Publication Information

{'id': 'https://openalex.org/W2005279807', 'doi': 'https://doi.org/10.1074/jbc.m609343200', 'title': 'Fast and Selective Ammonia Transport by Aquaporin-8', 'display_name': 'Fast and Selective Ammonia Transport by Aquaporin-8', 'publication_year': 2006, 'publication_date': '2006-12-22', 'ids': {'openalex': 'https://openalex.org/W2005279807', 'doi': 'https://doi.org/10.1074/jbc.m609343200', 'mag': '2005279807', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17189259', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3056221'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609343200', 'pdf_url': 'http://www.jbc.org/article/S0021925820688238/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820688238/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046446817', 'display_name': 'Sapar M. Saparov', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121883995', 'display_name': 'Johannes Kepler University of Linz', 'ror': 'https://ror.org/052r2xn60', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I121883995']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Sapar M. Saparov', 'raw_affiliation_strings': ['Institut für Biophysik, Kepler Universität Linz, Altenbergerstrasse 69, A-4040 Linz, Austria.'], 'affiliations': [{'raw_affiliation_string': 'Institut für Biophysik, Kepler Universität Linz, Altenbergerstrasse 69, A-4040 Linz, Austria.', 'institution_ids': ['https://openalex.org/I121883995']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100398795', 'display_name': 'Kun Liu', 'orcid': 'https://orcid.org/0000-0003-0542-1739'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kun Liu', 'raw_affiliation_strings': ['†Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710;'], 'affiliations': [{'raw_affiliation_string': '†Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710;', 'institution_ids': ['https://openalex.org/I170897317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017989879', 'display_name': 'Peter Agre', 'orcid': 'https://orcid.org/0000-0002-9581-890X'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Agre', 'raw_affiliation_strings': ['†Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710;'], 'affiliations': [{'raw_affiliation_string': '†Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710;', 'institution_ids': ['https://openalex.org/I170897317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009442181', 'display_name': 'Peter Pohl', 'orcid': 'https://orcid.org/0000-0002-1792-2314'}, 'institutions': [{'id': 'https://openalex.org/I121883995', 'display_name': 'Johannes Kepler University of Linz', 'ror': 'https://ror.org/052r2xn60', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I121883995']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Peter Pohl', 'raw_affiliation_strings': ['Institut fuör Biophysik, Kepler Universitaöt Linz, Altenbergerstrasse 69, A-4040 Linz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institut fuör Biophysik, Kepler Universitaöt Linz, Altenbergerstrasse 69, A-4040 Linz, Austria', 'institution_ids': ['https://openalex.org/I121883995']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.43, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 192, 'citation_normalized_percentile': {'value': 0.927411, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '282', 'issue': '8', 'first_page': '5296', 'last_page': '5301'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12074', 'display_name': 'Membrane-based Ion Separation Techniques', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11582', 'display_name': 'Nanopore and Nanochannel Transport Studies', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776382133', 'wikidata': 'https://www.wikidata.org/wiki/Q4087', 'display_name': 'Ammonia', 'level': 2, 'score': 0.71541816}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.58418405}, {'id': 'https://openalex.org/C154280991', 'wikidata': 'https://www.wikidata.org/wiki/Q623090', 'display_name': 'Aquaporin', 'level': 2, 'score': 0.48155788}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.42751622}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38003114}, {'id': 'https://openalex.org/C107872376', 'wikidata': 'https://www.wikidata.org/wiki/Q321355', 'display_name': 'Environmental chemistry', 'level': 1, 'score': 0.32270816}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19095328}], 'mesh': [{'descriptor_ui': 'D000641', 'descriptor_name': 'Ammonia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008051', 'descriptor_name': 'Lipid Bilayers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011522', 'descriptor_name': 'Protons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000641', 'descriptor_name': 'Ammonia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000641', 'descriptor_name': 'Ammonia', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017136', 'descriptor_name': 'Ion Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017136', 'descriptor_name': 'Ion Transport', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008051', 'descriptor_name': 'Lipid Bilayers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008051', 'descriptor_name': 'Lipid Bilayers', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609343200', 'pdf_url': 'http://www.jbc.org/article/S0021925820688238/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3056221', 'pdf_url': 'https://europepmc.org/articles/pmc3056221?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056221', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17189259', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609343200', 'pdf_url': 'http://www.jbc.org/article/S0021925820688238/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1580434367', 'https://openalex.org/W1969355717', 'https://openalex.org/W1973332969', 'https://openalex.org/W1974735014', 'https://openalex.org/W1975902868', 'https://openalex.org/W1983020085', 'https://openalex.org/W1985880664', 'https://openalex.org/W1985938141', 'https://openalex.org/W1995087505', 'https://openalex.org/W1998548799', 'https://openalex.org/W1999068193', 'https://openalex.org/W2001738942', 'https://openalex.org/W2003879331', 'https://openalex.org/W2009703891', 'https://openalex.org/W2024754660', 'https://openalex.org/W2027153868', 'https://openalex.org/W2028556330', 'https://openalex.org/W2031272029', 'https://openalex.org/W2034089135', 'https://openalex.org/W2036237297', 'https://openalex.org/W2042717435', 'https://openalex.org/W2051457709', 'https://openalex.org/W2053977404', 'https://openalex.org/W2056498261', 'https://openalex.org/W2062249432', 'https://openalex.org/W2071897480', 'https://openalex.org/W2072994989', 'https://openalex.org/W2076156264', 'https://openalex.org/W2078647430', 'https://openalex.org/W2080913586', 'https://openalex.org/W2085397786', 'https://openalex.org/W2095251996', 'https://openalex.org/W2096526128', 'https://openalex.org/W2104129019', 'https://openalex.org/W2110197710', 'https://openalex.org/W2119861313', 'https://openalex.org/W2120896104', 'https://openalex.org/W2122557223', 'https://openalex.org/W2126747686', 'https://openalex.org/W2144737544', 'https://openalex.org/W2151136485', 'https://openalex.org/W2160924308', 'https://openalex.org/W2168421316', 'https://openalex.org/W2170843321', 'https://openalex.org/W2172111004', 'https://openalex.org/W2281945593', 'https://openalex.org/W2406440068'], 'related_works': ['https://openalex.org/W812052363', 'https://openalex.org/W3142543453', 'https://openalex.org/W2944132920', 'https://openalex.org/W2591905584', 'https://openalex.org/W2467703106', 'https://openalex.org/W2154009044', 'https://openalex.org/W2113681449', 'https://openalex.org/W2046014422', 'https://openalex.org/W2032067567', 'https://openalex.org/W202868969'], 'abstract_inverted_index': {'The': [0, 57, 87, 175, 232, 262, 416, 449, 945, 1163, 1374, 1481, 1663, 1710, 1888, 1902, 1960, 1979, 2287, 2486, 2641, 2652, 2818, 3032, 3083, 3380, 4142, 4291, 4545, 4927], 'transport': [1, 50, 167, 176, 225, 342, 385, 464, 627, 739, 831, 843, 869, 1104, 1168, 1184, 1221, 1235, 1279, 1297, 2789, 2915, 3050, 3512, 3959, 3979, 4196, 4378, 4547, 4634, 4740, 4771], 'of': [2, 12, 29, 51, 71, 81, 93, 173, 177, 187, 204, 226, 246, 256, 268, 348, 408, 451, 473, 613, 632, 718, 835, 838, 861, 865, 875, 882, 952, 978, 1001, 1015, 1053, 1094, 1255, 1303, 1308, 1394, 1477, 1484, 1489, 1524, 1556, 1563, 1601, 1611, 1673, 1741, 1763, 1802, 1814, 1823, 1830, 1838, 1866, 1899, 1911, 1923, 1950, 1985, 2007, 2030, 2054, 2065, 2088, 2176, 2203, 2205, 2225, 2296, 2301, 2313, 2418, 2461, 2468, 2493, 2498, 2508, 2515, 2547, 2610, 2627, 2660, 2700, 2745, 2777, 2781, 2795, 2807, 2820, 2834, 2916, 2986, 3068, 3079, 3085, 3145, 3174, 3189, 3194, 3225, 3245, 3259, 3262, 3283, 3307, 3322, 3326, 3382, 3397, 3422, 3438, 3446, 3452, 3463, 3513, 3526, 3583, 3651, 3660, 3802, 3810, 3854, 3860, 3873, 3915, 3939, 3977, 4002, 4126, 4154, 4185, 4209, 4238, 4253, 4279, 4294, 4316, 4342, 4379, 4391, 4462, 4540, 4548, 4565, 4605, 4609, 4623, 4734, 4868, 4882, 4895, 4934, 4936, 4976], 'ammonia/ammonium': [3, 178], 'is': [4, 27, 41, 124, 179, 202, 216, 299, 454, 623, 818, 850, 969, 1010, 1044, 1109, 1115, 1282, 1770, 1799, 2056, 2060, 2198, 2324, 2538, 2565, 2629, 2649, 2691, 2710, 2997, 3343, 3641, 3781, 3804, 3852, 4175, 4180, 4298, 4321, 4373, 4396, 4531, 4616, 4941], 'fundamental': [5, 180], 'to': [6, 22, 46, 117, 156, 181, 197, 221, 292, 331, 379, 522, 528, 537, 601, 609, 732, 746, 820, 847, 959, 964, 993, 1088, 1125, 1217, 1232, 1592, 1722, 1766, 1772, 1842, 1928, 1937, 1967, 2034, 2230, 2233, 2357, 2540, 2543, 2559, 2631, 2842, 2860, 2934, 2937, 2992, 2999, 3023, 3038, 3094, 3183, 3216, 3235, 3359, 3456, 3632, 3643, 3669, 3875, 4134, 4199, 4286, 4412, 4775, 4899, 4943, 4990], 'nitrogen': [7, 182], 'metabolism': [8, 183], 'in': [9, 113, 184, 288, 518, 520, 603, 616, 625, 628, 639, 741, 772, 786, 832, 873, 915, 1019, 1063, 1118, 1315, 1372, 1597, 1686, 1821, 1974, 1983, 1999, 2099, 2144, 2209, 2240, 2353, 2478, 2482, 2551, 2587, 2692, 2711, 2755, 2968, 3019, 3034, 3171, 3179, 3186, 3205, 3272, 3336, 3405, 3529, 3567, 3599, 3923, 3933, 4011, 4068, 4122, 4191, 4349, 4388, 4399, 4901, 4974], 'all': [10, 185, 2095, 2226, 2509], 'forms': [11, 186], 'life.': [13, 188], 'So': [14, 189], 'far,': [15, 190], 'no': [16, 191, 779], 'clear': [17, 192], 'picture': [18, 193], 'has': [19, 194, 1171, 4408, 4542, 4777], 'emerged': [20, 195], 'as': [21, 196, 424, 681, 824, 1321, 1389, 2142, 2238, 2585, 2753, 2857, 2966, 3319, 3334, 3403, 3869, 3871, 3931, 4246, 4248, 4271, 4635, 4736, 4738], 'whether': [23, 198, 1219, 1228, 4945], 'a': [24, 54, 79, 144, 199, 229, 254, 319, 507, 948, 960, 1007, 1129, 1380, 1485, 1554, 1594, 1602, 1668, 1848, 1880, 1892, 1968, 1971, 1986, 1990, 1994, 2040, 2454, 2479, 2499, 2698, 2719, 2927, 2938, 3062, 3184, 3320, 3623, 3908, 3925, 4108, 4118, 4305, 4375, 4384, 4460, 4763, 4931, 4950, 4962, 4971], 'protein': [25, 61, 200, 236, 410, 622, 646, 737, 1369, 1376, 2560, 2612, 2647, 3254, 3441, 3785, 4131, 4302, 4345], 'channel': [26, 60, 89, 132, 201, 235, 264, 307, 427, 3328, 3376, 3402, 3919, 3948, 4006, 4070, 4151, 4323, 4406, 4454, 4535], 'capable': [28, 203], 'transporting': [30, 205, 4764], 'exclusively': [31, 206], 'neutral': [32, 207, 2917, 3383, 3515, 4937, 4965], 'NH3': [33, 52, 208, 227, 626, 642, 830, 868, 997, 1092, 1103, 1181, 1234, 1275, 1963, 2047, 2918, 2929, 3049, 3143, 3212, 3223, 3246, 3346, 3516, 3587, 3850, 3863, 3928, 3964, 4288, 4549, 4735, 4861, 4966, 4987], 'while': [34, 209], 'excluding': [35, 210], 'H+': [36, 74, 211, 249, 4241, 4568, 4607, 4871], 'and': [37, 68, 109, 149, 212, 243, 284, 324, 382, 572, 743, 795, 857, 877, 917, 955, 985, 988, 998, 1017, 1065, 1121, 1182, 1269, 1306, 1319, 1353, 1474, 1500, 1519, 1544, 1733, 1746, 1787, 1805, 1970, 1993, 2147, 2174, 2213, 2304, 2348, 2512, 2526, 2604, 2615, 2767, 2773, 2971, 2979, 2989, 3014, 3042, 3081, 3147, 3154, 3412, 3418, 3433, 3595, 3634, 3700, 3723, 4240, 4261, 4263, 4273, 4327, 4346, 4451, 4559, 4697, 4838, 4938], 'NH+4.': [38, 213, 3787], 'Our': [39, 214], 'research': [40, 215], 'the': [42, 48, 69, 118, 130, 151, 157, 170, 217, 223, 244, 293, 305, 326, 332, 345, 409, 470, 514, 611, 621, 633, 645, 736, 747, 836, 853, 858, 866, 879, 883, 972, 975, 1002, 1020, 1051, 1089, 1095, 1098, 1110, 1224, 1252, 1300, 1358, 1364, 1392, 1445, 1560, 1598, 1607, 1612, 1687, 1714, 1719, 1723, 1737, 1742, 1747, 1752, 1760, 1800, 1817, 1839, 1843, 1860, 1867, 1874, 1909, 1912, 1938, 1942, 1947, 1951, 1957, 1975, 2000, 2004, 2008, 2031, 2035, 2049, 2051, 2063, 2077, 2085, 2100, 2177, 2199, 2206, 2220, 2223, 2294, 2311, 2316, 2320, 2358, 2416, 2494, 2504, 2513, 2544, 2552, 2556, 2573, 2579, 2607, 2611, 2616, 2693, 2746, 2770, 2774, 2796, 2803, 2831, 2843, 2845, 2866, 2942, 2982, 2990, 2993, 3011, 3015, 3024, 3056, 3075, 3096, 3165, 3172, 3195, 3201, 3210, 3222, 3226, 3273, 3281, 3299, 3305, 3308, 3312, 3344, 3373, 3398, 3415, 3419, 3439, 3443, 3464, 3506, 3514, 3522, 3530, 3563, 3568, 3584, 3589, 3597, 3600, 3639, 3648, 3658, 3784, 3807, 3816, 3848, 3858, 3862, 3883, 3916, 3947, 3974, 3989, 4000, 4005, 4062, 4069, 4124, 4127, 4145, 4183, 4206, 4243, 4276, 4284, 4295, 4300, 4313, 4317, 4322, 4335, 4339, 4343, 4347, 4389, 4392, 4532, 4538, 4551, 4601, 4620, 4640, 4669, 4730, 4883, 4888, 4892, 4896, 4985, 4999], 'first': [43, 218, 1411, 4533], 'stoichiometric': [44, 219, 4932], 'study': [45, 220, 4121, 4951], 'show': [47, 222], 'selective': [49, 224, 383, 1991], 'by': [53, 77, 100, 142, 228, 252, 275, 317, 1012, 1169, 1243, 1263, 1280, 1351, 1366, 1379, 1391, 1401, 1415, 1453, 1536, 1758, 1774, 1811, 1847, 1879, 2039, 2062, 2083, 2339, 2555, 2578, 2786, 2920, 3028, 3051, 3160, 3248, 3266, 3349, 3388, 3395, 3778, 4194, 4235, 4250, 4334, 4459, 4554, 4879], 'membrane': [55, 119, 230, 294, 540, 1022, 1359, 1689, 1844, 1952, 1977, 2009, 2036, 2052, 2102, 2359, 2574, 3025, 3253, 3275, 3640, 3649, 3662, 4245, 4553], 'channel.': [56, 231], 'purified': [58, 233, 1245, 1320, 1468, 2336, 3440], 'water': [59, 90, 234, 265, 384, 463, 541, 1264, 1291, 1679, 1803, 2333, 2458, 2488, 3432, 3953, 3967, 3978, 4003, 4326], 'aquaporin-8': [62, 237, 452], 'was': [63, 75, 98, 140, 238, 250, 273, 315, 459, 511, 526, 599, 607, 638, 871, 924, 1056, 1177, 1214, 1261, 1313, 1361, 1370, 1377, 1385, 1448, 1503, 1665, 1681, 1756, 1845, 1877, 1891, 1926, 1935, 1953, 1981, 2037, 2643, 2664, 2784, 2869, 2922, 2932, 3008, 3070, 3091, 3162, 3168, 3256, 3264, 3289, 3301, 3315, 3357, 3985, 4132, 4456, 4863, 4872], 'reconstituted': [64, 106, 239, 281, 724, 1412, 2345, 2813, 3043, 3229, 3694, 4281, 4301, 4344], 'into': [65, 240, 1247, 1405, 1413, 1505, 1547, 1859, 2093, 3073], 'planar': [66, 107, 241, 282, 1248, 1595, 1868, 2346, 2412, 3012, 3044, 3227, 3695], 'bilayers,': [67, 108, 242, 283, 3156], 'exclusion': [70, 245, 4539], 'NH+4': [72, 247, 637, 680, 1183, 1220, 1972, 2055, 2788, 2827, 2939, 3005, 3020, 3035, 3057, 3180, 3269, 3524, 3574, 4541, 4566, 4606, 4633, 4869], 'or': [73, 248, 781, 1227, 2811, 3458, 4137, 4632, 4668, 4870], 'established': [76, 99, 251, 274], 'ensuring': [78, 253], 'lack': [80, 255, 2064, 3697], 'current': [82, 257, 1876, 2804], 'under': [83, 258, 455], 'voltage': [84, 259, 1871, 2805], 'clamp': [85, 260, 674, 1872, 1882], 'conditions.': [86, 261], 'single': [88, 131, 263, 306, 2500, 3327, 3375, 3918, 3997, 4150], 'permeability': [91, 134, 160, 266, 309, 335, 542, 731, 1009, 1093, 1289, 1292, 2496, 3224, 3330, 3347, 3525, 3650, 3920, 4153], 'coefficient': [92, 267, 2497, 3377], '1.2': [94, 269], '×': [95, 136, 270, 311, 1542, 2636, 2704, 3102, 3363, 3795, 3812, 4611], '10–14': [96, 137, 271, 312, 2637, 2705, 3364], 'cm3/subunit/s': [97, 272], 'imposing': [101, 276, 2340], 'an': [102, 277, 425, 523, 715, 2341, 3267, 4350, 4563], 'osmotic': [103, 278, 524, 986, 1678, 1743, 2332, 2342, 2457], 'gradient': [104, 148, 279, 323, 525, 1973, 2343, 3007, 3060, 3626], 'across': [105, 280, 2344, 3010, 4550], 'resulting': [110, 152, 285, 327, 1961, 2350, 3016], 'minute': [111, 286, 2351], 'changes': [112, 287, 2352, 3018, 4187, 4211], 'ionic': [114, 289, 2354], 'concentration': [115, 147, 153, 290, 322, 328, 1471, 1555, 1712, 1761, 1804, 1945, 2175, 2355, 2799, 3006, 3021, 3059, 3181, 3270, 3298, 3851, 3859], 'close': [116, 291, 2356, 3022], 'surface': [120, 295, 2360], 'were': [121, 296, 575, 726, 911, 1410, 1534, 1545, 1567, 1590, 1809, 1825, 1857, 1906, 2840, 3026, 3150], 'detected.': [122, 297], 'It': [123, 298, 817, 1043, 1502, 3969, 4395, 4875], 'more': [125, 300], 'than': [126, 129, 301, 304, 536, 1387, 1955, 2871, 3372, 3857, 3952, 3966, 4010], '2-fold': [127, 302, 3370], 'smaller': [128, 303, 3856], 'ammonia': [133, 166, 308, 341, 604, 790, 793, 797, 1167, 1270, 1278, 1288, 1296, 3080, 3384, 3434, 3790, 4111, 4140, 4621], '(2.7': [135, 310, 3360], 'cm3/subunit/s)': [138, 313], 'that': [139, 163, 314, 338, 461, 513, 620, 677, 735, 947, 974, 1287, 1295, 2091, 2293, 2319, 2414, 2646, 2824, 3428, 3629, 3638, 3783, 3872, 3973, 3988, 4064, 4182, 4299, 4377, 4766, 4930], 'derived': [141, 316, 1682, 2566, 3986], 'establishing': [143, 318], 'transmembrane': [145, 320, 1875, 1962, 2928, 3058, 3211, 3624], 'ammonium': [146, 321, 617, 740, 839, 842, 3329, 4671], 'measuring': [150, 325], 'increases': [154, 329, 1717], 'adjacent': [155, 330, 3037], 'membrane.': [158, 333], 'This': [159, 334, 849, 967, 2058, 3518, 4114], 'ratio': [161, 336, 1672], 'suggests': [162, 337], 'electrically': [164, 339, 1283], 'silent': [165, 340], 'may': [168, 343, 412, 465, 738, 1298, 3577, 3654, 3664, 3980, 4007, 4303, 4983], 'be': [169, 344, 466, 714, 965, 990, 1123, 1299, 2231, 2541, 2632, 3393, 3655, 3868, 3971, 3981, 4008, 4232, 4331, 4597, 4727, 4877], 'main': [171, 346, 1301], 'function': [172, 347, 450, 1302, 3321], 'AQP8.': [174, 349, 1304, 2791, 4769, 4958], 'Aquaporins': [350], '(AQPs)': [351], '2The': [352, 364], 'abbreviations': [353, 365], 'used': [354, 366, 4133], 'are:': [355, 367], 'AQP,': [356, 368], 'aquaporin;': [357, 369], 'MES,': [358, 370], '4-morpholineethanesulfonic': [359, 371], 'acid;': [360, 372], 'MOPS,': [361, 373], '4-morpholinepropanesulfonic': [362, 374], 'acid.': [363, 375], 'are': [376, 845, 1735, 2080, 2228, 2290, 2306, 2606, 2769, 2981, 3414, 3571, 3775, 3991, 4433], 'commonly': [377], 'believed': [378], 'mediate': [380], 'fast': [381], '(1King': [386], 'L.S.': [387], 'Kozono': [388, 1419, 1616, 2363, 3728], 'D.': [389, 479, 487, 546, 582, 692, 802, 929, 933, 1194, 1420, 1617, 2364, 3472, 3544, 3729, 4160, 4216, 4436, 4509, 4571, 4816], 'Agre': [390, 438, 758, 1332, 1423, 1620, 1646, 2367, 2393, 2881, 3475, 3732, 3758], 'P.': [391, 439, 481, 759, 1027, 1070, 1142, 1333, 1424, 1426, 1621, 1623, 1641, 1647, 1692, 2013, 2107, 2128, 2273, 2368, 2370, 2388, 2394, 2435, 2876, 2882, 2903, 2950, 3108, 3129, 3476, 3490, 3607, 3712, 3733, 3735, 3753, 3759, 3821, 3825, 4016, 4046, 4465, 4513, 4710], 'Nat.': [392], 'Rev.': [393, 1577, 3480, 4048], 'Mol.': [394], 'Cell': [395], 'Biol.': [396, 491, 550, 760, 936, 1148, 1334, 1428, 1625, 2372, 2904, 3491, 3713, 3737, 4515, 4682], '2004;': [397, 665, 3493, 3839, 4024, 4517, 4805, 4830, 4919], '5:': [398], '687-698Crossref': [399], 'PubMed': [400, 444, 501, 560, 591, 668, 705, 765, 904, 940, 1038, 1081, 1158, 1207, 1339, 1438, 1582, 1635, 1658, 1705, 2024, 2118, 2137, 2282, 2382, 2405, 2446, 2683, 2737, 2893, 2909, 2961, 3119, 3138, 3484, 3496, 3557, 3618, 3688, 3718, 3747, 3770, 3842, 3895, 4027, 4053, 4085, 4100, 4366, 4446, 4499, 4525, 4586, 4663, 4692, 4721, 4757, 4808, 4833, 4856, 4922], 'Scopus': [401, 445, 502, 561, 592, 669, 706, 813, 905, 941, 1039, 1082, 1159, 1208, 1439, 1583, 1636, 1659, 1706, 2025, 2119, 2138, 2283, 2383, 2406, 2447, 2684, 2738, 2894, 2910, 2962, 3120, 3139, 3485, 3497, 3558, 3619, 3689, 3719, 3748, 3771, 3843, 3896, 4028, 4054, 4086, 4101, 4171, 4227, 4367, 4447, 4500, 4526, 4587, 4664, 4693, 4722, 4758, 4809, 4834, 4857, 4923], '(739)': [402], 'Google': [403, 447, 504, 563, 594, 671, 708, 766, 815, 907, 943, 1041, 1084, 1161, 1210, 1340, 1441, 1585, 1638, 1661, 1708, 2027, 2121, 2140, 2285, 2385, 2408, 2449, 2686, 2740, 2896, 2912, 2964, 3122, 3141, 3487, 3499, 3560, 3621, 3691, 3721, 3750, 3773, 3845, 3898, 4030, 4056, 4088, 4103, 4173, 4229, 4369, 4424, 4449, 4502, 4528, 4589, 4666, 4695, 4724, 4760, 4811, 4836, 4859, 4925], 'Scholar).': [404, 448, 505, 564, 595, 672, 709, 767, 816, 908, 944, 1042, 1085, 1162, 1341, 1442, 1586, 1662, 1709, 1797, 2028, 2286, 2409, 2536, 2687, 2741, 2913, 3142, 3561, 3692, 3846, 3899, 4057, 4104, 4370, 4529, 4590, 4926], 'However,': [405, 768, 3562, 4178, 4865], 'some': [406], 'members': [407, 881, 3462], 'family': [411, 885, 3466], 'have': [413, 1239, 3426, 3906, 4954], 'other': [414, 2260], 'functions.': [415], 'intracellular': [417, 1119, 4268], 'acid-sensing': [418], 'aquaporin-6': [419], '(AQP6),': [420], 'for': [421, 469, 852, 1049, 1100, 1166, 1527, 2046, 2236, 2662, 2750, 3099, 3152, 3292, 3378, 3815, 3880, 3927, 4110, 4144, 4312, 4325, 4536, 4567, 4594, 4637, 4729, 4743, 4780, 4957, 4964, 4996], 'example,': [422, 1050, 2663], 'serves': [423], 'anion': [426], '(2Yasui': [428], 'M.': [429, 489, 1571, 2672, 4477, 4700, 4747, 4749], 'Hazama': [430], 'A.': [431, 485, 1068, 1136, 1573, 1654, 1780, 2401, 2519, 2679, 2889, 3766, 3838, 4023, 4081, 4648, 4659, 4829], 'Kwon': [432, 3473], 'T.H.': [433, 3474], 'Nielsen': [434], 'S.': [435, 1653, 2400, 2678, 2888, 3468, 3765, 3837, 4022, 4080, 4469, 4473, 4475, 4658, 4791, 4818, 4828, 4905], 'Guggino': [436, 4470], 'W.B.': [437, 4471, 4680], 'Nature.': [440, 4096], '1999;': [441], '402:': [442], '184-187Crossref': [443], '(395)': [446], '(AQP8)': [453], 'dispute.': [456], 'First,': [457], 'it': [458, 510, 1114, 1213, 3509, 3592, 3602, 3780, 3984, 4179], 'suggested': [460, 676], 'AQP8-mediated': [462], 'particularly': [467], 'important': [468], 'rapid': [471, 515, 1233], 'expansion': [472], 'mitochondrial': [474], 'volume': [475, 516, 1744, 2776, 3421, 3943], '(3Calamita': [476], 'G.': [477, 757, 1331, 4039, 4091, 4702], 'Ferri': [478, 691, 1193, 3543], 'Gena': [480], 'Liquori': [482], 'G.E.': [483], 'Cavalier': [484], 'Thomas': [486], 'Svelto': [488], 'J.': [490, 549, 586, 700, 808, 899, 1032, 1072, 1147, 1202, 1427, 1624, 1698, 2017, 2111, 2130, 2275, 2371, 2440, 2954, 3112, 3131, 3470, 3552, 3611, 3681, 3736, 3890, 4166, 4222, 4441, 4514, 4581, 4681, 4715, 4753, 4793, 4797, 4849, 4907, 4911], 'Chem.': [492, 551, 1149, 1429, 1626, 2373, 3492, 3738, 4516, 4683, 4851], '2005;': [493, 588, 702, 901, 1204, 2906, 3554, 3715, 4660], '280:': [494], '17149-17153Abstract': [495], 'Full': [496, 498, 555, 557, 1153, 1155, 1433, 1435, 1630, 1632, 1702, 2021, 2115, 2134, 2279, 2377, 2379, 2958, 3116, 3135, 3615, 3685, 3742, 3744, 4520, 4522, 4687, 4689], 'Text': [497, 499, 556, 558, 1154, 1156, 1434, 1436, 1631, 1633, 1703, 2022, 2116, 2135, 2280, 2378, 2380, 2959, 3117, 3136, 3616, 3686, 3743, 3745, 4521, 4523, 4688, 4690], 'PDF': [500, 559, 1157, 1437, 1634, 1704, 2023, 2117, 2136, 2281, 2381, 2960, 3118, 3137, 3617, 3687, 3746, 4524, 4691], '(168)': [503], 'In': [506, 596, 1342, 1443, 1751, 2427, 3200, 3900, 3996, 4979], 'contrasting': [508], 'study,': [509], 'concluded': [512, 3782, 4929], 'equilibration': [517], 'mitochondria': [519, 4272], 'response': [521], 'due': [527], 'its': [529], 'small': [530, 784, 994, 3017], 'size': [531], '(high': [532], 'surface-to-volume': [533], 'ratio)': [534], 'rather': [535, 4397], 'AQP-mediated': [538], 'high': [539, 1013, 2308, 3870, 4428], '(4Yang': [543], 'B.': [544, 578, 658, 800, 2727, 4158, 4214, 4356, 4485, 4507, 4573], 'Zhao': [545, 581, 801, 4159, 4215], 'Verkman': [547, 583, 805, 2728, 4163, 4219, 4357, 4482], 'A.S.': [548, 584, 806, 2729, 4164, 4220, 4358, 4483], '2006;': [552, 762, 810, 937, 1078, 1336, 3892, 4050, 4168, 4224, 4443, 4583, 4718, 4754, 4853], '281:': [553], '16202-16206Abstract': [554], '(73)': [562], 'Moreover,': [565], 'only': [566, 782, 2462, 3190, 4155, 4292, 4411], 'mild': [567], 'phenotype': [568, 770, 962], 'differences': [569, 785], 'between': [570, 1989, 4338], 'wild-type': [571, 773], 'AQP8-deficient': [573], 'mice': [574, 777], 'found': [576, 1286, 2630, 4742], '(5Yang': [577], 'Song': [579], 'Y.': [580, 3829, 4708, 4799, 4844, 4848, 4913], 'Am.': [585, 807, 898, 4165, 4221, 4580, 4850], 'Physiol.': [587, 701, 809, 900, 1034, 1203, 2442, 3479, 3553, 3891, 4167, 4223, 4419, 4582, 4717], '288:': [589, 902], 'C1161-C1170Crossref': [590], '(158)': [593], 'addition,': [597], 'AQP8': [598, 606, 678, 719, 730, 775, 954, 1055, 1108, 1170, 1246, 1281, 1309, 1312, 1368, 1408, 1469, 2070, 2337, 2469, 2628, 2747, 2815, 2825, 2921, 3231, 3240, 3263, 3297, 3350, 3389, 3429, 3501, 3527, 3788, 3803, 3961, 4139, 4149, 4318, 4400, 4530, 4595, 4776, 4960, 4982], 'anticipated': [600, 2539], 'participate': [602], 'transport.': [605], 'able': [608], 'rescue': [610], 'growth': [612, 711], 'yeast': [614], 'defective': [615], 'uptake,': [618], 'suggesting': [619, 734, 1294, 4970], 'involved': [624], 'humans.': [629], 'Increased': [630], 'acidification': [631], 'oocyte': [634, 2721, 3532, 3569], 'medium': [635], 'containing': [636], 'accordance': [640], 'with': [641, 723, 1058, 1346, 1398, 1667, 1718, 1827, 1895, 1908, 2310, 2429, 2714, 2814, 3230, 3521, 3806, 3902, 3994, 4117, 4267, 4619, 4768], 'diffusion': [643, 2172, 2314, 2984, 3877], 'through': [644, 1223, 1783, 2315, 2335, 2522, 2790, 2941, 4242, 4383], '(6Jahn': [647], 'T.P.': [648, 686, 1188, 3538], 'Moller': [649, 687, 1189, 3539], 'A.L.B.': [650], 'Zeuthen': [651, 695, 1197, 3547], 'T.': [652, 696, 1198, 2725, 3548, 4354], 'Holm': [653], 'L.M.': [654, 684, 1186, 3536], 'Klaerke': [655, 693, 1195, 3545], 'D.A.': [656, 694, 1196, 3546], 'Mohsin': [657], 'Kuhlbrandt': [659], 'W.': [660, 4511], 'Schjoerring': [661, 689, 1191, 3541], 'J.K.': [662, 690, 1192, 3542, 4577], 'FEBS': [663], 'Lett.': [664, 4049], '574:': [666], '31-36Crossref': [667], '(262)': [670], 'Voltage': [673], 'experiments': [675, 722, 2431], 'conducts': [679], 'well': [682, 4247, 4737], '(7Holm': [683, 1185, 3535], 'Jahn': [685, 1187, 3537], 'A.L.': [688, 1190, 3540], 'Pflugers': [697, 1199, 3549], 'Arch.': [698, 1200, 3550, 3888], 'Eur.': [699, 1201, 3551, 3889], '450:': [703, 1205, 3555], '415-428Crossref': [704, 1206, 3556], '(207)': [707, 1209, 3559], 'Because': [710, 834, 3586, 3693, 3847, 3938], 'complementation': [712], 'could': [713], 'indirect': [716], 'effect': [717], 'expression,': [720], 'light-scattering': [721], 'vesicles': [725, 1120], 'conducted.': [727], 'They': [728, 3576], 'revealed': [729, 778, 1273, 1390], 'formamide,': [733], 'vivo': [742], 'physiologically': [744, 827], 'contribute': [745], 'acid-base': [748, 859, 4977], 'equilibrium': [749, 860, 2323], '(8Liu': [750, 1324], 'K.': [751, 895, 1325, 3673, 4479], 'Nagase': [752, 1326], 'H.': [753, 889, 1327, 1575], 'Huang': [754, 1328], 'C.G.': [755, 1329], 'Calamita': [756, 1330], 'Cell.': [761, 1335, 2905, 3714], '98:': [763, 1337, 1656, 2403, 2891, 3768], '153-161Crossref': [764, 1338], 'comparative': [769], 'studies': [771], 'versus': [774, 3055], 'null': [776], 'significant': [780, 828], 'very': [783, 2307, 2455, 3435, 3791], 'serum': [787], 'ammonia,': [788, 4328], 'colonic': [789], 'absorption,': [791], 'renal': [792], 'clearance,': [794], 'liver': [796], 'accumulation': [798], '(9Yang': [799, 4157, 4213], 'Solenov': [803, 4161, 4217], 'E.': [804, 1491, 4162, 4218, 4783], '291:': [811, 4169, 4225], 'C417-C423Crossref': [812, 4170, 4226], '(45)': [814, 4172, 4228], 'difficult': [819], 'interpret': [821], 'these': [822, 2451, 3644, 3698], 'results': [823, 2079, 2715, 4561], 'evidence': [825], 'against': [826, 1521], 'AQP8-facilitated': [829], 'mice.': [833], 'importance': [837], 'homeostasis,': [840], 'several': [841], 'pathways': [844, 870], 'likely': [846, 4181], 'exist.': [848], 'crucial': [851], 'urine': [854], 'pH': [855, 1459, 1969, 2076, 3598, 4186, 4210], 'adjustment': [856], 'body': [862], 'fluid.': [863], 'One': [864], 'alternative': [867], 'identified': [872], 'terms': [874, 1984], 'RhBG': [876, 4558], 'RhCG,': [878], 'non-erythroid': [880], 'Rh': [884, 956, 4556], '(10Nakhoul': [886], 'N.L.': [887], 'Dejong': [888], 'Abdulnour-Nakhoul': [890], 'S.M.': [891, 1418, 1615, 1643, 1694, 2362, 2390, 2878, 2899, 3708, 3727, 3755, 4014, 4033, 4489, 4491], 'Boulpaep': [892], 'E.L.': [893], 'Hering-Smith': [894], 'Hamm': [896], 'L.L.': [897], 'F170-F181Crossref': [903], '(78)': [906, 1584], 'These': [909], 'proteins': [910, 957, 1409, 3663], 'also': [912, 3578], 'knocked': [913], 'out': [914, 951, 4333, 4599, 4956], 'mice,': [916], 'neither': [918], 'distal': [919], 'tubular': [920], 'acidosis': [921], 'nor': [922], 'hyperammonemia': [923], 'detected': [925, 2349, 3027, 3566], '(11Chambrey': [926], 'R.': [927, 1074, 4650], 'Goossens': [928], 'Quentin': [930], 'F.': [931, 1134, 4481], 'Eladari': [932], 'Transfus.': [934], 'Clin.': [935], '13:': [938], '154-158Crossref': [939], '(9)': [942], 'assumption': [946, 2059], 'double': [949], 'knock': [950], 'both': [953, 1180, 1864, 1997, 2571, 3431], 'leads': [958], 'detectable': [961], 'remains': [963], 'tested.': [966, 2923], 'expectation': [968], 'based': [970, 4786], 'on': [971, 3252, 4787, 4839], 'observation': [973, 3519], 'apical': [976, 1059, 3450], 'membranes': [977, 1127, 2413, 2452, 2812, 3448, 3451], 'AQP8-expressing': [979], 'cells': [980, 2420, 3454], 'must': [981], 'maintain': [982, 4200], 'large': [983], 'chemical': [984, 2097, 2210, 2297, 2322, 3077], 'gradients': [987], 'therefore': [989, 1045], 'effectively': [991], 'impermeable': [992], 'molecules,': [995, 2549, 3385], 'including': [996], 'water.': [999, 3379, 3995, 4113], 'Tightening': [1000], 'lipid': [1003, 1249, 1253, 1479, 1493, 2423, 2548, 2558, 2583, 2617, 2809], 'matrix': [1004], 'and,': [1005, 3368], 'thus,': [1006, 3369], 'reduced': [1008, 3209], 'achieved': [1011], 'concentrations': [1014, 1808, 4430, 4981], 'glycosphingolipids': [1016], 'sphingomyelin': [1018], 'outer': [1021], 'leaflet': [1023], '(12Krylov': [1024, 2432], 'A.V.': [1025, 2433], 'Pohl': [1026, 1425, 1622, 2012, 2106, 2127, 2272, 2369, 2434, 2902, 2949, 3107, 3128, 3606, 3711, 3734, 4015, 4045, 4512], 'Zeidel': [1028, 2436], 'M.L.': [1029, 2437], 'Hill': [1030, 2438], 'W.G.': [1031, 2439], 'Gen.': [1033, 2441, 4716], '2001;': [1035, 1150, 1430, 1627, 1655, 2374, 2402, 2443, 2890, 3739, 3767, 4097], '118:': [1036, 2444], '333-340Crossref': [1037, 2445], '(71)': [1040, 2448], 'not': [1046, 1172, 1215, 2801, 2851, 3572, 3776, 3867, 4176, 4457, 4873], 'surprising': [1047], 'that,': [1048], 'expression': [1052, 2722, 3533, 3659, 4351], 'hepatic': [1054], 'associated': [1057], 'microdomain': [1060], 'fractions': [1061], 'enriched': [1062], 'cholesterol': [1064], 'sphingolipids': [1066], '(13Mazzone': [1067], 'Tietz': [1069], 'Jefferson': [1071], 'Pagano': [1073], 'Larusso': [1075], 'N.F.': [1076, 1144], 'Hepatology.': [1077], '43:': [1079], '287-296Crossref': [1080], '(68)': [1083, 3897], 'With': [1086, 3793], 'respect': [1087], 'low': [1090, 2456, 3704, 4148], 'basal': [1091, 4986], 'epithelial': [1096, 1256, 2419, 3453], 'membrane,': [1097, 2994], 'requirement': [1099], 'controllable': [1101], 'proteinaceous': [1102], 'machinery': [1105], 'becomes': [1106], 'obvious.': [1107], 'ideal': [1111], 'candidate': [1112], 'because': [1113, 3657, 3701, 3983, 4401, 4600], 'largely': [1116], 'localized': [1117], 'can': [1122, 3392, 4330, 4596, 4726], 'redistributed': [1124], 'plasma': [1126, 1257, 4244, 4552], 'via': [1128], 'microtubule-dependent,': [1130], 'cAMP-stimulated': [1131], 'mechanism': [1132, 1165, 4593, 4765, 4772], '(14Garcia': [1133], 'Kierbel': [1135], 'Larocca': [1137], 'M.C.': [1138], 'Gradilone': [1139], 'S.A.': [1140], 'Splinter': [1141], 'La-Russo': [1143], 'Marinelli': [1145], 'R.A.': [1146, 3677], '276:': [1151, 1431, 1628, 2375, 3740], '12147-12152Abstract': [1152], '(178)': [1160], 'molecular': [1164, 1510, 2608, 2775, 3420, 3942, 4840], 'yet': [1173], 'been': [1174, 4409, 4543, 4778], 'resolved.': [1175], 'Evidence': [1176], 'reported': [1178, 2716, 4146], 'showing': [1179], 'Scholar),': [1211, 2450, 3500, 3622, 4425, 4450, 4860], 'although': [1212, 3164], 'possible': [1216], 'differentiate': [1218], 'occurred': [1222], 'aquaporin': [1225, 3465, 4393], 'itself': [1226], 'secondary': [1229], 'effects': [1230], 'related': [1231, 1771], 'took': [1236], 'place.': [1237], 'We': [1238, 1285, 2410, 3425, 4992], 'addressed': [1240], 'this': [1241, 1767, 3903, 4329], 'question': [1242], 'reconstituting': [1244], 'bilayers': [1250, 2347, 2810, 3045, 3696, 4282], 'mimicking': [1251, 3449], 'composition': [1254, 2417], 'membranes.': [1258], 'Functional': [1259], 'reconstitution': [1260, 1446, 2071, 2783, 3354], 'confirmed': [1262], 'flux': [1265, 1271, 1964, 2053, 2940, 3213, 3250, 4289, 4622], 'measurements.': [1266], 'Simultaneous': [1267], 'ion': [1268, 2821, 2847, 3564, 3666, 3724, 4405, 4453, 4946], 'measurements': [1272], 'perfect': [1274, 4336], 'selectivity,': [1276], 'i.e.': [1277, 3508], 'silent.': [1284], 'exceeds': [1290], '2-fold,': [1293], 'Expression': [1305], 'Purification': [1307], 'from': [1310, 1363, 1683, 2503, 2567, 3214, 3233, 3311, 3504, 4205, 4562, 4639, 4782], 'Yeast—Rat': [1311], 'expressed': [1314], 'pep4Δ': [1316], 'Saccharomyces': [1317], 'cerevisiae': [1318], 'previously': [1322, 2717], 'described': [1323], 'brief,': [1343, 1444], 'after': [1344, 2069], 'induction': [1345], '2%': [1347], '(w/w)': [1348], 'galactose': [1349], 'harvested': [1350, 1535], 'centrifugation,': [1352], 'three': [1354], 'French': [1355], 'press': [1356], 'cycles,': [1357], 'fraction': [1360], 'recovered': [1362], 'supernatant': [1365], 'ultracentrifugation.': [1367], 'solubilized': [1371], 'n-octyl-β-d-glucoside.': [1373], 'His10-tagged': [1375], 'absorbed': [1378], 'nickel': [1381], 'column.': [1382], 'Its': [1383, 1944], 'purity': [1384], 'better': [1386, 2870], '90%': [1388], 'comparison': [1393], 'Coomassie-stained': [1395], 'SDS': [1396], 'gels': [1397], 'bands': [1399], 'obtained': [1400, 1757, 2644, 3907], 'immunoblotting.': [1402], 'Protein': [1403, 3158], 'Reconstitution': [1404, 2467, 2659, 3258, 3437], 'Planar': [1406], 'Bilayers—Purified': [1407], 'proteoliposomes': [1414], 'dialysis': [1416, 1508], '(15Saparov': [1417, 1614, 2361, 3726], 'Rothe': [1421, 1618, 2365, 3730], 'U.': [1422, 1619, 1652, 2366, 2399, 2677, 2887, 3731, 3764, 3836, 4021, 4044, 4079, 4657, 4675, 4714, 4751, 4827], '31515-31520Abstract': [1432, 1629, 2376, 3741], '(104)': [1440, 1637, 2384, 2685, 3749], 'mixture': [1447, 1488, 1670, 1828], 'prepared': [1449], 'at': [1450, 1530, 1540, 1553, 1713, 1863, 1946, 1956, 2003, 2470, 3882, 4189, 4887], 'room': [1451], 'temperature': [1452], 'sequentially': [1454], 'adding': [1455], '100': [1456, 1522], 'mm': [1457], 'MOPS-sodium,': [1458], '7.5': [1460], '(Fluka,': [1461, 1834], 'Buchs,': [1462], 'Switzerland),': [1463], '1.25%': [1464], '(w/v)': [1465], 'octyl': [1466], 'glucoside,': [1467], '(final': [1470], '0.5–1': [1472], 'mg/ml),': [1473], '20–50': [1475], 'mg/ml': [1476], 'preformed': [1478], 'vesicles.': [1480], 'latter': [1482, 1980], 'consisted': [1483], '3:2:1': [1486], 'molar': [1487, 2557], 'cholesterol,': [1490], 'coli': [1492, 2422], 'extract': [1494], '(Avanti': [1495], 'Polar': [1496], 'Lipids,': [1497], 'Alabaster,': [1498], 'AL),': [1499], 'sphingomyelin.': [1501], 'loaded': [1504], 'SPECTRA/POR': [1506], '2.1': [1507], 'tubing,': [1509], 'weight': [1511], 'cut-off': [1512], '15,000': [1513], '(Spectrum': [1514], 'Laboratories,': [1515], 'Laguna': [1516], 'Hills,': [1517], 'CA),': [1518], 'dialyzed': [1520], 'volumes': [1523], 'assay': [1525, 1548], 'buffer': [1526, 1549, 1861, 1939, 2001], '48': [1528], 'h': [1529], '4': [1531, 2188, 2589, 2601], '°C.': [1532], 'Proteoliposomes': [1533], 'ultracentrifugation': [1537], '(60': [1538], 'min': [1539], '100,000': [1541], 'g)': [1543], 'resuspended': [1546], '(compare': [1550, 2873], 'Fig.': [1551, 3206], '1)': [1552], '5–10': [1557], 'mg/ml.': [1558], 'At': [1559, 2219, 2924, 4310], 'air-water': [1561], 'interface': [1562], 'vesicle': [1564], 'suspensions,': [1565], 'monolayers': [1566, 1589], 'formed': [1568, 2411], 'spontaneously': [1569], '(16Montal': [1570], 'Darszon': [1572], 'Schindler': [1574], 'Q.': [1576], 'Biophys.': [1578, 1697, 2016, 2110, 2129, 2274, 2731, 2953, 3111, 3130, 3610, 3680, 4360], '1981;': [1579], '14:': [1580], '1-79Crossref': [1581], 'Two': [1587], 'such': [1588, 4270], 'combined': [1591], 'form': [1593], 'bilayer': [1596, 2553, 3228, 4296], '150-μm-diameter': [1599], 'aperture': [1600], '25-μm-thick': [1603], 'polytetrafluoroethylene': [1604], 'septum': [1605, 1664], 'separating': [1606], 'two': [1608, 2568], 'aqueous': [1609, 2944, 2983, 3590, 4314], 'phases': [1610], 'chamber': [1613], 'Scholar,': [1639, 2122, 2386, 2897, 3123, 3488, 3751, 4031, 4089, 4503, 4812], '17Pohl': [1640, 2387, 2875, 3752], 'Saparov': [1642, 1693, 2389, 2877, 3754], 'Borgnia': [1644, 2391, 2879, 3756], 'M.J.': [1645, 2392, 2880, 3757], 'Proc.': [1648, 2395, 2673, 2883, 3760, 3832, 4017, 4075, 4653, 4823], 'Natl.': [1649, 2396, 2674, 2884, 3761, 3833, 4018, 4076, 4654, 4824], 'Acad.': [1650, 2397, 2675, 2885, 3762, 3834, 4019, 4077, 4655, 4825], 'Sci.': [1651, 2398, 2676, 2886, 3763, 3835, 4020, 4078, 4420, 4656, 4826], '9624-9629Crossref': [1657, 2404, 2892, 3769], '(83)': [1660, 2407, 2895, 3772], 'pretreated': [1666], 'hexadecane-hexane': [1669], '(volume': [1671], '1:200).': [1674], 'Water': [1675, 1781, 2520], 'Flux': [1676, 1853, 1932], 'Measurements—Transmembrane': [1677], 'flow': [1680, 1745, 2334], 'solute': [1684, 1711], 'dilution': [1685], 'immediate': [1688, 1976, 2101, 3274], 'vicinity': [1690, 2103, 3276], '(18Pohl': [1691], 'Antonenko': [1695, 2265], 'Y.N.': [1696, 2011, 2105, 2124, 2269, 2948, 3106, 3125, 3605], '1997;': [1699, 2018, 2112, 2734, 2955, 3113, 3612, 4363, 4496], '72:': [1700, 2019, 2113, 2956, 3114, 3613], '1711-1718Abstract': [1701], '(53)': [1707], 'interface,': [1715, 2222], 'Cs,': [1716], 'distance,': [1720], 'x,': [1721], 'membrane:': [1724], 'C(x)': [1725], '=': [1726, 1776, 2150, 2154, 2159, 2162, 2182, 2185, 2189, 2192, 2195, 2244, 2246, 2248, 2250, 2252, 2255, 2425, 2475, 2591, 2594, 2597, 2623, 2759, 2761, 2836], 'Cs': [1727], 'exp(–vx/D': [1728], '+': [1729], 'bx3/3D),': [1730], 'where': [1731, 2180, 2563, 2602, 2765, 3341, 3410], '–v': [1732], 'b': [1734, 2622], '–': [1736, 3001], 'linear': [1738, 3063], 'drift': [1739], 'velocity': [1740, 3976], 'stirring': [1748], 'parameter,': [1749], 'respectively.': [1750, 2620, 2779, 2995, 3157, 3424], 'steady': [1753], 'state,': [1754], 'v': [1755, 1769], 'fitting': [1759], 'distribution': [1762], 'Na+': [1764, 1807], 'ions': [1765, 3503], 'equation.': [1768], 'Pf': [1773, 1775, 2483, 2590], 'v/(Cosm': [1777], 'Vw)': [1778], '(19Finkelstein': [1779, 2518], 'Movement': [1782, 1837, 2029, 2521], 'Lipid': [1784, 2523], 'Bilayers,': [1785, 2524], 'Pores,': [1786, 2525], 'Plasma': [1788, 2527], 'Membranes.': [1789, 2528], '1987;': [1790, 2529], '(Wiley': [1791, 2530], '&': [1792, 2531], 'Sons,': [1793, 2532], 'New': [1794, 2533], 'York):': [1795, 2534], '10-41Google': [1796, 2535], 'Jw': [1798], 'product': [1801], 'v.': [1806], 'measured': [1810, 1878, 1982, 2331, 3197], 'microelectrodes': [1812], 'made': [1813, 3528], 'glass': [1815], 'capillaries,': [1816], 'tips': [1818], '(1–2': [1819], 'μm': [1820, 3104], 'diameter)': [1822], 'which': [1824, 4123, 4320, 4537], 'filled': [1826], 'A': [1829, 1920, 2792, 3004, 4591, 4770], 'Sodium': [1831], 'Ionophore': [1832], 'I': [1833, 4795, 4909], 'Dreisenhofen,': [1835], 'Germany).': [1836], 'electrodes': [1840, 1856, 2032], 'relative': [1841, 2033], 'realized': [1846, 2038], 'hydraulic': [1849, 2041, 2495, 2506], 'stepdrive': [1850, 2042], '(Narishige).': [1851, 2043], 'Ion': [1852], 'Measurements—Ag/AgCl': [1854], 'reference': [1855, 1995], 'immersed': [1858], 'solutions': [1862, 1940, 2289], 'sides': [1865], 'bilayers.': [1869], 'Under': [1870], 'conditions,': [1873, 2262], 'patch': [1881], 'amplifier': [1883], '(model': [1884], 'EPC9;': [1885], 'HEKA': [1886], 'Electronics).': [1887], 'recording': [1889], 'filter': [1890, 1922], '4-pole': [1893], 'Bessel': [1894], '3-dB': [1896], 'corner': [1897], 'frequency': [1898], '0.1': [1900], 'kHz.': [1901], 'acquired': [1903], 'raw': [1904], 'data': [1905], 'analyzed': [1907, 2081], 'help': [1910], 'TAC': [1913], 'software': [1914], 'package': [1915], '(Bruxton': [1916], 'Corp.,': [1917], 'Seattle,': [1918], 'WA).': [1919], 'Gaussian': [1921], '0.3': [1924], 'Hz': [1925], 'applied': [1927], 'reduce': [1929], 'noise.': [1930], 'Ammonia': [1931], 'Measurements—Ammonium': [1933], 'chloride': [1934], 'added': [1936], 'surrounding': [1941], 'bilayer.': [1943], 'cis': [1948], 'side': [1949, 2006], 'higher': [1954, 3371, 3910, 3958], 'trans': [1958], 'side.': [1959], 'gave': [1965], 'rise': [1966, 2936, 3631], 'vicinity.': [1978], 'potential': [1987, 3188], 'difference': [1988, 3033], 'microelectrode': [1992, 3167, 3187], 'electrode,': [1996], 'placed': [1998], 'solution': [2002, 3591, 3601], 'same': [2005, 2694, 4731], '(20Antonenko': [2010, 2104, 2947, 3105, 3604], 'Denisov': [2014, 2108, 2125, 2270, 2951, 3109, 3126, 3608], 'G.A.': [2015, 2109, 2126, 2271, 2668, 2952, 3110, 3127, 3609], '2187-2195Abstract': [2020, 2114, 2957, 3115, 3614], '(67)': [2026, 2120, 2963, 3121, 3620], 'Theoretical': [2044], 'Model': [2045], 'Transport—In': [2048], 'model,': [2050], 'neglected.': [2057], 'justified': [2061], 'any': [2066], 'incremental': [2067, 2487, 3345], 'conductivity': [2068, 2507, 2833, 4988], '(Fig.': [2072, 2484, 2816, 3040, 3046, 3065, 3277, 3331], '2).': [2073, 2817], 'For': [2074, 2259, 2621, 3242, 3295], 'acidic': [2075, 2925], 'experimental': [2078, 3097, 3313], 'precisely': [2082], 'solving': [2084], 'complete': [2086, 3239], 'system': [2087, 2723, 3534, 3570, 4297, 4352], 'differential': [2089, 3086, 3284], 'equations': [2090, 3087, 3285], 'takes': [2092, 4948], 'account': [2094, 3074], 'relevant': [2096], 'reactions': [2098, 2211, 2298, 3078], '21Antonenko': [2123, 3124], '1993;': [2131, 2276, 3132], '64:': [2132, 2277, 3133], '1701-1710Abstract': [2133, 2278, 3134], '(55)': [2139, 2284, 3140], 'Scholar)': [2141, 2965, 3722, 3774, 4174, 4230, 4667, 4696, 4725, 4761, 4837], 'shown': [2143, 2239, 2586, 2754, 2967, 3204, 3335, 3404, 3427, 3932], 'Equations': [2145, 2969], '1': [2146, 2157, 2181, 2212, 2216, 4610, 4745], '2.': [2148, 2214], 'Ji': [2149], '-': [2151], 'Didci/dxi,': [2152], 'i': [2153], '1,…,6': [2155], 'eq.': [2156, 2164], 'dJi/dx': [2158], 'Ri(c),': [2160], 'c': [2161], '(c1,…,c6)': [2163], '2': [2165, 2184, 2218, 3811], 'Ji,': [2166], 'Di,': [2167], 'ci(x)': [2168], 'denote,': [2169], 'respectively,': [2170], 'flux,': [2171, 2848, 2930], 'coefficient,': [2173], 'ith': [2178, 2207], 'species,': [2179], 'H+,': [2183], 'NH3,': [2186, 2987, 3423], 'NH+4,': [2187, 2988], 'OH–,': [2190], '5': [2191, 2757, 2764, 2837], 'MES–,': [2193], '6': [2194, 2864], 'H-MES.': [2196], 'Ri(c)': [2197], 'specific': [2200], 'local': [2201, 2321], 'rate': [2202, 2312, 3865], 'expenditure': [2204], 'species': [2208, 2227, 4381, 4940], 'H++NH3⇄NH4+;H++OH-⇄H2OReaction': [2215], 'H++MES-⇄H-MESReaction': [2217], 'membrane-water': [2221], 'fluxes': [2224, 3565, 4237, 4608], 'required': [2229, 4434, 4942], 'equal': [2232, 2542, 2998, 3358], 'zero,': [2234], 'except': [2235], 'J2,': [2237], 'Equation': [2241, 2588, 2756, 2861, 3337, 3406, 3934, 4105], '3.': [2242], 'J1': [2243], 'J3': [2245], 'J4': [2247], '…': [2249], 'J8': [2251], '0;': [2253], 'J2': [2254], 'J': [2256], 'Eq.': [2257, 2600, 2763], '3': [2258], 'boundary': [2261], 'please': [2263], 'compare': [2264], 'et': [2266], 'al.': [2267], '(21Antonenko': [2268], 'numerical': [2288], 'derived,': [2291], 'assuming': [2292, 2645, 3987], 'rates': [2295, 3879], '(like': [2299], 'dissociation/recombination': [2300], 'water,': [2302, 2751, 2778, 4969], 'buffer,': [2303], 'NH3)': [2305], 'compared': [2309, 4618], 'USL,': [2317], 'so': [2318, 4403], 'maintained.': [2325], 'To': [2326], 'demonstrate': [2327], 'functional': [2328, 2782], 'reconstitution,': [2329], 'we': [2330, 3905, 4952], 'channels': [2338, 2510, 3667], 'mimicked': [2415], '(cholesterol:E.': [2421], 'extract:sphingomyelin': [2424], '3:2:1).': [2426], 'line': [2428], 'previous': [2430], 'exhibited': [2453], 'permeability,': [2459, 2489], 'Pf,': [2460], '(11.0': [2463], '±': [2464, 2634, 2702, 3361], '1.5)': [2465], 'μm/s.': [2466], 'lipid:protein': [2471], 'mass': [2472], 'ratio,': [2473, 2561], 'rm': [2474], '100,': [2476], 'resulted': [2477], '3-fold': [2480], 'increase': [2481], '1).': [2485], 'Pf.c,': [2490], 'allowed': [2491, 3324], 'calculation': [2492, 2744, 3325, 3396], 'channel,': [2501, 3507], 'pf,': [2502], 'absolute': [2505], 'Pf.c': [2511, 2592, 2595, 2598], 'number': [2514, 2546, 2772, 3381, 3400, 3417, 3809], 'channels,': [2516], 'n': [2517, 2537], 'total': [2545, 2846], 'L,': [2550], 'divided': [2554, 2577], 'r,': [2562], 'L': [2564], 'times': [2569], '(for': [2570], 'leaflets)': [2572], 'area,': [2575, 2580], 'A,': [2576], 'b,': [2581], 'per': [2582, 3390, 3401], 'molecule': [2584], 'A/n': [2593], 'Ar/2L': [2596], 'brmMP/2ML': [2599], 'MP': [2603], 'ML': [2605], 'masses': [2609], '(30': [2613], 'kDa)': [2614], '(700': [2618], 'Da),': [2619], '70': [2624], 'A2,': [2625], 'pf': [2626, 2696, 2742, 4340], '(2.4': [2633], '0.2)': [2635, 3362], 'cm3': [2638, 2706, 3365], 'subunit–1': [2639, 2707, 3366], 's–1.': [2640, 2708, 3220], 'result': [2642, 4115], 'incorporation': [2648], '100%': [2650], 'efficient.': [2651], 'real': [2653], 'efficiency': [2654, 3355], 'is,': [2655], 'most': [2656, 3461], 'probably,': [2657], 'smaller.': [2658], 'AQP0,': [2661], '∼50%': [2665], 'efficient': [2666], '(22Zampighi': [2667], 'Hall': [2669], 'J.E.': [2670], 'Kreman': [2671], '1985;': [2680], '82:': [2681, 3482], '8468-8472Crossref': [2682], 'If': [2688], 'our': [2689], 'value': [2690, 2699], 'range,': [2695], 'adopts': [2697], '∼(1.2': [2701], '0.1)': [2703], 'That': [2709], 'reasonable': [2712], 'agreement': [2713, 3901], 'using': [2718, 4891], 'Xenopus': [2720, 3531, 3670], '(23Ma': [2724, 4353], 'Yang': [2726, 4355, 4484], 'Biochem.': [2730, 4359, 4752], 'Res.': [2732, 4361], 'Commun.': [2733, 4362], '240:': [2735, 4364], '324-328Crossref': [2736, 4365], '(166)': [2739, 4368], 'allows': [2743, 3510], 'turnover': [2748, 3399], 'numbers': [2749], 'TW': [2752, 3911], 'Tw': [2758], 'NApf/Vw': [2760], '4·108s-1': [2762], 'NA': [2766, 3411], 'VW': [2768], 'Avogadro': [2771, 3416], 'Demonstration': [2780], 'followed': [2785], 'probing': [2787], 'hundredfold': [2793], 'augmentation': [2794], 'NH4Cl': [2797], 'bulk': [2798, 4012], 'did': [2800, 2850], 'alter': [2802], 'characteristics': [2806], 'bare': [2808, 3039, 3153], 'similarity': [2819], 'conductivities': [2822], 'indicated': [2823, 3048], 'excluded': [2826, 4728], 'ions.': [2828], 'Even': [2829], 'if': [2830], 'entire': [2832, 4277], 'G': [2835], 'nS': [2838], 'cm–2': [2839, 2855, 3219, 4614, 4626], 'attributed': [2841], 'protein,': [2844], 'jion,': [2849], 'exceed': [2852], '10–15': [2853, 4612], 'mol': [2854, 4613], 's–1': [2856, 3367, 4615, 4627], 'calculated': [2858], 'according': [2859], '6.': [2862], 'Jion=RTz2F2GEq.': [2863], 'Consequently,': [2865], 'ion:water': [2867], 'selectivity': [2868, 4862], '1:109': [2872], 'Refs.': [2874], '24Saparov': [2898], 'Tsunoda': [2900, 3709], 'S.P.': [2901, 3710, 4505], '97:': [2907, 3716], '545-550Crossref': [2908, 3717], '(38)': [2911, 3720], 'Subsequently,': [2914], 'molecules': [2919, 3965, 4967], 'pH,': [2926], 'JMNH3,': [2931], 'expected': [2933], 'give': [2935], 'near-membrane': [2943], 'stagnant': [2945], 'layers': [2946], '7': [2970, 2974], '8.': [2972], 'JNH3M=-DNH3d[NH3]dx-DNH4+d[NH4+dxEq.': [2973], 'JNH3M=-DNH4+d[NH4+]dx(1+α)Eq.': [2975], '8': [2976], 'DNH3,': [2977], 'DNH4+,': [2978], 'x': [2980], 'coefficients': [2985, 3921], 'distance': [2991], 'α': [2996], '10(pH': [3000], 'p': [3002], 'K).': [3003], 'imposed': [3009], 'bilayer,': [3013], 'scanning': [3029], 'ammonia-selective': [3030, 3166], 'microelectrodes.': [3031], 'polarization': [3036, 3271], '3A)': [3041], '3B)': [3047], 'aquaporins.': [3052], 'Plotting': [3053, 3317], 'JMNH3': [3054], 'reveals': [3061, 4107], 'dependence': [3064, 3251], '3C).': [3066], 'Calculation': [3067], 'PJNH3': [3069], 'performed': [3071], 'taking': [3072], 'accompanying': [3076], 'buffer.': [3082], 'set': [3084, 3282], '(see': [3088, 3286], '“Experimental': [3089, 3287], 'Procedures”)': [3090, 3288], 'solved': [3092, 3290], 'numerically': [3093, 3291], 'fit': [3095], 'profiles': [3098], '0': [3100], '<': [3101], '<50': [3103], 'permeabilities': [3144, 3445, 3725], '16': [3146], '105': [3148, 3796], 'μm/s': [3149], 'computed': [3151], 'AQP8-containing': [3155], 'inhibition': [3159], 'Hg2+': [3161, 3175, 3208], 'testable,': [3163], 'less': [3169, 3950, 3963], 'sensitive': [3170], 'presence': [3173], '(a': [3176], '10-fold': [3177], 'change': [3178, 3185], 'corresponded': [3182], '27': [3191], 'mV': [3192], 'instead': [3193], 'usually': [3196], '52': [3198], 'mV).': [3199], 'particular': [3202], 'experiment': [3203], '4,': [3207], '0.2': [3215], '0.06': [3217], 'nmol': [3218, 4625], 'Thus,': [3221, 3955], 'decreased': [3232], '50': [3234], '15': [3236], 'μm/s,': [3237], 'indicating': [3238], 'inhibition.': [3241], 'further': [3243], 'proof': [3244], 'conductance': [3247, 4935, 4947], 'AQP8,': [3249, 3779], 'abundance': [3255], 'measured.': [3257], 'increasing': [3260, 3268], 'amounts': [3261], 'accompanied': [3265], '5).': [3278, 3913], 'As': [3279, 3460], 'before,': [3280], 'different': [3293, 4251, 4307], 'PMNH3.': [3294], 'each': [3296], 'parameter': [3300], 'changed': [3302], 'iteratively': [3303], 'until': [3304], 'deviation': [3306], 'theoretical': [3309], 'profile': [3310], 'one': [3314, 4348], 'minimal.': [3316], 'PMNH3': [3318], '1/rm': [3323], '5,': [3332], 'inset)': [3333], '9': [3338, 3340], 'pNH3=PNH3,cA/n=PNH3,cbrmMp/2MLEq.': [3339], 'PNH3,c': [3342], 'introduced': [3348], 'reconstitution.': [3351], 'Assuming': [3352], '50%': [3353], 'pNH3': [3356], 'respective': [3374, 3444, 3808], 'TNH3,': [3386], 'transported': [3387], 'second': [3391], 'assessed': [3394], '10': [3407, 3409], 'TNH3=NApNH3/VNH3=7.7⋅105s-1Eq.': [3408], 'VNH3': [3413], 'transports': [3430, 3789, 3962], 'efficiently.': [3436, 3792], 'increased': [3442], 'model': [3447], 'up': [3455, 3628], '3-': [3457, 4989], '6-fold.': [3459], '(25Nielsen': [3467], 'Frokiaer': [3469], 'Marples': [3471], 'Knepper': [3477], 'M.A.': [3478], '2002;': [3481, 4421, 4684], '205-244Crossref': [3483], '(1005)': [3486], '26Pohl': [3489], '385:': [3494], '921-926Crossref': [3495], '(28)': [3498], 'prevents': [3502], 'passing': [3505], 'exclusive': [3511], 'molecule.': [3517], 'contrasts': [3520, 4767], 'proposed': [3523, 4636, 4779], 'necessarily': [3573], 'fluxes.': [3575], 'represent': [3579], 'endogenous': [3580, 3668], 'pH-sensitive': [3581], 'currents': [3582, 4881], 'oocyte.': [3585], 'acidifies': [3588], 'leaves': [3593], 'behind': [3594], 'augments': [3596], 'enters': [3603], 'proton': [3625, 3633, 3706, 4265, 4902], 'builds': [3627], 'gives': [3630], 'counterion': [3635], 'currents,': [3636], 'provided': [3637], 'permeable': [3642], 'charged': [3645, 4380, 4939], 'species.': [3646], 'Subtracting': [3647], 'non-transfected': [3652], 'oocytes': [3653, 3671], 'misleading': [3656], 'integral': [3661], 'modify': [3665], '(27Shimbo': [3672], 'Brassard': [3674], 'D.L.': [3675], 'Lamb': [3676], 'Pinto': [3678], 'L.H.': [3679], '1995;': [3682], '69:': [3683], '1819-1829Abstract': [3684], '(86)': [3690], 'disadvantages': [3699], 'their': [3702, 3940, 3957], 'extremely': [3703, 4147], 'intrinsic': [3705], '(24Saparov': [3707], 'altered': [3777], 'excludes': [3786], '∼8': [3794], 'substrate': [3797], 'molecules/s/channel': [3798], '(Equation': [3799, 3912, 4628], '10),': [3800], 'TNH3': [3801], 'comparable': [3805], '106': [3813], 'estimated': [3814, 4602], 'human': [3817], 'rhesus-associated': [3818], 'glycoprotein': [3819], '(28Ripoche': [3820], 'Bertrand': [3822], 'O.': [3823, 4072, 4652], 'Gane': [3824], 'Birkennmeier': [3826], 'C.': [3827, 4706], 'Colin': [3828, 4707], 'Cartron': [3830, 4711], 'J.P.': [3831, 4095, 4712], '101:': [3840, 4025, 4831], '17222-17227Crossref': [3841], '(141)': [3844], 'physiological': [3849, 4972, 4980], 'orders': [3853], 'magnitude': [3855], 'H2O,': [3861], 'conduction': [3864], 'need': [3866], 'H2O': [3874, 3930], 'match': [3876, 4337], 'limited': [3878], 'arriving': [3881], 'pore': [3884, 4315, 4387], '(29Winkler': [3885], 'F.K.': [3886, 4820], 'Pflugers.': [3887], '451:': [3893], '701-707Crossref': [3894], 'prediction,': [3904], '500-fold': [3909], 'Comparison': [3914], 'actual': [3917, 3975], 'reveals,': [3922], 'contrast,': [3924], 'preference': [3926, 4109, 4963], 'over': [3929, 4112, 4968], '11.': [3935], 'pf/pNH3=1.2/2.7≅1/2Eq.': [3936], '11': [3937, 4106], 'larger': [3941], '(VNH3': [3944], '≫': [3945], 'VW),': [3946], 'accommodates': [3949], 'gas': [3951], 'molecules.': [3954, 3968], 'albeit': [3956], 'velocity,': [3960], 'should': [3970, 4231], 'noted': [3972], 'underestimated': [3982], 'pores': [3990], 'densely': [3992], 'packed': [3993], 'file': [3998], 'transport,': [3999], 'density': [4001], 'inside': [4004], 'lower': [4009], '(30Saparov': [4013], '4805-4809Crossref': [4026], '(64)': [4029], '31Saparov': [4032], 'Pfeifer': [4034], 'J.R.': [4035], 'Al-Momani': [4036], 'L.': [4037, 4814], 'Portella': [4038], 'de': [4040], 'Groot': [4041], 'B.L.': [4042], 'Koert': [4043], 'Phys.': [4047], '96:': [4051], '148101Crossref': [4052], '(41)': [4055], 'Molecular': [4058], 'dynamics': [4059, 4841], 'simulations': [4060, 4842], 'support': [4061], 'view': [4063], 'liquid-vapor': [4065], 'oscillations': [4066], 'occur': [4067], '(32Beckstein': [4071], 'Sansom': [4073], 'M.S.': [4074], '2003;': [4082], '100:': [4083], '7063-7068Crossref': [4084], '(374)': [4087], '33Hummer': [4090], 'Rasaiah': [4092], 'J.C.': [4093], 'Noworyta': [4094], '414:': [4098], '188-190Crossref': [4099], '(2869)': [4102], 'conflicts': [4116], 'cell': [4119], 'culture': [4120], 'fluorescence': [4125], 'pH-sensing': [4128], 'yellow': [4129], 'fluorescent': [4130], 'assess': [4135], 'rat': [4136], 'mouse': [4138], 'permeability.': [4141], 'reason': [4143], 'NH3-to-water': [4152], '0.03': [4156], 'clear.': [4177], 'kinetics': [4184, 4741], 'are,': [4188], 'least': [4190, 4311], 'part,': [4192], 'determined': [4193], 'compensatory': [4195], 'events': [4197], 'aimed': [4198], 'cellular': [4201], 'pH.': [4202], 'Calculating': [4203], 'PNH3': [4204], 'time': [4207], 'course': [4208], 'alone': [4212], 'hampered': [4233], '(i)': [4234, 4402], 'passive': [4236], 'CO2': [4239], '(ii)': [4249, 4426], 'types': [4252], 'pH-regulating': [4254], 'transporters,': [4255, 4260], 'like': [4256], 'cation-H+': [4257], 'exchangers,': [4258], 'HCO¯3': [4259], 'H+-ATPases,': [4262], '(iii)': [4264, 4452], 'exchange': [4266, 4564], 'compartments': [4269], 'lysosomes.': [4274], 'Lacking': [4275], 'list': [4278], 'uncertainties,': [4280], 'offer': [4283], 'opportunity': [4285], 'measure': [4287, 4933], 'directly.': [4290], 'uncertainty': [4293], 'adopt': [4304], 'slightly': [4306], 'quaternary': [4308], 'structure.': [4309], 'monomer,': [4319], 'path': [4324], 'ruled': [4332, 4598], 'values': [4341], 'Theoretically,': [4371], 'there': [4372], 'still': [4374], 'possibility': [4376], 'occurs': [4382], 'putative': [4385], 'fifth': [4386], 'center': [4390], 'tetramer.': [4394], 'unlikely': [4398], 'far': [4404], 'activity': [4407, 4455], 'ascribed': [4410], 'AQP1': [4413], '(34Yool': [4414], 'A.J.': [4415, 4440], 'Weinstein': [4416], 'A.M.': [4417], 'News': [4418], '17:': [4422], '68-72PubMed': [4423], 'nonphysiologically': [4427], 'cGMP': [4429], '(1': [4431], 'mm)': [4432], '(35Boassa': [4435], 'Stamer': [4437], 'W.D.': [4438], 'Yool': [4439], 'Neurosci.': [4442], '26:': [4444], '7811-7819Crossref': [4445], '(79)': [4448], 'reproduced': [4458], 'variety': [4461], 'laboratories': [4463], '(36Agre': [4464], 'Lee': [4466], 'M.D.': [4467], 'Devidas': [4468], 'Sasaki': [4472], 'Uchida': [4474], 'Kuwahara': [4476], 'Fushimi': [4478], 'Marumo': [4480], 'Deen': [4486], 'P.M.T.': [4487], 'Mulders': [4488], 'Kansen': [4490], 'van': [4492], 'Os': [4493], 'C.H.': [4494], 'Science.': [4495, 4804, 4918], '275:': [4497], '1490-1492Crossref': [4498], '(84)': [4501, 4723], '37Tsunoda': [4504], 'Wiesner': [4506], 'Lorenz': [4508], 'Rosenthal': [4510], '279:': [4518], '11364-11367Abstract': [4519], '(48)': [4527], 'ammonia-transporting': [4534], 'shown.': [4544], 'net': [4546], 'kidney': [4555], 'glycoproteins': [4557], 'RhCG': [4560], '(38Mak': [4569], 'D-O.': [4570], 'Dang': [4572], 'Weiner': [4574], 'I.D.': [4575], 'Foskett': [4576], 'Westhoff': [4578], 'C.M.': [4579], '290:': [4584], 'F297-F305Crossref': [4585], '(102)': [4588], 'similar': [4592], 'upper': [4603], 'limit': [4604], 'negligible': [4617], '∼0.4': [4624], '6).': [4629], 'NH3/H+': [4630], 'cotransport': [4631], 'AMT-1': [4638], 'hyperthermophilic': [4641], 'archaeon': [4642], 'Archaeglobus': [4643], 'fulgidus': [4644], '(39Andrade': [4645], 'S.L.': [4646], 'Dickmanns': [4647], 'Ficner': [4649], 'Einsle': [4651], '102:': [4661], '14994-14999Crossref': [4662], '(185)': [4665], 'plant': [4670], 'transporters': [4672], 'LeAMT1': [4673], '(40Ludewig': [4674], 'von': [4676], 'Wiren': [4677], 'N.': [4678], 'Frommer': [4679], '277:': [4685], '13548-13555Abstract': [4686], '(206)': [4694], 'LeAMT2': [4698], '(41Mayer': [4699], 'Schaaf': [4701], 'Mouro': [4703], 'I.': [4704], 'Lopez': [4705], 'Neumann': [4709], 'Ludewig': [4713, 4750], '127:': [4719], '133-144Crossref': [4720], 'reason.': [4732], 'Exclusion': [4733], 'saturable': [4739], 'LeAMT1;': [4744], '(42Mayer': [4746], 'Dynowski': [4748], '396:': [4755], '431-437Crossref': [4756], '(62)': [4759], 'indicate': [4762], 'much': [4773], 'closer': [4774], 'AmtB': [4781], 'coli.': [4784], 'Mainly': [4785], 'structural': [4788], 'considerations': [4789], '(43Khademi': [4790, 4904], "O'Connell": [4792, 4906], 'II': [4794, 4908], 'Remis': [4796, 4910], 'Robles-Colmenares': [4798, 4912], 'Miercke': [4800, 4914], 'L.J.': [4801, 4915], 'Stroud': [4802, 4916], 'R.M.': [4803, 4917], '305:': [4806, 4920], '1587-1594Crossref': [4807, 4921], '(542)': [4810, 4924], '44Zheng': [4813], 'Kostrewa': [4815], 'Berneche': [4817], 'Winkler': [4819], 'Li': [4821], 'X.D.': [4822], '17090-17095Crossref': [4832], '(280)': [4835], '(45Lin': [4843], 'Cao': [4845], 'Z.': [4846], 'Mo': [4847], 'Soc.': [4852], '128:': [4854], '10876-10884Crossref': [4855], '(65)': [4858], 'suggested.': [4864], 'occasional': [4866], 'passage': [4867], 'excluded.': [4874], 'would': [4876], 'stabilized': [4878], 'ring': [4880], 'rich': [4884], 'aromatic': [4885], 'environment': [4886], 'constriction': [4889], 'zone': [4890], 'acid/base': [4893], 'properties': [4894], 'imidazole': [4897], 'nitrogens': [4898], 'assist': [4900], 'transfer': [4903], 'authors': [4928], 'establish': [4944], 'place,': [4949], 'now': [4953], 'carried': [4955], 'Summarizing,': [4959], 'exhibits': [4961], 'role': [4973], 'maintenance': [4975], 'equilibrium.': [4978], 'augment': [4984], '5-fold.': [4991], 'thank': [4993], 'Quentina': [4994], 'Beatty': [4995], 'critically': [4997], 'reading': [4998], 'manuscript.': [5000]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2005279807', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-04T21:05:52.017371', 'created_date': '2016-06-24'}