Publication Information

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3178, 3188, 3200, 3232, 3362, 3380, 3505, 3608, 3645, 3655, 3707, 3717, 3874, 3922, 3945, 3990, 4070, 4128, 4155, 4178, 4208, 4213, 4255, 4384, 4500, 4529, 4565, 4614, 4716, 4761, 4876, 5264, 5301, 5322, 5343, 5460, 5492, 5635, 5804, 5878, 5958, 5985, 5994, 6203], 'clathrin-mediated': [6, 242, 252, 488, 501, 714, 781, 1332, 5305, 5532, 5643, 5813], 'endocytosis.': [7, 94, 253, 340, 2289, 5236, 5644, 5814], 'Unlike': [8, 254], 'most': [9, 255, 1354, 3363, 3827], 'GTPases,': [10, 256, 860, 1032, 2292, 2495, 2584], 'has': [12, 258, 521, 545, 770, 1168, 3053, 3560, 3744, 4508, 5479, 5887], 'a': [13, 18, 68, 174, 208, 259, 264, 314, 420, 454, 494, 546, 553, 863, 1154, 1563, 1650, 1768, 1847, 1952, 1994, 2009, 2039, 2191, 2435, 2486, 2516, 2568, 2589, 2626, 2744, 2858, 2960, 2975, 3144, 3172, 3285, 3292, 3495, 3523, 3539, 3621, 3807, 4238, 4495, 4509, 4649, 4736, 4860, 4925, 5122, 5138, 5193, 5231, 5242, 5331, 5480, 5528, 5632, 5751, 5959], 'low': [14, 260, 2716, 3703], 'affinity': [15, 136, 261, 382, 549, 2542, 3124, 3153, 3684, 3704, 5263, 5491], 'nucleotide,': [17, 263], 'high': [19, 265, 2059, 4511], 'rate': [20, 129, 141, 266, 375, 387, 556, 563, 1617, 1632, 2060, 2201, 2444, 2653, 2969, 3643, 3712, 4513, 4583, 4905, 5336, 5483, 5496, 5577, 5638], 'of': [21, 46, 71, 79, 88, 96, 117, 130, 142, 149, 158, 198, 218, 226, 267, 292, 317, 325, 334, 342, 363, 376, 388, 395, 404, 444, 464, 472, 557, 564, 625, 705, 775, 830, 834, 856, 862, 953, 1021, 1031, 1042, 1064, 1096, 1153, 1198, 1322, 1355, 1474, 1515, 1541, 1565, 1575, 1581, 1602, 1604, 1618, 1626, 1633, 1849, 1990, 2029, 2061, 2063, 2126, 2128, 2182, 2193, 2196, 2202, 2224, 2253, 2300, 2320, 2367, 2445, 2481, 2493, 2567, 2575, 2578, 2654, 2659, 2685, 2705, 2718, 2756, 2768, 2906, 2915, 2959, 2970, 3141, 3154, 3162, 3180, 3206, 3228, 3322, 3357, 3364, 3413, 3467, 3469, 3527, 3547, 3583, 3592, 3632, 3649, 3668, 3685, 3696, 3705, 3713, 3814, 3828, 3837, 3854, 3867, 3884, 4051, 4083, 4152, 4231, 4274, 4323, 4326, 4346, 4514, 4556, 4569, 4578, 4584, 4601, 4609, 4702, 4722, 4780, 4851, 4863, 4900, 4906, 4924, 5021, 5080, 5103, 5112, 5124, 5129, 5140, 5144, 5172, 5177, 5187, 5235, 5337, 5367, 5474, 5484, 5497, 5514, 5578, 5599, 5613, 5639, 5715, 5737, 5766, 5791, 5807, 5895, 5962, 6001, 6016, 6018, 6027, 6145, 6148, 6151, 6177, 6180], 'GTP': [22, 47, 80, 89, 132, 219, 231, 237, 268, 293, 326, 335, 378, 465, 477, 483, 558, 565, 1023, 1044, 1052, 1091, 1254, 1368, 1437, 1441, 1482, 1529, 1535, 1542, 1558, 1596, 1634, 1836, 1842, 1850, 1958, 2064, 2203, 2225, 2254, 2274, 2309, 2322, 2354, 2387, 2395, 2446, 2450, 2560, 2655, 2689, 2819, 2865, 2878, 2971, 3126, 3152, 3179, 3201, 3212, 3233, 3251, 3325, 3350, 3530, 3564, 3625, 3636, 3669, 3682, 3708, 3719, 3750, 3834, 3943, 4008, 4057, 4153, 4209, 4242, 4256, 4333, 4515, 4585, 4717, 4726, 4732, 4762, 4808, 4854, 4877, 4901, 4907, 5037, 5056, 5087, 5092, 5145, 5217, 5265, 5274, 5296, 5315, 5348, 5368, 5456, 5485, 5579, 5640, 5792, 5816, 5866, 5883, 5950, 5990], 'hydrolysis,': [23, 269, 1559, 2388, 2656, 2692, 2881, 3567, 4049, 4516, 4727, 4763, 4908, 5040, 5088], 'and': [24, 34, 82, 104, 134, 153, 172, 215, 236, 270, 280, 328, 350, 380, 399, 418, 461, 482, 503, 552, 640, 858, 918, 951, 997, 1012, 1017, 1028, 1045, 1090, 1119, 1123, 1163, 1225, 1256, 1282, 1503, 1531, 1546, 1557, 1572, 1598, 1640, 1721, 1773, 1780, 1824, 1844, 1858, 2006, 2014, 2049, 2100, 2118, 2297, 2311, 2336, 2389, 2606, 2640, 2667, 2672, 2691, 2701, 2720, 2821, 2833, 2837, 2844, 2856, 2867, 2892, 3045, 3131, 3253, 3255, 3264, 3282, 3416, 3508, 3532, 3556, 3566, 3605, 3610, 3647, 3709, 3861, 3877, 3954, 4010, 4064, 4133, 4149, 4223, 4265, 4335, 4374, 4381, 4388, 4705, 4709, 4734, 4776, 4793, 4810, 4869, 4874, 4919, 4949, 5039, 5058, 5134, 5150, 5174, 5191, 5292, 5317, 5339, 5346, 5353, 5392, 5442, 5502, 5521, 5610, 5627, 5717, 5727, 5759, 5770, 5794, 5940, 5999, 6009, 6175, 6200, 6209], 'can': [25, 271, 656, 694, 1251, 3215, 5526], 'self-assemble,': [26, 272], 'forming': [27, 273], 'higher': [28, 274, 554, 634, 2730], 'order': [29, 275, 635, 2731], 'structures': [30, 276, 636], 'such': [31, 277, 637, 6004], 'as': [32, 278, 638, 661, 663, 697, 1115, 1522, 1612, 1736, 1786, 1846, 2149, 2190, 2208, 2220, 2279, 2743, 2924, 3100, 3291, 3426, 3652, 3654, 3872, 4167, 5046, 5066, 5121, 5137, 5152, 5219, 5266, 6005, 6157], 'rings': [33, 279, 639], 'spirals': [35, 281, 641, 685], 'that': [36, 115, 188, 230, 282, 361, 434, 476, 497, 524, 574, 708, 773, 801, 817, 846, 899, 986, 994, 1014, 1167, 1249, 1286, 1325, 1551, 1593, 2268, 2348, 2431, 2617, 2645, 2927, 2942, 2957, 2974, 3035, 3051, 3161, 3210, 3242, 3256, 3378, 3392, 3479, 3538, 3558, 3616, 3847, 3935, 3958, 4001, 4041, 4074, 4124, 4331, 4526, 4544, 4577, 4657, 4673, 4700, 4757, 4801, 4866, 5295, 5309, 5439, 5472, 5512, 5703, 5829, 5949, 5989, 6182], 'exhibit': [37, 283, 2270, 4867], 'up': [38, 284], 'to': [39, 75, 83, 110, 119, 151, 160, 173, 285, 321, 329, 356, 365, 397, 406, 419, 630, 632, 689, 924, 928, 1047, 1084, 1110, 1120, 1171, 1434, 1523, 1547, 1613, 1675, 1690, 1852, 2000, 2112, 2259, 2280, 2314, 2328, 2341, 2361, 2382, 2390, 2405, 2434, 2441, 2499, 2510, 2521, 2535, 2547, 2555, 2608, 2613, 2638, 2697, 2725, 2919, 3073, 3143, 3284, 3342, 3374, 3397, 3422, 3476, 3494, 3521, 3573, 3586, 3675, 3747, 3811, 3856, 3869, 3888, 3897, 3908, 3940, 3966, 3986, 4012, 4044, 4053, 4288, 4370, 4533, 4559, 4576, 4669, 4747, 4888, 5283, 5468, 5732, 5777, 5873, 5890, 6023, 6159, 6167, 6197], '100-fold': [40, 286, 664], 'stimulated': [41, 287, 1830, 2761, 2918, 4590, 5100], 'activity.': [43, 289, 1832, 4787, 5615], 'role(s)': [45, 291], 'binding': [48, 90, 232, 294, 336, 478, 922, 1089, 1174, 1255, 1369, 1442, 1483, 1530, 1556, 1597, 2275, 2310, 2355, 2413, 2451, 2690, 2866, 2879, 3213, 3252, 3326, 3531, 3550, 3565, 3670, 3683, 3695, 3751, 3755, 3813, 3835, 3849, 3896, 3981, 4058, 4334, 4809, 5038, 5057, 5218, 5228, 5275, 5297, 5316, 5793], 'and/or': [49, 91, 295, 337, 2276, 2356, 2565, 2630, 3486, 5786], 'hydrolysis': [50, 81, 92, 133, 143, 220, 238, 296, 327, 338, 379, 389, 466, 484, 1257, 1438, 1532, 1543, 1635, 1837, 2204, 2277, 2447, 2561, 2972, 3254, 3351, 4154, 4243, 4336, 4568, 4586, 4811, 4878, 5059, 5146, 5349, 5486, 5580, 5641, 5817, 5867, 5884, 5951, 5991], 'in': [51, 57, 93, 191, 202, 244, 297, 303, 339, 437, 448, 490, 687, 692, 710, 813, 921, 934, 945, 984, 1039, 1061, 1068, 1087, 1258, 1292, 1314, 1367, 1485, 1506, 1526, 1568, 1645, 1649, 1663, 1761, 1767, 1875, 1951, 1972, 1987, 2008, 2137, 2263, 2288, 2316, 2334, 2353, 2401, 2483, 2602, 2610, 2621, 2628, 2664, 2688, 2765, 2812, 2863, 2903, 2951, 2982, 3057, 3197, 3203, 3244, 3249, 3289, 3328, 3335, 3345, 3348, 3419, 3455, 3484, 3544, 3562, 3600, 3623, 3628, 3823, 3905, 3969, 3978, 4042, 4228, 4241, 4253, 4271, 4342, 4368, 4378, 4494, 4503, 4537, 4605, 4654, 4660, 4675, 4739, 4884, 4938, 5035, 5086, 5114, 5154, 5245, 5261, 5288, 5304, 5325, 5359, 5490, 5519, 5531, 5569, 5642, 5681, 5753, 5812, 5822, 5826, 5880, 5885, 5965, 5988, 5996, 6029, 6155, 6206], 'endocytosis': [52, 200, 243, 298, 446, 489, 502, 715, 782, 1333, 1525, 1608, 1619, 4891, 4931, 5065, 5074, 5095, 5113, 5173, 5306, 5338, 5465, 5533, 5628], 'remain': [53, 299], 'unclear': [54, 300], 'because': [55, 301, 1034, 3974, 5450], 'mutations': [56, 98, 302, 344, 1567, 1642, 1760, 2647, 2661, 2855, 3037, 3063, 3339, 3394, 3599, 3687, 4782, 5452, 5601], 'the': [58, 77, 86, 97, 128, 135, 147, 156, 165, 183, 192, 213, 223, 304, 323, 332, 343, 374, 381, 393, 402, 411, 429, 438, 459, 469, 562, 702, 824, 827, 831, 847, 852, 891, 929, 942, 949, 954, 998, 1006, 1019, 1025, 1040, 1062, 1079, 1097, 1151, 1161, 1173, 1194, 1259, 1356, 1472, 1513, 1539, 1549, 1569, 1576, 1582, 1586, 1616, 1624, 1631, 1654, 1659, 1670, 1696, 1703, 1713, 1722, 1854, 1862, 1973, 2057, 2180, 2194, 2199, 2221, 2264, 2293, 2301, 2318, 2365, 2407, 2443, 2478, 2490, 2523, 2531, 2563, 2573, 2576, 2579, 2615, 2618, 2632, 2643, 2652, 2668, 2683, 2706, 2752, 2766, 2828, 2845, 2853, 2870, 2882, 2887, 2898, 2904, 2907, 2912, 2920, 2943, 2952, 2955, 2968, 2983, 3068, 3118, 3122, 3150, 3168, 3176, 3186, 3198, 3204, 3211, 3226, 3270, 3278, 3320, 3355, 3465, 3470, 3488, 3501, 3548, 3553, 3569, 3581, 3590, 3629, 3642, 3650, 3680, 3697, 3702, 3710, 3832, 3885, 3898, 3909, 3959, 3970, 3975, 3979, 4080, 4087, 4147, 4206, 4229, 4262, 4272, 4343, 4371, 4504, 4534, 4538, 4551, 4599, 4606, 4610, 4663, 4676, 4703, 4753, 4771, 4802, 4836, 4840, 4898, 4904, 5110, 5126, 5170, 5175, 5183, 5259, 5335, 5340, 5458, 5495, 5575, 5600, 5617, 5648, 5735, 5741, 5788, 5805, 5875, 5892, 5995, 6146, 6173], 'domain': [60, 73, 306, 319, 833, 850, 894, 1067, 1100, 1197, 1290, 1320, 2267, 2303, 4536, 4613, 4756], 'so': [61, 307, 1358, 1611, 2278], 'far': [62, 308, 1359], 'studied': [63, 309, 1360, 5602], 'impair': [64, 310, 5455, 6184], 'both.': [65, 311, 1637, 4910], 'We': [66, 312, 2257, 2850, 5164, 5370, 5508, 6194], 'generated': [67, 313, 1644, 2663, 4859], 'new': [69, 315, 1566, 1591, 1769, 1953, 4496, 4861, 6178], 'series': [70, 316, 1564, 4862], 'mutants': [74, 171, 320, 417, 1321, 1357, 1592, 1606, 2142, 2847, 3585, 3839, 4883, 5444, 5516, 6015, 6181], 'probe': [76, 322, 1538], 'mechanism': [78, 324, 1540, 3571], 'further': [84, 330], 'test': [85, 331, 2281, 2371, 2614, 3676], 'role': [87, 333, 1505, 2487, 2627, 2684, 2859, 3056, 3622, 4738, 5634, 5752, 5806], 'Each': [95, 341, 2041, 2658], 'had': [99, 345, 5061], 'parallel': [100, 346], 'effects': [101, 347, 1473, 1601, 2272, 3066, 3466, 4047, 4450, 4871, 5463, 5606, 6147], 'on': [102, 348, 1481, 1607, 1861, 2273, 2818, 3067, 3175, 3324, 3399, 3516, 3689, 3841, 4007, 4048, 4060, 4092, 4451, 4853, 4872, 5064, 5157, 5182, 5199, 5252, 5464, 5607, 5708], 'assembly-stimulated': [103, 131, 216, 349, 377, 462, 1227, 2702, 2838, 2893, 3046, 3135, 3349, 3593, 3624, 3991, 4150, 4546, 5200, 5347, 5523, 5611, 5809, 6186], 'basal': [105, 214, 351, 460, 555, 1823, 2700, 2753, 2836, 2891, 3044, 3130, 3507, 3914, 4148, 4219, 4259, 4785, 5184, 5253, 5345, 5576, 5609, 5624, 5637, 5746, 6188], 'activities.': [107, 353], 'In': [108, 354, 2582, 3930, 4744, 5072, 5205, 5327, 5596, 6171], 'contrast': [109, 355, 3907], 'previous': [111, 357, 2773, 3074, 4013, 4088, 4376, 4953], 'reports,': [112, 358], 'we': [113, 359, 1560, 2326, 2825, 2940, 3033, 3673, 3805, 3845, 4075, 4122, 4542, 4697, 4764, 4886, 5329, 5620], 'find': [114, 360, 3846, 4123], 'mutation': [116, 148, 157, 362, 394, 403, 2433, 2507, 2534, 2872, 2884, 2929, 3120, 3170, 3406, 3468, 3520, 3853, 3866, 3883, 3961, 4050, 4701, 4721, 4804], 'Thr-65': [118, 364, 2496, 3036, 3052, 3142, 3265, 3887, 4052, 4723], 'Ala': [120, 161, 366, 407, 2639, 3858, 3889, 4054], '(or': [121, 367], 'Asp': [122, 152, 368, 398, 2536, 2641, 3860], 'or': [123, 369, 744, 927, 1071, 1533, 1629, 1636, 1983, 2198, 2503, 2537, 2650, 2880, 3347, 3375, 3756, 3859, 4856, 4909, 5026, 5136, 5225, 6187], 'His)': [124, 370], 'dramatically': [125, 181, 371, 427], 'lowered': [126, 145, 372, 391, 3121, 3160], 'both': [127, 212, 373, 458, 2699, 2864, 2890, 3043, 3250, 3267, 3506, 3563, 4061, 4125, 4146, 4245, 4385, 4807, 5036, 5314, 5344, 5608], 'GTP.': [138, 168, 384, 414, 1517, 2581, 3071, 4570], 'assemblystimulated': [140, 386], 'was': [144, 390, 1432, 1673, 1688, 1708, 1730, 1962, 2022, 2034, 2043, 2051, 2093, 2135, 2188, 2380, 2429, 2439, 2497, 2508, 2636, 2662, 2713, 2736, 2760, 2917, 3372, 3417, 3596, 3901, 4932, 5075, 5084, 5119, 5230, 5357], 'by': [146, 155, 392, 401, 718, 867, 1158, 1544, 1653, 1694, 2205, 2588, 3127, 3132, 3192, 3428, 3503, 3598, 3692, 3852, 3865, 3998, 4138, 4291, 4550, 4592, 4934, 5078, 5101, 5222, 5268, 5313, 5500, 5504, 5785, 5868, 5952], 'Ser-61': [150, 396, 2358, 2379, 2944, 2981, 3263, 3855, 4708], 'increased': [154, 400, 3149, 3191, 3500], 'Thr-141': [159, 405, 2620, 3480, 3559, 3868, 4710], 'without': [162, 408, 1439, 2448, 2896], 'significantly': [163, 409, 547, 1435, 2875, 2885, 3159, 4136, 4174, 4783, 5076, 5573], 'altering': [164, 410], 'Km': [166, 184, 412, 430, 1859, 2247, 2899, 3069, 3177, 3187, 3199, 3227, 3690, 3842, 3881, 3910, 3987, 4062, 4132, 4207, 4254, 4382, 4873, 5223, 5269], 'For': [169, 415, 2290, 5107], 'some': [170, 416, 1081], 'lesser': [175, 421], 'extent': [176, 422, 2181, 2922, 5111], 'WT': [178, 424, 2842], 'dynamin,': [179, 228, 425, 474, 1323, 2206, 2482, 4903], 'self-assembly': [180, 426, 803, 1224, 2728, 2934, 3293, 3323, 3346, 5318, 5520], 'altered': [182, 428], 'GTP,': [186, 432, 5493], 'suggesting': [187, 229, 433, 475, 816, 1324, 2926, 4525], 'conformational': [189, 435, 2306, 3218, 3260, 3333, 4338, 5310, 5824], 'changes': [190, 436, 2307, 3196, 3219, 3334, 4339, 5311, 5825], 'active': [193, 439, 4372, 4602], 'site': [194, 440, 1175, 4373, 4603], 'accompany': [195, 441], 'self-assembly.': [196, 442, 2748, 3222, 3237], 'Analysis': [197, 443, 1580, 6144], 'transferrin': [199, 445, 2130, 2183, 4936, 5043, 5447, 5498], 'rates': [201, 217, 447, 463, 4151, 4892, 5143, 5171, 5342, 5366, 5612, 5629], 'cells': [203, 449, 712, 1315, 1735, 2139, 2676, 4942, 5360, 5683], 'overexpressing': [204, 450, 1316, 4943, 5361], 'mutant': [205, 451, 779, 2108, 2708, 3900, 4236, 4390, 4864, 4920, 4944, 5239, 5281, 5362], 'dynamins': [206, 452, 2109, 4391, 4865, 4921, 4945, 5363], 'revealed': [207, 453, 1590], 'stronger': [209, 455, 3525], 'correlation': [210, 456, 2178, 5168, 5195, 5333, 5619], 'with': [211, 222, 457, 468, 948, 1005, 1016, 1102, 1280, 1471, 1512, 1623, 1630, 1682, 1726, 1964, 2026, 2121, 2344, 2552, 2642, 2678, 2772, 3224, 3386, 3512, 3879, 4169, 4897, 4952, 5068, 5272, 5364, 5487, 5721, 5740, 5757, 5760, 5946], 'than': [221, 467, 573, 3184, 3377, 3942, 4176], 'calculated': [224, 470, 2207, 5127, 5180, 5197, 5341], 'ratio': [225, 471, 1625, 2195, 4899, 5128], 'dynamin-GTP/free': [227, 473], 'not': [234, 480, 810, 1059, 2600, 2874, 2931, 2948, 3341, 5299, 5572, 5800, 5955], 'sufficient,': [235, 481], 'required': [240, 486, 1222, 1330, 2526, 4760, 5957, 5993], 'vivo.': [245, 491, 5326, 5881], 'Dynamin': [492, 520, 684, 2122, 3459, 3633, 4507, 5719], 'large': [495], 'synaptic': [504], 'vesicle': [505, 5963], 'recycling': [506, 5879, 6000], '(1Conner': [507], 'S.D.': [508], 'Schmid': [509, 532, 644, 787, 1234, 1266, 1299, 1340, 1376, 1414, 1792, 2163, 2798, 3018, 4438, 4984, 5377, 5538, 5553, 5585, 5690, 5835, 5922, 5971], 'S.L.': [510, 533, 645, 788, 1235, 1267, 1300, 1341, 1377, 1415, 1793, 2164, 2799, 3019, 4439, 4985, 5378, 5539, 5554, 5586, 5691, 5836, 5923, 5972], 'Nature.': [511, 646, 735, 1236, 1457, 2466, 3003, 3090, 3444, 3774, 4029, 4112, 4309, 4425, 4440, 4826, 4969, 5408, 5540, 5587, 5837], '2003;': [512, 535, 759, 5974, 6131], '422:': [513], '37-44Crossref': [514], 'PubMed': [515, 538, 597, 619, 650, 679, 739, 762, 795, 885, 972, 1141, 1215, 1240, 1274, 1306, 1348, 1384, 1403, 1424, 1461, 1753, 1800, 2085, 2171, 2233, 2470, 2789, 2806, 3007, 3028, 3094, 3316, 3448, 3738, 3778, 3799, 4033, 4116, 4313, 4363, 4406, 4429, 4444, 4641, 4691, 4830, 4973, 4994, 5015, 5387, 5412, 5433, 5544, 5561, 5591, 5672, 5698, 5841, 5860, 5913, 5935, 5977, 6054, 6085, 6123, 6139], 'Scopus': [516, 539, 598, 651, 680, 740, 763, 796, 886, 973, 1142, 1216, 1241, 1275, 1307, 1349, 1385, 1404, 1425, 1462, 1801, 2086, 2172, 2234, 2471, 2790, 2807, 3008, 3029, 3095, 3449, 3739, 3779, 3800, 4034, 4117, 4196, 4314, 4364, 4407, 4430, 4445, 4642, 4692, 4831, 4974, 4995, 5016, 5388, 5413, 5434, 5545, 5562, 5592, 5673, 5699, 5842, 5861, 5914, 5936, 5978, 6055, 6086, 6140], '(3101)': [517], 'Google': [518, 541, 600, 620, 653, 682, 742, 765, 798, 888, 975, 1144, 1218, 1243, 1277, 1309, 1351, 1387, 1406, 1427, 1464, 1754, 1803, 2088, 2174, 2236, 2473, 2792, 2809, 3010, 3031, 3097, 3317, 3451, 3741, 3781, 3802, 4036, 4119, 4198, 4316, 4366, 4409, 4432, 4447, 4644, 4694, 4833, 4976, 4997, 5018, 5390, 5415, 5436, 5547, 5564, 5594, 5675, 5701, 5844, 5863, 5916, 5938, 5980, 6057, 6088, 6104, 6124, 6142], 'Scholar).': [519, 542, 621, 654, 683, 889, 1145, 1219, 1244, 1310, 1352, 1428, 1465, 1804, 2089, 2175, 2237, 2474, 2810, 3318, 3452, 3803, 4120, 4199, 4317, 4645, 4695, 4834, 5565, 5595, 5864, 5981, 6143], 'biochemical': [522, 825, 2346], 'properties': [523, 2347, 5186, 5255], 'distinguish': [525, 2350], 'it': [526, 544, 769, 1519, 2428, 2635, 3663, 3743, 3955, 4728, 4845], 'from': [527, 567, 1706, 1867, 2065, 2211, 2489, 2674, 5279, 5711, 5734], 'typical': [528], 'GTPases': [529, 904, 3104, 3876, 6003], '(2Song': [530], 'B.D.': [531, 784, 1263, 1789, 2795], 'Biochemistry.': [534, 593, 2081, 3734], '42:': [536], '1369-1376Crossref': [537], '(102)': [540], 'Specifically,': [543], 'lower': [548, 2442, 4141, 4161, 5365, 5482], 'nucleotide': [551, 956, 1088, 1555, 2412, 2512, 2528, 2541, 3549, 3928], 'hydrolysis.': [559, 1092, 1599, 2396, 2868, 3533, 3626, 4718, 5369, 5795], 'Most': [560], 'notably,': [561], 'dissociation': [566, 2062, 3648, 3714], '104': [570], 'times': [571], 'faster': [572], 'from,': [575], 'example,': [577], 'Ras': [578, 857, 1103], '(3Binns': [579, 2067, 3720], 'D.D.': [580, 1411, 2068, 3015, 3721, 4981, 5374], 'Helms': [581, 2069, 3722], 'M.K.': [582, 2070, 3723], 'Barylko': [583, 2071, 3724], 'B.': [584, 668, 722, 1444, 2072, 2453, 2778, 2990, 3077, 3431, 3725, 3761, 4016, 4099, 4188, 4296, 4395, 4412, 4813, 4956, 5395, 5849], 'Davis': [585, 2073, 3726], 'C.T.': [586, 2074, 3727], 'Jameson': [587, 2075, 3728], 'D.M.': [588, 2076, 3729], 'Albanesi': [589, 2077, 3730], 'J.P.': [590, 2078, 3731], 'Eccleston': [591, 604, 2079, 3732], 'J.F.': [592, 605, 2080, 3733], '2000;': [594, 2082, 3735, 4638, 4688, 5558, 6101, 6115], '39:': [595, 2083, 2231, 3736], '7188-7196Crossref': [596, 2084, 3737], '(46)': [599, 2087, 3740], 'Scholar,': [601, 1388, 1407, 2793, 3011, 3782, 4410, 4433, 4630, 4977, 4998, 5416, 5548, 5845, 5917, 6058, 6089, 6105, 6125], '4Neal': [602], 'S.E.': [603], 'Hall': [606, 907, 1492, 2416, 3107, 4620], 'A.': [607, 730, 758, 875, 906, 908, 962, 1131, 1205, 1452, 1491, 1493, 2415, 2417, 2461, 2998, 3085, 3106, 3108, 3300, 3306, 3439, 3769, 4024, 4107, 4304, 4420, 4619, 4621, 4821, 4964, 5403], 'Webb': [608], 'M.R.': [609], 'J.': [610, 881, 968, 1137, 1211, 1302, 1342, 1378, 1397, 1748, 2165, 3307, 4189, 5004, 5009, 5422, 5427, 5555, 5666, 5692, 5924, 6079, 6098, 6112], 'Biol.': [611, 675, 790, 1269, 1344, 1380, 1399, 1419, 1795, 2167, 2785, 2801, 3023, 3308, 3794, 4359, 4402, 4989, 5011, 5382, 5429, 5557, 5694, 5856, 5908, 5925, 6081, 6113], 'Chem.': [612, 3309, 4191, 5926, 6114], '1988;': [613], '263:': [614], '19718-19722Abstract': [615], 'Full': [616, 3313, 5930, 5932, 6049, 6051, 6118, 6120, 6134, 6136], 'Text': [617, 3314, 5931, 5933, 6050, 6052, 6119, 6121, 6135, 6137], 'PDF': [618, 3315, 5934, 6053, 6122, 6138], 'Another': [622], 'distinguishing': [623], 'feature': [624], 'its': [628, 1069, 1504, 2373, 2432, 3420, 3492, 4045], 'ability': [629, 2546, 2554, 3421, 3582], 'selfassemble': [631], 'form': [633], '(5Hinshaw': [642, 5833], 'J.E.': [643, 4355, 5834, 5921, 6076], '1995;': [647, 5838], '374:': [648, 5839], '190-192Crossref': [649, 5840], '(665)': [652, 5843], 'Self-assembly': [655], 'stimulate': [657], 'activity': [660, 1229, 1328, 2704, 2712, 2735, 2755, 2895, 2914, 3048, 3137, 3415, 3511, 3595, 4078, 4329, 4555, 5202, 5525, 5626, 5748, 5811, 6028, 6154], 'much': [662], '(6Stowell': [665, 2775, 4392], 'M.H.B.': [666, 2776, 4393, 5847], 'Marks': [667, 2777, 4292, 4394, 5848], 'Wigge': [669, 2779, 4396, 5850], 'P.': [670, 2780, 4351, 4397, 4789, 5851], 'McMahon': [671, 733, 1455, 2464, 2781, 3001, 3088, 3442, 3772, 4027, 4110, 4307, 4398, 4423, 4824, 4967, 5406, 5852], 'H.T.': [672, 734, 1456, 2465, 2782, 3002, 3089, 3443, 3773, 4028, 4111, 4308, 4399, 4424, 4825, 4968, 5407, 5853], 'Nat.': [673, 2783, 4356, 4400, 5854], 'Cell': [674, 1343, 1379, 1398, 2166, 2784, 4401, 5010, 5428, 5556, 5693, 5855, 6080, 6099], '1999;': [676, 1237, 2786, 4193, 4403, 4441, 5541, 5588, 5857], '1:': [677, 2787, 4404, 5858], '27-32Crossref': [678, 2788, 4405, 5859], '(314)': [681, 2791, 4408, 5862], 'similar': [686, 3373], 'dimensions': [688], 'those': [690, 4289], 'formed': [691, 1157], 'vitro': [693, 5155, 5886, 5966, 6030], 'be': [695, 1172, 2362, 3330, 3343, 3482, 3574, 3996, 4742, 5320, 5775, 5819, 5944, 5956, 6165, 6192], 'detected': [696, 812], 'electron': [698], 'dense': [699], 'collars': [700, 808], 'around': [701, 1010], 'elongated': [703], 'necks': [704], 'endocytic': [706], 'intermediates': [707], 'accumulate': [709], 'mammalian': [711], 'when': [713, 2763, 4162, 4201, 4226, 4269, 4280, 4519, 5196, 5250], 'inhibited': [717, 3529, 3891, 5042, 5077, 5446], 'perturbing': [719], '(7Marks': [721, 1443, 2452, 2989, 3076, 3430, 3760, 4015, 4098, 4295, 4812, 4955, 5394], 'Stowell': [723, 1445, 2454, 2991, 3078, 3432, 3762, 4017, 4100, 4297, 4413, 4814, 4957, 5396], 'M.H.': [724, 1446, 2455, 2992, 3079, 3433, 3763, 4018, 4101, 4298, 4414, 4815, 4958, 5397], 'Vallis': [725, 1447, 2456, 2993, 3080, 3434, 3764, 4019, 4102, 4299, 4415, 4816, 4959, 5398], 'Y.': [726, 1448, 1745, 2457, 2994, 3081, 3435, 3765, 3788, 4020, 4103, 4300, 4416, 4817, 4960, 5399, 5902], 'Mills': [727, 1449, 2458, 2995, 3082, 3436, 3766, 4021, 4104, 4301, 4417, 4818, 4961, 5400], 'I.G.': [728, 1450, 2459, 2996, 3083, 3437, 3767, 4022, 4105, 4302, 4418, 4819, 4962, 5401], 'Gibson': [729, 1451, 2460, 2997, 3084, 3438, 3768, 4023, 4106, 4303, 4419, 4820, 4963, 5402], 'Hopkins': [731, 1453, 2462, 2999, 3086, 3440, 3770, 4025, 4108, 4305, 4421, 4822, 4965, 5404], 'C.R.': [732, 1454, 2463, 3000, 3087, 3441, 3771, 4026, 4109, 4306, 4422, 4823, 4966, 5405], '2001;': [736, 882, 969, 1138, 1212, 1421, 1458, 2467, 3004, 3025, 3091, 3445, 3775, 4030, 4113, 4310, 4426, 4827, 4970, 4991, 5012, 5384, 5409, 5430], '410:': [737, 1459, 2468, 3005, 3092, 3446, 3776, 4031, 4114, 4311, 4427, 4828, 4971, 5410], '231-235Crossref': [738, 1460, 2469, 3006, 3093, 3447, 3777, 4032, 4115, 4312, 4428, 4829, 4972, 5411], '(379)': [741, 1463, 2472, 3009, 3096, 3450, 3780, 4035, 4118, 4315, 4431, 4832, 4975, 5414], 'Scholar)': [743, 766, 917, 1502, 4367, 5391, 5437, 5676, 5702], 'clathrin': [745], '(8Iversen': [746], 'T.-G.': [747], 'Skretting': [748], 'G.': [749, 6074, 6129], 'Sandvig': [750], 'K.': [751, 3298, 3302, 3784, 5898, 6032], 'Proc.': [752], 'Natl.': [753], 'Acad.': [754], 'Sci.': [755, 6100], 'U.': [756], 'S.': [757, 1231, 1739, 4435, 4794, 5535, 5550, 5582, 6040], '100:': [760], '5175-5180Crossref': [761], '(66)': [764], 'function.': [767], 'Recently,': [768], 'been': [771, 811, 1169, 3745, 5888], 'shown': [772, 3822, 5511, 5889], 'overexpression': [774, 1603, 5020, 5079, 5102, 5473, 5513, 6162], 'an': [776, 979, 1048, 2096, 2132, 3054, 3665, 4250, 4266, 4745], 'assembly-defective': [777], 'blocks': [780], '(9Song': [783, 1262, 1788], 'Yarar': [785, 1264, 1790, 2796], 'D.': [786, 1265, 1791, 2797, 6109], 'Mol.': [789, 1268, 1418, 1794, 2800, 3022, 3793, 4358, 4988, 5381, 5907], 'Cell.': [791, 1270, 1420, 1796, 2802, 3024, 3795, 4990, 5383, 5909, 6045, 6130], '2004;': [792, 1271, 1797, 2803, 4360, 5669], '15:': [793, 1272, 1798, 2804], '2243-2252Crossref': [794, 1273, 1799, 2805], '(67)': [797, 1276, 1802, 2808], 'Scholar),': [799, 1278, 3032, 3098, 3117, 3742, 4037, 5019, 5939], 'confirming': [800], 'required.': [805], 'However,': [806, 1245, 1353, 1466, 2954, 3061], 'have': [809, 1561, 4698, 4799, 4858, 5509, 5604], 'unperturbed': [814], 'cells,': [815], 'this': [818, 1467, 1475, 2585, 2928, 2965, 3545, 3601, 3923, 4071, 4912, 5246, 5280, 5941, 5986], 'intermediate': [819], 'very': [821, 2058], 'short-lived.': [822], 'Despite': [823], 'differences,': [826], 'three-dimensional': [828], 'structure': [829, 1063], 'A,': [836], 'which': [837, 944, 990, 1001, 2384, 2392, 3273, 4172, 4597, 4667, 5031, 5051, 5083, 5212, 5478], 'highly': [839, 1476, 2590, 3275, 4650], 'conserved': [840, 992, 2591, 2601, 3276, 4651, 4767], 'among': [841, 902], 'family': [843, 1488, 2604, 3281], 'members,': [844], 'reveals': [845], 'core': [848], 'adopts': [851], 'common': [853], 'globular': [854], 'fold': [855], 'other': [859, 1486, 2291, 2494, 2532, 3103, 3875, 6002], 'consisting': [861], 'six-stranded': [864], 'β-sheet': [865], 'surrounded': [866], 'five': [868, 2045], 'α-helices': [869], '(10Niemann': [870, 957, 1126, 1200], 'H.H.': [871, 958, 1127, 1201], 'Knetsch': [872, 959, 1128, 1202], 'M.L.': [873, 960, 1129, 1203, 1747], 'Scherer': [874, 961, 1130, 1204], 'Manstein': [876, 963, 1132, 1206], 'D.J.': [877, 964, 1133, 1207], 'Kull': [878, 965, 1134, 1208], 'F.J.': [879, 966, 1135, 1209], 'EMBO': [880, 967, 1136, 1210, 1301], '20:': [883, 970, 1139, 1213], '5813-5821Crossref': [884, 971, 1140, 1214], '(95)': [887, 974, 1143, 1217], 'Moreover,': [890, 3388, 3871], 'contains': [895], 'four': [896], 'consensus': [897], 'motifs': [898, 2492], 'are': [900, 919, 1036, 1058, 1082, 1364, 1552, 2312, 3247, 3266, 3395, 3918, 4135, 4159, 4531, 4758, 5466, 5730, 5783, 5797, 6021, 6195], 'shared': [901], 'all': [903], '(11Wittinghofer': [905, 1490, 2414, 3105, 4618], 'GTPases.': [909, 1494, 2418, 3109, 4622], '24.': [910, 1495, 2419, 3110, 4623], 'Oxford': [911, 1496, 2420, 3111, 4624], 'University': [912, 1497, 2421, 3112, 4625], 'Press,': [913, 1498, 2422, 3113, 4626], 'New': [914, 1499, 2423, 3114, 4627], 'York2000:': [915, 1500, 2424, 3115, 4628], '244-310Google': [916, 1501, 2425, 3116, 4629], 'involved': [920, 2950, 3248, 3483, 5821], 'either': [923, 2500, 2877, 3857, 5022, 5125, 5221, 6185], 'phosphate/Mg2+': [925], 'ions': [926], 'guanine': [930, 1007], 'base.': [931, 1008], 'As': [932, 1054, 2986], 'illustrated': [933], 'Fig.': [935, 2146, 3824, 5289], '1,': [936, 1479], 'these': [937, 1056, 1605, 2286, 2646, 2660, 2750, 2823, 2938, 3062, 3239, 3337, 3365, 3393, 3535, 3584, 3686, 3838, 4324, 4647, 4781, 4882, 5451, 5728, 5780, 6019, 6169], 'include:': [938], 'G1,': [939], 'also': [940, 1252, 1365, 3407, 3619, 3902, 4729, 5241, 5453, 5798], 'called': [941], 'P-loop,': [943], 'interacts': [947, 1002, 5720], 'α-': [950], 'β-phosphates': [952], 'bound': [955, 1022, 1043, 1516, 2321, 2368, 2580, 3718, 3971], 'Scholar);': [976, 2426], 'G2,': [977], 'comprising': [978], 'invariant': [980, 4664], 'Thr': [981, 1480], 'residue': [982, 2437, 2593, 2598, 2687, 2946, 2962, 3498, 3603, 4653], '(Thr-65': [983], 'dynamin)': [985], 'coordinates': [987], 'Mg2+;': [988], 'G3,': [989], 'encodes': [991], 'residues': [993, 1057, 1550, 2262, 2333, 2862, 3243, 4527, 4564, 4604, 4751, 4769], 'bind': [995], 'Mg2+': [996, 1508, 2408, 2524, 2557], 'γ-phosphate;': [999], 'G4,': [1000], 'through': [1003, 3332], 'hydrogen-bonding': [1004], 'Residues': [1009, 4502], 'G2': [1011, 2398, 2479, 2491, 4665], 'G3': [1013], 'interact': [1015], 'recognize': [1018], 'γ-phosphate': [1020, 1514, 2319, 2577], 'constitute': [1024], 'switch': [1026, 1046, 1478, 1570, 2294, 3245, 3471, 4607], '1': [1027, 1571, 1648, 1718, 2296, 2814, 3246], '2': [1029, 1573, 2298, 2337, 3457, 3472], 'regions': [1030, 1574, 2299, 4608], 'so-called': [1033], 'they': [1035, 3257, 3994], 'often': [1037], 'disordered': [1038], 'absence': [1041], 'ordered': [1049], 'conformation': [1050, 4600], 'upon': [1051, 2308, 3220, 3236, 4332], 'binding.': [1053, 1536, 2529, 3893, 3929, 5093], 'expected,': [1055, 5047], 'resolved': [1060], 'dynA': [1065], 'unoccupied': [1070], 'GDP-bound': [1072], 'states;': [1073], 'however,': [1074, 4778, 5258, 5449], 'given': [1075, 2056], 'their': [1076, 2351, 2544, 2553, 5141, 5461, 5712], 'positioning': [1077, 2564, 2629, 3485], 'near': [1078, 2364, 2980, 4662, 5053, 5214], 'γ-phosphate,': [1080], 'likely': [1083, 5731], 'play': [1085, 2625, 3620, 5750], 'roles': [1086, 2352, 3561], 'larger': [1094], 'size': [1095], 'compared': [1101, 3385, 4168, 5067, 5271], '(∼30': [1104], 'versus': [1105], '∼20': [1106], 'kDa)': [1107], 'due': [1109], 'two': [1111, 3919, 4263], 'internal': [1112], 'insertions': [1113], 'of,': [1114], 'yet,': [1116], 'undefined': [1117], 'function': [1118, 1848, 2192, 2315, 5123, 5139, 5303, 5324, 5872, 5998], 'smaller': [1121], 'C-': [1122], 'N-terminal': [1124], 'extensions': [1125], 'Also': [1146, 3518, 5045], 'unique': [1147], 'existence': [1152], 'hydrophobic': [1155, 2436, 2517, 3497, 3540], 'groove,': [1156], 'interactions': [1159, 1291, 3618, 4000, 5729, 5756, 5782], 'between': [1160, 5169, 5334, 5623], 'N-': [1162], 'C-terminal': [1164], 'α-helical': [1165], 'extensions,': [1166], 'proposed': [1170, 2313], 'GED,': [1177, 1182, 4557, 5570], '1The': [1178], 'abbreviations': [1179], 'used': [1180, 1689, 1757], 'are:': [1181], 'effector': [1184, 1196, 5725, 5781], 'domain;': [1185], 'GTPγS,': [1186], 'guanosine': [1187], '5′-3-O-(thio)triphosphate;': [1188], 'WT,': [1189], 'wild': [1190, 1719, 2113, 2757, 3229, 3381, 4156, 4214, 4386, 4917, 5054, 5215], 'type;': [1191], 'sw,': [1192], 'switch.': [1193], 'GED': [1220, 1250], '(12Sever': [1230, 5534, 5581], 'Muhlberg': [1232, 4436, 5536, 5583], 'A.B.': [1233, 1296, 4437, 5537, 5584], '398:': [1238, 4442, 5542, 5589], '481-486Crossref': [1239, 4443, 5543, 5590], '(317)': [1242, 4446, 5546, 5593], 'recent': [1246, 5947], 'data': [1247, 2939, 3240, 3614, 3691, 4039, 5286], 'suggest': [1248, 3209, 3241, 3537, 3615, 5308], 'influence': [1253], 'unassembled': [1260, 1293, 3155, 3181, 4539, 5704], 'state': [1261, 3555, 4678], 'consistent': [1279, 2771, 3878, 5945], 'cross-linking': [1281, 3758], 'limited': [1283], 'proteolysis': [1284], 'studies': [1285, 3933, 5646, 5773], 'reveal': [1287], 'stable': [1288], 'GED-GTPase/middle': [1289], '(13Muhlberg': [1295], 'Warnock': [1297, 1338, 1374, 5688], 'D.E.': [1298, 1339, 1375, 5689, 5919], '1997;': [1303, 1750], '16:': [1304], '6676-6683Crossref': [1305], '(199)': [1308], 'Endocytosis': [1311, 4852], 'blocked': [1313], 'dominant': [1317], 'negative': [1318, 2976, 4671], '(14Damke': [1334, 1370, 5684], 'H.': [1335, 1371, 1409, 1413, 2158, 3013, 3017, 4979, 4983, 5372, 5376, 5552, 5661, 5685, 6070], 'Baba': [1336, 1372, 1416, 3020, 4986, 5379, 5686], 'T.': [1337, 1373, 1417, 1743, 3021, 3786, 4987, 5380, 5687, 5900, 5970, 6044, 6066, 6127], '1994;': [1345, 1381, 5695, 6082], '127:': [1346, 1382, 5696], '915-934Crossref': [1347, 1383, 5697], '(1046)': [1350, 1386, 5700], '(K44A,': [1361], 'S45N,': [1362], 'T65F)': [1363], 'defective': [1366, 3344, 5034, 5085, 5518, 6014], '15Herskovits': [1389], 'J.S.': [1390], 'Burgess': [1391], 'C.C.': [1392], 'Obar': [1393], 'R.A.': [1394], 'Vallee': [1395], 'R.B.': [1396], '1993;': [1400, 2168, 3310], '122:': [1401, 2169], '565-578Crossref': [1402], '(398)': [1405], '16Damke': [1408, 3012, 4978], 'Binns': [1410, 3014, 4980, 5373], 'Ueda': [1412, 3016, 4982, 5375], '12:': [1422, 3026, 4992, 5385], '2578-2589Crossref': [1423, 3027, 4993, 5386], '(150)': [1426, 3030, 4996, 5389], 'One': [1429, 4067], 'mutation,': [1430], 'T65A,': [1431], 'suggested': [1433], 'inhibit': [1436], 'impairing': [1440], 'assertion': [1468], 'inconsistent': [1470], 'conserved,': [1477], 'affinities': [1484, 3836], 'members': [1489, 2605], 'coordinating': [1507], 'direct': [1510, 4065, 4737, 5226, 5273], 'interaction': [1511], 'Therefore,': [1518, 3672, 3804], 'remains': [1520, 3572, 4847], 'uncertain': [1521], 'whether': [1524, 1615, 2372, 2477, 4890, 5779], 'vivo': [1527, 5115, 5997], 'requires': [1528, 2562], 'only': [1534, 3513, 3862, 5192], 'To': [1537, 1699, 2176, 2370, 2475, 2681, 4911], 'identify': [1548, 2260, 4748], 'critical': [1553, 2261], 'made': [1562, 3912], 'domain.': [1579], 'kinetic': [1583, 2693, 2830, 4126], 'constants': [1584, 1879, 2831, 3644], 'steady-state': [1587, 2213, 5159], 'cycle': [1589, 5790], 'differentially': [1594], 'affect': [1595, 2876, 2932, 5574], 'were': [1609, 1643, 1784, 1807, 1818, 1838, 1873, 1998, 2110, 2670, 2695, 4090, 4928, 5032], 'examined': [1610, 2852, 3464], 'determine': [1614, 2177, 2476, 4889], 'correlated': [1620], 'more': [1621, 3938, 3964, 3984, 4566, 4574, 4615, 4895, 5506], 'closely': [1622, 3985], 'dynamin-GTP/unoccupied': [1627], 'Recombinant': [1638], 'Baculoviruses': [1639], 'Adenoviruses—Point': [1641], 'human': [1646, 1716, 2665], 'pBluescript': [1651, 1707], 'vector': [1652], 'QuikChange': [1655], 'method': [1656], '(Stratagene)': [1657], 'using': [1658, 2095, 2102, 2217, 2738, 3752], 'oligonucleotides': [1660], '(Operon)': [1661], 'listed': [1662], 'Table': [1664, 1876], 'I.': [1665, 5968], 'BamHI-KpnI': [1667], 'fragment': [1668, 1705], 'containing': [1669, 1712], 'entire': [1671, 3279], 'gene': [1672, 1714], 'transferred': [1674], 'pVL1393': [1676], 'vector.': [1677], 'resulting': [1679, 1723], 'plasmid': [1680, 1724], 'together': [1681, 1725], 'linearized': [1683], 'baculovirus': [1684], 'DNA': [1685, 1729], '(BaculoGold,': [1686], 'Pharmingen)': [1687], 'generate': [1691, 1700], 'recombinant': [1692, 1701, 2679, 4914], 'baculoviruses': [1693], 'following': [1695], "manufacturer's": [1697], 'instructions.': [1698], 'adenoviruses,': [1702], 'NdeI-NheI': [1704], 'subcloned': [1709], 'into': [1710, 1733, 2131, 2729], 'pADTetT3T7': [1711], 'type,': [1720], 'ψ5': [1727], 'adenovirus': [1728], 'then': [1731], 'transfected': [1732], 'HEK293-cre4': [1734], 'described': [1737, 1787, 2150], '(17Hardy': [1738], 'Kitamura': [1740], 'M.': [1741, 3296, 4184, 4791, 6036, 6068, 6072, 6095], 'Harris-Stansil': [1742], 'Dai': [1744], 'Phipps': [1746], 'Virol.': [1749], '71:': [1751], '1842-1849Crossref': [1752], 'Scholar).Table': [1755, 4448], 'IOligonucleotides': [1756], 'point': [1759], 'domainMutationSequenceS61A-f5′-CTTCTTGCCTCGAGGAGCTGGCATTGTCACC-3′S61A-r5′-GGTGACAATGCCAGCTCCTCGAGGCAAGAAG-3′S61D-f5′-CTTCTTGCCTCGAGGAGATGGCATTGTCACCCGAC-3′S61D-r5′-GTCGGGTGACAATGCCATCTCCTCGAGGCAAGAAG-3′T65A-f5′-GGATCTGGCATTGTCGCACGACGTCCCCTGGTC-3′T65A-r5′-GACCAGGGGACGTCGTGCGACAATGCCAGATCC-3′T65D-f5′-GGATCTGGCATTGTCGACCGACGTCCCCTGGTC-3′T65D-r5′-GACCAGGGGACGTCGGTCGACAATGCCAGATCC-3′T65H-f5′-GGATCTGGCATTGTCCACCGACGTCCCCTGGTC-3′T65H-r5′-GACCAGGGGACGTCGGTGGACAATGCCAGATCC-3′T141A-f5′-CCTGCCCGGAATGGCAAAGGTCCCGGTGG-3′T141A-r5′-CCACCGGGACCTTTGCCATTCCGGGCAGG-3′T141D-f5′-CCTGCCCGGAATGGACAAGGTCCCGGTGG-3′T141D-r5′-CCACCGGGACCTTGTCCATTCCGGGCAGG-3′': [1764], 'Open': [1765, 1949, 4492], 'table': [1766, 1950, 4493], 'tab': [1770, 1954, 4497], 'Proteins,': [1771], 'GTPase,': [1772, 1779], 'Velocity': [1774], 'Sedimentation': [1775], 'Assays—Protein': [1776], 'purification,': [1777], 'velocity': [1781, 3389, 3577], 'sedimentation': [1782, 3390, 3578], 'assays': [1783, 5276], 'performed': [1785, 2696, 4094], 'All': [1805], 'incubations': [1806], 'at': [1808, 1840, 1980, 1984, 2038, 2185, 2572, 2715, 2721, 2964, 3552, 4079, 4095, 4140, 4164, 4203, 4244, 4261, 4282, 4517, 4521, 5116, 5248, 5647], '37': [1809, 1981, 4084, 4170], '°C': [1810, 1982, 4166], 'unless': [1811], 'otherwise': [1812], 'noted.': [1813], 'Two': [1814], 'different': [1815, 2345], 'concentrations': [1817, 1843, 2717, 2724], 'used,': [1819], '1.0': [1820], 'μm': [1821, 1826, 1966, 2219], '0.1': [1825], 'lipid': [1828, 2741, 2769, 2908, 3207, 3358, 3400, 4232, 4275], 'tubule': [1829, 2909], 'Initial': [1833], 'velocities': [1834], 'measured': [1839, 2714, 2764, 4202, 4217, 4227, 4257, 4270, 4281, 4520], 'varying': [1841], 'plotted': [1845, 2189, 5120], 'concentration': [1851, 2223], 'obtain': [1853], 'values': [1855, 1866, 3988, 4063, 4383, 5270], 'kcat': [1857, 2888, 3502, 4380, 4875], 'based': [1860, 3688, 3840, 4059, 4091, 5156, 5181, 5198, 5251], 'Michaelis-Menten': [1863, 2212, 2829, 3638, 5158], 'equation.': [1864], 'repeated': [1868], 'measurements': [1869, 3911, 4093, 5224], '(n': [1870, 2143], '=': [1871, 2144, 2248, 3658, 3947], '3∼5)': [1872], 'summarized': [1874], 'II.Table': [1877], 'IIKinetic': [1878], 'activityDynaminBasalLipid': [1883], 'tubuleKmkcatKmkcatμmmin-1μmmin-1WT102': [1884], '±': [1885, 1887, 1889, 1891, 1893, 1895, 1897, 1899, 1901, 1903, 1905, 1907, 1909, 1911, 1913, 1915, 1917, 1919, 1921, 1923, 1925, 1927, 1929, 1931, 1933, 1935, 1937, 1939, 1941, 1943, 1945, 1947, 4458, 4460, 4462, 4464, 4466, 4468, 4470, 4472, 4474, 4476, 4478, 4480, 4482, 4484, 4486, 4488], '352.60': [1886, 4467], '0.9837': [1888], '18105': [1890, 4483], '47S61A67': [1892], '101.94': [1894], '0.2441': [1896], '2286': [1898], '13S61D68': [1900], '110.43': [1902], '0.0256': [1904], '2226.3': [1906], '1.5T65A880': [1908], '3300.075': [1910, 4471], '0.0272115': [1912], '14131.22': [1914, 4487], '0.24T65D41': [1916], '150.016': [1918], '0.002513': [1920], '380.97': [1922], '0.20T65H149': [1924], '210.018': [1926], '0.002988': [1928], '2700.95': [1930], '0.06T141A174': [1932], '966.69': [1934], '0.7956': [1936], '20185': [1938], '55T141D763': [1940], '1200.15': [1942], '0.031940': [1944], '12001.50': [1946], '0.98': [1948], 'Filter': [1955], 'Assay': [1956], 'Binding—Dynamin': [1959], '(1.0': [1960], 'μm)': [1961], 'incubated': [1963], '100': [1965, 2218], 'GTPγ35S': [1967, 3815, 3848, 3892, 3895], '(270': [1968], 'μCi/ml,': [1969], 'Amersham': [1970, 2097], 'Biosciences)': [1971], 'assay': [1975, 3982, 4221], 'buffer': [1976], '20': [1978], 'min': [1979, 2187, 5118], 'room': [1985, 4096], 'temperature': [1986, 4082, 4097, 4321], '6-well': [1988], 'arrays': [1989], 'PCR': [1991], 'tubes.': [1992], 'Using': [1993], 'multichannel': [1995], 'pipette,': [1996], 'samples': [1997, 2037], 'applied': [1999], 'nitrocellulose': [2001], '(0.45': [2002], 'μm,': [2003], 'BA85,': [2004], 'Schleicher': [2005], 'Schuell)': [2007], 'filter': [2010, 2021, 2092, 3754, 3980, 5227], 'dot-bolt': [2011], 'apparatus': [2012], '(Schleicher': [2013], 'Schuell,': [2015], 'minifold': [2016], 'I)': [2017], 'under': [2018, 3913, 4218, 4258, 4922], 'vacuum.': [2019], 'rapidly': [2023], 'washed': [2024], 'once': [2025], '250': [2027], 'μl': [2028], 'cold': [2030], 'buffer.': [2031], 'procedure': [2033], 'repeated,': [2035], 'six': [2036], 'time.': [2040], 'sample': [2042], 'assayed': [2044, 4163], 'times.': [2046], 'Rapid': [2047], 'filtration': [2048, 3809], 'washing': [2050], 'necessary': [2052], 'reproducible': [2054], 'results': [2055, 3536, 3821, 3976, 4954, 5278], 'dried': [2091], 'imaged': [2094], 'Biosciences': [2098], 'PhosphorImager': [2099], 'quantified': [2101], 'ImageQuant': [2103], 'Software.': [2104], 'Values': [2105], 'individual': [2107, 2707, 2846], 'normalized': [2111], 'type': [2114, 2758, 3230, 3382, 4157, 4215, 4387, 4918, 5055, 5216], 'dynamin.': [2115], 'Transferrin': [2116, 5355], 'Internalization': [2117], 'Its': [2119], 'Correlation': [2120], 'Activity—The': [2124], 'kinetics': [2125, 2214, 5160], 'internalization': [2127, 2184, 4937, 5356, 5499], 'biotinylated': [2129], 'avidin-inaccessible': [2133], 'compartment': [2134], 'determined': [2136, 2737, 2827, 5153, 5220], 'tTA-HeLa': [2138, 4941], 'expressing': [2140, 4916], '6,': [2145], '2),': [2147, 3589], 'exactly': [2148], '(18van': [2151], 'der': [2152, 5002, 5420], 'Bliek': [2153], 'A.M.': [2154], 'Redelmeier': [2155], 'T.E.': [2156, 6097], 'Damke': [2157, 5551], 'Tisdale': [2159], 'E.J.': [2160], 'Meyerowitz': [2161], 'E.M.': [2162, 4632, 4682], '553-563Crossref': [2170], '(591)': [2173], 'coefficients,': [2179], '10': [2186, 5117], 'dynamin-GTP/dynamin': [2197, 5130], 'relative': [2200, 3681, 3833, 5142], 'indicated': [2209], 'below': [2210], '(Equation': [2215], '1)': [2216, 2239], 'intracellular': [2222], '(19Otero': [2226], 'A.D.': [2227], 'Biochem.': [2228, 4637, 4687], 'Pharmacol.': [2229], '1990;': [2230], '1399-1404Crossref': [2232], '(104)': [2235], 'Dyn+GTP⇄k−1k1Dyn-GTP→kcatDyn+GDP+Pi(Eq.': [2238], 'k1[Dyn][GTP]=(k−1+kcat)[Dyn-GTP](Eq.': [2240], '2)': [2241, 3425], '[GTP](k−1+kcat)k1=[Dyn-GTP][Dyn](Eq.': [2242], '3)': [2243], '[Dyn-GTP][Dyn]=[GTP]Km(Eq.': [2244], '4)': [2245], 'where': [2246], '(k–1': [2249, 3659], '+': [2250, 3660], 'kcat)k1.': [2251], 'Rate': [2252], 'hydrolysis=kcatKm[Dyn][GTP](Eq.': [2255], '5)': [2256], 'sought': [2258, 3674, 4887], 'would': [2269, 2385, 2550, 4893, 5943, 6191], 'differential': [2271, 2283, 3065, 4252, 4268, 4868], 'requirements': [2284], 'activities': [2287, 2840, 6190], '(sw)': [2295], 'undergo': [2304, 3216, 3258], 'major': [2305], 'sensing': [2317], '(Fig.': [2323, 3402, 3424, 3588, 4879, 4946, 5131, 5147, 5189, 5203, 5208, 5256, 5350], '1).': [2324], 'Thus,': [2325, 2612, 3844, 4145, 4541, 4835, 5616, 5745], 'chose': [2327], 'mutate': [2329], 'three': [2330, 4766], 'amino': [2331, 2342], 'acid': [2332], 'sw1': [2335, 2402, 2854, 2861, 3338, 3886, 4704, 4772], '(Ser-61,': [2338], 'Thr-65,': [2339], 'Thr-141)': [2340], 'acids': [2343], 'could': [2349, 2623, 3481], 'catalysis.': [2357, 2953], 'postulated': [2360], 'located': [2363, 3268, 4659, 5568], 'β-phosphate': [2366], 'GDP.': [2369], 'hydroxyl': [2374, 2945], 'group': [2375], 'might': [2376, 2393, 2539, 2648], 'facilitate': [2377], 'catalysis,': [2378, 4712], 'mutated': [2381, 2498, 2637, 4765], 'Ala,': [2383, 2501, 2515], 'disrupt': [2386], 'Asp,': [2391, 2502, 3147, 3522], 'enhance': [2394], 'motif': [2399, 2480, 3294], '(Thr-65)': [2400], 'believed': [2404], 'coordinate': [2406, 2522, 2556], 'ion': [2409, 2525], 'thus,': [2427, 3662, 4735], 'surprising': [2430], '(Ala)': [2438, 3499], 'reported': [2440, 2988, 3427, 4046, 4290, 4379], 'affecting': [2449, 2897], 'fact,': [2484, 3931], 'plays': [2485], 'distinct': [2488], 'His.': [2504], 'T65A': [2506, 3119, 3405, 4235, 4389, 5443], 'hypothesized': [2509], 'prevent': [2511, 2726], 'binding,': [2513, 4733, 5457], 'since': [2514], 'residue,': [2518, 3146, 3473], 'unable': [2520], 'On': [2530], 'hand,': [2533], 'His': [2538], 'increase': [2540, 2651], 'if': [2543, 4844, 5097], 'greater': [2545, 4175], 'pull': [2548], 'protons': [2549], 'correlate': [2551, 4894], 'ion.': [2558], 'Finally,': [2559, 5094], 'activation': [2566], 'nucleophilic': [2569, 3489], 'water': [2570, 2633, 3490], 'molecule': [2571], 'backside': [2574], 'Ras-like': [2583], 'accomplished': [2587], 'glutamine': [2592, 2597], 'within': [2594, 3269, 4752, 4770, 4839], 'G3.': [2595], 'This': [2596, 4571], 'corresponds': [2607, 3283], 'Met-140': [2609], 'dynamin-1.': [2611], 'hypothesis': [2616, 3478], 'neighboring': [2619], 'sw2': [2622, 3602, 3617, 4706], 'instead': [2624], 'activating': [2631, 3487, 4553, 4595], 'molecule,': [2634, 3491], 'expectation': [2644], 'reduce': [2649], 'respectively.': [2657], 'dynamin-1,': [2666], 'proteins': [2669, 5762, 6020], 'expressed': [2671], 'purified': [2673], 'insect': [2675], 'infected': [2677, 4940], 'baculoviruses.': [2680], 'assess': [2682, 5778], 'each': [2686, 5598, 6017], 'analyses': [2694], 'measure': [2698, 3667, 3749, 3812, 4076], 'dynamins.': [2709], 'Basal': [2710, 3460], 'physiological': [2722], 'salt': [2723], 'structures.': [2732], 'Assembly-stimulated': [2733, 5815], 'phosphatidylinositol': [2739], '4,5-diphosphate-containing': [2740], 'nanotubules': [2742, 3401], 'template': [2745], 'Under': [2749], 'conditions,': [2751], '40–50-fold': [2762], 'presence': [2767, 2905, 3205, 4230, 4273], 'nanotubules,': [2770], 'reports': [2774, 4014], '9Song': [2794], 'Mutations': [2811, 3627], 'Switch': [2813, 3456], 'Exhibit': [2815], 'Differential': [2816], 'Effects': [2817, 4006], 'Binding': [2820, 4009, 4855], 'Hydrolysis—Using': [2822], 'assays,': [2824, 5229], 'next': [2826, 3463], '(kcat': [2832], 'Km)': [2834], '(Table': [2848, 2900, 3059, 3138, 4143, 4277], 'II).': [2849, 2901, 3060, 3139], 'first': [2851], 'confirmed': [2857], 'Although': [2869, 3319, 3576, 4696], 'S61A': [2871], 'did': [2873, 5571], 'S61D': [2883], 'reduced': [2886, 3042, 3597, 3864, 4212, 4225, 5358], 'Importantly,': [2902], 'assembly': [2910, 5716], 'templates,': [2911], 'dyn1-S61D': [2916, 5081, 5207, 5475], 'same': [2921], '(∼50-fold)': [2923], 'dyn1-WT,': [2925], 'does': [2930], '(see': [2935, 3817, 5161], 'below).': [2936], 'From': [2937], 'conclude': [2941], 'directly': [2949, 3693, 3816, 4896, 5820], 'fact': [2956], 'substitution': [2958], 'carboxylate': [2961, 3145], '(Asp)': [2963], 'position': [2966, 4561], 'lowers': [2967], 'suggests': [2973, 4330], 'charge': [2977], 'may': [2978, 3327, 3995, 4340, 5319, 5630, 5749, 5818, 5871, 5954], 'develop': [2979, 4674], 'transition': [2984, 3554, 4677], 'state.': [2985, 4540], 'previously': [2987, 3287, 5510], 'found': [3034], '(T65A,': [3038], 'T65D,': [3039, 3370], 'T65H)': [3040], 'greatly': [3041], '(36–100-fold),': [3049], 'demonstrating': [3050], 'important': [3055, 5321], 'catalysis': [3058, 3656, 4530, 4617, 4680, 4740], 'exhibited': [3064, 5052, 5090, 5213], 'Contrary': [3072, 3475], 'observations': [3075, 5680, 5948], 'but': [3099, 3158, 5089, 5307], 'predicted': [3101, 3873], 'apparent': [3123, 3151, 5167, 5262], '8-fold': [3128], '∼50-fold': [3133, 4267], 'Mutation': [3140, 3454], 'slightly': [3148, 3863, 5099], '(2-fold)': [3157], 'assembled': [3163, 3189, 3509, 5827, 5869], '(14-fold).': [3165], 'Similarly,': [3166, 4200, 4719], 'although': [3167, 3568, 4720, 6012], 'T65H': [3169], 'showed': [3171, 3408], 'minimal': [3173], 'effect': [3174, 3321, 5063], '(less': [3183], '2-fold),': [3185], '27-fold.': [3193], 'dramatic': [3195], 'observed': [3202, 3379, 4177, 5165, 5330], 'tubules': [3208, 4276], 'pocket': [3214, 3551], 'significant': [3217, 3409, 4337, 5232, 5243], 'Consistent': [3223, 4951], 'this,': [3225], 'dynamin-1': [3231], 'decreases': [3234, 4056], '>2-fold': [3235], 'Together,': [3238, 3534], 'assembly-dependent': [3259, 3411], 'changes.': [3261], 'Interestingly,': [3262], 'sequence': [3271], '57LPRGSGIVTR66,': [3272], 'across': [3277], 'region': [3286, 3546], 'identified': [3288], 'Mx1': [3290], '(20Nakayama': [3295], 'Yazaki': [3297], 'Kusano': [3299], 'Nagata': [3301], 'Hanai': [3303], 'N.': [3304, 3792, 5653, 5906], 'Ishihama': [3305], '268:': [3311], '15033-15038Abstract': [3312], 'part': [3329], 'mediated': [3331, 4549], 'sw1,': [3336, 4661], 'appear': [3340], 'per': [3352], 'se.': [3353], 'Indeed,': [3354, 4121, 4279, 5882], 'degree': [3356, 3591, 5176], 'tubule-dependent': [3359], 'stimulation': [3361, 3412, 3607], 'mutants,': [3366], 'including': [3367], 'S61A,': [3368], 'S61D,': [3369], 'T65H,': [3371], 'better': [3376, 4560], '(44∼61-fold': [3384], '40-fold).': [3387], 'demonstrated': [3391], 'competent': [3396], 'self-assemble': [3398, 3423, 3587], '2).': [3403], '(∼16-fold)': [3410], 'unimpaired': [3418], 'others': [3429, 5393], 'A': [3453, 4498, 5133, 5291], 'Increases': [3458], 'Activity—We': [3462], 'Thr-141.': [3474], 'our': [3477, 3677, 3829, 3880, 4038, 4285, 5678], 'change': [3493, 5489], 'small': [3496, 3514], '2-fold': [3504], 'affects': [3515, 3927], 'Km.': [3517], 'unexpectedly,': [3519], 'potentially': [3524], 'activator': [3526], 'water,': [3528], 'environment': [3541], 'preferred': [3543], 'indicate': [3557, 3934], 'exact': [3570], 'established.': [3575], 'analysis': [3579, 6176], 'established': [3580, 4699, 4800], '(10-': [3604], '27-fold': [3606], 'T141D': [3609], 'T141A,': [3611], 'respectively).': [3612], 'These': [3613, 5566], 'Domain': [3631], 'Differentially': [3634], 'Affect': [3635], 'Binding—The': [3637], 'constant,': [3639], 'Km,': [3640], 'reflects': [3641], 'association': [3646, 5739], 'substrate': [3651], 'well': [3653], '(Km': [3657], 'kcat)/k1);': [3661], 'indirect': [3666], 'affinity.': [3671], 'predictions': [3678, 3830], 'regarding': [3679, 3831], 'measuring': [3694, 4935], 'nonhydrolyzable': [3698], 'analogue,': [3699], 'GTPγ35S.': [3700], 'Given': [3701], 'rapid': [3711, 3808, 5893], '(2': [3715], 's–1)': [3716], 'difficult': [3746, 5282, 5467], 'accurately': [3748], 'conventional': [3753], 'UV': [3757], 'protocols': [3759], '21Maeda': [3783], 'Nakata': [3785, 5899], 'Noda': [3787, 5901], 'Sato-Yoshitake': [3789, 5903], 'R.': [3790, 4182, 5904, 6042, 6091], 'Hirokawa': [3791, 5905], '1992;': [3796, 5910], '3:': [3797, 5911], '1181-1194Crossref': [3798, 5912], '(92)': [3801, 5915], 'developed': [3806], 'protocol': [3810], '"Experimental': [3818, 5162], 'Procedures").': [3819, 5163], '3': [3825], 'confirm': [3826, 5677], 'measurements.': [3843, 4066], 'unaffected': [3851], 'Ala.': [3870], 'data,': [3882], 'potently': [3890, 3903, 5041], 'Surprisingly,': [3894], 'T65D': [3899, 3960], 'inhibited,': [3904], 'sharp': [3906], 'conditions.': [3916], 'There': [3917, 5796, 5982], 'possible': [3920, 3957, 4068], 'explanations': [3921], 'discrepancy.': [3924], 'First,': [3925], 'thio-substitution': [3926], 'inhibition': [3932, 6150], 'GTPγS': [3936, 3946], 'binds': [3937], 'weakly': [3939], '(Ki': [3944], '340': [3948], 'μm),': [3949], '2M.': [3950], 'Leonard,': [3951, 4792], 'unpublished': [3952, 4796], 'data.': [3953, 4797], 'even': [3963], 'sensitive': [3965], 'structural': [3967], 'differences': [3968], 'nucleotide.': [3972], 'Second,': [3973], 'obtained': [3977, 3989], 'correspond': [3983, 4287], 'activity,': [3993, 4131, 4548], 'influenced': [3997], 'dynamin-dynamin': [3999], 'occur': [4002, 4341, 5733], 'during': [4003, 4679, 5763], 'filtration.': [4004], 'Temperature-dependent': [4005], 'Hydrolysis—Contrary': [4011], 'establish': [4040], 'addition': [4043, 4369], 'substantially': [4055], 'explanation': [4069], 'discrepancy': [4072], 'physiologic': [4081], '°C,': [4085, 4171, 4205, 4284], 'whereas': [4086], 'findings': [4089, 4286], 'parameters': [4127, 4325], 'kcat,': [4134], 'affected': [4137], 'incubation': [4139], 'temperatures': [4142, 4264], 'III).': [4144, 4278], '∼10-fold': [4160], '22': [4165, 4204, 4283], 'many': [4179], 'enzymes': [4180], '(22Wolfenden': [4181], 'Snider': [4183], 'Ridgway': [4185], 'C.': [4186, 6062], 'Miller': [4187], 'Am.': [4190], 'Soc.': [4192], '121:': [4194], '7419-7420Crossref': [4195], '(110)': [4197, 5017, 5435], '∼30-fold': [4211], 'conditions': [4222, 4260], '∼6-fold': [4224], 'tubules.': [4233], 'shows': [4237], 'pronounced': [4239], 'defect': [4240], 'temperatures.': [4246], 'Strikingly,': [4247], 'there': [4248], '∼9-fold': [4251], 'et': [4293], 'al.': [4294], 'relatively': [4319, 4510], 'strong': [4320, 5332], 'dependence': [4322], 'non-reacting': [4344], 'parts': [4345], '(23Chen': [4348], 'Y.J.': [4349], 'Zhang': [4350], 'Egelman': [4352], 'E.H.': [4353], 'Hinshaw': [4354, 5920], 'Struct.': [4357], '11:': [4361], '574-575Crossref': [4362], '(128)': [4365], 'explains': [4375], 'discrepancies': [4377], '7Marks': [4411], '12Sever': [4434], 'IIITemperature': [4449], 'activityLTaLipid': [4454], 'tubule.TWT': [4455], 'dynaminT65A': [4456], 'dynaminKmkcatKmkcat°Cμmmin-1μmmin-1-223.4': [4457], '1.70.19': [4459], '0.0397': [4461], '280.017': [4463], '0.00237102': [4465], '0.98880': [4469], '0.027+225.3': [4473], '2.57.6': [4475], '0.244': [4477], '8.20.062': [4479], '0.0043737': [4481], '472115': [4485], '0.24a': [4489], 'Lipid': [4490], 'tubule.': [4491], 'Search': [4499], 'Catalytic': [4501], 'Domain—': [4506], 'intrinsic': [4512, 4532, 4562, 4582], 'least': [4518, 5249], 'physiologically': [4522], 'relevant': [4523], 'temperatures,': [4524], 'propose': [4543], 'protein': [4554, 6207], 'functions': [4558, 4668], 'catalytic': [4563, 4750, 4837], 'efficient': [4567], 'situation': [4572], 'akin': [4575], 'Gα': [4579, 4611, 4655], 'subunits,': [4580], 'whose': [4581], '(1–2': [4587], 'min–1)': [4588], '∼50–100-fold': [4591], 'RGS-type': [4593], 'proteins,': [4596], 'alter': [4598, 4711], 'effective': [4616], '24Ross': [4631], 'Wilkie': [4633, 4683], 'T.M.': [4634, 4684], 'Annu.': [4635, 4685], 'Rev.': [4636, 4686], '69:': [4639, 4689], '795-827Crossref': [4640, 4690], '(937)': [4643, 4693], 'Among': [4646], 'arginine': [4652], 'subunits': [4656], 'Thr,': [4666], 'neutralize': [4670], 'charges': [4672], '(24Ross': [4681], 'residues,': [4707], 'neither': [4713, 4779], 'severely': [4724, 4730, 5033, 5454], 'impairs': [4725, 4806], 'compromises': [4731], 'cannot': [4741], 'determined.': [4743], 'attempt': [4746], 'specifically': [4759, 5517], 'Arg': [4768, 4838], 'region,': [4773], 'Arg-54,': [4774], 'Arg-59,': [4775], 'Arg-67;': [4777], 'perturbed': [4784], '3S.': [4788], 'Sholly,': [4790], 'Schmid,': [4795], 'Others': [4798], 'R66A': [4803], 'equally': [4805], 'domain,': [4843], 'exists,': [4846], 'elusive.': [4848], 'Dependence': [4850], 'Hydrolysis—We': [4857], 'graded': [4870], '4A).': [4880], 'With': [4881], 'hand': [4885], 'bound:unoccupied': [4902], 'end,': [4913], 'adenoviruses': [4915], 'control': [4923], 'tetracycline-regulatable': [4926], 'promoter': [4927], 'generated.': [4929], 'Clathrin-mediated': [4930], 'followed': [4933], 'adenovirally': [4939], '4,': [4947], 'B': [4948, 5149, 5352], 'C).': [4950], '25Hill': [4999, 5417], 'E.': [5000, 5008, 5418, 5426, 5651, 5655], 'van': [5001, 5419], 'Kaay': [5003, 5421], 'Downes': [5005, 5423], 'C.P.': [5006, 5424], 'Smythe': [5007, 5425], '152:': [5013, 5431], '309-324Crossref': [5014, 5432], 'dyn1-T65A': [5023], '(open': [5024, 5070], 'squares)': [5025], 'dyn1-T65D': [5027, 5238], '(black': [5028, 5049, 5105, 5476], 'inverted': [5029], 'triangles),': [5030], 'internalization.': [5044], 'dyn1-S61A': [5048], 'circles),': [5050], 'activities,': [5060], 'no': [5062, 5166], 'dyn1-WT': [5069], 'circles).': [5071], 'contrast,': [5073, 5328, 5505, 5597], '(diamonds),': [5082], 'normal': [5091], 'was,': [5096], 'anything,': [5098], 'dyn1-T141A': [5104], 'triangles).': [5106], 'quantitative': [5108], 'analysis,': [5109, 5247], '5,': [5132, 5148, 5209, 5290, 5351], 'C)': [5135], 'D),': [5151], 'dynamin-GTP': [5178], 'loading,': [5179], '5A)': [5190], 'weak': [5194], '5C).': [5204], 'particular,': [5206], 'black': [5210], 'diamonds),': [5211, 5477], 'dominant-negative': [5233], 'inhibitor': [5234], 'outlier': [5244], '5A);': [5257], 'disparity': [5260], 'assessed': [5267], 'renders': [5277], 'interpret.': [5284, 5469], 'Nonetheless,': [5285], 'represented': [5287], 'C,': [5293], 'argue': [5294], 'sufficient': [5300], 'induced': [5312], 'D).': [5354], '(16Damke': [5371], 'report': [5438], 'GTPase-defective': [5440], 'T65F': [5441], 'strongly': [5445], 'internalization;': [5448], 'reasons': [5459], 'inhibitory': [5462], 'Our': [5470], 'observation': [5471], '4–5-fold': [5481], 'little': [5488], 'reduces': [5494], '∼60%': [5501], 'is,': [5503], 'informative.': [5507, 6193], 'thereby': [5522], 'accelerate': [5527], 'rate-limiting': [5529], 'step': [5530], '26Sever': [5549], '150:': [5559], '1137-1148Crossref': [5560], '(196)': [5563], 'mutations,': [5567], 'here': [5603, 5622], 'equal': [5605], 'tight': [5618], 'see': [5621], 'reflect': [5631], 'specific': [5633], 'Recent': [5645], 'synapse': [5649], '(27Evergren': [5650], 'Tomilin': [5652], 'Vasylieva': [5654], 'Sergeeva': [5656], 'V.': [5657], 'Bloom': [5658], 'O.': [5659, 5665, 6060], 'Gad': [5660], 'Capani': [5662], 'F.': [5663], 'Shupliakov': [5664], 'Neurosci.': [5667], 'Methods.': [5668], '135:': [5670], '169-174Crossref': [5671], '(30)': [5674], 'earlier': [5679, 5764], 'nonneuronal': [5682], 'present': [5707], 'coated': [5709, 5743, 5767], 'pits': [5710], 'earliest': [5713], 'stages': [5714, 5765], 'maturation.': [5718, 5771], 'multiple': [5722], 'SH3': [5723], 'domain-containing': [5724], 'molecules,': [5726], 'outset': [5736], 'emerging': [5742], 'pit.': [5744], 'regulating': [5754], 'itself': [5758], 'partner': [5761], 'pit': [5768], 'formation': [5769, 5964], 'Further': [5772], 'will': [5774, 6164], 'needed': [5776, 6166], 'regulated': [5784], 'regulate': [5787], 'several': [5799], 'mutually': [5801], 'exclusive': [5802], 'possibilities': [5803], 'driving': [5823], 'mediate': [5830], 'membrane': [5831], 'fission': [5832, 5876], '6Stowell': [5846], 'Alternatively,': [5865], 'dismantle': [5874], 'machinery': [5877], 'trigger': [5891], 'disassembly': [5894], '(21Maeda': [5897], '28Warnock': [5918], '1996;': [5927], '271:': [5928], '22310-22314Abstract': [5929], '(208)': [5937], 'interpretation': [5942], 'single': [5960, 6025], 'round': [5961], '(29Miwako': [5967], 'Schroter': [5969], 'Traffic.': [5973], '4:': [5975], '376-389Crossref': [5976], '(86)': [5979], 'precedence': [5984], 'model': [5987], 'Sar,': [6006], 'Arf,': [6007], 'SRP54,': [6008], 'SRP': [6010], 'receptor,': [6011], 'able': [6022], 'support': [6024], 'rounds': [6026], '(30Matsuoka': [6031], 'Orci': [6033, 6063], 'L.': [6034, 6064], 'Amherdt': [6035, 6067], 'Bednarek': [6037], 'S.Y.': [6038], 'Hamamoto': [6039], 'Schekman': [6041], 'Yeung': [6043], '1998;': [6046], '93:': [6047], '263-275Abstract': [6048], '(502)': [6056], '31Kuge': [6059], 'Dascher': [6061], 'Rowe': [6065], 'Plutner': [6069], 'Ravazzola': [6071], 'Tanigawa': [6073], 'Rothman': [6075], 'Balch': [6077], 'W.E.': [6078], '125:': [6083], '51-65Crossref': [6084], '(254)': [6087], '32Pepperkok': [6090], 'Whitney': [6092], 'J.A.': [6093], 'Gomez': [6094], 'Kreis': [6096], '113:': [6102], '135-144PubMed': [6103], '33Legate': [6106], 'K.R.': [6107], 'Falcone': [6108], 'Andrews': [6110], 'D.W.': [6111], '275:': [6116], '27439-27446Abstract': [6117], '34Schwartz': [6126], 'Blobel': [6128], '112:': [6132], '793-803Abstract': [6133], '(78)': [6141], 'acute': [6149], 'vivo,': [6156], 'opposed': [6158], 'long': [6160], 'term': [6161], 'experiments,': [6163], 'resolve': [6168], 'issues.': [6170], 'addition,': [6172], 'generation': [6174], 'classes': [6179], 'selectively': [6183], 'grateful': [6196], 'Alisa': [6198], 'Jones': [6199], 'Tricia': [6201], 'Glenn': [6202], 'technical': [6204], 'assistance': [6205], 'expression': [6208], 'purification.': [6210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034067409', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-10T03:04:14.295636', 'created_date': '2016-06-24'}