Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2113366653', 'doi': 'https://doi.org/10.4161/chan.5.1.14031', 'title': 'Open- and closed-state fast inactivation in sodium channels', 'display_name': 'Open- and closed-state fast inactivation in sodium channels', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2113366653', 'doi': 'https://doi.org/10.4161/chan.5.1.14031', 'mag': '2113366653', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21099342', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3052208'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/chan.5.1.14031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202658786', 'display_name': 'Channels', 'issn_l': '1933-6950', 'issn': ['1933-6950', '1933-6969'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.4161/chan.5.1.14031', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001641334', 'display_name': 'James R. Groome', 'orcid': 'https://orcid.org/0000-0003-2534-2499'}, 'institutions': [{'id': 'https://openalex.org/I106969075', 'display_name': 'Idaho State University', 'ror': 'https://ror.org/0162z8b04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I106969075']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'James Groome', 'raw_affiliation_strings': ['Idaho State University'], 'affiliations': [{'raw_affiliation_string': 'Idaho State University', 'institution_ids': ['https://openalex.org/I106969075']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045210310', 'display_name': 'Frank Lehmann‐Horn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank Lehmann-Horn', 'raw_affiliation_strings': ['Ulm, Tubingen Germany', 'University of Ulm'], 'affiliations': [{'raw_affiliation_string': 'Ulm, Tubingen Germany', 'institution_ids': []}, {'raw_affiliation_string': 'University of Ulm', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062438684', 'display_name': 'Boris Holzherr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Boris Holzherr', 'raw_affiliation_strings': ['Ulm, Tubingen Germany', 'University of Ulm'], 'affiliations': [{'raw_affiliation_string': 'Ulm, Tubingen Germany', 'institution_ids': []}, {'raw_affiliation_string': 'University of Ulm', 'institution_ids': ['https://openalex.org/I196349391']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5001641334'], 'corresponding_institution_ids': ['https://openalex.org/I106969075'], 'apc_list': {'value': 1880, 'currency': 'GBP', 'value_usd': 2306, 'provenance': 'doaj'}, 'apc_paid': {'value': 1880, 'currency': 'GBP', 'value_usd': 2306, 'provenance': 'doaj'}, 'fwci': 0.818, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.801224, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '5', 'issue': '1', 'first_page': '65', 'last_page': '78'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/voltage-gated-channels', 'display_name': 'Voltage-Gated Channels', 'score': 0.497632}], 'concepts': [{'id': 'https://openalex.org/C194544171', 'wikidata': 'https://www.wikidata.org/wiki/Q21105679', 'display_name': 'Gating', 'level': 2, 'score': 0.9360869}, {'id': 'https://openalex.org/C4141045', 'wikidata': 'https://www.wikidata.org/wiki/Q83183', 'display_name': 'Depolarization', 'level': 2, 'score': 0.81001985}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.7779895}, {'id': 'https://openalex.org/C50952357', 'wikidata': 'https://www.wikidata.org/wiki/Q424960', 'display_name': 'Sodium channel', 'level': 3, 'score': 0.7592275}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.74202085}, {'id': 'https://openalex.org/C181911157', 'wikidata': 'https://www.wikidata.org/wiki/Q389844', 'display_name': 'Membrane potential', 'level': 2, 'score': 0.58226234}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.5023079}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.44586787}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.35704392}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31728166}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.13854599}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.116003245}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003064', 'descriptor_name': 'Cnidarian Venoms', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012615', 'descriptor_name': 'Sea Anemones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003064', 'descriptor_name': 'Cnidarian Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D062553', 'descriptor_name': 'NAV1.4 Voltage-Gated Sodium Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/chan.5.1.14031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202658786', 'display_name': 'Channels', 'issn_l': '1933-6950', 'issn': ['1933-6950', '1933-6969'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3052208', 'pdf_url': 'https://europepmc.org/articles/pmc3052208?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052208', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21099342', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/chan.5.1.14031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S202658786', 'display_name': 'Channels', 'issn_l': '1933-6950', 'issn': ['1933-6950', '1933-6969'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1509844096', 'https://openalex.org/W1760502256', 'https://openalex.org/W1965522673', 'https://openalex.org/W1966093407', 'https://openalex.org/W1968903551', 'https://openalex.org/W1971393605', 'https://openalex.org/W1972459374', 'https://openalex.org/W1973420297', 'https://openalex.org/W1976877406', 'https://openalex.org/W1977073662', 'https://openalex.org/W1980015500', 'https://openalex.org/W1983187084', 'https://openalex.org/W1985940938', 'https://openalex.org/W1989930526', 'https://openalex.org/W1990091466', 'https://openalex.org/W1996437700', 'https://openalex.org/W2002568518', 'https://openalex.org/W2003688138', 'https://openalex.org/W2004706540', 'https://openalex.org/W2010248111', 'https://openalex.org/W2018764168', 'https://openalex.org/W2026472308', 'https://openalex.org/W2029122690', 'https://openalex.org/W2047303876', 'https://openalex.org/W2048268501', 'https://openalex.org/W2054008220', 'https://openalex.org/W2054339320', 'https://openalex.org/W2055097743', 'https://openalex.org/W2057528897', 'https://openalex.org/W2057925083', 'https://openalex.org/W2060126253', 'https://openalex.org/W2061695857', 'https://openalex.org/W2075977700', 'https://openalex.org/W2076378327', 'https://openalex.org/W2077636083', 'https://openalex.org/W2082563883', 'https://openalex.org/W2085498070', 'https://openalex.org/W2094677101', 'https://openalex.org/W2095581992', 'https://openalex.org/W2099344620', 'https://openalex.org/W2103291395', 'https://openalex.org/W2103703341', 'https://openalex.org/W2109873920', 'https://openalex.org/W2114682026', 'https://openalex.org/W2126725618', 'https://openalex.org/W2129134088', 'https://openalex.org/W2138173592', 'https://openalex.org/W2138386595', 'https://openalex.org/W2138839177', 'https://openalex.org/W2147805912', 'https://openalex.org/W2158426869', 'https://openalex.org/W2167862640', 'https://openalex.org/W2169803747', 'https://openalex.org/W2170154282', 'https://openalex.org/W2338114398', 'https://openalex.org/W4253271002'], 'related_works': ['https://openalex.org/W4255426901', 'https://openalex.org/W2111857563', 'https://openalex.org/W2060662231', 'https://openalex.org/W2055246478', 'https://openalex.org/W2039760353', 'https://openalex.org/W2026124448', 'https://openalex.org/W2024012135', 'https://openalex.org/W1991683799', 'https://openalex.org/W1571290156', 'https://openalex.org/W153215394'], 'abstract_inverted_index': {'The': [0], 'role': [1, 86], 'of': [2, 38, 49, 79, 87, 121, 126, 130, 132, 163], 'sodium': [3], 'channel': [4, 33, 50, 122], 'closed-state': [5, 19, 92, 110], 'fast': [6, 20, 93, 111, 135, 145], 'inactivation': [7, 146], 'in': [8, 30, 46, 55, 91], 'membrane': [9], 'excitability': [10], 'is': [11], 'not': [12], 'well': [13], 'understood.': [14], 'We': [15], 'compared': [16], 'open-': [17, 108], 'and': [18, 22, 42, 104, 124], 'inactivation,': [21], 'the': [23, 47, 77, 85, 100, 155], 'gating': [24, 73, 101, 127], 'charge': [25, 40, 74, 105], 'immobilized': [26, 106], 'during': [27, 107], 'these': [28], 'transitions,': [29], 'skeletal': [31, 56], 'muscle': [32, 57], 'hNaV1.4.': [34], 'A': [35], 'significant': [36], 'fraction': [37], 'total': [39], 'movement': [41, 78], 'its': [43], 'immobilization': [44], 'occurred': [45], 'absence': [48], 'opening.': [51], 'Simulated': [52], 'action': [53], 'potentials': [54], 'fibers': [58], 'were': [59], 'attenuated': [60], 'when': [61], 'pre-conditioned': [62], 'by': [63], 'sub-threshold': [64], 'depolarization.': [65], 'Anthopleurin': [66, 95], 'A,': [67], 'a': [68], 'site-3': [69], 'toxin': [70, 115], 'that': [71, 140], 'inhibits': [72], 'associated': [75], 'with': [76], 'DIVS4,': [80], 'was': [81], 'used': [82], 'to': [83, 154], 'assess': [84], 'this': [88], 'voltage': [89], 'sensor': [90], 'inactivation.': [94, 112, 136], 'elicited': [96], 'opposing': [97], 'effects': [98, 118], 'on': [99, 119], 'mode,': [102], 'kinetics': [103], 'versus': [109, 149], 'This': [113], 'same': [114], 'produced': [116], 'identical': [117], 'recovery': [120], 'availability': [123], 'remobilization': [125], 'charge,': [128], 'irrespective': [129], 'route': [131], 'entry': [133, 143], 'into': [134, 144], 'Our': [137], 'findings': [138], 'suggest': [139], 'depolarization': [141], 'promoting': [142], 'from': [147], 'open': [148], 'closed': [150], 'states': [151], 'provides': [152], 'access': [153], 'IFMT': [156], 'receptor': [157], 'via': [158], 'different': [159], 'rate-limiting': [160], 'conformational': [161], 'translocations': [162], 'DIVS4.': [164]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113366653', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-08-31T23:11:07.386985', 'created_date': '2016-06-24'}