Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2944132920', 'doi': 'https://doi.org/10.1111/febs.14922', 'title': 'Gating in plant plasma membrane aquaporins: the involvement of leucine in the formation of a pore constriction in the closed state', 'display_name': 'Gating in plant plasma membrane aquaporins: the involvement of leucine in the formation of a pore constriction in the closed state', 'publication_year': 2019, 'publication_date': '2019-05-11', 'ids': {'openalex': 'https://openalex.org/W2944132920', 'doi': 'https://doi.org/10.1111/febs.14922', 'mag': '2944132920', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31077546'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/febs.14922', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14922', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14922', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040961381', 'display_name': 'Agustina Canessa Fortuna', 'orcid': 'https://orcid.org/0000-0002-3362-1255'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Agustina Canessa Fortuna', 'raw_affiliation_strings': ['Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}, {'raw_affiliation_string': 'Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018773110', 'display_name': 'Gerardo Zerbetto De Palma', 'orcid': 'https://orcid.org/0000-0003-4235-8978'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}, {'id': 'https://openalex.org/I4392738055', 'display_name': 'Universidad Nacional de Hurlingham', 'ror': 'https://ror.org/00p094v10', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4392738055']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Zerbetto De Palma', 'raw_affiliation_strings': ['Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina', 'Instituo de Biotecnología Universidad Nacional de Hurlingham Villa Tesei Argentina'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}, {'raw_affiliation_string': 'Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I24354313']}, {'raw_affiliation_string': 'Instituo de Biotecnología Universidad Nacional de Hurlingham Villa Tesei Argentina', 'institution_ids': ['https://openalex.org/I4392738055']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065922215', 'display_name': 'Lucio Aliperti Car', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53241121', 'display_name': 'Fundación Ciencias Exactas y Naturales', 'ror': 'https://ror.org/05rxmkq09', 'country_code': 'AR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I53241121']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Lucio Aliperti Car', 'raw_affiliation_strings': ['Laboratorio de Fisiología de Proteínas IQUIBICEN y Facultad de Ciencias Exactas y Naturales CONICET Universidad de Buenos Aires Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Fisiología de Proteínas IQUIBICEN y Facultad de Ciencias Exactas y Naturales CONICET Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I53241121', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039115804', 'display_name': 'Luciano Armentia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Luciano Armentia', 'raw_affiliation_strings': ['Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064178160', 'display_name': 'Victoria Vitali', 'orcid': 'https://orcid.org/0000-0002-1031-9328'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Victoria Vitali', 'raw_affiliation_strings': ['Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}, {'raw_affiliation_string': 'Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052410919', 'display_name': 'Ari Zeida', 'orcid': 'https://orcid.org/0000-0003-0938-287X'}, 'institutions': [{'id': 'https://openalex.org/I180910786', 'display_name': 'Universidad de la República', 'ror': 'https://ror.org/030bbe882', 'country_code': 'UY', 'type': 'education', 'lineage': ['https://openalex.org/I180910786']}], 'countries': ['UY'], 'is_corresponding': False, 'raw_author_name': 'Ari Zeida', 'raw_affiliation_strings': ['Departamento de Bioquímica Facultad de Medicina Center for Free Radical and Biomedical Research Universidad de la República Montevideo Uruguay'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica Facultad de Medicina Center for Free Radical and Biomedical Research Universidad de la República Montevideo Uruguay', 'institution_ids': ['https://openalex.org/I180910786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027457760', 'display_name': 'Darío A. Estrı́n', 'orcid': 'https://orcid.org/0000-0002-5006-7225'}, 'institutions': [{'id': 'https://openalex.org/I53241121', 'display_name': 'Fundación Ciencias Exactas y Naturales', 'ror': 'https://ror.org/05rxmkq09', 'country_code': 'AR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I53241121']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Darío A. Estrin', 'raw_affiliation_strings': ['DQIAQF-INQUIMAE, Facultad de Ciencias Exactas y Naturales, CONICET, Universidad de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'DQIAQF-INQUIMAE, Facultad de Ciencias Exactas y Naturales, CONICET, Universidad de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I53241121', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026234525', 'display_name': 'Karina Alleva', 'orcid': 'https://orcid.org/0000-0002-9081-2103'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': True, 'raw_author_name': 'Karina Alleva', 'raw_affiliation_strings': ['Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina'], 'affiliations': [{'raw_affiliation_string': 'Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológica (IQUIFIB) CONICET Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}, {'raw_affiliation_string': 'Departamento de Fisicomatemática Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Argentina', 'institution_ids': ['https://openalex.org/I24354313']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5026234525'], 'corresponding_institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313'], 'apc_list': {'value': 4580, 'currency': 'USD', 'value_usd': 4580, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.15, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '286', 'issue': '17', 'first_page': '3473', 'last_page': '3487'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12074', 'display_name': 'Membrane-based Ion Separation Techniques', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/constriction', 'display_name': 'Constriction', 'score': 0.7668967}], 'concepts': [{'id': 'https://openalex.org/C194544171', 'wikidata': 'https://www.wikidata.org/wiki/Q21105679', 'display_name': 'Gating', 'level': 2, 'score': 0.8660842}, {'id': 'https://openalex.org/C174940676', 'wikidata': 'https://www.wikidata.org/wiki/Q495626', 'display_name': 'Constriction', 'level': 2, 'score': 0.7668967}, {'id': 'https://openalex.org/C154280991', 'wikidata': 'https://www.wikidata.org/wiki/Q623090', 'display_name': 'Aquaporin', 'level': 2, 'score': 0.7093659}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.6594491}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.577422}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46864435}, {'id': 'https://openalex.org/C82706917', 'wikidata': 'https://www.wikidata.org/wiki/Q10251', 'display_name': 'Plasma', 'level': 2, 'score': 0.43161672}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22437313}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17752457}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17310482}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17062119}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.120740086}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015640', 'descriptor_name': 'Ion Channel Gating', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020346', 'descriptor_name': 'Aquaporins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027461', 'descriptor_name': 'Beta vulgaris', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056004', 'descriptor_name': 'Molecular Dynamics Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/febs.14922', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14922', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11336/130775', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/130775/5/CONICET_Digital_Nro.8fa5b357-c617-4aca-b2a3-00e085fba4f1_D.pdf', 'source': {'id': 'https://openalex.org/S4306402455', 'display_name': 'CONICET Digital (CONICET)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210148385', 'host_organization_name': 'Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I4210148385'], 'host_organization_lineage_names': ['Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31077546', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/febs.14922', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14922', 'source': {'id': 'https://openalex.org/S37672443', 'display_name': 'FEBS Journal', 'issn_l': '1742-464X', 'issn': ['1742-464X', '1742-4658'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.84, 'display_name': 'Clean water and sanitation'}], 'grants': [{'funder': 'https://openalex.org/F4320310753', 'funder_display_name': 'Agencia Nacional de Investigación e Innovación', 'award_id': None}, {'funder': 'https://openalex.org/F4320334832', 'funder_display_name': 'Agencia Nacional de Promoción Científica y Tecnológica', 'award_id': 'PICT 2017‐0244'}, {'funder': 'https://openalex.org/F4320334832', 'funder_display_name': 'Agencia Nacional de Promoción Científica y Tecnológica', 'award_id': 'PICT 2015‐2761'}], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1512016817', 'https://openalex.org/W1525279604', 'https://openalex.org/W1947778485', 'https://openalex.org/W1976499671', 'https://openalex.org/W1988857299', 'https://openalex.org/W1990771438', 'https://openalex.org/W1999151180', 'https://openalex.org/W1999340580', 'https://openalex.org/W2009611240', 'https://openalex.org/W2009851764', 'https://openalex.org/W2011679999', 'https://openalex.org/W2015079610', 'https://openalex.org/W2015415318', 'https://openalex.org/W2019650166', 'https://openalex.org/W2021520922', 'https://openalex.org/W2029360750', 'https://openalex.org/W2032067567', 'https://openalex.org/W2038270621', 'https://openalex.org/W2039835476', 'https://openalex.org/W2040923822', 'https://openalex.org/W2043901383', 'https://openalex.org/W2050679273', 'https://openalex.org/W2053693922', 'https://openalex.org/W2069363866', 'https://openalex.org/W2078936885', 'https://openalex.org/W2079280170', 'https://openalex.org/W2084304818', 'https://openalex.org/W2086007235', 'https://openalex.org/W2086546323', 'https://openalex.org/W2089463543', 'https://openalex.org/W2090082061', 'https://openalex.org/W2092398899', 'https://openalex.org/W2104599553', 'https://openalex.org/W2109311481', 'https://openalex.org/W2113773631', 'https://openalex.org/W2115422240', 'https://openalex.org/W2115979934', 'https://openalex.org/W2117541248', 'https://openalex.org/W2127322768', 'https://openalex.org/W2131438940', 'https://openalex.org/W2134762386', 'https://openalex.org/W2135080621', 'https://openalex.org/W2145611758', 'https://openalex.org/W2146762773', 'https://openalex.org/W2151769450', 'https://openalex.org/W2153598588', 'https://openalex.org/W2154365500', 'https://openalex.org/W2159350975', 'https://openalex.org/W2165091323', 'https://openalex.org/W2168269595', 'https://openalex.org/W2170711116', 'https://openalex.org/W2212237386', 'https://openalex.org/W2320601283', 'https://openalex.org/W2330282848', 'https://openalex.org/W2339004220', 'https://openalex.org/W2399186596', 'https://openalex.org/W2404280981', 'https://openalex.org/W2510475640', 'https://openalex.org/W2511879068', 'https://openalex.org/W2527743689', 'https://openalex.org/W2563719958', 'https://openalex.org/W2586049680', 'https://openalex.org/W2600824575', 'https://openalex.org/W2614386918', 'https://openalex.org/W2626410045', 'https://openalex.org/W2726771639', 'https://openalex.org/W2804822363', 'https://openalex.org/W2899545382', 'https://openalex.org/W2899887243', 'https://openalex.org/W2900848843', 'https://openalex.org/W2951832640', 'https://openalex.org/W3155424557', 'https://openalex.org/W4246696773'], 'related_works': ['https://openalex.org/W812052363', 'https://openalex.org/W4306385464', 'https://openalex.org/W3142543453', 'https://openalex.org/W2591905584', 'https://openalex.org/W2467703106', 'https://openalex.org/W2154009044', 'https://openalex.org/W2113681449', 'https://openalex.org/W2075302665', 'https://openalex.org/W2032067567', 'https://openalex.org/W2031449089'], 'abstract_inverted_index': {'The': [0, 166], 'control': [1], 'of': [2, 15, 52, 81, 119, 130, 146, 177], 'water': [3, 23, 53, 101, 131, 154, 187], 'permeability': [4, 155], 'in': [5, 22, 36, 42, 83, 108, 111, 189], 'plant': [6], 'PIP2': [7, 37, 62], 'aquaporins': [8], 'has': [9, 29, 70], 'become': [10], 'a': [11, 39, 61, 97, 181], 'paradigmatic': [12], 'case': [13], 'study': [14, 78], 'the': [16, 33, 50, 56, 79, 120, 123, 144, 159, 174, 178], 'capping': [17], 'mechanism': [18], 'for': [19, 127], 'pore': [20, 160], 'closure': [21], 'channels.': [24], 'From': [25], 'structural': [26], 'data,': [27], 'it': [28], 'been': [30, 71], 'postulated': [31], 'that': [32, 45, 92, 99, 116, 143, 170], 'gating': [34, 85], 'process': [35], 'involves': [38], 'conformational': [40], 'rearrangement': [41], 'cytosolic': [43, 88], 'loopD': [44], 'generates': [46], 'an': [47, 149], 'obstruction': [48], 'to': [49, 163], 'transport': [51, 188], 'molecules': [54], 'inside': [55], 'aquaporin': [57, 63], 'pore.': [58], 'BvPIP2;2': [59, 84], 'is': [60, 125, 161], 'from': [64, 107], 'Beta': [65], 'vulgaris': [66], 'whose': [67], 'pH': [68], 'response': [69], 'thoroughly': [72], 'characterized.': [73], 'In': [74], 'this': [75, 93], 'work,': [76], 'we': [77, 114], 'participation': [80], 'Leu206': [82, 147], 'triggered': [86], 'by': [87, 148], 'acidification': [89], 'and': [90, 110, 137], 'show': [91], 'residue': [94, 151], 'acts': [95], 'as': [96], 'plug': [98], 'blocks': [100], 'transport.': [102], 'Based': [103], 'on': [104], 'data': [105], 'obtained': [106], 'silico': [109], 'vitro': [112], 'studies,': [113], 'demonstrate': [115], 'Leu206,': [117, 171], 'one': [118], 'residues': [121], 'lining': [122], 'pore,': [124], 'responsible': [126], '~': [128], '60%': [129], 'blockage.': [132], 'Cell': [133], 'osmotic': [134], 'swelling': [135], 'experiments': [136], 'atomistic': [138], 'molecular': [139], 'dynamics': [140], 'simulations': [141], 'indicate': [142], 'replacement': [145], 'Ala': [150], 'maintains': [152], 'high': [153], 'under': [156], 'conditions': [157], 'where': [158], 'expected': [162], 'be': [164], 'closed.': [165], 'present': [167], 'work': [168], 'demonstrates': [169], 'located': [172], 'at': [173], 'cytoplasmic': [175], 'entry': [176], 'channel,': [179], 'constitutes': [180], 'crucial': [182], 'pH-sensitive': [183], 'steric': [184], 'gate': [185], 'regulating': [186], 'PIP': [190], 'aquaporins.': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2944132920', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2025-01-04T09:30:49.452048', 'created_date': '2019-05-16'}