Publication Information

{'id': 'https://openalex.org/W2003299861', 'doi': 'https://doi.org/10.1021/jm800527x', 'title': 'Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase', 'display_name': 'Design of Annulated Pyrazoles as Inhibitors of HIV-1 Reverse Transcriptase', 'publication_year': 2008, 'publication_date': '2008-11-14', 'ids': {'openalex': 'https://openalex.org/W2003299861', 'doi': 'https://doi.org/10.1021/jm800527x', 'mag': '2003299861', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19007201'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm800527x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011016701', 'display_name': 'Zachary K. Sweeney', 'orcid': 'https://orcid.org/0000-0002-9852-1802'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zachary K. Sweeney', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053687855', 'display_name': 'Seth F. Harris', 'orcid': 'https://orcid.org/0000-0003-1728-9771'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Seth F. Harris', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103268670', 'display_name': 'Nidhi Arora', 'orcid': 'https://orcid.org/0000-0003-0345-4844'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nidhi Arora', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021307674', 'display_name': 'Hassan Javanbakht', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hassan Javanbakht', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100345949', 'display_name': 'Yu Li', 'orcid': 'https://orcid.org/0000-0003-4359-4411'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu Li', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029786336', 'display_name': 'Jennifer Fretland', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Fretland', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038844502', 'display_name': 'James P. Davidson', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James P. Davidson', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062016504', 'display_name': 'J. Roland Billedeau', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Roland Billedeau', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072420688', 'display_name': 'Shelley Gleason', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shelley K. Gleason', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024060294', 'display_name': 'Donald R. Hirschfeld', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donald Hirschfeld', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000071022', 'display_name': 'Joshua J. Kennedy‐Smith', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joshua J. Kennedy-Smith', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109358585', 'display_name': 'Taraneh Mirzadegan', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Taraneh Mirzadegan', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004702578', 'display_name': 'Ralf Roetz', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ralf Roetz', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061004952', 'display_name': 'Mark A. Smith', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Smith', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037470689', 'display_name': 'Sarah L.W. Sperry', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah Sperry', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035536263', 'display_name': 'Judy M. Suh', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Judy M. Suh', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111122326', 'display_name': 'Jeffrey Wu', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey Wu', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068754201', 'display_name': 'Stan Tsing', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stan Tsing', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011485982', 'display_name': 'Armando G. Villaseñor', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Armando G. Villaseñor', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041881133', 'display_name': 'Amber M. Paul', 'orcid': 'https://orcid.org/0000-0002-1657-3618'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amber Paul', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103545187', 'display_name': 'Guoping Su', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guoping Su', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090129258', 'display_name': 'Gabrielle Heilek', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gabrielle Heilek', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090500679', 'display_name': 'Julie Q. Hang', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie Q. Hang', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007526549', 'display_name': 'Amy S. Zhou', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy S. Zhou', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024090042', 'display_name': 'Jesper A. Jernelius', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jesper A. Jernelius', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039458269', 'display_name': 'Fangjie Zhang', 'orcid': 'https://orcid.org/0000-0002-7502-5830'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fang-Jie Zhang', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076998022', 'display_name': 'Klaus Klumpp', 'orcid': 'https://orcid.org/0000-0002-4829-3127'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Klaus Klumpp', 'raw_affiliation_strings': ['Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304'], 'affiliations': [{'raw_affiliation_string': 'Departments of Medicinal Chemistry, Discovery Sciences and Technologies, Viral Disease Biology, Viral Disease Biochemistry, Non-Clinical Safety, and Chemical Synthesis, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.719, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.940671, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '51', 'issue': '23', 'first_page': '7449', 'last_page': '7458'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/reverse-transcriptase-inhibitor', 'display_name': 'Reverse-transcriptase inhibitor', 'score': 0.6884285}, {'id': 'https://openalex.org/keywords/efavirenz', 'display_name': 'Efavirenz', 'score': 0.52522826}, {'id': 'https://openalex.org/keywords/nevirapine', 'display_name': 'Nevirapine', 'score': 0.43329802}], 'concepts': [{'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.93068326}, {'id': 'https://openalex.org/C153574943', 'wikidata': 'https://www.wikidata.org/wiki/Q408939', 'display_name': 'Nucleotidyltransferase', 'level': 4, 'score': 0.78797746}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7111563}, {'id': 'https://openalex.org/C2777351918', 'wikidata': 'https://www.wikidata.org/wiki/Q421559', 'display_name': 'Reverse-transcriptase inhibitor', 'level': 5, 'score': 0.6884285}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.6384673}, {'id': 'https://openalex.org/C2909970146', 'wikidata': 'https://www.wikidata.org/wiki/Q421559', 'display_name': 'Nucleoside Reverse Transcriptase Inhibitor', 'level': 5, 'score': 0.601751}, {'id': 'https://openalex.org/C2781432083', 'wikidata': 'https://www.wikidata.org/wiki/Q422645', 'display_name': 'Efavirenz', 'level': 5, 'score': 0.52522826}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.50273037}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4991536}, {'id': 'https://openalex.org/C2779130552', 'wikidata': 'https://www.wikidata.org/wiki/Q263713', 'display_name': 'Nevirapine', 'level': 5, 'score': 0.43329802}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.4144801}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.4139273}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.24203447}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18928903}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14814308}, {'id': 'https://openalex.org/C2993143319', 'wikidata': 'https://www.wikidata.org/wiki/Q583050', 'display_name': 'Antiretroviral therapy', 'level': 4, 'score': 0.13807854}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.07664865}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054303', 'descriptor_name': 'HIV Reverse Transcriptase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002461', 'descriptor_name': 'Cell Line, Transformed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054303', 'descriptor_name': 'HIV Reverse Transcriptase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054303', 'descriptor_name': 'HIV Reverse Transcriptase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000882', 'descriptor_name': 'Haplorhini', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006860', 'descriptor_name': 'Hydrogen Bonding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013237', 'descriptor_name': 'Stereoisomerism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm800527x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19007201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.8, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1963535341', 'https://openalex.org/W1965075634', 'https://openalex.org/W1969062060', 'https://openalex.org/W1973711348', 'https://openalex.org/W1974645077', 'https://openalex.org/W1983144547', 'https://openalex.org/W1986569038', 'https://openalex.org/W2001641653', 'https://openalex.org/W2007434340', 'https://openalex.org/W2023089361', 'https://openalex.org/W2038840577', 'https://openalex.org/W2040679107', 'https://openalex.org/W2043805597', 'https://openalex.org/W2048320638', 'https://openalex.org/W2054044810', 'https://openalex.org/W2061482690', 'https://openalex.org/W2063825413', 'https://openalex.org/W2064570326', 'https://openalex.org/W2092786021', 'https://openalex.org/W2093053369', 'https://openalex.org/W2095397920', 'https://openalex.org/W2098587560', 'https://openalex.org/W2103766655', 'https://openalex.org/W2109193129', 'https://openalex.org/W2126340181', 'https://openalex.org/W2129793678', 'https://openalex.org/W2135686166', 'https://openalex.org/W2144081223', 'https://openalex.org/W2148291080', 'https://openalex.org/W2171787690', 'https://openalex.org/W2326074019', 'https://openalex.org/W4231419782'], 'related_works': ['https://openalex.org/W2396686674', 'https://openalex.org/W2167875826', 'https://openalex.org/W2103511358', 'https://openalex.org/W2088663246', 'https://openalex.org/W2078842080', 'https://openalex.org/W2072779381', 'https://openalex.org/W2063089952', 'https://openalex.org/W2042930594', 'https://openalex.org/W200633664', 'https://openalex.org/W1785188379'], 'abstract_inverted_index': {'Non-nucleoside': [0], 'reverse': [1, 48, 87], 'transcriptase': [2, 49, 88], 'inhibitors': [3, 33, 64], '(NNRTIs)': [4], 'are': [5, 21], 'recommended': [6], 'components': [7], 'of': [8, 17, 30, 38, 42, 51, 93], 'preferred': [9], 'combination': [10], 'antiretroviral': [11], 'therapies': [12], 'used': [13], 'for': [14, 98], 'the': [15, 36, 47, 71, 85, 91, 96], 'treatment': [16], 'HIV.': [18], 'These': [19], 'regimens': [20], 'extremely': [22], 'effective': [23, 113], 'in': [24, 56, 65, 78, 84, 120], 'suppressing': [25], 'virus': [26], 'replication.': [27], 'Structure-based': [28], 'optimization': [29], 'diaryl': [31], 'ether': [32], 'led': [34], 'to': [35, 61, 82, 101, 110], 'discovery': [37], 'a': [39, 79], 'new': [40], 'series': [41], 'pyrazolo[3,4-c]pyridazine': [43], 'NNRTIs': [44, 107], 'that': [45, 83], 'bind': [46], 'enzyme': [50], 'human': [52], 'immunodeficiency': [53], 'virus-1': [54], '(HIV-RT)': [55], 'an': [57], 'expanded': [58], 'volume': [59], 'relative': [60], 'most': [62], 'other': [63], 'this': [66], 'class.The': [67], 'binding': [68], 'mode': [69], 'maintains': [70], 'beta13': [72], 'and': [73, 90, 116], 'beta14': [74], 'strands': [75], 'bearing': [76], 'Pro236': [77], 'position': [80], 'similar': [81], 'unliganded': [86], 'structure,': [89], 'distribution': [92], 'interactions': [94], 'creates': [95], 'opportunity': [97], 'substantial': [99], 'resilience': [100], 'single': [102], 'point': [103], 'mutations.': [104], 'Several': [105], 'pyrazolopyridazine': [106], 'were': [108], 'found': [109], 'be': [111], 'highly': [112], 'against': [114], 'wild-type': [115], 'NNRTI-resistant': [117], 'viral': [118], 'strains': [119], 'cell': [121], 'culture.': [122]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2003299861', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-04T02:22:11.208162', 'created_date': '2016-06-24'}