Plasma-Cell Myeloma

Name: Work Video:
Duration: 3 min 30 s
Description: A patient with plasma-cell myeloma was followed for thirty years. The main features of the case were: late onset of multiple bone lesions, paraproteinemia, responsiveness to radiotherapy, absence of Bence Jones proteinuria, and failure of diffuse plasma-cell myeloma to develop. Large doses of radiation do not eradicate these lesions.
Arsen M. Pankovich; Melvin L. Griem
{'id': 'https://openalex.org/W1994452505', 'doi': 'https://doi.org/10.1148/104.3.521', 'title': 'Plasma-Cell Myeloma', 'display_name': 'Plasma-Cell Myeloma', 'publication_year': 1972, 'publication_date': '1972-09-01', 'ids': {'openalex': 'https://openalex.org/W1994452505', 'doi': 'https://doi.org/10.1148/104.3.521', 'mag': '1994452505', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5051467'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1148/104.3.521', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50280174', 'display_name': 'Radiology', 'issn_l': '0033-8419', 'issn': ['0033-8419', '1527-1315'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315931', 'host_organization_name': 'Radiological Society of North America', 'host_organization_lineage': ['https://openalex.org/P4310315931'], 'host_organization_lineage_names': ['Radiological Society of North America'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041562445', 'display_name': 'Arsen M. Pankovich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arsen M. Pankovich', 'raw_affiliation_strings': ['Department of Orthopedics The University of Chicago Chicago, Ill. 60637'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedics The University of Chicago Chicago, Ill. 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067170980', 'display_name': 'Melvin L. Griem', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Melvin L. Griem', 'raw_affiliation_strings': ['Department of Orthopedics The University of Chicago Chicago, Ill. 60637'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopedics The University of Chicago Chicago, Ill. 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.766, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.749352, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '104', 'issue': '3', 'first_page': '521', 'last_page': '522'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11221', 'display_name': 'Bone health and treatments', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/paraproteinemia', 'display_name': 'Paraproteinemias', 'score': 0.9588299}, {'id': 'https://openalex.org/keywords/bence-jones-protein', 'display_name': 'Bence Jones protein', 'score': 0.9004612}, {'id': 'https://openalex.org/keywords/plasma-cell-myeloma', 'display_name': 'Plasma Cell Myeloma', 'score': 0.8072481}, {'id': 'https://openalex.org/keywords/plasma-cell-neoplasm', 'display_name': 'Plasma cell neoplasm', 'score': 0.48944154}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9598596}, {'id': 'https://openalex.org/C2776148967', 'wikidata': 'https://www.wikidata.org/wiki/Q4301818', 'display_name': 'Paraproteinemia', 'level': 3, 'score': 0.9588299}, {'id': 'https://openalex.org/C52697466', 'wikidata': 'https://www.wikidata.org/wiki/Q424176', 'display_name': 'Bence Jones protein', 'level': 4, 'score': 0.9004612}, {'id': 'https://openalex.org/C2908937092', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Plasma Cell Myeloma', 'level': 3, 'score': 0.8072481}, {'id': 'https://openalex.org/C2776396001', 'wikidata': 'https://www.wikidata.org/wiki/Q250694', 'display_name': 'Plasma cell', 'level': 3, 'score': 0.806816}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.77749693}, {'id': 'https://openalex.org/C2779561371', 'wikidata': 'https://www.wikidata.org/wiki/Q570197', 'display_name': 'Proteinuria', 'level': 3, 'score': 0.49919868}, {'id': 'https://openalex.org/C2909638373', 'wikidata': 'https://www.wikidata.org/wiki/Q1706485', 'display_name': 'Plasma cell neoplasm', 'level': 4, 'score': 0.48944154}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.4765592}, {'id': 'https://openalex.org/C2778964538', 'wikidata': 'https://www.wikidata.org/wiki/Q2090167', 'display_name': 'Plasmacytoma', 'level': 3, 'score': 0.44039193}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38776731}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2918515}, {'id': 'https://openalex.org/C36394416', 'wikidata': 'https://www.wikidata.org/wiki/Q949267', 'display_name': 'Immunoglobulin light chain', 'level': 3, 'score': 0.19773886}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.16766286}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1596691}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.085074514}], 'mesh': [{'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D001536', 'descriptor_name': 'Bence Jones Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001536', 'descriptor_name': 'Bence Jones Protein', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D001536', 'descriptor_name': 'Bence Jones Protein', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001797', 'descriptor_name': 'Blood Protein Electrophoresis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D010386', 'descriptor_name': 'Pelvic Neoplasms', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D010386', 'descriptor_name': 'Pelvic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011859', 'descriptor_name': 'Radiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013125', 'descriptor_name': 'Spinal Neoplasms', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D013125', 'descriptor_name': 'Spinal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1148/104.3.521', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S50280174', 'display_name': 'Radiology', 'issn_l': '0033-8419', 'issn': ['0033-8419', '1527-1315'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315931', 'host_organization_name': 'Radiological Society of North America', 'host_organization_lineage': ['https://openalex.org/P4310315931'], 'host_organization_lineage_names': ['Radiological Society of North America'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5051467', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4200034747', 'https://openalex.org/W3205250783', 'https://openalex.org/W3036797428', 'https://openalex.org/W2409857713', 'https://openalex.org/W2402812168', 'https://openalex.org/W2319515760', 'https://openalex.org/W2170602136', 'https://openalex.org/W2017254108', 'https://openalex.org/W1998881647', 'https://openalex.org/W1994452505'], 'abstract_inverted_index': {'A': [0], 'patient': [1], 'with': [2], 'plasma-cell': [3, 36], 'myeloma': [4, 37], 'was': [5], 'followed': [6], 'for': [7], 'thirty': [8], 'years.': [9], 'The': [10], 'main': [11], 'features': [12], 'of': [13, 19, 28, 34, 42], 'the': [14], 'case': [15], 'were:': [16], 'late': [17], 'onset': [18], 'multiple': [20], 'bone': [21], 'lesions,': [22], 'paraproteinemia,': [23], 'responsiveness': [24], 'to': [25, 38], 'radiotherapy,': [26], 'absence': [27], 'Bence': [29], 'Jones': [30], 'proteinuria,': [31], 'and': [32], 'failure': [33], 'diffuse': [35], 'develop.': [39], 'Large': [40], 'doses': [41], 'radiation': [43], 'do': [44], 'not': [45], 'eradicate': [46], 'these': [47], 'lesions.': [48]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994452505', 'counts_by_year': [], 'updated_date': '2024-12-09T05:28:02.359096', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
