Publication Information

{'id': 'https://openalex.org/W2002915433', 'doi': 'https://doi.org/10.1128/jvi.00106-11', 'title': 'HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism', 'display_name': 'HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism', 'publication_year': 2011, 'publication_date': '2011-02-24', 'ids': {'openalex': 'https://openalex.org/W2002915433', 'doi': 'https://doi.org/10.1128/jvi.00106-11', 'mag': '2002915433', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21345957', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3126252'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jvi.00106-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3126252?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081147347', 'display_name': 'Michael Roche', 'orcid': 'https://orcid.org/0000-0001-8819-0096'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Michael Roche', 'raw_affiliation_strings': ['Centers for Virology, Monash University, Victoria, Australia', 'Departments of Medicine, Monash University, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centers for Virology, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}, {'raw_affiliation_string': 'Departments of Medicine, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064287991', 'display_name': 'Martin R. Jakobsen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204337017', 'display_name': 'Aarhus University', 'ror': 'https://ror.org/01aj84f44', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I204337017']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU', 'DK'], 'is_corresponding': False, 'raw_author_name': 'Martin R. Jakobsen', 'raw_affiliation_strings': ['1Centers for Virology, Monash University, Victoria, Australia', '5Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark'], 'affiliations': [{'raw_affiliation_string': '5Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark', 'institution_ids': ['https://openalex.org/I204337017']}, {'raw_affiliation_string': '1Centers for Virology, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072751680', 'display_name': 'Jasminka Sterjovski', 'orcid': 'https://orcid.org/0000-0002-2471-3000'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jasminka Sterjovski', 'raw_affiliation_strings': ['1Centers for Virology, Monash University, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '1Centers for Virology, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091272416', 'display_name': 'Anne Ellett', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Anne Ellett', 'raw_affiliation_strings': ['1Centers for Virology, Monash University, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '1Centers for Virology, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072376088', 'display_name': 'Filippo Posta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Filippo Posta', 'raw_affiliation_strings': ['6Departments of Biomathematics, David Geffen School of Medicine, UCLA, Los Angeles, California'], 'affiliations': [{'raw_affiliation_string': '6Departments of Biomathematics, David Geffen School of Medicine, UCLA, Los Angeles, California', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070606892', 'display_name': 'Benhur Lee', 'orcid': 'https://orcid.org/0000-0003-0760-1709'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benhur Lee', 'raw_affiliation_strings': ['7Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California'], 'affiliations': [{'raw_affiliation_string': '7Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045042145', 'display_name': 'Becky Jubb', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180857899', 'display_name': 'Pfizer (United States)', 'ror': 'https://ror.org/01xdqrp08', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I180857899']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Becky Jubb', 'raw_affiliation_strings': ['8Pfizer Global Research and Development, Sandwich, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '8Pfizer Global Research and Development, Sandwich, United Kingdom', 'institution_ids': ['https://openalex.org/I180857899']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084731018', 'display_name': 'Mike Westby', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180857899', 'display_name': 'Pfizer (United States)', 'ror': 'https://ror.org/01xdqrp08', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I180857899']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mike Westby', 'raw_affiliation_strings': ['8Pfizer Global Research and Development, Sandwich, United Kingdom'], 'affiliations': [{'raw_affiliation_string': '8Pfizer Global Research and Development, Sandwich, United Kingdom', 'institution_ids': ['https://openalex.org/I180857899']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062645957', 'display_name': 'Sharon R. Lewin', 'orcid': 'https://orcid.org/0000-0002-0330-8241'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I2801993434', 'display_name': 'The Alfred Hospital', 'ror': 'https://ror.org/01wddqe20', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801993434', 'https://openalex.org/I4210163178']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Sharon R. Lewin', 'raw_affiliation_strings': ['3Departments of Medicine, Monash University, Victoria, Australia', '9Infectious Diseases Unit, Alfred Hospital, University of Melbourne, Victoria, Australia', 'Infectious Diseases Unit, Alfred Hospital, University of Melbourne, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '9Infectious Diseases Unit, Alfred Hospital, University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I165779595']}, {'raw_affiliation_string': 'Infectious Diseases Unit, Alfred Hospital, University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I2801993434']}, {'raw_affiliation_string': '3Departments of Medicine, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045316156', 'display_name': 'Paul A. Ramsland', 'orcid': 'https://orcid.org/0000-0002-2107-2738'}, 'institutions': [{'id': 'https://openalex.org/I145902186', 'display_name': 'Burnet Institute', 'ror': 'https://ror.org/05ktbsm52', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I145902186']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I4210163497', 'display_name': 'Austin Health', 'ror': 'https://ror.org/05dbj6g52', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210163497']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Paul A. Ramsland', 'raw_affiliation_strings': ['10Department of Surgery (Austin Health), University of Melbourne, Victoria, Australia', 'Department of Surgery (Austin Health), University of Melbourne, Victoria, Australia', 'Immunology, Burnet Institute, Monash University, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': 'Immunology, Burnet Institute, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I145902186', 'https://openalex.org/I56590836']}, {'raw_affiliation_string': '10Department of Surgery (Austin Health), University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I165779595']}, {'raw_affiliation_string': 'Department of Surgery (Austin Health), University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I4210163497', 'https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089216757', 'display_name': 'Melissa J. Churchill', 'orcid': 'https://orcid.org/0000-0001-5510-7954'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Melissa J. Churchill', 'raw_affiliation_strings': ['3Departments of Medicine, Monash University, Victoria, Australia', 'Departments of Medicine, Monash University, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '3Departments of Medicine, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}, {'raw_affiliation_string': 'Departments of Medicine, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091208578', 'display_name': 'Paul R. Gorry', 'orcid': 'https://orcid.org/0000-0001-5407-7124'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Paul R. Gorry', 'raw_affiliation_strings': ['11Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia', '3Departments of Medicine, Monash University, Victoria, Australia', 'Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia'], 'affiliations': [{'raw_affiliation_string': '3Departments of Medicine, Monash University, Victoria, Australia', 'institution_ids': ['https://openalex.org/I56590836']}, {'raw_affiliation_string': '11Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I165779595']}, {'raw_affiliation_string': 'Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia', 'institution_ids': ['https://openalex.org/I165779595']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.38, 'has_fulltext': False, 'cited_by_count': 77, 'citation_normalized_percentile': {'value': 0.906275, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '85', 'issue': '9', 'first_page': '4330', 'last_page': '4342'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9717, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/maraviroc', 'display_name': 'Maraviroc', 'score': 0.9422749}, {'id': 'https://openalex.org/keywords/ccr5-receptor-antagonist', 'display_name': 'CCR5 receptor antagonist', 'score': 0.8516135}, {'id': 'https://openalex.org/keywords/v3-loop', 'display_name': 'V3 loop', 'score': 0.73354506}, {'id': 'https://openalex.org/keywords/entry-inhibitor', 'display_name': 'Entry inhibitor', 'score': 0.42709193}], 'concepts': [{'id': 'https://openalex.org/C2778899366', 'wikidata': 'https://www.wikidata.org/wiki/Q421369', 'display_name': 'Maraviroc', 'level': 3, 'score': 0.9422749}, {'id': 'https://openalex.org/C37044404', 'wikidata': 'https://www.wikidata.org/wiki/Q5009692', 'display_name': 'CCR5 receptor antagonist', 'level': 5, 'score': 0.8516135}, {'id': 'https://openalex.org/C2779921545', 'wikidata': 'https://www.wikidata.org/wiki/Q12085358', 'display_name': 'V3 loop', 'level': 4, 'score': 0.73354506}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7024027}, {'id': 'https://openalex.org/C35693153', 'wikidata': 'https://www.wikidata.org/wiki/Q239762', 'display_name': 'Tropism', 'level': 3, 'score': 0.6810846}, {'id': 'https://openalex.org/C58475186', 'wikidata': 'https://www.wikidata.org/wiki/Q4118894', 'display_name': 'Viral entry', 'level': 4, 'score': 0.5710739}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49585947}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.48107195}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.47132948}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.46533006}, {'id': 'https://openalex.org/C97380033', 'wikidata': 'https://www.wikidata.org/wiki/Q994215', 'display_name': 'Viral envelope', 'level': 3, 'score': 0.4615839}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.45820358}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.4568686}, {'id': 'https://openalex.org/C2776997796', 'wikidata': 'https://www.wikidata.org/wiki/Q1345259', 'display_name': 'Entry inhibitor', 'level': 5, 'score': 0.42709193}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.42077416}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.41988558}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.33962655}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.26615158}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.2224927}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18442398}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.18105948}, {'id': 'https://openalex.org/C12823836', 'wikidata': 'https://www.wikidata.org/wiki/Q24720618', 'display_name': 'Chemokine receptor', 'level': 4, 'score': 0.16374716}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16178915}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003510', 'descriptor_name': 'Cyclohexanes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D019713', 'descriptor_name': 'Receptors, CCR5', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019380', 'descriptor_name': 'Anti-HIV Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003510', 'descriptor_name': 'Cyclohexanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015699', 'descriptor_name': 'HIV Envelope Protein gp120', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077592', 'descriptor_name': 'Maraviroc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019713', 'descriptor_name': 'Receptors, CCR5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056189', 'descriptor_name': 'Viral Tropism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jvi.00106-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3126252', 'pdf_url': 'https://europepmc.org/articles/pmc3126252?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126252', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21345957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3126252', 'pdf_url': 'https://europepmc.org/articles/pmc3126252?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1598451890', 'https://openalex.org/W1602599521', 'https://openalex.org/W1659719610', 'https://openalex.org/W1664573657', 'https://openalex.org/W1829913979', 'https://openalex.org/W1968127804', 'https://openalex.org/W1971620377', 'https://openalex.org/W1973581581', 'https://openalex.org/W1974089699', 'https://openalex.org/W1976127266', 'https://openalex.org/W1978377657', 'https://openalex.org/W1978795946', 'https://openalex.org/W1985440070', 'https://openalex.org/W1986191025', 'https://openalex.org/W1997979614', 'https://openalex.org/W2001768980', 'https://openalex.org/W2008708467', 'https://openalex.org/W2014733693', 'https://openalex.org/W2014990531', 'https://openalex.org/W2016309641', 'https://openalex.org/W2017070671', 'https://openalex.org/W2024011553', 'https://openalex.org/W2024588681', 'https://openalex.org/W2028661694', 'https://openalex.org/W2028968370', 'https://openalex.org/W2030565238', 'https://openalex.org/W2034799492', 'https://openalex.org/W2035503835', 'https://openalex.org/W2040186892', 'https://openalex.org/W2044004371', 'https://openalex.org/W2047059663', 'https://openalex.org/W2050977299', 'https://openalex.org/W2054839188', 'https://openalex.org/W2058252938', 'https://openalex.org/W2065283382', 'https://openalex.org/W2065753898', 'https://openalex.org/W2076091964', 'https://openalex.org/W2085464725', 'https://openalex.org/W2089677151', 'https://openalex.org/W2092664889', 'https://openalex.org/W2092913531', 'https://openalex.org/W2095164254', 'https://openalex.org/W2099308199', 'https://openalex.org/W2099666067', 'https://openalex.org/W2100805409', 'https://openalex.org/W2108561118', 'https://openalex.org/W2108982073', 'https://openalex.org/W2113012529', 'https://openalex.org/W2115212891', 'https://openalex.org/W2118208453', 'https://openalex.org/W2118937818', 'https://openalex.org/W2119480459', 'https://openalex.org/W2119951120', 'https://openalex.org/W2121117011', 'https://openalex.org/W2121593652', 'https://openalex.org/W2122224981', 'https://openalex.org/W2125291686', 'https://openalex.org/W2126255146', 'https://openalex.org/W2128618062', 'https://openalex.org/W2135781036', 'https://openalex.org/W2136000813', 'https://openalex.org/W2137903260', 'https://openalex.org/W2141489451', 'https://openalex.org/W2142035308', 'https://openalex.org/W2146426059', 'https://openalex.org/W2146478787', 'https://openalex.org/W2150001263', 'https://openalex.org/W2152971024', 'https://openalex.org/W2154142064', 'https://openalex.org/W2154626432', 'https://openalex.org/W2156838986', 'https://openalex.org/W2164585544', 'https://openalex.org/W2164681352', 'https://openalex.org/W2169054534', 'https://openalex.org/W2170119258', 'https://openalex.org/W2171136144', 'https://openalex.org/W4241759367'], 'related_works': ['https://openalex.org/W4387858887', 'https://openalex.org/W3009970267', 'https://openalex.org/W2147544546', 'https://openalex.org/W2125205795', 'https://openalex.org/W2088668371', 'https://openalex.org/W2067925490', 'https://openalex.org/W1976493037', 'https://openalex.org/W1970547415', 'https://openalex.org/W1879388876', 'https://openalex.org/W1122889353'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Maraviroc': [1], '(MVC)': [2], 'inhibits': [3], 'the': [4, 18, 21, 33, 42, 50, 57, 77, 84, 87, 113, 119, 122, 137, 147, 162, 167, 172, 176, 180, 185, 199, 231, 241, 248], 'entry': [5, 200], 'of': [6, 20, 41, 45, 60, 74, 86, 101, 121, 146, 175, 184, 194, 201, 250], 'human': [7], 'immunodeficiency': [8], 'virus': [9, 80], 'type': [10], '1': [11], '(HIV-1)': [12], 'by': [13, 226, 252], 'binding': [14], 'to': [15, 27, 99, 220], 'and': [16, 104, 132, 141, 151, 155, 179, 212, 255], 'modifying': [17], 'conformation': [19, 44], 'CCR5': [22, 114, 131, 138, 149, 232, 251], 'extracellular': [23], 'loops': [24], '(ECLs).': [25], 'Resistance': [26], 'MVC': [28, 53, 225], 'results': [29, 236], 'from': [30, 62, 76], 'alterations': [31], 'in': [32, 63, 110, 118, 166, 210, 216], 'HIV-1': [34, 67, 202, 223], 'gp120': [35, 61, 75, 168], 'envelope': [36], 'glycoproteins': [37], '(Env)': [38], 'enabling': [39], 'recognition': [40], 'drug-bound': [43], 'CCR5.': [46], 'To': [47], 'better': [48], 'understand': [49], 'mechanisms': [51], 'underlying': [52], 'resistance,': [54], 'we': [55], 'characterized': [56], 'virus-cell': [58, 260], 'interactions': [59, 239, 261], 'vitro': [64], '-generated': [65], 'MVC-resistant': [66], '(MVC-Res': [68], 'Env),': [69], 'comparing': [70], 'them': [71], 'with': [72, 96, 130, 240], 'those': [73], 'sensitive': [78], 'parental': [79], '(MVC-Sens': [81], 'Env).': [82], 'In': [83, 218], 'absence': [85], 'drug,': [88, 123], 'MVC-Res': [89, 124, 253], 'Env': [90, 125, 254], 'maintains': [91], 'a': [92, 106], 'highly': [93], 'efficient': [94], 'interaction': [95], 'CCR5,': [97], 'similar': [98], 'that': [100, 161, 222, 244, 262], 'MVC-Sens': [102], 'Env,': [103], 'displays': [105], 'relatively': [107], 'modest': [108], 'increase': [109], 'dependence': [111], 'on': [112, 136, 142, 230], 'N': [115, 139, 188, 233], 'terminus.': [116], 'However,': [117], 'presence': [120], 'interacts': [126], 'much': [127], 'less': [128], 'efficiently': [129], 'becomes': [133], 'critically': [134], 'dependent': [135, 229], 'terminus': [140, 189], 'positively': [143], 'charged': [144], 'elements': [145], 'drug-modified': [148, 242], 'ECL1': [150], 'ECL2': [152], 'regions': [153], '(His88': [154], 'His181,': [156], 'respectively).': [157], 'Structural': [158], 'analysis': [159], 'suggests': [160], 'Val323': [163], 'resistance': [164], 'mutation': [165], 'V3': [169, 177, 186], 'loop': [170, 178], 'alters': [171], 'secondary': [173], 'structure': [174], 'buried': [181], 'surface': [182], 'area': [183], 'loop–CCR5': [187], 'interface.': [190], 'This': [191], 'altered': [192], 'mechanism': [193], 'gp120-CCR5': [195], 'engagement': [196], 'dramatically': [197], 'attenuates': [198], 'into': [203, 259], 'monocyte-derived': [204], 'macrophages': [205], '(MDM),': [206], 'cell-cell': [207], 'fusion': [208], 'activity': [209], 'MDM,': [211], 'viral': [213], 'replication': [214], 'capacity': [215], 'MDM.': [217], 'addition': [219], 'confirming': [221], 'escapes': [224], 'becoming': [227], 'heavily': [228], 'terminus,': [234], 'our': [235], 'reveal': [237], 'novel': [238], 'ECLs': [243], 'are': [245], 'critical': [246], 'for': [247], 'utilization': [249], 'provide': [256], 'additional': [257], 'insights': [258], 'modulate': [263], 'macrophage': [264], 'tropism.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2002915433', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-24T15:39:40.548330', 'created_date': '2016-06-24'}