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'abstract_inverted_index': {'<i>Background:</i>': [0], 'Advanced': [1], 'glycation': [2], 'end': [3], 'products': [4], '(AGEs)': [5], 'are': [6], 'formed': [7], 'by': [8], 'the': [9, 30, 54, 66, 70, 78, 83, 98, 128, 135, 156, 161, 194], 'reaction': [10, 139], 'of': [11, 16, 37, 56, 69, 124, 127, 155], 'sugars': [12], 'and': [13, 18, 21, 59, 82, 116, 141, 160, 170, 176, 191], 'NH<sub>2</sub>': [14], 'groups': [15], 'lysine': [17], 'arginine': [19], 'residues': [20], 'have': [22], 'been': [23], 'shown': [24], 'to': [25, 44, 53], 'accumulate': [26], 'in': [27, 47, 88, 193], 'tissues,': [28], 'including': [29], 'heart,': [31], 'with': [32, 39], 'normal': [33], 'ageing.': [34], 'The': [35], 'interaction': [36], 'AGEs': [38, 86], 'their': [40], 'receptors': [41, 131, 187], 'is': [42], 'known': [43, 72], 'cause': [45], 'changes': [46], 'cell': [48], 'function,': [49], 'leading,': [50], 'for': [51, 85, 158, 168, 174, 185], 'example,': [52], 'production': [55], 'pro-inflammatory': [57], 'cytokines': [58], 'free': [60], 'radicals.': [61], '<i>Objective:</i>': [62], 'This': [63, 179], 'study': [64, 180], 'investigated': [65], 'gene': [67, 125], 'expression': [68, 126], 'five': [71, 129], 'AGE': [73, 130, 186], 'receptors:': [74], 'AGE-R1,': [75], 'AGE-R2,': [76], 'AGE-R3,': [77], 'scavenger': [79, 162], 'receptor': [80, 84, 163], 'II,': [81, 164], '(RAGE)': [87], 'human': [89], 'heart': [90], 'tissue.': [91], '<i>Methods:</i>': [92], 'Tissue': [93], 'samples': [94], 'were': [95], 'taken': [96], 'from': [97, 102], 'right': [99], 'cardiac': [100], 'auricles': [101], 'three': [103], 'patient': [104], 'groups:': [105], 'children': [106], '(2.4': [107], '±': [108, 113, 120], '1.1': [109], 'years),': [110], 'adults': [111], '(45.3': [112], '0.8': [114], 'years)': [115], 'elderly': [117], 'subjects': [118], '(76.4': [119], '0.4': [121], 'years).': [122], 'Analysis': [123], 'was': [132], 'performed': [133], 'using': [134], 'reverse': [136], 'transcription-polymerase': [137], 'chain': [138], '(RT-PCR)': [140], '18S': [142], 'mRNA': [143], 'levels': [144], 'as': [145, 189], 'loading': [146], 'controls.': [147], '<i>Results:</i>': [148], 'Our': [149], 'results': [150], 'show': [151], 'an': [152], 'age-dependent': [153], 'upregulation': [154], 'genes': [157], 'AGE-R3': [159, 190], 'but': [165], 'a': [166, 182], 'downregulation': [167], 'RAGE': [169, 192], 'no': [171], 'significant': [172], 'differences': [173], 'AGE-R1': [175], 'AGE-R2.': [177], '<i>Conclusion:</i>': [178], 'supports': [181], 'pathophysiological': [183], 'function': [184], 'such': [188], 'ageing': [195], 'heart.': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2007723032', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-07T22:41:04.567870', 'created_date': '2016-06-24'}