Title: [Effects of cu2+ on biosynthesis of camptothecin in cell cultures of Camptotheca acuminata].
Abstract:Camptothecin is a strong anti-tumor compound isolated from Camptotheca acuminata. One of the most important way for the production of Camptothecin is by cell cultures of Camptotheca acuminata. The eff...Camptothecin is a strong anti-tumor compound isolated from Camptotheca acuminata. One of the most important way for the production of Camptothecin is by cell cultures of Camptotheca acuminata. The effect of Cu~(2+) on camptothecin accumulation in Camptotheca acuminata cell line was described in this paper. The results showed that the optimum CuCl-2 concentration in B5 medium was 0.008mg/mL, which increased camptothecin production for 30 times compare to the control while has no inhibitive effects on cell growth, at the same time, the peroxidase activity was increased and the anthocyanidin accumulation was inhibited. The promotive effects of Cu~(2+) on camptothecin accumulation in light was higher than that in dark.Read More
Publication Year: 2006
Publication Date: 2006-07-01
Language: en
Type: article
Indexed In: ['pubmed']
Access and Citation
Cited By Count: 5
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