Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2083909752', 'doi': 'https://doi.org/10.3892/ijo.2013.2010', 'title': 'Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma', 'display_name': 'Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma', 'publication_year': 2013, 'publication_date': '2013-07-08', 'ids': {'openalex': 'https://openalex.org/W2083909752', 'doi': 'https://doi.org/10.3892/ijo.2013.2010', 'mag': '2083909752', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23835807', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3787891'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2013.2010', 'pdf_url': 'https://www.spandidos-publications.com/ijo/43/3/695/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.spandidos-publications.com/ijo/43/3/695/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000505028', 'display_name': 'S Kanda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shiori Kanda', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017545087', 'display_name': 'Takeshi Mitsuyasu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Mitsuyasu', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102119403', 'display_name': 'Yu Nakao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yu Nakao', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100533899', 'display_name': 'Shintaro Kawano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shintaro Kawano', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101700625', 'display_name': 'Yuichi Goto', 'orcid': 'https://orcid.org/0000-0003-1248-7664'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuichi Goto', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066376144', 'display_name': 'Ryota Matsubara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryota Matsubara', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085142320', 'display_name': 'Seiji Nakamura', 'orcid': 'https://orcid.org/0000-0002-6373-8817'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Seiji Nakamura', 'raw_affiliation_strings': ['Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.675, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.764077, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '43', 'issue': '3', 'first_page': '695', 'last_page': '702'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11787', 'display_name': 'Classification and Management of Odontogenic Tumors', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/3504', 'display_name': 'Oral Surgery'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11669', 'display_name': 'Endoscopic Skull Base Surgery Techniques', 'score': 0.9684, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclopamine', 'display_name': 'Cyclopamine', 'score': 0.9685942}, {'id': 'https://openalex.org/keywords/gli1', 'display_name': 'GLI1', 'score': 0.9265058}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.81117696}, {'id': 'https://openalex.org/keywords/gli2', 'display_name': 'GLI2', 'score': 0.76410747}, {'id': 'https://openalex.org/keywords/ameloblastoma', 'display_name': 'Ameloblastoma', 'score': 0.589208}, {'id': 'https://openalex.org/keywords/hedgehog-signaling', 'display_name': 'Hedgehog Signaling', 'score': 0.573349}, {'id': 'https://openalex.org/keywords/gli3', 'display_name': 'GLI3', 'score': 0.559271}, {'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.55277807}], 'concepts': [{'id': 'https://openalex.org/C2777605378', 'wikidata': 'https://www.wikidata.org/wiki/Q3271319', 'display_name': 'Cyclopamine', 'level': 4, 'score': 0.9685942}, {'id': 'https://openalex.org/C2779933373', 'wikidata': 'https://www.wikidata.org/wiki/Q14886430', 'display_name': 'GLI1', 'level': 4, 'score': 0.9265058}, {'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.81628054}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.81117696}, {'id': 'https://openalex.org/C120407494', 'wikidata': 'https://www.wikidata.org/wiki/Q14886491', 'display_name': 'GLI2', 'level': 4, 'score': 0.76410747}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67159486}, {'id': 'https://openalex.org/C2775876115', 'wikidata': 'https://www.wikidata.org/wiki/Q461857', 'display_name': 'Ameloblastoma', 'level': 3, 'score': 0.632034}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.6147053}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.5617232}, {'id': 'https://openalex.org/C97182474', 'wikidata': 'https://www.wikidata.org/wiki/Q14886904', 'display_name': 'GLI3', 'level': 5, 'score': 0.559271}, {'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.55277807}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5509493}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.48787045}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43811834}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34407532}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.21832481}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.21745485}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.092244655}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.06431782}, {'id': 'https://openalex.org/C122246415', 'wikidata': 'https://www.wikidata.org/wiki/Q350956', 'display_name': 'Maxilla', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000564', 'descriptor_name': 'Ameloblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007573', 'descriptor_name': 'Jaw Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000564', 'descriptor_name': 'Ameloblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000564', 'descriptor_name': 'Ameloblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007573', 'descriptor_name': 'Jaw Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007573', 'descriptor_name': 'Jaw Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2013.2010', 'pdf_url': 'https://www.spandidos-publications.com/ijo/43/3/695/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3787891', 'pdf_url': 'https://europepmc.org/articles/pmc3787891?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23835807', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2013.2010', 'pdf_url': 'https://www.spandidos-publications.com/ijo/43/3/695/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1641336178', 'https://openalex.org/W1676048097', 'https://openalex.org/W1698663755', 'https://openalex.org/W1966435498', 'https://openalex.org/W1978762849', 'https://openalex.org/W1980591242', 'https://openalex.org/W1981343224', 'https://openalex.org/W1992865216', 'https://openalex.org/W1994620081', 'https://openalex.org/W2000572318', 'https://openalex.org/W2002355858', 'https://openalex.org/W2015187834', 'https://openalex.org/W2018790511', 'https://openalex.org/W2030718399', 'https://openalex.org/W2030931871', 'https://openalex.org/W2038585541', 'https://openalex.org/W2039205449', 'https://openalex.org/W2039640335', 'https://openalex.org/W2044616474', 'https://openalex.org/W2055296003', 'https://openalex.org/W2055792519', 'https://openalex.org/W2067238392', 'https://openalex.org/W2078087720', 'https://openalex.org/W2086152184', 'https://openalex.org/W2089893410', 'https://openalex.org/W2094475901', 'https://openalex.org/W2095439711', 'https://openalex.org/W2096148741', 'https://openalex.org/W2108707301', 'https://openalex.org/W2124176030', 'https://openalex.org/W2127001212', 'https://openalex.org/W2140619393', 'https://openalex.org/W2163341423', 'https://openalex.org/W2163838718', 'https://openalex.org/W2164310262'], 'related_works': ['https://openalex.org/W2104639069', 'https://openalex.org/W2100564455', 'https://openalex.org/W2089766172', 'https://openalex.org/W2083909752', 'https://openalex.org/W2074863882', 'https://openalex.org/W2044348636', 'https://openalex.org/W2021390830', 'https://openalex.org/W1974035062', 'https://openalex.org/W1973523868', 'https://openalex.org/W1969050050'], 'abstract_inverted_index': {'Sonic': [0], 'hedgehog': [1], '(SHH)': [2], 'signaling': [3, 18, 31, 169], 'pathway': [4, 19, 40, 170], 'is': [5, 171], 'crucial': [6], 'to': [7, 84], 'growth': [8], 'and': [9, 33, 60, 62, 82, 104, 110, 149, 159, 176], 'patterning': [10], 'during': [11], 'organogenesis.': [12], 'Aberrant': [13], 'activation': [14], 'of': [15, 29, 37, 44, 51, 76, 88, 93, 99, 115, 124, 141, 147, 184], 'the': [16, 27, 35, 38, 42, 46, 52, 66, 74, 86, 91, 107, 122, 139, 167, 182], 'SHH': [17, 30, 39, 77, 79, 89, 125, 142, 168], 'can': [20], 'result': [21], 'in': [22, 41, 106, 121, 138, 174, 181], 'tumor': [23, 50], 'formation.': [24], 'We': [25, 54, 71, 96], 'examined': [26], 'expression': [28, 98, 157, 161], 'molecules': [32], 'investigated': [34], 'involvement': [36], 'proliferation': [43, 92, 114, 183], 'ameloblastoma,': [45], 'most': [47], 'common': [48], 'benign': [49], 'jaws.': [53], 'used': [55, 73], 'immunohistochemistry': [56], 'on': [57, 65, 90], 'ameloblastoma': [58, 67, 108, 175, 185], 'specimens': [59, 109], 'immunocytochemistry': [61], 'reverse': [63], 'transcription-PCR': [64], 'cell': [68], 'line': [69], 'AM-1.': [70], 'also': [72], 'inhibitors': [75], 'signaling,': [78], 'neutralizing': [80, 126, 143], 'antibody': [81, 127], 'cyclopamine,': [83], 'assess': [85], 'effects': [87], 'AM-1': [94, 111], 'cells.': [95, 112], 'detected': [97], 'SHH,': [100], 'patched,': [101], 'GLI1,': [102], 'GLI2': [103, 150], 'GLI3': [105], 'The': [113], 'these': [116], 'cells': [117, 186], 'was': [118, 131, 151, 154], 'significantly': [119], 'inhibited': [120], 'presence': [123, 140], 'or': [128], 'cyclopamine;': [129], 'this': [130], 'confirmed': [132], 'by': [133], 'BrdU': [134], 'incorporation': [135], 'assays.': [136], 'Furthermore,': [137], 'antibody,': [144], 'nuclear': [145], 'translocation': [146], 'GLI1': [148], 'abolished,': [152], 'apoptosis': [153], 'induced,': [155], 'BCL-2': [156], 'decreased': [158], 'BAX': [160], 'increased.': [162], 'Our': [163], 'results': [164], 'suggest': [165], 'that': [166], 'constitutively': [172], 'active': [173], 'plays': [177], 'an': [178], 'anti-apoptotic': [179], 'role': [180], 'through': [187], 'autocrine': [188], 'loop': [189], 'stimulation.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083909752', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-08-13T14:59:59.585314', 'created_date': '2016-06-24'}