Title: Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis
Abstract: Piperazine-containing compounds serve as one of the most important classes of compounds throughout all fields of chemistry. Alas, current synthetic methods have fallen short of providing a general method for the synthesis of highly decorated piperazine fragments. Herein, we present a site-selective approach to the C-H functionalization of existing piperazine compounds using photoredox catalysis. This manifold relies on the predictable differentiation of electronically distinct nitrogen centers within the piperazine framework, granting access to novel C-alkylated variants of the starting piperazines.
Publication Year: 2020
Publication Date: 2020-01-06
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 55
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