Publication Information

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4174, 4259, 4275, 4357, 4369, 4413, 4418, 4505, 4601, 4616, 4666, 4678, 4755, 4768, 4861, 4879, 4918, 5055, 5094, 5202, 5261, 5285, 5361, 5387, 5405, 5492], 'angiogenesis,': [7, 213, 881, 1200, 1418, 2476], 'we': [8, 214, 1419, 1436, 2477, 2804, 3639, 3898, 3960, 4069, 4086, 4538, 5342], 'have': [9, 215, 635, 1192, 1279, 1420, 2478, 4902], 'studied': [10, 216, 1421, 2479, 3900, 4539], 'effect': [12, 218, 1423, 2481, 2753, 2807, 3021, 3644, 3714, 3902, 3963, 4001, 4089, 4541, 4553, 5132], 'lipoxygenase': [14, 30, 220, 236, 505], 'metabolites': [15, 31, 221, 237, 763, 1427, 2485, 2533, 3560, 4912, 5041, 5399], 'arachidonic': [17, 33, 223, 239, 758, 1429, 1448, 2487, 2535, 3562, 4747, 4914, 5043, 5145, 5184, 5401, 5457], 'acid': [18, 34, 37, 224, 240, 243, 587, 759, 1430, 1705, 1741, 2488, 2536, 4748, 4915, 5044, 5051, 5146, 5275, 5402, 5458], 'on': [19, 225, 1431, 1714, 1887, 1896, 2012, 2308, 2340, 2420, 2489, 2699, 2756, 2784, 2846, 3024, 3125, 3647, 3717, 3905, 3993, 4002, 4092, 4542, 4554, 5137, 5368], 'human': [20, 226, 523], 'microvascular': [21, 227, 524], 'endothelial': [22, 228, 525, 539, 1050, 1074, 1080, 1622, 1652, 4498, 5295, 5466], 'cell': [23, 229, 768, 1081, 1289, 1354, 1696, 1720, 2015, 2314, 2582, 2723, 3071, 3152, 3239, 3492, 3574, 3631, 3637, 3677, 4023, 4188, 4383, 4922, 5057, 5203], '(HMVEC)': [24, 230], 'DNA': [25, 40, 69, 75, 120, 168, 231, 246, 275, 281, 326, 374, 1433, 1451, 2421, 2491, 2509, 2541, 2557, 2938, 3026, 3039, 3208, 3418, 3445, 3907, 3913, 3934, 3995, 4004, 4055, 4257, 4299, 4604, 4635, 4643, 4664, 4693, 4753, 4786, 4792, 4829, 4877], 'synthesis.': [26, 232, 1434, 2492, 3908, 3996], 'Among': [27, 233, 2530, 4486, 4742], 'various': [29, 235, 767, 947, 2483, 2593], 'tested,': [35, 241, 2537], '5(S)-hydroxyeicosatetraenoic': [36, 242, 520], '(5(S)-HETE)': [38, 244], 'induced': [39, 77, 122, 143, 245, 283, 328, 349, 2540, 4054, 4559, 4752, 4794, 4846, 4857], 'synthesis': [41, 76, 121, 169, 247, 282, 327, 375, 1452, 2422, 2510, 2542, 3027, 3419, 3446, 3914, 3935, 4005, 4056, 4258, 4300, 4636, 4644, 4665, 4694, 4754, 4793, 4878], 'HMVEC.': [43, 171, 205, 249, 377, 411, 3001, 3055, 3133, 3214, 3421, 4358, 4667, 4880], '5(S)-HETE': [44, 82, 142, 177, 203, 250, 288, 348, 383, 409, 2539, 2574, 2612, 2645, 2677, 2698, 2755, 2783, 2900, 2966, 2999, 3063, 3223, 3285, 3429, 3476, 3646, 3659, 3695, 3716, 3859, 4053, 4145, 4171, 4272, 4330, 4366, 4527, 4558, 4613, 4675, 4750, 4758, 4798, 4848, 4856, 4885, 5104, 5134, 5349, 5382, 5449, 5475], 'also': [45, 117, 192, 251, 323, 398, 939, 2686, 3930, 5032, 5151, 5476], 'stimulated': [46, 83, 252, 289, 2613, 3696, 3860, 4759, 4799], 'Jak-2,': [47, 63, 253, 269, 2604, 2617, 3046, 3202, 4134, 4764, 4780], 'STAT-1,': [48, 254, 2605, 2618, 2661, 3047, 4765], 'and': [49, 53, 68, 74, 88, 96, 98, 105, 108, 114, 131, 140, 156, 183, 198, 255, 259, 274, 280, 294, 302, 304, 311, 314, 320, 337, 346, 362, 389, 404, 425, 440, 533, 551, 565, 588, 760, 889, 954, 1047, 1072, 1083, 1092, 1248, 1291, 1356, 1455, 1462, 1479, 1486, 1499, 1525, 1529, 1554, 1576, 1581, 1601, 1659, 1667, 1691, 1706, 1742, 1763, 1878, 2004, 2048, 2095, 2112, 2131, 2152, 2177, 2186, 2219, 2246, 2258, 2295, 2300, 2343, 2376, 2458, 2498, 2508, 2572, 2581, 2592, 2606, 2619, 2637, 2647, 2682, 2704, 2711, 2722, 2733, 2746, 2761, 2791, 2801, 2812, 2898, 2906, 2915, 2927, 3048, 3061, 3070, 3083, 3094, 3123, 3130, 3139, 3151, 3164, 3174, 3207, 3221, 3229, 3238, 3251, 3283, 3291, 3300, 3312, 3325, 3336, 3427, 3435, 3444, 3556, 3566, 3657, 3663, 3671, 3676, 3687, 3700, 3844, 3870, 3886, 3947, 4025, 4027, 4059, 4067, 4096, 4108, 4115, 4140, 4158, 4169, 4177, 4187, 4200, 4215, 4263, 4270, 4278, 4292, 4298, 4341, 4350, 4364, 4372, 4382, 4396, 4407, 4434, 4449, 4492, 4500, 4547, 4584, 4590, 4611, 4619, 4634, 4673, 4681, 4692, 4766, 4776, 4785, 4791, 4802, 4814, 4818, 4824, 4834, 4844, 4864, 4891, 4910, 5037, 5048, 5099, 5283, 5291, 5363, 5372], 'STAT-3': [50, 73, 256, 279, 1558, 2607, 2620, 2638, 2747, 2762, 2792, 2862, 2877, 2886, 2942, 2990, 3049, 3131, 3212, 3321, 4767, 4790], 'tyrosine': [51, 66, 257, 272, 1231, 2601, 2614, 2633, 2668, 2742, 2757, 2787, 2847, 2859, 2874, 2887, 3043, 3126, 3205, 4761, 4783], 'phosphorylation': [52, 67, 89, 132, 258, 273, 295, 338, 2602, 2615, 2634, 2669, 2701, 2743, 2758, 2788, 2848, 2860, 2875, 2888, 2951, 3044, 3127, 3206, 3719, 3862, 3878, 4097, 4117, 4150, 4217, 4342, 4451, 4762, 4784, 4803, 4836], 'STAT-3-DNA': [54, 260, 2957, 2982, 3006], 'binding': [55, 70, 261, 276, 2939, 2958, 3007, 3209, 4787], 'activity.': [56, 262, 3008, 3694], 'Tyrphostin': [57, 263], 'AG490,': [58, 264, 2809, 4773], 'a': [59, 154, 161, 194, 265, 360, 367, 400, 414, 432, 600, 646, 877, 941, 1197, 1227, 1240, 1349, 1639, 1726, 1755, 1769, 1835, 1897, 1939, 2222, 2353, 2622, 2629, 2663, 2810, 2869, 2946, 2953, 2978, 3051, 3101, 3181, 3198, 3266, 3571, 3669, 3925, 3969, 4129, 4161, 4353, 4487, 4551, 4769, 4774, 4862, 4868, 4919, 5461], 'specific': [60, 266, 2813, 3672, 4777, 4820], 'inhibitor': [61, 267, 2814, 3200, 3673, 3927, 3971, 4778], 'significantly': [64, 270, 2765, 2856, 3003, 3036, 3910, 3931, 4751], 'reduced': [65, 271, 4782], 'activity': [71, 87, 130, 277, 293, 336, 1934, 2118, 2940, 2959, 3210, 3633, 3698, 4095, 4107, 4340, 4410, 4788, 4801, 4833, 5054], 'by': [78, 123, 284, 329, 1649, 1693, 1827, 1894, 2019, 2066, 2121, 2167, 2191, 2267, 2318, 2338, 2391, 2435, 2513, 2543, 2738, 2878, 2932, 3088, 3169, 3256, 3331, 3379, 3449, 3706, 4122, 4144, 4205, 4303, 4439, 4564, 4582, 4639, 4648, 4697, 4795, 4847, 4853, 5103], '5(S)-HETE.': [79, 124, 285, 330, 2879], 'In': [80, 159, 286, 365, 630, 1184, 2448, 2657, 2971, 3547, 4571, 5027, 5256, 5338, 5442], 'addition,': [81, 160, 287, 366, 631, 2972, 4572], 'phosphatidylinositol': [84, 290, 528, 1340, 1480], '3-kinase': [85, 291, 1341], '(PI3-kinase)': [86, 292], 'its': [91, 297, 589, 761, 2667, 2891, 2950, 3262, 4099, 4141, 4540, 4805], 'downstream': [92, 298, 3722, 4100, 4142, 4806], 'targets': [93, 299, 4143], 'Akt,': [94, 134, 300, 340, 3864, 3880, 4109, 4152, 4209, 4344, 4443, 4808, 4838], 'p70S6K,': [95, 135, 301, 341, 3865, 3881, 4110, 4153, 4210, 4345, 4444, 4809, 4839], '4E-BP1': [97, 303, 3813], 'their': [99, 305, 2609, 2749, 3097, 3177, 4219, 4453, 5200, 5259], 'effector': [100, 306], 'molecules': [101, 307, 634, 5484], 'ribosomal': [102, 136, 308, 342, 3795, 3866, 3882, 4111, 4154, 4211, 4248, 4346, 4445, 4810, 4840], 'protein': [103, 137, 309, 343, 1520, 1807, 1818, 1833, 2031, 2045, 2074, 2335, 2589, 2730, 2924, 3078, 3159, 3246, 3309, 3370, 3684, 3796, 3867, 3883, 4112, 4155, 4195, 4212, 4249, 4347, 4391, 4429, 4446, 4811, 4841], 'S6': [104, 310, 1521, 3797], 'eIF4E.': [106, 141, 312, 347, 3887], 'LY294002': [107, 313, 1485, 3666, 3707, 3874, 3904, 3909, 3946, 4180, 4281, 4817], 'rapamycin,': [109, 315, 4819], 'potent': [110, 316, 2811, 3199, 3670, 3926, 3970, 4288, 4495, 4775, 5462], 'inhibitors': [111, 317, 4289, 4587, 4821], 'PI3-kinase': [113, 129, 199, 319, 335, 405, 1933, 2452, 3693, 3697, 3721, 4032, 4094, 4106, 4139, 4262, 4339, 4800, 4823, 4832], 'mTOR,': [115, 321, 3929, 4293, 4825], 'respectively,': [116, 322, 554, 4294, 4826], 'blocked': [118, 166, 324, 372, 3932, 4827, 4875], 'Interestingly,': [125, 331, 4102], 'AG490': [126, 332, 2851, 2909, 3002, 3023, 3035, 3232, 3294, 3438, 4091, 4123, 4375, 4583], 'attenuated': [127, 333, 4581], '5(S)-HETE-induced': [128, 167, 334, 373, 2556, 3005, 3017, 3025, 3038, 3204, 3417, 3895, 3906, 3912, 3933, 3958, 4093, 4103, 4573, 4602, 4642, 4663, 4828, 4876], 'S6,': [138, 344, 3868, 3884, 4113, 4156, 4213, 4348, 4447, 4812, 4842], '4E-BP1,': [139, 345, 3869, 3885, 4114, 4157, 4214, 4349, 4448, 4813, 4843], 'expression': [145, 187, 351, 393, 1466, 4534, 4544, 4556, 4561, 4574, 4858, 4895, 5278, 5352], 'basic': [147, 353, 514], 'fibroblast': [148, 354, 515, 1068], 'growth': [149, 180, 355, 386, 437, 516, 540, 1069, 1075, 1290, 1357, 4530, 4888, 4917, 5157, 5204, 5360], 'factor': [150, 356, 517, 1070, 1076], '2': [151, 357, 1625, 1655, 1872, 1982, 1998, 2060, 2137, 2146, 2523, 2913, 2963, 3298, 3355, 3459, 4313], '(bFGF-2)': [152, 358], 'Jak-2-': [155, 182, 361, 388, 1461, 4863, 4890], 'PI3-kinase-dependent': [157, 184, 363, 390, 1463, 4162, 4865, 4892], 'manner.': [158, 364, 4163], 'neutralizing': [162, 368, 1577, 4622, 4649, 4684, 4869], 'anti-bFGF-2': [163, 369, 4623, 4650, 4657, 4685, 4870], 'antibody': [164, 370, 4874], 'completely': [165, 371, 3704, 3875, 4646], 'Together': [172, 378], 'these': [173, 379, 632, 2648, 2683, 4080, 5375], 'results': [174, 380, 2867, 4127, 4882], 'suggest': [175, 381, 2868, 4128, 4883], 'that': [176, 382, 757, 1078, 1194, 1233, 1442, 2768, 2778, 3553, 3985, 4017, 4884, 4904, 5034, 5177, 5348, 5381, 5396, 5459, 5489], 'stimulates': [178, 384, 1450, 3042, 4021, 4149, 4528, 4886, 5357], 'HMVEC': [179, 385, 1432, 1611, 1665, 1785, 2251, 2490, 2494, 2568, 2597, 2707, 2894, 3018, 3057, 3135, 3217, 3279, 3423, 3653, 3896, 3916, 3937, 4007, 4058, 4165, 4260, 4266, 4360, 4529, 4603, 4669, 4887], 'via': [181, 387, 502, 560, 1234, 1460, 4531, 4889, 5190], 'induction': [185, 391, 1464, 4532, 4893], 'bFGF-2.': [189, 395, 1468, 4897], 'These': [190, 396, 2866, 4126, 4881], 'findings': [191, 397, 4733, 5176], 'reveal': [193, 399], 'cross-talk': [195, 401, 4078], 'between': [196, 402, 4079], 'Jak-2': [197, 403, 2636, 2703, 2745, 2760, 2790, 2799, 2816, 2872, 3129, 4066, 4356, 4589, 5371], 'response': [201, 407, 430, 644, 2997, 3702], 'to': [202, 408, 431, 638, 645, 1207, 1282, 1347, 1661, 1709, 1938, 2235, 2352, 2444, 2890, 2998, 3338, 3361, 3641, 4072, 4420, 4851, 5154, 5258, 5472], 'Arachidonic': [412, 586], 'acid,': [413, 417, 1449, 3563, 3569, 5185], 'polyunsaturated': [415], 'fatty': [416], 'is': [418, 426, 499, 1458, 2467, 3634, 4076, 5366, 5379, 5460], 'an': [419, 883, 2078, 3488, 4502, 5358, 5384], 'important': [420, 884, 3489, 4503, 4732, 5385], 'component': [421], 'membrane': [423, 558, 2355, 2383], 'phospholipids': [424, 559], 'acutely': [427], 'released': [428], 'variety': [433, 601, 4488, 4920], 'agonists,': [435], 'including': [436, 605, 770, 4924], 'factors,': [438, 1244, 4490, 4537], 'cytokines,': [439], 'hormones': [441], '(1Piomelli': [442, 568], 'D.': [443, 455, 569, 716, 919, 930, 984, 995, 1122, 1133, 1385, 3521, 3752, 4508, 5212], 'Curr.': [444, 570, 1374, 3510, 3741], 'Opin.': [445, 571], 'Cell': [446, 459, 572, 845, 1536, 2329, 4999], 'Biol.': [447, 573, 657, 676, 745, 797, 822, 858, 1298, 1333, 1375, 1390, 1800, 1959, 3511, 3526, 3584, 3742, 3757, 3775, 3790, 3808, 3823, 3839, 4951, 4976, 5012, 5067, 5240, 5311, 5332, 5416], '1993;': [448, 574, 692, 5171], '5:': [449, 575], '274-280Google': [450, 576], 'Scholar,': [451, 464, 481, 577, 615, 662, 681, 695, 708, 730, 787, 802, 812, 827, 837, 850, 863, 928, 993, 1002, 1010, 1031, 1131, 1140, 1148, 1169, 1264, 1303, 1321, 1367, 1379, 1394, 3503, 3515, 3530, 3588, 3612, 3734, 3746, 3779, 3828, 4515, 4941, 4956, 4966, 4981, 4991, 5004, 5017, 5071, 5244, 5316, 5421, 5431], '2Dethlefsen': [452], 'S.M.': [453, 1024, 1162], 'Shepro': [454], "D'Amore": [456], 'P.A.': [457], 'Exp.': [458], 'Res.': [460, 625, 808, 1041, 1179, 4962, 5427], '1994;': [461, 478, 492, 626, 678, 1028, 1166, 1261, 1961], '212:': [462], '262-273Google': [463], '3Gronich': [465], 'J.': [466, 475, 491, 581, 611, 656, 675, 702, 726, 780, 781, 796, 821, 843, 844, 857, 867, 915, 932, 980, 997, 1004, 1026, 1058, 1118, 1135, 1142, 1164, 1297, 1317, 1332, 1363, 1799, 1955, 1958, 3499, 3579, 3600, 3608, 3730, 3781, 3785, 3799, 3803, 3822, 4510, 4517, 4934, 4935, 4950, 4975, 4997, 4998, 5011, 5021, 5062, 5116, 5124, 5222, 5310, 5331, 5415], 'Konieczkowski': [467], 'M.': [468, 619, 710, 720, 734, 903, 905, 968, 970, 1106, 1108, 1399, 2818, 2822, 3535, 3590, 3594, 3766, 5106, 5110, 5206, 5216, 5229, 5322], 'Gelb': [469], 'M.H.': [470, 718, 732, 5214, 5227], 'Nemenoff': [471], 'R.A.': [472, 1296], 'Sedor': [473], 'J.R.': [474, 5307], 'Clin.': [476], 'Invest.': [477], '93:': [479, 3627, 5086], '1224-1233Google': [480], '4Rao': [482], 'G.N.': [483, 664, 1790, 5318], 'Lassegue': [484], 'B.': [485, 1359, 3495, 3726, 3849], 'Alexander': [486, 673], 'R.W.': [487, 674], 'Griendling': [488], 'K.K.': [489], 'Biochem.': [490, 580, 610, 1362, 3498, 3729, 3854], '299:': [493], '197-201Google': [494], 'Scholar).': [495, 585, 629, 749, 872, 937, 1045, 1064, 1183, 1223, 1277, 1338, 1410, 1805, 1964, 3546, 3629, 3858, 4051, 4523, 5026, 5088, 5128, 5174, 5255, 5337, 5441], 'Upon': [496], 'release,': [497], 'it': [498, 3550, 4028, 5030, 5100, 5378], 'either': [500, 3109], 'metabolized': [501], 'cyclooxygenase,': [504], '(LOX),': [506], '1The': [507], 'abbreviations': [508], 'used': [509, 1660, 4238, 4472], 'are:': [510], 'LOX,': [511, 4906], 'lipoxygenase;': [512], 'bFGF-2,': [513], '2;': [518], '5(S)-HETE,': [519, 1443, 1492], 'acid;': [521], 'HMVEC,': [522, 1454, 5362], 'cells;': [526], 'PI3-kinase,': [527, 3675, 4068, 4291, 4591], '3-kinase;': [529], 'STAT,': [530], 'signal': [531, 1246], 'transducer': [532], 'activator': [534], 'transcription;': [536], 'VEGF,': [537], 'vascular': [538, 606, 1073], 'factor.': [541], 'or': [542, 555, 1783, 2717, 2771, 3111, 3146, 4284, 4626, 4686], 'cytochrome': [543, 3557, 4907, 5038], 'P450': [544, 3558, 4908, 5039], 'monooxygenase': [545, 3559, 5040], 'pathways': [546], 'producing': [547], 'prostaglandins,': [548], 'hydroperoxyeicosatetraenoic': [549], 'acids,': [550, 553], 'epoxyeicosatrienoic': [552], 'reincorporated': [556], 'into': [557, 2302], 'esterification': [561], 'involving': [562], 'arachidonoyl-CoA': [563], 'synthetase': [564], 'arachidonoyl-lysophospholipid': [566], 'transferase': [567], '5Smith': [578], 'W.L.': [579, 609], '1989;': [582, 612], '259:': [583, 613], '315-324Google': [584, 614], 'metabolites,': [590], 'known': [591, 879], 'as': [592, 880, 951, 1067, 1786, 2038, 2425, 2945, 4416, 4739, 5046, 5148, 5271, 5450, 5486], 'eicosanoids,': [593, 5178], 'are': [594, 1052, 1205, 1226, 2423, 2793, 3403, 4494, 4738, 5403, 5470, 5490], 'involved': [595, 1088, 1284, 5404, 5491], 'regulation': [598, 1287], 'biological': [603], 'processes': [604, 1094], 'tone': [607], '(5Smith': [608], '6Lin': [616], 'L.': [617, 839, 901, 917, 966, 982, 1104, 1120, 1325, 1397, 3533, 4993, 5324], 'Balazy': [618], 'Pagano': [620], 'P.J.': [621], 'Nasjletti': [622], 'A.': [623, 653, 814, 907, 923, 972, 988, 1039, 1110, 1126, 1177, 1213, 1381, 2832, 2841, 3517, 3592, 3606, 3625, 3748, 3764, 3979, 4968, 5084, 5108, 5122, 5299], 'Circ.': [624, 1040, 1178], '74:': [627, 693, 5172], '197-205Google': [628], 'lipid': [633], 'been': [636, 1280, 1345, 5152], 'reported': [637, 1193, 1281, 1346, 3552, 4903, 5033], 'mediate': [639, 5155, 5186], 'intracellular': [640], 'signaling': [641, 2553, 5188, 5264], 'events': [642, 1054, 2554, 5189, 5265], 'number': [647, 4899], 'stimuli': [649], '(7Graber': [650], 'M.N.': [651], 'Alfonso': [652], 'Gill': [654], 'D.L.': [655], 'Chem.': [658, 677, 798, 823, 859, 1299, 1334, 1801, 1960, 3824, 4952, 4977, 5013, 5312, 5333, 5417], '1996;': [659, 925, 934, 990, 999, 1128, 1137, 3626, 3791, 3809, 4512, 5085], '271:': [660], '883-888Google': [661], '8Rao': [663], 'Baas': [665], 'A.S.': [666], 'Glasgow': [667], 'W.C.': [668, 789, 4943, 5408], 'Eling': [669, 794, 4948, 5327, 5413], 'T.E.': [670, 795, 4949, 5328, 5414], 'Runge': [671], 'M.S.': [672], '269:': [679, 1962], '32586-32591Google': [680], '9Peppelenbosch': [682], 'M.P.': [683, 5162], 'Tertoolen': [684, 5163], 'L.G.': [685, 5164], 'Hage': [686, 5165], 'W.J.': [687, 5166], 'de': [688, 5167], 'Laat': [689, 5168], 'S.W.': [690, 5169], 'Cell.': [691, 703, 744, 782, 933, 998, 1136, 1389, 3525, 3583, 3756, 3774, 3789, 3807, 3838, 4511, 4936, 5066, 5170, 5239], '565-575Google': [694, 5173], '10Fafeur': [696], 'V.': [697, 895, 960, 1098, 4036], 'Jiang': [698, 1326], 'Z.P.': [699], 'Bohlen': [700], 'P.': [701, 893, 958, 1033, 1096, 1171, 1369, 2830, 3505, 3736], 'Physiol.': [704, 783, 868, 4937, 5022], '1991;': [705, 727, 746, 824, 1042, 1180, 4978, 5223, 5241, 5252], '149:': [706], '277-283Google': [707], '11Golubic': [709], 'Tanaka': [711, 5207], 'K.': [712, 909, 974, 1112, 1309, 1311, 2820, 3830, 5208], 'Dobrowolski': [713, 735, 5209, 5230], 'S.': [714, 804, 831, 899, 964, 1102, 2840, 3624, 3832, 4044, 4958, 4985, 5083, 5210, 5423, 5435], 'Wood': [715, 5211], 'Tsai': [717, 5213], 'Marshall': [719, 5215], 'Tamanoi': [721, 5217], 'F.': [722, 1037, 1175, 3975, 4046, 5218, 5248, 5301], 'Stacey': [723, 741, 5219, 5236], 'D.W.': [724, 742, 5220, 5237], 'EMBO': [725, 1316, 5221], '10:': [728, 5224], '2897-2903Google': [729, 5225], '12Tsai': [731], 'Roudebush': [733, 5228], 'S.,': [736, 5231], 'Yu,': [737, 5232], 'C.L.': [738, 3977, 5233], 'Gibbs': [739, 5234], 'J.B.': [740, 1022, 1160, 5235], 'Mol.': [743, 1388, 3524, 3582, 3755, 3773, 3788, 3806, 3837, 5065, 5238], '11:': [747, 5242], '2785-2793Google': [748, 5243], 'A': [750, 2626, 3966, 3998, 4898, 5389], 'large': [751, 5390], 'body': [752, 5391], 'pharmacological': [754, 1190, 5393], 'data': [755, 2466, 5394], 'suggests': [756, 2777, 2986], 'eicosanoid': [762], 'stimulate': [764, 4916], 'mitogenesis': [765], 'types,': [769, 4923], 'cancer': [771, 4925], 'cells': [772, 1051, 1683, 1968, 2515, 3451, 4305, 4499, 4607, 4699, 4926, 5290], '(13Harris': [773, 4927], 'R.C.': [774, 3581, 4928, 5064], 'Homma': [775, 4929], 'T.': [776, 1020, 1158, 1305, 1307, 1315, 1373, 2828, 3509, 3740, 4930], 'Jacobson': [777, 4931], 'H.R.': [778, 4932], 'Capdevila': [779, 3578, 4933, 5061], '1990;': [784, 834, 4938, 4988, 5438], '144:': [785, 4939], '429-437Google': [786, 4940], '14Glasgow': [788, 4942], 'Afshari': [790, 4944, 5409], 'C.A.': [791, 4945, 5410], 'Barrett': [792, 4946, 5411], 'J.C.': [793, 4947, 5412], '1992;': [799, 809, 4953, 4963, 5418, 5428], '267:': [800, 4954, 5419], '10771-10779Google': [801, 4955, 5420], '15Shimakura': [803, 4957, 5422], 'Boland': [805, 4959, 5424], 'C.R.': [806, 4960, 5425], 'Cancer': [807, 832, 4961, 4986, 5426, 5436], '52:': [810, 4964, 5429], '1744-1749Google': [811, 4965, 5430], '16Sellmayer': [813, 4967], 'Uedelhoven': [815, 4969], 'W.M.': [816, 1383, 3519, 3750, 4970], 'Weber': [817, 4971], 'P.C.': [818, 4972], 'Bonventre': [819, 4973], 'J.V.': [820, 4974], '266:': [825, 4979], '3800-3807Google': [826, 4980], '17Ralph': [828, 4982, 5432], 'R.K.': [829, 4983, 5433], 'Wojcik': [830, 4984, 5434], 'Lett.': [833, 4987, 5437], '49:': [835, 4989, 5439], '181-185Google': [836, 4990, 5440], '18Palmberg': [838, 4992], 'Claesson': [840, 4994], 'H.E.': [841, 4995], 'Thyberg': [842, 4996], 'Sci.': [846, 2838, 3622, 5000, 5081], '1987;': [847, 860, 5001, 5014], '88:': [848, 5002], '151-159Google': [849, 5003], '19Setty': [851, 5005], 'B.N.': [852, 5006], 'Graeber': [853, 5007], 'J.E.': [854, 1255, 1271, 5008], 'Stuart': [855, 5009], 'M.J.': [856, 1798, 5010], '262:': [861, 5015], '17613-17622Google': [862, 5016], '20Owen': [864, 5018], 'N.E.': [865, 5019], 'Am.': [866, 1025, 1163, 5020], '1986;': [869, 5023], '250:': [870, 5024], 'C584-C588Google': [871, 5025], 'Formation': [873], 'new': [875], 'capillaries,': [876], 'process': [878], 'plays': [882, 940, 3487, 5383], 'embryonic': [887, 1090], 'development': [888, 1091], 'wound': [890], 'healing': [891], '(21Carmeliet': [892, 957, 1095], 'Ferreira': [894, 959, 1097], 'Breier': [896, 961, 1099], 'G.': [897, 962, 1100, 1405, 3541, 3604, 3772, 5120], 'Pollefeyt': [898, 963, 1101], 'Kieckens': [900, 965, 1103], 'Gertsenstein': [902, 967, 1105], 'Fahrig': [904, 969, 1107], 'Vandenhoeck': [906, 971, 1109], 'Harpal': [908, 973, 1111], 'Eberhardt': [910, 975, 1113], 'C.': [911, 913, 976, 978, 1114, 1116, 1215, 1217, 1401, 2824, 2826, 3537, 3598, 5114], 'Declercq': [912, 977, 1115], 'Pawling': [914, 979, 1117], 'Moons': [916, 981, 1119], 'Collen': [918, 983, 1121], 'Risau': [920, 985, 1123], 'W.': [921, 986, 1124], 'Nagy': [922, 987, 1125], 'Nature.': [924, 989, 1127], '380:': [926, 991, 1129], '435-439Google': [927, 992, 1130], '22Hanahan': [929, 994, 1132], 'Folkman': [931, 996, 1134, 4509], '86:': [935, 1000, 1138, 4513], '353-364Google': [936, 1001, 1139, 4514], 'Angiogenesis': [938], 'progression': [945], 'proliferative': [948], 'diseases': [949], 'such': [950, 1066, 5045, 5147, 5270, 5485], 'atherosclerosis,': [952], 'cancer,': [953], 'diabetic': [955], 'retinopathy': [956], '23Folkman': [1003, 1141, 4516], 'Nat.': [1005, 1059, 1143, 1218, 4518], 'Med.': [1006, 1060, 1144, 1219, 4519], '1995;': [1007, 1061, 1145, 1274, 4520], '1:': [1008, 1062, 1146, 4521], '27-31Google': [1009, 1063, 1147, 4522], "24O'Brien": [1011, 1149], 'E.R.': [1012, 1150], 'Garvin': [1013, 1151], 'M.R.': [1014, 1152], 'Dev': [1015, 1153], 'R.': [1016, 1154, 1371, 1403, 3507, 3539, 3602, 3738, 3783, 3801, 4040, 5118], 'Stewart': [1017, 1155], 'D.K.': [1018, 1156], 'Hinohara': [1019, 1157], 'Simpson': [1021, 1159], 'Schwartz': [1023, 1161], 'Pathol.': [1027, 1165], '145:': [1029, 1167], '883-894Google': [1030, 1168], '25Cuevas': [1032, 1170], 'Gonzalez': [1034, 1172], 'A.M.': [1035, 1173], 'Carceller': [1036, 1174], 'Baird': [1038, 1176], '69:': [1043, 1181], '360-369Google': [1044, 1182], 'Proliferation': [1046], 'motility': [1048, 1084], 'essential': [1053], 'angiogenesis': [1056, 4506], '(23Folkman': [1057], 'Factors': [1065], '(FGF)': [1071], '(VEGF)': [1077], 'influence': [1079], 'proliferation': [1082], 'are,': [1085], 'therefore,': [1086, 3950], 'likely': [1087, 5380], 'disease': [1093], 'recent': [1185, 3548, 5028], 'years,': [1186, 3549, 5029], 'some': [1187, 5056, 5268], 'studies': [1188, 4012, 4901, 5469], 'using': [1189, 1815, 1901, 1922, 2403, 2608, 2748, 3096, 3176, 3261, 4218, 4452], 'approaches': [1191], 'play': [1196, 1348, 3570, 4501], 'although': [1201], 'underlying': [1203], 'mechanisms': [1204], 'yet': [1206], 'be': [1208, 1283, 2445], 'investigated': [1209], '(26Dormond': [1210], 'O.': [1211, 4042], 'Foletti': [1212], 'Paroz': [1214], 'Ruegg': [1216], '2001;': [1220, 3585, 3609, 3981, 4048, 5068, 5125], '7:': [1221], '1041-1047Google': [1222], 'Janus': [1224], 'kinases': [1225, 1232], 'group': [1228, 1241], 'non-receptor': [1230], 'phosphorylating': [1235], 'modulate': [1236, 5052], 'activities': [1238, 5481], 'transcriptional': [1243], 'namely': [1245], 'transducers': [1247], 'activators': [1249], 'transcription': [1251], '(STATs)': [1252], '(27Darnell': [1253], 'Jr.,': [1254, 1270, 1944], 'Kerr': [1256], 'I.M.': [1257], 'Stark': [1258], 'G.R.': [1259, 3817], 'Science.': [1260, 1406, 3542, 5251], '264:': [1262], '1415-1421Google': [1263], '28Horvath': [1265], 'C.M.': [1266], 'Wen': [1267], 'Z.': [1268], 'Darnell': [1269], 'Genes': [1272], 'Dev.': [1273], '9:': [1275], '984-994Google': [1276], 'STATs': [1278], 'differentiation': [1292], '(29Wu': [1293], 'Y.Y.': [1294], 'Bradshaw': [1295], '2000;': [1300, 1364, 3500, 3731, 3825], '275:': [1301, 3826], '2147-2156Google': [1302], '30Nosaka': [1304], 'Kawashima': [1306], 'Misawa': [1308], 'Ikuta': [1310], 'Mui': [1312], 'A.L.': [1313], 'Kitamura': [1314], '1999;': [1318, 1802, 3776, 3840, 3855, 5334], '18:': [1319], '4754-4765Google': [1320], '31Zong': [1322], 'C.S.': [1323], 'Zeng': [1324], 'Y.': [1327, 1796], 'Sadowski': [1328], 'H.B.': [1329], 'Wang': [1330, 1948], 'L.H.': [1331], '1998;': [1335, 1376, 3512, 3743], '273:': [1336], '28065-28072Google': [1337], 'Similarly,': [1339], '(PI3-kinase)/Akt': [1342], 'pathway': [1343, 2564, 3015, 3486, 3956], 'has': [1344], 'major': [1350], 'agonist-induced': [1353], 'survival': [1355, 3493, 3575, 3632, 4024, 5053], '(32Vanhaesebroeck': [1358, 3494, 3725], 'Alessi': [1360, 3496, 3727], 'D.R.': [1361, 3497, 3728], '346:': [1365, 3501, 3732], '561-576Google': [1366, 3502, 3733], '33Blume-Jensen': [1368, 3504, 3735], 'Janknecht': [1370, 3506, 3737], 'Hunter': [1372, 3508, 3739], '8:': [1377, 3513, 3744], '779-782Google': [1378, 3514, 3745], '34Klippel': [1380, 3516, 3747], 'Kavanaugh': [1382, 3518, 3749], 'Pot': [1384, 3520, 3751], 'Williams': [1386, 3522, 3753], 'L.T.': [1387, 3523, 3754], '1997;': [1391, 1407, 2842, 3527, 3543, 3758], '17:': [1392, 3528, 3759], '338-344Google': [1393, 3529, 3760], '35del': [1395, 3531], 'Peso': [1396, 3532], 'Gonzalez-Garcia': [1398, 3534], 'Page': [1400, 3536], 'Herrera': [1402, 3538], 'Nunez': [1404, 3540], '278:': [1408, 3544], '687-689Google': [1409, 3545], 'LOX': [1426, 2484, 2532, 3555, 4744, 5036, 5181, 5398, 5454], 'Here,': [1435], 'report': [1437, 4016], 'for': [1438, 1557, 1656, 1677, 1716, 1884, 2009, 2024, 2059, 2077, 2157, 2196, 2240, 2310, 2323, 2505, 2520, 2577, 2600, 2652, 2688, 2719, 2741, 2871, 2912, 2937, 3066, 3091, 3148, 3172, 3235, 3259, 3297, 3354, 3441, 3456, 3636, 3692, 4131, 4183, 4208, 4239, 4295, 4310, 4355, 4378, 4442, 4473, 4497, 4631, 4689, 4704, 5199, 5344, 5464], 'first': [1440, 3372, 5346], 'time': [1441, 5347], '5-LOX': [1445, 5091, 5142], 'metabolite': [1446], 'this': [1456, 3701, 3920, 4060, 5364, 5443], 'event': [1457], 'mediated': [1459], 'Aprotinin,': [1469], 'dithiothreitol,': [1470, 1865, 1990], 'phenylmethylsulfonyl': [1471, 1861, 2007, 2287], 'fluoride,': [1472, 1862, 2288], 'sodium': [1473, 1475, 2281, 2298, 2371], 'orthovanadate,': [1474], 'deoxycholate,': [1476, 2282], 'leupeptin,': [1477, 2000, 2294], 'HEPES,': [1478, 1845, 1979], 'were': [1481, 1488, 1502, 1533, 1544, 1561, 1583, 1605, 1612, 1619, 1633, 1647, 1671, 1684, 1779, 1825, 1892, 1918, 1969, 2017, 2083, 2189, 2252, 2265, 2316, 2336, 2349, 2401, 2412, 2433, 2442, 2495, 2569, 2584, 2598, 2650, 2685, 2708, 2725, 2736, 2895, 2918, 2930, 3058, 3073, 3086, 3106, 3136, 3154, 3167, 3218, 3241, 3254, 3280, 3303, 3315, 3329, 3346, 3424, 3654, 3679, 3690, 4070, 4118, 4166, 4190, 4203, 4267, 4361, 4385, 4399, 4437, 4608, 4670, 4849], 'purchased': [1482, 1545], 'from': [1483, 1490, 1504, 1535, 1546, 1563, 1584, 1596, 1607, 1614, 1781, 2046, 2590, 2731, 2925, 3081, 3162, 3249, 3310, 3685, 4013, 4198, 4394, 4432], 'Sigma.': [1484], 'rapamycin': [1487, 3922, 3948, 4285], 'obtained': [1489, 1534, 1562, 1606], 'Calbiochem.': [1491], '12(S)-HETE,': [1493], '15(S)-HETE,': [1494], 'leukotriene': [1495, 1497, 1500, 5149], 'B4,': [1496], 'C4,': [1498], 'D4': [1501], 'bought': [1503, 1613], 'Cayman': [1505], 'Chemicals': [1506], '(Ann': [1507], 'Arbor,': [1508], 'MI).': [1509], 'Phospho-specific': [1510, 1540], 'anti-Akt': [1511, 1531, 4231, 4465], '(9271),': [1512], 'anti-4E-BP1': [1513], '(9451),': [1514], 'anti-eIF4E': [1515], '(9741),': [1516], 'anti-p70S6K': [1517], '(9205),': [1518], 'anti-ribosomal': [1519], '(2211),': [1522], 'anti-STAT-1': [1523], '(9171S),': [1524], 'anti-STAT-3': [1526, 2975, 3112, 3275, 3352], '(9131S)': [1527], 'antibodies': [1528, 1532, 1543, 1553, 1578, 2058, 2389, 2976, 3353, 4232, 4466, 4630, 4654, 4661, 4688], 'normal': [1530], 'Signaling': [1537], 'Technology(Beverly,': [1538], 'MA).': [1539], 'anti-Jak-2': [1541, 3110, 3190], '(44–426Z)': [1542], 'BIOSOURCE': [1547], 'International': [1548], '(Camarillo,': [1549], 'CA).': [1550, 1570], 'Anti-Jak-2': [1551], '(SC-294)': [1552], 'consensus': [1555, 2943, 3322], 'oligonucleotides': [1556, 1917], '(5′-GATCCTTCTGGGAATTCCTAGATC-3′)': [1559], '(SC-2571)': [1560], 'Santa': [1564], 'Cruz': [1565], 'Biotechnology,': [1566, 1586], 'Inc.': [1567, 1587], '(Santa': [1568], 'Cruz,': [1569], 'Anti-PI3-kinase': [1571], '(06–195),': [1572], 'anti-bFGF-2,': [1573], 'anti-VEGF': [1574, 4627, 4653, 4660, 4687, 4873], 'antibodies,': [1575, 4406], 'bFGF-2': [1580, 4491, 4546, 4563, 4576, 4600, 4860, 5282, 5354], 'VEGF': [1582, 4493, 4555, 4579, 5284], 'Upstate': [1585], '(Lake': [1588], 'Placid,': [1589], 'NY).': [1590], 'T4': [1591, 1924], 'polynucleotide': [1592, 1925], 'kinase': [1593, 1926, 2117, 4409], 'was': [1594, 1698, 1723, 1734, 1751, 1766, 1813, 1935, 2036, 2051, 2119, 2165, 2206, 2233, 2384, 2511, 2565, 2639, 2671, 2763, 2960, 3028, 3187, 3272, 3371, 3447, 3551, 3703, 4227, 4237, 4301, 4411, 4461, 4471, 4580, 4637, 4645, 4695, 5031, 5101, 5135], 'procured': [1595], 'Invitrogen.': [1597], '[γ-32P]ATP': [1598, 1921, 2156], '(3000': [1599], 'Ci/mmol)': [1600, 1604], '[3H]thymidine': [1602, 1676, 2519, 3455, 4309, 4640, 4703], '(20': [1603, 1977], 'PerkinElmer': [1608], 'Life': [1609], 'Sciences.': [1610], 'Clonetics': [1615], '(Walkersville,': [1616], 'MD).': [1617], 'Cells': [1618, 1646, 2264], 'grown': [1620], 'basal': [1623, 1653], 'medium': [1624, 1654], '(CC-3156)': [1626], 'containing': [1627, 1759, 2202, 2331, 2368], 'EGM-2': [1628], 'MV': [1629], 'SingleQuots': [1630], '(CC-4147).': [1631], 'Cultures': [1632], 'maintained': [1634], 'at': [1635, 2021, 2027, 2062, 2160, 2193, 2243, 2320, 2326, 2641, 2653, 2673, 2689, 2852, 2962], '37': [1636], '°C': [1637, 2064, 2245], 'humidified': [1640], '95%': [1641], 'air,': [1642], '5%': [1643, 1739, 2377], 'CO2': [1644], 'atmosphere.': [1645], 'growth-arrested': [1648, 3216, 3278], 'incubating': [1650, 1828, 2132], '24': [1657, 2506, 3442, 4296, 4632, 4690], 'h': [1658, 2061, 2242, 2524, 2964, 3356, 3460, 4314, 4691, 4708], 'perform': [1662], 'experiments.': [1664], 'with': [1666, 1673, 1686, 1737, 1744, 1920, 2053, 2068, 2087, 2092, 2098, 2133, 2215, 2254, 2386, 2393, 2416, 2497, 2516, 2571, 2680, 2710, 2897, 2949, 3060, 3108, 3138, 3189, 3220, 3274, 3282, 3317, 3348, 3374, 3381, 3426, 3452, 3656, 3919, 4168, 4230, 4241, 4269, 4306, 4363, 4401, 4464, 4475, 4567, 4610, 4672, 4700], 'without': [1668, 2499, 2573, 2712, 2899, 3062, 3140, 3222, 3284, 3428, 3658, 4170, 4271, 4365, 4612, 4674], 'appropriate': [1669, 1966, 2249, 2387], 'treatments': [1670], 'pulse-labeled': [1672], '1': [1674, 1856, 1859, 1863, 1972, 1988, 1991, 2109, 2292, 2296, 2500, 2517, 2655, 2691, 2713, 3141, 3349, 3453, 4307, 4701], 'μCi/ml': [1675, 2518, 3454, 4308, 4702], 'indicated': [1679, 2503, 2579, 3068, 4185, 4244, 4380, 4478], 'times.': [1680], 'After': [1681, 1712, 1965, 2248, 2306, 2359], 'labeling,': [1682], 'washed': [1685, 1735, 2084], 'cold': [1687, 1701, 1738, 1745, 2255, 3376], 'phosphate-buffered': [1688, 2256], 'saline,': [1689, 2276], 'trypsinized,': [1690], 'collected': [1692], 'centrifugation.': [1694], 'The': [1695, 1732, 1749, 1806, 1889, 2014, 2030, 2081, 2116, 2163, 2184, 2199, 2230, 2347, 2398, 2430, 2752, 3484, 4731, 5175], 'pellet': [1697], 'suspended': [1699], '10%': [1702, 1996, 2344], '(w/v)': [1703, 2073, 2378], 'trichloroacetic': [1704, 1740], 'vortexed': [1707], 'vigorously': [1708], 'lyse': [1710], 'cells.': [1711, 5467], 'standing': [1713, 2307], 'ice': [1715, 2309], '20': [1717, 1839, 2010, 2153, 2171, 2311, 2324], 'min,': [1718, 2721, 3150, 3237], 'lysis': [1721, 1975, 2088, 2273], 'mixture': [1722], 'passed': [1724], 'through': [1725], 'glass': [1727], 'fiber': [1728], 'filter': [1729, 1733, 1750], '(GF/C,': [1730], 'Whatman).': [1731], 'once': [1736, 1743], '70%': [1746], '(v/v)': [1747], 'ethanol.': [1748], 'dried,': [1752], 'placed': [1753], 'liquid': [1756, 1770, 2262], 'scintillation': [1757, 1771], 'vial': [1758], 'scintillant': [1761], 'fluid,': [1762], 'radioactivity': [1765], 'measured': [1767, 1936, 2120, 2512, 3448, 4302, 4412, 4638, 4696], 'counter': [1772], '(LS': [1773], '5000TA,': [1774], 'Beckman': [1775], 'Instruments).': [1776], 'Nuclear': [1777], 'extracts': [1778, 1812, 2583, 2724, 2917, 3072, 3153, 3240, 3302, 3678, 4189, 4384], 'prepared': [1780], 'treated': [1782, 2385, 2496, 2570, 2709, 2896, 3059, 3137, 3219, 3281, 3425, 3655, 4167, 4268, 4362, 4609, 4671], 'untreated': [1784], 'described': [1787, 2039, 4417], 'previously': [1788, 1940], '(36Rao': [1789], 'Katki': [1791], 'K.A.': [1792], 'Madamanchi': [1793, 5319], 'N.R.,': [1794], 'Wu,': [1795], 'Birrer': [1797], '274:': [1803, 5335], '6003-6010Google': [1804], 'content': [1808, 2032], 'nuclear': [1811, 1832, 2916, 2923, 3301, 3308, 3369], 'determined': [1814, 2037], 'Micro': [1816], 'BCATM': [1817], 'assay': [1819, 2936, 3335], 'reagent': [1820, 2405], 'kit': [1821, 1927, 2406], '(Pierce).': [1822], 'Protein-DNA': [1823], 'complexes': [1824, 1891, 2400, 3328, 3345, 3360], 'formed': [1826, 2995], '5': [1829, 2054, 2174, 2642, 2674, 3236], 'μg': [1830, 1867, 1873, 3350, 4403], 'total': [1836], 'volume': [1837], 'μl': [1840, 2055, 2070, 2127, 2135, 2141, 2147, 2172, 2179, 2271], 'consisting': [1841, 2225], '15': [1843, 2025], 'mm': [1844, 1849, 1854, 1857, 1860, 1864, 1906, 1911, 1914, 1978, 1983, 1986, 1989, 2102, 2107, 2110, 2144, 2150, 2297, 2363, 2370], 'pH': [1846, 1851, 1908, 1980, 2104, 2366], '7.9,': [1847, 1852], '3': [1848, 2085, 2090, 2096, 4402], 'Tris-HCl,': [1850, 1907], '60': [1853], 'KCl,': [1855], 'EDTA,': [1858, 2111], '4.5': [1866], 'bovine': [1869], 'serum': [1870], 'albumin,': [1871], 'poly(dI-dC),': [1875], '15%': [1876], 'glycerol,': [1877, 1997], '100,000': [1879, 3318], 'cpm': [1880, 3319], 'of32P-labeled': [1881, 3320], 'oligonucleotide': [1882, 2944, 3323], 'probe': [1883], '30': [1885, 2126, 2720, 3149], 'min': [1886, 2011, 2026, 2159, 2312, 2325, 2643, 2675], 'ice.': [1888, 2013], 'protein-DNA': [1890, 2993], 'resolved': [1893, 2337], 'electrophoresis': [1895, 2339], '4%': [1898], 'polyacrylamide': [1899, 2345], 'gel': [1900, 2210], '1×': [1902], 'Tris-glycine-EDTA': [1903], 'buffer': [1904, 1976, 2100, 2130, 2274], '(25': [1905, 2910, 3233, 3295, 3439, 3667, 4181, 4282, 4376], '8.5,': [1909], '200': [1910, 2178], 'glycine,': [1912], '0.1': [1913], 'EDTA).': [1915], 'Double-stranded': [1916], 'labeled': [1919, 3382], '(Invitrogen)': [1928], 'following': [1929], "supplier's": [1931], 'protocol.': [1932], 'according': [1937], 'published': [1941], 'protocol': [1942], '(37Myers': [1943], 'M.G.': [1945], 'Grammer': [1946], 'T.C.': [1947], 'L.M.': [1949], 'Sun': [1950], 'X.J.': [1951], 'Pierce': [1952], 'J.H.': [1953], 'Blenis': [1954, 3784, 3802], 'White': [1956], 'M.F.': [1957], '28783-28789Google': [1963], 'treatments,': [1967, 2250], 'lysed': [1970, 2266], 'ml': [1973], '7.4,': [1981, 2105], 'EGTA,': [1984], '50': [1985], 'β-glycerophosphate,': [1987], 'mmNa3VO4,': [1992], '1%': [1993, 2216, 2277], 'Triton': [1994], 'X-100,': [1995], 'μm': [1999, 2006, 2114, 2501, 2714, 2854, 3142], '10': [2001, 2106, 2113, 2134, 2140, 2158, 2197, 2362], 'units/ml': [2002], 'aprotinin,': [2003, 2291], '400': [2005], 'fluoride)': [2008], 'lysates': [2016, 2315, 2330], 'cleared': [2018, 2317], 'centrifugation': [2020, 2192, 2319], '12,000': [2022, 2321], 'rpm': [2023, 2195, 2322], '4': [2028, 2063, 2327, 2864, 2969], '°C.': [2029, 2162, 2328], 'supernatants': [2035], 'above.': [2040], 'Five': [2041, 3305], 'hundred': [2042], 'micrograms': [2043, 3306], 'control': [2047, 2547, 2591, 2732, 2926, 3082, 3163, 3250, 3311, 3686, 4199, 4395, 4433, 4568], 'each': [2049, 2734, 2928, 3084, 3165, 3252, 3313, 3688, 4201, 4397, 4435], 'treatment': [2050, 2431, 2678, 2735, 2929, 2967, 3085, 3166, 3253, 3314, 3464, 3477, 3689, 4202, 4318, 4331, 4398, 4436, 4712, 4724], 'immunoprecipitated': [2052, 4400], 'anti-PI3-kinase': [2057, 4405], 'followed': [2065, 2390, 3378], 'incubation': [2067, 2392, 2528, 3380], '40': [2069], '50%': [2072, 4121], 'A-Sepharose': [2075], 'beads': [2076], 'additional': [2079, 5197], 'hour.': [2080], 'immunoprecipitates': [2082, 2124], 'times': [2086, 2091, 2097, 2415, 2594], 'buffer,': [2089, 2094, 2365], 'wash': [2093], 'TNE': [2099, 2129], '(10': [2101], 'Tris-Cl,': [2103], 'NaCl,': [2108], 'Na3VO4).': [2115], 'resuspending': [2122], 'mg/ml': [2138], 'phosphatidylinositol,': [2139], '100': [2143, 2149, 2285, 2289], 'MgCl2,': [2145], 'ATP,': [2151], 'μCi': [2154], '22': [2161], 'reaction': [2164], 'terminated': [2166], 'addition': [2169, 5257], 'n': [2175], 'HCl': [2176], 'chloroform:methanol': [2181], '(1:1)': [2182], 'mix.': [2183], 'aqueous': [2185], 'organic': [2187, 2200], 'phases': [2188], 'separated': [2190, 2220, 3330], '2000': [2194], 'min.': [2198], 'phase': [2201], 'phosphoinositide': [2204], 'phosphates': [2205], 'spotted': [2207], 'onto': [2208], 'silica': [2209], '60A': [2211], 'TLC': [2212, 2231], 'plate': [2213, 2232], 'coated': [2214], 'potassium': [2217], 'oxalate': [2218], 'solvent': [2223], 'system': [2224], 'chloroform:methanol:water:ammonium': [2227], 'hydroxide': [2228], '(90:70:14.6:5.4).': [2229], 'exposed': [2234], 'X-Omat': [2236], 'AR': [2237], 'x-ray': [2238], 'film': [2239], '4–6': [2241], '−80': [2244], 'developed.': [2247], 'rinsed': [2253], 'saline': [2257], 'frozen': [2259], 'immediately': [2260], 'nitrogen.': [2263], 'thawing': [2268], '250': [2270], '(phosphate-buffered': [2275], 'Nonidet': [2278], 'P-40,': [2279], '0.5%': [2280], '0.1%': [2283, 2341, 2373], 'SDS,': [2284], 'μg/ml': [2286, 2290, 2293], 'orthovanadate)': [2299], 'scraped': [2301], '1.5-ml': [2303], 'Eppendorf': [2304], 'tubes.': [2305], 'equal': [2332, 4388, 4426], 'amounts': [2333, 2587, 2728, 2921, 3076, 3157, 3244, 3682, 4193, 4389, 4427], 'SDS': [2342], 'gels.': [2346], 'proteins': [2348, 5195], 'transferred': [2350], 'electrophoretically': [2351], 'nitrocellulose': [2354], '(Hybond,': [2356], 'Amersham': [2357], 'Biosciences).': [2358, 2408], 'blocking': [2360], 'Tris-HCl': [2364], '8.0,': [2367], '150': [2369], 'chloride,': [2372], 'Tween': [2374], '20,': [2375], 'nonfat': [2379], 'dry': [2380], 'milk,': [2381], 'primary': [2388], 'horseradish': [2394], 'peroxidase-conjugated': [2395], 'secondary': [2396], 'antibodies.': [2397, 2611, 2751, 3099, 3179, 3264, 3276, 4221, 4455], 'antigen-antibody': [2399], 'detected': [2402], 'chemiluminescence': [2404], '(Amersham': [2407], 'All': [2409], 'experiments': [2411], 'repeated': [2413], 'three': [2414], 'similar': [2417], 'results.': [2418], 'Data': [2419], 'presented': [2424], 'mean': [2427], '±': [2428], 'S.D.': [2429], 'effects': [2432, 2781, 3944], 'analyzed': [2434, 2599, 2737, 2931, 3087, 3168, 3255, 4204, 4438], "Student'st": [2436], 'test.': [2437], 'p': [2438, 3467, 4321, 4715, 4720], 'values': [2439], '<': [2440, 3468, 3473, 4322, 4327, 4716, 4721], '0.05': [2441], 'considered': [2443], 'statistically': [2446], 'significant.': [2447], 'case': [2450, 2659], 'activity,': [2453], 'electrophoretic': [2454, 2933, 3332, 3362], 'mobility': [2455, 2934, 3333, 3363], 'shift': [2456, 2935, 3334, 3364], 'assay,': [2457], 'Western': [2459, 2739, 3089, 3170, 3257, 4206, 4440], 'blot': [2460, 3186, 3271, 4226, 4236, 4460, 4470], 'analysis,': [2461, 3342, 3368], 'one': [2462, 5451], 'representative': [2463], 'set': [2464], 'shown.': [2468], 'Quiescent': [2493, 2567, 3652], 'h,': [2507, 2914, 3299, 3443, 4297, 4633], 'pulse-labeling': [2514, 3450, 4304, 4698], 'last': [2522, 3458, 4312, 4706], '24-h': [2527, 3463, 4317, 4711], 'period.': [2529, 3465, 4319, 4713], 'only': [2538, 2662, 4229, 4463], 'about': [2544, 4120], '80%': [2545], 'over': [2546], '(Fig.': [2548, 2773, 2863, 2968, 3708, 3872, 3938, 4124, 4569, 4593], '1).': [2549], 'learn': [2551, 4073], 'synthesis,': [2558, 4605], 'Jak/STAT': [2563, 3014], 'studied.': [2566, 3029], '(1': [2575, 2901, 3064, 3224, 3286, 3430, 3967, 4172, 4273, 4367, 4614, 4676], 'μm)': [2576, 2902, 2911, 3065, 3225, 3234, 3287, 3296, 3431, 3440, 4173, 4182, 4274, 4283, 4368, 4377, 4615, 4677], 'times,': [2580, 3069, 4186, 4381], 'prepared.': [2585, 2726, 2919, 3074, 3155, 3242, 3304, 3680, 4191, 4386], 'Equal': [2586, 2727, 2920, 3075, 3156, 3243, 3681, 4192], '5(S)-HETE-treated': [2596], 'phospho-specific': [2610, 2750, 3098, 3178, 3263, 4220, 4245, 4454, 4479], 'time-dependent': [2623, 3052, 4770], 'manner': [2624, 3053], '(Fig.2).': [2625], 'maximum': [2627], '2–3-fold': [2630], 'increase': [2631, 2665, 2955], 'observed': [2640, 2672, 2780, 2961], 'treatment,': [2646], 'levels': [2649, 2670, 5479], 'sustained': [2651, 2687], 'least': [2654, 2690], 'h.': [2656, 2692], 'slight': [2664], 'compared': [2679, 4566], 'control,': [2681, 3103, 3183, 3268, 4224, 4458], 'increases': [2684, 2884, 4104], 'test': [2694, 3889, 4525, 4596], 'specificity': [2696], 'STAT-3,': [2705, 2803], 'quiescent': [2706, 2893, 4606], '5(S)-,': [2715, 3121, 3144], '12(S)-': [2716, 2770], '15(S)-HETE': [2718, 2772, 3124, 3147], 'blotting': [2740, 3090, 3171, 3258, 4207, 4441], 'found': [2764], 'higher': [2766], 'than': [2767], '3).': [2774], 'This': [2775, 2984], 'result': [2776, 2985], 'stimulation': [2785], 'relatively': [2794], 'specific.': [2795], 'find': [2797, 3010], 'whether': [2798, 2882, 4074, 4526, 5474], 'phosphorylates': [2800], 'activates': [2802], 'tested': [2805, 3712, 3961, 4087], '(38Nielsen': [2817], 'Kaltoft': [2819], 'Nordahl': [2821], 'Ropke': [2823], 'Geisler': [2825], 'Mustelin': [2827], 'Dobson': [2829], 'Svejgaard': [2831], 'Odum': [2833], 'N.': [2834, 3836, 3851, 5305, 5330], 'Proc.': [2835, 3619, 5078], 'Natl.': [2836, 3620, 5079], 'Acad.': [2837, 3621, 5080], 'U.': [2839, 3623, 5082], '94:': [2843], '6764-6769Google': [2844], 'Scholar),': [2845, 3761, 3794, 3812, 3843], 'STAT-3.': [2850], '25': [2853], 'concentration': [2855], 'inhibited': [2857, 3004, 3037, 3705, 3876, 3911, 4119, 4647], '5(S)-HETE-stimulated': [2858, 3877, 3994, 4003], 'A).': [2865], 'investigate': [2881], 'lead': [2889], 'activation,': [2892], 'presence': [2905, 2988, 3228, 3290, 3434, 3662, 4176, 4277, 4371, 4618, 4680], 'absence': [2907, 3230, 3292, 3436, 3664, 4178, 4279, 4373, 4620, 4682], 'using32P-labeled': [2941], 'probe.': [2947], 'Consistent': [2948, 3918], 'state,': [2952], '2-fold': [2954], 'B).': [2970], 'use': [2973], 'caused': [2977, 5092], 'supershift': [2979, 3341], 'complex.': [2983], 'complex': [2994], 'growth,': [3019, 3638, 3897, 3959, 4026], 'As': [3030, 3100, 3180, 3265], 'shown': [3031, 3404, 5153], 'Fig.': [3033, 4421], '5,': [3034], 'synthesis.Figure': [3040], '25(S)-HETE': [3041], 'Growth-arrested': [3056, 3134, 3422, 4164, 4359, 4668], '(40': [3079, 3160, 3247, 4196, 4430], 'μg)': [3080, 3161, 3248, 4197, 4393, 4431], 'pJak-2,': [3092], 'pSTAT-1,': [3093], 'pSTAT-3': [3095, 3175, 3260], 'loading': [3102, 3182, 3267, 4223, 4457], 'blots': [3105], 'reprobed': [3107, 3188, 3273, 4228, 4462], 'antibodies.View': [3113, 3191, 4480], 'Large': [3114, 3192, 3410, 3479, 4251, 4333, 4481, 4726], 'Image': [3115, 3193, 3411, 3480, 4252, 4334, 4482, 4727], 'Figure': [3116, 3194, 3412, 3481, 4253, 4335, 4483, 4728], 'ViewerDownload': [3117, 3195, 3413, 3482, 4254, 4336, 4484, 4729], '(PPT)Figure': [3118, 3196, 3414, 4255, 4337], '3Effects': [3119], '12(S)-,': [3122, 3145], 'pJak-2': [3173], 'same': [3185, 3270, 4235, 4469], '4AG490,': [3197], 'reduces': [3203], 'A,': [3215, 4387], 'B,': [3277, 4425], 'incubated': [3316, 3347, 3373], 'probe,': [3324], 'DNA-protein': [3327, 3344], 'subjected': [3337], 'autoradiography.': [3339], 'For': [3340, 3366, 3384, 4222, 4456], 'before': [3357], 'subjecting': [3358], 'assay.': [3365], 'competitive': [3367], 'excessive': [3375], 'oligos': [3377], 'oligos.': [3383], 'clarity': [3385], 'appearance': [3388], 'supershifts,': [3390], 'longer': [3391], 'exposure': [3392], 'autoradiographic': [3393], 'signals': [3394], 'respective': [3397], 'lanes': [3398], 'left': [3401], 'panel': [3402], 'right': [3406], 'panel.': [3407], 'Ab,': [3408], 'antibody.View': [3409], '5AG490': [3415], 'inhibits': [3416], '*,': [3466, 4320, 4714], '0.01': [3469, 3474, 4323, 4328, 4717, 4722], 'versus': [3470, 3475, 4324, 4329], 'control;': [3471, 4325], '**,p': [3472, 4326], 'alone.View': [3478, 4332, 4725], '(PPT)': [3483, 4485, 4730], 'PI3-kinase/Akt': [3485, 3650, 3893, 3955, 3991], 'particularly,': [3564], '12(S)-HETE': [3565, 5047], '14,': [3567, 5049], '15-epoxyeicosatrienoic': [3568, 5050], '(39Chen': [3576, 5059], 'J.K.': [3577, 5060], 'Harris': [3580, 5063], '21:': [3586, 5069], '6322-6331Google': [3587, 5070], '40Romano': [3589], 'Catalano': [3591, 5107], 'Nutini': [3593, 5109], "D'Urbano": [3595, 5111], 'E.': [3596, 5112], 'Crescenzi': [3597, 5113], 'Claria': [3599, 5115], 'Libner': [3601, 5117], 'Davi': [3603, 5119], 'Procopio': [3605, 5121], 'FASEB': [3607, 5123], '13:': [3610, 5126], '2326-2336Google': [3611, 5127], '41Tang': [3613, 5072], 'D.G.': [3614, 5073], 'Chen': [3615, 5074], 'Y.Q.': [3616, 5075], 'Honn': [3617, 5076], 'K.V.': [3618, 5077], '5241-5246Google': [3628, 5087], 'Because': [3630, 4052], 'required': [3635, 4062, 5471], 'wanted': [3640], 'study': [3642, 4737, 5341, 5447], 'activation': [3648, 4030, 4063, 4137, 5369], 'signaling.': [3651], 'μm),': [3668, 3968], 'assayed': [3691], '2-fold,': [3699], '6).': [3709], 'We': [3710], 'next': [3711, 3899], 'targets,': [3723], 'Akt': [3724], 'p70S6K': [3762, 4264], '(42Dufner': [3763], 'Andjelkovic': [3765], 'Burgering': [3767], 'B.M.': [3768], 'Hemmings': [3769], 'B.A.': [3770], 'Thomas': [3771], '19:': [3777, 3841], '4525-4534Google': [3778], '43Dahl': [3780], 'Freund': [3782, 3800], 'Benjamin': [3786, 3804], 'T.L.': [3787, 3805], '16:': [3792, 3810], '2728-2735Google': [3793, 3811], '(43Dahl': [3798], '(44Herbert': [3814], 'T.P.': [3815], 'Kilhams': [3816], 'Batty': [3818], 'I.H.': [3819], 'Proud': [3820], 'C.G.': [3821], '11249-11256Google': [3827], '45Khaleghpour': [3829], 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