Publication Information

{'id': 'https://openalex.org/W2010944339', 'doi': 'https://doi.org/10.1021/jm00062a027', 'title': 'Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate (U-90152S), a second-generation clinical candidate', 'display_name': 'Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate (U-90152S), a second-generation clinical candidate', 'publication_year': 1993, 'publication_date': '1993-05-01', 'ids': {'openalex': 'https://openalex.org/W2010944339', 'doi': 'https://doi.org/10.1021/jm00062a027', 'mag': '2010944339', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7684450'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00062a027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089012257', 'display_name': 'Donna L. Romero', 'orcid': 'https://orcid.org/0000-0002-3009-1965'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna L. Romero', 'raw_affiliation_strings': ['Upjohn Laboratories, Kalamazoo, Michigan 49001.'], 'affiliations': [{'raw_affiliation_string': 'Upjohn Laboratories, Kalamazoo, Michigan 49001.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087927870', 'display_name': 'Raymond A. Morge', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Raymond A. Morge', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015403600', 'display_name': 'Michaël Génin', 'orcid': 'https://orcid.org/0000-0002-9098-7528'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael J. Genin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035595958', 'display_name': 'Carolyn Biles', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Carolyn Biles', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103628167', 'display_name': 'Mariano Busso', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mariano Busso', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045564855', 'display_name': 'Lionel Resnick', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lionel Resnick', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091176402', 'display_name': 'Irene W. Althaus', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Irene W. Althaus', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012840316', 'display_name': 'Fritz Reusser', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fritz Reusser', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113807088', 'display_name': 'Richard C. Thomas', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Richard C. Thomas', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005718849', 'display_name': 'William Tarpley', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'William G. Tarpley', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.76, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 121, 'citation_normalized_percentile': {'value': 0.978882, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '36', 'issue': '10', 'first_page': '1505', 'last_page': '1508'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9814, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/identification', 'display_name': 'Identification', 'score': 0.5449613}, {'id': 'https://openalex.org/keywords/piperazine', 'display_name': 'Piperazine', 'score': 0.44986677}], 'concepts': [{'id': 'https://openalex.org/C2778805511', 'wikidata': 'https://www.wikidata.org/wiki/Q1713', 'display_name': 'Citation', 'level': 2, 'score': 0.601271}, {'id': 'https://openalex.org/C192527728', 'wikidata': 'https://www.wikidata.org/wiki/Q1465700', 'display_name': 'Indole test', 'level': 2, 'score': 0.5553895}, {'id': 'https://openalex.org/C116834253', 'wikidata': 'https://www.wikidata.org/wiki/Q2039217', 'display_name': 'Identification (biology)', 'level': 2, 'score': 0.5449613}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.48214814}, {'id': 'https://openalex.org/C2776201271', 'wikidata': 'https://www.wikidata.org/wiki/Q409292', 'display_name': 'Piperazine', 'level': 2, 'score': 0.44986677}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4374015}, {'id': 'https://openalex.org/C518677369', 'wikidata': 'https://www.wikidata.org/wiki/Q202833', 'display_name': 'Social media', 'level': 2, 'score': 0.41492894}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.4012105}, {'id': 'https://openalex.org/C23123220', 'wikidata': 'https://www.wikidata.org/wiki/Q816826', 'display_name': 'Information retrieval', 'level': 1, 'score': 0.36615515}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.35101902}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.26187992}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14104691}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.10138491}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020008', 'descriptor_name': 'Delavirdine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00062a027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7684450', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032942734', 'https://openalex.org/W2999191546', 'https://openalex.org/W2748952813', 'https://openalex.org/W2463459088', 'https://openalex.org/W2440041482', 'https://openalex.org/W2393939934', 'https://openalex.org/W2187407093', 'https://openalex.org/W2118186952', 'https://openalex.org/W1991310507', 'https://openalex.org/W1966259035'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVArticleNEXTBis(heteroaryl)piperazine': [3], '(BHAP)': [4], 'reverse': [5], 'transcriptase': [6], 'inhibitors:': [7], 'structure-activity': [8], 'relationships': [9], 'of': [10, 18, 84, 119, 145], 'novel': [11], 'substituted': [12], 'indole': [13], 'analogs': [14], 'and': [15, 47, 94, 99, 128, 172, 189, 205, 207], 'the': [16, 81, 112, 117, 146, 157, 170, 173, 178, 185, 191], 'identification': [17], '1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate': [19], '(U-90152S),': [20], 'a': [21, 142, 149, 162], 'second-generation': [22], 'clinical': [23], 'candidateDonna': [24], 'L.': [25], 'Romero,': [26], 'Raymond': [27], 'A.': [28], 'Morge,': [29], 'Michael': [30], 'J.': [31, 52], 'Genin,': [32], 'Carolyn': [33], 'Biles,': [34], 'Mariano': [35], 'Busso,': [36], 'Lionel': [37], 'Resnick,': [38], 'Irene': [39], 'W.': [40], 'Althaus,': [41], 'Fritz': [42], 'Reusser,': [43], 'Richard': [44], 'C.': [45], 'Thomas,': [46], 'William': [48], 'G.': [49], 'TarpleyCite': [50], 'this:': [51], 'Med.': [53], 'Chem.': [54], '1993,': [55], '36,': [56], '10,': [57], '1505–1508Publication': [58], 'Date': [59], '(Print):May': [60], '1,': [61], '1993Publication': [62], 'History': [63], 'Published': [64], 'online1': [65], 'May': [66, 70], '2002Published': [67], 'inissue': [68], '1': [69], '1993https://pubs.acs.org/doi/10.1021/jm00062a027https://doi.org/10.1021/jm00062a027research-articleACS': [71], 'PublicationsRequest': [72], 'reuse': [73], 'permissionsArticle': [74], 'Views554Altmetric-Citations111LEARN': [75], 'ABOUT': [76], 'THESE': [77], 'METRICSArticle': [78], 'Views': [79], 'are': [80, 103, 116], 'COUNTER-compliant': [82], 'sum': [83], 'full': [85], 'text': [86], 'article': [87, 151], 'downloads': [88], 'since': [89], 'November': [90], '2008': [91], '(both': [92], 'PDF': [93], 'HTML)': [95], 'across': [96], 'all': [97], 'institutions': [98], 'individuals.': [100], 'These': [101], 'metrics': [102], 'regularly': [104], 'updated': [105, 129], 'to': [106, 111], 'reflect': [107], 'usage': [108], 'leading': [109], 'up': [110], 'last': [113], 'few': [114], 'days.Citations': [115], 'number': [118], 'other': [120], 'articles': [121], 'citing': [122], 'this': [123], 'article,': [124], 'calculated': [125], 'by': [126], 'Crossref': [127, 135], 'daily.': [130], 'Find': [131, 181], 'more': [132, 182], 'information': [133, 183], 'about': [134, 169], 'citation': [136], 'counts.The': [137], 'Altmetric': [138, 186], 'Attention': [139, 187], 'Score': [140, 188], 'is': [141, 193], 'quantitative': [143], 'measure': [144], 'attention': [147], 'that': [148], 'research': [150], 'has': [152], 'received': [153], 'online.': [154], 'Clicking': [155], 'on': [156, 184], 'donut': [158], 'icon': [159], 'will': [160], 'load': [161], 'page': [163], 'at': [164], 'altmetric.com': [165], 'with': [166, 201], 'additional': [167], 'details': [168], 'score': [171, 192], 'social': [174], 'media': [175], 'presence': [176], 'for': [177], 'given': [179], 'article.': [180], 'how': [190], 'calculated.': [194], 'Share': [195, 210], 'Add': [196], 'toView': [197], 'InAdd': [198], 'Full': [199], 'Text': [200], 'ReferenceAdd': [202], 'Description': [203], 'ExportRISCitationCitation': [204], 'abstractCitation': [206], 'referencesMore': [208], 'Options': [209], 'onFacebookTwitterWechatLinked': [211], 'InRedditEmail': [212], 'Other': [213], 'access': [214], 'optionsGet': [215], 'e-AlertscloseSupporting': [216], 'Info': [217], '(1)»Supporting': [218], 'Information': [219, 221], 'Supporting': [220], 'Get': [222], 'e-Alerts': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2010944339', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-10T22:41:09.799381', 'created_date': '2016-06-24'}