Critical Regions for Activation Gating of the Inositol 1,4,5-Trisphosphate Receptor

Name: Work Video:
Duration: 3 min 30 s
Keiko Uchida; Hiroshi Miyauchi; Teiichi Furuichi; Takayuki Michikawa; Katsuhiko Mikoshiba
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2127, 2214, 2266, 3492, 4306], 'understand': [1, 204, 1946], 'the': [2, 9, 18, 26, 38, 49, 70, 78, 87, 107, 114, 151, 183, 195, 205, 212, 221, 229, 241, 252, 273, 281, 290, 310, 317, 354, 386, 398, 439, 447, 467, 477, 483, 513, 521, 683, 687, 691, 707, 711, 825, 831, 840, 843, 908, 912, 973, 978, 987, 1009, 1174, 1192, 1336, 1363, 1368, 1385, 1390, 1399, 1403, 1415, 1487, 1490, 1529, 1538, 1544, 1630, 1633, 1636, 1640, 1644, 1717, 1725, 1732, 1739, 1763, 1798, 1813, 1873, 1883, 1890, 1925, 1930, 1940, 1947, 1951, 1955, 2021, 2025, 2124, 2170, 2299, 2323, 2330, 2333, 2371, 2410, 2420, 2448, 2585, 2663, 2841, 3010, 3020, 3035, 3128, 3133, 3161, 3165, 3173, 3194, 3311, 3326, 3370, 3452, 3458, 3466, 3470, 3499, 3518, 3525, 3579, 3604, 3666, 3721, 3726, 3735, 3739, 3748, 3800, 4007, 4049, 4055, 4061, 4073, 4086, 4101, 4107, 4136, 4162, 4308, 4313, 4318, 4330, 4333, 4352, 4383, 4387, 4396, 4404, 4413, 4426], 'molecular': [3, 206, 1645, 1948, 3589, 3647], 'mechanism': [4, 207, 1646, 2023], 'of': [5, 8, 21, 31, 48, 111, 124, 194, 198, 208, 211, 224, 234, 251, 314, 327, 397, 401, 428, 438, 469, 538, 574, 638, 713, 972, 986, 993, 1011, 1093, 1201, 1338, 1367, 1402, 1418, 1489, 1514, 1632, 1647, 1711, 1714, 1719, 1728, 1734, 1741, 1801, 1812, 1876, 1882, 1939, 1950, 1954, 1961, 1968, 2011, 2024, 2029, 2061, 2138, 2188, 2264, 2284, 2332, 2370, 2584, 2805, 2864, 2893, 2987, 3037, 3085, 3098, 3135, 3158, 3167, 3175, 3189, 3196, 3270, 3313, 3328, 3332, 3440, 3524, 3545, 3578, 3606, 3656, 3665, 3738, 3755, 3782, 3795, 3913, 3921, 4060, 4088, 4100, 4109, 4112, 4130, 4154, 4161, 4312, 4332, 4354, 4371, 4386, 4398, 4401, 4408, 4415, 4438], 'ligand-induced': [6, 209, 1952], 'gating': [7, 210, 1401, 1953, 2010, 2022], 'inositol': [10, 213, 406], '1,4,5-trisphosphate': [11, 214, 407, 417], '(IP3)': [12, 215], 'receptor': [13, 42, 216, 245, 413, 485, 989, 1404, 1491, 4057], '(IP3R)/Ca2+release': [14, 217], 'channel,': [15, 218, 997], 'we': [16, 44, 164, 219, 247, 367, 1957, 3434, 3446, 3480, 3497, 3602, 3733, 4118], 'analyzed': [17, 220, 1958, 3356], 'channel': [19, 158, 222, 361, 1349, 1353, 1545, 1601, 1641, 3476], 'properties': [20, 223, 3754, 4160], 'deletion': [22, 225, 1190, 1963, 2058, 3438, 3668, 3758, 4163], 'mutants': [23, 71, 90, 100, 226, 274, 293, 303, 1964, 1967, 2589, 3439, 3483], 'retaining': [24, 227], 'both': [25, 173, 228, 376, 598, 2279, 3451], 'IP3-binding': [27, 230, 1022, 1051, 1175, 1202, 1530, 3453, 3663, 3718, 3753, 3776, 3919], 'and': [28, 59, 75, 94, 104, 129, 175, 231, 262, 278, 297, 307, 332, 378, 506, 578, 594, 600, 690, 820, 914, 1120, 1521, 1600, 1639, 1643, 1667, 1731, 1936, 1965, 2002, 2070, 2164, 2282, 2314, 2454, 2505, 2519, 2561, 2587, 2620, 2715, 2730, 2749, 2820, 2840, 2880, 2926, 2998, 3019, 3073, 3080, 3100, 3202, 3210, 3272, 3294, 3320, 3354, 3367, 3369, 3457, 3475, 3487, 3505, 3757, 3819, 3877, 3905, 3926, 3933, 4048, 4058, 4078, 4116, 4125, 4143, 4149, 4406], 'channel-forming': [29, 116, 232, 319], 'domains': [30, 178, 233, 381, 647], 'IP3R1.': [32, 235, 2012, 3442], 'Using': [33, 236, 3106], 'intrinsically': [34, 237, 1973], 'IP3R-deficient': [35, 238, 1974], 'cells': [36, 40, 239, 243, 1666, 1976, 2462, 2523, 3275, 3504, 3674, 3728, 3770, 3825, 3847, 3879, 4069, 4349, 4363, 4366, 4424], 'as': [37, 154, 188, 240, 357, 391, 476, 516, 597, 1182, 2169, 2207, 2406, 2526, 2627, 2939, 3237, 3682, 3965, 4133, 4270, 4299, 4364], 'host': [39, 242, 4365], 'for': [41, 133, 157, 244, 336, 360, 706, 1008, 1057, 1128, 1185, 1352, 1492, 1889, 1919, 2008, 2212, 2269, 2303, 2307, 2311, 2316, 2665, 2773, 2791, 2837, 2849, 3002, 3208, 3303, 3343, 3469, 3940, 3951, 3968, 4054, 4141, 4367], 'expression,': [43, 246], 'determined': [45, 248], 'that': [46, 84, 121, 191, 249, 287, 324, 394, 423, 519, 824, 985, 999, 1581, 1872, 1929, 1997, 3652, 3912, 3961, 4003, 4085, 4360, 4419, 4430], 'six': [47, 250, 697], 'mutants,': [50, 253, 3445], 'those': [51, 254, 3794], 'lacking': [52, 72, 91, 101, 255, 275, 294, 304, 3484], 'residues': [53, 73, 92, 102, 127, 256, 276, 295, 305, 330, 1091, 3485, 3543, 3962], '1–223,': [54, 257], '651–1130,': [55, 105, 130, 258, 308, 333], '1267–2110,': [56, 259], '1845–2042,': [57, 260], '1845–2216,': [58, 261], '2610–2748,': [60, 263], 'did': [61, 264], 'not': [62, 85, 265, 288, 1805, 1916, 3596, 3730, 4010], 'exhibit': [63, 266], 'any': [64, 267, 1484, 2908], 'measurable': [65, 268], 'Ca2+': [66, 269, 410, 470, 490, 529, 533, 995, 1012, 1720, 1736, 1764, 1802, 1824, 1877, 1895, 1899, 1942, 2865, 2897, 2911, 3050, 3129, 3150, 3154, 4309, 4334, 4339, 4373, 4388, 4409, 4428], 'release': [67, 270, 411, 468, 487, 491, 534, 996, 1727, 1765, 1803, 1875, 1896, 1932, 1943, 2866, 2898, 3051, 4310, 4340, 4374, 4389, 4410, 4429], 'activity,': [68, 271, 1579], 'whereas': [69, 272], '1131–1379': [74, 93, 277, 296], '2736–2749': [76, 279], 'retained': [77, 106, 280, 309], 'activity.': [79, 282], 'Limited': [80, 283, 3232], 'trypsin': [81, 284, 3233, 3281, 3317], 'digestion': [82, 285, 3234], 'showed': [83, 286, 3771, 4084], 'only': [86, 289], 'IP3-gated': [88, 291, 531], 'Ca2+-permeable': [89, 292], '2736–2749,': [95, 298, 3488], 'but': [96, 299, 1914], 'also': [97, 137, 300, 340], 'two': [98, 122, 301, 325, 1001, 1341, 2000, 3482, 4120], 'nonfunctional': [99, 302], '1–223': [103, 128, 306, 331, 3486, 3963], 'normal': [108, 311], 'folding': [109, 312], 'structure': [110, 169, 313, 372, 637, 1007], 'at': [112, 144, 315, 347, 570, 1339, 1998, 2123, 2135, 2204, 2271, 2278, 2447, 2509, 2762, 2769, 2776, 2783, 2794, 2833, 2845, 2852, 2928, 3005, 3082, 3092, 3124, 3300, 3340], 'least': [113, 316, 571, 1340, 1999], 'C-terminal': [115, 152, 184, 318, 355, 387, 692, 826, 1386, 1416, 1540], 'domain.': [117, 320], 'These': [118, 321, 2013, 2402], 'results': [119, 322, 1197, 3519], 'indicate': [120, 323], 'regions': [123, 326, 834, 917, 2001, 3468], 'IP3R1,': [125, 328, 2063, 2286], 'viz.': [126, 329], 'are': [131, 334, 536, 569, 1171, 1532, 2006, 3761, 4268, 4297], 'critical': [132, 335, 3467], 'IP3-induced': [134, 337, 409, 489, 1400], 'gating.': [135, 338], 'We': [136, 339, 1995], 'identified': [138, 341], 'a': [139, 166, 189, 342, 369, 392, 420, 517, 714, 836, 1005, 1018, 1053, 1183, 1260, 1345, 1358, 1585, 1661, 1822, 1934, 1959, 2003, 2185, 2208, 2261, 2292, 2757, 2787, 2890, 3025, 3083, 3107, 3140, 3645, 3772, 3779, 3957, 3966, 4293], 'highly': [140, 343, 982], 'conserved': [141, 344], 'cysteine': [142, 345, 2004, 2270], 'residue': [143, 346, 2005, 2203], 'position': [145, 348, 2205, 2272], '2613,': [146, 349], 'which': [147, 172, 186, 350, 375, 389, 695, 1170, 1527, 1542, 1892, 2197], 'is': [148, 351, 419, 424, 704, 822, 981, 1259, 1350, 1393, 1412, 1804, 1878, 1933, 3791, 4009, 4431], 'located': [149, 352, 906, 1413], 'within': [150, 353, 1584, 3542], 'tail,': [153, 185, 356, 388], 'being': [155, 358], 'essential': [156, 359, 1055, 1124, 2007], 'opening.': [159, 362, 1354, 3477], 'Based': [160, 363], 'on': [161, 364, 446, 1480, 1924, 4412], 'these': [162, 365, 1000, 3444, 3494, 3530], 'results,': [163, 366], 'propose': [165, 368], 'novel': [167, 370], 'five-domain': [168, 371], 'model': [170, 373], 'in': [171, 374, 431, 450, 710, 839, 907, 1198, 1362, 1398, 1414, 1486, 1660, 1664, 1716, 1777, 1972, 2483, 2512, 2565, 2572, 2603, 2660, 2717, 2756, 2786, 2801, 2860, 2923, 2984, 3014, 3034, 3049, 3282, 3636, 3659, 3672, 3720, 3763, 3768, 3799, 3823, 4067, 4092, 4106, 4135, 4292, 4329, 4422], 'N-terminal': [174, 377, 684, 1167, 1193, 1364, 1524], 'internal': [176, 379, 1962, 2328, 3437, 3667], 'coupling': [177, 380, 1596, 1649, 3471], 'transduce': [179, 382], 'ligand-binding': [180, 383, 685, 3736], 'signals': [181, 384, 3113], 'to': [182, 385, 433, 482, 904, 977, 984, 1173, 1180, 1344, 1395, 1651, 1658, 1724, 1807, 2184, 2199, 2260, 2329, 2889, 2906, 3147, 3182, 3464, 3793, 3911, 4006, 4433], 'acts': [187, 390], 'gatekeeper': [190, 393], 'triggers': [192, 395], 'opening': [193, 396, 1602], 'activation': [196, 399, 434], 'gate': [197, 400], 'IP3R1': [199, 402, 1095, 1420, 1516, 1970, 2032, 2140, 2335, 2373, 3546, 3766, 3797, 3821, 3915, 4132, 4394, 4420, 4440], 'following': [200, 403, 830, 1389, 3164, 4137], 'IP3': [201, 404, 465, 484, 1059, 1129, 1186, 1342, 1355, 1493, 1598, 1715, 1742, 2934, 3041, 3190, 3941, 3952, 3969, 4004, 4079, 4416], 'binding.': [202, 405], 'IP3receptor': [408], 'ryanodine': [412, 988], 'monoclonal': [414, 1406], 'antibody': [415, 1407, 3372, 3537, 3600], 'Inositol': [416], '(IP3)1': [418], 'second': [421], 'messenger': [422], 'produced': [425], 'by': [426, 435, 480, 524, 1773, 2141, 2458, 2524, 2548, 2592, 2669, 2707, 2753, 3132, 3310, 3351, 3357, 3510, 3599, 3608, 3677, 4187, 4196, 4204, 4221, 4238, 4249, 4280, 4286, 4376, 4391], 'hydrolysis': [427], 'phosphatidylinositol': [429], '4,5-bisphosphate': [430], 'response': [432], 'extracellular': [436, 525], 'stimuli': [437, 526], 'G': [440], 'protein-': [441], 'or': [442, 1535, 1810, 2275, 2277, 2412, 2547, 2921], 'tyrosine': [443], 'kinase-coupled': [444], 'receptors': [445, 3581, 3670, 3901, 3923, 4063], 'plasma': [448, 1926], 'membrane': [449, 2915, 2972, 3045, 3162, 3526, 3722, 3744, 4319, 4344], 'various': [451, 3187, 4399], 'cell': [452, 499, 2600, 3508, 3532, 3750, 4094, 4122, 4325], 'types': [453, 573], '(1Berridge': [454], 'M.J.': [455], 'Nature.': [456, 1111, 1157, 1433, 1862, 2351, 2389, 4477], '1993;': [457, 1906], '361:': [458], '315-325Crossref': [459], 'PubMed': [460, 565, 589, 631, 657, 678, 741, 765, 791, 815, 869, 892, 943, 964, 1047, 1084, 1115, 1161, 1227, 1253, 1274, 1302, 1330, 1379, 1437, 1455, 1471, 1505, 1568, 1624, 1687, 1704, 1757, 1793, 1849, 1866, 1909, 1990, 2050, 2096, 2118, 2253, 2355, 2393, 2442, 2476, 2542, 2651, 2696, 2966, 3227, 3261, 3397, 3429, 3574, 3629, 3709, 3814, 3841, 3872, 3895, 3994, 4023, 4045, 4464, 4481], 'Scopus': [461, 590, 632, 658, 679, 742, 766, 792, 816, 870, 893, 965, 1085, 1116, 1162, 1228, 1254, 1275, 1303, 1331, 1380, 1438, 1456, 1472, 1506, 1569, 1625, 1705, 1758, 1794, 1850, 1867, 1910, 1991, 2051, 2097, 2119, 2254, 2356, 2394, 2443, 2477, 2543, 2652, 2697, 2967, 3228, 3262, 3398, 3430, 3630, 3710, 3815, 3842, 3873, 3896, 3995, 4024, 4465, 4482], '(6280)': [462], 'Google': [463, 566, 592, 634, 660, 681, 744, 768, 794, 818, 872, 895, 944, 967, 1048, 1087, 1118, 1164, 1230, 1256, 1277, 1305, 1333, 1382, 1440, 1458, 1474, 1508, 1571, 1627, 1688, 1707, 1760, 1796, 1852, 1869, 1912, 1993, 2053, 2099, 2121, 2256, 2358, 2396, 2445, 2479, 2545, 2654, 2699, 2969, 3230, 3264, 3400, 3432, 3575, 3632, 3712, 3817, 3844, 3875, 3898, 3997, 4026, 4046, 4467, 4484], 'Scholar).': [464, 567, 635, 896, 968, 1049, 1165, 1257, 1383, 1509, 1572, 1628, 1708, 1761, 1994, 2655, 2970, 3231, 3265, 3401, 3576, 3633, 3713, 3899, 3998, 4485], 'mediates': [466, 1893], 'from': [471, 1191, 1897, 2177, 2220, 2322, 2337, 2375, 3160, 3520, 3529, 3725, 3747, 4317, 4322, 4343, 4347], 'intracellular': [472, 528, 532, 994, 1898, 1941], 'storage': [473], 'sites': [474, 1631], 'such': [475], 'endoplasmic': [478, 1669], 'reticulum': [479, 1670], 'binding': [481, 1060, 1130, 1187, 1337, 1356, 1599, 2935, 2988, 3031, 3474, 3680, 3908, 3970, 4005, 4080], '(IP3R)/Ca2+': [486], 'channel.': [488], '(IICR)': [492], 'regulates': [493], 'numerous': [494], 'physiological': [495], 'processes,': [496], 'including': [497], 'fertilization,': [498], 'proliferation,': [500], 'development,': [501], 'muscle': [502], 'contraction,': [503], 'secretion,': [504], 'learning,': [505], 'memory.': [507], 'In': [508, 3478], 'this': [509], 'signal': [510, 3643], 'transduction': [511], 'pathway,': [512], 'IP3R': [514, 540, 1015, 1348, 1369, 1575, 2586, 3742, 4008, 4089], 'works': [515], 'switch': [518], 'converts': [520], 'information': [522], 'carried': [523], 'into': [527, 644, 1517, 1818, 2020, 2103, 2362, 2400, 2418, 2425, 2521, 3502], 'signals.': [530], 'channels': [535, 1002, 1923], 'composed': [537], 'four': [539, 1523], 'subunits': [541, 844, 1592], '(2Maeda': [542, 1024], 'N.': [543, 549, 1025, 1031, 1108, 1430, 1443, 1463, 1497, 2040, 2348, 2386, 2432, 3617, 3804, 3831, 4013], 'Kawasaki': [544, 1026], 'T.': [545, 551, 581, 603, 607, 613, 615, 649, 720, 726, 728, 781, 783, 848, 854, 856, 919, 929, 1027, 1033, 1066, 1068, 1070, 1100, 1148, 1152, 1209, 1211, 1213, 1235, 1241, 1243, 1265, 1267, 1282, 1286, 1308, 1318, 1422, 1552, 1554, 1608, 1610, 1691, 1744, 1780, 1829, 1833, 1984, 2038, 2075, 2081, 2083, 2112, 2152, 2158, 2160, 2162, 2233, 2237, 2340, 2378, 2430, 2470, 2536, 2557, 2559, 2635, 2637, 2674, 2684, 2945, 2951, 2953, 3245, 3247, 3381, 3383, 3408, 3414, 3416, 3550, 3560, 3688, 3694, 3696, 3829, 3851, 3857, 3859, 3885, 3887, 3976, 3978, 3980, 4444, 4448], 'Nakade': [546, 1028], 'S.': [547, 724, 736, 751, 852, 864, 1029, 1102, 1140, 1312, 1424, 1461, 1495, 1673, 1699, 1752, 1788, 1902, 2079, 2091, 2227, 2342, 2380, 2678, 2949, 2961, 3412, 3424, 3692, 3704, 3855, 3867, 4029], 'Yokota': [548, 1030], 'Taguchi': [550, 1032], 'Kasai': [552, 1034], 'M.': [553, 611, 617, 1035, 1064, 1150, 1156, 1207, 1314, 1316, 1445, 1904, 1980, 1982, 2108, 2110, 2150, 2154, 2239, 2466, 2468, 2532, 2534, 2680, 2682, 3215, 3619, 3806, 3974, 4015], 'Mikoshiba': [554, 582, 618, 650, 729, 784, 857, 932, 1036, 1071, 1109, 1153, 1214, 1244, 1289, 1319, 1431, 1448, 1464, 1498, 1555, 1611, 1836, 2041, 2084, 2240, 2349, 2387, 2433, 2638, 2685, 2954, 3248, 3384, 3417, 3563, 3622, 3697, 3807, 3832, 3860, 3888, 3981, 4016, 4451], 'K.': [555, 583, 619, 651, 730, 785, 858, 933, 1037, 1072, 1106, 1110, 1154, 1215, 1245, 1290, 1320, 1428, 1432, 1447, 1449, 1465, 1499, 1556, 1612, 1837, 2042, 2085, 2156, 2165, 2241, 2346, 2350, 2384, 2388, 2434, 2555, 2562, 2639, 2686, 2955, 3249, 3385, 3418, 3564, 3621, 3623, 3698, 3808, 3833, 3861, 3889, 3982, 4017, 4452], 'J.': [556, 584, 620, 652, 674, 754, 787, 804, 881, 934, 955, 1038, 1073, 1138, 1216, 1280, 1291, 1310, 1375, 1450, 1467, 1501, 1557, 1613, 1678, 1827, 1838, 1986, 2114, 2242, 2472, 2538, 2640, 2676, 3218, 3250, 3386, 3565, 3624, 3810, 3891, 3983, 4019, 4036, 4442, 4453, 4498], 'Biol.': [557, 621, 755, 805, 882, 935, 1039, 1074, 1217, 1292, 1558, 1614, 1679, 1839, 2243, 2641, 3219, 3251, 3387, 3566, 3984, 4037, 4454], 'Chem.': [558, 622, 756, 806, 883, 936, 1040, 1075, 1218, 1293, 1559, 1615, 1680, 1840, 2244, 2642, 3220, 3252, 3388, 3567, 3985, 4038, 4455], '1991;': [559, 675, 738, 866, 1041, 1468, 1502, 2093, 2963, 3426, 3706, 3869], '266:': [560, 1042], '1109-1116Abstract': [561, 1043], 'Full': [562, 626, 628, 760, 762, 810, 812, 887, 889, 940, 959, 961, 1044, 1079, 1081, 1222, 1224, 1297, 1299, 1325, 1327, 1563, 1565, 1619, 1621, 1684, 1844, 1846, 2047, 2248, 2250, 2439, 2646, 2648, 2691, 2693, 3224, 3256, 3258, 3392, 3394, 3571, 3838, 3989, 3991, 4042, 4459, 4461], 'Text': [563, 627, 629, 761, 763, 811, 813, 888, 890, 941, 960, 962, 1045, 1080, 1082, 1223, 1225, 1298, 1300, 1326, 1328, 1564, 1566, 1620, 1622, 1685, 1845, 1847, 2048, 2249, 2251, 2440, 2647, 2649, 2692, 2694, 3225, 3257, 3259, 3393, 3395, 3572, 3839, 3990, 3992, 4043, 4460, 4462], 'PDF': [564, 630, 764, 814, 891, 942, 963, 1046, 1083, 1226, 1301, 1329, 1567, 1623, 1686, 1848, 2049, 2252, 2441, 2650, 2695, 3226, 3260, 3396, 3573, 3840, 3993, 4044, 4463], 'There': [568, 3714], 'three': [572, 645], 'IP3Rs': [575, 639, 1816, 3760, 4103], '(IP3R1,': [576], 'IP3R2,': [577], 'IP3R3)': [579], '(3Furuichi': [580, 648], 'Neurochem.': [585, 653, 1451, 3625], '1995;': [586, 623, 654, 1294, 1841, 4456], '64:': [587, 655], '953-960Crossref': [588, 656], '(181)': [591, 659], 'Scholar),': [593, 819, 1088, 1119, 1334, 1475, 1797, 1870, 1913, 2100, 2700, 3433, 3845, 3876, 4047], 'they': [595], 'exist': [596], 'homo-': [599], 'heterotetramers': [601], '(4Monkawa': [602], 'Miyawaki': [604, 772, 926, 1103, 1283, 1425, 1830, 2343, 2381, 3557, 3882, 4445], 'A.': [605, 718, 737, 773, 775, 779, 846, 865, 925, 927, 1104, 1284, 1426, 1700, 1753, 1789, 1831, 2036, 2073, 2092, 2229, 2344, 2382, 2428, 2943, 2962, 3406, 3425, 3556, 3558, 3686, 3705, 3827, 3849, 3868, 3883, 4446], 'Sugiyama': [606], 'Yoneshima': [608], 'H.': [609, 777, 921, 923, 1237, 1550, 1606, 1978, 2106, 2235, 2464, 2530, 2633, 3243, 3379, 3552, 3554, 3881], 'Yamamoto-Hino': [610], 'Furuichi': [612, 719, 782, 847, 928, 1069, 1147, 1212, 1242, 1285, 1317, 1553, 1609, 1832, 2037, 2074, 2429, 2636, 2683, 2944, 3246, 3382, 3407, 3559, 3687, 3828, 3850, 3886, 3979, 4447], 'Saruta': [614], 'Hasegawa': [616], '270:': [624, 1295, 1842, 4457], '14700-14704Abstract': [625], '(196)': [633], 'The': [636, 701, 969, 1050, 1166, 1573, 1709, 2190, 2319, 2365, 2765, 2779, 2797, 2829, 2855, 2914, 2933, 2971, 3044, 3156, 3306, 3346, 3662, 3752, 3918, 4098], 'has': [640, 835, 901, 1017, 1476, 1655, 1915, 4000], 'traditionally': [641], 'been': [642, 902, 1178, 1656, 1917, 4001], 'divided': [643], 'functional': [646, 1595], 'Scholar,': [661, 745, 769, 795, 945, 1231, 1278, 1306, 1441, 1459, 1689, 1853, 4027, 4468], '5Südhof': [662], 'T.C.': [663, 1373], 'Newton': [664], 'C.L.': [665], 'Archer': [666], 'III,': [667], 'B.T.': [668], 'Ushkaryov': [669], 'Y.A.': [670], 'Mignery': [671, 802, 879], 'G.A.': [672, 803, 880, 1371], 'EMBO': [673, 1374, 1985, 2113, 2471, 2537, 3809, 4018], '10:': [676], '3199-3206Crossref': [677], '(322)': [680], 'Scholar):': [682], 'domain;': [686, 689], 'modulatory/coupling': [688], 'transmembrane/channel-forming': [693], 'domain,': [694], 'contains': [696, 1122, 1543], 'putative': [698, 832, 3459], 'membrane-spanning': [699, 833], 'regions.': [700], 'transmembrane': [702, 916, 974, 1391, 3460], 'region': [703, 828, 1056, 1196, 1388, 3454], 'required': [705, 1351], 'intermolecular': [708, 1588], 'interaction': [709, 1583, 1589], 'formation': [712], 'tetrameric': [715, 1347], 'complex': [716], '(6Miyawaki': [717, 845, 2072, 2942, 3405, 3685, 3848], 'Ryou': [721, 849, 2076, 2946, 3409, 3689, 3852], 'Y.': [722, 850, 931, 2077, 2947, 3410, 3562, 3690, 3853], 'Yoshikawa': [723, 851, 1101, 1145, 1423, 2078, 2341, 2379, 2948, 3411, 3691, 3854], 'Nakagawa': [725, 853, 2080, 2950, 3413, 3693, 3856], 'Saitoh': [727, 855, 2082, 2952, 3415, 3695, 3858], 'Proc.': [731, 859, 1694, 1747, 1783, 2086, 2956, 3419, 3699, 3862], 'Natl.': [732, 860, 1695, 1748, 1784, 2087, 2957, 3420, 3700, 3863], 'Acad.': [733, 861, 1696, 1749, 1785, 2088, 2958, 3421, 3701, 3864], 'Sci.': [734, 862, 1697, 1750, 1786, 2089, 2959, 3422, 3702, 3865], 'U.': [735, 863, 1698, 1751, 1787, 2090, 2960, 3423, 3703, 3866], '88:': [739, 867, 2094, 2964, 3427, 3707, 3870], '4911-4915Crossref': [740, 868, 2095, 2965, 3428, 3708, 3871], '(135)': [743, 871, 1457, 1706, 1759, 1795, 2098, 2968, 3431, 3631, 3711, 3874], '7Joseph': [746], 'S.K.': [747, 949, 4492], 'Boehning': [748], 'D.': [749, 947, 4490], 'Pierson': [750], 'Nicchitta': [752], 'C.V.': [753], '1997;': [757, 788, 1987, 2115, 2473, 2539, 3892], '272:': [758], '1579-1588Abstract': [759], '(59)': [767], '8Sayers': [770], 'L.G.': [771], 'Muto': [774], 'Takeshita': [776], 'Yamamoto': [778, 924, 3555], 'Michikawa': [780, 1067, 1151, 1210, 1281, 1551, 1607, 1828, 2634, 2670, 3244, 3380, 3884, 3977, 4443], 'Biochem.': [786, 1246, 1466, 1500, 3890], '323:': [789], '273-280Crossref': [790], '(47)': [793], '9Galvan': [796], 'D.L.': [797, 874], 'Borrego-Diaz': [798, 875], 'E.': [799, 876], 'Perez': [800, 877], 'P.J.': [801, 878], '1999;': [807, 884, 1250, 1322, 1560, 1616, 2643, 2688, 3253, 3389], '274:': [808, 885, 1561, 1617, 2644, 3254, 3390], '29483-29492Abstract': [809, 886], '(77)': [817, 894], 'it': [821, 1121, 1769], 'likely': [823], 'cytoplasmic': [827, 1365, 1387, 1525, 1637], 'just': [829], 'supportive': [837], 'role': [838], 'association': [841], 'among': [842, 1090], 'Scholar,9Galvan': [873], 'An': [897, 2173], 'ion': [898, 1922], 'conduction': [899, 1010], 'pore': [900], 'proposed': [903], 'be': [905, 1396, 1652, 1771, 4434], 'hydrophobic': [909], 'segment': [910, 980], 'between': [911, 1590, 1597, 1635, 3472], 'fifth': [913], 'sixth': [915], '(10Michikawa': [918, 3549], 'Hamanaka': [920, 3551], 'Otsu': [922, 3553], 'Tashiro': [930, 3561], '1994;': [937, 3568], '269:': [938, 3569], '9184-9189Abstract': [939, 3570], '11Boehning': [946], 'Joseph': [948, 4491], 'Mak': [950, 4493], 'D.O.': [951, 4494], 'Foskett': [952, 4495], 'J.K.': [953, 4496], 'Biophys.': [954, 1247, 4497], '2001;': [956, 4499], '81:': [957, 4500], '117-124Abstract': [958], '(52)': [966], 'primary': [970], 'sequence': [971], 'domain': [975, 1392, 1546, 1642, 3461], 'adjacent': [976], 'pore-forming': [979], 'homologous': [983], '(RyR),': [990], 'another': [991], 'type': [992], 'suggesting': [998, 1928], 'might': [1003], 'share': [1004], 'common': [1006], 'ions.': [1013], 'Each': [1014], 'subunit': [1016, 1586], 'single': [1019, 1346, 3773], 'high': [1020, 3774], 'affinity': [1021, 1488, 3775, 3909, 3920, 3939, 3950], 'site': [1023, 2132, 2325, 3777], 'core,': [1052, 1176, 1531], 'minimum': [1054], 'specific': [1058], '(12Yoshikawa': [1061, 1204, 3971], 'F.': [1062, 1146, 1205, 1233, 1548, 1604, 2631, 3241, 3377, 3972], 'Morita': [1063, 1206, 3973], 'Monkawa': [1065, 1208, 3975], '1996;': [1076, 1219, 3986], '271:': [1077, 1220, 3987], '18277-18284Abstract': [1078, 1221, 3988], '(201)': [1086, 1229, 3996], 'resides': [1089], '226–578': [1092], 'mouse': [1094, 1419, 1515, 1969, 2030, 2062, 2139, 2285, 2334, 2372, 2666, 3441, 3801], '(2749': [1096], 'amino': [1097, 1126], 'acids)': [1098], '(13Furuichi': [1099, 1421, 2339, 2377], 'Wada': [1105, 1427, 2345, 2383], 'Maeda': [1107, 1429, 1462, 1496, 2039, 2347, 2385, 2431, 3830], '1989;': [1112, 1434, 1681, 2352, 2390], '342:': [1113, 1435, 2353, 2391], '32-38Crossref': [1114, 1436, 2354, 2392], '(898)': [1117, 1439, 2357, 2395], '11': [1123], 'basic': [1125], 'acids': [1127], '(14Bosanac': [1131], 'I.': [1132, 1288, 1835, 4450], 'Alattia': [1133], 'J.R.': [1134], 'Mal': [1135], 'T.K.': [1136], 'Chan': [1137], 'Talarico': [1139], 'Tong': [1141, 1143], 'F.K.': [1142], 'K.I.': [1144], 'Iwai': [1149], 'Ikura': [1155], '2002;': [1158], '420:': [1159], '696-700Crossref': [1160], '(287)': [1163], '225': [1168], 'residues,': [1169], 'close': [1172, 3792], 'have': [1177], 'thought': [1179, 1394], 'function': [1181], 'suppressor': [1184, 3967], 'because': [1188, 1405, 1768], 'their': [1189, 1648], '734-amino': [1194], 'acid': [1195], 'significant': [1199, 1577, 3717], 'enhancement': [1200], 'activity': [1203, 3719, 3737, 4311, 4375], '15Yoshikawa': [1232], 'Uchiyama': [1234], 'Iwasaki': [1236, 1549, 1605, 2632, 3242, 3378], 'Tomomori-Satoh': [1238], 'C.': [1239, 2231], 'Tanaka': [1240], 'Res.': [1248], 'Commun.': [1249], '257:': [1251], '792-797Crossref': [1252], '(42)': [1255], 'IICR': [1258, 1578, 1654, 4316], 'positively': [1261], 'cooperative': [1262, 4011], 'process': [1263], '(16Meyer': [1264], 'Wensel': [1266], 'Stryer': [1268, 1692, 1745, 1781], 'L.': [1269, 1693, 1746, 1782], 'Biochemistry.': [1270], '1990;': [1271, 1376, 1701, 1754, 1790, 2044, 2436, 3811, 3835, 4020], '29:': [1272], '32-37Crossref': [1273], '(159)': [1276], '17Hirota': [1279], 'Okura': [1287, 1834, 4449], '19046-19051Abstract': [1296, 1843, 4458], '(44)': [1304, 1851, 4466], '18Michikawa': [1307], 'Hirota': [1309, 2675], 'Kawano': [1311, 2677], 'Hiraoka': [1313, 2679], 'Yamada': [1315, 2681], 'Neuron.': [1321, 2043, 2435, 2687, 3834], '23:': [1323, 2689], '799-808Abstract': [1324, 2690], '(150)': [1332, 2698], 'i.e.': [1335], 'molecules': [1343], 'elicits': [1357], 'large': [1359], 'conformational': [1360], 'change': [1361], 'portion': [1366, 1417], '(19Mignery': [1370], 'Südhof': [1372], '9:': [1377, 3812, 4021], '3893-3898Crossref': [1378], '(277)': [1381, 1911], 'Furthermore,': [1384], 'involved': [1397], '(mAb)': [1408], '18A10,': [1409], 'whose': [1410, 3539], 'epitope': [1411, 3540], '20Maeda': [1442], 'Niinobe': [1444, 3618, 3805, 4014], 'Nakahira': [1446, 3620], '1988;': [1452, 3626, 4039], '51:': [1453, 3627], '1724-1730Crossref': [1454, 3628], '21Nakade': [1460], '277:': [1469, 1503], '125-131Crossref': [1470, 1504], '(86)': [1473, 1507], 'an': [1477, 1774, 1879, 2130, 2200, 2802, 2861, 3329, 3587, 3641, 4435], 'inhibitory': [1478], 'effect': [1479, 1594], 'IICR,': [1481], 'without': [1482], 'causing': [1483], 'decrease': [1485], '(21Nakade': [1494], 'Controlled': [1510], 'trypsinization': [1511, 3283], 'induces': [1512], 'fragmentation': [1513], 'five': [1518], 'major': [1519], 'fragments,': [1520, 1526], 'all': [1522, 4059], 'contain': [1528], 'associated': [1533], 'directly': [1534], 'indirectly': [1536], 'with': [1537, 1738, 2017, 2291, 2488, 2594, 2662, 2701, 2711, 2978, 3024, 3054, 3095, 3119, 3278, 3360, 3512, 3586, 3644, 3778, 3956], 'remaining': [1539], 'fragment,': [1541], '(22Yoshikawa': [1547, 1603, 2630, 3240, 3376], '316-327Abstract': [1562, 1618, 2645, 3255, 3391], '(93)': [1570, 1626, 2653, 3263, 3399], 'trypsinized': [1574], 'retains': [1576], 'indicating': [1580, 1871, 3651, 4359, 4418], 'intramolecular': [1582], 'and/or': [1587, 2597], 'neighboring': [1591], 'could': [1593], 'However,': [1629], 'interfaces': [1634], 'fragments': [1638, 2414], 'remain': [1650], 'elucidated.': [1653], 'shown': [1657, 3635], 'occur': [1659], 'quantal': [1662, 1823, 1874, 1931, 4427], 'manner': [1663], 'permeabilized': [1665], 'isolated': [1668, 2176, 2219, 2336, 2374], 'membranes': [1671], '(23Muallem': [1672], 'Pandol': [1674], 'S.J.': [1675], 'Beeker': [1676], 'T.G.': [1677], '264:': [1682], '205-212Abstract': [1683], '24Meyer': [1690], '87:': [1702, 1755, 1791], '3841-3845Crossref': [1703, 1756, 1792], 'addition': [1710, 3134, 3166, 3312, 3327, 4353, 4397], 'submaximal': [1712], 'concentrations': [1713, 3188, 4400], 'presence': [1718, 3036, 4331], 'pump': [1721, 4335], 'inhibitors': [1722, 2738, 2888], 'leads': [1723], 'partial': [1726], 'sequestered': [1729], 'Ca2+,': [1730, 3186], 'amount': [1733, 4087], 'released': [1735], 'varies': [1737], 'concentration': [1740, 2892, 3084, 4414], '(24Meyer': [1743, 1779], 'Although': [1762], 'terminates': [1766], 'abruptly,': [1767], 'can': [1770], 'reinitiated': [1772], 'additional': [1775, 3642], 'increment': [1776], 'IP3concentration': [1778], 'rapid': [1799], 'termination': [1800], 'due': [1806], 'ordinary': [1808], 'inactivation': [1809], 'desensitization': [1811], 'receptor.': [1814], 'Purified': [1815], 'reconstituted': [1817], 'lipid': [1819], 'vesicles': [1820], 'reveal': [1821], 'flux': [1825], '(17Hirota': [1826, 4441], '25Ferris': [1854, 4469], 'C.D.': [1855, 4470], 'Cameron': [1856, 4471], 'A.M.': [1857, 4472], 'Huganir': [1858, 4473], 'R.L.': [1859, 4474], 'Snyder': [1860, 4034, 4475], 'S.H.': [1861, 4035, 4476], '1992;': [1863, 4478], '356:': [1864, 4479], '350-352Crossref': [1865, 4480], '(112)': [1868, 4483], 'intrinsic': [1880, 2201, 3153, 4436], 'property': [1881, 1938, 4051, 4437], 'IP3R.': [1884, 2026], 'Similar': [1885], 'behavior': [1886], 'was': [1887, 2055, 2133, 2182, 2258, 2289, 2360, 2398, 2590, 2625, 2767, 2781, 2799, 2831, 2843, 2857, 2900, 2937, 3032, 3090, 3145, 3169, 3235, 3308, 3595, 3649, 3715, 3928, 4096, 4327, 4341], 'observed': [1888, 1918, 4342], 'RyR,': [1891], 'Ca2+-induced': [1894], 'stores': [1900], '(26Györke': [1901], 'Fill': [1903], 'Science.': [1905], '260:': [1907, 3222], '807-809Crossref': [1908], 'other': [1920], 'ligand-gated': [1921], 'membrane,': [1927], 'fundamental': [1935], 'unique': [1937], 'channels.': [1944], 'basis': [1949], 'IP3R,': [1956], 'series': [1960], 'site-directed': [1966, 2287], 'expressed': [1971, 3671, 3741, 3767, 3798, 3822, 4066, 4091, 4104, 4269, 4298, 4378, 4421], 'R23-11': [1975, 2461, 2522, 3503, 3660, 3673, 3727, 3769, 4068, 4348, 4362, 4423], '(27Sugawara': [1977, 2105, 2463, 2529], 'Kurosaki': [1979, 1983, 2107, 2111, 2465, 2469, 2531, 2535], 'Takata': [1981, 2109, 2467, 2533], '16:': [1988, 2116, 2474, 2540], '3078-3088Crossref': [1989, 2117, 2475, 2541], '(378)': [1992, 2120, 2478, 2544], 'found': [1996], 'IP3-dependent': [2009], 'findings': [2014], 'provide': [2015], 'us': [2016], 'new': [2018, 4294], 'insight': [2019], 'For': [2027], 'transfection': [2028, 4368], 'wild-type': [2031, 3271, 3756, 3914, 4056, 4131, 4393], 'cDNA,': [2033], 'pBact-STneoB-C1': [2034], '(28Miyawaki': [2035, 2427, 3826], '5:': [2045, 2437, 3836], '11-18Abstract': [2046, 2438, 3837], '(121)': [2052, 2444, 3843], 'Scholar)': [2054, 2122, 2257, 2359, 2397, 2446, 2480, 2546, 3818], 'used.': [2056, 2932], 'Seven': [2057], 'mutant': [2059, 3273, 3495, 3500, 3580, 3669, 3759, 3922, 3934, 4062, 4102, 4314], 'cDNAs': [2060, 2422, 3501], 'D651–1130,': [2064], 'D1131–1379,': [2065, 3902], 'D1267–2110,': [2066, 3924], 'D1692–1731,': [2067, 3903], 'D1845–2042,': [2068, 3925], 'D1845–2216,': [2069], 'D2610–2748': [2071, 3583, 3594, 3607, 3657], 'were': [2101, 2404, 2415, 2423, 2456, 2481, 2517, 2570, 2658, 2705, 2917, 2976, 3012, 3022, 3047, 3114, 3191, 3205, 3276, 3338, 3349, 3584, 3675, 4105, 4145], 'subcloned': [2102, 2361, 2399, 2424], 'pAneo': [2104], 'SalI': [2125, 2449], 'sites.': [2126, 2450], 'construct': [2128, 2215], 'D1–223,': [2129], 'XhoI': [2131], 'introduced': [2134, 3498], 'nucleotide': [2136], '998': [2137], 'PCR': [2142, 2452], 'using': [2143, 2296, 2599, 3534, 3612, 3743, 4361], 'green': [2144, 2178, 2222], 'fluorescent': [2145, 2179, 2223], 'protein-fused': [2146, 2180, 2224], 'IP3R-D223': [2147, 2181], '2Y.': [2148], 'Tateishi,': [2149], 'Hattori,': [2151], 'Michikawa,': [2153, 2560], 'Iwai,': [2155], 'Uchida,': [2157, 2556], 'Nakayama,': [2159], 'Nakamura,': [2161], 'Inoue,': [2163], 'Mikoshiba,': [2166, 2563], 'unpublished': [2167], 'data.': [2168], 'template': [2171, 2407], 'DNA.': [2172], 'XhoI-KpnI': [2174], 'fragment': [2175, 2187, 2218, 2263, 2321, 2367], 'ligated': [2183, 2259], 'SalI-KpnI': [2186], 'pBact-STneoB-C1.': [2189, 2265], 'resultant': [2191], 'plasmid,': [2192], 'pBact-STneoB-D1–223,': [2193], 'uses': [2194], 'nucleotides': [2195, 2304, 2308, 2312, 2317], '998–1000,': [2196], 'correspond': [2198], 'methionine': [2202], '224,': [2206], 'start': [2209], 'codon': [2210], '(ATG)': [2211], 'transcription.': [2213], 'D2736–2749,': [2216], 'aKpnI-XhoI': [2217], 'enhanced': [2221], 'IP3R/Δ18A10': [2225], '(29Zhang': [2226], 'Mizutani': [2228], 'Hisatsune': [2230], 'Higo': [2232], 'Bannai': [2234], 'Nakayama': [2236], 'Hattori': [2238], '2003;': [2245], '278:': [2246], '4048-4056Abstract': [2247], '(72)': [2255], 'KpnI-SalI': [2262], 'substitute': [2267], 'serine': [2268], '1976,': [2273], '2610,': [2274], '2613': [2276, 2283], 'positions': [2280], '2610': [2281], 'mutagenesis': [2288], 'performed': [2290, 2626, 2938, 3236], 'MutanK': [2293], 'kit': [2294], '(Takara)': [2295], 'primers': [2297], 'containing': [2298, 2574, 2736, 2826, 2886, 3450], 'appropriate': [2300, 2803, 2862, 3588], 'substitutions': [2301], '(5′-GTGGTTTTCAGACAGCAGCTG-3′': [2302], '6245–6265,': [2305], '5′-CAGATGAAGCTCGTGGTTTTT-3′': [2306], '8146–8166,': [2309], '5′-TTCCAAGCCGGAGATGAAGCA-3′': [2310], '8156–8176,': [2313], '5′-AAGCCGGAGATGAAGCTCGTGGT-3′': [2315], '8150–8172).': [2318], 'EcoRI': [2320, 2324], '(nucleotide': [2326], '6979)': [2327], '3′-end': [2331], 'pBactS-C1': [2338, 2376], 'pBluescript': [2363], 'SK(+).': [2364], 'BamHI': [2366, 2413], '(2532': [2368], 'bp)': [2369], 'pUC118.': [2401], 'plasmids': [2403, 2516], 'used': [2405, 2919, 3081, 4119], 'DNAs.': [2408], 'After': [2409, 3008, 3325], 'mutatedEcoRI': [2411], 'put': [2416], 'back': [2417], 'pBactS-C1,': [2419], 'mutated': [2421], 'pBact-STneoB': [2426], 'All': [2451, 3577], 'products': [2453], 'mutations': [2455], 'confirmed': [2457, 2591, 3603], 'DNA': [2459], 'sequencing.': [2460], 'cultured': [2482], 'RPMI': [2484], '1640': [2485], 'medium': [2486, 2573], 'supplemented': [2487, 3053], '107': [2489, 2621], 'fetal': [2490], 'calf': [2491], 'serum,': [2492, 2495], '17': [2493, 3436], 'chicken': [2494], '50': [2496, 2610, 2881, 3314], 'ॖm': [2497, 2743, 2746, 2751, 3039, 3075], '2-mercaptoethanol,': [2498, 2729, 2819, 2879, 3293], '4': [2499, 3006], 'mm': [2500, 2608, 2611, 2616, 2722, 2725, 2728, 2732, 2809, 2812, 2815, 2818, 2822, 2869, 2872, 2875, 2878, 2882, 2991, 2996, 3000, 3060, 3137, 3200, 3286, 3289, 3292, 3296, 3322], 'glutamine,': [2501], '100': [2502, 2506, 2615, 2904, 2985], 'units/ml': [2503], 'penicillin,': [2504], 'ॖg/ml': [2507, 3056, 3063, 3087, 3280, 3315], 'streptomycin': [2508], '39.5': [2510], '°C': [2511, 2930, 3302, 3342], '57': [2513], 'CO2.': [2514], 'Expression': [2515, 2583], 'linearized': [2518], 'transfected': [2520], 'electroporation': [2525], 'previously': [2527, 2629, 2941, 3239, 3403, 3684, 4487], 'described': [2528, 2628, 2668, 2940, 3238, 3683], 'lipofection': [2549], '(Effectene,': [2550], 'QIAGEN': [2551], 'Inc.).': [2552], '3H.': [2553], 'Miyauchi,': [2554], 'Kirino,': [2558], 'manuscript': [2564], 'preparation.': [2566], 'Several': [2567], 'stable': [2568, 3507, 3531, 3749, 4121, 4324], 'clones': [2569], 'selected': [2571, 3447], '2': [2575, 2777, 2795, 2853, 3059, 3074, 3143, 3199, 3513], 'mg/ml': [2576, 2895, 3514], 'G418': [2577], '(Sigma)': [2578, 3319], '∼7–10': [2579], 'days': [2580], 'after': [2581, 4351, 4395], 'transfection.': [2582], 'its': [2588], 'immunoblotting': [2593], 'mAbs': [2595], '4C11': [2596, 3615], '18A10': [2598, 3368], 'lysates': [2601], 'boiled': [2602], 'SDS-PAGE': [2604, 3333, 3353], 'sample': [2605, 3334], 'buffer': [2606, 2720, 2807, 2867, 2899, 2989, 3052, 3284], '(5': [2607, 2721], 'EDTA,': [2609, 3290], 'Tris-HCl,': [2612, 2992, 3297], 'pH': [2613, 2734, 2824, 2884, 2993, 3298], '6.8,': [2614], 'dithiothreitol,': [2617], '27': [2618], 'SDS,': [2619], 'glycerol).': [2622], 'Immunoblot': [2623], 'analysis': [2624, 3523, 3611, 3681], 'Membrane': [2656], 'fractions': [2657, 2916, 2973, 3046, 3163, 3267, 3527, 3745, 4320, 4345], 'prepared': [2659, 3528, 4321, 4346], 'accordance': [2661], 'protocol': [2664], 'cerebella': [2667], 'et': [2671], 'al.': [2672], '(18Michikawa': [2673], 'minor': [2702], 'modifications.': [2703], 'Cells': [2704], 'collected': [2706], 'centrifugation,': [2708, 3009], 'washed': [2709], 'twice': [2710], 'cold': [2712], 'phosphate-buffered': [2713], 'saline,': [2714], 'homogenized': [2716], 'ice-cold': [2718], 'homogenization': [2719], 'NaN3,': [2723, 2813], '0.1': [2724, 3321], 'EGTA,': [2726, 2997], '1': [2727, 2817, 2877, 2995, 2999, 3055, 3136, 3288, 3291], '20': [2731, 2814, 3295, 3783], 'HEPES-NaOH,': [2733], '7.4)': [2735], 'protease': [2737, 2827, 2887], '(0.1': [2739], 'mmphenylmethylsulfonyl': [2740], 'fluoride,': [2741], '10': [2742, 2745, 2750, 2774, 2821, 2838, 2871, 3003, 3038, 3069, 3203, 3304, 4355], 'leupeptin,': [2744], 'pepstatin': [2747], 'A,': [2748], 'E-64)': [2752], '40': [2754], 'strokes': [2755], 'chilled': [2758], 'glass-Teflon': [2759], 'Potter': [2760], 'homogenizer': [2761], '1000': [2763], 'rpm.': [2764], 'homogenate': [2766], 'centrifuged': [2768, 2782, 2832, 2844], '1100': [2770, 2834], '×': [2771, 2835, 2847], 'g': [2772, 2836, 2848], 'min': [2775, 2793, 2851, 3004], '°C.': [2778, 2796, 2854, 3007, 3126], 'supernatant': [2780, 2842], '100,000': [2784], '×g': [2785], 'Beckman': [2788], 'TLA100.3': [2789], 'rotor': [2790], '30': [2792, 2850, 3125, 3344], 'pellet': [2798, 2856], 'resuspended': [2800], 'volume': [2804, 2863, 3331], 'wash': [2806], '(600': [2808], 'KCl,': [2810, 2870, 3287], '5': [2811, 2874, 3785], 'Na4P2O5,': [2816], 'HEPES-HCl,': [2823], '7.2)': [2825, 2885], 'inhibitors.': [2828], 'suspension': [2830], 'min,': [2839], '63,000': [2846], 'finally': [2858], 'suspended': [2859, 3048], '(110': [2868], 'NaCl,': [2873], 'KH2PO4,': [2876], 'HEPES-KOH,': [2883], 'final': [2891], '∼15': [2894], 'protein.': [2896, 3088], 'passed': [2901], 'over': [2902], 'Chelex': [2903], '(Bio-Rad)': [2905], 'eliminate': [2907, 3148], 'extra': [2909], 'free': [2910, 3185], 'before': [2912], 'use.': [2913], 'either': [2918], 'immediately': [2920], 'frozen': [2922], 'liquid': [2924], 'nitrogen': [2925], 'stored': [2927], '−80': [2929], 'until': [2931], 'assay': [2936], '(50–200': [2974], 'ॖg/tube)': [2975], 'incubated': [2977, 3277, 3339], '9.6': [2979], 'nm[3H]IP3': [2980], '(PerkinElmer': [2981, 3016], 'Life': [2982, 3017], 'Sciences)': [2983], 'ॖl': [2986], '(50': [2990], '8.0,': [2994], '2-mercaptoethanol)': [3001], 'pellets': [3011], 'dissolved': [3013], 'Solvable': [3015], 'Sciences),': [3018], 'radioactivities': [3021], 'measured': [3023, 3033, 3676, 3734, 4328], 'scintillation': [3026], 'counter': [3027], '(Beckman': [3028], 'LS6500).': [3029], 'Nonspecific': [3030], 'unlabeled': [3040], '(Dojindo': [3042], 'Laboratories).': [3043], 'oligomycin': [3057], '(Sigma),': [3058, 3072], 'MgCl2,': [3061], '25': [3062], 'creatine': [3064], 'kinase': [3065], '(Roche': [3066], 'Applied': [3067], 'Science),': [3068], 'mmcreatine': [3070], 'phosphate': [3071], 'Fura-2': [3076], '(Molecular': [3077], 'Probes,': [3078], 'Inc.)': [3079], '200–300': [3086], 'Fluorescence': [3089], 'recorded': [3091, 3115], '510': [3093], 'nm': [3094, 3102, 3184], 'alternate': [3096], 'excitation': [3097], '340': [3099], '380': [3101], '(F340': [3103], 'andF380,': [3104], 'respectively).': [3105], 'CAF-110': [3108], 'spectrofluorometer': [3109], '(Japan': [3110], 'Spectroscopic': [3111], 'Co.),': [3112], 'every': [3116], '0.01': [3117, 4195, 4285], 's': [3118], 'MacLab': [3120], 'Version': [3121], '3.6': [3122], '(ADInstruments)': [3123], 'When': [3127, 3172], 'uptake': [3130, 3151], 'induced': [3131], 'ATP': [3138], 'reached': [3139, 3179], 'steady': [3141], 'level,': [3142], 'ॖmthapsigargin': [3144], 'added': [3146, 3206], 'active': [3149], 'through': [3152], 'pumps.': [3155], 'rate': [3157, 4405], 'leakage': [3159], 'thapsigargin': [3168], 'almost': [3170], 'linear.': [3171], 'ratio': [3174], 'fluorescence': [3176], 'intensity': [3177], '(F340/F380)': [3178], '1.2,': [3180], 'corresponding': [3181], '∼170': [3183], 'added.': [3192], 'At': [3193], 'end': [3195], 'each': [3197, 4093, 4323], 'experiment,': [3198], 'CaCl2': [3201], 'mmEGTA': [3204], 'successively': [3207], 'normalization': [3209], 'calibration': [3211], '(30Grynkiewicz': [3212], 'G.': [3213], 'Poenie': [3214], 'Tsien': [3216], 'R.Y.': [3217], '1985;': [3221], '3440-3450Abstract': [3223], '(80)': [3229], 'Microsomal': [3266], '(0.25–5': [3268], 'mg/ml)': [3269], 'IP3R1-expressing': [3274], '0.01–10': [3279], '(120': [3285], '8.0)': [3299], '35': [3301], 'min.': [3305, 3345], 'reaction': [3307, 3336], 'terminated': [3309], 'soybean': [3316], 'inhibitor': [3318, 4336], 'phenylmethylsulfonyl': [3323], 'fluoride.': [3324], 'equal': [3330], 'buffer,': [3335], 'mixtures': [3337], '55': [3341], 'digested': [3347], 'proteins': [3348], 'separated': [3350], '87': [3352], 'then': [3355], 'Western': [3358, 3521, 3609, 4074], 'blotting': [3359], 'anti-IP3R1': [3361, 3535, 3613], 'antibodies': [3362], 'N1,': [3363], '4C11,': [3364], '10A6,': [3365], '1ML1,': [3366, 3538, 3601], 'anti-(1718–31)': [3371], '(see': [3373], 'Fig.': [3374, 3637, 4380], '1A)': [3375, 3548], 'As': [3402, 3634, 4486], 'reported': [3404, 4002, 4488], 'constructed': [3435, 3481], 'Among': [3443], 'seven': [3448], '(Fig.1B)': [3449], '(residues': [3455, 3462], '226–578)': [3456], '2276–2589)': [3463], 'investigate': [3465, 4307], 'ligand': [3473], 'addition,': [3479], 'respectively': [3489, 4156], '(Fig.': [3490, 3547, 3591, 4076, 4357], '1B).': [3491], 'express': [3493], 'receptors,': [3496], 'established': [3506], 'lines': [3509, 3533, 4123], 'selection': [3511], 'G418.': [3515], 'Fig.2A': [3516], 'illustrates': [3517], 'blot': [3522, 3610, 4075], 'polyclonal': [3536], 'lies': [3541], '2504–2523': [3544], 'except': [3582, 4064], 'detected': [3585], 'mass': [3590, 3648], '2A).': [3592], 'Because': [3593], 'well': [3597], 'recognized': [3598], 'expression': [3605], 'mAb': [3614], '(20Maeda': [3616], '2B': [3638], '(open': [3639], 'arrowhead),': [3640], 'low': [3646], 'detected,': [3650], 'degradation': [3653], '(or': [3654], 'truncation)': [3655], 'occurs': [3658], 'cells.': [3661], 'activities': [3664], 'equilibrium': [3678], '[3H]IP3': [3679], 'no': [3716], 'fraction': [3723], 'obtained': [3724, 3746], '(data': [3729], 'shown).': [3731], 'Therefore,': [3732], 'exogenously': [3740, 4377], 'lines.': [3751], 'summarized': [3762], 'TableI.': [3764], 'Wild-type': [3765], 'dissociation': [3780], 'constant': [3781], '±': [3784, 4147, 4151, 4170, 4172, 4174, 4177, 4179, 4181, 4183, 4190, 4192, 4200, 4207, 4209, 4211, 4213, 4215, 4217, 4224, 4226, 4228, 4230, 4232, 4234, 4241, 4243, 4245, 4252, 4254, 4256, 4258, 4260, 4262, 4264, 4266, 4272, 4301], 'nm(n': [3786], '=': [3787, 4275, 4304], '3).': [3788, 4305], 'This': [3789], 'value': [3790], 'native': [3796, 4439], 'cerebellum': [3802], '(31Maeda': [3803, 4012], '61-67Crossref': [3813, 4022], '(234)': [3816, 4025], 'cDNA-derived': [3820], 'L': [3824], 'NG108-15': [3846], 'Sf9': [3878], '(32Yoneshima': [3880], '322:': [3893], '591-596Crossref': [3894], '(89)': [3897], 'Mutant': [3900, 3944], 'D2610–2748,': [3904], 'D2736–2749': [3906], 'exhibited': [3907], 'similar': [3910], '(Table': [3916, 3931, 3942, 3953, 4070, 4081, 4114, 4157], 'I).': [3917, 3943, 4071], 'D1845–2216': [3927], '2–3-fold': [3929], 'lower': [3930, 3938], 'I),': [3932, 3954], 'D651–1130': [3935], 'had': [3936], '7.5-fold': [3937], 'D1–223': [3945, 4065], 'exhibited,': [3946], 'however,': [3947], 'significantly': [3948], 'higher': [3949], 'consistent': [3955], 'previous': [3958], 'report': [3959], 'showing': [3960], 'act': [3964], 'It': [3999], '33Supattapone': [4028], 'Worley': [4030], 'P.F.': [4031], 'Baraban': [4032], 'J.M.': [4033], '263:': [4040], '1530-1534Abstract': [4041], 'same': [4050], 'holds': [4052], 'true': [4053], 'Both': [4072, 4403], '2)': [4077], 'I)': [4082], 'analyses': [4083], 'protein': [4090, 4113], 'line': [4095, 4326], 'different.': [4097], 'amounts': [4099, 4129], 'range': [4108], '1.5–9.2': [4110], 'pmol/mg': [4111, 4153], 'I);': [4115], 'therefore,': [4117], '(KMN13': [4124], 'KMN107)2': [4126], 'expressing': [4127], 'different': [4128], 'controls': [4134], 'experiments.': [4138], 'TheBmax': [4139], 'values': [4140], 'KMN13': [4142], 'KMN107': [4144], '13': [4146], '9': [4148], '0.77': [4150], '0.2': [4152], 'protein,': [4155], 'I).Table': [4158], 'IIP3-binding': [4159], 'mutantsRecombinant': [4164], 'proteinAffinity': [4165], '(Kd)BmaxHill': [4166], 'coefficientnmpmol/mg': [4167], 'proteinWild-type': [4168], 'KMN1320': [4169], '513': [4171], '91.0': [4173], '0.05': [4175, 4186, 4203, 4220, 4237, 4248, 4279], 'KMN10777': [4176], '500.77': [4178], '0.20.97': [4180], '0.02D1-2231.5': [4182], '0.41-ap': [4184], '<': [4185, 4194, 4202, 4219, 4236, 4247, 4278, 4284], "Student's": [4188, 4197, 4205, 4222, 4239, 4250, 4281, 4287], 'ttest.14': [4189], '31.5': [4191], '0.21-bp': [4193], 't': [4198, 4288], 'test.D651-1130150': [4199], '301-ap': [4201], 'ttest.5.2': [4206], '30.85': [4208], '0.1D1131-137912': [4210], '19.2': [4212], '71.1': [4214], '0.2D1267-211057': [4216], '51-ap': [4218], 'ttest.4.2': [4223], '11.0': [4225, 4259], '0.04D1692-173122': [4227], '63.8': [4229], '20.99': [4231], '0.05D1845-204241': [4233], '31-ap': [4235], 'ttest.1.7': [4240], '0.91.0': [4242], '0.08D1845-221648': [4244], '101-ap': [4246], 'ttest.2.1': [4251], '0.50.92': [4253], '0.02D2610-274867': [4255], '501.5': [4257], '0.07D2736-274923': [4261], '57.2': [4263], '0.40.95': [4265], '0.07Values': [4267], 'means': [4271, 4300], 'S.D.': [4273, 4302], '(n': [4274, 4303], '3).1-a': [4276], 'p': [4277, 4283], 'ttest.1-b': [4282], 'test.': [4289], 'Open': [4290], 'table': [4291], 'tab': [4295], 'Values': [4296], 'IP3Rs,': [4315], 'thapsigargin.': [4337], 'No': [4338], 'even': [4350], 'ॖmIP3': [4356], '3A),': [4358], 'allows': [4369], 'evaluation': [4370], 'definite': [4372], 'IP3Rs.': [4379], '3B': [4381], 'shows': [4382], 'time': [4384], 'course': [4385], 'mediated': [4390], 'recombinant': [4392], 'IP3.': [4402], 'amplitude': [4407], 'depended': [4411], 'added,': [4417], 'exhibits': [4425], 'known': [4432], '(11Boehning': [4489]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2008906006', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-24T15:35:04.899358', 'created_date': '2016-06-24'}
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