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638, 1041], 'study': [204, 743], 'determine': [207], 'whether': [208], 'showing': [215, 943], 'a': [220, 284, 292, 303, 378, 394, 547, 653, 751, 826, 899, 930, 965, 1019, 1084, 1181], 'nevirapine-based': [221, 285, 1020, 1099], 'regimen': [222], 'may': [223, 1168], 'allow': [224], 'them': [225], 'regain': [227], 'complete': [228, 995], 'viral': [229, 259, 352, 559, 602, 622, 680, 703, 718, 724, 879, 998, 1159], 'suppression.': [230], 'role': [232], 'effectiveness': [244], 'intervention': [247, 1042, 1066, 1183], 'also': [249, 970], 'analysed.': [250], 'For': [251], 'purpose,': [253], 'showed': [257, 929, 1014, 1136], 'load': [260, 353, 560, 681, 704, 719, 880], 'rebound': [261, 603, 623, 1160], 'over': [262, 356], 'HIV-RNA': [264, 318, 364, 565], '(confirmed': [266], 'two': [268, 308, 471, 758], 'separate': [269], 'specimens': [270], 'collected': [271], '2': [272], 'weeks': [273, 669, 695, 731, 779, 973, 1004], 'apart)': [274], 'after': [275, 338, 400, 776], 'being': [276], 'undetectable': [277, 678, 1139], 'least': [280], '3': [281, 927, 950, 1058], 'months': [282, 337, 553], 'triple': [286], 'combination': [287], '(nevirapine,': [288], '200': [289], 'mg': [290, 302], 'twice': [291], 'day)': [293, 304], 'were': [294, 329, 369, 391, 420, 478, 503, 745, 786, 807, 1131], 'selected.': [295], 'Nevirapine': [296, 366], 'substituted': [298], 'by': [299, 341, 651, 1046, 1105], '(600': [301], 'keeping': [305], 'same': [307, 407], 'nucleoside': [309], '(NRTI)': [313], 'as': [314, 412, 520, 750, 1125], 'backbone.': [315], 'level': [319], 'determined': [321, 370, 392], 'using': [322, 377, 405, 424, 505, 514], 'third-generation': [324], 'branched': [325], 'DNA': [326], 'assay.': [327], 'Measurements': [328], 'performed': [330, 441, 504], 'baseline,': [332], '3,': [333], '6': [334], '12': [336, 398, 832, 871], 'replacing': [339, 649], 'nevirapine': [340, 482, 596, 626, 650, 1140, 1150], 'efavirenz.': [342, 1186], 'A': [343, 567, 863], 'significant': [344, 654, 827, 865, 888, 931, 966], 'defined': [348], 'reduction': [354], '1': [357], 'log': [358, 722], 'reached': [360, 686], 'copies/ml.': [365, 566], 'before': [371], 'morning': [373], 'dose': [374, 403, 1204], 'intake': [375, 404], '(Ctrough)': [376], 'validated': [379], 'high-performance': [380, 408], 'liquid': [381, 409], 'chromatography': [382, 410], 'method': [383, 411], 'with': [384, 815, 916, 960, 1069], 'ultraviolet': [385], 'detection': [386], '[8].': [387], 'Efavirenz': [388], 'median': [395, 548, 556, 592], 'h': [399], 'night': [402], 'nevirapine.': [414, 1091], 'genetic': [418, 577], 'sequences': [419], 'obtained': [421], 'baseline': [423, 707], 'an': [425, 1206], 'automatic': [426], 'sequencer': [427], '(ABI': [428], '3000;': [429], 'Applied': [430], 'Biosystems,': [431], 'Foster': [432], 'city,': [433], 'CA,': [434], 'USA).': [435], 'Drug': [436], 'genotypic': [438], 'interpretation': [439], 'according': [442], 'latest': [445, 1189], 'International': [446, 496], 'AIDS': [447, 497], 'Society': [448, 498], 'USA': [449, 499], 'guidelines': [451], '(www.iasusa.org)': [452], 'expert': [454], 'advice.': [455], 'Resistance': [456, 480], 'considered': [460, 484, 524], 'either': [465, 515], 'K103N': [466], 'Y188L,': [468], 'more': [473, 587], 'present.': [479], 'any': [489, 800, 813], 'mutation': [492, 919], 'recorded': [493, 658, 712], 'list.': [500], 'Statistical': [501], 'analyses': [502], 'SPSS': [506], 'version': [507], '9.0': [508], '(SPSS': [509], 'Inc.,': [510], 'Chicago,': [511], 'IL,': [512], 'USA),': [513], 'parametric': [516], 'non-parametric': [518], 'tests': [519], 'needed.': [521], 'Significance': [522], 'P': [526, 859, 884, 905, 980, 987], 'values': [527], 'below': [528], '0.05.': [529], 'At': [530, 908], 'first': [534, 778, 1158], 'nevirapine,': [538], 'exposed': [542], 'drug': [545, 1147, 1175, 1192], '(range)': [549, 557], '7.4': [552], '(3–15).': [554], '4313': [562], '(72–45': [563], '148)': [564], 'total': [568], '29': [570], '35': [572], 'subjects': [573, 693], '(83%)': [574], 'whom': [576], 'material': [578], 'amplified': [581], 'sequenced': [583], 'harboured': [584], 'one': [585, 764], 'mutations.': [590, 1035, 1111], '(interquartile': [593], 'range;': [594], 'IQR)': [595], 'Ctrough': [597, 627], '3.6': [605, 852], 'μg/ml': [606, 631, 635, 853, 857, 928], '(2.4–4).': [607], 'Interestingly,': [608], 'lacking': [610], '(six': [614], 'out': [615, 739], '35)': [617], 'lower': [625], '[median': [628, 850], '(IQR)': [629, 851], '3.4': [630], '(2.05–4.05)': [632], 'versus': [633, 855, 978, 985], '0.03': [634], '(0–3.4)],': [636], 'although': [637, 757, 896], 'difference': [639], 'statistical': [643], 'significance': [644], '(P': [645], '=': [646, 860, 882, 885, 903, 906, 981, 988], '0.058).': [647], 'After': [648], 'efavirenz,': [652], '20': [660, 665], '(41.7%),': [661], '23': [662], '(48%)': [663], '(41.7%)': [666], '12,': [670, 696, 732, 910], '24': [671, 697, 733, 974], '48,': [673, 699, 895], 'respectively': [674], '(intent-to-treat': [675], 'analysis).': [676], 'An': [677], '(<': [682], 'copies/ml)': [684], '25,': [688], '39.6': [689], '41.7%': [691], 'respectively.': [700], 'reductions': [705], 'from': [706, 1170], 'each': [709], 'timepoint': [710, 814], 'are': [711], 'Table': [714, 820], '1.Table': [715], '1:': [716], 'Plasma': [717], 'changes': [720], '(Δ': [721], 'load)': [725], '48.It': [735], 'should': [736], 'pointed': [738], 'our': [742], 'there': [744], 'no': [746, 788], 'discontinuations': [747], 'therapy': [749], 'result': [752], 'efavirenz-related': [754], 'adverse': [755], 'effects,': [756], 'individuals': [759, 1130], 'complained': [760], 'dizziness': [762], 'vivid': [766], 'dreams': [767], 'plus': [768], 'insomnia.': [769], 'symptoms': [771], 'tended': [772], 'solve': [774], 'spontaneously': [775], 'therapy.': [781], 'When': [782], 'efavirenz-associated': [783, 835, 917], 'considered,': [787], 'timepoint.': [801], 'In': [802, 934, 1144, 1187], 'contrast,': [803, 935], 'responders': [811], 'respect': [816], 'non-responders': [818], '(see': [819], '1).': [821], 'Moreover,': [822], 'attained': [825], 'week': [831, 870, 894, 909], 'despite': [833], 'resistant': [836], 'significantly': [839], 'respond': [849], '(2.8–6.4)': [854], '2.7': [856], '(1.4–2.9);': [858], '0.027,': [861], 'respectively].': [862], 'positive': [864], 'correlation': [866, 889], 'Δlog': [877], '(r': [881, 902], '−0.4;': [883], '0.007).': [886], 'still': [891], 'present': [892], 'lesser': [900], 'extent': [901], '−0.41;': [904], '0.03).': [907], '75%': [911], 'greater': [925], 'response.': [933], 'it': [936], 'occurred': [937], 'only': [939], '22%': [940], 'μg/ml.': [951], 'threshold': [954], 'associated': [959, 1068], 'chance': [962], 'attaining': [964], 'confirmed': [971], '(79': [977], '40%;': [979], '0.03;': [982, 989], '76.4': [984], '41.6%;': [986], 'respectively).': [990], 'Our': [991], 'results': [992], 'demonstrate': [993], 'sustained': [997], 'suppression': [999], 'lasting': [1000], 'up': [1001, 1008], 'feasible': [1006], 'regimen.': [1021], 'benefit': [1023, 1169], 'taking': [1025], 'independent': [1028], 'initial': [1038], 'mainly': [1044], 'driven': [1045], 'concentrations.': [1049], 'attainment': [1051], 'adequate': [1053], '(>': [1057], 'μg/ml)': [1059], 'stages': [1063], 'chances': [1071], 'success.': [1074], 'Hypothetically,': [1075], 'overcome': [1081, 1209], 'relatively': [1085], 'large': [1086], 'proportion': [1087], 'almost': [1102], 'always': [1103], 'caused': [1104], 'selection': [1107], 'Only': [1112], '17%': [1113], 'lacked': [1116], 'failure,': [1123], 'expected': [1126], 'most': [1127], 'these': [1129], 'ot': [1133], 'compliant': [1134], 'low': [1137], 'trough': [1142], 'levels.': [1143], 'summary,': [1145], 'therapeutic': [1146, 1191], 'monitoring': [1148, 1193], 'help': [1162, 1199], 'identify': [1164], 'interventions': [1171], 'focused': [1172], 'improving': [1174], 'adherence': [1176], 'alternatively': [1178], 'attempt': [1180, 1207], 'rescue': [1182], 'based': [1184], 'situation,': [1190], 'optimize': [1201], 'resistance.': [1210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042930594', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T07:44:22.246085', 'created_date': '2016-06-24'}