Title: Metabolism of [14C]pyridoxol in the pregnant rat
Abstract: 1. [14C]Pyridoxol was administered to pregnant rats and the distribution of isotope between pyridoxol, pyridoxal, pyridoxamine, pyridoxol 5′-phosphate, pyridoxal 5′-phosphate, pyridoaxamine 5′-phosphate, 4-pyridoxic acid, 4-pyridoxic acid lactone, and 4-pyridoxic acid 5′-phosphate was determined at different times after injection in liver, kidneys, spleen, brain, uterus, placentae, foetuses, blood and urine. 2. Pyridoxol was rapidly phosphorylated to pyridoxal phosphate via pyridoxol phosphate in tissues. 3. Pyridoxamine phosphate and pyridoxal tissue levels gradually rose as a result of transamination and hydrolysis of pyridoxal phosphate. 4. Large amounts of pyridoxal phosphate were oxidised to pyridoxic acid phosphate which was retained by tissues until hydrolysed to pyridoxic acid. 5. Only small amounts of pyridoxal were oxidised to pyridoxic acid. 6. Pyridoxal phosphate was the form of the vitamin that was actively transported to the foetus in both humans and rats. 7. New chromatographic methods are described for the separation of vitamin B6-metabolites.
Publication Year: 1971
Publication Date: 1971-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 46
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