Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2008009080', 'doi': 'https://doi.org/10.1128/aac.35.10.2026', 'title': 'In vivo activities of newer rifamycin analogs against Mycobacterium avium infection', 'display_name': 'In vivo activities of newer rifamycin analogs against Mycobacterium avium infection', 'publication_year': 1991, 'publication_date': '1991-10-01', 'ids': {'openalex': 'https://openalex.org/W2008009080', 'doi': 'https://doi.org/10.1128/aac.35.10.2026', 'mag': '2008009080', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1662021', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/245319'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.35.10.2026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/aac.35.10.2026', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035282198', 'display_name': 'S P Klemens', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114695', 'display_name': 'Syracuse VA Medical Center', 'ror': 'https://ror.org/0332k3m42', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210094901', 'https://openalex.org/I4210114695']}, {'id': 'https://openalex.org/I20388574', 'display_name': 'SUNY Upstate Medical University', 'ror': 'https://ror.org/040kfrw16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I20388574']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S P Klemens', 'raw_affiliation_strings': ['Veterans Affairs Medical Center, Syracuse, New York 13210.'], 'affiliations': [{'raw_affiliation_string': 'Veterans Affairs Medical Center, Syracuse, New York 13210.', 'institution_ids': ['https://openalex.org/I4210114695', 'https://openalex.org/I20388574']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053265147', 'display_name': 'Michael H. Cynamon', 'orcid': 'https://orcid.org/0000-0003-3796-9475'}, 'institutions': [{'id': 'https://openalex.org/I4210114695', 'display_name': 'Syracuse VA Medical Center', 'ror': 'https://ror.org/0332k3m42', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210094901', 'https://openalex.org/I4210114695']}, {'id': 'https://openalex.org/I20388574', 'display_name': 'SUNY Upstate Medical University', 'ror': 'https://ror.org/040kfrw16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I20388574']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M H Cynamon', 'raw_affiliation_strings': ['Veterans Affairs Medical Center, Syracuse, New York 13210.'], 'affiliations': [{'raw_affiliation_string': 'Veterans Affairs Medical Center, Syracuse, New York 13210.', 'institution_ids': ['https://openalex.org/I4210114695', 'https://openalex.org/I20388574']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.135, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.736495, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '35', 'issue': '10', 'first_page': '2026', 'last_page': '2030'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rifapentine', 'display_name': 'Rifapentine', 'score': 0.99442685}, {'id': 'https://openalex.org/keywords/rifabutin', 'display_name': 'Rifabutin', 'score': 0.97499406}, {'id': 'https://openalex.org/keywords/rifamycin', 'display_name': 'Rifamycin', 'score': 0.9690466}, {'id': 'https://openalex.org/keywords/clofazimine', 'display_name': 'Clofazimine', 'score': 0.6707399}, {'id': 'https://openalex.org/keywords/ethionamide', 'display_name': 'Ethionamide', 'score': 0.41483542}], 'concepts': [{'id': 'https://openalex.org/C2776991065', 'wikidata': 'https://www.wikidata.org/wiki/Q3935297', 'display_name': 'Rifapentine', 'level': 5, 'score': 0.99442685}, {'id': 'https://openalex.org/C2780867798', 'wikidata': 'https://www.wikidata.org/wiki/Q1135705', 'display_name': 'Rifabutin', 'level': 4, 'score': 0.97499406}, {'id': 'https://openalex.org/C2776306059', 'wikidata': 'https://www.wikidata.org/wiki/Q388565', 'display_name': 'Rifamycin', 'level': 3, 'score': 0.9690466}, {'id': 'https://openalex.org/C2776228421', 'wikidata': 'https://www.wikidata.org/wiki/Q412318', 'display_name': 'Ethambutol', 'level': 4, 'score': 0.7651558}, {'id': 'https://openalex.org/C2776297342', 'wikidata': 'https://www.wikidata.org/wiki/Q418611', 'display_name': 'Clofazimine', 'level': 3, 'score': 0.6707399}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5355807}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.5328969}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.5327176}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4527663}, {'id': 'https://openalex.org/C2776967927', 'wikidata': 'https://www.wikidata.org/wiki/Q423169', 'display_name': 'Isoniazid', 'level': 3, 'score': 0.44669977}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.42553693}, {'id': 'https://openalex.org/C2776448121', 'wikidata': 'https://www.wikidata.org/wiki/Q414767', 'display_name': 'Ethionamide', 'level': 5, 'score': 0.41483542}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40667006}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2853391}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.26230562}, {'id': 'https://openalex.org/C2778607973', 'wikidata': 'https://www.wikidata.org/wiki/Q422652', 'display_name': 'Rifampicin', 'level': 3, 'score': 0.21760482}, {'id': 'https://openalex.org/C2776962512', 'wikidata': 'https://www.wikidata.org/wiki/Q118551', 'display_name': 'Clarithromycin', 'level': 3, 'score': 0.188923}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16219163}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.14398313}, {'id': 'https://openalex.org/C2779806340', 'wikidata': 'https://www.wikidata.org/wiki/Q4254929', 'display_name': 'Latent tuberculosis', 'level': 4, 'score': 0.09028107}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.06682828}, {'id': 'https://openalex.org/C2780695269', 'wikidata': 'https://www.wikidata.org/wiki/Q36956', 'display_name': 'Leprosy', 'level': 2, 'score': 0.05933982}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015270', 'descriptor_name': 'Mycobacterium avium-intracellulare Infection', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012294', 'descriptor_name': 'Rifamycins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003470', 'descriptor_name': 'Culture Media', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015270', 'descriptor_name': 'Mycobacterium avium-intracellulare Infection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015270', 'descriptor_name': 'Mycobacterium avium-intracellulare Infection', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D017828', 'descriptor_name': 'Rifabutin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012293', 'descriptor_name': 'Rifampin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012293', 'descriptor_name': 'Rifampin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D012293', 'descriptor_name': 'Rifampin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012294', 'descriptor_name': 'Rifamycins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012294', 'descriptor_name': 'Rifamycins', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D012294', 'descriptor_name': 'Rifamycins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.35.10.2026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc245319', 'pdf_url': 'https://europepmc.org/articles/pmc245319?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245319', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1662021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.35.10.2026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1672233673', 'https://openalex.org/W1942379658', 'https://openalex.org/W1967344273', 'https://openalex.org/W1976081868', 'https://openalex.org/W2001583994', 'https://openalex.org/W2008916602', 'https://openalex.org/W2010263785', 'https://openalex.org/W2013639100', 'https://openalex.org/W2013773040', 'https://openalex.org/W2016969469', 'https://openalex.org/W2029013724', 'https://openalex.org/W2031906402', 'https://openalex.org/W2045673731', 'https://openalex.org/W2051284413', 'https://openalex.org/W2063980405', 'https://openalex.org/W2064177281', 'https://openalex.org/W2069821538', 'https://openalex.org/W2147285654', 'https://openalex.org/W2150100335', 'https://openalex.org/W2225520533', 'https://openalex.org/W563662596'], 'related_works': ['https://openalex.org/W4300580349', 'https://openalex.org/W3152826736', 'https://openalex.org/W2184746800', 'https://openalex.org/W2045673731', 'https://openalex.org/W2022991775', 'https://openalex.org/W2011662622', 'https://openalex.org/W2008009080', 'https://openalex.org/W1968887086', 'https://openalex.org/W1968675527', 'https://openalex.org/W1602670054'], 'abstract_inverted_index': {'The': [0, 56, 86, 113, 134, 151], 'comparative': [1], 'activities': [2], 'of': [3, 10, 29, 40, 58, 88, 115, 136, 153, 172], 'newer': [4], 'rifamycin': [5], 'analogs': [6], 'and': [7, 35, 47, 63, 90, 120, 141, 155], 'the': [8, 23, 84, 111, 148, 170], 'activity': [9, 74, 101, 127, 146], 'rifabutin': [11, 64, 79], 'or': [12], 'rifapentine': [13, 36, 91, 106, 121, 132, 142, 156], 'in': [14, 22, 69, 73, 83, 96, 100, 110, 123, 126, 144, 147], 'combination': [15, 57, 87, 114, 135, 152], 'with': [16, 78, 105, 129], 'other': [17], 'antimycobacterial': [18], 'agents': [19], 'was': [20], 'evaluated': [21, 168], 'beige': [24], '(C57BL/6J;': [25], 'bgj/bgj)': [26], 'mouse': [27, 149], 'model': [28], 'disseminated': [30], 'Mycobacterium': [31], 'avium': [32, 178], 'infection.': [33], 'Rifabutin': [34], 'at': [37, 50, 60, 65, 92, 117, 138], '20': [38, 51, 66, 93, 139], 'mg/kg': [39, 52, 62, 67, 94, 119, 140], 'body': [41], 'weight': [42], 'had': [43], 'comparable': [44], 'activities.': [45], 'P/DEA': [46], 'CGP': [48], '7040': [49], 'were': [53], 'less': [54], 'active.': [55], 'ethambutol': [59, 89], '125': [61, 118], 'resulted': [68, 95, 122, 143], 'a': [70, 97, 124], 'slight': [71], 'increase': [72, 99], 'beyond': [75, 102], 'that': [76, 103, 130, 165], 'seen': [77, 104], 'alone': [80, 107], 'against': [81, 108], 'organisms': [82, 109], 'spleens.': [85], 'modest': [98], 'lungs.': [112], 'ethionamide': [116], 'decrease': [125], 'compared': [128], 'for': [131, 169], 'alone.': [133], 'clofazimine': [137, 154], 'increased': [145], 'model.': [150], '(or': [157], 'rifabutin)': [158], 'appears': [159], 'to': [160, 176], 'be': [161, 167], 'an': [162], 'attractive': [163], 'regimen': [164], 'should': [166], 'treatment': [171], 'human': [173], 'infections': [174], 'due': [175], 'M.': [177], 'complex.': [179]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2008009080', 'counts_by_year': [], 'updated_date': '2024-12-14T05:18:11.650088', 'created_date': '2016-06-24'}