Publication Information

{'id': 'https://openalex.org/W2094863524', 'doi': 'https://doi.org/10.1016/0305-0491(89)90121-1', 'title': 'Factors that regulate the activity of the phosphatidylinositol kinase present in oocyte membranes of Xenopus laevis', 'display_name': 'Factors that regulate the activity of the phosphatidylinositol kinase present in oocyte membranes of Xenopus laevis', 'publication_year': 1989, 'publication_date': '1989-01-01', 'ids': {'openalex': 'https://openalex.org/W2094863524', 'doi': 'https://doi.org/10.1016/0305-0491(89)90121-1', 'mag': '2094863524', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2539941'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0305-0491(89)90121-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210171413', 'display_name': 'Comparative Biochemistry and Physiology Part B Comparative Biochemistry', 'issn_l': '0305-0491', 'issn': ['0305-0491'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102814475', 'display_name': 'Daniel E. Carrasco', 'orcid': 'https://orcid.org/0009-0004-0258-4107'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Daniel Carrasco', 'raw_affiliation_strings': ['Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103847571', 'display_name': 'Catherine C. Allende', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Catherine C. Allende', 'raw_affiliation_strings': ['Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032017828', 'display_name': 'Jorge E. Allende', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Jorge E. Allende', 'raw_affiliation_strings': ['Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Facultad de Medicina, and Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 70086, Santiago 7, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.626, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.532357, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 66}, 'biblio': {'volume': '92', 'issue': '3', 'first_page': '487', 'last_page': '491'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Mechanosensitive Ion Channels in Physiology and Disease', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin Function and Regulation in Vertebrates', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pleckstrin-homology-domain', 'display_name': 'Pleckstrin homology domain', 'score': 0.60851973}, {'id': 'https://openalex.org/keywords/membrane', 'display_name': 'membrane', 'score': 0.436202}], 'concepts': [{'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.96956944}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.8286847}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.64489937}, {'id': 'https://openalex.org/C49658373', 'wikidata': 'https://www.wikidata.org/wiki/Q24776397', 'display_name': 'Pleckstrin homology domain', 'level': 3, 'score': 0.60851973}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5848351}, {'id': 'https://openalex.org/C2776690073', 'wikidata': 'https://www.wikidata.org/wiki/Q3246226', 'display_name': 'Oocyte', 'level': 3, 'score': 0.58238083}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5094481}, {'id': 'https://openalex.org/C2779637612', 'wikidata': 'https://www.wikidata.org/wiki/Q2354337', 'display_name': 'Phosphatidylserine', 'level': 4, 'score': 0.45843866}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4474398}, {'id': 'https://openalex.org/C118716', 'wikidata': 'https://www.wikidata.org/wiki/Q5514725', 'display_name': "GTP'", 'level': 3, 'score': 0.44053626}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4082118}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.3951702}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3541292}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.302881}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.27913082}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.042218745}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010770', 'descriptor_name': 'Phosphotransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019870', 'descriptor_name': '1-Phosphatidylinositol 4-Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019794', 'descriptor_name': '2,3-Diphosphoglycerate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004163', 'descriptor_name': 'Diphosphoglyceric Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004163', 'descriptor_name': 'Diphosphoglyceric Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008345', 'descriptor_name': 'Manganese', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008345', 'descriptor_name': 'Manganese', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010716', 'descriptor_name': 'Phosphatidylinositols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010770', 'descriptor_name': 'Phosphotransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010770', 'descriptor_name': 'Phosphotransferases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0305-0491(89)90121-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210171413', 'display_name': 'Comparative Biochemistry and Physiology Part B Comparative Biochemistry', 'issn_l': '0305-0491', 'issn': ['0305-0491'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2539941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.4, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1485449921', 'https://openalex.org/W1495556880', 'https://openalex.org/W1508687963', 'https://openalex.org/W1512440304', 'https://openalex.org/W1534587066', 'https://openalex.org/W1865486468', 'https://openalex.org/W1966586618', 'https://openalex.org/W1986694073', 'https://openalex.org/W2003171166', 'https://openalex.org/W2009439652', 'https://openalex.org/W2011844277', 'https://openalex.org/W2039619279', 'https://openalex.org/W2060983889', 'https://openalex.org/W2065505790', 'https://openalex.org/W2074571771', 'https://openalex.org/W2077815159', 'https://openalex.org/W2136189765', 'https://openalex.org/W2338315462'], 'related_works': ['https://openalex.org/W2171787368', 'https://openalex.org/W2136545008', 'https://openalex.org/W2094863524', 'https://openalex.org/W2052537837', 'https://openalex.org/W2052062680', 'https://openalex.org/W1987012315', 'https://openalex.org/W1986361815', 'https://openalex.org/W1980708345', 'https://openalex.org/W1968053546', 'https://openalex.org/W1606823008'], 'abstract_inverted_index': {'1.': [0], 'Phosphatidylinositol': [1], 'kinase': [2, 37], 'present': [3], 'in': [4], 'the': [5, 29, 50, 61, 76], 'membranes': [6], 'of': [7, 31, 52, 56, 63, 75], 'Xenopus': [8], 'laevis': [9], 'oocytes': [10], 'was': [11], 'characterized.': [12], '2.': [13], 'The': [14, 34], 'enzyme': [15], 'requires': [16], 'Mg2+': [17], 'or': [18], 'Mn2+': [19], 'at': [20, 67], '10': [21], 'mM': [22, 69], 'and': [23, 58], 'exogenous': [24], 'phosphatidylinositol': [25, 36, 64], '(50': [26], 'μM)': [27], 'increases': [28], 'formation': [30], 'phosphatidylinositol-4-phosphate.': [32], '3.': [33], 'oocyte': [35], 'cannot': [38], 'use': [39], 'GTP': [40], 'as': [41], 'a': [42, 72], 'phosphate': [43], 'donor': [44], 'but': [45, 65], 'this': [46], 'compound': [47], 'inhibits': [48], 'competitively': [49], 'utilization': [51], 'ATP.': [53], '4.': [54], 'Addition': [55], 'phosphatidylserine': [57], 'phosphatidylinositol-4,5-bisphosphate': [59], 'stimulates': [60], 'phosphorylation': [62], '2,3-bisphosphoglycerate': [66], '5': [68], 'concentration': [70], 'is': [71], 'strong': [73], 'inhibitor': [74], 'reaction.': [77]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094863524', 'counts_by_year': [], 'updated_date': '2024-09-26T23:19:05.528172', 'created_date': '2016-06-24'}