Title: Toward an understanding of transfusion‐related acute lung injury: statement of a consensus panel
Abstract: TransfusionVolume 44, Issue 12 p. 1774-1789 Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel Steven Kleinman, Steven Kleinman From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorTim Caulfield, Tim Caulfield From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPenny Chan, Penny Chan From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorRobertson Davenport, Robertson Davenport From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorJanice McFarland, Janice McFarland From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorSusan McPhedran, Susan McPhedran From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorMaureen Meade, Maureen Meade From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorDouglas Morrison, Douglas Morrison From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorThomas Pinsent, Thomas Pinsent From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPierre Robillard, Pierre Robillard From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPeter Slinger, Peter Slinger From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this author Steven Kleinman, Steven Kleinman From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorTim Caulfield, Tim Caulfield From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPenny Chan, Penny Chan From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorRobertson Davenport, Robertson Davenport From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorJanice McFarland, Janice McFarland From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorSusan McPhedran, Susan McPhedran From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorMaureen Meade, Maureen Meade From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorDouglas Morrison, Douglas Morrison From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorThomas Pinsent, Thomas Pinsent From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPierre Robillard, Pierre Robillard From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this authorPeter Slinger, Peter Slinger From Kleinman Biomedical Research, Victoria, British Columbia, Canada; the University of British Columbia, Vancouver, British Columbia, Canada; the University of Alberta, Edmonton, Alberta, Canada; Toronto, Ontario, Canada; the University of Michigan, Ann Arbor, Michigan; The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin; Elora, Ontario; Canada; McMaster University, Hamilton, Ontario, Canada; the Royal Columbian Hospital, New Westminster, British Columbia, Canada; Halifax, Nova Scotia, Canada; the Québec Public Health Institute, Montreal, Quebec, Canada; McGill University, Montreal, Quebec, Canada; and the University of Toronto, Toronto, Ontario, Canada.Search for more papers by this author First published: 02 December 2004 https://doi.org/10.1111/j.0041-1132.2004.04347.xCitations: 548 Morris Blajchman, MD, Depts. of Pathology and Medicine, McMaster University, 1200 Main St., West, HSC 2N34, Hamilton, Ontario, Canada L8N 3ZS; e-mail: [email protected]. Dr Meade is a Peter Lougheed Scholar of the Canadian Institutes of Health Research. This Consensus Conference was funded by Canadian Blood Services and Héma-Québec, with additional support from the International Society of Blood Transfusion's Biomedical Excellence for Safer Transfusion (BEST) subcommittee. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Goldman M, Webert KE, Arnold DM, Hannon J, Blajchman MA. Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev 2005; 19: in press. 10.1016/j.tmrv.2004.10.001 PubMedWeb of Science®Google Scholar 2 Bernard GR, Artigas A, Righam KL, et al. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-24. 10.1164/ajrccm.149.3.7509706 CASPubMedWeb of Science®Google Scholar 3 Garber BG, Heber PC, Yelle JD, Hodder RV, McGowan J. Adult respiratory distress syndrome: a systematic overview of incidence and risk factors. Crit Care Med 1996; 24: 687-95. 10.1097/00003246-199604000-00023 CASPubMedWeb of Science®Google Scholar 4 Ferguson ND, Meade MO, Hallett DC, Stewart TE. High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome. Intensive Care Med 2002; 28: 1073-7. 10.1007/s00134-002-1354-y PubMedWeb of Science®Google Scholar 5 Meade MO, Cook RJ, Guyatt GH, et al. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med 2000; 161: 85-90. 10.1164/ajrccm.161.1.9809003 CASPubMedWeb of Science®Google Scholar 6 Silliman CC, Boshkov LK, Mehdizadehkashi Z, et al. Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood 2003; 101: 454-62. 10.1182/blood-2002-03-0958 CASPubMedWeb of Science®Google Scholar 7 Williamson L. SHOT experience and the UK initiatives on TRALI prevention and their potential impact. In Goldman M, Webert KE, Arnold DM, Hannon J, Blajchman MA. Transfus Med Rev 2005; 19: in press. Google Scholar 8 Wallis JP, Lubenko A, Wells AW, Chapman CE. Single hospital experience of TRALI. Transfusion 2003; 43: 1053-9. 10.1046/j.1537-2995.2003.00466.x PubMedWeb of Science®Google Scholar 9 Popovsky MA, Chaplin HC Jr, Moore SB. Transfusion-related acute lung injury. a neglected, serious complication of hemotherapy. Transfusion 1992; 32: 589-92. 10.1046/j.1537-2995.1992.32692367207.x PubMedWeb of Science®Google Scholar 10 Kopko P. Antibody hypothesis of TRALI. In Goldman M, Webert KE, Arnold DM, Hannon J, Blajchman MA. Transfus Med Rev 2005; 19: in press. Google Scholar 11 Faber JC. Haemovigilance around the world. Vox Sang 2002; 83(Suppl 1): 71-6. 10.1111/j.1423-0410.2002.tb05271.x PubMedWeb of Science®Google Scholar 12 Silliman CC, Paterson AJ, Dickey WO, et al. The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion 1997; 37: 719-26. 10.1046/j.1537-2995.1997.37797369448.x CASPubMedWeb of Science®Google Scholar 13 Popovsky MA, Davenport RD. Transfusion-related acute lung injury: femme fatale? (editorial). Transfusion 2001; 41: 312-5. 10.1046/j.1537-2995.2001.41030312.x CASPubMedWeb of Science®Google Scholar 14 Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA. Transfusion-related acute lung injury: report of a clinical lookback investigation. JAMA 2002; 287: 1963- 71. 10.1001/jama.287.15.1968 Web of Science®Google Scholar 15 Cooling L. Transfusion-related acute lung injury (letter). JAMA 2002; 288: 315-6. 10.1001/jama.288.3.315 PubMedWeb of Science®Google Scholar 16 Win N, Ranasinghhe E, Lucas G. Transfusion-related acute lung injury: a 5-year lookback study (letter). Transfus Med 2002; 12: 387-9. 10.1046/j.1365-3148.2002.00401_1.x CASPubMedWeb of Science®Google Scholar 17 Webert KE, Blajchman MA. Transfusion related acute lung injury. Transfus Med Rev 2003; 17: 252-62. 10.1016/S0887-7963(03)00039-7 PubMedWeb of Science®Google Scholar 18 Davoran A, Curtis BR, Shulman IA, et al. TRALI due to granulocyte-agglutinating human neutrophil antigen-3a (5b) alloantibodies in donor plasma: a report of two fatalities. Transfusion 2003; 43: 641-5. 10.1046/j.1537-2995.2003.00374.x PubMedWeb of Science®Google Scholar 19 Palfi M, Soren B, Ernerudh J, Berlin G. A randomized controlled trial of transfusion-related acute lung injury: is plasma from multiparous blood donors dangerous? Transfusion 2001; 41: 317-22. 10.1046/j.1537-2995.2001.41030317.x CASPubMedWeb of Science®Google Scholar 20 Suskind B. Murine model of TRALI. In Goldman M, Webert KE, Arnold DM, Hannon J, Blajchman MA. Murine model of TRALI. Transfus Med Rev 2005; 19: in press. Google Scholar 21 Seeger W, Schneider U, Kreusler B, et al. Reproduction of transfusion-related acute lung injury in an ex-vivo lung model. Blood 1990; 76: 1438-44. CASPubMedWeb of Science®Google Scholar 22 Silliman CC, Bjornsen AJ, Wyman TH, et al. Plasma and lipids from stored platelets cause acute lung injury in an animal model. Transfusion 2003; 43: 633-40. 10.1046/j.1537-2995.2003.00385.x PubMedWeb of Science®Google Scholar 23 Silliman CC, Voelkel NF, Allard JD, et al. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest 1998; 101: 1458-67. 10.1172/JCI1841 CASPubMedWeb of Science®Google Scholar 24 Wyman TH, Bjornsen AJ, Elzi DJ, et al. A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release. Am J Physiol Cell Physiol 2002; 283: C1592-C1603. 10.1152/ajpcell.00540.2001 CASPubMedWeb of Science®Google Scholar 25 Dykes A, Smallwood D, Kotsimbos T, Street A. Transfusion related acute lung injury (TRALI) in a patient with a single lung transplant. Br J Haematol 2000; 109: 674-6. 10.1046/j.1365-2141.2000.01999.x CASPubMedWeb of Science®Google Scholar 26 Kao GS, Wood IG, Dorfman DM, Milford EL, Benjamin RJ. Investigations into the role of anti-HLA class II antibodies in TRALI. Transfusion 2003; 43: 185-91. 10.1046/j.1537-2995.2003.00285.x CASPubMedWeb of Science®Google Scholar 27 Kopko PM, Paglieroni TG, Popovsky MA, et al. TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion 2003; 43: 177-84. 10.1046/j.1537-2995.2003.00307.x CASPubMedWeb of Science®Google Scholar 28 Biffl WL, Moore EE, Moore FA, et al. Interleukin-8 increases endothelial permeability independent of neutrophils. J Trauma 1995; 39: 98-103. 10.1097/00005373-199507000-00013 CASPubMedWeb of Science®Google Scholar 29 Reibl v. Hughes, 114 D.L.R. (3rd) 1 (S.C.C.) (1980). Google Scholar 30 Holness L, Knippen MA, Simmons L, Lachenbruch PA. Fatalities caused by TRALI. Transfus Med Rev 2004; 18: 184-8. 10.1016/j.tmrv.2004.03.004 PubMedWeb of Science®Google Scholar 31 Robillard P, Itaj NK. Incidence of adverse transfusion reactions in the Quebec Hemovigilance system 2000-01 (abstract). Transfusion 2003; 43(Suppl): 22A. Google Scholar Citing Literature Volume44, Issue12December 2004Pages 1774-1789 ReferencesRelatedInformation