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'experimental': [254, 315, 350, 524, 625, 767], 'animals': [255, 316, 351, 525], 'have': [256, 577, 607], 'shown': [257, 608], 'oppose': [260], 'pressor': [262], 'actions': [263, 403, 803], 'II': [266, 406, 532, 536, 646, 658, 662, 682, 763, 898, 1093, 1165, 1301], '(Ang': [267, 533], 'II)': [268], 'AT1Rs': [270], 'lower': [272], 'blood': [273, 286, 619, 758, 883, 940, 1001, 1123, 1553], 'pressure,': [274], 'especially': [275], 'presence': [278], 'AT1R': [280], 'blockade.2–9': [281], 'AT2R': [283, 311, 345, 396, 416, 432, 464, 494, 521, 561, 695, 719, 751, 795], 'stimulation': [284], 'lowers': [285, 757, 882], 'pressure': [287, 299, 620, 759, 941, 1124, 1228, 1554], 'predominantly': [288], 'under': [289], 'circumstances': [290], 'RAS': [294, 585, 612, 641], 'activated10–13': [296], 'increasing': [298], 'natriuresis.11,13': [300], 'It': [301], 'likely': [303, 503, 631], 'depressor': [306, 1581], 'hypotensive': [308], 'effects': [309, 1005, 1050], 'described': [313, 395], 'translate': [317], 'diseases': [320, 601], 'such': [321, 566, 602, 730], 'as': [322, 327, 371, 437, 502, 558, 567, 586, 603, 696, 731], 'evidenced': [328], 'above-cited': [331], 'work': [332, 539], 'Naso': [336], 'Calo.Our': [338], 'recent': [339], 'study1': [340], 'demonstrates': [341], 'selective': [343, 749], 'renal': [344, 374, 507, 622, 934, 1115, 1146, 1252, 1299], 'induces': [347, 879], 'natriuresis': [348, 445, 880, 1229, 1310], 'inducing': [353], 'proximal': [354, 429, 476, 789, 1340], 'tubule': [355, 430, 477, 1341], 'sodium': [356, 365, 457, 478, 728, 754, 785], 'transporter': [357], 'internalization': [358, 664], 'inactivation.': [360], 'The': [361, 480, 690, 1374, 1580], 'mechanism': [362, 481, 1168], 'transporters': [366], 'inhibited': [368], 'was': [369], 'identified': [370, 498], 'increased': [372, 506, 644], 'AT2R-induced': [373], 'production': [375], 'bradykinin,': [377], 'nitric': [378], 'oxide,': [379], 'cyclic': [381], 'GMP,': [382], 'similar': [383], 'signaling': [386], 'pathway': [387], 'mediating': [388], 'most,': [389], 'if': [390], 'not': [391, 527, 1014], 'all,': [392], 'functions,': [397], 'including': [398], 'vasodilation.14In': [399], 'contrast': [400], 'Ang': [405, 528, 535, 546, 555, 645, 657, 661, 681, 762], 'internalize': [408], 'desensitize': [410], 'AT1Rs,': [411], 'show': [414, 462], 'recruits': [418], 'intracellular': [421], 'compartments': [422], 'apical': [425, 468, 489], 'plasma': [426, 469], 'membranes': [427], 'cells.1': [431], 'recruitment': [433, 465], 'may,': [434], 'therefore,': [435], 'serve': [436], 'a': [438, 587, 675, 697, 747, 1145, 1590], 'reinforcing': [439], 'positive': [440], 'feedback': [441], 'mechanism,': [442], 'sustains': [444], 'response': [447, 492], 'RAS,': [452, 652], 'opposing': [453], 'AT1R-mediated': [454], 'reduction': [455], 'excretion.': [458], 'Studies': [459], 'date': [461], 'membrane': [470, 490], 'requisite': [472], 'inhibition': [474, 931], 'reabsorption.1': [479], 'translocation': [483], 'cytosol': [487], 'has': [496], 'been': [497], 'group': [501], 'be': [505, 710, 722], 'cAMP': [508], 'production.15It': [509], 'important': [511, 614, 712, 1542], 'point': [513], 'out': [514, 579], 'primary/preferred': [517], 'agonist': [518, 562, 1338], 'endogenous': [520, 560], 'II,': [529], 'but': [530, 1013], 'des1-aspartyl-Ang': [531], 'III).16': [534], 'seems': [537], 'primarily': [540], 'or': [541], 'exclusively': [542], 'after': [543], 'conversion': [544], 'III': [547, 556, 1304, 1334], 'action': [550], 'aminopeptidase': [552], 'A.16,17': [553], 'Whether': [554], 'acts': [557], 'an': [559, 711, 1541], 'disorders,': [565], 'awaits': [573, 823], 'further': [574, 824], 'study.Recent': [575], 'pointed': [578], 'importance': [581], 'intrarenal': [584, 611, 640, 680, 703, 1375], 'local': [588], 'tissue': [589], 'functioning': [591], 'independently': [592], 'systemic': [595, 651, 742], 'pathophysiology': [599], 'hypertension.': [604, 736], 'These': [605], 'regulation': [617, 1555], 'function': [623, 1121], 'animals.': [626], 'This': [627, 820], 'concept': [628], 'highly': [630], 'apply': [633], 'also': [634], 'humans.': [636], 'Overactivation': [637], 'leads': [642], 'levels,': [647], 'which,': [648], 'unlike': [649], 'can': [653], 'induce': [654], 'autoamplification': [655], 'production.18–22': [659], 'AT1R-dependent': [660], 'cellular': [663], 'upregulated': [666], 'renin': [667, 1426, 1453], 'synthesized': [668], 'distal': [671, 815], 'nephron': [672, 799], 'provide': [674], 'sufficient': [676], 'source': [677], 'continuing': [679], 'formation,': [683], 'maintain': [685], 'vasoconstriction,': [686], 'antinatriuresis,': [687], 'hypertension.20–22': [689], 'precise': [691], 'role': [692, 1138, 1248, 1543], 'counter-regulatory': [698, 1247], 'receptor': [699, 877, 901, 938, 980, 1008, 1096, 1112, 1120, 1143, 1196, 1278, 1456], 'modulating': [701], 'responses': [704], 'currently': [706], 'unknown': [707], 'area': [713], 'future': [715], 'investigation.We': [716], 'anticipate': [717], 'might': [721], 'applied': [723], 'conditions': [726], 'retention': [729, 755], 'congestive': [732], 'heart': [733], 'failure': [734], 'Our': [737], 'observations': [738], 'suggest': [739], 'chronic': [741], 'administration': [743], 'Compound': [745, 1046], '21,': [746, 1047], 'potent,': [748], 'nonpeptide': [750], 'agonist,': [752, 1045], 'counteracts': [753], 'infusion': [764], 'hypertension': [768, 1148, 1384, 1559], 'rats.1': [770], 'Because': [771], 'no': [774], 'available': [775, 805], 'diuretic': [776], 'clinical': [778], 'use': [779], 'humans': [781], 'effectively': [783], 'reduces': [784], 'reabsorption': [786], 'at': [787], 'tubule,': [790, 816], 'it': [791], 'possible': [793], 'segment': [800], 'would': [801], 'complement': [802], 'diuretic/natriuretic': [806], 'agents': [807], 'acting': [808], 'ascending': [811], 'limb': [812], 'Henle,': [814], 'collecting': [818, 1424, 1458], 'duct.': [819], 'exciting': [821], 'possibility': [822], 'study.Brand': [825], 'KempNancy': [827], 'HowellDivision': [829], 'MetabolismDepartment': [833, 857], 'MedicineUniversity': [835, 859], 'SystemCharlottesvilleJohn': [839], 'GildeaDepartment': [841], 'PathologyUniversity': [843], 'SystemCharlottesvilleSusanna': [847], 'KellerShetal': [849], 'PadiaRobert': [851], 'CareyDivision': [853], 'SystemCharlottesvilleDisclosuresNone.References1.': [863], 'BA,': [865, 1261, 1288, 1317], 'NL,': [867, 923, 951, 1263, 1290, 1323], 'JJ,': [869, 1267, 1448], 'SR,': [871, 1265], 'SH,': [873, 1241, 1259, 1286, 1329], 'RM.': [875, 929, 1136, 1160, 1192, 1243, 1269, 1296, 1331], 'pressure.Circ': [884], 'Res.': [885], '2014;': [886], '115:388–399.LinkGoogle': [887], 'Scholar2.': [888], 'Tsutsumi': [889], 'Y,': [890, 1107, 1413], 'Matsubara': [891], 'H,': [892, 894, 1211, 1350, 1367, 1395, 1411], 'Masaki': [893], 'et': [895], 'al.': [896], 'Angiotensin': [897, 956, 1193, 1498, 1627], 'type': [899, 936, 957, 1194, 1276, 1343], '2': [900, 937, 958, 1195, 1277, 1344], 'overexpression': [902], 'activates': [903], 'vascular': [905, 1099], 'kinin': [906], 'causes': [909], 'vasodilation.J': [910], 'Clin': [911], 'Invest.': [912], '1999;': [913, 1150, 1183], '104:925–935.CrossrefMedlineGoogle': [914], 'Scholar3.': [915], 'Moore': [916], 'AF,': [917, 1213], 'Heiderstadt': [918], 'NT,': [919], 'Huang': [920], 'E,': [921, 1215], 'Wang': [924], 'ZQ,': [925], 'Siragy': [926, 954, 1133, 1153, 1186], 'HM,': [927, 1134, 1154, 1187], 'Selective': [930], 'increases': [939, 1114], 'conscious': [943, 983, 1011, 1052, 1201], 'rats.Hypertension.': [944, 965, 1202, 1312], '2001;': [945, 966, 1363], '37:1285–1291.LinkGoogle': [946], 'Scholar4.': [947], 'RM,': [949], 'Jin': [952], 'XH,': [953], 'HM.': [955], 'receptor-mediated': [959, 974, 1309, 1421], 'hypotension': [960, 1199], 'type-1': [963], 'receptor-blocked': [964], '38:1272–1277.LinkGoogle': [967], 'Scholar5.': [968], 'Li': [969, 1520], 'XC,': [970], 'Widdop': [971, 994, 1033, 1084], 'RE.': [972, 995, 1085], 'vasodilatation': [975], 'unmasked': [977], 'AT1': [979, 1007, 1119, 1420], 'blockade': [981], 'SHR.Br': [984], 'J': [985, 1017, 1056, 1432, 1472, 1531, 1534], 'Pharmacol.': [986, 1057], '2004;': [987], '142:821–830.CrossrefMedlineGoogle': [988], 'Scholar6.': [989], 'Duke': [990], 'LM,': [991, 1352], 'Evans': [992], 'RG,': [993], 'acute': [1000], 'pressure-lowering': [1002], 'vasodilator': [1004], 'antagonism': [1009], 'normotensive': [1012], 'hypertensive': [1015, 1054, 1430], 'rats.Am': [1016, 1431], 'Physiol': [1018, 1433, 1473], 'Heart': [1019, 1614], 'Circ': [1020], 'Physiol.': [1021, 1435, 1475], '2005;': [1022, 1436], '288:H2289–H2297.CrossrefMedlineGoogle': [1023], 'Scholar7.': [1024], 'Bosnyak': [1025, 1070], 'S,': [1026, 1071, 1077], 'Welungoda': [1027, 1072], 'IK,': [1028], 'Hallberg': [1029], 'A,': [1030, 1415, 1490, 1573], 'Alterman': [1031], 'M,': [1032, 1190, 1219, 1369, 1571], 'RE,': [1034], 'Jones': [1035, 1061], 'ES.': [1036], 'Stimulation': [1037], 'non-peptide': [1044], 'evokes': [1048], 'vasodepressor': [1049], 'spontaneously': [1053], 'rats.Br': [1055], '2010;': [1058], '159:709–716.CrossrefMedlineGoogle': [1059], 'Scholar8.': [1060], 'ES,': [1062], 'Del': [1063], 'Borgo': [1064], 'MP,': [1065], 'Kirsch': [1066], 'JF,': [1067, 1319], 'Clayton': [1068], 'D,': [1069, 1417, 1529], 'I,': [1073], 'Hausler': [1074], 'N,': [1075], 'Unabia': [1076], 'Perlmutter': [1078], 'P,': [1079], 'Thomas': [1080], 'WG,': [1081], 'Aguilar': [1082], 'MI,': [1083], 'A': [1086], 'single': [1087], 'beta-amino': [1088], 'acid': [1089], 'substitution': [1090], 'confers': [1094], 'selectivity': [1097], 'function.Hypertension.': [1100], '2011;': [1101, 1405, 1476], '57:570–576.LinkGoogle': [1102], 'Scholar9.': [1103], 'Ali': [1104], 'Q,': [1105], 'Wu': [1106], 'Hussain': [1108], 'T.': [1109], 'Chronic': [1110], 'ACE2': [1116], 'activity,': [1117], 'attenuates': [1118], 'obese': [1126], 'Zucker': [1127], 'rats.Kidney': [1128], 'Int.': [1129, 1236], '2013;': [1130, 1255], '84:931–939.CrossrefMedlineGoogle': [1131], 'Scholar10.': [1132], 'Protective': [1137], 'wrap': [1147], 'model.Hypertension.': [1149], '33:1237–1242.CrossrefMedlineGoogle': [1151], 'Scholar11.': [1152], 'Inagami': [1155, 1220], 'T,': [1156, 1158, 1217, 1221], 'Ichiki': [1157], 'Sustained': [1161], 'hypersensitivity': [1162], 'its': [1167], 'mice': [1170, 1231], 'lacking': [1171, 1232], 'subtype-2': [1173], '(AT2)': [1174], 'receptor.Proc': [1176], 'Natl': [1177], 'Acad': [1178], 'Sci': [1179], 'U': [1180], 'S': [1181], '96:6506–6510.CrossrefMedlineGoogle': [1184], 'Scholar12.': [1185], 'de': [1188, 1488], 'Gasparo': [1189], 'mediates': [1197], 'valsartan-induced': [1198], '2000;': [1203, 1237], '35:1074–1077.LinkGoogle': [1204], 'Scholar13.': [1205], 'Gross': [1206], 'V,': [1207], 'Schunck': [1208], 'WH,': [1209], 'Honeck': [1210], 'Milia': [1212], 'Kärgel': [1214], 'Walther': [1216], 'Bader': [1218], 'Schneider': [1222], 'W,': [1223, 1325], 'Luft': [1224], 'FC.': [1225], 'Inhibition': [1226], 'receptor.Kidney': [1235], '57:191–202.CrossrefMedlineGoogle': [1238], 'Scholar14.': [1239], 'receptors:': [1245], 'beneficial': [1246], 'cardiovascular': [1250], 'function.Pflugers': [1253], 'Arch.': [1254], '120:476–479.Google': [1256], 'Scholar15.': [1257], 'Mechanisms': [1270], 'dopamine': [1272], 'D(1)': [1273], 'interaction': [1279], 'natriuresis.Hypertension.': [1281], '2012;': [1282, 1346], '59:437–445.LinkGoogle': [1283], 'Scholar16.': [1284], 'Fournie-Zaluski': [1291], 'MC,': [1292, 1397, 1409, 1440], 'Roques': [1293], 'BP,': [1294], 'Conversion': [1297], 'critical': [1306], '2008;': [1313], '51:460–465.LinkGoogle': [1314], 'Scholar17.': [1315], 'Bell': [1318], 'Rottkamp': [1320], 'DM,': [1321], 'Shao': [1324], 'Navar': [1326, 1353, 1370, 1392, 1418], 'LG,': [1327, 1371, 1393], 'Intrarenal': [1332], 'predominant': [1337], 'receptors.Hypertension.': [1345], '60:387–395.LinkGoogle': [1347], 'Scholar18.': [1348], 'Kobori': [1349, 1366, 1394, 1410], 'Harrison-Bernard': [1351], 'LG.': [1354, 1419], 'Enhancement': [1355, 1451], 'angiotensinogen': [1357], 'expression': [1358], 'II-dependent': [1361, 1429], 'hypertension.Hypertension.': [1362, 1404], '37:1329–1335.LinkGoogle': [1364], 'Scholar19.': [1365], 'Nangaku': [1368], 'Nishiyama': [1372], 'renin-angiotensin': [1376, 1401], 'system:': [1377], 'physiology': [1379], 'pathobiology': [1382], 'kidney': [1386], 'disease.Pharmacol': [1387], 'Rev.': [1388], '2007;': [1389], '59:251–287.CrossrefMedlineGoogle': [1390], 'Scholar20.': [1391], 'Prieto': [1396, 1439], 'Gonzalez-Villalobos': [1398], 'RA.': [1399], 'Intratubular': [1400], '57:355–362.LinkGoogle': [1406], 'Scholar21.': [1407], 'Prieto-Carrasquero': [1408], 'Ozawa': [1412], 'Gutiérrez': [1414], 'Seth': [1416], 'enhancement': [1422], 'duct': [1425, 1459], 'Renal': [1434, 1474], '289:F632–F637.CrossrefMedlineGoogle': [1437], 'Scholar22.': [1438], 'Williams': [1441], 'DE,': [1442], 'Liu': [1443], 'L,': [1444], 'Kavanagh': [1445], 'KL,': [1446], 'Mullins': [1447], 'Mitchell': [1449], 'KD.': [1450], 'prorenin': [1455], 'Cyp1a1-Ren2': [1461], 'rats': [1462], 'development': [1466], 'progression': [1468], 'malignant': [1470], 'hypertension.Am': [1471], '300:F581–F588.CrossrefMedlineGoogle': [1477], 'Scholar': [1478], 'Previous': [1479], 'Back': [1480], 'top': [1482], 'Next': [1483], 'FiguresReferencesRelatedDetailsCited': [1484], 'By': [1485], 'Elsaafien': [1486], 'K,': [1487], 'Kloet': [1489], 'Krause': [1491], 'E': [1492], 'Sumners': [1494], 'C': [1495], '(2020)': [1496], 'Brain': [1497], 'Type-1': [1499], 'Type-2': [1501], 'Receptors': [1502], 'Physiological': [1504, 1561], 'Hypertensive': [1506], 'Conditions:': [1507], 'Focus': [1508], 'on': [1509], 'Neuroinflammation,': [1510], 'Current': [1511], 'Hypertension': [1512], 'Reports,': [1513], '10.1007/s11906-020-01062-0,': [1514], '22:7,': [1515], 'Online': [1516, 1566, 1598], 'publication': [1517, 1567, 1599], 'date:': [1518, 1568, 1600], '1-Jul-2020.': [1519], 'X,': [1521, 1523, 1525], 'Zheng': [1522], 'Chen': [1524], 'Zhao': [1526], 'C,': [1527], 'Zhu': [1528], 'Zhang': [1530], 'Zhuo': [1533], '(2019)': [1535], 'Genetic': [1536], 'genomic': [1538], 'Na': [1546], '+': [1547, 1549], '/H': [1548], 'exchanger': [1550], '3': [1551], 'II-induced': [1558], 'Genomics,': [1562], '10.1152/physiolgenomics.00122.2018,': [1563], '51:4,': [1564], '(97-108),': [1565], '1-Apr-2019.': [1569], 'Gironacci': [1570], 'Vicario': [1572], 'Cerezo': [1574], 'G': [1575], 'Silva': [1577], 'M': [1578], '(2018)': [1579], 'axis': [1582], 'brain': [1588], 'disorders:': [1589], 'translational': [1591], 'approach,': [1592], 'Clinical': [1593], 'Science,': [1594], '10.1042/CS20180189,': [1595], '132:10,': [1596], '(1021-1038),': [1597], '31-May-2018.': [1601], 'October': [1602], '10,': [1603, 1620], '2014Vol': [1604], 'Issue': [1606], '9': [1607], 'Advertisement': [1608, 1624], 'Article': [1609], 'InformationMetrics': [1610], '©': [1611], '2014': [1612, 1621], 'American': [1613], 'Association,': [1615], 'Inc.https://doi.org/10.1161/CIRCRESAHA.114.304975PMID:': [1616], '25301825': [1617], 'publishedOctober': [1619], 'PDF': [1622], 'download': [1623], 'SubjectsACE/Angiotensin': [1625], 'Receptors/Renin': [1626], 'System': [1628]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2009926509', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-08T05:57:42.553790', 'created_date': '2016-06-24'}