Abstract: This chapter reviews transfusion-related acute lung injury (TRALI), which is a clinical syndrome presented as shortness of breath secondary to allogeneic transfusion and can be accompanied by non-cardiogenic pulmonary edema, fever and hypotension. The diagnosis of TRALI is based on clinical and radiographic findings and chest x-ray often shows bilateral infiltrates involving both alveolar and interstitial spaces, without cardiomegaly. For management of TRALI, it is critical that the transfusion be stopped and a transfusion reaction reported to the blood bank and intravenous steroids have been utilized, but their efficacy is not confirmed. Patients with a history of TRALI should receive no future blood products from the implicated donor. In cases, where an antibody of donor origin is implicated, the patient is not thought to be at increased risk for future TRALI episodes following the transfusion of products from other donors. In order to prevent TRALI, preferential transfusion of plasma from male donors is done to decrease the transfusion of anti-HLA antibodies from multiparous women and thus decrease the incidence of TRALI.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 3
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