Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2004578380', 'doi': 'https://doi.org/10.1016/0006-291x(89)92366-8', 'title': 'Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells', 'display_name': 'Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells', 'publication_year': 1989, 'publication_date': '1989-07-01', 'ids': {'openalex': 'https://openalex.org/W2004578380', 'doi': 'https://doi.org/10.1016/0006-291x(89)92366-8', 'mag': '2004578380', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2787988'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0006-291x(89)92366-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/27842/1/0000252.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004985444', 'display_name': 'Robert M. Strieter', 'orcid': 'https://orcid.org/0000-0002-1516-2390'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R.M. Strieter', 'raw_affiliation_strings': ['Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022290728', 'display_name': 'Roger C. Wiggins', 'orcid': 'https://orcid.org/0000-0002-1166-2849'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. Wiggins', 'raw_affiliation_strings': ['Division of Nephrology, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Nephrology, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077346838', 'display_name': 'Sem H. Phan', 'orcid': 'https://orcid.org/0000-0002-3711-2159'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S.H. Phan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049482789', 'display_name': 'Bryan L. Wharram', 'orcid': 'https://orcid.org/0000-0002-5132-4000'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B.L. Wharram', 'raw_affiliation_strings': ['Division of Nephrology, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Nephrology, Department of Internal Medicine, The University of Michigan Medical School Ann Arbor, Michigan USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028582089', 'display_name': 'Henry J. Showell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180857899', 'display_name': 'Pfizer (United States)', 'ror': 'https://ror.org/01xdqrp08', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I180857899']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H.J. Showell', 'raw_affiliation_strings': ['Department of Immunology, Pfizer Central Research, Groton, Connecticut, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Pfizer Central Research, Groton, Connecticut, USA', 'institution_ids': ['https://openalex.org/I180857899']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007616136', 'display_name': 'Daniel G. Remick', 'orcid': 'https://orcid.org/0000-0002-2615-3713'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D.G. Remick', 'raw_affiliation_strings': ['Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044846381', 'display_name': 'Stephen W. Chensue', 'orcid': 'https://orcid.org/0000-0001-5159-5196'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S.W. Chensue', 'raw_affiliation_strings': ['Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038875877', 'display_name': 'S L Kunkel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S.L. Kunkel', 'raw_affiliation_strings': ['Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, USA.', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.711, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 245, 'citation_normalized_percentile': {'value': 0.97286, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '162', 'issue': '2', 'first_page': '694', 'last_page': '700'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10519', 'display_name': 'Mass Spectrometry Techniques with Proteins', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/monocyte', 'display_name': 'Monocyte', 'score': 0.6396376}, {'id': 'https://openalex.org/keywords/inflammation', 'display_name': 'Inflammation', 'score': 0.465265}], 'concepts': [{'id': 'https://openalex.org/C54166955', 'wikidata': 'https://www.wikidata.org/wiki/Q658145', 'display_name': 'Chemotaxis', 'level': 3, 'score': 0.7053563}, {'id': 'https://openalex.org/C2781184567', 'wikidata': 'https://www.wikidata.org/wiki/Q107244', 'display_name': 'Monocyte', 'level': 2, 'score': 0.6396376}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.604706}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.60123163}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48807347}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.45277646}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4049619}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33319232}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28873497}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15968508}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.15670764}], 'mesh': [{'descriptor_ui': 'D002630', 'descriptor_name': 'Chemotactic Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002630', 'descriptor_name': 'Chemotactic Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0006-291x(89)92366-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/27842', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/27842/1/0000252.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': 'mit', 'license_id': 'https://openalex.org/licenses/mit', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2787988', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/27842', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/27842/1/0000252.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': 'mit', 'license_id': 'https://openalex.org/licenses/mit', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.62, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1493935825', 'https://openalex.org/W1511533680', 'https://openalex.org/W1581990512', 'https://openalex.org/W1589218234', 'https://openalex.org/W1983239749', 'https://openalex.org/W2046196550', 'https://openalex.org/W2060333964', 'https://openalex.org/W2068593333', 'https://openalex.org/W2072036820', 'https://openalex.org/W2074430638', 'https://openalex.org/W2081119605', 'https://openalex.org/W2085534295', 'https://openalex.org/W2101157641'], 'related_works': ['https://openalex.org/W2417007386', 'https://openalex.org/W2388783242', 'https://openalex.org/W2350646269', 'https://openalex.org/W2085357479', 'https://openalex.org/W2071968695', 'https://openalex.org/W2051602839', 'https://openalex.org/W2026568037', 'https://openalex.org/W2024585522', 'https://openalex.org/W1993973863', 'https://openalex.org/W1596865785'], 'abstract_inverted_index': {'A': [0], 'number': [1], 'of': [2, 9, 25, 31, 43, 60, 124, 130], 'cytokines': [3], 'are': [4], 'active': [5, 119], 'during': [6], 'the': [7, 40, 54, 122, 128], 'evolution': [8], 'an': [10, 118], 'inflammatory': [11, 32, 125], 'response,': [12], 'including': [13], 'tumor': [14, 71, 90], 'necrosis': [15, 72, 91], 'factor-α,': [16], 'interleukin-1,': [17], 'and': [18], 'novel': [19, 131], 'chemotactic': [20, 62, 82, 132], 'cytokines.': [21, 133], 'This': [22], 'latter': [23], 'group': [24], 'mediators': [26], 'belong': [27], 'to': [28, 79, 87, 107], 'supergene': [29], 'families': [30], 'signals': [33], 'that': [34, 112], 'play': [35, 117], 'a': [36], 'key': [37], 'role': [38, 120], 'in': [39, 85, 105, 121], 'selective': [41], 'recruitment': [42, 123], 'immune': [44], 'cells.': [45], 'In': [46, 98], 'this': [47], 'presentation,': [48], 'we': [49], 'present': [50], 'data': [51], 'demonstrating,': [52], 'for': [53], 'first': [55], 'time,': [56], 'endothelial': [57], 'cell': [58], 'expression': [59], 'monocyte': [61, 81], 'protein': [63], '(MCP)': [64], 'mRNA': [65, 84], 'induced': [66], 'by': [67], 'LPS,': [68], 'interleukin-1': [69, 88], 'or': [70, 89], 'factor.': [73], 'Human': [74], 'fibroblasts': [75], 'were': [76], 'also': [77], 'found': [78], 'express': [80], 'factor': [83], 'response': [86, 106], 'factor,': [92], 'but': [93], 'LPS': [94], 'was': [95], 'not': [96], 'effective.': [97], 'addition,': [99], 'neither': [100], 'primary': [101], 'cultures': [102], 'expressed': [103], 'MCP': [104], 'interleukin-6.': [108], 'These': [109], 'studies': [110], 'demonstrate': [111], 'non-immune': [113], '"bystander"': [114], 'cells': [115, 126], 'can': [116], 'via': [127], 'production': [129]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2004578380', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-20T00:01:18.468827', 'created_date': '2016-06-24'}