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964, 980, 982, 984, 1038, 1040, 1042, 1044, 1127, 1256, 1355, 1406, 1408, 1412, 1444, 1446, 1450, 1498, 1500, 1540, 1544, 1674, 1725, 1729, 1855], 'Nagata,': [215], 'Furuta': [217], 'Yokokura.': [220], '1990.': [221, 258, 298, 583], 'Metabolism': [222], 'pharmacokinetics': [224, 725, 1424, 1519, 1564, 1821], 'camptothecin': [227, 262, 469, 542, 1652, 1864], 'analogue': [228, 263], 'CPT-11': [229, 412, 529, 627, 764, 839, 1056, 1280, 1381, 1426, 1467, 1566, 1787, 1815, 1823], 'mouse.': [232], 'Res.': [234, 279, 738, 1018, 1390, 1478, 1532, 1574, 1625, 1757, 1795, 1882, 1914], '50:': [235, 280], '1715–1720.': [236], '3': [237, 1622, 1657], 'Kanzawa,': [238, 1078, 1724, 1764, 1886], 'F.,': [239, 1887], 'Y.': [240, 320, 395, 399, 446, 519, 564, 566, 570, 574, 576, 655, 704, 748, 786, 883, 929, 968, 972, 1024, 1032, 1083, 1089, 1119, 1181, 1199, 1248, 1252, 1268, 1297, 1369, 1396, 1440, 1494, 1552, 1767, 1771, 1773, 1804, 1843], 'Sugimoto,': [241], 'K.': [242, 244, 248, 287, 293, 322, 393, 448, 458, 517, 556, 581, 611, 617, 623, 657, 661, 706, 712, 752, 758, 788, 878, 925, 966, 1028, 1073, 1085, 1117, 1123, 1141, 1185, 1197, 1242, 1258, 1311, 1363, 1400, 1442, 1455, 1488, 1490, 1548, 1596, 1697, 1721, 1731, 1765, 1806, 1851, 1858, 1888], 'Minato,': [243], 'Kasahara,': [245], 'Bungo,': [247], 'Nakagawa,': [249, 662, 713, 791, 831, 1124], 'Fujiwara,': [251, 870, 1772], 'L.': [252, 1581, 1593, 1690], 'F.': [253, 974, 1034, 1077, 1091, 1414, 1496, 1723, 1763], 'Liu': [254], 'N.': [256, 316, 324, 403, 450, 659, 700, 710, 756, 802, 921, 988, 991, 1049, 1075, 1139, 1177, 1250, 1271, 1299, 1372, 1417, 1509, 1555, 1736, 1776, 1809, 1890, 1893], 'Saijo.': [257, 992, 1050, 1272, 1373, 1418, 1510, 1556, 1737, 1777, 1810, 1894], 'Establishment': [259], '(CPT-11)-resistant': [264], 'cell': [265, 270, 433, 478, 859, 907, 1014, 1222, 1286, 1338, 1752, 1791, 1910], 'line': [266], 'human': [268, 1158, 1750, 1872], 'non-small': [269, 432, 1013, 1221, 1285, 1337], 'lung': [271, 354, 434, 479, 688, 772, 823, 860, 908, 950, 1015, 1165, 1223, 1287, 1339, 1527, 1753, 1789], 'cancer:': [272, 1340], 'Characterization': [273], 'mechanism': [275], 'resistance.': [277], '5919–5924.': [281], '4': [282], 'Taguchi,': [283, 409, 524], 'A.': [285, 389, 513, 560, 702, 790, 978, 1081, 1131, 1133, 1183, 1301, 1404, 1410, 1486, 1639, 1675, 1802, 1853], 'Wakui,': [286, 514], 'Hasegawa,': [288, 394], 'Niitani,': [290, 388], 'Furue,': [292], 'Ohta': [294], 'Hattori.': [297], 'Phase': [299, 334, 535, 675, 808, 845, 894, 994, 1052, 1147, 1274, 1321, 1420, 1603, 1645, 1705], 'I': [300, 335, 676, 809, 995, 1053, 1148, 1275, 1421, 1604, 1646, 1706, 1744, 1782], 'clinical': [301, 996, 1103], 'study': [302, 336, 421, 537, 588, 679, 810, 847, 940, 1054, 1151, 1212, 1276, 1323, 1422, 1607], 'CPT-11.': [304, 1474, 1712], 'Jpn.': [305, 735, 953, 1387, 1475, 1529, 1571, 1879], 'J.': [306, 356, 436, 481, 548, 603, 644, 691, 736, 774, 825, 986, 1046, 1065, 1167, 1388, 1431, 1476, 1502, 1530, 1572, 1634, 1662, 1671, 1677, 1679, 1713, 1832, 1880], '17:': [309], '115–120.': [310], '5': [311], 'Negoro,': [312, 402, 455, 709, 751, 801], 'S.,': [313, 697, 920], 'Fukuoka,': [315, 363, 385, 445, 652, 699, 745, 783, 834, 875, 924, 1114], 'Masuda,': [317, 404, 442, 649, 701, 742, 780, 1111], 'Takada,': [319, 747, 1122], 'Kusunoki,': [321, 447, 656, 705, 749, 787, 1120], 'Matsui,': [323, 449, 658, 707, 753, 789, 1118], 'Takifuji,': [325, 451, 660, 711, 757, 1140], 'S.': [326, 401, 405, 452, 454, 578, 619, 653, 669, 708, 750, 754, 761, 784, 800, 876, 1115, 1144, 1187, 1189, 1191, 1193, 1262, 1307, 1357, 1506, 1538, 1585, 1684, 1691, 1849], 'Kudoh,': [327, 453, 654, 696, 755, 785, 919, 1116, 1312], 'Niitani': [329, 836], 'Taguchi.': [332], '1991.': [333], 'weekly': [338, 1711], 'intravenous': [339], 'infusion': [340, 1620], 'treatment': [350, 472, 598], 'advanced': [352, 687, 770, 821, 856, 1012, 1164, 1829], 'non-small-cell': [353, 771, 822], 'cancer.': [355, 435, 480, 547, 689, 773, 824, 861, 951, 1016, 1166, 1288, 1528, 1831], 'Natl.': [357, 1432, 1833], 'Inst.': [359, 1434, 1835], '83:': [360], '1164–1168.': [361], '6': [362], 'Masuda.': [367], '1994.': [368, 633, 807, 893, 993, 1096, 1146, 1511, 1602, 1811], 'studies': [370, 1649], 'irinotecan': [372, 640, 681, 727, 812, 849, 898, 942, 999, 1153, 1214, 1325, 1654], 'alone': [373], 'combination': [376, 683, 731, 766, 1005], 'cisplatin.': [378, 734], '34:': [382, 1108], 'S105–S111.': [383], '7': [384], 'M.,': [386, 1241, 1720], 'Suzuki,': [390, 1190], 'Motomiya,': [392], 'Nishiwaki,': [396, 1176], 'Kuriyama,': [398], 'Ariyoshi,': [400, 567, 884, 930], 'Nakajima': [406], 'Lung': [413, 840, 889], 'Study': [415, 532, 628, 842, 891, 896], 'Group.': [416, 533, 843, 892], '1992.': [417, 463, 763, 1419, 1778], 'A': [418, 465, 591, 937, 1209, 1341, 1375, 1558, 1861], 'phase': [419, 586, 938, 1210], 'II': [420, 536, 587, 846, 895, 939, 1211], 'previously': [430], 'untreated': [431], 'Clin.': [437, 482, 549, 604, 775, 826, 865, 914, 1066, 1168, 1235, 1292, 1350, 1663, 1714], 'Oncol.': [438, 483, 550, 605, 776, 827, 866, 915, 1067, 1169, 1236, 1293, 1351, 1664, 1715], '10:': [439, 484, 777], '16–20.': [440], '8': [441], 'Nishioka,': [457], 'Nakagawa': [459, 759], 'Takada.': [462, 673, 720, 806], 'CPT-11:': [464, 590, 1512], 'refractory': [474, 1062], 'or': [475], 'relapsed': [476], 'small': [477, 858, 906, 1751], '1225–1229.': [485], '9': [486], 'Society': [487], 'Japanese': [489, 1226, 1342], 'Pharmacopoeia.': [490], '1995.': [491, 721, 936, 1208, 1374, 1457, 1557, 1644, 1860, 1895], 'Summary': [492], 'Basis': [493], 'Approval': [495], '(SBA)': [496], 'No.': [497], '1.': [498], 'hydrochloride': [500, 641], '(Campto': [501], 'injection,': [502], 'injection).,': [504], 'Yakuji': [505], 'Nippo,': [506], 'Ltd.': [507], '10': [508], 'Shimada,': [509, 1805], 'Y.,': [510, 871, 1354, 1395, 1439, 1537, 1801], 'Yoshino,': [512], 'I.': [515, 1195, 1550, 1694], 'Nakao,': [516], 'Futatsuki,': [518], 'Sakata,': [520], 'Kambe,': [522], 'Ogawa': [526], 'The': [528, 626, 838, 886], 'Gastrointestinal': [530], '1993.': [534, 674, 844, 1051, 1704], 'derivative,': [543, 1865], 'metastatic': [545, 1220, 1284], 'colorectal': [546, 1830], '11:': [551, 1068, 1716], '909–913.': [552], '11': [553], 'Ohno,': [554, 614], 'R.,': [555], 'Okada,': [557, 618], 'Masaoka,': [559, 616], 'Kuramoto,': [561], 'Arima,': [563], 'Yoshida,': [565, 1441], 'Ichimaru,': [569], 'Sakai,': [571], 'Oguro,': [573], 'Ito,': [575], 'Morishima,': [577], 'Yokomaku': [579], 'Ota.': [582], 'An': [584], 'early': [585], 'leukemia': [600], 'lymphoma.': [602], '8:': [606], '1907–1912.': [607], '12': [608], 'Tsuda,': [609], 'H.,': [610], 'Takatsuki,': [612], 'R.': [613, 1266, 1599, 1680, 1688], 'Shirakawa,': [620], 'Ohashi,': [622], 'Ota': [624], 'Group': [629, 1229, 1345], 'on': [630], 'Hematological': [631], 'Malignancy.': [632], 'Treatment': [634], 'adult': [636], 'T-cell': [637], 'leukemia-lymphoma': [638], '(CPT-11).': [642], 'Br.': [643, 690], '70:': [646], '771–774.': [647], '13': [648], 'Tamanoi,': [664, 795], 'Nitta,': [666, 797, 1138], 'Hirashima,': [668, 715, 793, 1126], 'Negoro': [670], 'pharmacologic': [678, 1150, 1648], 'cisplatin': [685, 768, 814, 852, 901, 945, 1003, 1328, 1741], '68:': [693], '777–782.': [694], '14': [695], 'Yoshikawa,': [703, 1132], 'Yana': [717], 'Relationship': [722], 'between': [723, 1460, 1740], 'diarrhea': [729], 'during': [730], 'chemotherapy': [732], '86:': [739, 1391, 1479, 1575, 1836, 1883], '406–413.': [740], '15': [741], 'Kishimoto.': [762], '1775–1780.': [778], '16': [779], 'Yana,': [799, 1130], 'Takifuji': [803], 'granulocyte': [816, 1159], 'colony-stimulating': [817, 1160], 'factor': [818, 1161], 'support': [819, 1162], '12:': [828, 867, 1170], '90–96.': [829], '17': [830], 'K.,': [832, 1174, 1580], '(CPT-11)': [850, 899, 1215, 1326, 1615], 'patients': [854, 904, 947, 1060, 1471, 1525, 1827], 'non': [857], 'Proc.': [862, 911, 952, 1232, 1289, 1347], 'Am.': [863, 912, 1233, 1290, 1348], 'Soc.': [864, 913, 954, 1234, 1291, 1349], '335.': [868, 917], 'Yamakido,': [873], 'Kudo,': [877], 'Furuse,': [879, 926], 'Ikegami': [881], 'West': [887], 'Japan': [888], '(CDDP)': [902], 'cancer': [909, 1224, 1660, 1754, 1790], '(SCLC)': [910], '13:': [916, 1665], '19': [918], 'Kurihara,': [922], 'Ikegami,': [928], 'Takada': [932], 'Takeda.': [935], 'combined': [943], 'small-cell': [949], 'Chest': [955], 'Diseases': [956], '33:': [957], '272.': [958], '20': [959], 'Shinkai,': [960, 1027, 1080, 1245, 1366, 1399, 1493, 1503], 'Arioka,': [963, 1041, 1499, 1730], 'Kunikane,': [965, 1039, 1407], 'Eguchi,': [967, 1029, 1086, 1243, 1364, 1401, 1491], 'Sasaki,': [969, 1025, 1084, 1353, 1397, 1438, 1536, 1800], 'Tamura,': [971, 1031, 1088, 1247, 1314, 1368, 1403, 1485], 'Ohe,': [973, 1033, 1090, 1249, 1394, 1495], 'Oshita,': [975, 1035, 1497], 'Nishio,': [977, 1037, 1074, 1722, 1766, 1889], 'Karato,': [979, 1022, 1082, 1411, 1487], 'Okamoto,': [981, 1409], 'Nakashima,': [983, 1045, 1501], 'Ohmatsu,': [985, 1043, 1257, 1413], 'Shiraishi,': [987], 'Nomura': [989], 'trial': [997, 1709], '(CPT-11),': [1000], '7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin,': [1001], 'fixed': [1007], 'dose': [1008], 'vindesine': [1010], '54:': [1019, 1626], '2636–2642.': [1020], '21': [1021], 'A.,': [1023, 1296], 'Shiraishi': [1047], 'etoposide': [1058, 1155, 1217], 'solid': [1063], 'tumors.': [1064], '2030–2035.': [1069], '22': [1070], 'Saijo,': [1071, 1178, 1300], 'Kubota,': [1076, 1259, 1761], 'Oshita': [1092], 'Nishio.': [1095], '7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy': [1097], 'camptothecin:': [1098], 'Mechanism': [1099], 'resistance': [1101], 'trials.': [1104], 'S112–S117.': [1109], '23': [1110], 'Tsukada,': [1128], 'Kubo,': [1134], 'E.': [1135, 1579, 1587, 1841], 'Matsuura,': [1136], 'Terakawa': [1142], 'Negoro.': [1145], 'recombinant': [1157], '1833–1841.': [1171], '24': [1172], 'Goto,': [1173], 'Nakabayashi,': [1180, 1304], 'Kawakami,': [1182], 'Fujita,': [1184], 'Tobise,': [1186], 'Abe,': [1188], 'Tsuchiya,': [1192], 'Takahashi,': [1194], 'Hayashi,': [1196], 'Noda,': [1198, 1302], 'Kurita,': [1200, 1298], 'Matsuda,': [1202], 'Tamura': [1204], 'Shimoyama.': [1207], '(VP-16)': [1218], '(NSCLC):': [1225], 'Oncology': [1228, 1344], '(JCOG)': [1230], 'Trial.': [1231, 1346], '14:': [1237], '362.': [1238], '25': [1239], 'Ando,': [1240], 'Yamamoto,': [1251, 1482], 'Kurata,': [1253], 'Kasai,': [1255], 'Sekine,': [1261, 1551], 'Hojo,': [1263], 'Matsumoto,': [1265], 'Kakinuma,': [1267], 'Nishiwaki': [1269], '1996.': [1273, 1320, 1738], 'sequentially': [1278], 'administered': [1279, 1616, 1655], 'VP-16': [1282], '26': [1294], 'Yokoyama,': [1295], 'Tukamoto,': [1306], 'Yoneda,': [1308], 'Masuya,': [1310], 'Shimokata': [1316], 'Matsuda.': [1319], 'I-II': [1322], 'plus': [1329], 'concurrent': [1330], 'thoracic': [1331], 'radiation': [1332], 'therapy': [1333], 'stage': [1335], 'III': [1336], '27': [1352], 'Hakusui,': [1356, 1445], 'Mizuno,': [1358, 1539], 'Morita,': [1360], 'Miya,': [1362], 'Ohe': [1370], 'pharmacokinetic': [1376, 1514, 1708], 'pharmacodynamic': [1378], 'analysis': [1379], 'its': [1383, 1568], 'active': [1384], 'metabolite': [1385, 1569], 'SN-38.': [1386, 1570], '101–110.': [1392], '28': [1393], 'Kojima,': [1405], 'Kanzawa': [1415], '5-day': [1428], 'continuous': [1429], 'infusion.': [1430], '84:': [1435], '972–974.': [1436], '29': [1437], 'Sudoh,': [1443], 'Fujii,': [1447, 1541], 'Ohtsu,': [1449, 1543, 1803], 'Wakita,': [1451, 1545], 'Igarashi': [1453], 'Ito.': [1456], 'Pharmacological': [1458], 'correlation': [1459], 'total': [1461], 'drug': [1462], 'concentration': [1463], 'lactones': [1465], 'SN-38': [1469, 1825], 'treated': [1472], '111–116.': [1480], '30': [1481], 'Uenaka,': [1489], 'Fukuda,': [1505, 1719], 'Higuchi': [1507], 'Population': [1513], 'model': [1515, 1561], 'estimation': [1517], 'using': [1520], 'Bayesian': [1522], 'method': [1523], '85:': [1533], '972–977.': [1534], '31': [1535], 'Igarashi,': [1547], 'Itoh,': [1549], 'Miyata': [1553], 'limited': [1559], 'sampling': [1560], 'estimating': [1563], '117–123.': [1576], '32': [1577], 'Rowinsky,': [1578], 'B.': [1582, 1589], 'Grochow,': [1583], 'D.': [1584, 1642, 1700, 1701], 'Ettinger,': [1586], 'Sartorius,': [1588], 'G.': [1590, 1631, 1632, 1672, 1685, 1687, 1693], 'Lubejko,': [1591], 'Chen,': [1594], 'Rock': [1597, 1698], 'C.': [1600], 'Donehower.': [1601], 'pharmacological': [1606], 'novel': [1610], 'topoisomerase': [1611, 1743, 1781], 'inhibitor': [1613], '7-ethyl-10-[4-(1-piperidino)-1-piperidino-Icarbonyloxycamptothecin': [1614], 'as': [1617], 'ninety-minute': [1619], 'every': [1621, 1656], 'weeks.': [1623], '427–436.': [1627], '33': [1628], 'Abigerges,': [1629], 'D.,': [1630], 'Chabot,': [1633], 'P.': [1635, 1637], 'Armand,': [1636], 'Herait,': [1638], 'Gouyette': [1640], 'Gandia.': [1643], 'analog': [1653], 'weeks': [1658], 'patients.': [1661], '210–221.': [1666], '34': [1667], 'Rothenberg,': [1668], 'L.,': [1670], 'Kuhn,': [1673], 'Burris,': [1676], 'Nelson,': [1678], 'Eckardt,': [1681], 'Tristan-Morales,': [1683], 'Hilsenbeck,': [1686], 'Weiss,': [1689], 'Smith,': [1692], 'Rodriguez,': [1695], 'Van': [1702], 'Hoff': [1703], '2194–2204.': [1717], '35': [1718], 'Ogasawara,': [1726], 'Ishida,': [1728], 'Bajanowski,': [1732], 'Oka': [1734], 'Synergism': [1739], 'inhibitors,': [1745], 'NB506': [1746], 'SN-38,': [1748], 'cells.': [1755], '56:': [1758], '789–793.': [1759], '36': [1760], 'Takeda,': [1768], 'Ohmori,': [1770], 'Terashima': [1774], 'Detection': [1779], 'gene': [1783], 'point': [1784], 'mutation': [1785], 'resistant': [1788], 'line.': [1792], 'Biochem.': [1793], 'Biophys.': [1794], 'Commun.': [1796], '188:': [1797], '571–577.': [1798], '37': [1799], 'Ono': [1807], 'Simultaneous': [1812], 'administration': [1813], 'fluorouracil:': [1817], 'Alteration': [1818], '1096–1098.': [1837], '38': [1838], 'Mitsui,': [1839], 'I.,': [1840], 'Kumazawa,': [1842], 'Hirota,': [1844], 'Aonuma,': [1846], 'Sugimori,': [1848], 'Ohkushi,': [1850], 'Uoto,': [1852], 'Ejima,': [1854], 'Terasawa': [1856], 'Sato.': [1859], 'water-soluble': [1863], 'DX-8951f,': [1866], 'exhibits': [1867], 'potent': [1868], 'antitumor': [1869], 'activity': [1870], 'against': [1871], 'tumors': [1873], 'vitro': [1875], 'vivo.': [1878], '776–782.': [1884], '39': [1885], 'Kubota': [1891], 'Antitumor': [1896], 'activities': [1897], 'indolecarbozole': [1901], 'substance,': [1902], 'NB-506.': [1903], 'establishment': [1905], 'NB-506-resistant': [1909], 'lines,': [1911], 'SBC-3/NB.': [1912], '55:': [1915], '2806–2813.': [1916], 'Citing': [1917], 'Literature': [1918], 'Volume803,': [1919], 'Issue1The': [1920], 'Camptothecins:': [1921], 'From': [1922], 'Discovery': [1923], 'PatientDecember': [1926], '1996Pages': [1927], 'ReferencesRelatedInformation': [1929]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1999080392', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-11T12:27:54.032881', 'created_date': '2016-06-24'}