Publication Information

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'inhibiting': [823, 977, 997], 'may': [826, 918, 971, 1034], 'useful': [828, 973], 'reasons.': [831], 'resistance': [837], 'Smo,': [840], 'components': [848, 894, 905], 'downstream': [851], '(e.g.,': [854, 875], 'mutation': [855], 'negative': [858], 'Sufu': [861], 'amplifications': [863], 'Glis),': [865], 'direct': [867], 'induction': [868], 'transforming': [873], 'Ews-Fli': [876], 'Ewing': [878], 'sarcoma': [879], 'mutant': [881], 'KRas': [882], 'cancer).': [885], 'To': [886], 'end,': [888], 'novel': [889, 940, 1103], 'compounds': [890, 976], 'signal': [892, 1006, 1076], 'transduction': [893, 1007], 'beyond': [895], 'identified.': [899], 'Since': [900, 954], 'not': [907], 'repress': [919], 'neutralizing': [925], 'monoclonal': [926], 'antibody': [927], '5E1': [928], 'anti-tumor': [931, 1099], 'disease': [935, 1061], 'models.': [936], 'addition,': [938], 'agent': [941], 'robotnikinin': [942], 'prevent': [947], '(10).': [953], 'cumulates': [957], 'transcriptional': [959, 1456], 'Glis,': [962], 'molecules': [964], 'modulating': [965], '(GANT-58': [968], 'GANT-61)': [970], '(11).': [974], 'Furthermore,': [975], 'altering': [981], 'cellular': [986, 1023, 1085], 'localization': [987], '(HPI-1,': [992], 'HPI-2,': [993], 'HPI-3,': [994], 'arsenic)': [995], 'formation': [999, 1142], 'primary': [1001], 'cilia': [1002], '(HPI-4)': [1008], '(12,': [1012], '13).': [1013], 'Finally,': [1014], 'possible': [1017], 'interaction': [1020, 1079], 'pathways,': [1024, 1086], 'PI3K/AKT,': [1027], 'MAPK,': [1028], 'TGF-β,': [1029], 'Liver': [1031], '×': [1032], 'receptors': [1033], 'wide': [1051], 'variety': [1052], 'malignancies': [1055, 1095], 'roles': [1059], 'initiation,': [1062], 'relapse,': [1063], 'progression.': [1065], 'improved': [1067], 'understanding': [1068], 'basic': [1071], 'mechanisms': [1072], 'govern': [1074], 'transduction,': [1077], 'precise': [1089], 'specific': [1094], 'should': [1096], 'improve': [1097], 'approaches.': [1104], 'References:': [1105], '1.': [1106], 'Ruiz': [1107], 'i': [1108], 'Altaba': [1109], 'A,': [1110, 1244, 1378], 'Mas': [1111, 1249], 'C,': [1112, 1168, 1250, 1319], 'Stecca': [1113], 'B.': [1114], 'code:': [1117], 'information': [1119], 'nexus': [1120], 'regulating': [1121], 'fate,': [1123], 'stemness': [1124], 'cancer.': [1126, 1204], 'Trends': [1127], 'Cell': [1128], 'Biol.': [1129, 1372], '2007;17:438–47.': [1130], '2.': [1131], 'Pasca': [1132], 'di': [1133], 'Magliano': [1134], 'M,': [1135, 1246, 1248, 1376], 'Hebrok': [1136], 'M.': [1137], 'signalling': [1139, 1263], 'maintenance.': [1144], 'Nat': [1145, 1191, 1370], 'Rev': [1146], 'Cancer.': [1147], '2003;3:903–11.': [1148], '3.': [1149], 'Merchant': [1150], 'AA,': [1151], 'Matsui': [1152], 'W.': [1153], 'Targeting': [1154], '—': [1156], 'pathway.': [1161], 'Clin': [1162], 'Can': [1163], 'Res.': [1164, 1206], '2010;16:3130–40.': [1165], '4.': [1166], 'Dierks': [1167], 'Grbic': [1169], 'J,': [1170, 1220, 1284, 1321, 1434, 1436], 'Zirlik': [1171], 'K,': [1172, 1350, 1412], 'Beigi': [1173], 'R,': [1174, 1323, 1325], 'Englund': [1175], 'NP,': [1176], 'Guo': [1177], 'G-R,': [1178], 'et': [1179, 1221, 1253, 1295, 1326, 1355, 1413], 'al.': [1180, 1222, 1254, 1296, 1327, 1356, 1414], 'Essential': [1181], 'stromally': [1184], 'induced': [1185], 'hedgehog': [1186], 'B-cell': [1189], 'malignancies.': [1190], 'Med.': [1192, 1280, 1340], '2007;13:944–51.': [1193], '5.': [1194], 'Theunissen': [1195], 'J-W,': [1196], 'de': [1197], 'Sauvage': [1198], 'FJ.': [1199], 'Cancer': [1205, 1482, 1494], '2009;69:6007–10.': [1207], '6.': [1208], 'Peacock': [1209], 'CD,': [1210], 'Wang': [1211, 1289, 1351], 'Q,': [1212], 'Gesell': [1213], 'GS,': [1214], 'Corcoran-Schwartz': [1215], 'IM,': [1216], 'Jones': [1217], 'E,': [1218], 'Kim': [1219, 1433], 'maintains': [1225], 'compartment': [1230], 'myeloma.': [1233], 'Proc': [1234, 1394, 1424, 1458], 'Natl': [1235, 1395, 1425, 1459], 'Acad': [1236, 1396, 1426, 1460], 'Sci': [1237, 1397, 1427, 1461], 'USA.': [1238, 1398], '2007;104:4048–53.': [1239], '7.': [1240], 'Varnat': [1241], 'F,': [1242], 'Duquet': [1243], 'Malerba': [1245], 'Zbinden': [1247], 'Gervaz': [1251], 'P,': [1252, 1317], 'Human': [1255], 'harbour': [1260], 'HEDGEHOG-GLI': [1262], 'essential': [1266], 'growth,': [1269], 'recurrence,': [1270], 'metastasis': [1271], 'expansion.': [1277], 'Embo': [1278], 'Mol': [1279, 1493], '2009;1.': [1281], '8.': [1282], 'Taipale': [1283], 'Chen': [1285], 'JK,': [1286], 'Cooper': [1287], 'MK,': [1288], 'B,': [1290], 'Mann': [1291], 'RK,': [1292], 'Milenkovic': [1293], 'L,': [1294], 'Effects': [1297], 'oncogenic': [1299], 'reversed': [1307], 'Nature.': [1310], '2000;406:1005–9.': [1311], '9.': [1312], 'Von': [1313], 'Hoff': [1314], 'D,': [1315, 1438], 'Lorusso': [1316], 'Rudin': [1318], 'Reddy': [1320], 'Yauch': [1322], 'Tibes': [1324], 'Inhibition': [1328, 1383], 'basal-cell': [1335], 'carcinoma.': [1336], 'N': [1337], 'Engl': [1338], 'J': [1339], '2009.': [1341], '10.': [1342], 'Stanton': [1343], 'BZ,': [1344], 'Peng': [1345], 'LF,': [1346], 'Maloof': [1347], 'N,': [1348], 'Nakai': [1349], 'X,': [1352], 'Duffner': [1353], 'JL,': [1354], 'molecule': [1359], 'blocks': [1364], 'its': [1365], 'Chem': [1371], '2009;5:154–6.': [1373], '11.': [1374], 'Lauth': [1375], 'Bergström': [1377], 'Shimokawa': [1379], 'T,': [1380], 'Toftgård': [1381], 'R.': [1382], 'GLI-mediated': [1385], 'small-molecule': [1392], 'antagonists.': [1393], '2007;104:8455–60.': [1399], '12.': [1400], 'Hyman': [1401], 'JM,': [1402], 'Firestone': [1403], 'AJ,': [1404], 'Heine': [1405], 'VM,': [1406], 'Zhao': [1407], 'Y,': [1408], 'Ocasio': [1409], 'CA,': [1410], 'Han': [1411], 'Small-molecule': [1415], 'inhibitors': [1416], 'reveal': [1417], 'strategies': [1419], 'blockade.': [1423], 'U': [1428, 1462], 'S': [1429, 1463], 'A.': [1430, 1464], '2009;106:14132–7.': [1431], '13.': [1432], 'Lee': [1435], 'Gardner': [1437], 'Beachy': [1439], 'P.': [1440], 'Arsenic': [1441], 'antagonizes': [1442], 'preventing': [1447], 'ciliary': [1448], 'accumulation': [1449], 'reducing': [1451], 'stability': [1452], 'effector.': [1457], '2010;107:13432.': [1465], 'Citation': [1466], 'Format:': [1467], '{Authors}.': [1468], '{Abstract': [1469], 'title}': [1470], '[abstract].': [1471], 'In:': [1472], 'Proceedings': [1473], 'AACR-NCI-EORTC': [1476], 'International': [1477], 'Conference:': [1478], 'Molecular': [1479], 'Targets': [1480], 'Therapeutics;': [1483], '2011': [1484], 'Nov': [1485], '12-16;': [1486], 'San': [1487], 'Francisco,': [1488], 'CA.': [1489], 'Philadelphia': [1490], '(PA):': [1491], 'AACR;': [1492], 'Ther': [1495], '2011;10(11': [1496], 'Suppl):Abstract': [1497], 'nr': [1498], 'CN06-04.': [1499]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995093795', 'counts_by_year': [], 'updated_date': '2024-12-08T13:15:35.681583', 'created_date': '2016-06-24'}