 'internalization.': [3427, 4267, 4870, 5666], 'FLAG': [3434, 3725], 'little': [3437, 3490], 'agonist-induced': [3448, 4738, 4940], 'large': [3457], 'increase': [3460], 'antibody-positive': [3465], 'endosomes': [3466, 3819], 'a,': [3474, 3508], 'FLAG-δ': [3475], 'bars).': [3476, 3510, 4244], 'tag': [3488], 'exhibited': [3489, 4456, 4735, 4867, 4902, 5927], 'either': [3498], '(Fig.2': [3507], 'FLAG-κ': [3509], 'Etorphine': [3511, 3568], 'various': [3513], '(ranging': [3515], 'ॖm,': [3521], 'shown)': [3523], 'continuous': [3536], 'incubation.': [3537], 'Type-specific': [3538], 'further': [3545], 'clonal': [3548], 'removal': [3561], 'loss': [3572], 'membrane,': [3580], 'could': [3582], 'occurred': [3589], 'at½': [3591], '<': [3592], 'b,': [3597, 3763, 4060], 'closed': [3598], 'circles).': [3599], 'etorphine-activated': [3602], 'without': [3615], 'any': [3616, 4843], '>30': [3620], 'b,closed': [3624], 'squares).': [3625], 'Identical': [3626], 'results': [3627, 4156, 4489, 4496, 4973, 5495, 5517, 5851], 'those': [3638, 5965], 'equal': [3645], 'less': [3648], '(as': [3652], 'estimated': [3653], 'intensities': [3658], 'cytometry).': [3662], 'suggest': [3665, 4170, 5852, 5880], 'but': [3683, 4448, 4733, 4817, 4981, 5647, 5814], 'instead': [3684], 'reflect': [3685], 'intrinsic': [3686], 'sorting': [3691], 'proteins.': [3696, 5973], 'Supporting': [3697, 3936], 'hypothesis,': [3699, 3938], 'tags,': [3729], 'visualized': [3733], 'dual': [3740], 'color': [3741], '(Fig.3,': [3760], 'respectively).': [3764, 4494], 'Colocalization': [3765], 'yellow': [3776], 'merged': [3780, 3838], 'image,': [3781], 'overlapping': [3784], 'green': [3785, 3830], 'red': [3787, 3832], 'internalized,': [3800], 'translocated': [3817], '3,': [3821], 'd': [3822], 'ande),': [3823], 'separation': [3828], 'signals': [3834], 'image': [3839, 4293, 4604], '(Fig.3': [3840], 'f).': [3841], 'sensitive': [3855], 'biochemical': [3857, 5342], 'inhibitors': [3858, 5343], 'clathrin': [3860, 5345], 'function': [3861, 5346], 'possibility': [3923], 'may': [3930, 5888, 6087], 'blocks': [3956], 'pits': [3961, 4182, 5509], '23van': [3981], 'der': [3982], 'Bliek': [3983], 'Am': [3984], 'Redelmeier': [3985], 'T.E.': [3986], 'Damke': [3987, 4008], 'Tisdale': [3989], 'E.J.': [3990], 'Meyerowitz': [3991], 'E.M.': [3992], 'Schmid': [3993, 4014], 'S.L.': [3994, 4015], '553-563Crossref': [4000], '(585)': [4003], '24Baba': [4006], 'Hinshaw': [4010], 'J.E.': [4011], 'Ikeda': [4012], 'Warnock': [4016], 'Cold': [4018], 'Spring': [4019], 'Harbor': [4020], 'Symp.': [4021], 'Quant.': [4022], '60:': [4025], '235-242Crossref': [4026], '(40)': [4029], 'Little': [4032], 'redistribution': [4034], 'version': [4052], '(Fig.4,': [4057], 'compare': [4061], 'Fig.': [4063, 4580, 4718], '1,': [4064, 4717], 'b),': [4067], '4,': [4086], 'c': [4087], 'assay,': [4098], 'confirming': [4099], 'specific': [4101, 5313], '(Fig.5).': [4125], 'overexpression': [4128], 'no': [4135], 'effect': [4136, 4608, 4747, 4873, 4929], 'etorphine-treated': [4151, 4507], 'confirm': [4157], 'hypothesis': [4159, 5326], 'pits,': [4167], 'they': [4169], 'agonist.Figure': [4188], '5Quantitation': [4189], 'dynamin.Etorphine-dependent': [4200], 'constructs,': [4226, 6207], 'ॖm)': [4229], 'numerous': [4237], '(mock': [4243], 'Etorphine-induced': [4245], 'almost': [4250], 'completely': [4251, 4983], 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[4403], 'functional,': [4415], 'only': [4432, 5798], 'exception': [4433], '5,': [4436], 'impaired': [4440, 5943], 'signaling': [4447, 5945, 5994, 6130], 'included': [4450], 'it': [4455, 4829], 'very': [4457], 'pronounced': [4458], '(see': [4461], 'below).': [4462], '(using': [4475], 'vesicle': [4477], 'counting': [4478], 'assay)': [4479], '(by': [4484], 'cytometry)': [4486], 'yielded': [4487], '6,': [4491], 'andb,': [4493], 'summarized': [4498], 'Fig.7,': [4500], 'shows': [4502], 'representative': [4503, 4553], 'micrographs': [4505], 'ranks': [4510], 'quantitative': [4520, 4577], 'assays.Figure': [4521], '7Summary': [4522], 'structure': [4533, 5913], '(SFDOR)': [4537], '(SFKOR)': [4540], 'diagrammed,': [4549], 'together': [4550], 'micrograph': [4555], 'treated': [4561], 'min.': [4568], 'amount': [4570, 5930], 'assays': [4578, 4771], 'ranked': [4583], '−': [4585], '(<107': [4586], 'cytometry),': [4590], '+': [4592], '(10–307': [4593], 'internalization),': [4594], '++': [4596], '(>307': [4597], 'internalization).View': [4598], 'tail': [4614, 4698, 4852, 4967, 4978], 'diverges': [4622, 5648], 'greatly': [4623, 5649], 'truncation': [4629], 'point': [4631, 5714], 'mutations': [4632, 5715], 'influence': [4640, 5719], 'down-regulation': [4644], '(15Trapaidze': [4645, 5722], '27Cvejic': [4671, 5748], 'Trapaidze': [4673, 5750], 'Cyr': [4675, 5752], '4073-4076Abstract': [4684, 5761], '(93)': [4692, 5769], 'Replacing': [4695, 5667], 'carboxyl': [4697, 4977], 'created': [4711, 4812, 4862], '(Cr.': [4716, 4780, 4896, 4968, 5791, 5937], '7),': [4719], 'I)': [4732], 'reduced': [4737], 'inhibitory': [4746], 'apparent': [4750], 'cytometric': [4770], '(Figs.': [4772, 4924], '7).': [4775, 4927], 'Interestingly,': [4776, 5772, 5921], 'converse': [4778, 5817], 'mutation': [4779, 5813], '2)': [4781], 'receptor,': [4790, 4916, 5655, 6201], 'though': [4792, 5151, 5216], 'chimera': [4794], 'Similarly,': [4800], 'replacing': [4801, 4842, 4849, 4877], 'other': [4802, 4856, 5976], 'promote': [4820, 4834, 5014], '(Crs.': [4824], '4).': [4827], 'possible': [4832], 'sequence,': [4848], 'combination': [4854, 4963, 5007, 5860], 'largest': [4872, 5929], 'obtained': [4875], 'portion': [4886], '5).': [4897], 'extent': [4911], 'unique': [4935], 'domain.': [4938, 5920], 'Significant': [4939, 5191], 'distinct,': [4953], 'nonoverlapping': [4954], 'exchanged': [4961], '6).': [4969], 'Taken': [4970], 'together,': [4971], 'necessary': [4980], 'sufficient': [4984, 5806], 'subtype-specific': [4987], 'Additional': [4996], 'domain(s)': [4997, 5856], 'appear': [5002], 'necessary,': [5005], 'endocytosis,': [5036], 'agreement': [5063], 'previous': [5065, 5310, 5708], 'coupling': [5164], '(28Reisine': [5170], 'S.F.': [5173], 'Blake': [5174], 'Ann.': [5178], '780:': [5184], '168-175Crossref': [5185], '(52)': [5188], 'wide': [5206], 'range': [5207], 'extremely': [5212], 'comparably': [5232], 'potencies': [5234], 'observation': [5289, 5950], 'distinguishes': [5290], 'demonstrated': [5298, 6082], 'studies.': [5311], 'dominant-negative': [5321], 'supports': [5324], 'endocytosed': [5331], 'idea,': [5336], 'proposed': [5337], 'initially': [5338], 'suggests': [5406, 5951], 'utilized': [5421], '(21von': [5425], '29Goodman': [5442], 'O.J.': [5443], 'Krupnick': [5444], 'J.G.': [5445], 'Santini': [5446], 'Gurevich': [5448], 'V.V.': [5449], 'Penn': [5450], 'Gagnon': [5452], 'A.W.': [5453], 'Keen': [5454], 'J.L.': [5457], 'Nature.': [5458], '383:': [5460], '447-450Crossref': [5461], '(1140)': [5464], '30Zhang': [5467], 'Ferguson': [5469], 'Barak': [5471], 'Menard': [5473], 'Caron': [5475], 'M.G.': [5476, 5996], '18302-18305Abstract': [5482], '(398)': [5490], 'individual,': [5499], 'coated': [5508], 'activation.': [5515], 'reveal': [5518], 'additional': [5520, 5854], 'level': [5521], 'complexity': [5523], '8).': [5534], 'muscarinic': [5540], 'ligand-induced': [5549], '(19von': [5551], '31Tsuga': [5574], 'Kameyama': [5576], 'Haga': [5578], 'Kurose': [5580], 'Nagao': [5582], '32522-32527Abstract': [5589], 'constitute': [5598], 'class': [5601], 'protein-coupled': [5604, 5978], 'whose': [5606], 'dynamin-dependent': [5616], 'An': [5625], 'protein,': [5641], 'across': [5645], 'species': [5646], 'plays': [5656], 'role': [5659], 'inhibits': [5680], 'internalization,': [5682], 'all': [5696], 'examined.': [5701], 'findings': [5703], 'consistent': [5705], 'showing': [5710], 'truncations': [5712], 'cannot': [5779, 5836], 'itself': [5781], '2).': [5792], '舠loss': [5810], 'function舡': [5812, 5820], '舠gain': [5818], 'chimera.': [5827], 'Thus': [5828, 6074], 'fully': [5838, 5867], 'explained': [5839], 'single': [5842, 5908], 'contiguous': [5843], 'motif': [5845], 'protein.': [5849], 'Our': [5850], 'interaction': [5893, 5905], 'cellular': [5896], 'complex': [5912], 'comprised': [5914], 'our': [5935], '5)': [5938], 'appeared': [5939], 'cyclase.': [5948], 'structural': [5953], 'features': [5954], 'ligand-dependent': [5968, 5982], 'Studies': [5974], 'play': [5985], 'multiple,': [5986], 'roles': [5988], 'modulation': [5991], '(32Caron': [5995], 'Recent': [5999], 'Prog.': [6000], 'Horm.': [6001], '277-290Crossref': [6005], '33Pippig': [6009], 'Andexinger': [6011], 'Lohse': [6013], 'M.J.': [6014], '47:': [6018], '666-676PubMed': [6019], '34Bohm': [6022], 'S.K.': [6023], 'Khitin': [6024], 'L.M.': [6025], 'Grady': [6026, 6174], 'E.F.': [6027], 'Aponte': [6028], 'Payan': [6030], 'D.G.': [6031], '22003-22016Abstract': [6039], '(205)': [6047], '35Krueger': [6050], 'Daaka': [6052], 'Pitcher': [6054], 'J.A.': [6055], '5-8Abstract': [6063], '(311)': [6071], 'remarkable': [6076], 'great': [6090], 'importance': [6091], 'understanding': [6093], 'drugs.': [6110], 'Further': [6111], 'will': [6113], 'elucidate': [6117], 'precisely': [6118], 'how': [6119], 'influences': [6125], 'make': [6136], 'contribution': [6139], 'toward': [6140], 'goal': [6142], 'identifying,': [6144], 'time,': [6148], 'thank': [6169], 'Nigel': [6170, 6186], 'Eileen': [6173], 'valuable': 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